®

TM
DR. STUART TITUS
Co-Founder and President of
Medical Marijuana, Inc.
STUART TITUS
Co-Founder and President of Medical Marijuana, Inc.

• Stuart began his association with our family of companies in 2008,

playing a pivotal role in raising capital for Medical Marijuana Inc. 

(OTC: MJNA), among several other duties.
• Stuart practiced as a British physiotherapist for fifteen years, running
clinics specializing in pain management and injury rehabilitation.
• Stuart has unique first-hand experience with hemp oil products as
nutritional supplements, having found great relief from Lyme disease
symptoms after beginning a regimen of therapeutic high-
concentration CBD hemp products.
Intro to Medical Benefits of CBD/Cannabis
Brief History of Cannabis

• Cannabis has been part of human evolution

since the beginning of recorded history.

• In ancient Chinese times, cannabis was used as a

medicine, including its oils, tinctures and 

cannabis-based preparations.

• Today’s presentation concerns the recent

developments in clinical research regarding the
re-establishment of “Cannabis as a Medicine”.
1930’s and Cannabis’ Demise

• Up until the late 1930’s cannabis based medications: oils, tinctures and preparations were
routinely used by American doctors and physicians worldwide. The following pictures
depict some of the many types of cannabis-based medicinal products that were available.
Hemp vs. Marijuana - Part I (Understanding the Differences)

Hemp Marijuana
• Tall and lengthy (can grow 10-20 feet high) • Short and bushy (grows about waist high)
• High concentration of CBD (non-psychoactive) • High concentration of THC (psychoactive)
• Around the world, it is grown mostly for fiber, • Grown for psychoactive effect
and used in textiles • No industrial application
• Hemp seeds are the seed from the plant known
as Cannabis sativa
Hemp vs. Marijuana - Part II
Hemp
• Hemp food products are fully legal in the USA
• Hemp food products are regularly found in US
health food stores
• Hemp seed, hemp oil, hemp protein powder
(Understanding the Differences)
Marijuana
• Remains illegal at federal level
• 30 US states, plus Washington D.C. legalize
for medical purposes
• 17 US states approve CBD forms of marijuana
for epilepsy children
• 4 US states + D.C. have legalized for recreational usage
What Are Cannabinoids?

• Cannabinoids are special compounds found in the Cannabis plant family, and there are
at least 80, possibly up to 100, known cannabinoids.

• There are nearly 400 other chemical compounds in cannabis that are common to all plants 

— like chlorophyll, terpenoids, flavonoids and plant waxes.

• Cannabinoids and cannabinoid like compounds are found in a handful of other plants
such as Echinacea, flax, common tea, kava and hops.

• One of these cannabinoid like compounds, called Beta-caryophyllene, is a terpenoid that

appears to behave like a cannabinoid in the body. It can be found in dozens of plants
consumed every day (black pepper, hops, rosemary, oregano, basil, lavender, cinnamon and
more). Beta-caryophyllene exhibits antioxidant properties, partly by acting on the
endocannabinoid system.
Cannabinoids Extracts
What is the Endocannabinoid System?

• Our bodies have an entire regulatory system called the endocannabinoid system
(ECS), or the endogenous cannabinoid system. In fact, this endocannabinoid
system is the largest, self regulating system within our bodies. The ECS uses
cannabinoids to transmit certain signals and regulate homeostasis within us - it
serves to balance our mood, appetite, sleep and hormone production.

• Plant based cannabinoids have analogues in the human body, meaning that our
bodies produce cannabinoids too. Our cells have receptor sites for cannabinoids
(CB-1 and CB-2, described below), and this helps regulate our immune system.

• The major endogenous cannabinoids are Anandamide (AEA) and 2-AG

• Please see Dr. David Allen's review of the endocannabinoid system here.
What is the Endocannabinoid System?
What is the Endocannabinoid System?

• The CB1 neurotransmitter receptor site in the brain has more

receptor sites than ALL OF THE OTHER neurotransmitter
sites… COMBINED!

• Thus, our bodies are designed to accept plant based

cannabinoids – in fact, these are the foods of our “Biological
Adaptation”.
Additional Cannabinoid Receptor Sites

• G Protein Coupled Receptor Sites Controls the function of 800 human genes
(4% of the entire human genomic sequence)
• Vanilloid Pain Receptor Sites
• Internal Organs, including fat cells of the Liver Controls metabolism
• Also Lungs, Kidneys
• Glands Pituitary, Hypothalamus, Thymus, Thyroid, Adrenal
• The ECS is present from Day 16 of Gestation and regulates the development of the
entire Central Nervous System
CB1 Receptors in the Brain
 To supplement the LARGEST self-regulatory system within
the human body, take plant based phyto-cannabinoids daily!
Endocannabinoid System Facts

Did You Know:

• The "Runner's High" is a phenomena created by production and

release of the endogenous cannabinoid, Anandamide, as well as
Endorphins - both are "feel good" neurotransmitters. Only Anandamide
crosses the blood-brain barrier, thus responsible for the "Runner's
High" effect.

• That a mother's breast milk contains significant quantities of

cannabinoids
Clinical Endocannabinoid Deficiency Syndrome

• First postulated by a Dr. Ethan Russo, a famous cannabis researcher.

• If one is deficient in cannabinoids, one may develop numerous “treatment

resistant conditions", such as migraine headache, fibromyalgia, and chronic
fatigue syndrome

• Subsequent research has confirmed that underlying endocannabinoid

deficiencies indeed play a role in migraine, fibromyalgia, irritable bowel syndrome
and a growing list of other medical conditions. Clinical experience is bearing this
out.


• Further research and, especially, clinical trials will further demonstrate the
usefulness of medical cannabis/ medical hemp including non-psychoactive CBD .
As legal barriers fall and scientific bias fades this will become more apparent.

• Recently the US Drug Enforcement Administration (DEA) has relaxed barriers to

CBD research - this as of Dec 23, 2015
The Entourage Effect

• All 500 chemical compounds native in

cannabis act synergistically to produce a
far greater effect than that of single or
double active ingredient extraction.

• Thus, natural, botanical cannabinoids

and natural, botanical products may have
significantly greater effects for patients
than synthetic, pharmaceutical versions.

• An excellent explanation by Dr. Sanjay

Gupta may be viewed here.
U.S. Government Patent #6,630,507

• Regarding the therapeutic usage of cannabinoids,

titled: Cannabinoids as Antioxidants and
Neuroprotectants

• Patent awarded in 2003 to a team headed by Nobel

Prize Winning Laureate, Dr. Julius Axelrod

• Cannabinoids are useful in the treatment of a wide

range of oxidative-related conditions such as ischemic,
age related, inflammatory and autoimmune diseases.

• In the treatment of neurodegenerative diseases such

as Alzheimer's, Parkinson's, Chronic Traumatic
Encephalopathy (CTE), etc.

• Non-psychoactive cannabinoids, such as cannabidiol

(CBD) are particularly advantageous as they avoid
toxicity related issues of psychoactive cannabinoids.
Traumatic Brain Injury

• Research from UCLA Medical Center in Torrance, California involved 446

young adults who suffered auto accidents and related traumatic brain
injury.

• Interestingly, the regular cannabis users among this group of young

adults were 80% more likely to survive, presumably because their brain
cells had that extra layer of neuroprotection that medical cannabis and
CBD can provide.

• Research was published in The American Surgeon

Traumatic Brain Injury

We feel that every young "at-risk-for

head-injury" athlete should be taking
non-psychoactive plant based
cannabinoids -as they provide
neuroprotection - in a sense, a second
football helmet, that is always with you -
to guard against any unforeseen athletic
or other head / brain related injury.
 Increase in the Occurrence of Neurological Diseases

• We have seen a recent news release from Mayo Clinic researchers (June 21 2016) who had been studying
neurological trends for the past 30 years and reported their findings in JAMA Neurology.

• This report cited the significant increase in Parkinson’s disease and “parkinsonism” particularly in men over
the age of 70 years. This is the first study to suggest such a trend, according to researchers.

The numbers:

For every 10 calendar years of life:

• Men of all ages have a 17% higher risk of developing “parkinsonism”
and
• Men of all ages have a 24% higher risk of developing Parkinson’s disease

• Dr. Rodolfo Savica, MD, PhD, the study lead author mentions that “we have evidence to suggest that there
has been a genuine increase in the risk of Parkinson’s disease.”
A Company of Firsts ®

• Medical Marijuana Inc. was the FIRST publicly traded company in the US to engage with the
legal cannabis space.

• We created the CBD hemp oil category along with the FIRST pipeline from Europe, and
introduced the FIRST natural botanical hemp-based CBD products into US markets.

• We were the FIRST to bring legal cannabis product into Brazil, Puerto Rico (where we now
hold 12 product registrations), and now Mexico.
• First in Direct Selling

• We take our place in history very seriously because the path we blazed has
revolutionized the way people think about both hemp and cannabis.

• In short: the legal hemp-based CBD industry in the United States did not exist until
Medical Marijuana Inc. and our subsidiaries developed it.
World Anti-Doping Standards

• Pure CBD is the first cannabis based

product that would qualify under World
Anti-Doping Standards in Direct Selling.

• These World Anti-Doping Standards

show that 207 compounds are banned.

• Our Pure CBD does not contain or metabolize

into ANY of these 207 compounds.
Post-Chemotherapy Dr. Abrams

• Pain, depression, nausea, vomiting, loss of

appetite, sleep

• Can Rx 6 different meds all with varying

•

side effects and potential harmful drug

interactions

• Or just Rx Cannabis

• CBD may have a significant role here

CBD Research

• Epilepsy

• Metabolic Syndrome

• Broken bones
1

• Osteoporosis

• Parkinson’s

• Alzheimer's

• Anti-Cancer

• Neuro-Protection / Traumatic Brain Injury

Stanford University Study Points to Endocannabinoid Deficiency

as Cause of Alzheimer’s

• A new study led by investigators at the

Stanford University School of Medicine has
implicated the blocking of endocannabinoids 

— signaling substances that are the brain’s
internal versions of the psychoactive
chemicals in marijuana and hashish — in the
early pathology of Alzheimer’s disease.
 “Great spirits have
always encountered
violent opposition from
mediocre minds.”

- Albert Einstein
The Remake of Hemp Vap
Although preferred by the younger generation for "entertainment" we have
seen great anecdotal feedback from the Kannaway Brand Ambassadors.

It is extremely exciting to show this new product now with:

* 100 mgs CBD in the new cartridge
* Refill cartridges available
* More CBD, More "puff for your buck"
* Potential Health & Wellness Benefits too..!
Everyone Breathes
An often overlooked characteristic of all living humans is that we all breathe and
can potentially benefit from this unique "delivery method".

A medical researcher at Temple University mentions that "all pharmaceutical

medications should be inhaled by vaporization" as this would not go through the
digestive tract. Here, the liver metabolism creates havoc with traditional
pharmaceutical medications - thus "unwanted side effects" of many traditional
medications. 

We are looking at clinical research and development programs with this type of
Vaporized delivery - and we look forward to hearing your anecdotal stories of
success with patients.
Vape Shows Immediate Uptake

Immediate health and wellness effects can be seen - particularly in terms of

relaxation and focus. The lungs have CB1 receptor sites and potential immediate
entry into the cardio-pulmonary system may hold future "therapeutic" promise.

Potentially there are benefits for the brain as well, again with the seemingly
"immediate uptake". 

Our research will show this potential benefit and to this, we have hired a
pedigreed pharmaceutical development expert to assist us in better quantifying
these health and wellness benefits. We look forward to further presentations to
our growing team of Kannaway Brand Ambassadors...! 
Hemp Vap Terpenes and Info
HempVAP New Cartridge Contains:
100 mgs CBD in the new HempVAP cartridge

Pure CBD Oil plus MCT Oil

Essential Oils:
• Alpha-Pinene
• Myrcene
• Limonene
• Linalool

NONE OF THESE:
• Propylene-glycol
• Glycerin
• Other additives
Hemp Vap Terpenes
Our new HempVAP line contains the following common
Cannabis Plant terpenes:

Alpha-Pinene Myrcene Limonene Linalool

Hemp Vap Terpenes
Alpha-Pinene (Pine trees – characteristic scent; found in Rosemary and Cannabis)
Characteristics:
• Pine scent, a common terpene in the plant world
• Found in cannabis marijuana strains: Jack Herer and Bubba Kush

Notes:
CRUCIAL for humans as it forms the base for increased CB2 receptor (immune system) activity in our
Endogenous Cannabinoid System

Uses:
Bronchodilator by increasing airflow to the lungs

Medicinal application:
• Bronchodilator
• Analgesic – decreases pain
• Anti-inflammatory
• Increases memory retention
Hemp Vap Terpenes
Myrcene (the most abundant of the cannabis terpenes)

Characteristics: Medicinal application:

• Found in hops, heavily hopped beers, basil, • Increases the permeability of brain cells
mango’s and cannabis membranes to cannabinoids
• Responsible for the “sleep / couch-lock” • Analgesic – reduces pain
effect of cannabis, especially in edibles
• Many cannabis users eat a ripe mango ½ • Anti-bacterial
hour before consuming cannabis • Anti-diabetic
• This increases the “effect” of cannabis • Anti-inflammatory
• Anti-insomnia
Notes: • Suppresses muscle spasms
Folk remedy for diabetes, dysentery, diarrhea,
• Sedative properties
and hypertension


Uses:
Has been shown to synergize the anti-biotic
potential of other terpenes
Hemp Vap Terpenes
Limonene (rinds of the citrus fruit) but common to be found in cannabis

Characteristics:
Citrus odor and flavor

Notes:
Stimulates the immune system in potential anti-cancer benefits, particularly Glioblastoma

Uses:
Used in perfumes and household cleaners

Medicinal applications:
• Promotes weight loss
• Aids in Digestion
• Prevents gastric distress
• Anti-fungal
• Aids with anxiety and depression
Hemp Vap Terpenes
Linalool (Lavender Plant) – found in cannabis

Characteristics: Medicinal applications:

Carries a distinct scent and flavor • Relieves pain
• Anti-depressant
Notes:
• Linalool is crucial in the body’s production of • Anti-epileptic
Vitamin E which improves immune function • Anti-inflammatory
• GW Pharmaceutical’s Sativex product • Anxiolytic – decreases anxiety
contains significant amounts of Linalool • Sedative – promotes sleep
• Cannabis strain Grandaddy Purp contains
significant amounts of Linalool

Uses:
Used in aromatherapy as a sleep aid, relaxant
and treatment for anxiety
Kannaway Essential Oils Terpenes

The new Essential Oil line contains:

Immunity with Limonene Energy with 
 Tranquility with Linalool

Beta-Caryophyllene

All are terpenoids common to the Cannabis Plant Family!

Essential Oil - Immunity
Limonene (rinds of the citrus fruit) but common to be found in cannabis

Characteristics:
Citrus odor and flavor

Notes:
Stimulates the immune system in potential anti-cancer benefits, particularly Glioblastoma

Uses:
Used in perfumes and household cleaners

Medicinal applications:
• Promotes weight loss
• Aids in Digestion
• Prevents gastric distress
• Anti-fungal
• Aids with anxiety and depression
Essential Oil - Energy
Beta-Caryophyllene (Black Pepper) but also quite common in cannabis

Characteristics:
Contributes to the spiciness of black pepper, cloves, hops and rosemary

Notes:
Carries cannabinoid-like effects

Uses:
The chemical structure has led biotech concerns to research its potential anti-cancer applications.

Medicinal applications:
• Anti-oxidant
• Anti-inflammatory
• Anti-cancer
• Local anesthetic effects
• Neuro-protective
• Anti-alcohol abuse effects
• Potential Diabetes benefits
Essential Oil - Tranquility
Linalool (Lavender Plant) – found in cannabis

Characteristics: Medicinal applications:

Carries a distinct scent and flavor • Relieves pain
• Anti-depressant
Notes:
• Linalool is crucial in the body’s production of • Anti-epileptic
Vitamin E which improves immune function • Anti-inflammatory
• GW Pharmaceutical’s Sativex product • Anxiolytic – decreases anxiety
contains significant amounts of Linalool • Sedative – promotes sleep
• Cannabis strain Grandaddy Purp contains
significant amounts of Linalool

Uses:
Used in aromatherapy as a sleep aid, relaxant
and treatment for anxiety