DRUG STUDY

GENERIC NAME: Amantadine Hcl

Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble
in alcohol
and in chloroform.
Amantadine hydrochloride has pharmacological actions as both an anti-Parkinson and an antiviral drug.
Brand name:
Drug Classification:

DOSAGE, ROUTE, SIDE EFFECTS and

FREQUENCY (prescribed and INDICATION MECHANISM OF ADVERSE REACTIONS
recommended) ACTION (by system)
 Amantadine Hydrochloride The mechanism by which CNS Effects: Patients with a
Dosage Form: capsule, liquid filled Capsules, USP are indicated Amantadine exerts its antiviral history of epilepsy or other
for the prophylaxis and activity is not clearly understood.
CREATININE CLEARANCE It appears to mainly prevent the
"seizures" should be
treatment of signs and
(mL/min/1.73 m2) release of infectious viral nucleic observed closely for possible
symptoms of infection
Amantadine Hydrochloride acid into the host cell by increased seizure activity.
caused by various strains of interfering with the function of
Capsules Patients receiving
influenza A virus. the transmembrane domain of
DOSAGE Amantadine Hydrochloride the viral M2 protein. In certain Amantadine hydrochloride
30 to 50 200 mg 1st day Capsules, USP are also cases, Amantadine is also known capsules who note central
and 100 mg each day indicated in the treatment of to prevent virus assembly during nervous system effects or
thereafter parkinsonism and drug- virus replication. It does not blurring of vision should be
induced extrapyramidal appear to interfere with the
15 to 29 200 mg 1st day cautioned against driving or
immunogenicity of inactivated
followed by 100 mg on reactions. working in situations where
alternate days Following vaccination during influenza A virus vaccine. alertness and adequate
an influenza A outbreak,
<15 200 mg every 7 days motor coordination are
Amantadine Hydrochloride
important.
Capsules, USP prophylaxis
Melanoma
should be considered for the
2- to 4-week time period
required to develop an Cardiovascular --cardiac
antibody response. arrest, arrhythmias including
malignant arrhythmias,
hypotension, and
tachycardia;
Respiratory -acute respiratory
failure, pulmonary edema,
and tachypnea;
Gastrointestinal -dysphagia;
Hematologic -leukocytosis;
agranulocytosis
Special Senses -keratitis and
mydriasis;
Skin and Appendages -
pruritus and diaphoresis;
Miscellaneous -neuroleptic
malignant syndrome (see
WARNINGS), allergic
reactions including
anaphylactic reactions,
edema and fever.
Laboratory Test -elevated:
CPK, BUN, serum creatinine,
alkaline phosphatase, LDH,
bilirubin, GGT, SGOT, and
SGPT.

NURSING RESPONSIBILITIES
CONTRAINDICATION/S (at least 10)
 Contraindications
Amantadine Hydrochloride
Capsules are contraindicated in
patients with known
hypersensitivity to Amantadine
hydrochloride or to any of the
other ingredients in Amantadine
Hydrochloride Capsules.
Drug-Induced Extrapyramidal
Reactions: Amantadine
Hydrochloride Capsules, USP are
indicated in the treatment of
drug-induced extrapyramidal
reactions. Although
anticholinergic-type side effects
have been noted with
Amantadine Hydrochloride
Capsules, USP when used in
patients with drug-induced
extrapyramidal reactions, there
is a lower incidence of these
side effects than that observed
with the anticholinergic
antiparkinson drugs.
Deaths: Deaths have been
reported from overdose with
Amantadine hydrochloride. The
lowest reported acute lethal
dose was 1 gram. Acute toxicity
may be attributable to the
anticholinergic effects of
Amantadine. Drug overdose has
resulted in cardiac, respiratory,
renal or central nervous system
toxicity. Cardiac dysfunction
includes arrhythmia, tachycardia
and hypertension (see
OVERDOSAGE ).

Patient’s Name / Room No.