You are on page 1of 679

1 - TOXLINE

TI - Arsenic Exposure in Relation to Ischemic Stroke: The Reasons for


Geographic and Racial Differences in Stroke Study.
AU - Tsinovoi CL
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Xun P
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - McClure LA
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Carioni VMO
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Brockman JD
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Cai J
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Guallar E
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Cushman M
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Unverzagt FW
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - Howard VJ
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.).
AU - He K
AD - From the Departments of Epidemiology and Biostatistics (C.L.T., P.X., K.H.)
and Psychiatry (F.W.U.), Indiana University, Bloomington; Department of
Epidemiology and Biostatistics, Drexel University, Philadelphia, PA (L.A.M.);
University of Missouri Research Reactor Center, University of Missouri, Columbia
(V.M.O.C., J.D.B.); Department of Biostatistics, University of North Carolina at
Chapel Hill (J.C.); Department of Epidemiology, Johns Hopkins University,
Baltimore, MD (E.G.); Department of Medicine, Larner College of Medicine at the
University of Vermont, Burlington (M.C.); and Department of Epidemiology,
University of Alabama at Birmingham (V.J.H.). kahe@indiana.edu.
SO - Stroke. 2018, 01; 49(1):19-26. [Stroke]
AB - BACKGROUND AND PURPOSE: The purpose of this case-cohort study was to
examine urinary arsenic levels in relation to incident ischemic stroke in
the United States.
AB - METHODS: We performed a case-cohort study nested within the REGARDS
(REasons for Geographic and Racial Differences in Stroke) cohort. A
subcohort (n=2486) of controls was randomly sampled within region-race-sex
strata while all incident ischemic stroke cases from the full REGARDS
cohort (n=671) were included. Baseline urinary arsenic was measured by
inductively coupled plasma-mass spectrometry. Arsenic species, including
urinary inorganic arsenic and its metabolites monomethylarsonic acid and
dimethylarsinic acid, were measured in a random subset (n=199). Weighted
Cox's proportional hazards models were used to calculate hazard ratios and
95% confidence intervals of ischemic stroke by arsenic and its species.
AB - RESULTS: The average follow-up was 6.7 years. Although incident ischemic
stroke showed no association with total arsenic or total inorganic
arsenic, for each unit higher level of urinary monomethylarsonic acid on a
log-scale, after adjustment for potential confounders, ischemic stroke
risk increased ≈2-fold (hazard ratio=1.98; 95% confidence interval:
1.12-3.50). Effect modification by age, race, sex, or geographic region
was not evident.
AB - CONCLUSIONS: A metabolite of arsenic was positively associated with
incident ischemic stroke in this case-cohort study of the US general
population, a low-to-moderate exposure area. Overall, these findings
suggest a potential role for arsenic methylation in the pathogenesis of
stroke, having important implications for future cerebrovascular research.
KW - *arsenic
KW - *environment exposures
KW - *minerals
KW - *monomethylarsonic acid
KW - *risk
KW - *stroke
KW - *trace elements
RN - J37VJ5709S
RN - N712M78A8G
LA - eng
IS - 1524-4628 (Electronic)
PT - Journal Article
PT - Multicenter Study
PT - Randomized Controlled Trial
PT - Research Support, N.I.H., Extramural
PT - Research Support, U.S. Gov't, Non-P.H.S.
TA - Stroke
YR - 2018
DATE- 20180315
CI - © 2017 American Heart Association, Inc.
CITO- NLM
CS - United States
CSET- IM
FJT - Stroke
EDAT- 20171206
STAT- MEDLINE
CM - Cites: Curr Atheroscler Rep. 2012 Dec;14(6):542-55 (medline /22968315)
CM - Cites: Sci Prog. 1999;82 ( Pt 1):69-88 (medline /10445007)
CM - Cites: Environ Res. 1993 Feb;60(2):161-77 (medline /8472646)
CM - Cites: Toxicol Lett. 2002 Jul 7;133(1):1-16 (medline /12076506)
CM - Cites: Neuroepidemiology. 2005;25(3):135-43 (medline /15990444)
CM - Cites: Biometrics. 1994 Dec;50(4):1064-72 (medline /7786988)
CM - Cites: Am J Epidemiol. 2007 Dec 15;166(12):1381-91 (medline /17875584)
CM - Cites: Ann Intern Med. 2013 Nov 19;159(10):649-59 (medline /24061511)
CM - Cites: Stroke. 2010 Nov;41(11):2499-504 (medline /20947858)
CM - Cites: Talanta. 2017 Apr 1;165:76-83 (medline /28153322)
CM - Cites: Toxicol Appl Pharmacol. 2010 Sep 1;247(2):138-45 (medline
/20600216)
CM - Cites: Environ Health. 2007 Jan 18;6:1 (medline /17233918)
CM - Cites: Am J Epidemiol. 2012 Jun 15;175(12):1252-61 (medline /22534204)
CM - Cites: Int J Environ Res Public Health. 2009 Mar;6(3):1107-23 (medline
/19440436)
CM - Cites: Arch Toxicol. 2000 Aug;74(6):289-99 (medline /11005674)
CM - Cites: J Environ Qual. 2014 Jan;43(1):379-88 (medline /25602572)
CM - Cites: Ann Neurol. 2011 Apr;69(4):619-27 (medline /21416498)
CM - Cites: J Chromatogr Sci. 1999 Sep;37(9):330-44 (medline /10497786)
CM - Cites: Circulation. 2016 Jan 26;133(4):447-54 (medline /26811276)
CM - Cites: Environ Int. 2012 Feb;39(1):150-71 (medline /22208756)
CM - Cites: Am J Kidney Dis. 2008 Aug;52(2):227-34 (medline /18585836)
CM - Cites: Biometrics. 2004 Dec;60(4):1015-24 (medline /15606422)
CM - Cites: Int J Hyg Environ Health. 2015 Aug;218(6):564-74 (medline
/26118750)
CM - Cites: Environ Health. 2007 Feb 02;6:4 (medline /17274811)
CM - Cites: Water Res. 2010 Nov;44(19):5770-6 (medline /20561663)
CM - Cites: Environ Health Perspect. 2013 Jul;121(7):832-8 (medline /23665672)
CM - Cites: Environ Health Perspect. 2003 Aug;111(11):1429-38 (medline
/12928151)
CM - Cites: Stroke. 1995 Jul;26(7):1145-9 (medline /7604404)
CM - Cites: Stroke. 2001 Oct;32(10):2213-20 (medline /11588303)
CM - Cites: Stroke. 1997 Sep;28(9):1717-23 (medline /9303014)
CM - Cites: Environ Health Perspect. 2009 Sep;117(9):1428-33 (medline
/19750109)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):327-35 (medline
/15276412)
CM - Cites: Environ Res. 2012 Feb;113:52-7 (medline /22341486)
CM - Cites: Sci Total Environ. 1985 Jun;43(3):255-83 (medline /4012298)
CM - Cites: BMC Public Health. 2014 Feb 18;14:174 (medline /24548416)
CM - Cites: N Engl J Med. 1999 Jan 14;340(2):115-26 (medline /9887164)
CM - Cites: Environ Res. 2010 Jul;110(5):448-54 (medline /19880104)
CM - Cites: Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20656-60 (medline
/22143778)
CM - Cites: Int J Environ Res Public Health. 2009 Mar;6(3):1010-25 (medline
/19440430)
CM - Cites: BMJ. 2011 May 05;342:d2431 (medline /21546419)
CM - Cites: Environ Res. 2005 Oct;99(2):164-8 (medline /16194666)
CM - Cites: Stroke. 1997 May;28(5):936-40 (medline /9158628)
CM - Cites: Toxicology. 2000 Jul 5;147(3):157-66 (medline /10924798)
CM - Cites: Stroke. 2013 Jul;44(7):1909-14 (medline /23743971)
DOCNO- medline/29212736

2 - TOXLINE
TI - Arsenic Speciation and Accumulation in Selected Organs after Oral
Administration of Rice Extracts in Wistar Rats.
AU - Lewchalermvong K
AD - Center of Excellence on Environmental Health and Toxicology (EHT) , Ministry
of Education , Bangkok 10400 , Thailand.
AU - Rangkadilok N
AD - Center of Excellence on Environmental Health and Toxicology (EHT) , Ministry
of Education , Bangkok 10400 , Thailand.
AU - Nookabkaew S
AD - Center of Excellence on Environmental Health and Toxicology (EHT) , Ministry
of Education , Bangkok 10400 , Thailand.
AU - Suriyo T
AD - Center of Excellence on Environmental Health and Toxicology (EHT) , Ministry
of Education , Bangkok 10400 , Thailand.
AU - Satayavivad J
AD - Center of Excellence on Environmental Health and Toxicology (EHT) , Ministry
of Education , Bangkok 10400 , Thailand.
SO - J Agric Food Chem. 2018, Mar 28; 66(12):3199-3209. [Journal of
agricultural and food chemistry]
AB - Despite its nutritional values, rice also contains arsenic. There has been
increasing concern about health implications associated with exposure to
arsenic through rice consumption. The present study evaluated arsenic
accumulation and its speciation in selected organs of Wistar rats after 28
day repeated oral administrations of polished or unpolished rice and their
control arsenic compounds (sodium arsenite or dimethylarsinic acid; DMA).
Only the treatment of sodium arsenite (2 μg/kg body weight),
significantly increased total arsenic concentrations in blood when
compared to the distilled water control group. In all groups, total
arsenic concentrations were highest in kidney (1.54-1.90 mg/kg) followed
by liver (0.85-1.52 mg/kg), and the predominant arsenic form in these
organs was DMA. However, there was no significant difference in arsenic
accumulation in the measured organs among the control and rice-treated
groups. Therefore, the repeated 28 day administration of
arsenic-contaminated rice did not cause significant arsenic accumulation
in the animal organs.
KW - arsenic accumulation
KW - arsenic speciation
KW - arsenic-contaminated rice
KW - rice extract
RN - N712M78A8G
LA - eng
IS - 1520-5118 (Electronic)
PT - Journal Article
TA - J Agric Food Chem
YR - 2018
DATE- 20180416
CITO- NLM
CS - United States
CSET- IM
FJT - Journal of agricultural and food chemistry
EDAT- 20180319
STAT- MEDLINE
DOCNO- medline/29526085

3 - TOXLINE
TI - Dose and Diet - Sources of Arsenic Intake in Mouse in Utero Exposure
Scenarios.
AU - Murko M
AD - Institute of Chemistry, NAWI Graz, University of Graz , 8010 Graz, Austria.
AU - Elek B
AD - Pharmacokinetics Branch, Integrated Systems Toxicology Division, National
Health and Environmental Effects Laboratory, Office of Research and Development,
United States Environmental Protection Agency , Research Triangle Park, North
Carolina 27709, United States.
AU - Styblo M
AD - Department of Nutrition, Gillings School of Global Public Health, The
University of North Carolina , Chapel Hill, North Carolina 27719, United States.
AU - Thomas DJ
AD - Pharmacokinetics Branch, Integrated Systems Toxicology Division, National
Health and Environmental Effects Laboratory, Office of Research and Development,
United States Environmental Protection Agency , Research Triangle Park, North
Carolina 27709, United States.
AU - Francesconi KA
AD - Institute of Chemistry, NAWI Graz, University of Graz , 8010 Graz, Austria.
SO - Chem Res Toxicol. 2018, Feb 19; 31(2):156-164. [Chemical research in
toxicology]
AB - In humans, early life exposure to inorganic arsenic is associated with
adverse health effects. Inorganic arsenic in utero or in early postnatal
life also produces adverse health effects in offspring of pregnant mice
that consumed drinking water containing low part per billion levels of
inorganic arsenic. Because aggregate exposure of pregnant mice to
inorganic arsenic from both drinking water and food has not been fully
evaluated in experimental studies, quantifying arsenic exposure of the
developing mouse is problematic. Here, we determined levels of total
arsenic and arsenic species in natural ingredient rodent diets that are
composed of many plant and animal-derived foodstuffs and in a purified
ingredient rodent diet that is composed of a more restricted mixture of
foodstuffs. In natural ingredient diets, total arsenic levels ranged from
∼60 to ∼400 parts per billion, and in the purified ingredient
diet, total arsenic level was 13 parts per billion. Inorganic arsenic was
the predominant arsenic species in trifluoroacetic acid extracts of each
diet. Various exposure scenarios were evaluated using information on
inorganic arsenic levels in diet and drinking water and on daily food and
water consumption of pregnant mice. In a scenario in which pregnant mice
consumed drinking water with 10 parts per billion of inorganic arsenic and
a natural ingredient diet containing 89 parts per billion of inorganic
arsenic, drinking water contributed only ∼20% of inorganic arsenic
intake. Quantitation of arsenic species in diets used in studies in which
drinking water is the nominal source of arsenic exposure provides more
accurate dosimetry and improves understanding of dose-response relations.
Use of purified ingredient diets will minimize the discrepancy between the
target dosage level and the actual dosage level attained in utero exposure
studies designed to evaluate effects of low level exposure to inorganic
arsenic.
LA - eng
IS - 1520-5010 (Electronic)
PT - Journal Article
TA - Chem Res Toxicol
YR - 2018
DATE- 20180219
CITO- NLM
CS - United States
FJT - Chemical research in toxicology
EDAT- 20180102
STAT- In-Data-Review
DOCNO- medline/29244955

4 - TOXLINE
TI - Remediation of arsenic in mung bean (Vigna radiata) with growth
enhancement by unique arsenic-resistant bacterium Acinetobacter lwoffii.
AU - Das J
AD - Biosensor Laboratory, Department of Polymer Science and Technology,
University of Calcutta, 92, A.P.C. Road, Kolkata 700009, West Bengal, India.
AU - Sarkar P
AD - Biosensor Laboratory, Department of Polymer Science and Technology,
University of Calcutta, 92, A.P.C. Road, Kolkata 700009, West Bengal, India;
Department of Chemical Engineering, Calcutta Institute of Technology, Banitabla,
Kolkata 711316, West Bengal, India. Electronic address: principalcit@bciedu.org.
SO - Sci Total Environ. 2018, May 15; 624:1106-1118. [The Science of the total
environment]
AB - Arsenic, a carcinogenic and toxic contaminant of soil and water, affects
human health adversely. During last few decades, it has been an important
global environmental issue. Among several arsenic detoxification methods
remediation using arsenic resistant microbes is proved to be
environment-friendly and cost-effective. This study aimed to test the
effects of arsenic utilizing bacterial strain Acinetobacter lwoffii
(RJB-2) on arsenic uptake and growth of mung bean plants (Vigna radiata).
RJB-2 exhibited tolerance up to 125mM of arsenic (V) and 50mM of arsenic
(III). RJB-2 produced plant growth promoting substances e.g. indole acetic
acid (IAA), siderophores, exopolysaccharide (EPS) and phosphate
solubilization in the absence and in presence of arsenic. Pot experiments
were used to scrutinize the role of RJB-2 on arsenic uptake and growth of
mung bean plants grown in soil amended with 22.5mgkg-1 of sodium arsenate
(Na2HAsO4·7H2O). RJB-2 could arrest arsenic uptake in just 7days
and increase plant growth, number of plants per pot, chlorophyll and
carotenoid content of the mung bean plants. RJB-2 formed biofilm and its
root-association helped to abate arsenic uptake in mung bean. Confocal and
light microscopic studies also revealed the abatement of arsenic uptake
and increase in chlorophyll content in mung bean plants in presence of
RJB-2. RJB-2 was also responsible for less production of reactive oxygen
species (ROS) in mung bean plants reducing the oxidative damage caused by
arsenic. The lower percentage of electrolytic leakage (EL) in RJB-2
inoculated mung bean plants proved arsenic abatement. The study also
reported the distribution of arsenic in various parts of mung bean plant.
RJB-2 owing to its intrinsic abilities of plant growth promotion even in
presence of high concentrations of arsenic could inhibit arsenic uptake
completely and therefore it could be used in large-scale cultivation for
phytostabilization of plants.
KW - Acinetobacter lwoffii
KW - Arsenic remediation
KW - Arsenic uptake
KW - Confocal microscopy
KW - Plant growth
KW - Vigna radiata
RN - N712M78A8G
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180614
CI - Copyright © 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20171227
STAT- MEDLINE
DOCNO- medline/29625525

5 - TOXLINE
TI - A novel fungal arsenic methyltransferase, WaarsM reduces grain arsenic
accumulation in transgenic rice (Oryza sativa L.).
AU - Verma S
AD - Genetics and Molecular Biology Division, CSIR-National Botanical Research
Institute, India.
AU - Verma PK
AD - Genetics and Molecular Biology Division, CSIR-National Botanical Research
Institute, India.
AU - Meher AK
AD - Environmental Material Division, CSIR-National Environmental Engineering
Research Institute, India.
AU - Bansiwal AK
AD - Environmental Material Division, CSIR-National Environmental Engineering
Research Institute, India.
AU - Tripathi RD
AD - Plant Ecology and Environmental Science Division, CSIR-National Botanical
Research Institute, India.
AU - Chakrabarty D
AD - Genetics and Molecular Biology Division, CSIR-National Botanical Research
Institute, India. Electronic address: chakrabartyd@nbri.res.in.
SO - J Hazard Mater. 2018, Feb 15; 344(4):626-634. [Journal of hazardous
materials]
AB - Rice (Oryza sativa L.) grown on arsenic-containing soil and water become a
primary dietary source of arsenic and pose a significant health risk. Gene
modification is an important and practical approach to reduce arsenic
accumulation in rice grains. Here, we reported a WaarsM gene of soil
fungus Westerdykella aurantiaca, expressed in rice able to convert toxic
inorganic arsenicals to methylated arsenic species, therefore, reduce
arsenic accumulation in rice grains. In response to arsenic treatment in
hydroponics, WaarsM expressing transgenic lines showed a marked increase
in arsenic resistance and reduces its accumulation compared to NT. Also,
WaarsM expressing transgenic Line 1 evolved ca. 157ng and ca. 43ng
volatile arsenicals (mg-1 fresh weight) after 72h of exposure to 25μM
AsIII and 250μM AsV, respectively. Transgenic Line 1, grown in soil
irrigated with arsenic-containing water accumulates about 50% and 52%
lower arsenic than NT in shoot and root, respectively; while arsenic
concentration in polished seeds and husk of the transgenic line was
reduced by 52% compared to NT. Thus, the present study demonstrates that
the expression of WaarsM in rice induces arsenic methylation and
volatilization, provides a potential strategy to reduce arsenic
accumulation in rice grain.
KW - Arsenic
KW - Arsenic methyltransferase
KW - Rice
KW - Speciation
KW - Volatilization
LA - eng
IS - 1873-3336 (Electronic)
PT - Journal Article
TA - J Hazard Mater
YR - 2018
DATE- 20180103
CI - Copyright © 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of hazardous materials
EDAT- 20171028
STAT- In-Process
DOCNO- medline/29112921

6 - TOXLINE
TI - sEcad and EGF Levels Increased in Urine of Non-ferrous Metal Workers and
Medium of Uroepithelial Cell Line Treated by Arsenic.
AU - Liu J
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
110122, Liaoning Province, People's Republic of China.
AU - Jin P
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
110122, Liaoning Province, People's Republic of China.
AU - Liu S
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
110122, Liaoning Province, People's Republic of China.
AU - Wang F
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
110122, Liaoning Province, People's Republic of China.
AU - Wang X
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
110122, Liaoning Province, People's Republic of China.
AU - Yang L
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
110122, Liaoning Province, People's Republic of China.
AU - Xi S
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
110122, Liaoning Province, People's Republic of China. shxi@cmu.edu.cn.
SO - Biol Trace Elem Res. 2018, May; 183(1):32-39. [Biological trace element
research]
AB - Inorganic arsenic (iAs) is a carcinogen and could increase the risks of
bladder, lung, and skin cancer. Mining and smelting of non-ferrous metals
are common occupational arsenic exposures. In this study, 125 individuals
working in non-ferrous metal smelting plants were separated into two
groups according to urinary total arsenic (TAs) levels: group 1,
TAs < 100 &mu;g/g Cr; group 2,
TAs &ge; 100 &mu;g/g Cr. Demographic characteristics of
participants were obtained by questionnaire interview. Levels of
E-cadherin soluble ectodomain fragment (sEcad) and epidermal growth factor
(EGF) in workers urine were determined by ELISA test. We found that
concentrations of sEcad and EGF present in urine were significantly
elevated in the high urinary arsenic group 2 compared with the low urinary
arsenic group 1. Urinary levels of the shedding of E-cadherin soluble
ectodomain fragment (sEcad) and epidermal growth factor (EGF) were
positively related to the concentrations of iAs in urine after adjusting
for the confounding effects. A positive correlation between sEcad and EGF
concentrations in urine was also observed. In order to verify the effects
of iAs on sEcad and EGF, the human uroepithelial cell line (SV-HUC-1) was
treated with NaAsO2 for 24 h in vitro. sEcad and EGF levels in the
4 &mu;M NaAsO2-treated SV-HUC-1 cell medium significantly increased
compared to the control group. In conclusion, urinary levels of sEcad and
EGF increased in higher urinary arsenic workers of non-ferrous metal
plants and are closely associated with urinary iAs concentration. The
results suggested that sEcad and EGF may potentially be preclinical
prognostic factors of bladder injury and early detection in arsenic
exposure individuals.
KW - Arsenic
KW - EGF
KW - Non-ferrous metals
KW - Uroepithelial cells
KW - sEcad
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180406
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170817
STAT- In-Process
DOCNO- medline/28819764

7 - TOXLINE
TI - Metabolomic assessment of arsenite toxicity and novel biomarker discovery
in early development of zebrafish embryos.
AU - Wu SY
AD - Department of Radiation Oncology, Wan Fang Hospital, Taipei Medical
University, Taipei, Taiwan; Department of Internal Medicine, School of Medicine,
College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute
of Biotechnology, Chinese Culture University, YangMingShan, Taipei 11114, Taiwan.
AU - Phan NN
AD - Graduate Institute of Biotechnology, Chinese Culture University,
YangMingShan, Taipei 11114, Taiwan; NTT Institute of Hi-Technology, Nguyen Tat
Thanh University, Ho Chi Minh City, Vietnam.
AU - Ho SH
AD - State Key Lab of Urban Water Resource and Environment, Harbin Institute of
Technology, Harbin, 150090, China.
AU - Lai YH
AD - Department of Chemistry, Chinese Culture University, YangMingShan, Taipei
11114, Taiwan.
AU - Tsai CH
AD - Yu-kang Animal Hospital, Taipei City, Taiwan.
AU - Yang CH
AD - Taiwan Hi-Q Marine Biotech International Ltd, Taiwan.
AU - Yu HG
AD - Graduate Institute of Biotechnology, Chinese Culture University,
YangMingShan, Taipei 11114, Taiwan.
AU - Wang JC
AD - Graduate Institute of Biotechnology, Chinese Culture University,
YangMingShan, Taipei 11114, Taiwan.
AU - Huang PL
AD - Graduate Institute of Biotechnology, Chinese Culture University,
YangMingShan, Taipei 11114, Taiwan.
AU - Lin YC
AD - Graduate Institute of Biotechnology, Chinese Culture University,
YangMingShan, Taipei 11114, Taiwan. Electronic address: LYC10@ulive.pccu.edu.tw.
SO - Toxicol Lett. 2018, Jun 15; 290:116-122. [Toxicology letters]
AB - CONTEXT: Arsenic poisoning commonly occurs through exposure to water
contaminated with arsenic and causes long-term symptoms. Of all the
arsenic derivatives, arsenite is the one of the most toxic compounds.
However, the toxicity of arsenite during developmental stages is still
unclear.
AB - OBJECTIVE: In this study, we performed a metabolomic analysis of arsenite
responses in embryonic zebrafish.
AB - MATERIALS AND METHODS: Embryonic zebrafish were used as an animal model in
this study. They were exposed to sodium arsenite under different
concentrations (0.5, 1.0, 2.0, and 5.0&#8239;mg/L) in 24&#8239;h,
48&#8239;h and 72&#8239;h post fertilization. Changes in morphology were
observed through a light microscope. Changes in metabolomics were
identified using an ultraperformance liquid chromatography quadrupole
time-of-flight system.
AB - RESULTS: The IC50 range was 0.75&#8239;&plusmn;&#8239;0.25&#8239;mg/L.
Compared with the control group, the embryonic lethality rate decreased to
33.3% under 1.0&#8239;mg/L of arsenite treatment, whereas it decreased to
20.0% under 2.0&#8239;mg/L of arsenite treatment. Numerous body axis
curvatures were also observed under treatment with 2.0 and 5.0&#8239;mg/L
of arsenic. Pericardium and yolk sac edema were randomly discovered and
found to worsen over time. Moreover, the 10 metabolites with the highest
variable importance in projection score were identified as potential
biomarkers for arsenic exposure.
AB - CONCLUSION: Arsenic exposure not only leads to a change in the morphology
of embryonic zebrafish but also disturbs the metabolism of zebrafish in
early developmental stages.
KW - Embryonic zebrafish
KW - Metabolomic analysis
KW - Sodium arsenite
RN - 8D239QDW64
RN - N5509X556J
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20180501
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Toxicology letters
EDAT- 20180315
STAT- MEDLINE
DOCNO- medline/29551592

8 - TOXLINE
TI - Metabolism and disposition of arsenic species from controlled oral dosing
with sodium arsenite in adult female CD-1 mice. I. Pilot study to
determine dosing, analytical measurements, and sampling strategies.
AU - Twaddle NC
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
AU - Vanlandingham M
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
AU - Churchwell MI
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
AU - Doerge DR
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
Electronic address: daniel.doerge@fda.hhs.gov.
SO - Food Chem Toxicol. 2018, Jan; 111:482-493. [Food and chemical toxicology :
an international journal published for the British Industrial Biological
Research Association]
AB - Arsenic (As) is ubiquitous in the earth's crust, with typical dietary
intake in developed countries < 1 &mu;g/kg bw/d, and atypical
groundwater exposures in developing countries approaching
50 &mu;g/kg bw/d. Arsenic exposures are linked with human
diseases and doses of toxicological concern are similar to typical dietary
intake estimates. The methylation of arsenite by
arsenite-3-methyltransferase (As3MT) promotes the clearance of arsenic as
pentavalent species, but also generates reactive trivalent intermediates.
This study measured inorganic arsenic and its metabolites in pentavalent
and trivalent states in blood, tissues, and excreta after oral
administration of arsenite (50-200 &mu;g/kg bw). While liver was a
major site for clearance of arsenite and formation of methylated species,
it also had extensive binding of trivalent intermediates; however, thiol
exchange and oxidation reactions of trivalent arsenic were facile since
dimethylarsinic acid (DMAV) was the predominant species in blood and
urine. Consistent evidence was observed for a non-linear relationship
between doses above 50 &mu;g/kg bw and levels of bound trivalent As
metabolites. The abundance of protein-bound trivalent arsenic within
target tissues should correlate with disruption of critical cellular
processes, which rely on defined interactions of thiol functional groups,
and could provide dose-response relationships from animal models for human
risk assessment.
KW - Arsenic
KW - ICP/MS
KW - Metabolism
KW - Toxicokinetics
RN - 48OVY2OC72
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180507
CI - Copyright &copy; 2017. Published by Elsevier Ltd.
CITO- NLM
CS - England
CSET- IM
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20171205
STAT- MEDLINE
DOCNO- medline/29217265

9 - TOXLINE
TI - Speciation and bioaccessibility of arsenic in traditional Chinese
medicines and assessment of its potential health risk.
AU - Liu L
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China.
AU - Zhang Y
AD - Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102,
China.
AU - Yun Z
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China.
AU - He B
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; College of Resources and Environment, University of Chinese Academy of
Sciences, Beijing 100049, China. Electronic address: bhe@rcees.ac.cn.
AU - Zhang Q
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; College of Resources and Environment, University of Chinese Academy of
Sciences, Beijing 100049, China.
AU - Hu L
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; College of Resources and Environment, University of Chinese Academy of
Sciences, Beijing 100049, China.
AU - Jiang G
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; College of Resources and Environment, University of Chinese Academy of
Sciences, Beijing 100049, China.
SO - Sci Total Environ. 2018, Apr 01; 619-620:1088-1097. [The Science of the
total environment]
AB - Arsenic in traditional Chinese medicines (TCMs) has caused public concerns
about its health risk in recent years due to the high toxicity of arsenic
and widespread use of those medicines throughout the world. However, in
previous studies the arsenic toxicity was usually overestimated by
considering the total arsenic concentration only. This work investigated
the total concentration, speciation and bioaccessibility of arsenic in 84
commonly used traditional Chinese patent medicines (CPMs) and Chinese
herbal medicines (CHMs) to evaluate arsenic's potential health risks to
human. Arsenic was found in all the CPMs and 88% of CHMs at concentrations
ranging from 0.033 to 91,000mgkg-1 and 0.012 to 6.6mgkg-1, respectively.
The bioaccessibility of arsenic varied significantly and was in the range
of 0.21%-90% in the CPMs and 15%-96% in the CHMs, with inorganic arsenic
as the predominant species. The average daily intake dose (ADD) and hazard
quotient (HQ) of arsenic in most of medicines were within the safe limits,
while in certain medicines, they exceeded the safe threshold level. These
excesses remind us that the potential health risk by consumption of
several medicines may not be negligible and more control and monitoring of
arsenic in medicines should be carried out.
KW - Arsenic
KW - Bioaccessibility
KW - Simulated gastrointestinal digestion
KW - Speciation
KW - Traditional Chinese medicine
RN - N712M78A8G
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180607
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20171129
STAT- MEDLINE
DOCNO- medline/29734587

10 - TOXLINE
TI - A study of telomere length, arsenic exposure, and arsenic toxicity in a
Bangladeshi cohort.
AU - Zhang C
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States; Department of Epidemiology and Biostatistics, University of
California, San Francisco, San Francisco, CA 94158, United States.
AU - Kibriya MG
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States.
AU - Jasmine F
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States.
AU - Roy S
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States; Centers for Disease Control and Prevention, Atlanta, GA
30329, United States.
AU - Gao J
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States.
AU - Sabarinathan M
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States.
AU - Shinkle J
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States.
AU - Delgado D
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States.
AU - Ahmed A
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Islam T
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Eunus M
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Islam MT
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Hasan R
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Graziano JH
AD - Department of Environmental Health Sciences, Mailman School of Public Health,
Columbia University, New York, NY 10032, United States.
AU - Ahsan H
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States; Department of Human Genetics, University of Chicago, Chicago,
IL 60615, United States; Comprehensive Cancer Center, University of Chicago,
Chicago, IL 60615, United States; Department of Medicine, University of Chicago,
Chicago, IL 60615, United States.
AU - Pierce BL
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL
60615, United States; Department of Human Genetics, University of Chicago, Chicago,
IL 60615, United States; Comprehensive Cancer Center, University of Chicago,
Chicago, IL 60615, United States. Electronic address: brandonpierce@uchicago.edu.
SO - Environ Res. 2018, Jul; 164:346-355. [Environmental research]
AB - BACKGROUND: Chronic arsenic exposure is associated with increased risk for
arsenical skin lesions, cancer, and other adverse health outcomes. One
potential mechanism of arsenic toxicity is telomere dysfunction. However,
prior epidemiological studies of arsenic exposure, telomere length (TL),
and skin lesion are small and cross-sectional. We investigated the
associations between arsenic exposure and TL and between baseline TL and
incident skin lesion risk among individuals participating in the Health
Effects of Arsenic Longitudinal Study in Bangladesh (2000-2009).
AB - METHODS: Quantitative PCR was used to measure the average TL of peripheral
blood DNA collected at baseline. The association between baseline arsenic
exposure (well water and urine) and TL was estimated in a
randomly-selected subcohort (n&#8239;=&#8239;1469). A nested case-control
study (466 cases and 464 age- and sex-matched controls) was used to
estimate the association between baseline TL and incident skin lesion risk
(diagnosed < &#8239;8 years after baseline).
AB - RESULTS: No association was observed between arsenic exposure (water or
urine) and TL. Among incident skin lesion cases and matched controls, we
observed higher skin lesion risk among individuals with shorter TL (Ptrend
=&#8239;1.5 &times; 10-5) with odds ratios of 2.60, 1.59, and 1.10 for the
first (shortest), second, and third TL quartiles compared to the fourth
(longest).
AB - CONCLUSIONS: Arsenic exposure was not associated with TL among Bangladeshi
adults, suggesting that leukocyte TL may not reflect a primary mode of
action for arsenic's toxicity. However, short TL was associated with
increased skin lesion risk, and may be a biomarker of arsenic
susceptibility modifying arsenic's effect on skin lesion risk.
KW - Arsenic
KW - Bangladesh
KW - Drinking water
KW - Skin lesion
KW - Telomere length
LA - eng
IS - 1096-0953 (Electronic)
PT - Journal Article
TA - Environ Res
YR - 2018
DATE- 20180602
CI - Copyright &copy; 2018. Published by Elsevier Inc.
CITO- NLM
CS - Netherlands
FJT - Environmental research
EDAT- 20180320
STAT- In-Data-Review
DOCNO- medline/29567420

11 - TOXLINE
TI - Effects of Arsenic Compounds on Microminerals Content and Antioxidant
Enzyme Activities in Rat Liver.
AU - Souza ACF
AD - Department of General Biology, Federal University of Vi�osa, Av. P.H. Rolfs,
s/n, Campus Universit�rio, Vi�osa, Minas Gerais, 36570-900, Brazil.
AU - Marchesi SC
AD - Department of General Biology, Federal University of Vi�osa, Av. P.H. Rolfs,
s/n, Campus Universit�rio, Vi�osa, Minas Gerais, 36570-900, Brazil.
AU - de Almeida Lima GD
AD - Department of General Biology, Federal University of Vi�osa, Av. P.H. Rolfs,
s/n, Campus Universit�rio, Vi�osa, Minas Gerais, 36570-900, Brazil.
AU - Machado-Neves M
AD - Department of General Biology, Federal University of Vi�osa, Av. P.H. Rolfs,
s/n, Campus Universit�rio, Vi�osa, Minas Gerais, 36570-900, Brazil.
mariana.mneves@ufv.br.
SO - Biol Trace Elem Res. 2018, Jun; 183(2):305-313. [Biological trace element
research]
AB - Interactions of arsenic with essential trace elements may result in
disturbances on body homeostasis. In the present study, we aimed to
investigate the effects of different arsenic compounds on micromineral
content and antioxidant enzyme activities in rat liver. Male Wistar rats
were randomly divided into five groups and exposed to sodium arsenite and
sodium arsenate at 0.01 and 10 mg/L for 8 weeks in drinking
water. The concentration of arsenic increased in the liver of all
arsenic-exposed animals. The proportion of zinc and copper increased in
animals exposed to 0.01 mg/L sodium arsenite. In addition, these
animals presented a reduction in magnesium and sodium content. Superoxide
dismutase activity decreased mainly in arsenite-exposed animals, whereas
catalase activity decreased in animals exposed to 10 mg/L sodium
arsenate. Further, exposure to sodium arsenate at 10 mg/L altered
copper and magnesium content in the liver, and reduced total protein
levels. Overall, both arsenic compounds altered the liver histology, with
reduction in the proportion of cytoplasm and hepatocyte, and increased the
percentage of sinusoidal capillaries and macrophages. In conclusion, our
findings showed that oral exposure to arsenic compounds disturbs the trace
elements balance in the liver, especially at low concentration, altering
enzymatic and stereological parameters. We concluded that despite the
increase in trace elements content, the antioxidant enzyme activities were
downregulated and did not prevent morphological alterations in the liver
of animals exposed to both arsenic compounds.
KW - Antioxidant defenses
KW - Arsenate
KW - Arsenite
KW - Hepatotoxicity
KW - Mineral microanalysis
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180508
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170906
STAT- In-Process
DOCNO- medline/28879625

12 - TOXLINE
TI - A unique arsenic speciation profile in Elaphomyces spp. ("deer
truffles")-trimethylarsine oxide and methylarsonous acid as significant
arsenic compounds.
AU - Braeuer S
AD - Institute of Chemistry, Analytical Chemistry for Health and Environment,
University of Graz, Universitaetsplatz 1, 8010, Graz, Austria.
AU - Borovi&#269;ka J
AD - The Czech Academy of Sciences, Institute of Geology, Rozvojov� 269, 16500,
Prague 6, Czech Republic.
AU - Goessler W
AD - Institute of Chemistry, Analytical Chemistry for Health and Environment,
University of Graz, Universitaetsplatz 1, 8010, Graz, Austria. walter.goessler@uni-
graz.at.
SO - Anal Bioanal Chem. 2018, Mar; 410(9):2283-2290. [Analytical and
bioanalytical chemistry]
AB - Arsenic and its species were investigated for the first time in nine
collections of Elaphomyces spp. ("deer truffles") from the Czech Republic
with inductively coupled plasma mass spectrometry (ICPMS) and
high-performance liquid chromatography coupled to ICPMS. The total arsenic
concentrations ranged from 12 to 42 mg kg-1 dry mass in samples of E.
asperulus and from 120 to 660 mg kg-1 dry mass in E. granulatus and
E. muricatus. These concentrations are remarkably high for terrestrial
organisms and demonstrate the arsenic-accumulating ability of these fungi.
The dominating arsenic species in all samples was methylarsonic acid which
accounted for more than 30% of the extractable arsenic. Arsenobetaine,
dimethylarsinic acid, and inorganic arsenic were present as well, but only
at trace concentrations. Surprisingly, we found high amounts of
trimethylarsine oxide in all samples (0.32-28% of the extractable
arsenic). Even more remarkable was that all but two samples contained
significant amounts of the highly toxic trivalent arsenic compound
methylarsonous acid (0.08-0.73% of the extractable arsenic). This is the
first report of the occurrence of trimethylarsine oxide and methylarsonous
acid at significant concentrations in a terrestrial organism. Our findings
point out that there is still a lot to be understood about the
biotransformation pathways of arsenic in the terrestrial environment.
Graphical abstract Trimethylarsine oxide and methylarsonous acid in "deer
truffles".
KW - Arsenic speciation
KW - Deer truffles
KW - Elaphomyces
KW - Fungi
KW - Methylarsonous acid
KW - Trimethylarsine oxide
RN - 4964-14-1
RN - J37VJ5709S
LA - eng
IS - 1618-2650 (Electronic)
PT - Journal Article
TA - Anal Bioanal Chem
YR - 2018
DATE- 20180501
CITO- NLM
CS - Germany
CSET- IM
FJT - Analytical and bioanalytical chemistry
EDAT- 20180212
STAT- MEDLINE
CM - Cites: Chem Res Toxicol. 2014 Apr 21;27(4):457-61 (medline /24517124)
CM - Cites: Sci Total Environ. 2007 May 15;377(2-3):308-18 (medline /17391732)
CM - Cites: Chemosphere. 2008 Apr;71(8):1522-30 (medline /18179812)
CM - Cites: J Sep Sci. 2015 Mar;38(6):943-50 (medline /25594186)
CM - Cites: Toxicol Appl Pharmacol. 2000 Mar 1;163(2):203-7 (medline /10698679)
CM - Cites: Analyst. 2004 May;129(5):373-95 (medline /15116227)
CM - Cites: Arch Toxicol. 2013 Jun;87(6):969-79 (medline /22811022)
CM - Cites: Food Chem. 2018 Mar 1;242:225-231 (medline /29037683)
CM - Cites: Arch Environ Contam Toxicol. 2007 Jan;52(1):38-46 (medline
/17031752)
CM - Cites: Chem Res Toxicol. 2000 Aug;13(8):693-7 (medline /10956055)
CM - Cites: Anal Chem. 2008 Feb 1;80(3):775-82 (medline /18181583)
CM - Cites: Analyst. 2003 Jun;128(6):796-802 (medline /12866906)
CM - Cites: Environ Sci Technol. 2014 Dec 16;48(24):14203-10 (medline
/25417842)
CM - Cites: Anal Methods. 2012;4(2):406-413 (medline /22685491)
CM - Cites: Persoonia. 2017 Jun;38:197-239 (medline /29151633)
CM - Cites: Environ Health Perspect. 2013 Mar;121(3):295-302 (medline
/23458756)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016
Oct;34(4):217-232 (medline /27635858)
DOCNO- medline/29430602
13 - TOXLINE
TI - Flavonoids inhibit chronically exposed arsenic-induced proliferation and
malignant transformation of HaCaT cells.
AU - Rajput M
AD - Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru
University, New Delhi, India.
AU - Kujur PK
AD - Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru
University, New Delhi, India.
AU - Mishra A
AD - Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru
University, New Delhi, India.
AU - Singh RP
AD - School of Life Sciences, Central University of Gujarat, Gandhinagar, Gujarat,
India.
SO - Photodermatol Photoimmunol Photomed. 2018, Jan; 34(1):91-101.
[Photodermatology, photoimmunology & photomedicine]
AB - BACKGROUND: Apart from exposure to UV-radiation, studies show relationship
between skin cancer and chronic ingestion of arsenic through drinking
water. Chemopreventive strategies could help in reducing the toxic effects
of arsenic and arsenic-induced skin cancer.
AB - METHODS: Cytotoxicity of arsenic on human skin keratinocytes HaCaT cells
was evaluated using MTT and trypan blue assays. Arsenic-induced malignant
transformant HaCaT cells were selected through soft agar colony assay.
Cell cycle progression was analyzed through FACS. The expressions of genes
modulated by arsenic were studied through RT-PCR.
AB - RESULTS: The lower concentrations (0.1-0.5 &mu;mol/L) of arsenic were
non-toxic and transformed HaCaT cells on chronic exposure, and also
enhanced the cell proliferation. Silibinin and fisetin reduced the
arsenic-induced cell proliferation and malignant transformation. A slight
increase in G2-M phase cell population was also observed. The
anti-proliferation effects of flavonoids on HaCaT transformants were
further enhanced when combined with gamma radiation. Chronic and acute
exposure to arsenic modulated the expression of transformation-associated
genes including Bcl-2A1, IGFL-1, Rab31, and TNC in HaCaT cells.
AB - CONCLUSIONS: Chronic exposure to lower arsenic concentrations caused
malignant transformation of skin keratinocytes and that effect was
attenuated by flavonoids silibinin and fisetin. Thus, chemoprevention
could reduce arsenic-caused detrimental effects on skin cells.
KW - arsenic
KW - chemoprevention
KW - phytochemicals
KW - skin cancer
KW - transformation
LA - eng
IS - 1600-0781 (Electronic)
PT - Journal Article
TA - Photodermatol Photoimmunol Photomed
YR - 2018
DATE- 20180109
CI - &copy; 2017 John Wiley &amp; Sons A/S. Published by John Wiley &amp; Sons
Ltd.
CITO- NLM
CS - England
FJT - Photodermatology, photoimmunology &amp; photomedicine
EDAT- 20171128
STAT- In-Process
DOCNO- medline/29049844
14 - TOXLINE
TI - Assessment of arsenic oxidation potential of Microvirga indica S-MI1b sp.
nov. in heavy metal polluted environment.
AU - Tapase SR
AD - Biochemistry Division, Department of Chemistry, Savitribai Phule Pune
University, Pune, 411007, India.
AU - Kodam KM
AD - Biochemistry Division, Department of Chemistry, Savitribai Phule Pune
University, Pune, 411007, India. Electronic address: kodam@chem.unipune.ac.in.
SO - Chemosphere. 2018, Mar; 195:1-10. [Chemosphere]
AB - Arsenic oxidizing &alpha;-proteobacterial strain Microvirga indica S-MI1b
sp. nov. was isolated from metal industry soil and has the ability to
oxidize 15 mM of arsenite [As(III)] completely in 39 h. The
strain S-MI1b resists to different heavy metals and it oxidizes arsenite
in presence of Li, Pb, Hg, Sb(III), Cd, Cr(VI), Ni, and exhibited growth
inhibitory effect in presence of Hg, Cu, and Cd at higher concentration.
The morphology of Microvirga indica S-MI1b changed in presence of heavy
metals however there was no accumulation of As(III) in the cells. The
study showed that Microvirga indica S-MI1b can oxidize arsenite at broad
pH ranges from 4.0 to 9.0 with optimum at pH 7.0. The kinetic studies of
arsenite oxidation by strain S-MI1b signified that it has greater affinity
towards As(III). The arsenite oxidase activity of cells grown in presence
of Li and Cr(VI) supported the cell culture studies. This is first report
on biotransformation of arsenite by Microvirga genus and also arsenite
oxidation in presence of heavy metals.
KW - Arsenic biotransformation
KW - Arsenite oxidase
KW - Heavy metals
KW - Microvirga indica
RN - N5509X556J
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180515
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171206
STAT- MEDLINE
DOCNO- medline/29241075

15 - TOXLINE
TI - A new aerobic chemolithoautotrophic arsenic oxidizing microorganism
isolated from a high Andean watershed.
AU - Anguita JM
AD - Centro de Desarrollo Urbano Sustentable (CEDEUS), Santiago, Chile.
AU - Rojas C
AD - Institute of Agricultural Sciences, University of O'Higgins, Rancagua, Chile.
AU - Past�n PA
AD - Centro de Desarrollo Urbano Sustentable (CEDEUS), Santiago, Chile.
AU - Vargas IT
AD - Centro de Desarrollo Urbano Sustentable (CEDEUS), Santiago, Chile.
itvargas@ing.puc.cl.
SO - Biodegradation. 2018, 02; 29(1):59-69. [Biodegradation]
AB - Biological arsenic oxidation has been suggested as a key biogeochemical
process that controls the mobilization and fate of this metalloid in
aqueous environments. To the best of our knowledge, only four aerobic
chemolithoautotrophic arsenite-oxidizing (CAO) bacteria have been shown to
grow via direct arsenic oxidation and to have the essential genes for
chemolithoautotrophic arsenite oxidation. In this study, a new CAO
bacterium was isolated from a high Andean watershed evidencing natural
dissolved arsenic attenuation. The bacterial isolate, designated TS-1, is
closely related to the Ancylobacter genus, in the Alphaproteobacteria
class. Results showed that TS-1 has genes for arsenite oxidation and
carbon fixation. The dependence of bacterial growth from arsenite
oxidation was demonstrated. In addition, a mathematical model was
suggested and the kinetic parameters were obtained by simultaneously
fitting the biomass growth, arsenite depletion curves, and arsenate
production. This research increases the knowledge of chemolithoautotrophic
arsenic oxidizing microorganisms and its potential role as a driver for
natural arsenic attenuation.
KW - *Arsenic
KW - *Biogeochemistry
KW - *Biotransformation
KW - *Chemolithoautotrophic arsenite-oxidizing (CAO) bacteria
RN - N712M78A8G
LA - eng
IS - 1572-9729 (Electronic)
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
TA - Biodegradation
YR - 2018
DATE- 20180430
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Biodegradation
EDAT- 20171116
STAT- MEDLINE
DOCNO- medline/29143902

16 - TOXLINE
TI - Decreasing arsenic accumulation in rice by overexpressing OsNIP1;1 and
OsNIP3;3 through disrupting arsenite radial transport in roots.
AU - Sun SK
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing,
210095, China.
AU - Chen Y
AD - Department of Metabolic Biology, John Innes Centre, Norwich Research Park,
Norwich, NR4 7UH, UK.
AU - Che J
AD - Institute of Plant Science and Resources, Okayama University, Chuo 2-20-1,
Kurashiki, 710-0046, Japan.
AU - Konishi N
AD - Institute of Plant Science and Resources, Okayama University, Chuo 2-20-1,
Kurashiki, 710-0046, Japan.
AU - Tang Z
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing,
210095, China.
AU - Miller AJ
AD - Department of Metabolic Biology, John Innes Centre, Norwich Research Park,
Norwich, NR4 7UH, UK.
AU - Ma JF
AD - Institute of Plant Science and Resources, Okayama University, Chuo 2-20-1,
Kurashiki, 710-0046, Japan.
AU - Zhao FJ
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing,
210095, China.
SO - New Phytol. 2018, May 11. [The New phytologist]
AB - Rice is a major dietary source of the toxic metalloid arsenic. Reducing
arsenic accumulation in rice grain is important for food safety. We
generated transgenic rice overexpressing two aquaporin genes, OsNIP1;1 and
OsNIP3;3, under the control of a maize ubiquitin promoter or the rice
OsLsi1 promoter, and tested the effect on arsenite uptake and
translocation. OsNIP1;1 and OsNIP3;3 were highly permeable to arsenite in
Xenopus oocyte assays. Both transporters were localized at the plasma
membrane. Knockout of either gene had little effect on arsenite uptake or
translocation. Overexpression of OsNIP1;1 or OsNIP3;3 in rice did not
affect arsenite uptake but decreased root-to-shoot translocation of
arsenite and shoot arsenic concentration markedly. The overexpressed
OsNIP1;1 and OsNIP3;3 proteins were localized in all root cells without
polarity. Expression of OsNIP1;1 driven by the OsLsi1 promoter produced
similar effects. When grown in two arsenic-contaminated paddy soils,
overexpressing lines contained significantly lower arsenic concentration
in rice grain than the wild-type without compromising plant growth or the
accumulation of essential nutrients. Overexpression of OsNIP1;1 or
OsNIP3;3 provides a route for arsenite to leak out of the stele, thus
restricting arsenite loading into the xylem. This strategy is effective in
reducing arsenic accumulation in rice grain.
KW - Nodulin 26-like Intrinsic Proteins
KW - arsenic
KW - arsenite
KW - radial transport
KW - rice
KW - root-to-shoot translocation
LA - eng
IS - 1469-8137 (Electronic)
PT - Journal Article
TA - New Phytol
YR - 2018
DATE- 20180511
CI - &copy; 2018 The Authors. New Phytologist &copy; 2018 New Phytologist
Trust.
CITO- NLM
CS - England
FJT - The New phytologist
EDAT- 20180511
STAT- Publisher
DOCNO- medline/29749629

17 - TOXLINE
TI - Arsenic concentrations and speciation in wild birds from an abandoned
realgar mine in China.
AU - Yang F
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern
and Simulation, Chinese Academy of Sciences, Beijing, 100101, China; University of
Chinese Academy of Sciences, Beijing, 100049, China.
AU - Xie S
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern
and Simulation, Chinese Academy of Sciences, Beijing, 100101, China; University of
Chinese Academy of Sciences, Beijing, 100049, China.
AU - Liu J
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern
and Simulation, Chinese Academy of Sciences, Beijing, 100101, China; University of
Chinese Academy of Sciences, Beijing, 100049, China.
AU - Wei C
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern
and Simulation, Chinese Academy of Sciences, Beijing, 100101, China. Electronic
address: weicy@igsnrr.ac.cn.
AU - Zhang H
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing, 100101, China.
AU - Chen T
AD - University of Chinese Academy of Sciences, Beijing, 100049, China; Beijing
Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy
of Sciences, Beijing, 100049, China.
AU - Zhang J
AD - Beijing Synchrotron Radiation Facility, Institute of High Energy Physics,
Chinese Academy of Sciences, Beijing, 100049, China.
SO - Chemosphere. 2018, Feb; 193:777-784. [Chemosphere]
AB - Birds are at a higher level in the food chain; however, the potential
bioaccumulation and biotransformation of arsenic (As) in birds in As mines
has rarely been studied. In this study, four passerine bird species (tree
sparrow [Passer montanus], light-vented bulbul [Pycnonotus sinensis],
Garrulax canorus [Leucodioptron canorus], and magpie [Pica pica]) were
collected from an abandoned As mine in China. The highest recorded As
concentrations were 4.95 mg/kg and 51.65 mg/kg in muscles and
feathers, respectively. Detection using high-performance liquid
chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS)
revealed six As species, including arsenite (As(III)), arsenate (As(V)),
dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), arsenobetaine
(AsB) and arsenocholine (AsC), with the former three species as the
dominant ( > 92%) and the latter three as the minor As species
( < 6.17%). Further analysis of the selected bird samples using the X-ray
absorption near edge structure (XANES) technique revealed the existence of
As(III)-tris-glutathione (As(III)-GSH), which can be regarded as
equivalent to the non-extractable and unidentified As form in the
HPLC-ICP-MS data. Both methods revealed similar patterns of As species in
the birds from the As mine, with muscles containing mainly inorganic As
and DMA and feathers containing mainly inorganic As. The results of this
study contribute to the knowledge regarding As accumulation and speciation
in terrestrial organisms.
KW - Arsenic
KW - Feathers
KW - HPLC-ICP-MS
KW - Muscles
KW - XANES
RN - 39895-81-3
RN - 56320-22-0
RN - AJ2HL7EU8K
RN - J37VJ5709S
RN - N5509X556J
RN - N712M78A8G
RN - N7CIZ75ZPN
RN - UWC1LS4V3I
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171120
STAT- MEDLINE
DOCNO- medline/29175405

18 - TOXLINE
TI - Phytofiltration of arsenic by aquatic moss (Warnstorfia fluitans).
AU - Sandhi A
AD - Department of Ecology, Environment and Plant Sciences, Stockholm University,
Svante Arrhenius v�g 20A, SE-106 91 Stockholm, Sweden; Land and Water Resources
Engineering Division, Department of Sustainable Development, Environmental Science
and Engineering, KTH Royal Institute of Technology, Teknikringen 76, SE-100 44
Stockholm, Sweden. Electronic address: asandhi@kth.se.
AU - Landberg T
AD - Department of Ecology, Environment and Plant Sciences, Stockholm University,
Svante Arrhenius v�g 20A, SE-106 91 Stockholm, Sweden.
AU - Greger M
AD - Department of Ecology, Environment and Plant Sciences, Stockholm University,
Svante Arrhenius v�g 20A, SE-106 91 Stockholm, Sweden.
SO - Environ Pollut. 2018, Jun; 237:1098-1105. [Environmental pollution
(Barking, Essex : 1987)]
AB - This work investigates whether aquatic moss (Warnstorfia fluitans)
originating from an arsenic (As)-contaminated wetland close to a mine
tailings impoundment may be used for phytofiltration of As. The aim was to
elucidate the capacity of W. fluitans to remove As from arsenite and
arsenate contaminated water, how nutrients affect the As uptake and the
proportion of As adsorption and absorption by the moss plant, which
consists of dead and living parts. Arsenic removal from 0, 1, or 10%
Hoagland nutrient solution containing 0-100 &mu;M arsenate was
followed over 192 h, and the total As in aquatic moss after treatment
was analysed. The uptake and speciation of As in moss cultivated in water
containing 10 &mu;M arsenate or arsenite were examined as As uptake
in living (absorption + adsorption) and dead (adsorption) plant
parts. Results indicated that W. fluitans removed up to 82% of As
from the water within one hour when 1 &mu;M arsenate was added in the
absence of nutrients. The removal time increased with greater nutrient and
As concentrations. Up to 100 &mu;M As had no toxic effect on the
plant biomass. Both arsenite and arsenate were removed from the solution
to similar extents and, independent of the As species added, more arsenate
than arsenite was found in the plant. Of the As taken up, over 90% was
firmly bound to the tissue, a possible mechanism for resisting high As
concentrations. Arsenic was both absorbed and adsorbed by the moss, and
twice as much As was found in living parts as in dead moss tissue. This
study revealed that W. fluitans has potential to serve as a
phytofilter for removing As from As-contaminated water without displaying
any toxic effects of the metalloid.
KW - Absorption
KW - Adsorption
KW - Aquatic moss
KW - Arsenic removal
KW - Arsenic speciation
KW - Arsenic uptake
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180419
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171120
STAT- In-Process
DOCNO- medline/29157972

19 - TOXLINE
TI - Arsenic hyperaccumulation and speciation in the edible ink stain bolete
(Cyanoboletus pulverulentus).
AU - Braeuer S
AD - University of Graz, Institute of Chemistry, Universit�tsplatz 1, 8010 Graz,
Austria.
AU - Goessler W
AD - University of Graz, Institute of Chemistry, Universit�tsplatz 1, 8010 Graz,
Austria.
AU - Kamen�k J
AD - Nuclear Physics Institute, The Czech Academy of Sciences, Hlavn� 130, 25068
Husinec-&#344;e&#382;, Czech Republic.
AU - Konvalinkov� T
AD - Institute of Microbiology, The Czech Academy of Sciences, V�de&#328;sk� 1083,
14220 Prague 4, Czech Republic.
AU - &#381;igov� A
AD - Institute of Geology, The Czech Academy of Sciences, Rozvojov� 269, 16500
Prague 6, Czech Republic.
AU - Borovi&#269;ka J
AD - Nuclear Physics Institute, The Czech Academy of Sciences, Hlavn� 130, 25068
Husinec-&#344;e&#382;, Czech Republic; Institute of Geology, The Czech Academy of
Sciences, Rozvojov� 269, 16500 Prague 6, Czech Republic. Electronic address:
bore.bor@gmail.com.
SO - Food Chem. 2018, Mar 01; 242:225-231. [Food chemistry]
AB - The edible ink stain bolete (Cyanoboletus pulverulentus) was found to
hyperaccumulate arsenic. We analyzed 39 individual collections determined
as C. pulverulentus, mostly from the Czech Republic. According to our
results, concentrations of arsenic in C. pulverulentus fruit-bodies may
reach 1300mgkg-1 dry weight. In most collections, data for total and
bioavailable arsenic in underlying soils were collected but no significant
correlation between the soil arsenic content and arsenic concentrations in
the associated fruit-bodies was found. Within the fruit-bodies, we found
the majority of arsenic accumulated in the hymenium. Besides occasional
traces of methylarsonic acid (MA), the arsenic speciation in all mushroom
samples consisted solely of dimethylarsinic acid (DMA) and no inorganic
arsenic was detected. Because of the carcinogenic potential of DMA, C.
pulverulentus should not be recommended as an edible mushroom and its
consumption should be restricted.
KW - Dimethylarsinic acid
KW - Edible mushrooms
KW - HPLC-ICPMS
KW - Health risk
KW - Soil
LA - eng
IS - 0308-8146 (Print)
PT - Journal Article
TA - Food Chem
YR - 2018
DATE- 20171017
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food chemistry
EDAT- 20170908
STAT- In-Process
DOCNO- medline/29037683

20 - TOXLINE
TI - Fertility in male rats: Disentangling adverse effects of arsenic
compounds.
AU - Lima GDA
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil.
AU - Sertorio MN
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil.
AU - Souza ACF
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil.
AU - Menezes TP
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil.
AU - Mouro VGS
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil.
AU - Gon�alves NM
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil.
AU - Oliveira JM
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil.
AU - Henry M
AD - Department of Veterinary Clinic and Surgery, Veterinary School, Federal
University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, 31270-901, Brazil.
AU - Machado-Neves M
AD - Department of General Biology, Federal University of Vi�osa (UFV), Vi�osa,
Minas Gerais, 36570-900, Brazil. Electronic address: mariana.mneves@ufv.br.
SO - Reprod Toxicol. 2018, Jun; 78:130-140. [Reproductive toxicology (Elmsford,
N.Y.)]
AB - Arsenic impairs male reproductive functions. However, it is not clear
whether different arsenic compounds similarly affect fertility. In this
study, we compared the impact of sodium arsenite and arsenate on sperm
quality and fertility. After 56&#8239;d exposure, male Wistar rats were
mated and pregnant females were evaluated by fertility indexes. Clearly,
exposure to 10&#8239;mg/L arsenite reduced daily sperm production via H2O2
overproduction and germ cells loss. Animals from this group also showed a
decrease in epididymal sperm counts and percentage of sperm with intact
membranes. Moreover, they presented low fertility potential and high
preimplantation loss. In contrast, 10&#8239;mg/L arsenate caused oxidative
stress in testis, mineral imbalance in epididymis, and sperm membranes
damage, with no effects on fertility. Both arsenic compounds at
0.01&#8239;mg/L altered reproductive parameters. We concluded that
arsenite is more harmful than arsenate to sperm quality and male
fertility, with negative influences in early pregnancy.
KW - Arsenate
KW - Arsenite
KW - Fertility potential
KW - Reproductive toxicity
KW - Sperm viability
KW - Trace elements imbalance
LA - eng
IS - 1873-1708 (Electronic)
PT - Journal Article
TA - Reprod Toxicol
YR - 2018
DATE- 20180601
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Reproductive toxicology (Elmsford, N.Y.)
EDAT- 20180424
STAT- In-Data-Review
DOCNO- medline/29702248

21 - TOXLINE
TI - Chronic arsenic intoxication diagnostic score (CAsIDS).
AU - Dani SU
AD - PizolCare Praxis Wartau, Tr�bbach, Switzerland.
AU - Walter GF
AD - International Neuroscience Institute, Hannover, Germany.
SO - J Appl Toxicol. 2018, Jan; 38(1):122-144. [Journal of applied toxicology :
JAT]
AB - Arsenic and its compounds are well-established, potent, environmentally
widespread and persistent toxicants with metabolic, genotoxic, mutagenic,
teratogenic, epigenetic and carcinogenic effects. Arsenic occurs naturally
in the Earth's crust, but anthropogenic arsenic emissions have surmounted
the emissions from important natural sources such as volcanism. Inorganic
arsenicals exhibit acute and chronic toxicities in virtually all cell
types and tissues, and hence arsenic intoxication affects multiple
systems. Whereas acute arsenic intoxication is rare and relatively easy to
diagnose, chronic arsenic intoxication (CAsI) is common but goes often
misdiagnosed. Based on a review of the literature as well as our own
clinical experience, we propose a chronic arsenic intoxication diagnostic
score (CAsIDS). A distinctive feature of CAsIDS is the use of bone arsenic
load as an essential criterion for the individual risk assessment of
chronic arsenic intoxication, combined with a systemic clinical
assessment. We present clinical examples where CAsIDS is applied for the
diagnosis of CAsI, review the main topics of the toxicity of arsenic in
different cell and organ systems and discuss the therapy and prevention of
disease caused or aggravated by chronic arsenic intoxication. CAsIDS can
help physicians establish the diagnosis of CAsI and associated conditions.
KW - CAsIDS
KW - arsenic
KW - bone
KW - chronic
KW - intoxication
KW - risk assessment
LA - eng
IS - 1099-1263 (Electronic)
PT - Journal Article
PT - Review
TA - J Appl Toxicol
YR - 2018
DATE- 20171124
CI - Copyright &copy; 2017 John Wiley &amp; Sons, Ltd.
CITO- NLM
CS - England
FJT - Journal of applied toxicology : JAT
EDAT- 20170831
STAT- In-Process
DOCNO- medline/28857213

22 - TOXLINE
TI - Arsenic exposure, diabetes-related genes and diabetes prevalence in a
general population from Spain.
AU - Grau-Perez M
AD - Area of Cardiometabolic and Renal Risk, Biomedical Research Institute
Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Statistics
and Operational Research, University of Valencia, Valencia, Spain; Department of
Environmental Health and Engineering, Columbia University Mailman School of Public
Health, New York, NY, USA.
AU - Navas-Acien A
AD - Department of Environmental Health and Engineering, Columbia University
Mailman School of Public Health, New York, NY, USA; Department of Environmental
Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD,
USA.
AU - Galan-Chilet I
AD - Genomic and Genetic Diagnosis Unit, Biomedical Research Institute Hospital
Clinic of Valencia (INCLIVA), Valencia, Spain.
AU - Briongos-Figuero LS
AD - Department of Internal Medicine, University Hospital Rio Hortega, Valladolid,
Spain.
AU - Morchon-Simon D
AD - Department of Internal Medicine, University Hospital Rio Hortega, Valladolid,
Spain.
AU - Bermudez JD
AD - Department of Statistics and Operational Research, University of Valencia,
Valencia, Spain.
AU - Crainiceanu CM
AD - Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health,
Baltimore, MD, USA.
AU - de Marco G
AD - Genomic and Genetic Diagnosis Unit, Biomedical Research Institute Hospital
Clinic of Valencia (INCLIVA), Valencia, Spain.
AU - Rentero-Garrido P
AD - Genomic and Genetic Diagnosis Unit, Biomedical Research Institute Hospital
Clinic of Valencia (INCLIVA), Valencia, Spain.
AU - Garcia-Barrera T
AD - Department of Chemistry, University of Huelva, Huelva, Spain.
AU - Gomez-Ariza JL
AD - Department of Chemistry, University of Huelva, Huelva, Spain.
AU - Casasnovas JA
AD - Unidad de Investigaci�n en Prevenci�n Cardiovascular, Instituto de
Investigaci�n Sanitaria de Arag�n, CIBER Cardiovascular (CIBERCV), Zaragoza, Spain.
AU - Martin-Escudero JC
AD - Department of Internal Medicine, University Hospital Rio Hortega, Valladolid,
Spain.
AU - Redon J
AD - Area of Cardiometabolic and Renal Risk, Biomedical Research Institute
Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; CIBER Physiopathology of
Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Minister of
Health, Madrid, Spain; Department of Internal Medicine, Hospital Cl�nico de
Valencia, Valencia, Spain.
AU - Chaves FJ
AD - Genomic and Genetic Diagnosis Unit, Biomedical Research Institute Hospital
Clinic of Valencia (INCLIVA), Valencia, Spain; CIBER of Diabetes and Associated
Metabolic Diseases (CIBERDEM), Barcelona, Spain. Electronic address:
felipe.chaves@uv.es.
AU - Tellez-Plaza M
AD - Area of Cardiometabolic and Renal Risk, Biomedical Research Institute
Hospital Clinic of Valencia (INCLIVA), Valencia, Spain; Department of Environmental
Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD,
USA.
SO - Environ Pollut. 2018, Apr; 235:948-955. [Environmental pollution (Barking,
Essex : 1987)]
AB - Inorganic arsenic exposure may be associated with diabetes, but the
evidence at low-moderate levels is not sufficient. Polymorphisms in
diabetes-related genes have been involved in diabetes risk. We evaluated
the association of inorganic arsenic exposure on diabetes in the Hortega
Study, a representative sample of a general population from Valladolid,
Spain. Total urine arsenic was measured in 1451 adults. Urine arsenic
speciation was available in 295 randomly selected participants. To account
for the confounding introduced by non-toxic seafood arsenicals, we
designed a multiple imputation model to predict the missing arsenobetaine
levels. The prevalence of diabetes was 8.3%. The geometric mean of total
arsenic was 66.0&#8239;&mu;g/g. The adjusted odds ratios (95% confidence
interval) for diabetes comparing the highest with the lowest tertile of
total arsenic were 1.76 (1.01, 3.09) and 2.14 (1.47, 3.11) before and
after arsenobetaine adjustment, respectively. Polymorphisms in several
genes including IL8RA, TXN, NR3C2, COX5A and GCLC showed suggestive
differential associations of urine total arsenic with diabetes. The
findings support the role of arsenic on diabetes and the importance of
controlling for seafood arsenicals in populations with high seafood
intake. Suggestive arsenic-gene interactions require confirmation in
larger studies.
KW - Arsenic
KW - Arsenic species
KW - Diabetes
KW - Gene-environment interaction
KW - Multiple imputation
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180512
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180221
STAT- In-Process
DOCNO- medline/29751399

23 - TOXLINE
TI - Dilution of rice with other gluten free grains to lower inorganic arsenic
in foods for young children in response to European Union regulations
provides impetus to setting stricter standards.
AU - Carey M
AD - Institute for Global Food Security, Queen's University Belfast, Belfast,
Northern Ireland.
AU - Donaldson E
AD - Institute for Global Food Security, Queen's University Belfast, Belfast,
Northern Ireland.
AU - Signes-Pastor AJ
AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College,
Lebanon, New Hampshire, United States of America.
AU - Meharg AA
AD - Institute for Global Food Security, Queen's University Belfast, Belfast,
Northern Ireland.
SO - PLoS One. 2018; 13(3):e0194700. [PloS one]
AB - There has been an increasing realisation that young infants are exposed to
elevated concentrations of the carcinogen inorganic arsenic, relative to
adults. This is because many infant food products are rice based, and rice
is ~10-fold elevated in inorganic arsenic compared to most other foods.
The European Commission (EC) has acted on this concern setting stricter
standards for infants, 100 &mu;g of inorganic arsenic per kg of food (100
&mu;g/kg), as compared to adults (200 &mu;g/kg), for rice based foods, a
law that was brought into place in 1st January 2016. Here we investigate
how this law has impacted on inorganic arsenic in baby food products in
the UK market, and compare the findings to previous baby food surveys
taken before and just after the law came into place. We find that for a
wide range of UK infant products that the new regulations are being
adhered to, with all samples surveyed, being under 100 &mu;g/kg inorganic
arsenic. The prevalence of pure rice products had decreased in the UK, and
there appears to be careful sourcing of the rice used in these products to
ensure conformity with regulations. There has been an increased presence
of mixed cereal products, with rice and maize as the main ingredient,
appearing on the UK market, with varying rice contents for infant
porridges, cakes and mueslis, with the latter being a relatively
innovative product for infant foods. There was a highly significant
correlation (P < 0.0001) between rice content and inorganic arsenic
concentration across all infant foods. When UK infant rice cakes,
breakfast cereals and porridges were compare to their general, i.e. not
labelled specifically for being for infant consumption, equivalent it was
found that the adult foods generally exceeded the 100 &mu;g/kg inorganic
arsenic standard for infant foods. Thus, infants should not be given rice
products not specifically labelled as being for them if a lower inorganic
arsenic diet is to be maintained.
LA - eng
IS - 1932-6203 (Electronic)
PT - Journal Article
TA - PLoS One
YR - 2018
DATE- 20180329
CITO- NLM
CS - United States
FJT - PloS one
EDAT- 20180316
STAT- In-Data-Review
CM - Cites: Food Chem Toxicol. 2015 Oct;84:169-80 (medline /26327433)
CM - Cites: Sci Rep. 2017 Oct 30;7(1):14312 (medline /29085002)
CM - Cites: Environ Pollut. 2008 Apr;152(3):746-9 (medline /18339463)
CM - Cites: J Food Sci. 2012 Jan;77(1):T15-9 (medline /22181972)
CM - Cites: Pure Appl Chem. 2012;84(2):215-223 (medline /22701232)
CM -Cites: PLoS One. 2015 Jul 22;10(7):e0131608 (medline /26200355)
CM -Cites: Environ Pollut. 2012 Apr;163:77-83 (medline /22325434)
CM -Cites: Food Chem. 2016 Jan 15;191:128-34 (medline /26258711)
CM -Cites: Environ Sci Technol. 2009 Mar 1;43(5):1612-7 (medline /19350943)
CM -Cites: Food Chem. 2018 Jan 15;239:132-140 (medline /28873550)
CM -Cites: Environ Sci Technol. 2007 Oct 1;41(19):6854-9 (medline /17969706)
CM -Cites: Environ Res. 2016 May;147:537-55 (medline /26891939)
CM -Cites: Environ Sci Technol. 2010 Jun 15;44(12):4395-9 (medline /20465302)
CM -Cites: Annu Rev Nutr. 2009;29:381-99 (medline /19575603)
CM -Cites: PLoS One. 2017 May 4;12 (5):e0176923 (medline /28472079)
CM -Cites: Cortex. 2016 Jan;74:370-82 (medline /25682472)
CM -Cites: Toxicol Appl Pharmacol. 2013 Oct 15;272(2):384-90 (medline
/23859881)
CM - Cites: Mol Plant Pathol. 2004 Nov 1;5(6):515-25 (medline /20565626)
CM - Cites: Food Addit Contam Part B Surveill. 2010;3(4):275-88 (medline
/24779628)
CM - Cites: Food Chem. 2014 May 1;150:199-205 (medline /24360440)
CM - Cites: Environ Health Perspect. 2015 May;123(5):500-6 (medline /25707031)
DOCNO- medline/29547635

24 - TOXLINE
TI - Arsenic Exposure from Drinking Water and Urinary Metabolomics:
Associations and Long-Term Reproducibility in Bangladesh Adults.
AU - Wu F
AD - Department of Environmental Medicine, New York University School of
Medicine , New York, New York, USA.
AU - Chi L
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
AU - Ru H
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
AU - Parvez F
AD - Department of Environmental Health Sciences, Mailman School of Public Health,
Columbia University, New York, New York, USA.
AU - Slavkovich V
AD - Department of Environmental Health Sciences, Mailman School of Public Health,
Columbia University, New York, New York, USA.
AU - Eunus M
AD - U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
AU - Ahmed A
AD - U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
AU - Islam T
AD - U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
AU - Rakibuz-Zaman M
AD - U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
AU - Hasan R
AD - U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
AU - Sarwar G
AD - U-Chicago Research Bangladesh, Ltd., Dhaka, Bangladesh.
AU - Graziano JH
AD - Department of Environmental Health Sciences, Mailman School of Public Health,
Columbia University, New York, New York, USA.
AU - Ahsan H
AD - Department of Health Studies, Center for Cancer Epidemiology and Prevention,
University of Chicago, Chicago, Illinois, USA.
AU - Lu K
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
AU - Chen Y
AD - Department of Environmental Medicine, New York University School of
Medicine , New York, New York, USA.
SO - Environ Health Perspect. 2018, Jan 12; 126(1):017005. [Environmental
health perspectives]
AB - BACKGROUND: Chronic exposure to inorganic arsenic from drinking water has
been associated with a host of cancer and noncancer diseases. The
application of metabolomics in epidemiologic studies may allow researchers
to identify biomarkers associated with arsenic exposure and its health
effects.
AB - OBJECTIVE: Our goal was to evaluate the long-term reproducibility of
urinary metabolites and associations between reproducible metabolites and
arsenic exposure.
AB - METHODS: We studied samples and data from 112 nonsmoking participants (58
men and 54 women) who were free of any major chronic diseases and who were
enrolled in the Health Effects of Arsenic Longitudinal Study (HEALS), a
large prospective cohort study in Bangladesh. Using a global gas
chromatography-mass spectrometry platform, we measured metabolites in
their urine samples, which were collected at baseline and again 2 y apart,
and estimated intraclass correlation coefficients (ICCs). Linear
regression was used to assess the association between arsenic exposure at
baseline and metabolite levels in baseline urine samples.
AB - RESULTS: We identified 2,519 molecular features that were present in all
224 urine samples from the 112 participants, of which 301 had an ICC of
&ge;0.60. Of the 301 molecular features, water arsenic was significantly
related to 31 molecular features and urinary arsenic was significantly
related to 74 molecular features after adjusting for multiple comparisons.
Six metabolites with a confirmed identity were identified from the 82
molecular features that were significantly associated with either water
arsenic or urinary arsenic after adjustment for multiple comparisons.
AB - CONCLUSIONS: Our study identified urinary metabolites with long-term
reproducibility that were associated with arsenic exposure. The data
established the feasibility of using metabolomics in future larger
studies. https://doi.org/10.1289/EHP1992.
LA - eng
IS - 1552-9924 (Electronic)
PT - Journal Article
TA - Environ Health Perspect
YR - 2018
DATE- 20180413
CITO- NLM
CS - United States
FJT - Environmental health perspectives
EDAT- 20180112
STAT- In-Data-Review
DOCNO- medline/29329102

25 - TOXLINE
TI - Arsenite increases Cyclin D1 expression through coordinated regulation of
the Ca2+/NFAT2 and NF-&kappa;B pathways via ERK/MAPK in a human
uroepithelial cell line.
AU - Liu J
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
Liaoning Province 110122, P. R. China. shxi@cmu.edu.cn.
AU - Jin P
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
Liaoning Province 110122, P. R. China. shxi@cmu.edu.cn.
AU - Lin X
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
Liaoning Province 110122, P. R. China. shxi@cmu.edu.cn.
AU - Zhou Q
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
Liaoning Province 110122, P. R. China. shxi@cmu.edu.cn.
AU - Wang F
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
Liaoning Province 110122, P. R. China. shxi@cmu.edu.cn.
AU - Liu S
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
Liaoning Province 110122, P. R. China. shxi@cmu.edu.cn.
AU - Xi S
AD - Department of Environmental and Occupational Health, Liaoning Provincial Key
Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health,
China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang,
Liaoning Province 110122, P. R. China. shxi@cmu.edu.cn.
SO - Metallomics. 2018, Mar 01; 10(3):486-495. [Metallomics : integrated
biometal science]
AB - To understand the direct link between Cyclin D1, and nuclear factor of
activated T cells 2 (NFAT2) and nuclear factor (NF)-&kappa;B in
arsenic-treated bladder cells, as well as the association between MAPK and
NFAT signaling, we determined whether or not the Ca2+/NFAT pathway is
activated in an arsenic-treated normal urothelial cell line and determined
the roles of NFAT and NF-&kappa;B signals in the regulation of Cyclin D1
expression. The SV-40 immortalized human uroepithelial cell line,
SV-HUC-1, was treated with NaAsO2 for 24 h (0, 1, 2, 4, 8, and 10 &mu;M)
and 10, 20, 30, and 40 weeks (0 and 0.5 &mu;M). We found that arsenite
increased the intracellular Ca2+ levels and induced NFAT2 nuclear
translocation after treatment for 24 h. The level of NFAT2 mRNA and
expression of total protein and nuclear protein were increased after
long-term treatment with 0.5 &mu;M arsenite for 30 and 40 weeks compared
to the cells treated for 24 h. In addition, NF-&kappa;B p50 and p65
nuclear protein expression increased significantly in cells treated with
2-8 &mu;M arsenite for 24 h, which was consistent with NFAT2 nuclear
expression. Furthermore, an ERK inhibitor (U0126) significantly reduced
the expression of NFAT2 nuclear protein, and an ERK and JNK inhibitor
decreased the levels of p65 and p50 nuclear protein. Cyclin D1 is known as
a proto-oncogene and the level of this protein was increased in SV-HUC-1
cells treated with arsenite for 24 h and long-term. An NFAT inhibitor
(CsA) and NF-&kappa;B inhibitor (PDTC) all markedly reduced Cyclin D1
protein expression. Treatment with U0126 also significantly decreased
Cyclin D1 protein expression while JNK and p38 inhibitors did not
attenuate the arsenite-associated increase in Cyclin D1 protein
expression. The results suggest that regulation of Cyclin D1 protein
expression by arsenite in SV-HUC-1 cells is dependent on ERK/NFAT2 and
ERK/NF-&kappa;B, but is not dependent on JNK or p38.
LA - eng
IS - 1756-591X (Electronic)
PT - Journal Article
TA - Metallomics
YR - 2018
DATE- 20180323
CITO- NLM
CS - England
FJT - Metallomics : integrated biometal science
EDAT- 20180312
STAT- In-Data-Review
DOCNO- medline/29528074

26 - TOXLINE
TI - Characterising microbial reduction of arsenate sorbed to ferrihydrite and
its concurrence with iron reduction.
AU - Huang JH
AD - Environmental Geosciences, University of Basel, CH-4056, Basel, Switzerland.
Electronic address: jen-how.huang@unibas.ch.
SO - Chemosphere. 2018, Mar; 194:49-56. [Chemosphere]
AB - A series of model anoxic incubations were performed to understand the
concurrence between arsenate and ferrihydrite reduction by Shewanella
putrefaciens strain CN-32 at different concentrations of arsenate,
ferrihydrite and lactate, and with given &Delta;Grxn for arsenate and
ferrihydrite reduction in non-growth conditions. The reduction kinetics of
arsenate sorbed to ferrihydrite is predominately controlled by the
availability of dissolved arsenate, which is measured by the integral of
dissolved arsenate concentrations against incubation time and shown to
correlate with the first order rate constants. High lactate concentrations
slightly slowed down the rate of arsenate reduction due to the competition
with arsenate for microbial contact. Under all experimental conditions,
simultaneous arsenate and ferrihydrite reduction occurred following
addition of S. putrefaciens inoculums and suggested no apparent
competition between these two enzymatic reductions. Ferrous ions released
from iron reduction might retard microbial arsenate reduction at high
arsenate and ferrihydrite concentrations due to formation of ferrous
arsenate. At high arsenate to ferrihydrite ratios, reductive dissolution
of ferrihydrite shifted arsenate from sorption to dissolution and hence
accelerated arsenate reduction. The interaction between microbial arsenate
and ferrihydrite reduction did not correlate with &Delta;Grxn, but instead
was governed by other factors such as geochemical and microbial
parameters.
KW - Arsenate reduction
KW - Ferrihydrite
KW - Kinetics
KW - Shewanella
RN - 87PZU03K0K
RN - E1UOL152H7
RN - N7CIZ75ZPN
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180416
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171121
STAT- MEDLINE
DOCNO- medline/29197249

27 - TOXLINE
TI - Metabolism and disposition of arsenic species after repeated oral dosing
with sodium arsenite in drinking water. II. Measurements in pregnant and
fetal CD-1 mice.
AU - Twaddle NC
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
AU - Vanlandingham M
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
AU - Beland FA
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
AU - Doerge DR
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States.
Electronic address: daniel.doerge@fda.hhs.gov.
SO - Food Chem Toxicol. 2018, May; 115:178-184. [Food and chemical toxicology :
an international journal published for the British Industrial Biological
Research Association]
AB - Arsenic is ubiquitous in the earth's crust, and human diseases are linked
with exposures that are similar to dietary intake estimates. Metabolic
methylation of inorganic arsenic facilitates excretion of pentavalent
metabolites and decreases acute toxicity; however, tissue binding of
trivalent arsenic intermediates is evidence for concomitant metabolic
activation. Pregnant and fetal CD-1 mice comprise a key animal model for
arsenic carcinogenesis since adult-only exposures have minimal effects.
This study evaluated inorganic arsenic and its metabolites in pentavalent
and trivalent states in blood and tissues from maternal and fetal CD-1
mice after repeated administration of arsenite through drinking water.
After 8 days of exposure, DMA species were ubiquitous in dams and fetuses.
Despite the presence of MMAIII in dams, none was observed in any fetal
sample. This difference may be important in assessing fetal susceptibility
to arsenic toxicity because MMA production has been linked with human
disease. Binding of DMAIII in fetal tissues provided evidence for
metabolic activation, although the role for such binding in arsenic
toxicity is unclear. This study provides links between administered dose,
metabolism, and internal exposures from a key animal model of arsenic
toxicity to better understand risks from human exposure to environmental
arsenic.
KW - Arsenic
KW - Carcinogenesis
KW - Fetus
KW - Metabolism
KW - Pregnancy
KW - Toxicokinetics
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180504
CI - Copyright &copy; 2018. Published by Elsevier Ltd.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180310
STAT- In-Process
DOCNO- medline/29530638

28 - TOXLINE
TI - Microbe mediated arsenic release from iron minerals and arsenic
methylation in rhizosphere controls arsenic fate in soil-rice system after
straw incorporation.
AU - Yang YP
AD - State Key Lab of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's
Republic of China; University of Chinese Academy of Sciences, Beijing 100049,
People's Republic of China.
AU - Zhang HM
AD - Jiaxing Academy of Agricultural Sciences, Xiuzhou District, Jiaxing 314016,
People's Republic of China.
AU - Yuan HY
AD - State Key Lab of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's
Republic of China; University of Chinese Academy of Sciences, Beijing 100049,
People's Republic of China.
AU - Duan GL
AD - State Key Lab of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's
Republic of China; University of Chinese Academy of Sciences, Beijing 100049,
People's Republic of China. Electronic address: duangl@rcees.ac.cn.
AU - Jin DC
AD - State Key Lab of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's
Republic of China.
AU - Zhao FJ
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing
210095, People's Republic of China.
AU - Zhu YG
AD - State Key Lab of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's
Republic of China; University of Chinese Academy of Sciences, Beijing 100049,
People's Republic of China; Key Laboratory of Urban Environment and Health,
Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021,
People's Republic of China.
SO - Environ Pollut. 2018, May; 236:598-608. [Environmental pollution (Barking,
Essex : 1987)]
AB - Arsenic (As) contamination is a global problem. Straw incorporation is
widely performed in As contaminated paddy fields. To understand how straw
and straw biochar incorporation affect As transformation and translocation
in the soil-microbe-rice system, a pot experiment was carried out with
different dosages of rice straw and straw biochar application. Results
showed that both straw biochar and straw application significantly
increased As mobility. Straw biochar mobilized As mainly through
increasing soil pH and DOM content. Straw incorporation mainly through
enhancing As release from iron (Fe) minerals and arsenate (As(V))
reduction to arsenite (As(III)). Straw biochar didn't significantly affect
As methylation, while straw incorporation significantly enhanced As
methylation, elevated dimethylarsenate (DMA) concentration in soil
porewater and increased As volatilization. Straw biochar didn't
significantly change total As accumulation in rice grains, but decreased
As(III) accumulation by silicon (Si) inhibition. Straw incorporation
significantly increased DMA, but decreased As(III) concentration in rice
grains. After biochar application, dissolved As was significantly
positively correlated with the abundance of Bacillus, indicating that
Bacillus might be involved in As release, and As(III) concentration in
polished grains was negatively correlated with Si concentration. The
significant positive correlation between dissolved As with Fe and the
abundance of iron-reducing bacteria suggested the coupling of As and Fe
reduction mediated by iron-reducing bacteria. The significant positive
correlation between DMA in rice grains and the abundance of methanogenic
bacteria indicated that methanogenic bacteria could be involved in As
methylation after straw application. The results of this study would
advance the understanding how rice straw incorporation affects As fate in
soil-microbe-rice system, and provide some guidance to straw incorporation
in As contaminated paddy soil. This study also revealed a wealth of
microorganisms in the soil environment that dominate As mobility and
transformation after straw incorporation.
KW - Arsenic methylation
KW - Arsenic mobility
KW - Rice (Oryza sativa L.)
KW - Straw biochar
KW - Straw incorporation
RN - 16291-96-6
RN - AJ2HL7EU8K
RN - E1UOL152H7
RN - N5509X556J
RN - N712M78A8G
RN - N7CIZ75ZPN
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180608
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
STAT- MEDLINE
DOCNO- medline/29433100

29 - TOXLINE
TI - Arsenic species in rice and rice-based products consumed by toddlers in
Switzerland.
AU - Guillod-Magnin R
AD - a Division of Risk Assessment , Federal Food Safety and Veterinary Office
(FSVO) , Berne , Switzerland.
AU - Br�schweiler BJ
AD - a Division of Risk Assessment , Federal Food Safety and Veterinary Office
(FSVO) , Berne , Switzerland.
AU - Aubert R
AD - a Division of Risk Assessment , Federal Food Safety and Veterinary Office
(FSVO) , Berne , Switzerland.
AU - Haldimann M
AD - a Division of Risk Assessment , Federal Food Safety and Veterinary Office
(FSVO) , Berne , Switzerland.
SO - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018, Feb
27:1-15. [Food additives & contaminants. Part A, Chemistry, analysis,
control, exposure & risk assessment]
AB - Inorganic arsenic (iAs) is a contaminant present in food, especially in
rice and rice-based products. Toxicity of arsenic compounds (As) depends
on species and oxidative state. iAs species, such as arsenite (As(III))
and arsenate (As(V)), are more bioactive and toxic than organic arsenic
species, like methylarsonic acid (MMA(V)) and dimethylarsinic acid
(DMA(V)) or arsenosugars and arsenobetaine. An ion
chromatography-inductively coupled-plasma-mass spectroscopy method was
developed to separate the four following arsenic anions: As(III), As(V),
MMA(V) and DMA(V). Sample preparation was done in mild acidic conditions
to ensure species preservation. The predominant arsenic species found in
rice and rice-based products, except for rice drinks, was As(III), with
60-80% of the total As content, followed by DMA(V) and As(V). MMA(V) was
measured only at low levels ( < 3%). Analyses of rice products
(N = 105) intended for toddlers, including special products
destined for infants and toddlers, such as dry form baby foods
(N = 12) or ready-to-use form (N = 9), were done. It
was found in this study that there is little or no margin of exposure.
Risk assessment, using the occurrence data and indicated intake scenarios
compared to reference BMDLs as established by EFSA, demonstrated toddlers
with a high consumption of rice based cereals and rice drinks are at risk
of high iAs exposure, for which a potential health risk cannot be
excluded.
KW - IC-ICP-MS
KW - arsenic speciation
KW - exposure assessment
KW - rice-based baby foods
KW - risk assessment
LA - eng
IS - 1944-0057 (Electronic)
PT - Journal Article
TA - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
YR - 2018
DATE- 20180227
CITO- NLM
CS - England
FJT - Food additives &amp; contaminants. Part A, Chemistry, analysis, control,
exposure &amp; risk assessment
EDAT- 20180227
STAT- Publisher
DOCNO- medline/29448893

30 - TOXLINE
TI - Purification of arsenic-contaminated water with K-jarosite filters.
AU - Hott RC
AD - Instituto de Ci�ncia, Engenharia e Tecnologia (ICET), Universidade Federal
dos Vales do Jequitinhonha e Mucuri (UFVJM), Te�filo Otoni, Minas Gerais, 39803-
371, Brazil.
AU - Maia LFO
AD - Instituto de Ci�ncia, Engenharia e Tecnologia (ICET), Universidade Federal
dos Vales do Jequitinhonha e Mucuri (UFVJM), Te�filo Otoni, Minas Gerais, 39803-
371, Brazil.
AU - Santos MS
AD - Instituto de Ci�ncia, Engenharia e Tecnologia (ICET), Universidade Federal
dos Vales do Jequitinhonha e Mucuri (UFVJM), Te�filo Otoni, Minas Gerais, 39803-
371, Brazil.
AU - Faria MC
AD - Instituto de Ci�ncia, Engenharia e Tecnologia (ICET), Universidade Federal
dos Vales do Jequitinhonha e Mucuri (UFVJM), Te�filo Otoni, Minas Gerais, 39803-
371, Brazil.
AU - Oliveira LCA
AD - Departamento de Qu�mica, ICEx, Universidade Federal de Minas Gerais, Belo
Horizonte, Minas Gerais, 31270-901, Brazil.
AU - Pereira MC
AD - Instituto de Ci�ncia, Engenharia e Tecnologia (ICET), Universidade Federal
dos Vales do Jequitinhonha e Mucuri (UFVJM), Te�filo Otoni, Minas Gerais, 39803-
371, Brazil.
AU - Bomfeti CA
AD - Instituto de Ci�ncia, Engenharia e Tecnologia (ICET), Universidade Federal
dos Vales do Jequitinhonha e Mucuri (UFVJM), Te�filo Otoni, Minas Gerais, 39803-
371, Brazil.
AU - Rodrigues JL
AD - Instituto de Ci�ncia, Engenharia e Tecnologia (ICET), Universidade Federal
dos Vales do Jequitinhonha e Mucuri (UFVJM), Te�filo Otoni, Minas Gerais, 39803-
371, Brazil. jairo.rodrigues@ufvjm.edu.br.
SO - Environ Sci Pollut Res Int. 2018, May; 25(14):13857-13867. [Environmental
science and pollution research international]
AB - The high toxicity and potential arsenic accumulation in several
environments have encouraged the development of technologies for its
removal from contaminated waters. However, the arsenic released into
aquatic environment comes mainly from extremely acidic mining effluents,
making harder to find stable adsorbents to be used in these conditions. In
this work, K-jarosite particles were synthesized as a stable adsorbent in
acidic medium for eliminating arsenic from contaminated water. The
adsorption capacities of K-jarosite for As3+, As5+, and monomethylarsonic
acid were 9.45, 12.36, and 8.21 mg g-1, respectively. Most
arsenic in water was adsorbed within the first 10 min, suggesting the
fast arsenic adsorption kinetics of K-jarosite particles. Because of that,
a K-jarosite filter was constructed for purifying water at a constant
flow. The K-jarosite filter was highly efficient to treat
arsenic-contaminated water from a Brazilian river, reducing the
concentration of arsenic in water to near zero. These data suggest the
K-jarosite filter can be used as a low-cost technology for purifying
arsenic-contaminated water in acidic medium.
KW - Adsorption
KW - Arsenate
KW - Arsenic
KW - Arsenite
KW - Filter
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180525
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180306
STAT- In-Process
CM - Cites: J Hazard Mater. 2009 Nov 15;171(1-3):965-72 (medline /19628332)
CM - Cites: J Environ Manage. 2017 Jan 15;186(Pt 2):261-267 (medline /27480915)
CM - Cites: J Environ Health Sci Eng. 2014 Mar 06;12(1):58 (medline /24602339)
CM - Cites: J Environ Sci (China). 2016 Nov;49:86-96 (medline /28007183)
CM - Cites: Environ Sci Pollut Res Int. 2014 Mar;21(5):3218-29 (medline
/24203255)
CM - Cites: J Hazard Mater. 2016 Apr 5;306:124-132 (medline /26705889)
CM - Cites: Int J Environ Res Public Health. 2013 Apr 12;10(4):1527-46 (medline
/23583964)
CM - Cites: J Environ Sci (China). 2011;23(9):1544-50 (medline /22432292)
CM - Cites: Environ Sci Pollut Res Int. 2016 Nov;23 (21):21969-21979 (medline
/27539466)
CM - Cites: Environ Toxicol Pharmacol. 2016 Dec;48:214-224 (medline /27829199)
DOCNO- medline/29512010

31 - TOXLINE
TI - The effect of association between inefficient arsenic methylation capacity
and demographic characteristics on the risk of skin lesions.
AU - Rasheed H
AD - water@leeds, School of Geography, University of Leeds, Leeds LS2 s9JT, United
Kingdom. Electronic address: gyhj@leeds.ac.uk.
AU - Kay P
AD - water@leeds, School of Geography, University of Leeds, Leeds LS2 s9JT, United
Kingdom.
AU - Slack R
AD - water@leeds, School of Geography, University of Leeds, Leeds LS2 s9JT, United
Kingdom.
AU - Gong YY
AD - School of Food Science and Nutrition, University of Leeds, Leeds LS2 9JT,
United Kingdom.
SO - Toxicol Appl Pharmacol. 2018, Jan 15; 339:42-51. [Toxicology and applied
pharmacology]
AB - This study was conducted in rural Pakistan to assess the dose-response
relationship between skin lesions and arsenic exposure and their variation
by demographic characteristics. The study included 398 participants (66
participants with skin lesions and 332 without) residing in six previously
unstudied villages exposed to ground water arsenic in the range of < 1
to 3090&mu;gL-1. The skin lesions identification process involved
interview and physical examinations of participants followed by
confirmation by a physician according to UNICEF criteria. Urinary
inorganic arsenic (iAs), total arsenic (tAs), monomethylarsonic acid
(MMA), and dimethylarsinic acid (DMA) were analysed to determine
methylation capacity, methylation efficiency and the dose-response
relationship with skin lesions. Study participants with skin lesions were
found to be exposed to arsenic > 10&mu;gL-1 with a daily arsenic intake
of 3.23&plusmn;3.75mgday-1 from household ground water sources for an
exposure duration of 10-20years. The participants with skin lesions
compared to those without skin lesions showed higher levels of urinary iAs
(133.40&plusmn;242.48 vs. 44.24&plusmn;86.48&mu;gg-1Cr), MMA
(106.38&plusmn;135.04 vs. 35.43&plusmn;39.97&mu;gg-1Cr), MMA%
(15.26&plusmn;6.31 vs.12.11&plusmn;4.68) and lower levels of DMA%
(66.99&plusmn;13.59 vs. 73.39&plusmn;10.44) and secondary methylation
index (SMI) (0.81&plusmn;0.11 vs. 0.86&plusmn;0.07). Study participants
carrying a lower methylation capacity characterized by higher MMA% (OR
5.06, 95% CI: 2.09-12.27), lower DMA% (OR 0.64, 95% CI: 0.33-1.26),
primary methylation index (PMI) (OR 0.56, 95% CI: 0.28-1.12) and SMI (OR
0.43, 95% CI: 0.21-0.88) had a significantly higher risk of skin lesions
compared to their corresponding references after adjusting for occupation
categories. The findings confirmed that inefficient arsenic methylation
capacity was significantly associated with increased skin lesion risks and
the effect might be modified by labour intensive occupations.
KW - Arsenicosis
KW - Hyperpigmentation
KW - Keratosis
KW - Methylation capacity
KW - Monomethylarsonic acid (MMA)
KW - Skin lesions
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180108
CI - Crown Copyright &copy; 2017. Published by Elsevier Inc. All rights
reserved.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20171129
STAT- In-Data-Review
DOCNO- medline/29197518

32 - TOXLINE
TI - Inorganic arsenic exposure increased expression of Fas and Bax gene in
vivo and vitro.
AU - He Y
AD - School of Public Health, Kunming Medical University, China. Electronic
address: heyuefeng@kmmu.edu.cn.
AU - Zhang R
AD - School of Public Health, Kunming Medical University, China.
AU - Xiaoxiao S
AD - School of Public Health, Kunming Medical University, China.
AU - Li S
AD - School of Public Health, Kunming Medical University, China.
AU - Xinan W
AD - School of Public Health, Kunming Medical University, China.
AU - Huang D
AD - The Second People's Hospital of Yunnan Province, China. Electronic address:
Huangdahai2000@163.com.
SO - Gene. 2018, Jun 01. [Gene]
AB - Accumulating evidences have shown that apoptosis plays an important role
in mediating the therapeutic effects and toxicity of arsenic. Fas and Bax
genes are critical regulatory genes for apoptosis. In this study, we
investigated the association between levels of Fas and Bax expression and
the three arsenic species (inorganic arsenic (iAs), monomethylarsonic acid
(MMA) and dimethylarsinic acid (DMA)) in vivo and vitro. Three arsenic
species in urine were measured and levels of Fas and Bax expression were
examined by the quantitative real-time PCR (qPCR) for all subjects. We
found that Fas and Bax mRNA expression in the exposed group were
significantly higher than that in the control group. The levels of gene
expression were positively correlated with the concentrations of urinary
iAs, MMA and DMA in all subjects. Sodium arsenite induced Fas and Bax mRNA
expression, then MMA and DMA did not induce mRNA expression in MDA-MB-231
and XWLC-05 cells. The findings of the present study indicated that iAs,
MMA, and DMA had different effects on expression of Bax and Fas gene.
KW - Arsenic
KW - Bax
KW - DMA Fas
KW - MMA
LA - eng
IS - 1879-0038 (Electronic)
PT - Journal Article
TA - Gene
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2017. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
FJT - Gene
EDAT- 20180601
STAT- Publisher
DOCNO- medline/29864498

33 - TOXLINE
TI - A comparison of the determination and speciation of inorganic arsenic
using general HPLC methodology with UV, MS and MS/MS detection.
AU - Gilmartin G
AD - Analytical Development, Discovery &amp; Product Development, Teva Branded
Pharmaceutical Product R&amp;D, West Chester, PA, USA. Electronic address:
Gregory.Gilmartin@tevapharm.com.
AU - Gingrich D
AD - Analytical Development, Discovery &amp; Product Development, Teva Branded
Pharmaceutical Product R&amp;D, West Chester, PA, USA.
SO - J Chromatogr B Analyt Technol Biomed Life Sci. 2018, Apr 15; 1083:20-27.
[Journal of chromatography. B, Analytical technologies in the biomedical
and life sciences]
AB - The determination and speciation of arsenic in natural resources such as
drinking water and agricultural soils has been a growing concern in recent
years due to its many toxicological effects [1-3]. To speciate and
quantitate concentrations of < 1&#8239;ppm of arsenic, typically an ion
chromatograph (IC) interfaced to an inductively coupled plasma mass
spectrometer (ICP-MS) is employed [4-9]. This methodology may be very
robust and sensitive, but it is expensive and not as ubiquitous as high
performance liquid chromatography (HPLC) with ultraviolet (UV) absorbance
detection or electrospray ionization mass spectrometry (ESI-MS). Anion
exchange chromatography is a well-documented means of speciating arsenite
(As(III), As2O3) and arsenate (As(V), AsO4) using UV [10], conductivity
[11], or ESI-MS detection [12,13]. This paper demonstrates the utilization
of common liquid chromatographic instrumentation to speciate and
determines inorganic Arsenic compounds using UV or MS via selected ion
recording (SIR) or multiple reaction monitoring (MRM) detection. This
paper describes the analysis of arsenite and arsenate samples prepared
using both deionized and ground water. The limit of quantitation for the
techniques described in this paper for samples spiked in ground water were
454&#8239;ppb (As(III)) and 562&#8239;ppb (As(V)) for UV detection,
45.4&#8239;ppb (As(III)) and 56.2&#8239;ppb (As(V)) for SIR detection, and
4.54&#8239;ppb (As(III)) and 5.62&#8239;ppb (As(V)) for MRM detection.
KW - Arsenic determination
KW - Arsenic speciation
KW - MS and MS/MS detection
KW - UV detection
RN - N712M78A8G
LA - eng
IS - 1873-376X (Electronic)
PT - Comparative Study
PT - Journal Article
TA - J Chromatogr B Analyt Technol Biomed Life Sci
YR - 2018
DATE- 20180504
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Journal of chromatography. B, Analytical technologies in the biomedical
and life sciences
EDAT- 20180226
STAT- MEDLINE
DOCNO- medline/29518633

34 - TOXLINE
TI - Characterization of arsenite-oxidizing bacteria to decipher their role in
arsenic bioremediation.
AU - Biswas R
AD - a Department of Biotechnology and Medical Engineering , National Institute of
Technology Rourkela , Odisha.
AU - Sarkar A
AD - a Department of Biotechnology and Medical Engineering , National Institute of
Technology Rourkela , Odisha.
SO - Prep Biochem Biotechnol. 2018, Jun 11:1-8. [Preparative biochemistry &
biotechnology]
AB - High arsenic groundwater contamination causes serious health risks in many
developing countries, particularly in India and Bangladesh. The arsenic
fluxes in aquifers are primarily controlled by bacterial populations
through biogeochemical cycle. In this present study, two gram-positive
rod-shaped bacteria were isolated from shallow aquifers of Bhojpur
district in Bihar during the early winter season, able to withstand
arsenite (As3+) concentration upto 70&thinsp;mM and 1000&thinsp;mM of
arsenate (As5+) concentration. They showed high resistance to heavy metals
up to 30&thinsp;mM and utilized some complex sugars along with different
carbon sources. Growth at wide range of temperature, pH and salinity were
observed. Both these isolates showed high efficiency in converting As3+
into less toxic concentrations of As5+ respectively from arsenic enriched
culture media. Along with superior arsenic transformation and arsenic
resistance abilities, the isolates showed a wide variety of metabolic
capacity in terms of utilizing a variety of carbon sources under aerobic
conditions, respectively. This study reports the potential As3+-oxidizing
bacteria that can play an important role in subsurface arsenic
transformation that will aid in designing future bioremediation strategy
for the arsenic affected areas.
KW - Arsenic
KW - bacteria
KW - bioremediation
KW - characterization
KW - groundwater
KW - resistance
LA - eng
IS - 1532-2297 (Electronic)
PT - Journal Article
TA - Prep Biochem Biotechnol
YR - 2018
DATE- 20180611
CITO- NLM
CS - England
FJT - Preparative biochemistry &amp; biotechnology
EDAT- 20180611
STAT- Publisher
DOCNO- medline/29889593

35 - TOXLINE
TI - Arsenite downregulates H3K4 trimethylation and H3K9 dimethylation during
transformation of human bronchial epithelial cells.
AU - Tu W
AD - Department of Occupational and Environmental Health, Key Laboratory of
Environment and Health, Ministry of Education, School of Public Health, Tongji
Medical College, Huazhong University of Science and Technology, Wuhan, Hubei,
430030, People's Republic of China.
AU - Liu Y
AD - Department of Occupational and Environmental Health, Key Laboratory of
Environment and Health, Ministry of Education, School of Public Health, Tongji
Medical College, Huazhong University of Science and Technology, Wuhan, Hubei,
430030, People's Republic of China.
AU - Xie C
AD - Department of Occupational and Environmental Health, Key Laboratory of
Environment and Health, Ministry of Education, School of Public Health, Tongji
Medical College, Huazhong University of Science and Technology, Wuhan, Hubei,
430030, People's Republic of China.
AU - Zhou X
AD - Department of Occupational and Environmental Health, Key Laboratory of
Environment and Health, Ministry of Education, School of Public Health, Tongji
Medical College, Huazhong University of Science and Technology, Wuhan, Hubei,
430030, People's Republic of China.
SO - J Appl Toxicol. 2018, Apr; 38(4):480-488. [Journal of applied toxicology :
JAT]
AB - Arsenic is an established human carcinogen but with weak mutagenic
activity. The mechanisms of arsenic-induced carcinogenesis are not well
understood. In the present study, we investigated the role of histone
methylation in transformation of human bronchial epithelial (BEAS-2B)
cells. After 16 weeks' exposure, cells were transformed by 0.1, 0.5
and 1 &mu;m arsenite. Global trimethylated H3K4 (H3K4me3) was
decreased by 0.1 &mu;m arsenite at 12 weeks, and 0.5 and
1 &mu;m arsenite at 8, 12 and 16 weeks, which could be
attributed to reduced histone methyltransferase activities, increased
histone demethylase (HDM) activities as well as increased protein levels
of H3K4 demethylase KDM5A. Global dimethylated H3K9 (H3K9me2) was also
decreased after exposure to 0.5 &mu;m arsenite for 4, 8, 12 and
16 weeks and 1.0 &mu;m arsenite for 8 and 12 weeks, which
was associated with an increase of HDM activities. Our findings indicated
that arsenite decreased global H3K4me3 and H3K9me2 levels during cell
transformation by modulating the enzymatic activities of histone
methyltransferases and/or HDMs, and by upregulation of KDM5A protein
levels for H3K4me3.
KW - BEAS-2B cells
KW - H3K4 trimethylation
KW - H3K9 dimethylation
KW - arsenite
KW - cell transformation
LA - eng
IS - 1099-1263 (Electronic)
PT - Journal Article
TA - J Appl Toxicol
YR - 2018
DATE- 20180214
CI - Copyright &copy; 2017 John Wiley &amp; Sons, Ltd.
CITO- NLM
CS - England
FJT - Journal of applied toxicology : JAT
EDAT- 20171117
STAT- In-Data-Review
DOCNO- medline/29148585

36 - TOXLINE
TI - Associations between Methylated Metabolites of Arsenic and Selenium in
Urine of Pregnant Bangladeshi Women and Interactions between the Main
Genes Involved.
AU - Skr�der H
AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm,
Sweden.
AU - Engstr�m K
AD - Division of Occupational and Environmental Medicine, Department of Laboratory
Medicine, Lund University , Lund, Sweden.
AU - Kuehnelt D
AD - Institute of Chemistry, NAWI Graz, University of Graz, Graz, Austria.
AU - Kippler M
AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm,
Sweden.
AU - Francesconi K
AD - Institute of Chemistry, NAWI Graz, University of Graz, Graz, Austria.
AU - Nermell B
AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm,
Sweden.
AU - Tofail F
AD - International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b),
Dhaka, Bangladesh.
AU - Broberg K
AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm,
Sweden.
AU - Vahter M
AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm,
Sweden.
SO - Environ Health Perspect. 2018, 02 01; 126(2):027001. [Environmental health
perspectives]
AB - BACKGROUND: It has been proposed that interactions between selenium and
arsenic in the body may affect their kinetics and toxicity. However, it is
unknown how the elements influence each other in humans.
AB - OBJECTIVES: We aimed to investigate potential interactions in the
methylation of selenium and arsenic.
AB - METHODS: Urinary selenium (U-Se) and arsenic (U-As) were measured using
inductively coupled plasma mass spectrometry (ICPMS) in samples collected
from pregnant women (n=226) in rural Bangladesh at gestational weeks (GW)
8, 14, 19, and 30. Urinary concentrations of trimethyl selenonium ion
(TMSe) were measured by HPLC-vapor generation-ICPMS, as were inorganic
arsenic (iAs), methylarsonic acid (MMA), and dimethylarsinic acid (DMA).
Methylation efficiency was assessed based on relative amounts (%) of
arsenic and selenium metabolites in urine. Genotyping for the main
arsenite and selenium methyltransferases, AS3MT and INMT, was performed
using TaqMan probes or Sequenom.
AB - RESULTS: Multivariable-adjusted linear regression analyses indicated that
%TMSe (at GW8) was positively associated with %MMA (&beta;=1.3, 95% CI:
0.56, 2.0) and U-As, and inversely associated with %DMA and U-Se in
producers of TMSe (INMT rs6970396 AG+AA, n=74), who had a wide range of
urinary TMSe (12-42%). Also, %TMSe decreased in parallel to %MMA during
pregnancy, especially in the first trimester (-0.58 %TMSe per gestational
week). We found a gene-gene interaction for %MMA (p-interaction=0.076 for
haplotype 1). In analysis stratified by INMT genotype, the association
between %MMA and both AS3MT haplotypes 1 and 3 was stronger in women with
the INMT GG (TMSe nonproducers, 5th-95th percentile: 0.2-2%TMSe) vs. AG+AA
genotype.
AB - CONCLUSIONS: Our findings for Bangladeshi women suggest a positive
association between urinary %MMA and %TMSe. Genes involved in the
methylation of selenium and arsenic may interact on associations with
urinary %MMA. https://doi.org/10.1289/EHP1912.
LA - eng
IS - 1552-9924 (Electronic)
PT - Journal Article
TA - Environ Health Perspect
YR - 2018
DATE- 20180215
CITO- NLM
CS - United States
FJT - Environmental health perspectives
EDAT- 20180201
STAT- In-Data-Review
DOCNO- medline/29398653

37 - TOXLINE
TI - [Analysis of Arsenic Compounds in Blood and Urine by HPLC-ICP-MS].
AU - Lin L
AD - College of Criminal and Justice, East China University of Political Science
and Law, Shanghai 200042, China.
AU - Zhang SJ
AD - Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service
Platform, Academy of Forensic Science, Shanghai 200063, China.
AU - Xu WC
AD - School of Public Health, Southern Medical University, Guangzhou 510515,
China.
AU - Luo RX
AD - Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service
Platform, Academy of Forensic Science, Shanghai 200063, China.
AU - Ma D
AD - Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service
Platform, Academy of Forensic Science, Shanghai 200063, China.
AU - Shen M
AD - Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service
Platform, Academy of Forensic Science, Shanghai 200063, China.
SO - Fa Yi Xue Za Zhi. 2018, Feb; 34(1):37-43. [Fa yi xue za zhi]
AB - OBJECTIVES: To establish an analysis method for the detection of 6 arsenic
compounds [AsC, AsB, As&#65288;&#8546;&#65289;, DMA, MMA and
As&#65288;V&#65289;] in blood and urine by high-performance liquid
chromatography-inductively coupled plasma-mass spectrometry
&#65288;HPLC-ICP-MS&#65289;, and apply it to real cases.
AB - METHODS: Triton was used to damage cells, and then
EDTA&middot;2Na&middot;2H2O was used to complex arsenic compounds in
cells, and sonication and protein deposition by acetonitrile were
performed for sample pretreatment. With the mobile phase consisted of
ammonium carbonate and ultrapure water, gradient elution was performed for
obtaining the arsenic compounds in samples, which were analysed by ICP-MS
with Hamilton PRP-X100 column.
AB - RESULTS: The limits of detection in blood were 1.66-10 ng/mL, while the
lower limits of quantitation in blood ranged from 5 to 30 ng/mL. The
limits of detection in urine were 0.5-10 ng/mL, while the lower limits of
quantitation in urine were 5-30 ng/mL. The relative standard deviation of
inter-day and intra-day precisions was less than 10%. This method had been
successfully applied to 3 cases.
AB - CONCLUSIONS: This study has established an analysis method for detecting 6
common arsenic compounds in blood and urine, which can be used to detect
the arsenic compounds in the blood and urine from arsenic poisoning cases
as well as the patients under arsenic treatment.
COI - The authors of this article and the planning committee members and staff
have no relevant financial relationships with commercial interests to
disclose.
KW - arsenicals
KW - blood
KW - forensic toxicology
KW - high-performance liquid chromatography-inductively coupled plasma-mass
spectrometry (HPLC-ICP-MS)
KW - urine
LA - chi
IS - 1004-5619 (Print)
PT - Journal Article
TA - Fa Yi Xue Za Zhi
YR - 2018
DATE- 20180604
CI - Copyright&copy; by the Editorial Department of Journal of Forensic
Medicine.
CITO- NLM
CS - China
CSET- IM
FJT - Fa yi xue za zhi
EDAT- 20180225
STAT- MEDLINE
DOCNO- medline/29577703

38 - TOXLINE
TI - Lung, Bladder, and Kidney Cancer Mortality 40&thinsp;Years After Arsenic
Exposure Reduction.
AU - Smith AH
AD - Arsenic Health Effects Research Group, School of Public Health, University of
California, Berkeley, CA.
AU - Marshall G
AD - Departamento de Estad�stica, Facultad de Matem�ticas, Pontificia Universidad
Cat�lica de Chile, Santiago, Chile.
AU - Roh T
AD - Arsenic Health Effects Research Group, School of Public Health, University of
California, Berkeley, CA.
AU - Ferreccio C
AD - Advanced Center for Chronic Diseases, Escuela de Medicina, Pontificia
Universidad Cat�lica de Chile, Santiago, Chile.
AU - Liaw J
AD - Arsenic Health Effects Research Group, School of Public Health, University of
California, Berkeley, CA.
AU - Steinmaus C
AD - Arsenic Health Effects Research Group, School of Public Health, University of
California, Berkeley, CA.
SO - J Natl Cancer Inst. 2018, Mar 01; 110(3):241-249. [Journal of the National
Cancer Institute]
AB - Background: Region II in northern Chile (population 442&thinsp;570)
experienced a sudden major increase in arsenic water concentrations in
1958 in the main city of Antofagasta, followed by a major reduction in
exposure when an arsenic removal plant was installed in 1970. It provides
a unique opportunity to study latency effects of exposure to arsenic, and
this is the first study with mortality data up to 40&thinsp;years after
exposure reduction.
AB - Methods: We previously identified high mortality rates in Region II up to
the year 2000. Here we present rate ratios (RRs) for Region II compared
with all the rest of Chile from 2001 to 2010, and with unexposed Region V
(population 1&thinsp;539&thinsp;852) for all years from 1950 to 2010. All
statistical tests were one-sided.
AB - Results: From 2001 to 2010, comparing Region II with the rest of Chile,
lung and bladder mortality were still greatly elevated
(RR&thinsp;=&thinsp;3.38, 95% confidence interval [CI] = 3.19 to 3.58, P
< .001 for lung cancer in men; RR&thinsp;=&thinsp;2.41, 95%
CI&thinsp;=&thinsp;2.20 to 2.64, P < .001 for lung cancer in women;
RR&thinsp;=&thinsp;4.79, 95% CI&thinsp;=&thinsp;4.20 to 5.46, P < .001
for bladder cancer in men; RR&thinsp;=&thinsp;6.43, 95%
CI&thinsp;=&thinsp;5.49 to 7.54, P < .001 for bladder cancer in women).
Kidney cancer mortality was also elevated (RR&thinsp;=&thinsp;1.75, 95%
CI&thinsp;=&thinsp;1.49 to 2.05, P < .001 for men;
RR&thinsp;=&thinsp;2.09, 95% CI&thinsp;=&thinsp;1.69 to 2.57, P < .001
for women). Earlier short latency acute myocardial infarction mortality
increases had subsided.
AB - Conclusions: Lung, bladder, and kidney cancer mortality due to arsenic
exposure have very long latencies, with increased risks manifesting
40&thinsp;years after exposure reduction. Our findings suggest that
arsenic in drinking water may involve one of the longest cancer latencies
for a human carcinogen.
LA - eng
IS - 1460-2105 (Electronic)
PT - Journal Article
TA - J Natl Cancer Inst
YR - 2018
DATE- 20180319
CITO- NLM
CS - United States
FJT - Journal of the National Cancer Institute
STAT- In-Data-Review
DOCNO- medline/29069505

39 - TOXLINE
TI - Human health risks and socio-economic perspectives of arsenic exposure in
Bangladesh: A scoping review.
AU - Rahman MA
AD - Center for Infrastructure Engineering, Western Sydney University, Australia;
Faculty of Science and Technology, Federation University, Ballarat, Victoria,
Australia. Electronic address: rahmanmazizur@gmail.com.
AU - Rahman A
AD - Water and Environmental Engineering, School of Computing, Engineering and
Mathematics, Western Sydney University, Australia.
AU - Khan MZK
AD - Water and Environmental Engineering, School of Computing, Engineering and
Mathematics, Western Sydney University, Australia.
AU - Renzaho AMN
AD - Humanitarian and Development Research Initiative, School of Social Sciences
and Psychology, Western Sydney University, Australia.
SO - Ecotoxicol Environ Saf. 2018, Apr 15; 150:335-343. [Ecotoxicology and
environmental safety]
AB - Arsenic contamination of drinking water, which can occur naturally or
because of human activities such as mining, is the single most important
public health issue in Bangladesh. Fifty out of the 64 districts in the
country have arsenic concentration of groundwater exceeding 50&micro;gL-1,
the Bangladeshi threshold, affecting 35-77 million people or 21-48% of the
total population. Chronic arsenic exposure through drinking water and
other dietary sources is an important public health issue worldwide
affecting hundreds of millions of people. Consequently, arsenic poisoning
has attracted the attention of researchers and has been profiled
extensively in the literature. Most of the literature has focused on
characterising arsenic poisoning and factors associated with it. However,
studies examining the socio-economic aspects of chronic exposure of
arsenic through either drinking water or foods remain underexplored. The
objectives of this paper are (i) to review arsenic exposure pathways to
humans; (ii) to summarise public health impacts of chronic arsenic
exposure; and (iii) to examine socio-economic implications and
consequences of arsenicosis with a focus on Bangladesh. This scoping
review evaluates the contributions of different exposure pathways by
analysing arsenic concentrations in dietary and non-dietary sources. The
socio-economic consequences of arsenicosis disease in Bangladesh are
discussed in this review by considering food habits, nutritional status,
socio-economic conditions, and socio-cultural behaviours of the people of
the country. The pathways of arsenic exposure in Bangladesh include
drinking water, various plant foods and non-dietary sources such as soil.
Arsenic affected people are often abandoned by the society, lose their
jobs and get divorced and are forced to live a sub-standard life. The
fragile public health system in Bangladesh has been burdened by the
management of thousands of arsenicosis victims in Bangladesh.
KW - Arsenic exposure
KW - Bangladesh
KW - Public health
KW - Socio-cultural
KW - Socio-economic
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
PT - Review
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180515
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180104
STAT- MEDLINE
DOCNO- medline/29304476

40 - TOXLINE
TI - Health Risk Assessment and Urinary Excretion of Children Exposed to
Arsenic through Drinking Water and Soils in Sonora, Mexico.
AU - Garc�a-Rico L
AD - Programa de Doctorado en Ciencias Especialidad en Biotecnolog�a, Instituto
Tecnol�gico de Sonora, 5 de Febrero 818 Sur, 85000, Cd., Obreg�n, Sonora, Mexico.
AU - Meza-Figueroa D
AD - Departamento de Geolog�a, Divisi�n de Ciencias Exactas y Naturales,
Universidad de Sonora, Rosales y Encinas, 83000, Hermosillo, Sonora, Mexico.
AU - Jay Gandolfi A
AD - Department of Pharmacology and Toxicology, University of Arizona, 1723 E.
Mabel Street, Tucson, AZ, 85724, USA.
AU - Del Rivero CI
AD - Programa de Maestr�a, Departamento de Geolog�a, Divisi�n de Ciencias Exactas
y Naturales, Universidad de Sonora, Rosales y Encinas, 83000, Hermosillo, Sonora,
Mexico.
AU - Mart�nez-Cinco MA
AD - Divisi�n de Estudios de Posgrado, Facultad de Ingenier�a Qu�mica, Universidad
Michoacana de San Nicol�s de Hidalgo (UMSNH), Gral. Francisco J. M�gica SN,
Felicitas del R�o, 58040, Morelia, Michoac�n, Mexico.
AU - Meza-Montenegro MM
AD - Departamento de Recursos Naturales, Instituto Tecnol�gico de Sonora, 5 de
Febrero 818 Sur, 85000, Cd. Obreg�n, Sonora, Mexico. mmeza@itson.edu.mx.
SO - Biol Trace Elem Res. 2018, May 02. [Biological trace element research]
AB - Environmental arsenic exposure is associated with increased risk of
non-cancerous chronic diseases and a variety of cancers in humans. The
aims of this study were to carry out for the first time a health risk
assessment for two common arsenic exposure routes (drinking water and soil
ingestion) in children living in the most important agricultural areas in
the Yaqui and Mayo valleys in Sonora, Mexico. Drinking water sampling was
conducted in the wells of 57 towns. A cross-sectional study was done in
306 children from 13 villages in the valleys. First morning void urine
samples were analyzed for inorganic arsenic (InAs) and monomethyl and
dimethyl arsenic (MMA and DMA) by HPLC/ICP-MS. The results showed a wide
range of arsenic levels in drinking water between 2.7 and 98.7 &mu;g
As/L. Arsenic levels in agricultural and backyard soils were in the range
of < &thinsp;10-27 mg As/kg. The hazard index
(HI)&thinsp;=&thinsp;&sum;hazard quotient (HQ) for drinking water,
agricultural soil, and backyard soil showed values > &thinsp;1 in 100%
of the study towns, and the carcinogenic risk (CR) was greater than 1E-04
in 85%. The average of arsenic excreted in urine was 31.7 &mu;g As/L,
and DMA had the highest proportion in urine, with averages of 77.8%,
followed by InAs and MMA with 11.4 and 10.9%, respectively, percentages
similar to those reported in the literature. Additionally, positive
correlations between urinary arsenic levels and HI values were found
(r&thinsp;=&thinsp;0.59, P&thinsp;=&thinsp;0.000). These results indicated
that this population is at high risk of developing chronic diseases
including cancer.
KW - Arsenic
KW - Children
KW - Drinking water
KW - Health risk assessment
KW - Soil
KW - Urinary arsenic
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180503
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180502
STAT- Publisher
DOCNO- medline/29721859

41 - TOXLINE
TI - Ameliorative effects of selenium on arsenic-induced cytotoxicity in
PC12&#8239;cells via modulating autophagy/apoptosis.
AU - Rahman MM
AD - Graduate School of Environmental Science, Hokkaido University, Japan;
Department of Environmental Sciences, Jahangirnagar University, Bangladesh.
AU - Uson-Lopez RA
AD - Graduate School of Environmental Science, Hokkaido University, Japan.
AU - Sikder MT
AD - Faculty of Health Sciences, Hokkaido University, Japan.
AU - Tan G
AD - Graduate School of Environmental Science, Hokkaido University, Japan.
AU - Hosokawa T
AD - Institute for the Advancement of Higher Education, Hokkaido University,
Japan.
AU - Saito T
AD - Faculty of Health Sciences, Hokkaido University, Japan.
AU - Kurasaki M
AD - Graduate School of Environmental Science, Hokkaido University, Japan; Faculty
of Environmental Earth Science, Hokkaido University, Japan. Electronic address:
kura@ees.hokudai.ac.jp.
SO - Chemosphere. 2018, Apr; 196:453-466. [Chemosphere]
AB - Arsenic is well known toxicant responsible for human diseases including
cancers. On the other hand, selenium is an essential trace element with
significant chemopreventive effects, anticancer potentials and antioxidant
properties. Although previous studies have reported antagonism/synergism
between arsenic and selenium in biological systems, the biomolecular
mechanism/s is still inconclusive. Therefore, to elucidate the molecular
phenomena in cellular level, we hypothesized that co-exposure of selenium
with arsenic may have suppressive effects on arsenic-induced cytotoxicity.
We found that selenium in co-exposure with arsenic increases cell
viability, and suppresses oxidative stress induced by arsenic in
PC12&#8239;cells. Consequently, DNA fragmentation due to arsenic exposure
was also reduced by arsenic and selenium co-exposure. Furthermore, western
blot analyses revealed that simultaneous exposure of both metals
significantly inhibited autophagy which further suppressed apoptosis
through positively regulation of key proteins; p-mTOR, p-Akt, p-Foxo1A,
p62, and expression of ubiquitin, Bax, Bcl2, NF&#1082;B, and caspases 3
and 9, although those are negatively regulated by arsenic. In addition,
reverse transcriptase PCR analysis confirmed the involvement of caspase
cascade in cell death process induced by arsenic and subsequent inhibition
by co-exposure of selenium with arsenic. The cellular accumulation study
of arsenic in presence/absence of selenium via inductively coupled plasma
mass spectrometry confirmed that selenium effectively retarded the uptake
of arsenic in PC12&#8239;cells. Finally, these findings imply that
selenium is capable to modulate arsenic-induced intrinsic apoptosis
pathway via enhancement of mTOR/Akt autophagy signaling pathway through
employing antioxidant potentials and through inhibiting the cellular
accumulation of arsenic in PC12&#8239;cells.
KW - Apoptosis
KW - Autophagy
KW - Cytotoxicity
KW - Glutathione
KW - Malondialdehyde
KW - mTOR/Akt-pathway
RN - EC 2.7.1.1
RN - EC 2.7.1.1
RN - H6241UJ22B
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180312
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171228
STAT- MEDLINE
DOCNO- medline/29324385

42 - TOXLINE
TI - Arsenic removal from alkaline leaching solution using Fe (III)
precipitation.
AU - Wang Y
AD - a State Key Laboratory of Multiphase Complex System, Institute of Process
Engineering, Chinese Academy of Sciences , Beijing , People's Republic of China.
AU - Lv C
AD - b School of Chemistry and Chemical Engineering , University of Chinese
Academy of Sciences , Beijing , People's Republic of China.
AU - Xiao L
AD - b School of Chemistry and Chemical Engineering , University of Chinese
Academy of Sciences , Beijing , People's Republic of China.
AU - Fu G
AD - b School of Chemistry and Chemical Engineering , University of Chinese
Academy of Sciences , Beijing , People's Republic of China.
AU - Liu Y
AD - b School of Chemistry and Chemical Engineering , University of Chinese
Academy of Sciences , Beijing , People's Republic of China.
AU - Ye S
AD - a State Key Laboratory of Multiphase Complex System, Institute of Process
Engineering, Chinese Academy of Sciences , Beijing , People's Republic of China.
AU - Chen Y
AD - a State Key Laboratory of Multiphase Complex System, Institute of Process
Engineering, Chinese Academy of Sciences , Beijing , People's Republic of China.
SO - Environ Technol. 2018, Feb 02:1-7. [Environmental technology]
AB - The alkaline leaching solution from arsenic-containing gold concentrate
contains a large amount of arsenate ions, which should be removed because
it is harmful to the production process and to the environment. In this
study, conventional Fe (III) precipitation was used to remove arsenic from
the leaching solution. The precipitation reaction was carried out at the
normal temperature, and the effects of pH value and Fe/As ratio on the
arsenic removal were investigated. The results show that the removal rate
of arsenic is distinctive at different pH values, and the effect is best
within the pH range of 5.25-5.96. The removal rate can be further
increased by increasing the ratio of Fe/As. When the
pH&thinsp;=&thinsp;5.25-5.96 and Fe/As&thinsp; > &thinsp;1.8, the arsenic
in the solution can be reduced to below 5&#8197;mg/L. However, the
crystallinity of ferric arsenate is poor, and the particle size is small,
most of which is about 1&#8197;&mu;m. The leaching toxicity test shows the
leaching toxicity of precipitates gradually decreased by the increase of
Fe/As. The precipitates can be stored safely as the ratio of Fe/As
exceeded 2.5.
KW - Arsenic precipitates
KW - Fe/As ratio
KW - ferric arsenate
KW - leaching toxicity
LA - eng
IS - 0959-3330 (Print)
PT - Journal Article
TA - Environ Technol
YR - 2018
DATE- 20180202
CITO- NLM
CS - England
FJT - Environmental technology
EDAT- 20180202
STAT- Publisher
DOCNO- medline/29345188

43 - TOXLINE
TI - A novel biodegradable arsenic adsorbent by immobilization of iron
oxyhydroxide (FeOOH) on the root powder of long-root Eichhornia crassipes.
AU - Lin S
AD - State Environmental Protection Key Laboratory of Environmental Risk
Assessment and Control on Chemical Process, East China University of Science and
Technology, Shanghai, 200237, China. Electronic address: linsen@ecust.edu.cn.
AU - Yang H
AD - Yunnan Research Institute of Ecological Agriculture, Yunnan, 610203, China.
AU - Na Z
AD - Yunnan Research Institute of Ecological Agriculture, Yunnan, 610203, China.
AU - Lin K
AD - State Environmental Protection Key Laboratory of Environmental Risk
Assessment and Control on Chemical Process, East China University of Science and
Technology, Shanghai, 200237, China. Electronic address: linkuangfei@ecust.edu.cn.
SO - Chemosphere. 2018, Feb; 192:258-266. [Chemosphere]
AB - In this study, FeOOH was immobilized on the biodegradable root powder,
abbreviated as RP, of long-root Eichhornia crassipes, a kind of waste
biomass, to improve the adsorption performances for aqueous arsenic
contaminants. The adsorption kinetics and thermodynamics experiments
showed that the adsorption rates and capacities of the root powder for
arsenate (As(V)) and arsenite (As(III)) were both enhanced markedly after
modification with FeOOH. The adsorption of As(V) and As(III) by the
modified root powder, abbreviated as MRP, could arrive at equilibrium in
50 min and the saturated adsorption capacities reached up to
8.67-9.43 mg/g for As(V) and 5.21-5.65 mg/g for As(V) at
temperature of 10-50 &deg;C, respectively. Besides, the effect of pH
and ionic strength on adsorption was investigated and the results showed
that the optimum pH for the arsenic adsorption using the MRP was 9.0 and
the As(V) adsorption was more sensitive to ionic strength. Furthermore,
the complexation of hydratable hydroxyls on FeOOH with arsenic
contaminants was concluded as the adsorption force according FTIR and XPS
analyses. The MRP used could be regenerated via 0.4 mol/L NaOH
solution and no apparent adsorption capacity losses appeared after 6
cyclic utilizations.
KW - Arsenic adsorption
KW - Complexation
KW - Hydratable hydroxyls
KW - Immobilization
KW - Long-root Eichhornia crassipes
RN - 2UA751211N
RN - N5509X556J
RN - N712M78A8G
RN - N7CIZ75ZPN
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180130
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171030
STAT- MEDLINE
DOCNO- medline/29107877

44 - TOXLINE
TI - In Vitro Model To Assess Arsenic Bioaccessibility and Speciation in Cooked
Shrimp.
AU - Chi H
AD - State Key Laboratory of Urban Environment and Health, Institute of Urban
Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's
Republic of China.
AU - Zhang Y
AD - State Key Laboratory of Urban Environment and Health, Institute of Urban
Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's
Republic of China.
AU - Williams PN
AD - Institute for Global Food Security, School of Biological Sciences , Queen's
University Belfast , Belfast BT9 7BL , United Kingdom.
AU - Lin S
AD - State Key Laboratory of Urban Environment and Health, Institute of Urban
Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's
Republic of China.
AU - Hou Y
AD - Department of Environmental Science and Engineering , Huaqiao University ,
Xiamen , Fujian 361021 , People's Republic of China.
AU - Cai C
AD - State Key Laboratory of Urban Environment and Health, Institute of Urban
Environment , Chinese Academy of Sciences , Xiamen , Fujian 361021 , People's
Republic of China.
SO - J Agric Food Chem. 2018, May 09; 66(18):4710-4715. [Journal of
agricultural and food chemistry]
AB - Shrimp, a popular and readily consumed seafood, contains high
concentrations of arsenic. However, few studies have focused on whether
arsenic in the shrimp could be transformed during the cooking process and
gastrointestinal digestion. In this study, a combined in vitro model
[Unified Bioaccessibility Research Group of Europe (BARGE)
Method-Simulator of Human Intestinal Microbial Ecosystem (UBM-SHIME)] was
used to investigate arsenic bioaccessibility and its speciation in raw and
cooked shrimps. The results showed that the cooking practices had little
effect on the arsenic content and speciation. Bioaccessibility of arsenic
in raw shrimp was at a high level, averaging 76.9 &plusmn; 4.28 and 86.7
&plusmn; 3.74% in gastric and small intestinal phases, respectively.
Arsenic speciation was stable in all of the shrimp digestions, with
nontoxic arsenobetaine (AsB) being the dominated speciation. The cooking
practice significantly increased the bioaccessibility of arsenate ( p <
0.05) in shrimp digests, indicating the increase of the potential health
risks.
KW - arsenic
KW - bioaccessibility
KW - in vitro model
KW - shrimp
KW - speciation
RN - N712M78A8G
LA - eng
IS - 1520-5118 (Electronic)
PT - Journal Article
TA - J Agric Food Chem
YR - 2018
DATE- 20180523
CITO- NLM
CS - United States
CSET- IM
FJT - Journal of agricultural and food chemistry
EDAT- 20180424
STAT- MEDLINE
DOCNO- medline/29633616

45 - TOXLINE
TI - Low-level arsenic causes proteotoxic stress and not oxidative stress.
AU - Dodson M
AD - Department of Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ 85721, USA.
AU - de la Vega MR
AD - Department of Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ 85721, USA.
AU - Harder B
AD - Department of Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ 85721, USA.
AU - Castro-Portuguez R
AD - Department of Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ 85721, USA.
AU - Rodrigues SD
AD - Department of Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ 85721, USA.
AU - Wong PK
AD - Department of Biomedical Engineering, The Pennsylvania State University,
University Park, PA 16802, USA.
AU - Chapman E
AD - Department of Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ 85721, USA.
AU - Zhang DD
AD - Department of Pharmacology and Toxicology, College of Pharmacy, University of
Arizona, Tucson, AZ 85721, USA; Arizona Cancer Center, University of Arizona,
Tucson, AZ 85724, USA. Electronic address: dzhang@pharmacy.arizona.edu.
SO - Toxicol Appl Pharmacol. 2018, Feb 15; 341:106-113. [Toxicology and applied
pharmacology]
AB - Prolonged exposure to arsenic has been shown to increase the risk of
developing a number of diseases, including cancer and type II diabetes.
Arsenic is present throughout the environment in its inorganic forms, and
the level of exposure varies greatly by geographical location. The current
recommended maximum level of arsenic exposure by the EPA is 10&mu;g/L, but
levels > 50-1000&mu;g/L have been detected in some parts of Asia, the
Middle East, and the Southwestern United States. One of the most important
steps in developing treatment options for arsenic-linked pathologies is to
understand the cellular pathways affected by low levels of arsenic. Here,
we show that acute exposure to non-lethal, low-level arsenite, an
environmentally relevant arsenical, inhibits the autophagy pathway.
Furthermore, arsenite-induced autophagy inhibition initiates a transient,
but moderate ER stress response. Significantly, low-level arsenite
exposure does not exhibit an increase in oxidative stress. These findings
indicate that compromised autophagy, and not enhanced oxidative stress
occurs early during arsenite exposure, and that restoring the autophagy
pathway and proper proteostasis could be a viable option for treating
arsenic-linked diseases. As such, our study challenges the existing
paradigm that oxidative stress is the main underlying cause of pathologies
associated with environmental arsenic exposure.
KW - Arsenic
KW - Autophagy inhibitor
KW - ER stress
KW - Oxidative stress
KW - Proteostasis
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180503
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20180203
STAT- In-Data-Review
CM - Cites: Environ Health Perspect. 2016 Jan;124(1):104-11 (medline /26068977)
CM - Cites: Environ Health Perspect. 2000 Jul;108(7):655-61 (medline /10903620)
CM - Cites: Toxicol Sci. 2007 Feb;95(2):321-30 (medline /17093206)
CM - Cites: Toxicol Lett. 2003 Jan 31;137(1-2):15-21 (medline /12505429)
CM - Cites: J Appl Toxicol. 2016 Feb;36(2):179-88 (medline /26510484)
CM - Cites: Water Res. 2014 Jan 1;48:156-69 (medline /24094730)
CM - Cites: Sci Total Environ. 2006 Aug 1;366(2-3):701-21 (medline /16203025)
CM - Cites: Arch Toxicol. 2012 Jun;86(6):923-33 (medline /22622864)
CM - Cites: Toxicol Appl Pharmacol. 2001 Oct 15;176(2):127-44 (medline
/11601889)
CM - Cites: Arch Toxicol. 2000 Aug;74(6):289-99 (medline /11005674)
CM - Cites: Toxicol Appl Pharmacol. 2001 Sep 15;175(3):260-8 (medline
/11559025)
CM - Cites: Mol Cell Biol. 2013 Jun;33(12 ):2436-46 (medline /23589329)
CM - Cites: Environ Health Perspect. 2012 Dec;120(12 ):1658-70 (medline
/22889723)
CM - Cites: Toxicology. 2009 Aug 3;262(2):162-70 (medline /19524636)
CM - Cites: Onco Targets Ther. 2013;6:75-84 (medline /23404534)
CM - Cites: J Exp Clin Cancer Res. 2014 May 16;33:42 (medline /24887205)
CM - Cites: Curr Environ Health Rep. 2015 Mar;2(1):52-68 (medline /26231242)
CM - Cites: Chem Rev. 2013 Oct 9;113(10):7769-92 (medline /23808632)
CM - Cites: Environ Health Perspect. 2008 Feb;116(2):190-5 (medline /18288317)
CM - Cites: Science. 2002 Nov 22;298(5598):1602-6 (medline /12446905)
CM - Cites: Free Radic Biol Med. 2013 Oct;63:207-21 (medline /23702245)
CM - Cites: Environ Toxicol Pharmacol. 2013 Nov;36(3):891-902 (medline
/24004876)
CM - Cites: JAMA. 2008 Aug 20;300(7):814-22 (medline /18714061)
CM - Cites: Curr Pharmacol Rep. 2016 Apr;2(2):57-63 (medline /27134817)
CM - Cites: Cancer Res. 2010 Jun 15;70(12):5127-35 (medline /20516118)
CM - Cites: Free Radic Biol Med. 1999 Dec;27(11-12):1405-12 (medline /10641735)
CM - Cites: Environ Health Perspect. 2000 May;108(5):393-7 (medline /10811564)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):243-52 (medline
/15276403)
CM - Cites: J Toxicol. 2011;2011:431287 (medline /22174709)
CM - Cites: Am J Epidemiol. 2014 Dec 1;180(11):1082-7 (medline /25371173)
CM - Cites: Autophagy. 2007 Sep-Oct;3(5):452-60 (medline /17534139)
CM - Cites: Environ Toxicol. 2017 Jan;32(1):197-216 (medline /26677073)
CM - Cites: Environ Int. 2008 Aug;34(6):756-64 (medline /18291528)
CM - Cites: Toxicol Sci. 2015 Aug;146(2):290-300 (medline /25979314)
CM - Cites: Toxicol Sci. 2011 Oct;123(2):305-32 (medline /21750349)
CM - Cites: Environ Health Perspect. 2006 Aug;114(8):1193-8 (medline /16882524)
CM - Cites: Environ Health Perspect. 2013 Feb;121(2):237-43 (medline /23221991)
CM - Cites: J Hazard Mater. 2017 Jan 5;321:432-439 (medline /27669384)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):623-30 (medline
/23355602)
CM - Cites: Cancer Res. 2005 Apr 15;65(8):3236-42 (medline /15833855)
CM - Cites: Toxicol Lett. 2014 Jan 3;224(1):130-40 (medline /24157283)
DOCNO- medline/29408041
46 - TOXLINE
TI - Enhanced oxidation of arsenite to arsenate using tunable K+ concentration
in the OMS-2 tunnel.
AU - Hou J
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River), Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan, 430070, China; State Key Laboratory of
Silicate Materials for Architectures, Wuhan University of Technology, Wuhan,
430070, China. Electronic address: jthou@mail.hzau.edu.cn.
AU - Sha Z
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River), Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan, 430070, China.
AU - Hartley W
AD - Crop and Environment Sciences Department, Harper Adams University, Newport,
Shropshire, TF10 8NB, United Kingdom.
AU - Tan W
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River), Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan, 430070, China.
AU - Wang M
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River), Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan, 430070, China.
AU - Xiong J
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River), Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan, 430070, China.
AU - Li Y
AD - State Key Laboratory of Silicate Materials for Architectures, Wuhan
University of Technology, Wuhan, 430070, China.
AU - Ke Y
AD - School of Materials Science and Engineering, Nanyang Technological
University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
AU - Long Y
AD - School of Materials Science and Engineering, Nanyang Technological
University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
AU - Xue S
AD - Department of Environmental Engineering, School of Metallurgy and
Environment, Central South University, Changsha, 410083, China; Chinese National
Engineering Research Centre for Control and Treatment of Heavy Metal Pollution,
Changsha, 410083, China.
SO - Environ Pollut. 2018, Jul; 238:524-531. [Environmental pollution (Barking,
Essex : 1987)]
AB - Cryptomelane-type octahedral molecular sieve manganese oxide (OMS-2)
possesses high redox potential and has attracted much interest in its
application for oxidation arsenite (As(III)) species of arsenic to
arsenate (As(V)) to decrease arsenic toxicity and promote total arsenic
removal. However, coexisting ions such as As(V) and phosphate are
ubiquitous and readily bond to manganese oxide surface, consequently
passivating surface active sites of manganese oxide and reducing As(III)
oxidation. In this study, we present a novel strategy to significantly
promote As(III) oxidation activity of OMS-2 by tuning K+ concentration in
the tunnel. Batch experimental results reveal that increasing K+
concentration in the tunnel of OMS-2 not only considerably improved
As(III) oxidation kinetics rate from 0.027 to 0.102 min-1, but also
reduced adverse effect of competitive ion on As(III) oxidation. The origin
of K+ concentration effect on As(III) oxidation was investigated through
As(V) and phosphate adsorption kinetics, detection of Mn2+ release in
solution, surface charge characteristics, and density functional theory
(DFT) calculations. Experimental results and theoretical calculations
confirm that by increasing K+ concentration in the OMS-2 tunnel not only
does it improve arsenic adsorption on K+ doped OMS-2, but also accelerates
two electrons transfers from As(III) to each bonded Mn atom on OMS-2
surface, thus considerably improving As(III) oxidation kinetics rate,
which is responsible for counteracting the adverse adsorption effects by
coexisting ions.
KW - Arsenate
KW - Arsenite oxidation
KW - Competitive adsorption
KW - K(+) doping
KW - OMS-2
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180515
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180330
STAT- In-Process
DOCNO- medline/29605612

47 - TOXLINE
TI - Chronic Arsenic Exposure Increases A&beta;(1-42) Production and Receptor
for Advanced Glycation End Products Expression in Rat Brain.
AU - Ni�o SA
AD - Centro de Biociencias, Universidad Aut�noma de San Luis Potos� , Km. 14.5
carretera San Luis Potos� - Matehuala, Ejido "Palma de la Cruz", CP 78321 Soledad
de Graciano S�nchez, San Luis Potos�, M�xico.
AU - Martel-Gallegos G
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Castro-Zavala A
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Ortega-Berlanga B
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Delgado JM
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Hern�ndez-Mendoza H
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Romero-Guzm�n E
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - R�os-Lugo J
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Rosales-Mendoza S
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Jim�nez-Capdeville ME
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
AU - Zaraz�a S
AD - Laboratorio Nacional Forense Nuclear, Instituto Nacional de Investigaciones
Nucleares , Carretera M�xico-Toluca s/n, CP 52750 La Marquesa Ocoyoacac, M�xico.
SO - Chem Res Toxicol. 2018, Jan 16; 31(1):13-21. [Chemical research in
toxicology]
AB - Chronic arsenic exposure during development is associated with alterations
of chemical transmission and demyelination, which result in cognitive
deficits and peripheral neuropathies. At the cellular level, arsenic
toxicity involves increased generation of reactive species that induce
severe cellular alterations such as DNA fragmentation, apoptosis, and
lipid peroxidation. It has been proposed that arsenic-associated
neurodegeneration could evolve to Alzheimer disease in later life.1,2 In
this study, the effects of chronic exposure to inorganic arsenic (3 ppm by
drinking water) in Wistar rats on the production and elimination of
Amyloid-&beta; (A&beta;) were evaluated. Male Wistar rats were exposed to
3 ppm of arsenic in drinking water from fetal development until 4 months
of age. After behavioral deficits induced by arsenic exposure through
contextual fear conditioning were verified, the brains were collected for
the determination of total arsenic by inductively coupled plasma-mass
spectrometry, the levels of amyloid precursor protein and receptor for
advanced glycation end products (RAGE) by Western blot analysis as well as
their transcript levels by RT-qPCR, A&beta;(1-42) estimation by ELISA
assay and the enzymatic activity of &beta;-secretase (BACE1). Our results
demonstrate that chronic arsenic exposure induces behavioral deficits
accompanied of higher levels of soluble and membranal RAGE and the
increase of A&beta;(1-42) cleaved. In addition, BACE1 enzymatic activity
was increased, while immunoblot assays showed no differences in the
low-density lipoprotein receptor-related protein 1 (LRP1) receptor among
groups. These results provide evidence of the effects of arsenic exposure
on the production of A&beta;(1-42) and cerebral amyloid clearance through
RAGE in an in vivo model that displays behavioral alterations. This work
supports the hypothesis that early exposure to metals may contribute to
neurodegeneration associated with amyloid accumulation.
LA - eng
IS - 1520-5010 (Electronic)
PT - Journal Article
TA - Chem Res Toxicol
YR - 2018
DATE- 20180116
CITO- NLM
CS - United States
FJT - Chemical research in toxicology
EDAT- 20171204
STAT- In-Data-Review
DOCNO- medline/29155576

48 - TOXLINE
TI - Arsenic uptake by arugula (Eruca vesicaria, L.) cultivars as affected by
phosphate availability.
AU - Tang X
AD - Institute of Hydrobiology, Jinan University, Guangzhou, 510632, China.
AU - Lim MP
AD - Section of Soil and Crop Sciences, School of Integrative Plant Science,
Cornell University, Ithaca, NY, 14850, USA.
AU - McBride MB
AD - Section of Soil and Crop Sciences, School of Integrative Plant Science,
Cornell University, Ithaca, NY, 14850, USA. Electronic address: mbm7@cornell.edu.
SO - Chemosphere. 2018, Mar; 195:559-566. [Chemosphere]
AB - To assess the importance of variation among arugula (Eruca vesicaria
subsp. sativa) cultivars in the ability to accumulate arsenic (As) in
above-ground tissues, uptake of As by 16 cultivars was measured in the
field and in hydroponic culture. In the field trial on soil contaminated
by past pesticide use, As soil-plant uptake coefficients varied by a
factor of 2.7 among different cultivars, approaching a value of one for
the strongest accumulators. Compared to the field assay, hydroponically
grown arugula accumulated much lower concentrations of As when nutrient
solutions contained standard (high) concentrations of phosphate along with
1.0&#8239;mg&#8239;L-1 As in the form of soluble arsenate. However, As
accumulation was much greater in hydroponic culture using low-P nutrient
solutions, an indication that phosphate strongly competed with arsenate
for root uptake. Analysis of arugula roots after exposure to arsenate at
1.0&#8239;mg As L-1 and low phosphate revealed from 24 to 400 times
greater As concentration in roots than tops, with S concentrations
significantly greater in As-exposed than control roots. This indicated
greater sulfate uptake by roots exposed to arsenate, and suggested that
thiol-mediated As immobilization occurred in the roots which strongly
restricted translocation to the tops.
KW - Arsenic bioaccumulation
KW - Arsenic immobilization in roots
KW - Arugula cultivars
KW - Brassicas
KW - Genetic variation
RN - N712M78A8G
RN - N7CIZ75ZPN
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180606
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171227
STAT- MEDLINE
DOCNO- medline/29277036

49 - TOXLINE
TI - Arsenic in agricultural soils across China: Distribution pattern,
accumulation trend, influencing factors, and risk assessment.
AU - Zhou Y
AD - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College
of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058,
China.
AU - Niu L
AD - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College
of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058,
China.
AU - Liu K
AD - Division of Engineering and Applied Science, California Institute of
Technology, Pasadena, CA 91125, USA. Electronic address: kliu7@caltech.edu.
AU - Yin S
AD - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College
of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058,
China.
AU - Liu W
AD - MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College
of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058,
China. Electronic address: wliu@zju.edu.
SO - Sci Total Environ. 2018, Mar; 616-617:156-163. [The Science of the total
environment]
AB - Arsenic (As) in the environment is of concern due to its strong toxicity
and high risks to the ecosystems and humans. In this study, soil samples
across China collected in 2011 and 2016 were used to determine the
concentrations of arsenic in arable soils. The median concentration of
arsenic in surface soils was 9.7mg/kg. The inventory of arsenic in the
Chinese agricultural surface soils was estimated to be 3.7&times;106tons.
In general, arsenic contamination was found higher in South and Northeast
China than in other regions, with means of 18.7 and 15.8mg/kg,
respectively. Vertically, arsenic concentrations were higher in top layer
(0-15cm) soils (median of 9.8mg/kg) and decreased with soil depth (medians
of 8.9mg/kg at 15-30cm and 8.0mg/kg at 30-45cm). By comparing with
published data, an increasing accumulation trend over the past decades was
found and this enhancement was positively related with the long-term
application of fertilizers in agricultural practice, especially phosphate
fertilizers. Soil pH was found to affect the movement of arsenic in soil,
and high-pH conditions enhanced the pool of arsenic. The ecological risk
assessment revealed that arsenic in Chinese agricultural soil posed a low
risk to the ecosystem. Regarding human health, the mean hazard indices
(HIs) of arsenic were below 1, suggesting an absence of non-carcinogenic
risks. In addition, the cancer risks of arsenic in all soil samples were
within the acceptable range (below 1&times;10-4), indicating low to very
low risks to the exposed population. Findings from this study are valuable
to provide effective management options for risk avoidance and to control
the persistent accumulation of arsenic in the agriculture sector across
the world.
KW - Accumulation trend
KW - Agricultural soil
KW - Arsenic
KW - Distribution pattern
KW - Ecological and human health risk
RN - N712M78A8G
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180514
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20171104
STAT- MEDLINE
DOCNO- medline/29112838

50 - TOXLINE
TI - Effect of the natural arsenic gradient on the diversity and arsenic
resistance of bacterial communities of the sediments of Camarones River
(Atacama Desert, Chile).
AU - Leon CG
AD - Environmental Microbiology Laboratory, Department of Microbiology, Faculty of
Biological Sciences, University of Concepci�n, Concepci�n, Chile.
AU - Moraga R
AD - Microbiology Laboratory, Faculty of Renewable Natural Resources, Arturo Prat
University, Iquique, Chile.
AU - Valenzuela C
AD - Environmental Microbiology Laboratory, Department of Microbiology, Faculty of
Biological Sciences, University of Concepci�n, Concepci�n, Chile.
AU - Gugliandolo C
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Messina, Italy.
AU - Lo Giudice A
AD - Institute for the Coastal Marine Environment, National Research Council
(IAMC-CNR), Messina, Italy.
AU - Papale M
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Messina, Italy.
AU - Vilo C
AD - Environmental Microbiology Laboratory, Department of Microbiology, Faculty of
Biological Sciences, University of Concepci�n, Concepci�n, Chile.
AU - Dong Q
AD - Center for Biomedical Informatics, Department of Public Health Sciences,
Loyola University Chicago, Maywood, Illinois, United States of America.
AU - Smith CT
AD - Environmental Microbiology Laboratory, Department of Microbiology, Faculty of
Biological Sciences, University of Concepci�n, Concepci�n, Chile.
AU - Rossello-Mora R
AD - Marine Microbiology Group, Institut Mediterrani d'Estudis Avancats (CSIC-
UIB), Esporles, Spain.
AU - Ya�ez J
AD - Department of Analytical and Inorganic Chemistry, Faculty of Chemical
Sciences, University of Concepcion, Concepcion, Chile.
AU - Campos VL
AD - Environmental Microbiology Laboratory, Department of Microbiology, Faculty of
Biological Sciences, University of Concepci�n, Concepci�n, Chile.
SO - PLoS One. 2018; 13(5):e0195080. [PloS one]
AB - Arsenic (As), a highly toxic metalloid, naturally present in Camarones
River (Atacama Desert, Chile) is a great health concern for the local
population and authorities. In this study, the taxonomic and functional
characterization of bacterial communities associated to metal-rich
sediments from three sites of the river (sites M1, M2 and M3), showing
different arsenic concentrations, were evaluated using a combination of
approaches. Diversity of bacterial communities was evaluated by Illumina
sequencing. Strains resistant to arsenic concentrations varying from 0.5
to 100 mM arsenite or arsenate were isolated and the presence of genes
coding for enzymes involved in arsenic oxidation (aio) or reduction (arsC)
investigated. Bacterial communities showed a moderate diversity which
increased as arsenic concentrations decreased along the river. Sequences
of the dominant taxonomic groups (abundances &ge;1%) present in all three
sites were affiliated to Proteobacteria (range 40.3-47.2%), Firmicutes
(8.4-24.8%), Acidobacteria (10.4-17.1%), Actinobacteria (5.4-8.1%),
Chloroflexi (3.9-7.5%), Planctomycetes (1.2-5.3%), Gemmatimonadetes
(1.2-1.5%), and Nitrospirae (1.1-1.2%). Bacterial communities from sites
M2 and M3 showed no significant differences in diversity between each
other (p = 0.9753) but they were significantly more diverse than M1
(p < 0.001 and p < 0.001, respectively). Sequences affiliated with
Proteobacteria, Firmicutes, Acidobacteria, Chloroflexi and Actinobacteria
at M1 accounted for more than 89% of the total classified bacterial
sequences present but these phyla were present in lesser proportions in M2
and M3 sites. Strains isolated from the sediment of sample M1, having the
greatest arsenic concentration (498 mg kg-1), showed the largest
percentages of arsenic oxidation and reduction. Genes aio were more
frequently detected in isolates from M1 (54%), whereas arsC genes were
present in almost all isolates from all three sediments, suggesting that
bacterial communities play an important role in the arsenic biogeochemical
cycle and detoxification of arsenical compounds. Overall, results provide
further knowledge on the microbial diversity of arsenic contaminated
fresh-water sediments.
LA - eng
IS - 1932-6203 (Electronic)
PT - Journal Article
TA - PLoS One
YR - 2018
DATE- 20180513
CITO- NLM
CS - United States
FJT - PloS one
EDAT- 20180501
STAT- In-Data-Review
CM - Cites: J Environ Monit. 2005 Dec;7(12):1335-41 (medline /16307093)
CM - Cites: PLoS One. 2014 Apr 22;9(4):e95655 (medline /24755825)
CM - Cites: Biochimie. 2009 Oct;91(10):1229-37 (medline /19567262)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2015;50(1):1-8
(medline /25438126)
CM - Cites: Annu Rev Microbiol. 2006;60:107-30 (medline /16704340)
CM - Cites: Extremophiles. 2009 May;13(3):557-65 (medline /19363644)
CM - Cites: J Biol Chem. 1992 Nov 25;267(33):23674-82 (medline /1331097)
CM - Cites: Bull Environ Contam Toxicol. 2009 Nov;83(5):657-61 (medline
/19779656)
CM - Cites: Environ Sci Technol. 2001 Sep 15;35(18):3676-82 (medline /11783644)
CM - Cites: Int J Syst Evol Microbiol. 2006 Aug;56(Pt 8):1765-9 (medline
/16902005)
CM - Cites: Arch Biochem Biophys. 1991 Feb 1;284(2):381-5 (medline /1703401)
CM - Cites: Biochim Biophys Acta. 2004 Jun 7;1656(2-3):148-55 (medline
/15178476)
CM - Cites: J Hazard Mater. 2000 Aug 28;76(1):125-38 (medline /10863019)
CM - Cites: PLoS One. 2014 Oct 09;9(10):e108185 (medline /25299175)
CM - Cites: Biosci Biotechnol Biochem. 2014;78(11):1963-70 (medline /25051896)
CM - Cites: Environ Microbiol. 2007 Apr;9(4):934-43 (medline /17359265)
CM - Cites: J Bacteriol. 2010 Jul;192(14):3755-62 (medline /20453090)
CM - Cites: Arch Environ Contam Toxicol. 2011 Aug;61(2):185-92 (medline
/20859623)
CM - Cites: Reprod Toxicol. 1995 Mar-Apr;9(2):105-13 (medline /7795320)
CM - Cites: Bioinformatics. 2011 Aug 15;27(16):2194-200 (medline /21700674)
CM - Cites: Front Microbiol. 2015 May 06;6:360 (medline /25999920)
CM - Cites: J Bacteriol. 2006 Feb;188(3):1081-8 (medline /16428412)
CM - Cites: Appl Environ Microbiol. 2008 Jul;74(14):4567-73 (medline /18502920)
CM - Cites: PLoS One. 2012;7(6):e40059 (medline /22768219)
CM - Cites: Biodegradation. 2012 Nov;23(6):803-12 (medline /22760225)
CM - Cites: Environ Microbiol. 2015 Jun;17(6):1991-2005 (medline /25244307)
CM - Cites: Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6 (medline
/23193283)
CM - Cites: J Bacteriol. 2012 Jan;194(2):207-8 (medline /22056935)
CM - Cites: Rev Med Chil. 2010 Apr;138(4):461-9 (medline /20668794)
CM - Cites: FEMS Microbiol Rev. 1999 Oct;23(5):615-27 (medline /10525169)
CM - Cites: J Bacteriol. 2003 Jan;185(1):135-41 (medline /12486049)
CM - Cites: Environ Toxicol Chem. 2001 Nov;20(11):2639-43 (medline /11699792)
CM - Cites: Environ Sci Technol. 2004 Jan 1;38(1):104-11 (medline /14740724)
CM - Cites: PLoS One. 2015 Mar 05;10(3):e0119465 (medline /25742617)
CM -Cites: Chemosphere. 2007 Jan;66(4):775-82 (medline /16949129)
CM -Cites: PLoS One. 2017 May 5;12 (5):e0176696 (medline /28475654)
CM -Cites: J Appl Microbiol. 2002;93(4):656-67 (medline /12234349)
CM -Cites: Chemosphere. 2009 Sep;77(2):169-74 (medline /19716583)
CM -Cites: J Basic Microbiol. 2009 Sep;49 Suppl 1:S93-7 (medline /19718679)
CM -Cites: J Biosci Bioeng. 2014 Jul;118(1):1-9 (medline /24507904)
CM -Cites: World J Microbiol Biotechnol. 2012 Apr;28(4):1511-21 (medline
/22805933)
CM - Cites: J Bacteriol. 2012 Aug;194(16):4473-4 (medline /22843599)
CM - Cites: Environ Sci Technol. 2010 Jan 1;44(1):15-23 (medline /20000681)
CM - Cites: PLoS One. 2013 Aug 30;8(8):e72535 (medline /24023621)
CM - Cites: BMC Microbiol. 2009 Jan 08;9:4 (medline /19128515)
CM - Cites: Trends Microbiol. 2005 Feb;13(2):45-9 (medline /15680760)
CM - Cites: Biometals. 2009 Feb;22(1):117-30 (medline /19130261)
CM - Cites: Environ Sci Technol. 2001 Oct 1;35(19):3857-62 (medline /11642444)
CM - Cites: Appl Environ Microbiol. 2010 Jul;76(13):4566-70 (medline /20453153)
CM - Cites: Appl Environ Microbiol. 2002 Jan;68(1):280-8 (medline /11772637)
CM - Cites: Bull Environ Contam Toxicol. 2009 May;82(5):593-6 (medline
/19190837)
CM - Cites: Sci Rep. 2017 Feb 06;7:42037 (medline /28165031)
CM - Cites: Curr Microbiol. 2012 Aug;65(2):212-8 (medline /22638843)
CM - Cites: Res Microbiol. 2007 Mar;158(2):128-37 (medline /17258434)
CM - Cites: J Hazard Mater. 2006 Dec 1;138(3):459-70 (medline /17049728)
CM - Cites: Front Microbiol. 2016 Dec 06;7:1917 (medline /27999565)
DOCNO- medline/29715297

51 - TOXLINE
TI - Sensitive arsenic speciation by capillary electrophoresis using UV
absorbance detection with on-line sample preconcentration techniques.
AU - Lee HG
AD - Department of Chemistry, Seoul National University, Seoul 08826, Republic of
Korea.
AU - Kwon JY
AD - Department of Chemistry, Seoul National University, Seoul 08826, Republic of
Korea.
AU - Chung DS
AD - Department of Chemistry, Seoul National University, Seoul 08826, Republic of
Korea. Electronic address: dschung@snu.ac.kr.
SO - Talanta. 2018, May 01; 181:366-372. [Talanta]
AB - The World Health Organization (WHO) guideline states that the total
arsenic concentration in drinking water must not exceed 10 ppb. However,
arsenic toxicity varies significantly, with inorganic arsenic species
being more toxic than organic species. Arsenic speciation is therefore
important for evaluating the health risks from arsenic-contaminated
drinking water. Capillary electrophoresis provides the necessary high
performance separation to determine arsenic species in water, but its
sensitivity with absorbance detection is far below than needed. Using a
coated capillary, several on-line sample preconcentration techniques such
as large volume sample stacking with an electroosmotic flow pump, field
amplified sample injection (FASI), transient isotachophoresis (tITP),
electrokinetic supercharging (EKS) combining FASI and tITP, and counter
flow (CF)-EKS, were therefore investigated. With CF-EKS using phosphate
and N-cyclohexyl-2-aminoethanesulfonate as leading and terminating
electrolytes, respectively, standard samples of arsenite, arsenate,
monomethylarsonic acid, and dimethylarsinic acid were preconcentrated from
6,300- to 45,000-fold. The limits of detection obtained with UV absorbance
detection were 0.08-0.3 ppb As. For a spring water sample spiked with the
four arsenic species, LODs of 2-9 ppb As were obtained, which are lower
than the WHO guideline of 10 ppb total As.
KW - Arsenic speciation
KW - Capillary electrophoresis
KW - Counter flow electrokinetic supercharging
KW - Isotachophoresis
KW - Sample stacking technique
LA - eng
IS - 1873-3573 (Electronic)
PT - Journal Article
TA - Talanta
YR - 2018
DATE- 20180328
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Talanta
EDAT- 20180203
STAT- PubMed-not-MEDLINE
DOCNO- medline/29426526

52 - TOXLINE
TI - Maternal arsenic exposure and birth outcomes: A birth cohort study in
Wuhan, China.
AU - Liu H
AD - Key Laboratory of Environment and Health (HUST), Ministry of Education &amp;
Ministry of Environmental Protection, State Key Laboratory of Environmental Health,
School of Public Health, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan, Hubei, China.
AU - Lu S
AD - Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan, China.
AU - Zhang B
AD - Wuhan Medical and Health Center for Women and Children, Wuhan, Hubei, China.
AU - Xia W
AD - Key Laboratory of Environment and Health (HUST), Ministry of Education &amp;
Ministry of Environmental Protection, State Key Laboratory of Environmental Health,
School of Public Health, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan, Hubei, China.
AU - Liu W
AD - Key Laboratory of Environment and Health (HUST), Ministry of Education &amp;
Ministry of Environmental Protection, State Key Laboratory of Environmental Health,
School of Public Health, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan, Hubei, China.
AU - Peng Y
AD - Key Laboratory of Environment and Health (HUST), Ministry of Education &amp;
Ministry of Environmental Protection, State Key Laboratory of Environmental Health,
School of Public Health, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan, Hubei, China.
AU - Zhang H
AD - Wuhan Polytechnic University, Wuhan, Hubei, China.
AU - Wu K
AD - Department of Chemistry, Huazhong University of Science and Technology,
Wuhan, China.
AU - Xu S
AD - Key Laboratory of Environment and Health (HUST), Ministry of Education &amp;
Ministry of Environmental Protection, State Key Laboratory of Environmental Health,
School of Public Health, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan, Hubei, China.
AU - Li Y
AD - Key Laboratory of Environment and Health (HUST), Ministry of Education &amp;
Ministry of Environmental Protection, State Key Laboratory of Environmental Health,
School of Public Health, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan, Hubei, China. Electronic address: liyuanyuan@hust.edu.cn.
SO - Environ Pollut. 2018, May; 236:817-823. [Environmental pollution (Barking,
Essex : 1987)]
AB - Maternal arsenic exposure leads to adverse birth outcomes, but the
critical window of this susceptibility keeps unclear. To determine whether
the associations between maternal arsenic exposure and birth outcomes were
trimester-specific, we conducted a birth cohort study of 1390 women from
2014 to 2016 in Wuhan, China. We examined associations between total
urinary arsenic concentrations in three trimesters and birth weight, birth
length and the risk of small for gestational age (SGA), and the
differences of these associations across trimesters using generalized
estimating equations. Maternal urinary arsenic concentrations varied
across trimesters and were weakly correlated. Arsenic concentrations in
the 3rd trimester, but not in the 1st and 2nd trimesters, were associated
with birth outcomes. For each doubling of arsenic levels in the 3rd
trimester, birth weight was decreased 24.27&#8239;g (95% confidence
interval (CI): -46.99, -1.55), birth length was decreased
0.13&#8239;cm (95% CI: -0.22, -0.04), and the risk for SGA birth
was increased 25% (95% CI: 1.03, 1.49). Further, stratified analyses
indicated that these associations were only observed in female infants.
Our findings indicate maternal arsenic levels in the 3rd trimester seemed
to have significant impacts on birth outcomes, and also emphasize the
public health interventions relevance to arsenic exposure in late
pregnancy.
KW - Cohort
KW - Critical window
KW - Low-level arsenic
KW - Sex specific
KW - Urine
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180615
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
STAT- MEDLINE
DOCNO- medline/29462776

53 - TOXLINE
TI - Embryonic-only arsenic exposure alters skeletal muscle satellite cell
function in killifish (Fundulus heteroclitus).
AU - Szymkowicz DB
AD - Environmental Toxicology Graduate Program, Clemson University, Clemson, SC,
United States.
AU - Schwendinger KL
AD - Department of Biological Sciences, Clemson University, Clemson, SC, United
States.
AU - Tatnall CM
AD - Department of Biological Sciences, Clemson University, Clemson, SC, United
States.
AU - Swetenburg JR
AD - Department of Biological Sciences, Clemson University, Clemson, SC, United
States.
AU - Bain LJ
AD - Environmental Toxicology Graduate Program, Clemson University, Clemson, SC,
United States; Department of Biological Sciences, Clemson University, Clemson, SC,
United States. Electronic address: lbain@clemson.edu.
SO - Aquat Toxicol. 2018, May; 198:276-286. [Aquatic toxicology (Amsterdam,
Netherlands)]
AB - Arsenic is a contaminant found worldwide in drinking water and food.
Epidemiological studies have correlated arsenic exposure with reduced
weight gain and improper muscular development, while in vitro studies show
that arsenic exposure impairs myogenic differentiation. The purpose of
this study was to use Fundulus heteroclitus or killifish as a model
organism to determine if embryonic-only arsenic exposure permanently
reduces the number or function of muscle satellite cells. Killifish
embryos were exposed to 0, 50, 200, or 800&#8239;ppb arsenite (AsIII)
until hatching, and then juvenile fish were raised in clean water. At 28,
40, and 52 weeks after hatching, skeletal muscle injuries were induced by
injecting cardiotoxin into the trunk of the fish just posterior to the
dorsal fin. Muscle sections were collected at 0, 3 and 10&#8239;days
post-injury. Collagen levels were used to assess muscle tissue damage and
recovery, while levels of proliferating cell nuclear antigen (PCNA) and
myogenin were quantified to compare proliferating cells and newly formed
myoblasts. At 28 weeks of age, baseline collagen levels were 105% and 112%
greater in 200 and 800&#8239;ppb groups, respectively, and at 52 weeks of
age, were 58% higher than controls in the 200&#8239;ppb fish. After
cardiotoxin injury, collagen levels tend to increase to a greater extent
and take longer to resolve in the arsenic exposed fish. The number of
baseline PCNA(+) cells were 48-216% greater in 800&#8239;ppb exposed fish
compared to controls, depending on the week examined. However, following
cardiotoxin injury, PCNA is reduced at 28 weeks in 200 and 800&#8239;ppb
fish at day 3 during the recovery period. By 52 weeks, there are
significant reductions in PCNA in all exposure groups at day 3 of the
recovery period. Based on these results, embryonic arsenic exposure
increases baseline collagen levels and PCNA(+) cells in skeletal muscle.
However, when these fish are challenged with a muscle injury, the
proliferation and differentiation of satellite cells into myogenic
precursors is impaired and instead, the fish appear to be favoring a
fibrotic resolution to the injury.
KW - Arsenic
KW - Collagen
KW - Embryo
KW - Fish
KW - Myogenin
KW - Satellite cell
RN - 9007-34-5
RN - N5509X556J
RN - N712M78A8G
LA - eng
IS - 1879-1514 (Electronic)
PT - Journal Article
TA - Aquat Toxicol
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Aquatic toxicology (Amsterdam, Netherlands)
EDAT- 20180319
STAT- MEDLINE
CM - Cites: PLoS One. 2012;7(5):e38249 (medline /22693606)
CM - Cites: Toxicol Sci. 2012 Sep;129(1):146-56 (medline /22641621)
CM - Cites: Nat Commun. 2013;4:1964 (medline /23743995)
CM - Cites: Toxicol Lett. 2002 Jul 7;133(1):1-16 (medline /12076506)
CM - Cites: Aquat Toxicol. 2017 May;186:1-10 (medline /28237603)
CM - Cites: Environ Int. 2009 May;35(4):743-59 (medline /19232730)
CM - Cites: J Prev Med Public Health. 2014 Sep;47(5):245-52 (medline /25284195)
CM - Cites: Cold Spring Harb Perspect Biol. 2012 Feb 01;4(2):null (medline
/22300977)
CM - Cites: Am J Epidemiol. 2009 Feb 1;169(3):304-12 (medline /19037006)
CM - Cites: Postgrad Med J. 2003 Jul;79(933):391-6 (medline /12897217)
CM - Cites: PLoS One. 2015 Sep 11;10(9):e0137907 (medline /26359868)
CM - Cites: Trends Cell Biol. 2016 Jun;26(6):434-444 (medline /26948993)
CM - Cites: Ecotoxicol Environ Saf. 2015 Feb;112:247-70 (medline /25463877)
CM - Cites: J Cell Sci. 2014 Nov 1;127(Pt 21):4543-8 (medline /25300792)
CM - Cites: Am J Physiol Regul Integr Comp Physiol. 2010 May;298(5):R1173-87
(medline /20219869)
CM - Cites: Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5246-52 (medline
/26372956)
CM - Cites: Talanta. 2002 Aug 16;58(1):201-35 (medline /18968746)
CM - Cites: Gen Comp Endocrinol. 2013 Oct 1;192:136-48 (medline /23791761)
CM - Cites: Aquat Toxicol. 2014 Jan;146:196-204 (medline /24316437)
CM - Cites: Compr Physiol. 2015 Jul 1;5(3):1027-59 (medline /26140708)
CM - Cites: J Exp Biol. 2006 Jun;209(Pt 12):2249-64 (medline /16731802)
CM - Cites: Epidemiology. 2016 Mar;27(2):173-81 (medline /26583609)
CM - Cites: Ann Anat. 2015 Nov;202:18-27 (medline /26340019)
CM - Cites: Int J Biochem Cell Biol. 2004 Jun;36(6):1031-7 (medline /15094118)
CM - Cites: J Expo Sci Environ Epidemiol. 2015 Nov-Dec;25(6):599-603 (medline
/25805251)
CM - Cites: Environ Health Perspect. 2010 Jul;118(7):949-56 (medline /20299303)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2006;41(10):2399-428 (medline /17018421)
CM - Cites: Free Radic Biol Med. 2014 Sep;74:64-73 (medline /24960579)
CM - Cites: J Exp Biol. 2011 May 15;214(Pt 10):1617-28 (medline /21525308)
CM - Cites: Chemosphere. 2003 Sep;52(9):1353-9 (medline /12867164)
CM - Cites: J Cell Sci. 2015 Oct 1;128(19):3525-31 (medline /26377767)
CM - Cites: Toxicol Sci. 2012 Feb;125(2):522-31 (medline /22058191)
CM - Cites: Environ Res. 2017 Aug;157:52-59 (medline /28521257)
CM - Cites: Stem Cells. 2016 Mar;34(3):732-42 (medline /26537186)
CM - Cites: PLoS One. 2016 Jan 25;11(1):e0147198 (medline /26807982)
CM - Cites: Environ Health Perspect. 2016 Aug;124(8):1308-15 (medline
/26859631)
CM - Cites: Toxicon. 2003 Dec 15;42(8):933-45 (medline /15019492)
CM - Cites: Adv Drug Deliv Rev. 2017 Nov 1;121:43-56 (medline /28736303)
DOCNO- medline/29574248

54 - TOXLINE
TI - Arsenic-containing hydrocarbons disrupt a model in vitro
blood-cerebrospinal fluid barrier.
AU - M�ller SM
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558 Nuthetal, Germany; Heinrich-Stockmeyer Foundation,
Parkstra&szlig;e 44-46, 49214 Bad Rothenfelde, Germany.
AU - Ebert F
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558 Nuthetal, Germany.
AU - Bornhorst J
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558 Nuthetal, Germany.
AU - Galla HJ
AD - Institute of Biochemistry, University of M�nster, Wilhelm-Klemm-Str. 2, 48149
M�nster, Germany.
AU - Francesconi KA
AD - Institute of Chemistry, NAWI Graz, University of Graz, Universit�tsplatz 1,
8010 Graz, Austria.
AU - Schwerdtle T
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558 Nuthetal, Germany. Electronic address: tanja.schwerdtle@uni-
potsdam.de.
SO - J Trace Elem Med Biol. 2018, Sep; 49:171-177. [Journal of trace elements
in medicine and biology : organ of the Society for Minerals and Trace
Elements (GMS)]
AB - Lipid-soluble arsenicals, so-called arsenolipids, have gained a lot of
attention in the last few years because of their presence in many seafoods
and reports showing substantial cytotoxicity emanating from
arsenic-containing hydrocarbons (AsHCs), a prominent subgroup of the
arsenolipids. More recent in vivo and in vitro studies indicate that some
arsenolipids might have adverse effects on brain health. In the present
study, we focused on the effects of selected arsenolipids and three
representative metabolites on the blood-cerebrospinal fluid barrier
(B-CSF-B), a brain-regulating interface. For this purpose, we incubated an
in vitro model of the B-CSF-B composed of porcine choroid plexus
epithelial cells (PCPECs) with three AsHCs, two arsenic-containing fatty
acids (AsFAs) and three representative arsenolipid metabolites
(dimethylarsinic acid, thio/oxo-dimethylpropanoic acid) to examine their
cytotoxic potential and impact on barrier integrity. The toxic arsenic
species arsenite was also tested in this way and served as a reference
substance. While AsFAs and the metabolites showed no cytotoxic effects in
the conducted assays, AsHCs showed a strong cytotoxicity, being up to
1.5-fold more cytotoxic than arsenite. Analysis of the in vitro B-CSF-B
integrity showed a concentration-dependent disruption of the barrier
within 72&#8239;h. The correlation with the decreased plasma membrane
surface area (measured as capacitance) indicates cytotoxic effects. These
findings suggest exposure to elevated levels of certain arsenolipids may
have detrimental consequences for the central nervous system.
KW - Arsenic-containing fatty acids
KW - Arsenic-containing hydrocarbons
KW - Arsenolipids
KW - Blood-cerebrospinal fluid barrier
KW - Blood-liquor barrier
LA - eng
IS - 1878-3252 (Electronic)
PT - Journal Article
TA - J Trace Elem Med Biol
YR - 2018
DATE- 20180613
CI - Copyright &copy; 2018 Elsevier GmbH. All rights reserved.
CITO- NLM
CS - Germany
FJT - Journal of trace elements in medicine and biology : organ of the Society
for Minerals and Trace Elements (GMS)
EDAT- 20180206
STAT- In-Process
DOCNO- medline/29449109

55 - TOXLINE
TI - Species-specific bioaccumulation and correlated health risk of arsenic
compounds in freshwater fish from a typical mine-impacted river.
AU - Jia Y
AD - College of Chemistry and Chemical Engineering, Central South University,
Changsha 410083, China.
AU - Wang L
AD - College of Chemistry and Chemical Engineering, Central South University,
Changsha 410083, China; Hunan Provincial Key Laboratory of Efficient and Clean
Utilization of Manganese Resources, Central South University, Changsha 410083,
China. Electronic address: linwang@csu.edu.cn.
AU - Li S
AD - College of Chemistry and Chemical Engineering, Central South University,
Changsha 410083, China.
AU - Cao J
AD - College of Chemistry and Chemical Engineering, Central South University,
Changsha 410083, China.
AU - Yang Z
AD - College of Chemistry and Chemical Engineering, Central South University,
Changsha 410083, China; Hunan Provincial Key Laboratory of Efficient and Clean
Utilization of Manganese Resources, Central South University, Changsha 410083,
China; Center for Environment and Water Resources, Central South University,
Changsha 410083, China. Electronic address: zgyang@csu.edu.cn.
SO - Sci Total Environ. 2018, Jun 01; 625:600-607. [The Science of the total
environment]
AB - Arsenic (As) speciation and bioaccumulation in fish muscle tissues have
been intensively investigated in marine ecosystem. However, little is
known about these in freshwater fish. In this study, freshwater fish
including 120 specimens and 8 species were collected from the Xiang River,
a typical mine-impacted river in China. Six As species including arsenite
(AsIII), arsenate (AsV), monomethylarsonic acid (MMA), dimethylarsinic
acid (DMA), arsenocholine (AsC) and arsenobetaine (AsB) were
simultaneously separated and determined using HPLC-ICP-MS. The mean
(&plusmn;SD) concentration of total As (tAs) in the dried fish muscle was
0.748&plusmn;0.651mg&middot;kg-1. AsB was found as the predominant As
species in most of the studied fish samples, in accordance with the
reports in marine fish. However, the diversity of inorganic/organic As
proportion observed in the studied freshwater fish species was larger than
that in marine fish species due to greater spatial variability of As
contamination, mobilization and origination in the studied catchments. The
percentage of AsB (AsB%) in fish muscle was irrelevant to tAs
concentration, while the percentage of iAs (iAs%) decreased with tAs
concentration in a hyperbolic pattern. This can be attributed to
restricted assimilation and accumulation of toxic iAs with increasing tAs
concentration in fish. Chronic non-carcinogenic and carcinogenic health
risks were evaluated through Monte-Carlo simulation. The result indicated
that consuming freshwater fish in the Xiang River could cause considerable
carcinogenic risk to local inhabitants.
KW - Arsenic
KW - Arsenobetaine
KW - Fish
KW - Inorganic arsenic
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180227
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20171230
STAT- In-Process
DOCNO- medline/29294442

56 - TOXLINE
TI - Prenatal arsenic exposure, child marriage, and pregnancy weight gain:
Associations with preterm birth in Bangladesh.
AU - Rahman ML
AD - Harvard T.H. Chan School of Public Health, Department of Environmental
Health, Boston, MA, USA.
AU - Kile ML
AD - Oregon State University, College of Public Health and Human Sciences,
Corvallis, OR, USA.
AU - Rodrigues EG
AD - Harvard T.H. Chan School of Public Health, Department of Environmental
Health, Boston, MA, USA.
AU - Valeri L
AD - McLean Hospital, Belmont, Massachusetts, USA and Harvard Medical School,
Boston, MA, USA.
AU - Raj A
AD - Center on Gender Equity and Health, Department of Medicine, University of
California, San Diego, CA, USA.
AU - Mazumdar M
AD - Harvard T.H. Chan School of Public Health, Department of Environmental
Health, Boston, MA, USA.
AU - Mostofa G
AD - Dhaka Community Hospital Trust, Dhaka, Bangladesh.
AU - Quamruzzaman Q
AD - Dhaka Community Hospital Trust, Dhaka, Bangladesh.
AU - Rahman M
AD - Dhaka Community Hospital Trust, Dhaka, Bangladesh.
AU - Hauser R
AD - Harvard T.H. Chan School of Public Health, Department of Environmental
Health, Boston, MA, USA; Harvard T.H. Chan School of Public Health, Department of
Epidemiology, Boston, MA, USA.
AU - Baccarelli A
AD - Columbia University, Mailman School of Public Health, Department of
Environmental Health, New York, NY, USA.
AU - Liang L
AD - Harvard T.H. Chan School of Public Health, Department of Biostatistics,
Boston, MA, USA.
AU - Christiani DC
AD - Harvard T.H. Chan School of Public Health, Department of Environmental
Health, Boston, MA, USA; Harvard T.H. Chan School of Public Health, Department of
Epidemiology, Boston, MA, USA. Electronic address: dchris@hsph.harvard.edu.
SO - Environ Int. 2018, Mar; 112:23-32. [Environment international]
AB - BACKGROUND: Preterm birth is a disease of multifactorial etiologies that
has environmental, social, and maternal health components. Individual
studies have shown that exposure to arsenic contaminated drinking water,
child marriage, and low maternal weight gain during pregnancy contribute
to preterm birth. These factors are highly prevalent and often co-exist in
Bangladesh, a country in South Asia with one of the world's highest
prevalences of preterm birth.
AB - OBJECTIVE: To evaluate the individual and interactive effects of prenatal
arsenic exposure, child marriage, and pregnancy weight gain on preterm
birth in a prospective birth cohort in Bangladesh.
AB - METHODS: During 2008-2011, we recruited 1613 pregnant women aged
&ge;18years at &le;16weeks of gestation and followed them until 1-month
post-partum. We measured total arsenic in drinking water (n=1184) and in
maternal toenails (n=1115) collected at enrollment and &le;1-month
post-partum, respectively using inductively coupled plasma mass
spectrometry. Child marriage ( < 18years old) was defined using
self-report, and 2nd and 3rd trimester pregnancy weight gain was
calculated using monthly records. Gestational age was determined at
enrollment by ultrasound.
AB - RESULTS: In multivariate adjusted Poisson regression models, the risk
ratios (RR) for preterm birth were 1.12 (95% CI: 1.07-1.18) for a unit
change in natural log water arsenic exposure, 2.28 (95% CI: 1.76-2.95) for
child marriage, and 0.64 (95% CI: 0.42-0.97) for a pound per week increase
in maternal weight during the 2nd and 3rd trimesters. In stratified
analysis by child marriage, pregnancy weight gain was inversely associated
with preterm birth among women with a history of child marriage (RR=0.58;
95% CI: 0.37-0.92), but not among women with no history of child marriage
(RR=86; 95% CI: 0.37-2.01). Mediation analysis revealed that both arsenic
exposure and child marriage had small but significant associations with
preterm birth via lowering pregnancy weight gain. Similar associations
were observed when arsenic exposure was assessed using maternal toenail
arsenic concentrations.
AB - CONCLUSIONS: Reducing arsenic exposure and ending child marriage could
reduce the risk of preterm birth in Bangladesh. Furthermore, enhancing
nutritional support to ensure adequate weight gain during pregnancy may
provide additional benefits especially for women with a history of child
marriage.
LA - eng
IS - 1873-6750 (Electronic)
PT - Journal Article
TA - Environ Int
YR - 2018
DATE- 20180413
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Environment international
EDAT- 20171212
STAT- In-Data-Review
DOCNO- medline/29245039

57 - TOXLINE
TI - Statistical optimization of arsenic biosorption by microbial enzyme via
Ca-alginate beads.
AU - Banerjee S
AD - a Department of Polymer Science and technology , Biosensor Laboratory,
University of Calcutta , Kolkata , West Bengal , India.
AU - Banerjee A
AD - a Department of Polymer Science and technology , Biosensor Laboratory,
University of Calcutta , Kolkata , West Bengal , India.
AU - Sarkar P
AD - a Department of Polymer Science and technology , Biosensor Laboratory,
University of Calcutta , Kolkata , West Bengal , India.
SO - J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018, Apr 16;
53(5):436-442. [Journal of environmental science and health. Part A,
Toxic/hazardous substances & environmental engineering]
AB - Bioremediation of arsenic using green technology via microbial enzymes has
attracted scientists due to its simplicity and cost effectiveness.
Statistical optimization of arsenate bioremediation was conducted by the
enzyme arsenate reductase extracted from arsenic tolerant bacterium
Pseudomonas alcaligenes. Response surface methodology based on Box-Behnken
design matrix was performed to determine the optimal operational
conditions of a multivariable system and their interactive effects on the
bioremediation process. The highest biosorptive activity of
96.2 &micro;g gm-1 of beads was achieved under optimized conditions
(pH = 7.0; As (V) concentration = 1000 ppb; time = 2 h). SEM
analysis showed the morphological changes on the surface of enzyme
immobilized gluteraldehyde crosslinked Ca-alginate beads. The immobilized
enzyme retained its activity for 8 cycles. ANOVA with a high correlation
coefficient (R2 > 0.99) and lower "Prob > F"value ( < 0.0001)
corroborated the second-order polynomial model for the biosorption
process. This study on the adsorptive removal of As (V) by enzyme-loaded
biosorbent revealed a possible way of its application in large scale
treatment of As (V)-contaminated water bodies.
KW - Arsenate
KW - arsenate reductase
KW - biosorption
KW - box–behnken design
KW - response surface methodology
KW - statistical optimization
RN - 8A5D83Q4RW
RN - 8C3Z4148WZ
RN - N712M78A8G
RN - N7CIZ75ZPN
RN - SY7Q814VUP
LA - eng
IS - 1532-4117 (Electronic)
PT - Journal Article
TA - J Environ Sci Health A Tox Hazard Subst Environ Eng
YR - 2018
DATE- 20180525
CITO- NLM
CS - England
CSET- IM
FJT - Journal of environmental science and health. Part A, Toxic/hazardous
substances &amp; environmental engineering
EDAT- 20171226
STAT- MEDLINE
DOCNO- medline/29278978

58 - TOXLINE
TI - Taxonomically-linked growth phenotypes during arsenic stress among arsenic
resistant bacteria isolated from soils overlying the Centralia coal seam
fire.
AU - Dunivin TK
AD - Environmental and Integrative Toxicological Sciences Doctoral Program,
Michigan State University, East Lansing, Michigan, United States of America.
AU - Miller J
AD - Lyman Briggs College, Michigan State University, East Lansing, Michigan,
United States of America.
AU - Shade A
AD - Program in Ecology, Evolutionary Biology and Behavior, Michigan State
University, East Lansing, Michigan, United States of America.
SO - PLoS One. 2018; 13(1):e0191893. [PloS one]
AB - Arsenic (As), a toxic element, has impacted life since early Earth. Thus,
microorganisms have evolved many As resistance and tolerance mechanisms to
improve their survival outcomes given As exposure. We isolated As
resistant bacteria from Centralia, PA, the site of an underground coal
seam fire that has been burning since 1962. From a 57.4&deg;C soil
collected from a vent above the fire, we isolated 25 unique aerobic As
resistant bacterial strains spanning seven genera. We examined their
diversity, resistance gene content, transformation abilities, inhibitory
concentrations, and growth phenotypes. Although As concentrations were low
at the time of soil collection (2.58 ppm), isolates had high minimum
inhibitory concentrations (MICs) of arsenate and arsenite ( > 300 mM and
20 mM respectively), and most isolates were capable of arsenate reduction.
We screened isolates (PCR and sequencing) using 12 published primer sets
for six As resistance genes (AsRGs). Genes encoding arsenate reductase
(arsC) and arsenite efflux pumps (arsB, ACR3(2)) were present, and
phylogenetic incongruence between 16S rRNA genes and AsRGs provided
evidence for horizontal gene transfer. A detailed investigation of
differences in isolate growth phenotypes across As concentrations (lag
time to exponential growth, maximum growth rate, and maximum OD590) showed
a relationship with taxonomy, providing information that could help to
predict an isolate's performance given As exposure in situ. Our results
suggest that microbiological management and remediation of environmental
As could be informed by taxonomically-linked As tolerance, potential for
resistance gene transferability, and the rare biosphere.
RN - N712M78A8G
LA - eng
IS - 1932-6203 (Electronic)
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
TA - PLoS One
YR - 2018
DATE- 20180312
CITO- NLM
CS - United States
CSET- IM
FJT - PloS one
EDAT- 20180125
STAT- MEDLINE
CM - Cites: FEMS Microbiol Lett. 2004 Aug 15;237(2):249-53 (medline /15321669)
CM - Cites: Appl Microbiol Biotechnol. 2013 Jan;97(1):51-62 (medline /23138712)
CM - Cites: Environ Geochem Health. 2010 Apr;32(2):95-105 (medline /19548094)
CM - Cites: Appl Environ Microbiol. 2010 Apr;76(8):2445-50 (medline /20173072)
CM - Cites: Ecotoxicology. 2013 Mar;22(2):363-76 (medline /23238642)
CM - Cites: Can J Microbiol. 1978 Dec;24(12):1468-74 (medline /747810)
CM - Cites: Nat Rev Microbiol. 2016 Apr;14 (5):320-30 (medline /27080241)
CM - Cites: Annu Rev Microbiol. 2017 Sep 8;71:711-730 (medline /28731846)
CM - Cites: Appl Environ Microbiol. 2011 Jul;77(13):4685-92 (medline /21571879)
CM - Cites: BMC Genomics. 2008 Mar 24;9:136 (medline /18366724)
CM - Cites: BMC Evol Biol. 2003 Jul 23;3:18 (medline /12877744)
CM - Cites: Curr Microbiol. 2004 May;48(5):341-7 (medline /15060729)
CM - Cites: Naturwissenschaften. 2003 Sep;90(9):395-401 (medline /14504781)
CM - Cites: J Microbiol Methods. 2004 Sep;58(3):335-49 (medline /15279938)
CM - Cites: Chemosphere. 2011 Sep;85(1):129-34 (medline /21724233)
CM - Cites: Appl Environ Microbiol. 2008 Jul;74(14):4567-73 (medline /18502920)
CM - Cites: Appl Microbiol Biotechnol. 2008 Aug;80(1):155-65 (medline
/18560832)
CM - Cites: Environ Pollut. 2008 Dec;156(3):1069-74 (medline /18550235)
CM - Cites: Front Microbiol. 2016 May 02;7:636 (medline /27199962)
CM - Cites: Environ Sci Technol. 2004 Jan 1;38(1):104-11 (medline /14740724)
CM - Cites: Appl Environ Microbiol. 2007 Aug;73(16):5261-7 (medline /17586664)
CM - Cites: Can J Microbiol. 2010 Mar;56(3):236-46 (medline /20453910)
CM - Cites: Syst Appl Microbiol. 2010 Apr;33(3):154-64 (medline /20303688)
CM - Cites: Mol Biol Evol. 2016 Jul;33(7):1870-4 (medline /27004904)
CM - Cites: Nucleic Acids Res. 2014 Jan;42(Database issue):D633-42 (medline
/24288368)
CM -Cites: FEMS Microbiol Ecol. 2009 Apr;68(1):108-17 (medline /19291024)
CM -Cites: J Microbiol Methods. 2003 Dec;55(3):541-55 (medline /14607398)
CM -Cites: Environ Microbiol. 2012 Sep;14(9):2247-52 (medline /22788977)
CM -Cites: Nat Methods. 2012 Jun 28;9(7):676-82 (medline /22743772)
CM -Cites: J Bacteriol. 2005 Jul;187(14):4853-64 (medline /15995200)
CM -Cites: FEMS Microbiol Rev. 2016 Mar;40(2):299-322 (medline /26790947)
CM -Cites: Int J Syst Evol Microbiol. 2012 Mar;62(Pt 3):716-21 (medline
/22140171)
CM - Cites: BMC Microbiol. 2009 Jan 08;9:4 (medline /19128515)
CM - Cites: Folia Microbiol (Praha). 2011 Jan;56(1):29-35 (medline /21394480)
CM - Cites: J Biol Methods. 2014;1(2):null (medline /25606571)
CM - Cites: J Antibiot (Tokyo). 2010 Aug;63(8):468-76 (medline /20648021)
CM - Cites: Sci Total Environ. 2016 Aug 15;562:588-595 (medline /27110973)
CM - Cites: J Hazard Mater. 2014 May 15;272:112-20 (medline /24685527)
CM - Cites: Appl Environ Microbiol. 2016 Nov 21;82(24):7019-7029 (medline
/27663031)
CM - Cites: ISME J. 2017 Jun;11(6):1447-1459 (medline /28282042)
CM - Cites: Syst Appl Microbiol. 2005 Oct;28(8):727-34 (medline /16261862)
CM - Cites: Appl Environ Microbiol. 2006 May;72(5):3738-42 (medline /16672525)
CM - Cites: J Appl Microbiol. 2007 Dec;103(6):2299-308 (medline /18045414)
CM - Cites: Nat Rev Microbiol. 2005 May;3(5):439-46 (medline /15864265)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2011;46(14):1736-47 (medline /22175878)
CM - Cites: Environ Sci Technol. 2013 Apr 2;47(7):3141-8 (medline /23469919)
CM - Cites: Genome Res. 1999 Sep;9(9):868-77 (medline /10508846)
CM - Cites: FEMS Microbiol Rev. 2002 Aug;26(3):311-25 (medline /12165430)
CM - Cites: Res Microbiol. 2007 Mar;158(2):128-37 (medline /17258434)
CM - Cites: Int J Syst Evol Microbiol. 2004 Jul;54(Pt 4):1369-75 (medline
/15280316)
CM - Cites: Extremophiles. 2013 May;17(3):421-31 (medline /23525943)
DOCNO- medline/29370270

59 - TOXLINE
TI - &alpha;-Lipoic acid inhibits testicular and epididymal oxidative damage
and improves fertility efficacy in arsenic-intoxicated rats.
AU - Prathima P
AD - Department of Biotechnology, Vikrama Simhapuri University, Nellore, AP
524003, India.
AU - Pavani R
AD - Department of Biotechnology, Vikrama Simhapuri University, Nellore, AP
524003, India.
AU - Sukeerthi S
AD - Department of Biotechnology, Vikrama Simhapuri University, Nellore, AP
524003, India.
AU - Sainath SB
AD - Department of Biotechnology, Vikrama Simhapuri University, Nellore, AP
524003, India.
SO - J Biochem Mol Toxicol. 2018, Feb. [Journal of biochemical and molecular
toxicology]
AB - The present study evaluates the protective effect of &alpha;-lipoic acid
(LA) against arsenic-induced testicular and epididymal oxidative damage in
rats. Arsenic caused significant reduction in the reproductive organ
weights, serum testosterone levels, testicular daily sperm count,
epididymal sperm count, sperm motility, sperm viability, and sperm
membrane integrity. Significant reduction in the activity levels of
superoxide dismutase, catalase, and glutathione levels with a concomitant
increase in the lipid peroxidation and protein carbonyl content in the
testis and the cauda epididymis of arsenic-exposed rats. Arsenic
intoxication also enhanced the testicular caspase-3 mRNA levels,
disorganization of testicular and cauda epididymal architecture as well as
increased arsenic content in the testis and the cauda epididymis of rats.
Arsenic exposure also deteriorated fertility ability in male rats over
controls. Conversely, &alpha;-LA negated the testicular and cauda
epididymal oxidative stress and restored the male reproductive health in
arsenic-exposed rats.
KW - arsenic
KW - lipoic acid
KW - rats
KW - spermatogenesis
KW - testicular steroidogenesis
RN - 3XMK78S47O
RN - 48OVY2OC72
RN - 73Y7P0K73Y
RN - EC 1.-
RN - GAN16C9B8O
LA - eng
IS - 1099-0461 (Electronic)
PT - Journal Article
TA - J Biochem Mol Toxicol
YR - 2018
DATE- 20180618
CI - &copy; 2017 Wiley Periodicals, Inc.
CITO- NLM
CS - United States
CSET- IM
FJT - Journal of biochemical and molecular toxicology
EDAT- 20171207
STAT- MEDLINE
DOCNO- medline/29214690

60 - TOXLINE
TI - Lithium Treatment Aggregates the Adverse Effects on Erythrocytes Subjected
to Arsenic Exposure.
AU - Bhardwaj P
AD - Department of Biophysics, Panjab University Chandigarh, Chandigarh, 160014,
India.
AU - Jain K
AD - Centre of Nuclear Medicine, Panjab University Chandigarh, Chandigarh, India.
AU - Dhawan DK
AD - Department of Biophysics, Panjab University Chandigarh, Chandigarh, 160014,
India. dhawan@pu.ac.in.
SO - Biol Trace Elem Res. 2018, Jul; 184(1):206-213. [Biological trace element
research]
AB - The present study was designed to investigate the effects of lithium
treatment on red blood cells which were given arsenic exposure. Long-term
lithium therapy is being extensively used for the treatment of bipolar
disorders. Arsenic is a group I carcinogen and a major toxic pollutant in
drinking water that affects millions of people worldwide. Male SD rats
were segregated into four groups, viz. normal control, lithium treated,
arsenic treated, and lithium + arsenic treated. Lithium was supplemented
as lithium carbonate at a dose level of 1.1 g/kg diet for a period of
8 weeks. Arsenic was given in the form of sodium arsenite at a dose
level of 100 ppm in drinking water, ad libitum, for the same period.
Lysates of red blood cells were used to investigate the effects of lithium
and arsenic treatments on anti-oxidant enzymes, reduced glutathione (GSH),
and lipid peroxidation (LPO) levels. Various hematological parameters,
activities of Na+ K+ ATPase and delta-aminolevulinic acid dehydratase
(&delta;-ALAD) were also assessed. A significant reduction was observed in
the activities of antioxidant enzymes, GSH levels, total erythrocyte
counts, Na+ K+ ATPase, and ALAD enzyme activities in lysates of red blood
cells when exposed either to lithium or arsenic. In addition, a
significant increase in the levels of malondialdehyde (MDA), lymphocytes,
neutrophils, and total leukocytes was also observed following lithium as
well as arsenic treatments. However, when arsenic-treated rats were
subjected to lithium treatment, a pronounced alteration was noticed in all
the above parameters. Therefore, we conclude that lithium supplementation
to the arsenic-treated rats enhances the adverse effects on red blood
cells and therefore use of lithium may not be medicated to patients who
are vulnerable to arsenic exposure through drinking water. It can also be
inferred that adverse effects of lithium therapy may get aggravated in
patients thriving in the arsenic-contaminated area.
KW - Arsenic
KW - Lithium therapy
KW - Oxidative stress
KW - Red blood cell lysates
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180608
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20171007
STAT- In-Process
DOCNO- medline/28988373

61 - TOXLINE
TI - Chronic exposure to arsenic and high fat diet additively induced
cardiotoxicity in male mice.
AU - Ahangarpour A
AD - Health Research Institute, Diabetes Research Center, Department of
Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran.
AU - Zeidooni L
AD - Department of Toxicology and Student Research Committee, School of Pharmacy,
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran.
AU - Samimi A
AD - Department of Toxicology and Student Research Committee, School of Pharmacy,
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran.
AU - Alboghobeish S
AD - Department of Pharmacology and Student Research Committee, School of
Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran.
AU - Khorsandi LS
AD - Cell and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur
University of Medical Sciences, Ahvaz, I.R. Iran.
AU - Moradi M
AD - Health Research Institute, Diabetes Research Center, Department of
Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I.R. Iran.
SO - Res Pharm Sci. 2018, Feb; 13(1):47-56. [Research in pharmaceutical
sciences]
AB - Diet is one of the important risk factors that could potentially affect
arsenic-induced cardiotoxicity. The present study was undertaken to
investigate the effect of high fat diet on arsenic-induced cardiotoxicity
in mice. Mice were divided into six different groups (n = 12), two control
groups received either low fat diet (LFD) or high fat diet (HFD) along
with deionized drinking water and four test groups given LFD + 25 ppm
arsenic, LFD + 50 ppm arsenic, HFD + 25 ppm arsenic, and HFD + 50 ppm
arsenic in drinking water for 5 months. The body weight, heart weight to
body weight ratio, cardiac biochemical markers, lipid profile, and
histological examination of heart were evaluated. The results demonstrated
that arsenic exposure led to a significant decrease in heart glutathione
level, catalase enzyme activity, and a significant increase in reactive
oxygen species (ROS), malondialdehyde levels, and biochemical enzymes. The
administration of HFD resulted in above-mentioned changes as well as an
alteration in lipid profile; however, arsenic exposure alone or along with
HFD caused a reduction in lipid profile factors, except HDL level. Our
results revealed that HFD increased arsenic-induced heart injury in the
mice. This effect may be because of reduction in antioxidant activities
and/or increase in oxidative stress and ROS in mice heart tissues. These
findings could be important for clinical intervention to protect against
or prevent arsenic-induced cardiotoxicity in humans.
KW - Arsenic
KW - Cardiotoxicity
KW - Chronic exposure
KW - Heart
KW - High fat diet
LA - eng
IS - 1735-5362 (Print)
PT - Journal Article
TA - Res Pharm Sci
YR - 2018
DATE- 20180204
CITO- NLM
CS - Iran
FJT - Research in pharmaceutical sciences
STAT- PubMed-not-MEDLINE
CM - Cites: Food Chem Toxicol. 2006 Sep;44(9):1579-84 (medline /16774805)
CM - Cites: Sci Rep. 2014 Nov 04;4:6894 (medline /25367288)
CM - Cites: Diabetol Metab Syndr. 2011 Dec 23;3(1):37 (medline /22196253)
CM - Cites: Toxicol Appl Pharmacol. 2007 Aug 1;222(3):315-26 (medline
/17433393)
CM - Cites: Arch Toxicol. 2008 Mar;82(3):137-49 (medline /18197399)
CM - Cites: Toxicol Sci. 2009 Feb;107(2):312-23 (medline /19015167)
CM - Cites: Ecotoxicol Environ Saf. 2011 May;74(4):607-14 (medline /20719385)
CM - Cites: Toxicol Lett. 2003 Jan 31;137(1-2):15-21 (medline /12505429)
CM - Cites: Food Chem Toxicol. 2014 Apr;66:262-77 (medline /24508525)
CM - Cites: Exp Biol Med (Maywood). 2008 Mar;233(3):377-84 (medline /18296743)
CM - Cites: Diabetol Metab Syndr. 2011 Aug 03;3(1):17 (medline /21812977)
CM - Cites: Hypertension. 1999 Jan;33(1):74-8 (medline /9931084)
CM - Cites: J Neurochem. 2005 Jun;93(6):1561-7 (medline /15935072)
CM - Cites: Chem Rev. 2011 Oct 12;111(10):5944-72 (medline /21861450)
CM - Cites: Med Clin North Am. 2011 Sep;95(5):919-37 (medline /21855700)
CM - Cites: Biol Trace Elem Res. 1995 Nov;50(2):119-24 (medline /8605079)
CM - Cites: Gastroenterol Hepatol Bed Bench. 2017 Winter;10 (1):44-53 (medline
/28331564)
CM - Cites: Mutagenesis. 1994 May;9(3):253-7 (medline /7934966)
CM - Cites: PLoS One. 2012;7(6):e38713 (medline /22719926)
CM - Cites: J Invest Dermatol. 1999 Nov;113(5):760-5 (medline /10571731)
CM - Cites: Curr Vasc Pharmacol. 2006 Jul;4(3):215-27 (medline /16842139)
CM - Cites: J Cell Physiol. 1998 Nov;177(2):324-33 (medline /9766529)
CM - Cites: Toxicol Appl Pharmacol. 2009 Sep 15;239(3):320-4 (medline
/19573547)
CM - Cites: Biochim Biophys Acta. 1998 Apr 29;1397(2):223-30 (medline /9565690)
CM - Cites: Basic Clin Pharmacol Toxicol. 2006 Jan;98(1):38-43 (medline
/16433889)
CM -Cites: Indian J Med Res. 2008 Oct;128(4):501-23 (medline /19106443)
CM -Cites: Int J Epidemiol. 2001 Oct;30(5):983-8 (medline /11689508)
CM -Cites: J Proteome Res. 2014 Feb 7;13(2):547-554 (medline /24328084)
CM -Cites: Hypertension. 1995 Jan;25(1):53-60 (medline /7843753)
CM -Cites: Pathophysiology. 2008 Oct;15(3):147-56 (medline /18434106)
CM -Cites: J Radiat Res. 2008 Nov;49(6):579-86 (medline /18827438)
CM -Cites: Toxicol Appl Pharmacol. 2005 Aug 7;206(2):169-75 (medline
/15967205)
CM - Cites: Neurotoxicology. 2003 Aug;24(4-5):747-53 (medline /12900089)
CM - Cites: Life Sci. 2005 Sep 16;77(18):2324-37 (medline /15964026)
CM - Cites: Cardiovasc Toxicol. 2002;2(1):63-73 (medline /12189281)
CM - Cites: Cardiovasc Toxicol. 2014 Mar;14 (1):83-97 (medline /24062023)
CM - Cites: Proc Natl Acad Sci U S A. 1984 Jul;81(14):4343-7 (medline /6589599)
CM - Cites: Environ Health Perspect. 2011 Aug;119(8):1104-9 (medline /21592922)
DOCNO- medline/29387111

62 - TOXLINE
TI - Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell
transformation.
AU - Chen QY
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Li J
AD - Hubei Province Key Laboratory of Occupational Hazard Identification and
Control, Medical college, Wuhan University of Science and Technology, Wuhan, China.
AU - Sun H
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Wu F
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Zhu Y
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Kluz T
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Jordan A
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - DesMarais T
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Zhang X
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Murphy A
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
AU - Costa M
AD - Department of Environmental Medicine, New York University School of Medicine,
New York, New York.
SO - Mol Carcinog. 2018, Mar 30. [Molecular carcinogenesis]
AB - Arsenic is a naturally occurring and highly potent metalloid known to
elicit serious public health concerns. Today, approximately 200 million
people around the globe are exposed to arsenic-contaminated drinking water
at levels greater than the World Health Organization's recommended limit
of 10 parts per billion. As a class I human carcinogen, arsenic exposure
is known to elicit various cancers, including lung, skin, liver, and
kidney. Current evidence suggests that arsenic is capable of inducing both
genotoxic and cytotoxic injury, as well as activating epigenetic pathways
to induce carcinogenesis. Our study identifies a novel pathway that is
implicated in arsenic-induced carcinogenesis. Arsenic down-regulated
miRNA-31 and the release of this inhibition caused overexpression of
special AT-rich sequence-binding protein 2 (SATB2). Arsenic is known to
disrupt miRNA expression, and here we report for the first time that
arsenic is capable of inhibiting miR-31 expression. As a direct downstream
target of miR-31, SATB2 is a prominent transcription factor, and nuclear
matrix binding protein implicated in many types of human diseases
including lung cancer. Results from this study show that arsenic induces
the overexpressing SATB2 by inhibiting miR-31 expression, which blocks the
translation of SATB2 mRNA, since levels of SATB2 mRNA remain the same but
protein levels decrease. Overexpression of SATB2 induces malignant
transformation of human bronchial epithelial (BEAS-2B) cells indicating
the importance of the expression of miR-31 in preventing carcinogenesis by
suppressing SATB2 protein levels.
KW - carcinogenesis
KW - human bronchial epithelial cells
KW - metals
KW - non-coding RNAs
LA - eng
IS - 1098-2744 (Electronic)
PT - Journal Article
TA - Mol Carcinog
YR - 2018
DATE- 20180417
CI - &copy; 2018 Wiley Periodicals, Inc.
CITO- NLM
CS - United States
FJT - Molecular carcinogenesis
EDAT- 20180330
STAT- Publisher
DOCNO- medline/29603397

63 - TOXLINE
TI - Serum folate and cobalamin levels and urinary dimethylarsinic acid in US
children and adults.
AU - Zhu J
AD - Department of Mathematics and Computer Science, Fort Valley State University,
Fort Valley, GA, 31030, USA.
AU - Gao Y
AD - Center for Endemic Disease Control, Chinese Center for Disease Control and
Prevention, Harbin Medical University, Harbin, 150081, China.
AU - Sun D
AD - Center for Endemic Disease Control, Chinese Center for Disease Control and
Prevention, Harbin Medical University, Harbin, 150081, China.
AU - Wei Y
AD - Department of Community Medicine, Mercer University School of Medicine, 1550
College St, Macon, GA, 31207, USA. wei_yd@mercer.edu.
SO - Environ Sci Pollut Res Int. 2018, Apr 12. [Environmental science and
pollution research international]
AB - Nutritional status could affect arsenic metabolism and toxicity in the
general population chronically exposed to low levels of inorganic arsenic.
In this study, we examined the association of serum folate and cobalamin
with urinary concentrations of dimethylarsinic acid (DMA), the most
abundant metabolite of inorganic arsenic measured in urine, in children
and adults who participated in the 2003-2006 US National Health and
Nutrition Examination Surveys. A total of 1161 children (aged
6-19 years) and 1938 adults (aged 20-85 years) were analyzed for
the association using multivariate general linear models, adjusting for
potential confounders. We observed a positive association between serum
levels of folate and cobalamin and creatinine-corrected urinary
concentrations of DMA in both children and adults. Furthermore, serum
levels of folate and cobalamin were inversely associated with homocysteine
(Hcy). These results suggest that dietary intake of folate and cobalamin
may exhibit protective functions against arsenic toxicity by increasing
arsenic metabolism to the less toxic metabolite DMA and decreasing serum
levels of Hcy.
KW - Arsenic metabolism
KW - Cobalamin
KW - Folate
KW - Homocysteine
KW - Urinary dimethylarsinic acid
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180413
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180412
STAT- Publisher
DOCNO- medline/29651724

64 - TOXLINE
TI - Realistic risk assessment of arsenic in rice.
AU - Althobiti RA
AD - Queen's University, Department of Chemistry, 90 Bader Lane, Kingston, ON K7L
3N6, Canada.
AU - Sadiq NW
AD - Queen's University, Department of Chemistry, 90 Bader Lane, Kingston, ON K7L
3N6, Canada.
AU - Beauchemin D
AD - Queen's University, Department of Chemistry, 90 Bader Lane, Kingston, ON K7L
3N6, Canada. Electronic address: diane.beauchemin@chem.queensu.ca.
SO - Food Chem. 2018, Aug 15; 257:230-236. [Food chemistry]
AB - Over 3 billion people share a diet consisting mainly of rice, which may
contain significant amounts of arsenic. Because the toxicity of arsenic is
dependent on its chemical form and that it may be in a form that is not
bio-accessible (i.e. dissolved in the gastrointestinal tract) and can thus
not become bio-available (i.e. end up in the blood stream, where it may
exert its toxic effect), the bio-accessibility of arsenic was determined
in thirteen different types of rice. The effects of washing and cooking
were also studied. The total concentration of arsenic ranged from 93 to
989&#8239;&micro;g&#8239;kg-1 and its bio-accessibility ranged from 16 to
93%. Cooking only changed arsenic speciation in a few cases. However,
simply washing rice with arsenic-free water before cooking removed 3-43%
of the arsenic, resulting in all the rice tested except the most
contaminated one being safe to consume by adults.
KW - Arsenic
KW - Bio-accessibility
KW - Inductively coupled plasma mass spectrometry
KW - Rice
KW - Speciation analysis
LA - eng
IS - 0308-8146 (Print)
PT - Journal Article
TA - Food Chem
YR - 2018
DATE- 20180406
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food chemistry
EDAT- 20180307
STAT- In-Process
DOCNO- medline/29622204

65 - TOXLINE
TI - Role of microRNAs in senescence and its contribution to peripheral
neuropathy in the arsenic exposed population of West Bengal, India.
AU - Chatterjee D
AD - Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology,
Kolkata 700032, India.
AU - Bandyopadhyay A
AD - Health Point Multispeciality Hospital, Kolkata 700025, India; Ramakrishna
Sarada Mission Matri Bhavan, Kolkata 700 026, India.
AU - Sarma N
AD - Dr. B.C. Roy Post Graduate Institute of Paediatric Science, Kolkata 700054,
India.
AU - Basu S
AD - Department of General Medicine, Sri Aurobindo Seva Kendra, Kolkata 700068,
India.
AU - Roychowdhury T
AD - School of Environmental Studies, Jadavpur University, Kolkata 700032, India.
AU - Roy SS
AD - Cell Biology &amp; Physiology Division, CSIR-Indian Institute of Chemical
Biology, Kolkata 700032, India.
AU - Giri AK
AD - Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology,
Kolkata 700032, India. Electronic address: akgiri15@yahoo.com.
SO - Environ Pollut. 2018, Feb; 233:596-603. [Environmental pollution (Barking,
Essex : 1987)]
AB - Arsenic induced senescence (AIS) has been identified in the population of
West Bengal, India very recently. Also there is a high incidence of
arsenic induced peripheral neuropathy (PN) throughout India. However, the
epigenetic regulation of AIS and its contribution in arsenic induced PN
remains unexplored. We recruited seventy two arsenic exposed and forty
unexposed individuals from West Bengal to evaluate the role of senescence
associated miRNAs (SA-miRs) in AIS and their involvement if any, in PN.
The downstream molecules of the miRNA associated with the disease outcome,
was also checked by immuoblotting. In vitro studies were conducted
with HEK 293 cells and sodium arsenite exposure. Our results show
that all the SA-miRs were upregulated in comparison to unexposed controls.
miR-29a was the most significantly altered, highest expression being in
the arsenic exposed group with PN, suggesting its association with the
occurrence of PN. We looked for the expression of peripheral myelin
protein 22 (PMP22), a specific target of miR-29a associated with
myelination and found that both in vitro and in vivo results
showed over-expression of the protein. Since this was quite contrary to
miRNA regulation, we checked for intermediate players &beta;-catenin and
GSK-3&beta; upon arsenic exposure which affects PMP22 expression. We found
that &beta;-catenin was upregulated in vitro and was also highest in
the arsenic exposed group with PN while GSK-3&beta; followed the reverse
pattern. Our findings suggest that arsenic exposure alters the expression
of SA-miRs and the mir-29a/beta catenin/PMP22 axis might be responsible
for arsenic induced PN.
KW - Arsenic
KW - Health effects
KW - Neuropathy
KW - Senescence
KW - miRNA
RN - EC 2.7.11.26
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180406
CI - Copyright &copy; 2017. Published by Elsevier Ltd.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171105
STAT- MEDLINE
DOCNO- medline/29107899

66 - TOXLINE
TI - Antioxidant enzymes responses in shoots of arsenic hyperaccumulator,
Isatis cappadocica Desv., under interaction of arsenate and phosphate.
AU - Souri Z
AD - a Department of Biology, Laboratory of Plant Physiology, Faculty of Science ,
Razi University , Kermanshah , Iran.
AU - Karimi N
AD - a Department of Biology, Laboratory of Plant Physiology, Faculty of Science ,
Razi University , Kermanshah , Iran.
AU - de Oliveira LM
AD - b Soil and Water Science Department , University of Florida , Gainesville ,
FL , USA.
SO - Environ Technol. 2018, May; 39(10):1316-1327. [Environmental technology]
AB - The present study investigated the effects of arsenate and phosphate
interaction on growth, lipid peroxidation, arsenic (As) accumulation,
phosphorus (P) accumulation, and the activities of some antioxidant
enzymes in Isatis cappadocica. Plants were exposed to (50-1200 &mu;mol
L-1) arsenate and (5-1600 &mu;mol L-1) phosphate for 28 days in a
hydroponic system. At a phosphate concentration of 1600&ensp;&micro;M,
biomass production and chlorophyll content increased, demonstrating
clearly that phosphate was able to provide protection against As toxicity.
In case of joint application of 1600 &micro;M phosphate with arsenate, the
As accumulation and then lipid peroxidation were decreased when compared
to samples treated with arsenate and 5 &micro;M phosphate. The activities
of superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT)
and glutathione reductase (GR) increased with increasing arsenate supply
levels. Addition of P decreased activities of SOD, APX and CAT, while high
phosphate treatments had a positive effect on GR activity, which may be
due to regulation of glutathione biosynthesis within the plants. In
conclusion, high arsenate treatment (800-1200 &micro;M) could cause an
increasing oxidative stress, which can be scavenged by the antioxidant
enzyme. Furthermore, P may affect As-induced oxidative stress through
nutrient condition and As accumulation.
KW - Isatis cappadocica
KW - antioxidant enzymes
KW - arsenic
KW - phosphorus
KW - plant tolerance
LA - eng
IS - 0959-3330 (Print)
PT - Journal Article
TA - Environ Technol
YR - 2018
DATE- 20180322
CITO- NLM
CS - England
FJT - Environmental technology
EDAT- 20170527
STAT- In-Process
DOCNO- medline/28488470

67 - TOXLINE
TI - Environmental arsenic exposure: From genetic susceptibility to
pathogenesis.
AU - Minatel BC
AD - Department of Integrative Oncology, British Columbia Cancer Research Centre,
Vancouver, British Columbia, Canada.
AU - Sage AP
AD - Department of Integrative Oncology, British Columbia Cancer Research Centre,
Vancouver, British Columbia, Canada.
AU - Anderson C
AD - Department of Integrative Oncology, British Columbia Cancer Research Centre,
Vancouver, British Columbia, Canada.
AU - Hubaux R
AD - Department of Integrative Oncology, British Columbia Cancer Research Centre,
Vancouver, British Columbia, Canada.
AU - Marshall EA
AD - Department of Integrative Oncology, British Columbia Cancer Research Centre,
Vancouver, British Columbia, Canada.
AU - Lam WL
AD - Department of Integrative Oncology, British Columbia Cancer Research Centre,
Vancouver, British Columbia, Canada.
AU - Martinez VD
AD - Department of Integrative Oncology, British Columbia Cancer Research Centre,
Vancouver, British Columbia, Canada. Electronic address: vmartinez@bccrc.ca.
SO - Environ Int. 2018, Mar; 112:183-197. [Environment international]
AB - More than 200 million people in 70 countries are exposed to arsenic
through drinking water. Chronic exposure to this metalloid has been
associated with the onset of many diseases, including cancer.
Epidemiological evidence supports its carcinogenic potential, however,
detailed molecular mechanisms remain to be elucidated. Despite the global
magnitude of this problem, not all individuals face the same risk.
Susceptibility to the toxic effects of arsenic is influenced by
alterations in genes involved in arsenic metabolism, as well as biological
factors, such as age, gender and nutrition. Moreover, chronic arsenic
exposure results in several genotoxic and epigenetic alterations tightly
associated with the arsenic biotransformation process, resulting in an
increased cancer risk. In this review, we: 1) review the roles of
inter-individual DNA-level variations influencing the susceptibility to
arsenic-induced carcinogenesis; 2) discuss the contribution of arsenic
biotransformation to cancer initiation; 3) provide insights into emerging
research areas and the challenges in the field; and 4) compile a resource
of publicly available arsenic-related DNA-level variations, transcriptome
and methylation data. Understanding the molecular mechanisms of arsenic
exposure and its subsequent health effects will support efforts to reduce
the worldwide health burden and encourage the development of strategies
for managing arsenic-related diseases in the era of personalized medicine.
KW - Arsenic
KW - Cancer
KW - Drinking water
KW - Environmental carcinogens
KW - Epigenetics
KW - Genetic susceptibility
LA - eng
IS - 1873-6750 (Electronic)
PT - Journal Article
PT - Review
TA - Environ Int
YR - 2018
DATE- 20180413
CI - Copyright &copy; 2017 The Authors. Published by Elsevier Ltd.. All rights
reserved.
CITO- NLM
CS - Netherlands
FJT - Environment international
EDAT- 20171222
STAT- In-Data-Review
DOCNO- medline/29275244

68 - TOXLINE
TI - A new family of periplasmic-binding proteins that sense arsenic oxyanions.
AU - Badilla C
AD - Institute of Structural &amp; Molecular Biology, Division of Biosciences,
University College London, London, WC1E 6BT, UK.
AU - Osborne TH
AD - Institute of Structural &amp; Molecular Biology, Division of Biosciences,
University College London, London, WC1E 6BT, UK.
AU - Cole A
AD - Institute of Structural &amp; Molecular Biology, Department of Biological
Sciences, Birkbeck College, University of London, WC1E 7HX, London, UK.
AU - Watson C
AD - Institute of Structural &amp; Molecular Biology, Division of Biosciences,
University College London, London, WC1E 6BT, UK.
AU - Djordjevic S
AD - Institute of Structural &amp; Molecular Biology, Division of Biosciences,
University College London, London, WC1E 6BT, UK. s.djordjevic@ucl.ac.uk.
AU - Santini JM
AD - Institute of Structural &amp; Molecular Biology, Division of Biosciences,
University College London, London, WC1E 6BT, UK. j.santini@ucl.ac.uk.
SO - Sci Rep. 2018, Apr 19; 8(1):6282. [Scientific reports]
AB - Arsenic contamination of drinking water affects more than 140 million
people worldwide. While toxic to humans, inorganic forms of arsenic
(arsenite and arsenate), can be used as energy sources for microbial
respiration. AioX and its orthologues (ArxX and ArrX) represent the first
members of a new sub-family of periplasmic-binding proteins that serve as
the first component of a signal transduction system, that's role is to
positively regulate expression of arsenic metabolism enzymes. As
determined by X-ray crystallography for AioX, arsenite binding only
requires subtle conformational changes in protein structure, providing
insights into protein-ligand interactions. The binding pocket of all
orthologues is conserved but this alone is not sufficient for oxyanion
selectivity, with proteins selectively binding either arsenite or
arsenate. Phylogenetic evidence, clearly demonstrates that the regulatory
proteins evolved together early in prokaryotic evolution and had a
separate origin from the metabolic enzymes whose expression they regulate.
LA - eng
IS - 2045-2322 (Electronic)
PT - Journal Article
TA - Sci Rep
YR - 2018
DATE- 20180501
CITO- NLM
CS - England
FJT - Scientific reports
EDAT- 20180419
STAT- In-Data-Review
CM - Cites: Biochemistry. 2005 Nov 15;44(45):14835-44 (medline /16274231)
CM - Cites: BMC Evol Biol. 2015 Jun 12;15:110 (medline /26067063)
CM - Cites: J Biol Chem. 1992 Nov 25;267(33):23674-82 (medline /1331097)
CM - Cites: J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674 (medline /19461840)
CM - Cites: J Mol Biol. 1993 Jan 5;229(1):105-24 (medline /7678431)
CM - Cites: J Mol Biol. 1997 Jun 27;269(5):719-31 (medline /9223636)
CM - Cites: Environ Sci Technol. 2017 Nov 21;51(22):13353-13362 (medline
/29064247)
CM - Cites: Protein Sci. 1995 Nov;4(11):2411-23 (medline /8563639)
CM - Cites: J Bacteriol. 2010 Jul;192(14):3755-62 (medline /20453090)
CM - Cites: Environ Microbiol. 2012 Jul;14(7):1624-34 (medline /22176720)
CM - Cites: BMC Evol Biol. 2008 Jul 16;8:206 (medline /18631373)
CM - Cites: Mol Biol Evol. 2003 May;20(5):686-93 (medline /12679550)
CM - Cites: Mol Biol Evol. 2013 Dec;30(12):2725-9 (medline /24132122)
CM - Cites: Environ Microbiol. 2012 Jul;14(7):1635-45 (medline /22404962)
CM - Cites: J Bacteriol. 2006 Feb;188(3):1081-8 (medline /16428412)
CM - Cites: Microbiologyopen. 2017 Dec 17;:null (medline /29250936)
CM - Cites: FEBS Lett. 2002 Apr 24;517(1-3):185-9 (medline /12062434)
CM - Cites: FEMS Microbiol Lett. 2017 Aug 15;364(15):null (medline /28859313)
CM - Cites: Cell. 2006 Sep 22;126(6):1095-108 (medline /16990134)
CM - Cites: Biochemistry. 1967 Jul;6(7):1948-54 (medline /6049437)
CM - Cites: J Bacteriol. 1987 May;169(5):2096-102 (medline /2883171)
CM - Cites: Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):235-42
(medline /21460441)
CM - Cites: J Bacteriol. 2004 Mar;186(6):1614-9 (medline /14996791)
CM - Cites: Nucleic Acids Res. 2004 Mar 19;32(5):1792-7 (medline /15034147)
CM - Cites: Environ Microbiol Rep. 2012 Dec;4(6):571-86 (medline /23760928)
CM - Cites: Structure. 2001 Feb 7;9(2):125-32 (medline /11250197)
CM - Cites: BMC Microbiol. 2010 Feb 18;10:53 (medline /20167112)
CM - Cites: J Bacteriol. 2008 Jan;190(1):135-42 (medline /17951391)
CM - Cites: FEMS Microbiol Lett. 2003 Sep 12;226(1):107-12 (medline /13129615)
CM - Cites: J Mol Biol. 1999 Feb 12;286(1):279-90 (medline /9931266)
CM - Cites: Genome Biol Evol. 2013;5(5):934-53 (medline /23589360)
CM - Cites: J Mol Biol. 1990 Oct 5;215(3):403-10 (medline /2231712)
CM - Cites: Genome Biol Evol. 2012;4(3):307-15 (medline /22333491)
CM - Cites: Eur J Biochem. 1998 Aug 1;255(3):647-53 (medline /9738904)
CM - Cites: Appl Environ Microbiol. 2000 Jan;66(1):92-7 (medline /10618208)
CM - Cites: PLoS One. 2013 Aug 30;8(8):e72535 (medline /24023621)
CM - Cites: FEBS Lett. 2016 Dec;590(23 ):4393-4401 (medline /27714801)
CM - Cites: Metallomics. 2013 Apr;5(4):318-24 (medline /23150098)
CM - Cites: Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67
(medline /21460454)
CM - Cites: Appl Environ Microbiol. 2002 Oct;68(10):4795-802 (medline
/12324322)
CM -Cites: FEMS Microbiol Ecol. 2016 Dec;92 (12 ): (medline /27612494)
CM -Cites: J Mol Biol. 2011 Dec 2;414(3):356-69 (medline /22019591)
CM -Cites: J Bacteriol. 1996 Feb;178(4):1219-23 (medline /8576063)
CM -Cites: Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt
1):2126-32 (medline /15572765)
CM - Cites: FEMS Microbiol Lett. 2010 Dec;313(1):20-8 (medline /21039781)
CM - Cites: J Biol Chem. 2006 Dec 15;281(50):38189-99 (medline /17040909)
CM - Cites: Nature. 2002 Jan 31;415(6871):545-9 (medline /11823863)
CM - Cites: Biochim Biophys Acta. 2007 Feb;1767(2):189-96 (medline /17306216)
DOCNO- medline/29674678

69 - TOXLINE
TI - MicroRNA-191, regulated by HIF-2&alpha;, is involved in EMT and
acquisition of a stem cell-like phenotype in arsenite-transformed human
liver epithelial cells.
AU - Chen C
AD - Institute of Toxicology, School of Public Health, Nanjing Medical University,
Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern
Toxicology, Ministry of Education, School of Public Health, Nanjing Medical
University, Nanjing 211166, Jiangsu, People's Republic of China.
AU - Yang Q
AD - Institute of Toxicology, School of Public Health, Nanjing Medical University,
Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern
Toxicology, Ministry of Education, School of Public Health, Nanjing Medical
University, Nanjing 211166, Jiangsu, People's Republic of China.
AU - Wang D
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang
550025, Guizhou, People's Republic of China.
AU - Luo F
AD - Institute of Toxicology, School of Public Health, Nanjing Medical University,
Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern
Toxicology, Ministry of Education, School of Public Health, Nanjing Medical
University, Nanjing 211166, Jiangsu, People's Republic of China.
AU - Liu X
AD - Institute of Toxicology, School of Public Health, Nanjing Medical University,
Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern
Toxicology, Ministry of Education, School of Public Health, Nanjing Medical
University, Nanjing 211166, Jiangsu, People's Republic of China.
AU - Xue J
AD - Institute of Toxicology, School of Public Health, Nanjing Medical University,
Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern
Toxicology, Ministry of Education, School of Public Health, Nanjing Medical
University, Nanjing 211166, Jiangsu, People's Republic of China.
AU - Yang P
AD - The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou
Medical University, Guangzhou 510182, Guangdong, People's Republic of China.
AU - Xu H
AD - Institute of Toxicology, School of Public Health, Nanjing Medical University,
Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern
Toxicology, Ministry of Education, School of Public Health, Nanjing Medical
University, Nanjing 211166, Jiangsu, People's Republic of China.
AU - Lu J
AD - The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou
Medical University, Guangzhou 510182, Guangdong, People's Republic of China.
AU - Zhang A
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University, Guiyang
550025, Guizhou, People's Republic of China. Electronic address:
aihuagzykd@163.com.
AU - Liu Q
AD - Institute of Toxicology, School of Public Health, Nanjing Medical University,
Nanjing 211166, Jiangsu, People's Republic of China; The Key Laboratory of Modern
Toxicology, Ministry of Education, School of Public Health, Nanjing Medical
University, Nanjing 211166, Jiangsu, People's Republic of China. Electronic
address: qzliu@njmu.edu.cn.
SO - Toxicol In Vitro. 2018, Apr; 48:128-136. [Toxicology in vitro : an
international journal published in association with BIBRA]
AB - Inorganic arsenic is widely distributed in the environment, and
epidemiologic data show a strong association between arsenic exposure and
risk of liver cancer. An understanding of the mechanisms underlying
development of liver cancer and metastasis would be useful in reducing the
incidence and mortality of liver cancer. MicroRNAs (miRs) act as
regulators in liver cancer. Here, we show that acute or chronic exposure
of human liver epithelial L-02 cells to arsenite increased expression of
miR-191. There were decreased levels of BASP-1 and E-cadherin and
increased levels of WT-1 and N-cadherin, indicating that arsenite induced
epithelial-mesenchymal transition (EMT). Moreover, arsenite increased
EpCAM and CD90 mRNA levels, showing the acquisition of stem cell-like
properties by these cells. Suppression of miR-191 resulted in repression
of EMT and reduced expression of stem-cell markers. Further, a miR-191
inhibitor blocked spheroid formation and production of side population
cells. Luciferase reporter assays indicated that miR-191 was a target of
HIF-2&alpha;, and inhibition of miR-191 decreased the neoplastic and
metastatic properties of arsenite-transformed L-02 cells. Thus, in
arsenite-transformed liver epithelial cells, transcriptional activation of
the miR-191 promoter by HIF-2&alpha; is involved in EMT and in the
acquisition of a stem cell-like phenotype.
KW - Arsenic poisoning
KW - Cancer stem cells (CSCs)
KW - Epithelial-mesenchymal transition (EMT)
KW - Experimental carcinogenesis
KW - miR-191
LA - eng
IS - 1879-3177 (Electronic)
PT - Journal Article
TA - Toxicol In Vitro
YR - 2018
DATE- 20180305
CI - Copyright &copy; 2017. Published by Elsevier Ltd.
CITO- NLM
CS - England
FJT - Toxicology in vitro : an international journal published in association
with BIBRA
EDAT- 20171224
STAT- In-Process
DOCNO- medline/29277653

70 - TOXLINE
TI - High catalytic oxidation of As(III) by molecular oxygen over Fe-loaded
silicon carbide with MW activation.
AU - Pan H
AD - School of Environmental Science and Engineering, Huazhong University of
Science and Technology, 1037 Luoyu Road, Wuhan, 430074, PR China.
AU - Hou H
AD - School of Environmental Science and Engineering, Huazhong University of
Science and Technology, 1037 Luoyu Road, Wuhan, 430074, PR China.
AU - Shi Y
AD - School of Environmental Science and Engineering, Huazhong University of
Science and Technology, 1037 Luoyu Road, Wuhan, 430074, PR China.
AU - Li H
AD - School of Environmental Science and Engineering, Huazhong University of
Science and Technology, 1037 Luoyu Road, Wuhan, 430074, PR China.
AU - Chen J
AD - School of Environmental Science and Engineering, Huazhong University of
Science and Technology, 1037 Luoyu Road, Wuhan, 430074, PR China. Electronic
address: chenjing@mail.hust.edu.cn.
AU - Wang L
AD - School of Environmental Science and Engineering, Huazhong University of
Science and Technology, 1037 Luoyu Road, Wuhan, 430074, PR China. Electronic
address: wanglinling@mail.hust.edu.cn.
AU - Crittenden JC
AD - Brook Byers Institute for Sustainable Systems, School of Civil and
Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
SO - Chemosphere. 2018, May; 198:537-545. [Chemosphere]
AB - The catalytic oxidation of arsenite (As(III)) to arsenate (As(V)) and the
removal of arsenic (As) in an iron loaded silicon carbide (Fe/SiC) system
under microwave (MW) irradiation were studied. Fe/SiC was synthesized by
electro-deposition and its capability of activating molecular oxygen was
also characterized. Highly efficient As(III) removal in a wide pH range of
2.5-9.5 was achieved, involving oxidation by reactive oxidation species
(OH and O2-) induced by MW irradiation and adsorption by the generated Fe
(hrdro)oxide precipitates. Significant enhancement of As(III) oxidation
was achieved at acidic pH, where sequential fresh Fe(0) exposure with MW
irradiation could improve the Fenton-like reactions and oxidation
efficiency for As(III). As(III) removal was accelerated via adsorption at
alkaline conditions, where the adsorbed Fe(II) on Fe/SiC showed
significant catalytic activity for molecular oxygen and high pH further
favored the formation of (hydro)oxides and the As sequestration by
adsorption. Fe/SiC showed superior performance for the treatment of As in
water with MW irradiation.
KW - Arsenite
KW - Fe arsenic complex
KW - Fe/SiC
KW - MW irradiation
KW - Molecular oxygen activation
RN - E1UOL152H7
RN - N5509X556J
RN - N712M78A8G
RN - N7CIZ75ZPN
RN - S88TT14065
RN - WXQ6E537EW
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180612
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180208
STAT- MEDLINE
DOCNO- medline/29428768
71 - TOXLINE
TI - Combinatorial drug delivery strategy employing nano-curcumin and
nano-MiADMSA for the treatment of arsenic intoxication in mouse.
AU - Kushwaha P
AD - Division of Regulatory Toxicology, Defence Research and Development
Establishment, Jhansi Road, Gwalior 474002, M.P., India.
AU - Yadav A
AD - Division of Regulatory Toxicology, Defence Research and Development
Establishment, Jhansi Road, Gwalior 474002, M.P., India.
AU - Samim M
AD - Jamia Hamdard, New Delhi, India.
AU - Flora SJS
AD - National Institute of Pharmaceutical Education and Research, Raebareli
209010, U.P., India. Electronic address: sjsflora@hotmail.com.
SO - Chem Biol Interact. 2018, Apr 25; 286:78-87. [Chemico-biological
interactions]
AB - Chelation therapy is the mainstream treatment for heavy metal poisoning.
Apart from this, therapy using antioxidant/herbal extracts are the other
strategies now commonly being tried for the treatment. We have previously
reported individual beneficial efficacy of nanoparticle mediated
administration of an antioxidant like 'curcumin' and an arsenic chelator
'monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA)' for the treatment of
arsenic toxicity compared to bulk drugs. The present paper investigates
our hypothesis that a combination drug delivery therapy employing two
nanosystems, a chelator and a strong antioxidant, may produce more
pronounced therapeutic effects compared to individual effects in the
treatment of arsenic toxicity. An in-vivo study was conducted wherein
arsenic as sodium arsenite (100&#8239;ppm) was administered in drinking
water for 5 months to Swiss albino mice. This was followed by a treatment
protocol comprising of curcumin encapsulated chitosan nanoparticles
(nano-curcumin, 15&#8239;mg/kg, orally for 1 month) either alone or in
combination with MiADMSA encapsulated polymeric nanoparticles
(nano-MiADMSA, 50&#8239;mg/kg for last 5 days) to evaluate the therapeutic
potential of the combination treatment. Our results demonstrated that
co-treatment with nano-curcumin and nano-MiADMSA provided beneficial
effects in a synergistic way on the adverse changes in oxidative stress
parameters and metal status induced by arsenic.
KW - Arsenic
KW - Curcumin
KW - DMSA monoester
KW - Metal toxicity
KW - Nanoencapsulation
KW - Nanotherapy
KW - Oxidative stress
RN - 88847-89-6
RN - DX1U2629QE
RN - G9481N71RO
RN - GAN16C9B8O
RN - IT942ZTH98
RN - N712M78A8G
LA - eng
IS - 1872-7786 (Electronic)
PT - Journal Article
TA - Chem Biol Interact
YR - 2018
DATE- 20180418
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Ireland
CSET- IM
FJT - Chemico-biological interactions
EDAT- 20180313
STAT- MEDLINE
DOCNO- medline/29548727

72 - TOXLINE
TI - Possible bioremediation of arsenic toxicity by isolating indigenous
bacteria from the middle Gangetic plain of Bihar, India.
AU - Satyapal GK
AD - Centre for Biological Sciences (Biotechnology), Central University of South
Bihar, Patna, Bihar, India.
AU - Mishra SK
AD - Centre for Biological Sciences (Biotechnology), Central University of South
Bihar, Patna, Bihar, India.
AU - Srivastava A
AD - Centre for Biological Sciences (Life Science), Central University of South
Bihar, Patna, Bihar, India.
AU - Ranjan RK
AD - Centre for Environmental Sciences, Central University of South Bihar, Patna,
Bihar, India.
AU - Prakash K
AD - Centre for Biological Sciences (Biotechnology), Central University of South
Bihar, Patna, Bihar, India.
AU - Haque R
AD - Centre for Biological Sciences (Biotechnology), Central University of South
Bihar, Patna, Bihar, India.
AU - Kumar N
AD - Centre for Biological Sciences (Biotechnology), Central University of South
Bihar, Patna, Bihar, India.
SO - Biotechnol Rep (Amst). 2018, Mar; 17:117-125. [Biotechnology reports
(Amsterdam, Netherlands)]
AB - In middle Gangetic plain, high arsenic concentration is present in water,
which causes a significant health risk. Total 48 morphologically distinct
arsenite resistant bacteria were isolated from middle Gangetic plain. The
minimum inhibitory concentration (MIC) values of arsenite varied widely in
the range 1-15&#8239;mM of the isolates. On the basis of their MIC, two
isolates, AK1 (KY569423) and AK9 (KY569424) were selected. The analysis of
the 16S rRNA gene sequence of selected isolates revealed that they are
belong to the genus Pseudomonas. The AgNO3 test based microplate method
revealed that isolates, AK1 and AK9, have potential in transformation of
arsenic species. Further, the presence of aoxR, aoxB and aoxC genes in the
both isolated strain AK1 and AK9 was confirmed, which play an important
role in arsenic bioremediation by arsenite oxidation. Isolated strains
also showed heavy metal resistance against Cr(IV), Ni(II), Co(II), Pb(II),
Cu(II), Hg(II), Ag(I) and Cd(II).
KW - Arsenic
KW - Bacteria
KW - Bioremediation
KW - Middle Gangetic plain
KW - Oxidation
LA - eng
IS - 2215-017X (Print)
PT - Journal Article
TA - Biotechnol Rep (Amst)
YR - 2018
DATE- 20180318
CITO- NLM
CS - Netherlands
FJT - Biotechnology reports (Amsterdam, Netherlands)
EDAT- 20180208
STAT- PubMed-not-MEDLINE
CM - Cites: FEMS Microbiol Lett. 2004 Aug 15;237(2):249-53 (medline /15321669)
CM - Cites: Environ Geochem Health. 2010 Apr;32(2):95-105 (medline /19548094)
CM - Cites: Appl Microbiol Biotechnol. 2013 May;97(9):3827-41 (medline
/23546422)
CM - Cites: FEBS Lett. 2002 Oct 2;529(1):86-92 (medline /12354618)
CM - Cites: Appl Environ Microbiol. 2005 Feb;71(2):599-608 (medline /15691908)
CM - Cites: J Biotechnol. 2010 Oct 1;150(1):101-7 (medline /20638426)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2014;49(12):1349-60 (medline /25072766)
CM - Cites: Environ Health Perspect. 2003 Jul;111(9):1194-201 (medline
/12842773)
CM - Cites: J Contam Hydrol. 2011 Apr 1;123(1-2):20-9 (medline /21216490)
CM - Cites: Int Microbiol. 2006 Sep;9(3):207-15 (medline /17061211)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2011;46(14):1736-47 (medline /22175878)
DOCNO- medline/29541605

73 - TOXLINE
TI - Arsenic exposure to breast-fed infants: contaminated breastfeeding in the
first month of birth.
AU - Salmani MH
AD - Department of Environmental Health Engineering, School of Public Health,
Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
AU - Rezaie Z
AD - Research Center for Food Hygiene and Safety, School of Public Health, Shahid
Sadoughi University of Medical Sciences, Yazd, Iran. rezaeizeynab91@gmail.com.
AU - Mozaffari-Khosravi H
AD - Department of Nutrition, School of Public Health, Shahid Sadoughi University
of Medical Sciences, Yazd, Iran.
AU - Ehrampoush MH
AD - Environmental Science and Research Center,School of Public Health, Shahid
Sadoughi University of Medical Sciences, Yazd, Iran.
SO - Environ Sci Pollut Res Int. 2018, Mar; 25(7):6680-6684. [Environmental
science and pollution research international]
AB - Humans are exposed to heavy metals through ingestion, inhalation, and
dermal absorption. Exposure to these chemicals may be possible during
lactation. Although breastfeeding has import benefits of physical growth
and development of breastfed infants, it may be a source of exposure to
toxicants. The present study was conducted to determine infant exposure to
the arsenic via breastfeeding. The milk samples were collected from the
150 volunteering mothers three times during the first month of lactation
after delivery. The average arsenic concentration in breast milk samples
was measured by atomic absorption spectrometer (AAS). The demographic
parameters of lactating mothers were collected by a questionnaire and were
analyzed using SPSS 18 software. Arsenic was not detectable in 71 of 150
samples (47.3%). The highest arsenic concentration was 3.73 &mu;g/L,
and overall mean of arsenic concentration was
0.87&thinsp;&plusmn;&thinsp;0.66 &mu;g/L. The daily infant intake of
arsenic ranged in the 0.01-0.17 &mu;g/kg of body weight, which is
below the limit of daily permissible intake for adults. Our results showed
the need to strengthen national food safety programs and to further
promote avoidance of unhealthy foods consuming during pregnancy. Most of
the study samples had detectable levels of arsenic indicate that there was
maternal exposure prior to pregnancy, nevertheless, it is recommended that
the toxic metal levels should be regularly monitored in biological
environments.
KW - Arsenic
KW - Breastfeeding
KW - Infant exposure
KW - Lactation
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180305
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171219
STAT- In-Process
CM - Cites: J Prev Med Public Health. 2014 Sep;47(5):245-52 (medline /25284195)
CM - Cites: Biol Trace Elem Res. 2012 Oct;149(1):117-22 (medline /22528772)
CM - Cites: Environ Health Perspect. 2008 Jul;116(7):963-9 (medline /18629322)
CM - Cites: Trends Plant Sci. 2004 Sep;9(9):415-7 (medline /15337490)
CM - Cites: Environ Int. 2009 Apr;35(3):473-5 (medline /18775567)
CM - Cites: J Hazard Mater. 2007 Apr 2;142(1-2):1-53 (medline /17324507)
CM - Cites: Int J Hyg Environ Health. 2002 Jul;205(5):405-9 (medline /12173541)
CM - Cites: Matern Child Health J. 2010 Jan;14(1):141-5 (medline /19093194)
CM - Cites: Food Chem Toxicol. 1999 Aug;37(8):839-46 (medline /10506007)
CM - Cites: BMC Med. 2004 Jul 01;2:26 (medline /15230974)
CM - Cites: Environ Health Perspect. 2015 May;123(5):500-6 (medline /25707031)
DOCNO- medline/29260474

74 - TOXLINE
TI - Detection of arsenic-binding siderophores in arsenic-tolerating
Actinobacteria by a modified CAS assay.
AU - Retamal-Morales G
AD - Universidad de Santiago de Chile, Laboratorio de Microbiolog�a B�sica y
Aplicada, Facultad de Qu�mica y Biolog�a, Santiago, Chile; TU Bergakademie
Freiberg, Interdisciplinary Ecological Center, 09599 Freiberg, Germany. Electronic
address: gerardo.retamal@usach.cl.
AU - Mehnert M
AD - TU Bergakademie Freiberg, Interdisciplinary Ecological Center, 09599
Freiberg, Germany.
AU - Schwabe R
AD - TU Bergakademie Freiberg, Interdisciplinary Ecological Center, 09599
Freiberg, Germany.
AU - Tischler D
AD - TU Bergakademie Freiberg, Interdisciplinary Ecological Center, 09599
Freiberg, Germany. Electronic address: dirk.tischler@ioez.tu-freiberg.de.
AU - Zapata C
AD - Universidad de Santiago de Chile, Laboratorio de Microbiolog�a B�sica y
Aplicada, Facultad de Qu�mica y Biolog�a, Santiago, Chile.
AU - Ch�vez R
AD - Universidad de Santiago de Chile, Laboratorio de Microbiolog�a B�sica y
Aplicada, Facultad de Qu�mica y Biolog�a, Santiago, Chile.
AU - Schl�mann M
AD - TU Bergakademie Freiberg, Interdisciplinary Ecological Center, 09599
Freiberg, Germany. Electronic address: michael.schloemann@ioez.tu-freiberg.de.
AU - Levic�n G
AD - Universidad de Santiago de Chile, Laboratorio de Microbiolog�a B�sica y
Aplicada, Facultad de Qu�mica y Biolog�a, Santiago, Chile. Electronic address:
gloria.levican@usach.cl.
SO - Ecotoxicol Environ Saf. 2018, Aug 15; 157:176-181. [Ecotoxicology and
environmental safety]
AB - The metalloid arsenic is highly toxic to all forms of life, and in many
countries decontamination of water and soil is still required. Some
bacteria have mechanisms to detoxify arsenic and can live in its presence.
Actinobacteria are well known for their ability to produce a myriad of
biologically-active compounds. In the present study, we isolated
arsenic-tolerant Actinobacteria from contaminated water in Saxony,
Germany, and determined their ability to produce siderophores able to bind
arsenic. The binding capacity of different siderophore-like compounds was
determined by a modified chrome azurol S (As-mCAS) assay with As(III) at
high pH and using CAS decolorization as a readout. Arsenic-tolerant
isolates from three actinobacterial genera were identified by 16&#8239;S
rRNA gene sequence analysis: Rhodococcus, Arthrobacter and Kocuria. The
isolated Actinobacteria showed a high As(III)-binding activity by
siderophore-like compounds, resulting in 82-100% CAS decolorization, as
compared to the results with EDTA. The interaction between As(III) and
siderophore-like compounds was also detected at neutral pH. In summary,
our results suggest that the isolated arsenic-tolerant Actinobacteria
produce siderophores that bind arsenic, and open new perspectives on
potential candidates for decontaminating environments with arsenic and for
other biotechnological applications.
KW - Actinobacteria
KW - Arsenic
KW - As-(m)CAS assay
KW - Bioremediation
KW - CAS assay
KW - Siderophore
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180424
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180402
STAT- In-Process
DOCNO- medline/29621709

75 - TOXLINE
TI - Speciation analysis of inorganic arsenic by magnetic solid phase
extraction on-line with inductively coupled mass spectrometry
determination.
AU - Montoro Leal P
AD - Department of Analytical Chemistry, Faculty of Sciences, University of
Malaga, Campus of Teatinos, 29071 M�laga, Spain.
AU - Vereda Alonso E
AD - Department of Analytical Chemistry, Faculty of Sciences, University of
Malaga, Campus of Teatinos, 29071 M�laga, Spain. Electronic address:
eivereda@uma.es.
AU - L�pez Guerrero MM
AD - Department of Analytical Chemistry, Faculty of Sciences, University of
Malaga, Campus of Teatinos, 29071 M�laga, Spain. Electronic address:
mmlopez@uma.es.
AU - Cordero MTS
AD - Department of Analytical Chemistry, Faculty of Sciences, University of
Malaga, Campus of Teatinos, 29071 M�laga, Spain.
AU - Cano Pav�n JM
AD - Department of Analytical Chemistry, Faculty of Sciences, University of
Malaga, Campus of Teatinos, 29071 M�laga, Spain.
AU - Garc�a de Torres A
AD - Department of Analytical Chemistry, Faculty of Sciences, University of
Malaga, Campus of Teatinos, 29071 M�laga, Spain.
SO - Talanta. 2018, Jul 01; 184:251-259. [Talanta]
AB - Arsenic, one of the main environmental pollutants and potent natural
poison, is a chemical element that is spread throughout the Earth's crust.
It is well known that the toxicity of arsenic is highly dependent on its
chemical forms. Generally, the inorganic species are more toxic than its
organics forms, and As(III) is 60 times more toxic than As(V). In
environmental waters, arsenic exists predominantly in two chemical forms:
As(III) and As(V). In view of these facts, fast, sensitive, accurate and
simple analytical methods for the speciation of inorganic arsenic in
environmental waters are required. In this work, a new magnetic solid
phase extraction with a hydride generation system was coupled on line with
inductively coupled plasma mass spectrometry (MSPE-HG-ICP-MS). The new
system was based on the retention of As(III) and As(V) in two knotted
reactors filled with (Fe3O4) magnetic nanoparticles functionalized with
[1,5-bis (2-pyridyl) 3-sulfophenylmethylene] thiocarbonohydrazide
(PSTH-MNPs). As(III) and total inorganic As were sequentially eluted in
different reduction conditions. The concentration of As(V) was obtained by
subtracting As(III) from total As. The system runs in a fully automated
way and the method has proved to have a wide linear range and to be
precise, sensitive and fast. The detection limits found were 2.7 and
3.2&#8239;ng/L for As(III) and total As, respectively; with relative
standard deviations (RSDs) of 2.5% and 2.7% and a sample throughput of
14.4&#8239;h-1. In order to validate the developed method, several
certified reference samples of environmental waters including sea water,
were analyzed and the determined values were in good agreement with the
certified values. The proposed method was successfully applied to the
speciation analysis of inorganic arsenic in well-water and sea water.
KW - Arsenic speciation
KW - Hydride generation
KW - ICP-MS
KW - Magnetic nanoparticles
KW - Solid phase extraction
LA - eng
IS - 1873-3573 (Electronic)
PT - Journal Article
TA - Talanta
YR - 2018
DATE- 20180427
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Talanta
EDAT- 20180308
STAT- PubMed-not-MEDLINE
DOCNO- medline/29674040

76 - TOXLINE
TI - Distribution of Arsenic and Risk Assessment of Activities on Soccer
Pitches Irrigated with Arsenic-Contaminated Water.
AU - Mart�nez-Villegas N
AD - IPICyT, Instituto Potosino de Investigacion Cientifica y Tecnologica,
Division de Geociencias Aplicadas, Camino a la Presa San Jose No. 2055, Col. Lomas
4a Sec., San Luis Potosi 78216, SLP, Mexico. nadia.martinez@ipicyt.edu.mx.
AU - Hern�ndez A
AD - IPICyT, Instituto Potosino de Investigacion Cientifica y Tecnologica,
Division de Geociencias Aplicadas, Camino a la Presa San Jose No. 2055, Col. Lomas
4a Sec., San Luis Potosi 78216, SLP, Mexico. abraham.hernandez@ipicyt.edu.mx.
AU - Meza-Figueroa D
AD - Departamento de Geolog�a, Universidad de Sonora, Rosales y Encinas s/n, Col.
Centro, Hermosillo 83000, Sonora, Mexico. dmeza@ciencias.uson.mx.
AU - Sen Gupta B
AD - School of Energy, Geoscience, Infrastructure &amp; Society, Institute for
Infrastructure and Environment, Water Academy, Heriot-Watt University, EGIS 2.02A
William Arrol Building, Scotland EH14 4AS, UK. B.SenGupta@hw.ac.uk.
SO - Int J Environ Res Public Health. 2018, May 24. [International journal of
environmental research and public health]
AB - The aim of this research was to estimate the risk of human exposure to
arsenic due to sporting activities in a private soccer club in Mexico,
where arsenic-contaminated water was regularly used for irrigation. For
this purpose, the total concentration in the topsoil was considered for
risk assessment. This was accomplished through three main objectives: (1)
measuring arsenic concentrations in irrigation water and irrigated soils,
(2) determining arsenic spatial distribution in shallow soils with
Geographical Information Systems (GIS) using geostatistical analysis, and
(3) collecting field and survey data to develop a risk assessment
calculation for soccer activities in the soccer club. The results showed
that the average arsenic concentrations in shallow soils (138.1 mg/kg)
were 6.2 times higher than the Mexican threshold for domestic soils (22
mg/kg). Furthermore, dermal contact between exposed users and contaminated
soils accounted for a maximum carcinogenic risk value of 1.8 &amp;times;
10&amp;minus;5, which is one order of magnitude higher than the
recommended risk value, while arsenic concentrations in the irrigation
water were higher (6 mg/L) than the WHO&amp;rsquo;s permissible threshold
in drinking water, explaining the contamination of soils after irrigation.
To the best of our knowledge, this is the first risk study regarding
dermal contact with arsenic following regular grass irrigation with
contaminated water in soccer pitches.
KW - arsenic
KW - irrigation
KW - risk characterization
KW - soccer fields
KW - soil
KW - water
LA - eng
IS - 1660-4601 (Electronic)
PT - Journal Article
TA - Int J Environ Res Public Health
YR - 2018
DATE- 20180608
CITO- NLM
CS - Switzerland
FJT - International journal of environmental research and public health
EDAT- 20180524
STAT- In-Data-Review
DOCNO- medline/29882913

77 - TOXLINE
TI - Arsenic removal by perilla leaf biochar in aqueous solutions and
groundwater: An integrated spectroscopic and microscopic examination.
AU - Niazi NK
AD - Institute of Soil and Environmental Sciences, University of Agriculture
Faisalabad, Faisalabad 38040, Pakistan; MARUM and Department of Geosciences,
University of Bremen, Bremen D-28359, Germany; Southern Cross GeoScience, Southern
Cross University, Lismore 2480 NSW, Australia. Electronic address:
nabeelkniazi@gmail.com.
AU - Bibi I
AD - Institute of Soil and Environmental Sciences, University of Agriculture
Faisalabad, Faisalabad 38040, Pakistan; MARUM and Department of Geosciences,
University of Bremen, Bremen D-28359, Germany.
AU - Shahid M
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, Pakistan.
AU - Ok YS
AD - Korea Biochar Research Center, O-Jeong Eco-Resilience Institute (OJERI) &amp;
Division of Environmental Science and Ecological Engineering, Korea University,
Seoul 02841, Republic of Korea.
AU - Burton ED
AD - Southern Cross GeoScience, Southern Cross University, Lismore 2480 NSW,
Australia.
AU - Wang H
AD - Key Laboratory of Soil Contamination Bioremediation of Zhejiang Province,
Zhejiang A &amp; F University, Lin'an, Hangzhou 311300, China; School of
Environment and Chemical Engineering, Foshan University, Foshan 528000, China.
AU - Shaheen SM
AD - University of Kafrelsheikh, Faculty of Agriculture, Department of Soil and
Water Sciences, 33 516 Kafr El-Sheikh, Egypt; University of Wuppertal, School of
Architecture and Civil Engineering, Institute of Foundation Engineering, Water- and
Waste-Management, Soil- and Groundwater-Management, Pauluskirchstra&szlig;e 7,
42285 Wuppertal, Germany.
AU - Rinklebe J
AD - University of Wuppertal, School of Architecture and Civil Engineering,
Institute of Foundation Engineering, Water- and Waste-Management, Soil- and
Groundwater-Management, Pauluskirchstra&szlig;e 7, 42285 Wuppertal, Germany;
Department of Environment and Energy, Sejong University, 98 Gunja-Dong, Guangjin-
Gu, Seoul, South Korea.
AU - L�ttge A
AD - MARUM and Department of Geosciences, University of Bremen, Bremen D-28359,
Germany.
SO - Environ Pollut. 2018, Jan; 232:31-41. [Environmental pollution (Barking,
Essex : 1987)]
AB - In this study, we examined the removal of arsenite (As(III)) and arsenate
(As(V)) by perilla leaf-derived biochars produced at 300 and
700 &deg;C (referred as BC300 and BC700) in aqueous environments.
Results revealed that the Langmuir isotherm model provided the best fit
for As(III) and As(V) sorption, with the sorption affinity following the
order:
BC700-As(III) > BC700-As(V) > BC300-As(III)
> BC300-As(V)
(QL = 3.85-11.01 mg g-1). In general, As removal
decreased (76-60%) with increasing pH from 7 to 10 except for the
BC700-As(III) system, where notably higher As removal (88-90%) occurred at
pH from 7 to 9. Surface functional moieties contributed to As
sequestration by the biochars examined here. However, significantly higher
surface area and aromaticity of BC700 favored a greater As removal
compared to BC300, suggesting that surface complexation/precipitation
dominated As removal by BC700. Arsenic K-edge X-ray absorption near edge
structure (XANES) spectroscopy demonstrated that up to 64% of the added
As(V) was reduced to As(III) in BC700- and BC300-As(V) sorption
experiments, and in As(III) sorption experiments, partial oxidation of
As(III) to As(V) occurred (37-39%). However, XANES spectroscopy was
limited to precisely quantify As binding with sulfur species as As2S3-like
phase. Both biochars efficiently removed As from natural As-contaminated
groundwater (As: 23-190 &mu;g L-1; n = 12) despite in
the presence of co-occurring anions (e.g., CO32-, PO43-, SO42-) with the
highest levels of As removal observed for BC700 (97-100%). Overall, this
study highlights that perilla leaf biochars, notably BC700, possessed the
greatest ability to remove As from solution and groundwater (drinking
water). Significantly, the integrated spectroscopic techniques advanced
our understanding to examine complex redox transformation of As(III)/As(V)
with biochar, which are crucial to determine fate of As on biochar in
aquatic environments.
KW - Arsenic toxicity
KW - Drinking water
KW - Groundwater remediation
KW - Sorbent
KW - Water filtration
KW - XANES
RN - 16291-96-6
RN - N5509X556J
RN - N712M78A8G
RN - N7CIZ75ZPN
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180208
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20170929
STAT- MEDLINE
DOCNO- medline/28966026

78 - TOXLINE
TI - Combination of HPLC with organic and inorganic mass spectrometry to study
the metabolic response of the clam Scrobicularia plana to arsenic
exposure.
AU - Rodr�guez-Moro G
AD - Research Center of Health and Environment (CYSMA). University of Huelva,
Huelva, Spain.
AU - Garc�a-Barrera T
AD - Research Center of Health and Environment (CYSMA). University of Huelva,
Huelva, Spain.
AU - Trombini C
AD - Institute for Marine Sciences of Andaluc�a (ICMAN), Ciudad Real, Spain.
AU - Blasco J
AD - Institute for Marine Sciences of Andaluc�a (ICMAN), Ciudad Real, Spain.
AU - G�mez-Ariza JL
AD - Research Center of Health and Environment (CYSMA). University of Huelva,
Huelva, Spain.
SO - Electrophoresis. 2018, Feb; 39(4):635-644. [Electrophoresis]
AB - Arsenic is a toxic element extensively studied in the marine environment
due to differential toxicological effects of inorganic and organic
species. In the present work, the bivalve Scrobicularia plana was exposed
to AsV (10 and 100 &mu;g/L) for 14 days to evaluate the metabolic
perturbations caused by this element. Arsenic speciation and metabolomic
analysis were performed in the digestive gland of the bivalve using two
complementary analytical platforms based on inorganic and organic mass
spectrometry. It has been observed the greater presence of the innocuous
specie arsenobetaine produced in this organism as defense mechanism
against arsenic toxicity, although significant concentrations of
methylated and inorganic arsenic were also present, depending on the level
of arsenic in aqueous media. Complementarily, a metabolomic study based on
mass spectrometry and statistical discriminant analysis allows a good
classification of samples associated to low and high As(V) exposure in
relation to controls. About 15 metabolites suffer significant changes of
expression by the presence of As(V): amino acids, nucleotides,
energy-related metabolites, free fatty acids, phospholipids and
triacylglycerides, which can be related to membrane structural and
functional damage. In addition, perturbation of the methylation cycle,
associated with the increase of homocysteine and methionine was observed,
which enhance the methylation of toxic inorganic arsenic to less toxic
dimethylarsenic.
KW - Arsenic speciation
KW - DI-ESI-Qq-TOF-MS
KW - HPLC-ICP-MS
KW - Metabolomics
KW - Scrobicularia plana
LA - eng
IS - 1522-2683 (Electronic)
PT - Journal Article
TA - Electrophoresis
YR - 2018
DATE- 20180214
CI - &copy; 2017 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.
CITO- NLM
CS - Germany
FJT - Electrophoresis
EDAT- 20171211
STAT- In-Data-Review
DOCNO- medline/29125650

79 - TOXLINE
TI - PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in
Carcinogenesis.
AU - Chen QY
AD - Department of Environmental Medicine, New York University School of Medicine,
Tuxedo, New York.
AU - Costa M
AD - Department of Environmental Medicine, New York University School of Medicine,
Tuxedo, New York Max.Costa@nyumc.org.
SO - Mol Pharmacol. 2018, Jul; 94(1):784-792. [Molecular pharmacology]
AB - Arsenic is a naturally occurring, ubiquitous metalloid found in the
Earth's crust. In its inorganic form, arsenic is highly toxic and
carcinogenic and is widely found across the globe and throughout the
environment. As an International Agency for Research on Cancer-defined
class 1 human carcinogen, arsenic can cause multiple human cancers,
including liver, lung, urinary bladder, skin, kidney, and prostate.
Mechanisms of arsenic-induced carcinogenesis remain elusive, and this
review focuses specifically on the role of the PI3K/AKT/mTOR pathway in
promoting cancer development. In addition to exerting potent carcinogenic
responses, arsenic is also known for its therapeutic effects against acute
promyelocytic leukemia. Current literature suggests that arsenic can
achieve both therapeutic as well as carcinogenic effects, and this review
serves to examine the paradoxical effects of arsenic, specifically through
the PI3K/AKT/mTOR pathway. Furthermore, a comprehensive review of current
literature reveals an imperative need for future studies to establish and
pinpoint the exact conditions for which arsenic can, and through what
mechanisms it is able to, differentially regulate the PI3K/AKT/mTOR
pathway to maximize the therapeutic and minimize the carcinogenic
properties of arsenic.
LA - eng
IS - 1521-0111 (Electronic)
PT - Journal Article
TA - Mol Pharmacol
YR - 2018
DATE- 20180616
CI - Copyright &copy; 2018 by The Author(s).
CITO- NLM
CS - United States
FJT - Molecular pharmacology
EDAT- 20180516
STAT- In-Data-Review
DOCNO- medline/29769245

80 - TOXLINE
TI - Reduction of arsenic toxicity in two rice cultivar seedlings by different
nanoparticles.
AU - Huang Q
AD - Agro-Environmental Protection Institute, Ministry of Agriculture, Tianjin
300191, China; School of Land and Environmental, Shenyang Agriculture University,
Shenyang 110000, China.
AU - Liu Q
AD - Geophysical Exploration Academy of China Metallurgical Geology Bureau,
Baoding 071051, China.
AU - Lin L
AD - School of Land and Environmental, Shenyang Agriculture University, Shenyang
110000, China.
AU - Li FJ
AD - Agro-Environmental Protection Institute, Ministry of Agriculture, Tianjin
300191, China.
AU - Han Y
AD - Geophysical Exploration Academy of China Metallurgical Geology Bureau,
Baoding 071051, China.
AU - Song ZG
AD - Agro-Environmental Protection Institute, Ministry of Agriculture, Tianjin
300191, China. Electronic address: forestman1218@163.com.
SO - Ecotoxicol Environ Saf. 2018, Sep 15; 159:261-271. [Ecotoxicology and
environmental safety]
AB - In this study, we investigated arsenic uptake and enzymatic activities in
rice seedlings after the addition of nanoparticles. Hydroponic experiments
were conducted to investigate the effects of different nanomaterials
(high-quality graphene oxide, multilayer graphene oxide, 20&#8239;nm
hydroxyapatite (HA20), 40&#8239;nm hydroxyapatite (HA40), nano-Fe3O4
(nFe3O4) and nano-zerovalent iron [nFe]) on the biomass, arsenic uptake,
and enzyme activities in seedlings of the rice cultivars T705 and X24.
Compared with the control, the addition of different nanomaterials
increased seedling growth, with X24 rice growing better than T705 rice.
Nanomaterials effectively reduced arsenic uptake in T705 rice seedlings
under low and high arsenic concentrations; however, they were only
effective at lower arsenic concentrations in X24 seedlings. nFe3O4 and nFe
performed better than other nanomaterials in preventing arsenic from being
transported to the aboveground parts of the rice seedlings. Different
nanomaterials obviously influenced enzyme activities in the T705 seedlings
at low arsenic concentrations (&le; 0.8&#8239;mg&#8239;L-1). High-quality
and multilayer graphene oxide decreased enzyme activities in the
aboveground parts of the T705 seedlings, whereas, HA20 and HA40 increased
the enzyme activities. nFe3O4 and nFe also reduced the effect of
antioxidants in the aboveground parts of the T705 seedlings. Nanomaterials
effectively reduced the arsenic uptake of T705 and X24 rice seedlings at
low arsenic concentrations.
KW - Arsenic
KW - Enzyme activity
KW - Nanomaterial
KW - Rice cultivar
KW - Uptake
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180527
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180521
STAT- In-Process
DOCNO- medline/29753827

81 - TOXLINE
TI - Effect of nutritional status on arsenic and smokeless tobacco induced
genotoxicity, sperm abnormality and oxidative stress in mice in vivo.
AU - Das S
AD - Department of Life Science and Bioinformatics, Molecular and Cell Biology
Laboratory, Assam University, Silchar, 788011, India.
AU - Langthasa P
AD - Department of Life Science and Bioinformatics, Molecular and Cell Biology
Laboratory, Assam University, Silchar, 788011, India.
AU - Barhoi D
AD - Department of Life Science and Bioinformatics, Molecular and Cell Biology
Laboratory, Assam University, Silchar, 788011, India.
AU - Upadhaya P
AD - Department of Life Science and Bioinformatics, Molecular and Cell Biology
Laboratory, Assam University, Silchar, 788011, India.
AU - Giri S
AD - Department of Life Science and Bioinformatics, Molecular and Cell Biology
Laboratory, Assam University, Silchar, 788011, India.
SO - Environ Mol Mutagen. 2018, Mar 22. [Environmental and molecular
mutagenesis]
AB - BACKGROUND: Recently, high concentrations of arsenic have been documented
in ground waters of Southern Assam, India. Indiscriminate smokeless
tobacco consumption is a common practice in this region. Correlation
between nutritional status and arsenic and smokeless tobacco-induced
health effects has not been taken up in humans or other test systems.
AB - METHODS: Mice were divided into groups based on protein (casein) content
in the diet: High protein (40%), optimum protein (20%), and low protein
(5%). Simultaneous chronic exposure (90 days) to arsenic and smokeless
tobacco (sadagura) orally was given to evaluate the extent of the
cytological and genotoxicological damage. Micronucleus assay and Comet
assay of the femur bone marrow cells were conducted. Germ cell toxicity
was evaluated by recording the sperm head abnormalities and total sperm
count. Cell cycle analysis was performed in femur bone marrow cells using
flow cytometer. Hepatic, renal, and intestinal tissues were analyzed for
various oxidative stress evaluations. Histological examination of liver
and kidney was performed.
AB - RESULTS: Notably, high protein diet groups had lower arsenic and sadagura
induced genotoxicity, germ cell abnormalities and oxidative stress as
compared to optimum protein and low protein diet counterparts.
AB - CONCLUSION: Our study indicates that sufficient levels of dietary protein
appear to reduce the long-term arsenic and smokeless tobacco-induced
toxicity in mice test system, as compared to lower or deficient amount of
protein in the diet. This observation has implications and invites further
studies especially epidemiological studies in the human population exposed
to arsenic in South East Asian countries. Environ. Mol. Mutagen., 2018.
&copy; 2018 Wiley Periodicals, Inc.
KW - arsenic
KW - comet assay
KW - diet protein
KW - oxidative damage
KW - smokeless tobacco
KW - sperm head abnormality assay
LA - eng
IS - 1098-2280 (Electronic)
PT - Journal Article
TA - Environ Mol Mutagen
YR - 2018
DATE- 20180323
CI - &copy; 2018 Wiley Periodicals, Inc.
CITO- NLM
CS - United States
FJT - Environmental and molecular mutagenesis
EDAT- 20180322
STAT- Publisher
DOCNO- medline/29569270

82 - TOXLINE
TI - Arsenic-induced carcinogenesis: the impact of miRNA dysregulation.
AU - Cardoso APF
AD - Department of Pharmacology and Toxicology, University of Louisville,
Louisville, KY, 40202, U.S.A.
AU - Al-Eryani L
AD - DNA Repair Section, Laboratory of Cancer Biology and Genetics, Center for
Cancer Research, National Cancer Institute, National Institutes of Health, 37
Convent Drive, Room 4002, Bethesda, MD 20892-4262, U.S.A.
AU - States JC
AD - Department of Pharmacology and Toxicology, University of Louisville,
Louisville, KY, 40202, U.S.A.
SO - Toxicol Sci. 2018, May 28. [Toxicological sciences : an official journal
of the Society of Toxicology]
AB - Arsenic is a toxic metalloid widely present in the earth's crust, and is a
proven human carcinogen. Chronic arsenic exposure mainly through drinking
water causes skin, lung and urinary bladder cancers, and is associated
with liver, prostate and kidney cancers, cardiovascular and neurological
disorders, and diabetes. Several modes of action have been suggested in
arsenic carcinogenesis. However, the molecular etiology of arsenic induced
cancer remains unclear. Recent evidence clearly indicates that gene
expression modifications induced by arsenic may involve epigenetic
alterations, including miRNA dysregulation. Many miRNAs have been
implicated in different human cancers as a consequence of losses and or
gains of miRNA function that contribute to cancer development. Progress in
identifying miRNA dysregulation induced by arsenic has been made using
different approaches and models. The present review discusses the recent
data regarding dysregulated expression of miRNA in arsenic-induced
malignant transformation in vitro, gaps in current understanding and
deficiencies in current models for arsenic-induced carcinogenesis, and
future directions of research that would improve our knowledge regarding
the mechanisms involved in arsenic-induced carcinogenesis.
LA - eng
IS - 1096-0929 (Electronic)
PT - Journal Article
TA - Toxicol Sci
YR - 2018
DATE- 20180530
CITO- NLM
CS - United States
FJT - Toxicological sciences : an official journal of the Society of Toxicology
EDAT- 20180528
STAT- Publisher
DOCNO- medline/29846715

83 - TOXLINE
TI - Effects of arsenic toxicity beyond epigenetic modifications.
AU - Bj�rklund G
AD - Council for Nutritional and Environmental Medicine, Toften 24, 8610, Mo i
Rana, Norway. bjorklund@conem.org.
AU - Aaseth J
AD - Innlandet Hospital Trust and Inland Norway University of Applied Sciences,
Elverum, Norway.
AU - Chirumbolo S
AD - Department of Neurological and Movement Sciences, University of Verona,
Verona, Italy.
AU - Urbina MA
AD - Departamento de Zoolog�a, Facultad de Ciencias Naturales y Oceanogr�ficas,
Universidad de Concepci�n, Casilla 160-C, Concepci�n, Chile.
AU - Uddin R
AD - Department of Pharmacy, Stamford University Bangladesh, Dhaka, Bangladesh.
SO - Environ Geochem Health. 2018, Jun; 40(3):955-965. [Environmental
geochemistry and health]
AB - Worldwide chronic arsenic (As) poisoning by arsenic-contaminated
groundwater is one of the most threatening public health problems. Chronic
inorganic As (inAs) exposure has been associated with various forms of
cancers and numerous other pathological effects in humans, collectively
known as arsenicosis. Over the past decade, evidence indicated that
As-induced epigenetic modifications have a role in the adverse effects on
human health. The main objective of this article is to review the evidence
on epigenetic modifications induced by arsenicals. The epigenetic
components play a crucial role in the regulation of gene expression, at
both transcriptional and posttranscriptional levels. We synthesized the
large body of existing research on arsenic exposure and epigenetic
mechanisms of health outcomes with an emphasis on recent publications.
Changes in patterns of DNA methylation, histone posttranslational
modifications, and microRNAs have been repeatedly observed after inAs
exposure in laboratory studies and in studies of human populations. Such
alterations have the potential to disturb cellular homeostasis, resulting
in the modulation of key pathways in the As-induced carcinogenesis. The
present article reviews recent data on As-induced epigenetic effects and
concludes that it is time for heightened awareness of pathogenic arsenic
exposure, particularly for pregnant women and children, given the
potential for a long-lasting disturbed cellular homeostasis.
KW - Arsenic
KW - Arsenic health effects
KW - Cancer
KW - Chronic arsenic exposure
KW - Drinking water
KW - Human development
KW - Skin lesions
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
PT - Review
TA - Environ Geochem Health
YR - 2018
DATE- 20180525
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20170508
STAT- In-Process
CM - Cites: Cancer Lett. 2008 Sep 18;268(2):325-30 (medline /18513855)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2012 Dec;21(12):2252-60 (medline
/23064002)
CM - Cites: Environ Health Perspect. 2013 Aug;121(8):971-7 (medline /23757598)
CM - Cites: Sci Total Environ. 2015 Jun 1;517:232-45 (medline /25748724)
CM - Cites: Food Chem Toxicol. 2010 Apr;48(4):1032-9 (medline /20096321)
CM - Cites: Nat Rev Cancer. 2004 Feb;4(2):143-53 (medline /14732866)
CM - Cites: Cancer Res. 2006 Nov 15;66(22):10843-8 (medline /17108120)
CM - Cites: Epigenomics. 2010 Feb;2(1):87-104 (medline /20514360)
CM - Cites: Arch Toxicol. 2014 May;88(5):1043-67 (medline /24691704)
CM - Cites: Nature. 2007 May 24;447(7143):433-40 (medline /17522677)
CM - Cites: Sci Total Environ. 2006 Nov 1;370(2-3):294-301 (medline /16875714)
CM - Cites: Environ Sci Technol. 2001 Jul 1;35(13):2621-6 (medline /11452583)
CM - Cites: Am J Epidemiol. 2001 Mar 1;153(5):411-8 (medline /11226969)
CM - Cites: Environ Mol Mutagen. 2014 Apr;55(3):196-208 (medline /24327377)
CM - Cites: Toxicol Appl Pharmacol. 2009 Mar 15;235(3):338-50 (medline
/19168087)
CM - Cites: Toxicol Appl Pharmacol. 2009 Dec 15;241(3):294-302 (medline
/19732783)
CM - Cites: Biomed Res Int. 2015;2015:892579 (medline /26295053)
CM - Cites: J Pharmacol Exp Ther. 1997 Jul;282(1):192-200 (medline /9223554)
CM - Cites: Metallomics. 2012 Jan;4(1):91-100 (medline /22028001)
CM - Cites: Environ Toxicol Pharmacol. 2013 Jul;36(1):73-9 (medline /23619517)
CM - Cites: Arch Toxicol. 2011 Jun;85(6):653-61 (medline /20978746)
CM - Cites: Nucleic Acids Res. 1983 Mar 11;11(5):1389-404 (medline /6402762)
CM - Cites: Environ Health Perspect. 2012 Jul;120(7):1061-6 (medline /22466225)
CM - Cites: Hypertension. 1999 Jan;33(1):74-8 (medline /9931084)
CM - Cites: Sci Prog. 1947 Jul;35(139):396-416 (medline /20256237)
CM - Cites: Sci Total Environ. 2012 Jul 1;429:2-35 (medline /21959248)
CM - Cites: Cell. 1999 Oct 29;99(3):247-57 (medline /10555141)
CM - Cites: Am J Clin Nutr. 2007 Oct;86(4):1179-86 (medline /17921400)
CM - Cites: Mol Biol Int. 2011;2011:718974 (medline /22091411)
CM - Cites: J Trace Elem Med Biol. 2015;31:260-6 (medline /25457281)
CM - Cites: Environ Int. 2009 Apr;35(3):466-72 (medline /18809211)
CM - Cites: Folia Biol (Praha). 2010;56(3):83-96 (medline /20653993)
CM - Cites: Arch Toxicol. 2005 Apr;79(4):183-91 (medline /15526190)
CM - Cites: J Trace Elem Med Biol. 2015;31:237-48 (medline /25660323)
CM - Cites: Bull World Health Organ. 2012 Nov 1;90(11):839-46 (medline
/23226896)
CM - Cites: Environ Geochem Health. 2016 Apr;38(2):339-51 (medline /26169729)
CM - Cites: Sci Total Environ. 2014 Aug 1;488-489:562-9 (medline /24262873)
CM - Cites: Virchows Arch. 2008 Jan;452(1):1-10 (medline /18040713)
CM - Cites: J Can Res Updates. 2012 Aug 21;1:57-68 (medline /23487506)
CM - Cites: Toxicol Appl Pharmacol. 2010 Mar 15;243(3):292-9 (medline
/19932709)
CM - Cites: Genome Biol. 2006;7(5):217 (medline /16689998)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):268-71 (medline
/15276405)
CM - Cites: Environ Sci Technol. 2016 Jun 21;50(12 ):6556-64 (medline
/27223406)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1270-8 (medline
/17548696)
CM - Cites: Toxicol Appl Pharmacol. 2008 Jul 1;230(1):33-40 (medline /18387645)
CM - Cites: Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16916-21 (medline
/12481029)
CM - Cites: Environ Health Perspect. 2011 May;119(5):719-24 (medline /21147604)
CM - Cites: Int J Mol Sci. 2011;12(4):2351-82 (medline /21731446)
CM - Cites: Nihon Eiseigaku Zasshi. 2015;70(3):186-96 (medline /26411936)
CM - Cites: Toxicol Sci. 2011 May;121(1):110-22 (medline /21292642)
CM - Cites: Genome Res. 2009 Jan;19(1):92-105 (medline /18955434)
CM - Cites: J Biochem Mol Toxicol. 2013 Feb;27(2):106-15 (medline /23315758)
CM - Cites: Oman Med J. 2011 May;26(3):207 (medline /22043419)
CM - Cites: Saudi J Kidney Dis Transpl. 2015 May-Jun;26(3):611-2 (medline
/26022042)
CM - Cites: Epigenetics. 2013 May;8(5):464-76 (medline /23644490)
CM - Cites: Eur Respir J. 2012 May;39(5):1076-83 (medline /22088973)
CM - Cites: J Toxicol Clin Toxicol. 2001;39(7):683-700 (medline /11778666)
CM - Cites: Cancer Causes Control. 2008 Oct;19(8):829-39 (medline /18351295)
CM - Cites: Environ Mol Mutagen. 2015 Jan;56(1):60-9 (medline /25156000)
CM - Cites: Cell. 2007 Feb 23;128(4):693-705 (medline /17320507)
CM - Cites: Toxicology. 2003 Apr 15;186(1-2):33-50 (medline /12604169)
CM - Cites: Toxicol Appl Pharmacol. 2014 Oct 1;280(1):53-9 (medline /25062773)
CM - Cites: Toxicol Appl Pharmacol. 2010 Feb 1;242(3):352-62 (medline
/19914269)
CM - Cites: Metallomics. 2012 Nov;4(11):1167-75 (medline /23073540)
CM - Cites: Chem Res Toxicol. 2011 Feb 18;24(2):165-7 (medline /21291286)
CM - Cites: Biomed Res Int. 2014;2014:683124 (medline /24949461)
CM - Cites: Water Res. 2013 Oct 1;47(15):5801-18 (medline /23899878)
CM - Cites: Environ Pollut. 2006 Jan;139(1):95-106 (medline /16009476)
CM - Cites: Environ Int. 2014 Aug;69:148-58 (medline /24853282)
CM - Cites: J Occup Environ Med. 2003 Mar;45(3):241-8 (medline /12661181)
CM - Cites: Genes Dev. 2011 May 15;25(10):1010-22 (medline /21576262)
CM - Cites: Environ Health Perspect. 2011 Jan;119(1):113-8 (medline /21205583)
CM - Cites: Epidemiology. 2005 Jan;16(1):82-6 (medline /15613949)
CM - Cites: N Engl J Med. 1998 Nov 5;339(19):1341-8 (medline /9801394)
CM - Cites: J Environ Pathol Toxicol Oncol. 2015;34(1):63-84 (medline
/25746832)
CM - Cites: Am J Epidemiol. 1998 Jul 15;148(2):198-203 (medline /9676702)
CM - Cites: Environ Health Perspect. 2005 Mar;113(3):250-4 (medline /15743710)
CM - Cites: J Biol Chem. 2003 Apr 11;278(15):13183-91 (medline /12547826)
CM - Cites: Chem Res Toxicol. 2001 Apr;14(4):371-8 (medline /11304125)
CM - Cites: Environ Health Perspect. 2005 Dec;113(12):1683-8 (medline
/16330347)
CM - Cites: Lancet. 2010 Jul 24;376(9737):252-8 (medline /20646756)
CM - Cites: Sci Total Environ. 2007 Jan 1;372(2-3):413-25 (medline /17081593)
CM - Cites: Toxicol Appl Pharmacol. 2009 Apr 15;236(2):131-41 (medline
/19371612)
CM - Cites: Mamm Genome. 2009 Sep-Oct;20(9-10):573-80 (medline /19697081)
CM - Cites: J Trace Elem Med Biol. 2015;31:209-13 (medline /24837610)
CM - Cites: Epigenetics. 2014 May;9(5):774-82 (medline /24525453)
CM - Cites: Toxicol Appl Pharmacol. 2005 Aug 15;206(3):299-308 (medline
/16039941)
CM -Cites: Environ Int. 2004 May;30(3):383-7 (medline /14987870)
CM -Cites: Oncogene. 2001 May 28;20(24):3166-73 (medline /11420733)
CM -Cites: Rev Environ Health. 2010 Jul-Sep;25(3):193-220 (medline /21038756)
CM -Cites: Environ Int. 2015 Aug;81:8-17 (medline /25898228)
CM -Cites: Int J Environ Res Public Health. 2012 Dec 07;9(12):4522-36 (medline
/23222207)
CM - Cites: Environ Health Perspect. 2015 May;123(5):451-7 (medline /25575156)
CM - Cites: Sci Rep. 2013;3:2195 (medline /23873074)
CM - Cites: Environ Health Perspect. 2011 Jun;119(6):771-7 (medline /21193388)
DOCNO- medline/28484874

84 - TOXLINE
TI - Isolation and identification of the native population bacteria for
bioremediation of high levels of arsenic from water resources.
AU - Jebelli MA
AD - Department of Environmental Health Engineering, Environmental Health Research
Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
AU - Maleki A
AD - Department of Environmental Health Engineering, Environmental Health Research
Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. Electronic
address: maleki43@yahoo.com.
AU - Amoozegar MA
AD - Extremophiles Laboratory, Department of Microbiology, Faculty of Biology and
Center of Excellence in Phylogeny of Living Organisms, College of Science,
University of Tehran, Iran.
AU - Kalantar E
AD - Dietary Supplement and Probiotic Research Center, Alborz University of
Medical Sciences, Karaj, Iran. Electronic address: enayat.kalantar66@gmail.com.
AU - Gharibi F
AD - Department of Environmental Health Engineering, Environmental Health Research
Center, Kurdistan University of Medical Sciences, Sanandaj, Iran.
AU - Darvish N
AD - Graduate School of Environment and Energy, Science and Research Branch,
Islamic Azad University,Tehran, Iran.
AU - Tashayoe H
AD - Department of Environmental Health Engineering, Faculty of Health, Water
Purification Research Center, Tehran Medical Sciences Branch Islamic Azad
University, Tehran, Iran.
SO - J Environ Manage. 2018, Apr 15; 212:39-45. [Journal of environmental
management]
AB - Health of millions of people is threatened by the risk of drinking
arsenic-contaminated water worldwide. Arsenic naturally conflicts with the
concept of life, but recent studies showed that some microorganisms use
toxic minerals as the source of energy. Hence, the researchers should
consider the development of cost-effective and highly productive
procedures to remove arsenic. The current study was conducted on a native
bacterial population of Seyed-Jalaleddin Spring Kurdistan, Iran.
Accordingly, the arsenic amount in water samples was measured
> 500&#8239;&mu;g/L by the two field and in vitro methods. Water
samples were transferred to laboratory and cultured on chemically defined
medium (CDM) with arsenic salts. A total of 14 native arsenic-resistant
bacterial strains were isolated and after providing pure culture and
performing biochemical tests, the isolates were identified using
polymerase chain reaction (PCR) and 16s rRNA genomic sequencing. The
potential of bacterial strains for the biotransformation of arsenic was
assessed by the qualitative assessment of AgNO3 method and efficiency of
arsenic speciation was determined for the first time by silver
diethyldithiocarbamate (SDDC) method with an error of less than 5%. Among
the isolated strains, only strain As-11 and strain As-12 showed arsenic
transformation characteristics and were registered in NCBI database by the
access numbers KY119262 and KY119261, respectively. Results of the current
study indicated that strain As-11 had the potential of biotransformation
of As(V) to As(III) and vice versa with the efficiency of 78% and 48%,
respectively. On the other hand, strain As-12 had the potential for
biotransformation of As(V) to As(III) and vice versa with the efficiency
of 28% and 45%, respectively.
KW - Arsenic
KW - Biotransformation
KW - SDDC
KW - Water resource
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180222
STAT- In-Process
DOCNO- medline/29427940

85 - TOXLINE
TI - Two facets of world arsenic problem solution: crop poisoning restriction
and enforcement of phytoremediation.
AU - Kofro&#328;ov� M
AD - Department of Experimental Plant Biology, Faculty of Science, Charles
University, Vini&#269;n� 5, 128 43, Prague 2, Czech Republic.
AU - Ma&scaron;kov� P
AD - Department of Experimental Plant Biology, Faculty of Science, Charles
University, Vini&#269;n� 5, 128 43, Prague 2, Czech Republic.
petra.maskova@natur.cuni.cz.
AU - Lipavsk� H
AD - Department of Experimental Plant Biology, Faculty of Science, Charles
University, Vini&#269;n� 5, 128 43, Prague 2, Czech Republic.
SO - Planta. 2018, May 07. [Planta]
AB - MAIN CONCLUSION: This review provides insights into As toxicity in plants
with focus on photosynthesis and sugar metabolism as important arsenic
targets and simultaneously defence tools against accompanying oxidative
stress. Heavy metal contamination is a great problem all over the world.
Arsenic, a metalloid occurring naturally in the Earth's crust, also
massively spreads out in the environment by human activities. Its
accumulation in crops poses a severe health risk to humans and animals.
Besides the restriction of human-caused contamination, there are two basic
ways how to cope with the problem: first, to limit arsenic accumulation in
harvestable parts of the crops; second, to make use of some arsenic
hyperaccumulating plants for phytoremediation of contaminated soils and
waters. Progress in the use of both strategies depends strongly on the
level of our knowledge on the physiological and morphological processes
resulting from arsenic exposure. Arsenic uptake is mediated preferentially
by P and Si transporters and its accumulation substantially impairs plant
metabolism at numerous levels including damages through oxidative stress.
Rice is a predominantly studied crop where substantial progress has been
made in understanding of the mechanisms of arsenic uptake, distribution,
and detoxification, though many questions still remain. Full exploitation
of plant potential for soil and water phytoremediations also requires deep
understanding of the plant response to this toxic metalloid. The aim of
this review is to summarize data regarding the effect of arsenic on plant
physiology with a focus on mechanisms providing increased arsenic
tolerance and/or hyperaccumulation. The emphasis is placed on the topic
unjustifiably neglected in the previous reviews - i.e.,
carbohydrate metabolism, tightly connected to photosynthesis, and beside
others involved in plant ability to cope with arsenic-induced oxidative
and nitrosative stresses.
KW - Antioxidant
KW - Arsenic
KW - Carbohydrates
KW - Nitrosative stress
KW - Oxidative stress
KW - Phytoremediation
LA - eng
IS - 1432-2048 (Electronic)
PT - Journal Article
PT - Review
TA - Planta
YR - 2018
DATE- 20180619
CITO- NLM
CS - Germany
FJT - Planta
EDAT- 20180507
STAT- Publisher
CM - Cites: J Proteomics. 2014 Jun 13;105:46-57 (medline /24508335)
CM - Cites: Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9931-5 (medline
/18626020)
CM - Cites: Ecotoxicol Environ Saf. 2009 Feb;72(2):626-34 (medline /18262648)
CM - Cites: New Phytol. 2007;174(2):311-21 (medline /17388894)
CM - Cites: Curr Opin Plant Biol. 2009 Jun;12(3):364-72 (medline /19501016)
CM - Cites: New Phytol. 2014 Mar;201(4):1251-62 (medline /24206613)
CM - Cites: ISME J. 2016 Jan;10 (1):197-209 (medline /26151644)
CM - Cites: J Exp Bot. 2013 Jan;64(1):303-15 (medline /23162117)
CM - Cites: Plant Physiol. 2000 Apr;122(4):1171-7 (medline /10759512)
CM - Cites: J Hazard Mater. 2010 Mar 15;175(1-3):896-914 (medline /19944530)
CM - Cites: Plant Cell. 2010 Jun;22(6):2045-57 (medline /20530755)
CM - Cites: Plant Physiol. 1993 Aug;102(4):1163-1169 (medline /12231893)
CM - Cites: Protoplasma. 2011 Jul;248(3):565-77 (medline /20857150)
CM - Cites: Annu Rev Plant Physiol Plant Mol Biol. 1998 Jun;49:643-668 (medline
/15012249)
CM - Cites: Plant J. 2006 Mar;45(6):917-29 (medline /16507083)
CM - Cites: Chemosphere. 2005 Oct;61(2):293-301 (medline /16168752)
CM - Cites: PLoS One. 2017 Mar 15;12 (3):e0173681 (medline /28296918)
CM - Cites: Protoplasma. 2011 Oct;248(4):805-15 (medline /21188438)
CM - Cites: Annu Rev Plant Biol. 2010;61:535-59 (medline /20192735)
CM - Cites: Chemosphere. 2009 Feb;74(5):688-702 (medline /18996570)
CM - Cites: Plant Physiol. 2002 Nov;130(3):1552-61 (medline /12428020)
CM - Cites: Biol Trace Elem Res. 2012 Jun;146(3):360-8 (medline /22124861)
CM - Cites: Environ Pollut. 2009 Mar;157(3):887-94 (medline /19073356)
CM - Cites: Talanta. 2002 Aug 16;58(1):181-8 (medline /18968744)
CM - Cites: Physiol Plant. 2016 Jun;157(2):135-46 (medline /26853807)
CM - Cites: Nat Plants. 2015 Dec 21;2(1):15202 (medline /27004129)
CM - Cites: Chemosphere. 2007 Apr;67(6):1072-9 (medline /17239924)
CM - Cites: Environ Sci Pollut Res Int. 2011 Aug;19(7):3046-53 (medline
/22367495)
CM - Cites: Plant Physiol. 2004 Oct;136(2):3198-208 (medline /15448194)
CM - Cites: Plant Physiol Biochem. 2016 Jan;98:119-27 (medline /26686284)
CM - Cites: J Exp Bot. 2013 Apr;64(6):1439-49 (medline /23564957)
CM - Cites: Plant Physiol. 2011 Sep;157(1):498-508 (medline /21715673)
CM - Cites: J Exp Bot. 2009;60(1):9-18 (medline /19036839)
CM - Cites: Trends Plant Sci. 2012 Mar;17(3):155-62 (medline /22257759)
CM - Cites: Plant Cell Rep. 2007 Nov;26(11):2027-38 (medline /17653721)
CM - Cites: Environ Pollut. 2017 Apr;223:230-237 (medline /28108165)
CM - Cites: Front Plant Sci. 2014 Nov 04;5:592 (medline /25408694)
CM - Cites: Plant Physiol Biochem. 2013 Oct;71:307-14 (medline /24007815)
CM - Cites: Proc Natl Acad Sci U S A. 2006 Apr 4;103(14 ):5413-8 (medline
/16567632)
CM - Cites: Environ Pollut. 2017 May;224:125-135 (medline /28214191)
CM - Cites: J Biol Chem. 2009 Jan 23;284(4):2114-20 (medline /19029297)
CM - Cites: Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15699-704 (medline
/25331872)
CM - Cites: Ann Bot. 2003 Jan;91 Spec No:179-94 (medline /12509339)
CM - Cites: Front Plant Sci. 2016 Jun 14;7:817 (medline /27379117)
CM - Cites: New Phytol. 2016 Jan;209(2):762-72 (medline /26010225)
CM - Cites: Ecotoxicol Environ Saf. 2001 Jun;49(2):111-21 (medline /11386724)
CM - Cites: Cell Mol Life Sci. 2009 Jul;66(14):2329-39 (medline /19350206)
CM - Cites: Anal Chim Acta. 2010 Jan 11;657(2):83-99 (medline /20005319)
CM - Cites: New Phytol. 2009 Mar;181(4):777-94 (medline /19207683)
CM - Cites: Planta. 2015 May;241(5):1109-18 (medline /25600998)
CM - Cites: Ecotoxicol Environ Saf. 2017 May;139:344-351 (medline /28187398)
CM - Cites: J Environ Sci (China). 2007;19(6):725-32 (medline /17969647)
CM - Cites: Protoplasma. 2012 Jul;249(3):725-36 (medline /21901307)
CM - Cites: Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16113-8 (medline
/14671332)
CM - Cites: Plant Cell Environ. 2017 Apr;40(4):462-472 (medline /26754426)
CM - Cites: Plant Physiol. 2010 Jan;152(1):309-19 (medline /19880610)
CM - Cites: Plant Physiol. 2008 Jul;147(3):1251-63 (medline /18502973)
CM - Cites: Ecotoxicol Environ Saf. 2017 Apr;138:199-205 (medline /28061413)
CM - Cites: Biochemistry. 2012 Jul 10;51(27):5476-85 (medline /22712827)
CM - Cites: Plant Physiol Biochem. 2017 Mar;112:74-86 (medline /28049059)
CM - Cites: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2075-80 (medline
/16452170)
CM - Cites: Plant Physiol. 2009 Aug;150(4):2071-80 (medline /19542298)
CM - Cites: New Phytol. 2016 Jan;209(2):746-61 (medline /26372374)
CM - Cites: J Exp Bot. 2013 Feb;64(4):1025-38 (medline /23349141)
CM - Cites: J Hazard Mater. 2013 Nov 15;262:1123-31 (medline /22917495)
CM - Cites: J Mol Model. 2012 Sep;18(9):4249-62 (medline /22562211)
CM - Cites: J Plant Physiol. 2004 Jul;161(7):867-72 (medline /15310076)
CM - Cites: J Biotechnol. 2002 Nov 13;99(3):259-78 (medline /12385714)
CM - Cites: Front Plant Sci. 2017 Apr 19;8:516 (medline /28469622)
CM - Cites: Protoplasma. 2015 Sep;252(5):1217-29 (medline /25586108)
CM - Cites: Plant Cell. 2007 Mar;19(3):1123-33 (medline /17400898)
CM - Cites: Plant Cell. 2013 Aug;25(8):2944-57 (medline /23922208)
CM - Cites: Environ Pollut. 2016 Sep;216:215-222 (medline /27263113)
CM - Cites: Plant Physiol. 2010 Nov;154(3):1505-13 (medline /20870777)
CM - Cites: Environ Pollut. 2017 Aug;227:569-577 (medline /28501771)
CM - Cites: Ecotoxicol Environ Saf. 2009 May;72(4):1102-10 (medline /19013643)
CM - Cites: J Hazard Mater. 2017 May 15;330:68-75 (medline /28212511)
CM - Cites: Ecotoxicol Environ Saf. 2013 Apr;90:28-34 (medline /23321366)
CM - Cites: Mol Plant. 2015 May;8(5):722-33 (medline /25732589)
CM - Cites: Trends Biotechnol. 2007 Apr;25(4):158-65 (medline /17306392)
CM - Cites: PLoS One. 2012;7(8):e42408 (medline /22879969)
CM - Cites: Annu Rev Plant Physiol Plant Mol Biol. 1998 Jun;49:249-279 (medline
/15012235)
CM - Cites: Sci Total Environ. 2002 Feb 4;284(1-3):27-35 (medline /11846172)
CM -Cites: J Hazard Mater. 2017 Jun 5;331:246-256 (medline /28273574)
CM -Cites: Sci Rep. 2014 Jul 22;4:5784 (medline /25048298)
CM -Cites: Physiol Mol Biol Plants. 2015 Jul;21(3):453-8 (medline /26261411)
CM -Cites: Chemosphere. 2017 May;175:192-199 (medline /28222373)
CM -Cites: Nat Commun. 2014 Aug 07;5:4617 (medline /25099865)
CM -Cites: BMC Biol. 2008 Jun 10;6:26 (medline /18544156)
CM -Cites: Environ Sci Pollut Res Int. 2016 Jun;23 (12 ):11864-75 (medline
/26957429)
CM - Cites: J Hazard Mater. 2013 Nov 15;262:1230-6 (medline /22947180)
CM - Cites: Plant J. 2015 Jun;82(5):822-39 (medline /25891826)
CM - Cites: Plant Physiol. 2000 Jul;123(3):825-32 (medline /10889232)
CM - Cites: Environ Sci Technol. 2011 Jul 15;45(14):6080-7 (medline /21692537)
CM - Cites: Transgenic Res. 2012 Dec;21(6):1265-77 (medline /22350764)
CM - Cites: J Exp Bot. 2006;57(3):449-59 (medline /16397003)
CM - Cites: Environ Sci Technol. 2002 Mar 1;36(5):962-8 (medline /11918027)
CM - Cites: Front Plant Sci. 2017 Mar 01;8:268 (medline /28298917)
CM - Cites: Environ Sci Pollut Res Int. 2012 Sep;19(8):3506-15 (medline
/22529007)
CM - Cites: Chemosphere. 2011 Apr;83(5):633-46 (medline /21435676)
CM - Cites: Plant Signal Behav. 2009 Oct;4(10):920-3 (medline /19826215)
CM - Cites: New Phytol. 2011 Oct;192(1):87-98 (medline /21658183)
CM - Cites: Plant Physiol. 2006 Aug;141(4):1544-54 (medline /16766666)
CM - Cites: Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21187-92 (medline
/21078981)
CM - Cites: Ecotoxicol Environ Saf. 2017 Apr;138:47-55 (medline /28006731)
CM - Cites: Plant J. 2004 Aug;39(4):629-42 (medline /15272879)
CM - Cites: Plant Cell Physiol. 2009 Feb;50(2):265-79 (medline /19112080)
CM - Cites: Plant Cell Environ. 2009 Jul;32(7):851-8 (medline /19236608)
CM - Cites: Environ Sci Technol. 2006 Aug 15;40(16):5010-4 (medline /16955900)
CM - Cites: PLoS Biol. 2014 Dec 02;12(12):e1002009 (medline /25464340)
CM - Cites: Nature. 2001 Feb 1;409(6820):579 (medline /11214308)
CM - Cites: Biosci Biotechnol Biochem. 2011;75(3):522-30 (medline /21389618)
CM - Cites: Environ Sci Technol. 2017 Feb 7;51(3):1224-1230 (medline /28076949)
CM - Cites: Environ Pollut. 2012 Jul;166:136-43 (medline /22504427)
DOCNO- medline/29736625

86 - TOXLINE
TI - Arsenic Induces Thioredoxin 1 and Apoptosis in Human Liver HHL-5 Cells.
AU - Li Y
AD - Center for Endemic Disease Control, Chinese Center for Disease Control and
Prevention, Key Laboratory of Etiologic Epidemiology of Education Bureau of
Heilongjiang Province and Ministry of Health, Harbin Medical University, Harbin,
150081, China.
AU - Zhang Y
AD - Center for Endemic Disease Control, Chinese Center for Disease Control and
Prevention, Key Laboratory of Etiologic Epidemiology of Education Bureau of
Heilongjiang Province and Ministry of Health, Harbin Medical University, Harbin,
150081, China.
AU - Gao Y
AD - Center for Endemic Disease Control, Chinese Center for Disease Control and
Prevention, Key Laboratory of Etiologic Epidemiology of Education Bureau of
Heilongjiang Province and Ministry of Health, Harbin Medical University, Harbin,
150081, China.
AU - Zhang W
AD - Center for Endemic Disease Control, Chinese Center for Disease Control and
Prevention, Key Laboratory of Etiologic Epidemiology of Education Bureau of
Heilongjiang Province and Ministry of Health, Harbin Medical University, Harbin,
150081, China.
AU - Cui X
AD - Advanced Institute for Medical Sciences, Dalian Medical University, Dalian,
116044, China.
AU - Liu J
AD - Center for Endemic Disease Control, Chinese Center for Disease Control and
Prevention, Key Laboratory of Etiologic Epidemiology of Education Bureau of
Heilongjiang Province and Ministry of Health, Harbin Medical University, Harbin,
150081, China.
AU - Wei Y
AD - Department of Community Medicine, Mercer University School of Medicine,
Macon, GA, 31207, USA. wei_yd@mercer.edu.
SO - Biol Trace Elem Res. 2018, Feb; 181(2):234-241. [Biological trace element
research]
AB - To further characterize the mechanisms underlying liver toxicity induced
by arsenic, we examined in this study the effect of arsenic on thioredoxin
(Trx) and the apoptotic signaling pathways in human liver HHL-5 cells. The
cells were treated with 0, 2, 5, and 10 &mu;M of sodium arsenite for
24 h, and the changes of Trx1 and thioredoxin reductase (TrxR1) as
well as intracellular ROS and apoptosis were examined. A
concentration-dependent increase in mRNA and protein levels of Trx1 and
TrxR1 was observed in arsenic-treated cells. Intracellular ROS levels and
apoptosis were also significantly increased in a concentration-dependent
manner. In line with this, protein levels of Bax and cytochrome C were
increased and Bcl-2 was decreased by arsenic treatments. Increases in
caspase 3 activity were observed. These results indicate that Trx is
involved in arsenic-induced liver cell injury, probably through the
apoptotic signaling pathway. However, further studies are needed to
elucidate on these findings.
KW - Apoptosis
KW - Arsenic
KW - HHL-5 liver cells
KW - Liver injury
KW - Oxidative stress
KW - Thioredoxin
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180114
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170517
STAT- In-Process
DOCNO- medline/28512695

87 - TOXLINE
TI - Improved biotransformation of arsenic by arsenite oxidase - Chitosan
nanoparticle conjugates.
AU - Pandey N
AD - Department of Biotechnology, Guru Ghasidas Vishwavidyalaya (A Central
University), Bilaspur, Chhattisgarh 495009, India.
AU - Bhatt R
AD - Department of Biotechnology, Guru Ghasidas Vishwavidyalaya (A Central
University), Bilaspur, Chhattisgarh 495009, India. Electronic address:
dr.renubhatt@yahoo.com.
SO - Int J Biol Macromol. 2018, Jan; 106:258-265. [International journal of
biological macromolecules]
AB - Recent developments in the potential use of nanoparticles as carriers of
enzyme have attracted great attention. In the present study, arsenite
oxidase (AOase) enzyme capable of transforming the more toxic arsenite
[As(III)] to the less toxic arsenate [As(V)] was extracted from an arsenic
resistant bacterium (Exiguobacterium sp. As-9) and partially purified.
Chitosan nanoparticles were prepared on the basis of ionic gelation of
chitosan with tripolyphosphate (TPP) anions. The purified AOase was
immobilized efficiently by physical adsorption on to chitosan
nanoparticles and were characterized for particle size, morphology, zeta
potential, AOase loading efficiency and in vitro transformation assay. The
chitosan nanoparticles were spherical in shape with the average diameter
of 100nm which increased to 294nm upon successful loading of AOase. Under
optimized conditions, the loading capacity of the chitosan nanoparticle
was determined to be 71% for AOase. Further, immobilization also increased
the stability of AOase at varying temperature (4-37&deg;C) and pH (5-10)
for a period of 30days with the increased enzymatic activity
(159.57Uml-1). It also facilitated increased biotransformation (89%) of
As(III) to As(V). A conceptual understanding of biological responses to
AOase loaded chitosan nanoparticles is needed for the development of novel
methods of drug delivery.
KW - Arsenic
KW - Arsenite oxidase
KW - Biotransformation
KW - Chitosan
KW - Nanoparticles
LA - eng
IS - 1879-0003 (Electronic)
PT - Journal Article
TA - Int J Biol Macromol
YR - 2018
DATE- 20171128
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - International journal of biological macromolecules
EDAT- 20170811
STAT- In-Process
DOCNO- medline/28803973

88 - TOXLINE
TI - Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite
Exposure on Human Hepatic HepaRG Cells.
AU - Dreval K
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, Jefferson, Arkansas 72079.
AU - Tryndyak V
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, Jefferson, Arkansas 72079.
AU - Kindrat I
AD - Department of Biological and Medical Chemistry, Ivano-Frankivsk National
Medical University, Ivano-Frankivsk, Ukraine.
AU - Twaddle NC
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, Jefferson, Arkansas 72079.
AU - Orisakwe OE
AD - Department of Experimental Pharmacology and Toxicology, University of Port-
Harcourt, Rivers State, Nigeria.
AU - Mudalige TK
AD - Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and
Drug Administration, Jefferson, Arkansas 72079.
AU - Beland FA
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, Jefferson, Arkansas 72079.
AU - Doerge DR
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, Jefferson, Arkansas 72079.
AU - Pogribny IP
AD - Division of Biochemical Toxicology, National Center for Toxicological
Research, Jefferson, Arkansas 72079.
SO - Toxicol Sci. 2018, Apr 01; 162(2):676-687. [Toxicological sciences : an
official journal of the Society of Toxicology]
AB - Inorganic arsenic is a human carcinogen associated with several types of
cancers, including liver cancer. Inorganic arsenic has been postulated to
target stem cells, causing their oncogenic transformation. This is
proposed to be one of the key events in arsenic-associated carcinogenesis;
however, the underlying mechanisms for this process remain largely
unknown. To address this question, human hepatic HepaRG cells, at
progenitor and differentiated states, were continuously treated with a
noncytotoxic concentration of 1 &mu;M sodium arsenite (NaAsO2). The HepaRG
cells demonstrated active intracellular arsenite metabolism that shared
important characteristic with primary human hepatocytes. Treatment of
proliferating progenitor-like HepaRG cells with NaAsO2 inhibited their
differentiation into mature hepatocyte-like cells, up-regulated genes
involved in cell growth, proliferation, and survival, and down-regulated
genes involved in cell death. In contrast, treatment of differentiated
hepatocyte-like HepaRG cells with NaAsO2 resulted in enhanced cell death
of mature hepatocyte-like cells, overexpression of cell death-related
genes, and down-regulation of genes in the cell proliferation pathway,
while biliary-like cells remained largely unaffected. Mechanistically, the
cytotoxic effect of arsenic on mature hepatocyte-like HepaRG cells may be
attributed to arsenic-induced dysregulation of cellular iron metabolism.
The inhibitory effect of NaAsO2 on the differentiation of progenitor
cells, the resistance of biliary-like cells to cell death, and the
enhanced cell death of functional hepatocyte-like cells resulted in
stem-cell activation. These effects favored the proliferation of liver
progenitor cells that can serve as a source of initiation and driving
force of arsenic-mediated liver carcinogenesis.
LA - eng
IS - 1096-0929 (Electronic)
PT - Journal Article
TA - Toxicol Sci
YR - 2018
DATE- 20180412
CITO- NLM
CS - United States
FJT - Toxicological sciences : an official journal of the Society of Toxicology
STAT- In-Data-Review
CM - Cites: Int J Cancer. 2015 Mar 1;136(5):E359-86 (medline /25220842)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):1944-53 (medline
/23800676)
CM - Cites: Food Chem Toxicol. 2018 Jan;111:482-493 (medline /29217265)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 2004;84:1-477 (medline
/15645577)
CM - Cites: Biochim Biophys Acta. 2015 May;1853(5):1130-44 (medline /25661197)
CM - Cites: J Natl Cancer Inst. 2010 May 5;102(9):638-49 (medline /20339138)
CM - Cites: Chem Res Toxicol. 2013 Jan 18;26(1):96-105 (medline /23137061)
CM - Cites: Inorg Chem. 2005 Apr 18;44(8):2964-72 (medline /15819584)
CM - Cites: Environ Health Perspect. 2011 Jan;119(1):11-9 (medline /20682481)
CM - Cites: Crit Rev Toxicol. 2010 Nov;40(10):912-27 (medline /20812815)
CM -Cites: Toxicol Sci. 2011 Jan;119(1):73-83 (medline /20937726)
CM -Cites: Toxicol Sci. 2011 Mar;120 Suppl 1:S192-203 (medline /21071725)
CM -Cites: Arch Toxicol. 2014 Aug;88(8):1619-29 (medline /25005685)
CM -Cites: Nat Protoc. 2008;3(6):1101-8 (medline /18546601)
CM -Cites: Gastroenterology. 2004 Apr;126(4):1147-56 (medline /15057753)
CM -Cites: Exp Cell Res. 2013 Apr 1;319(6):875-87 (medline /23219847)
CM -Cites: Nat Rev Cancer. 2015 Nov;15(11):653-67 (medline /26493646)
CM -Cites: Acta Pharm Sin B. 2016 Sep;6(5):426-429 (medline /27709011)
CM -Cites: Exp Cell Res. 2013 Jan 15;319(2):126-32 (medline /22999864)
CM -Cites: IARC Monogr Eval Carcinog Risk Chem Hum. 1980;23:1-415 (medline
/6933135)
CM - Cites: Toxicol Appl Pharmacol. 2010 May 15;245(1):47-56 (medline
/20138079)
CM - Cites: Exp Biol Med (Maywood). 2016 Sep;241(15):1653-62 (medline
/27390263)
CM - Cites: Methods Mol Biol. 2009;563:379-98 (medline /19597796)
CM - Cites: Sci Rep. 2015 Oct 08;5:14993 (medline /26447599)
CM - Cites: Hepatology. 2011 Dec;54(6):2159-72 (medline /21809358)
CM - Cites: Chem Res Toxicol. 2006 Aug;19(8):1010-8 (medline /16918239)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):366-76 (medline
/15276416)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):1982-7 (medline
/18708388)
CM - Cites: Crit Rev Clin Lab Sci. 2007;44(5-6):413-59 (medline /17943492)
CM - Cites: Nature. 2017 Jul 20;547(7663):350-354 (medline /28700576)
CM - Cites: Toxicol Appl Pharmacol. 2011 Feb 15;251(1):59-69 (medline
/21134390)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt C):11-465 (medline
/23189751)
CM - Cites: Chem Res Toxicol. 2014 Nov 17;27(11):1979-89 (medline /25325836)
CM - Cites: Antioxid Redox Signal. 2002 Oct;4(5):749-58 (medline /12470502)
CM - Cites: Environ Health Perspect. 2013 Mar;121(3):295-302 (medline
/23458756)
CM - Cites: J Cell Biochem. 2013 Jul;114(7):1575-83 (medline /23334867)
CM - Cites: Environ Res. 2014 Nov;135:120-5 (medline /25262084)
CM - Cites: Toxicol Sci. 2011 Oct;123(2):305-32 (medline /21750349)
CM - Cites: Biofabrication. 2017 Jun 30;9(3):035001 (medline /28664876)
CM - Cites: Hepatology. 2007 Apr;45(4):957-67 (medline /17393521)
DOCNO- medline/29301061

89 - TOXLINE
TI - Arsenic speciation in food in Belgium. Part 2: Cereals and cereal
products.
AU - Ruttens A
AD - CODA-CERVA-VAR Veterinary and Agrochemical Research Centre, Leuvensesteenweg
17, B-3080 Tervuren, Belgium. Electronic address: ann.ruttens@coda-cerva.be.
AU - Cheyns K
AD - CODA-CERVA-VAR Veterinary and Agrochemical Research Centre, Leuvensesteenweg
17, B-3080 Tervuren, Belgium.
AU - Blanpain AC
AD - CODA-CERVA-VAR Veterinary and Agrochemical Research Centre, Leuvensesteenweg
17, B-3080 Tervuren, Belgium.
AU - De Temmerman L
AD - CODA-CERVA-VAR Veterinary and Agrochemical Research Centre, Leuvensesteenweg
17, B-3080 Tervuren, Belgium.
AU - Waegeneers N
AD - CODA-CERVA-VAR Veterinary and Agrochemical Research Centre, Leuvensesteenweg
17, B-3080 Tervuren, Belgium.
SO - Food Chem Toxicol. 2018, Apr 22; 118:32-41. [Food and chemical toxicology
: an international journal published for the British Industrial Biological
Research Association]
AB - This study reports results of total arsenic (Astot) and various As species
in 75 samples of cereals and cereal products bought on the Belgian market.
In addition to rice, the samples were wheat, pasta, bread and some
breakfast cereals. The inorganic species arsenite (AsIII) and arsenate
(AsV), and the organic As compounds dimethyl arsinate (DMA) and monomethyl
arsonate (MA) were the only As species detected. Mean Astot was
0.150&#8239;&plusmn;&#8239;0.089&#8239;mg&#8239;kg-1 in rice and
0.012&#8239;&plusmn;&#8239;0.008&#8239;mg kg- in the non-rice cereals. The
inorganic arsenic fraction (Asi&#8239;=&#8239;AsIII + AsV)
dominated in all samples and was in the range 55%-100%. Significantly
higher Astot and Asi concentrations were observed in white rice and brown
rice compared to Basmati rice. Within the group of non-rice cereals bread
and pasta showed significantly lower concentrations compared to wheat. All
30 rice samples were conform to the European maximum limits for Asi, laid
down in Commission Regulation (EU) 2015/1006. Although regulatory limits
certainly can help to protect consumer health, our results suggest that
the currently fixed European maximum levels are, in Belgium, not expected
to have any impact on the human exposure to Asi, which is a known
carcinogenic substance.
KW - Dietary exposure
KW - European maximum limit
KW - Inorganic arsenic
KW - Rice
KW - Rice products
KW - Wheat
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180422
STAT- Publisher
DOCNO- medline/29689359

90 - TOXLINE
TI - Role of arsenic exposure in adipose tissue dysfunction and its possible
implication in diabetes pathophysiology.
AU - Renu K
AD - Department of Biomedical Sciences, School of Biosciences and Technology, VIT
University, Vellore, Tamil Nadu- 632014, India.
AU - Madhyastha H
AD - Department of Applied Physiology, Faculty of Medicine, University of
Miyazaki, Miyazaki 889 1692, Japan.
AU - Madhyastha R
AD - Department of Applied Physiology, Faculty of Medicine, University of
Miyazaki, Miyazaki 889 1692, Japan.
AU - Maruyama M
AD - Department of Applied Physiology, Faculty of Medicine, University of
Miyazaki, Miyazaki 889 1692, Japan.
AU - Arunachlam S
AD - Department of Biotechnology, Kalasalingam University, Krishnankoil-626126,
Tamil Nadu, India.
AU - V G A
AD - Department of Biomedical Sciences, School of Biosciences and Technology, VIT
University, Vellore, Tamil Nadu- 632014, India. Electronic address:
abilash.vg@vit.ac.in.
SO - Toxicol Lett. 2018, Mar 01; 284:86-95. [Toxicology letters]
AB - Exposure to arsenic in drinking water can stimulate a diverse number of
diseases that originate from impaired lipid metabolism in adipose and
glucose metabolism, leading to insulin resistance. Arsenic inhibits
differentiation of adipocyte and mediates insulin resistance with
diminutive information on arsenicosis on lipid storage and lipolysis. This
review focused on different mechanisms and pathways involved in
adipogenesis and lipolysis in adipose tissue during arsenic-induced
diabetes. Though arsenic is known to cause type2 diabetes through
different mechanisms, the role of adipose tissue in causing type2 diabetes
is still unclear. With the existing literature, this review exhibits the
effect of arsenic on adipose tissue and its signalling events such as
SIRT3- FOXO3a signalling pathway, Ras -MAP -AP-1 cascade, PI(3)-K-Akt
pathway, endoplasmic reticulum stress protein, C/EBP homologous protein
(CHOP10) and GPCR pathway with role of adipokines. There is a need to
elucidate the different types of adipokines which are involved in
arsenic-induced diabetes. The exhibited information brings to light that
arsenic has negative effects on a white adipose tissue (WAT) by decreasing
adipogenesis and enhancing lipolysis. Some of the epidemiological studies
show that arsenic would causes obesity. Few studies indicate that arsenic
might induces lipodystrophy condition. Further research is needed to
evaluate the mechanistic link between arsenic and adipose tissue
dysfunction which leads to insulin resistance.
KW - Adipogenesis
KW - Adipose tissue pathophysiology
KW - Arsenic
KW - Diabetes
KW - Lipolysis
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
PT - Review
TA - Toxicol Lett
YR - 2018
DATE- 20180207
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Toxicology letters
EDAT- 20171201
STAT- In-Process
DOCNO- medline/29198881

91 - TOXLINE
TI - Associations between urinary total arsenic levels, fetal development, and
neonatal birth outcomes: A cohort study in Taiwan.
AU - Liao KW
AD - Institute of Environmental and Occupational Health Sciences, School of
Medicine, National Yang Ming University, Taipei, Taiwan.
AU - Chang CH
AD - Institute of Environmental and Occupational Health Sciences, School of
Medicine, National Yang Ming University, Taipei, Taiwan.
AU - Tsai MS
AD - Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei,
Taiwan; School of Medicine, Fu Jen Catholic University, Taipei, Taiwan; School of
Medicine, Taipei Medical University, Taipei, Taiwan.
AU - Chien LC
AD - School of Public Health, Taipei Medical University, Taipei, Taiwan.
AU - Chung MY
AD - Department of Life Sciences, Institute of Genome Sciences, National Yang Ming
University, Taipei, Taiwan.
AU - Mao IF
AD - Department of Occupational Safety and Health, Chung Shan Medical University,
Taichung, Taiwan.
AU - Tsai YA
AD - Institute of Environmental and Occupational Health Sciences, School of
Medicine, National Yang Ming University, Taipei, Taiwan.
AU - Chen ML
AD - Institute of Environmental and Occupational Health Sciences, School of
Medicine, National Yang Ming University, Taipei, Taiwan. Electronic address:
mlchen@ym.edu.tw.
SO - Sci Total Environ. 2018, Jan 15; 612:1373-1379. [The Science of the total
environment]
AB - BACKGROUND: Arsenic exposure is a global health concern. Several studies
have focused on chronic arsenic exposure in adults; however, limited data
are available regarding the potential adverse effects of prenatal exposure
on fetuses and neonates.
AB - OBJECTIVES: To assess which time point maternal arsenic exposure may
influence the fetus during pregnancy and birth outcomes.
AB - METHODS: In this study, total arsenic concentrations were analyzed in
urine samples collected from 130 women with singleton pregnancies
(22-45years old) in Taiwan from March to December of 2010. All fetal
biometric measurements in each trimester period and birth outcomes at
delivery were obtained. We applied a generalized estimating equation model
and multivariate regression models to evaluate the associations between
maternal urinary total arsenic (UtAs) exposure during pregnancy, fetal
biometric measurements, and neonatal birth outcomes.
AB - RESULTS: We observed statistically significant correlations between
maternal UtAs levels and the fetal biparietal diameter over all three
trimesters (&beta;=-1.046mm, p < 0.05). Multiple regression analyses
showed a negative association between maternal UtAs levels and chest
circumference in the first trimester (&beta;=-0.721cm, p < 0.05), and
second-trimester UtAs exposure was associated with decreases in birth
weight (&beta;=-173.26g, p < 0.01), head circumference (&beta;=-0.611cm,
p < 0.05), and chest circumference (&beta;=-0.654cm, p < 0.05).
Dose-response relationships were also observed for maternal UtAs exposure
and birth outcomes.
AB - CONCLUSIONS: We identified a negative relationship between maternal UtAs
levels during pregnancy, fetal development, and neonatal birth outcomes.
These findings should be confirmed in future studies with large sample
sizes.
KW - Birth outcomes
KW - Cohort study
KW - Fetal development
KW - Maternal exposure
KW - Urinary total arsenic
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180103
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20170925
STAT- In-Process
DOCNO- medline/28898944

92 - TOXLINE
TI - Associations of arsenic exposure with telomere length and na�ve T
cells in childhood- A birth cohort study.
AU - Mannan T
AD - Department of Immunology, Bangladesh University of Health Sciences, Dhaka-
1216, Bangladesh.
AU - Ahmed S
AD - Infectious Diseases Division, icddr,b, Dhaka-1212, Bangladesh.
AU - Akhtar E
AD - Infectious Diseases Division, icddr,b, Dhaka-1212, Bangladesh.
AU - Ahsan KB
AD - Infectious Diseases Division, icddr,b, Dhaka-1212, Bangladesh.
AU - Haq A
AD - Infectious Diseases Division, icddr,b, Dhaka-1212, Bangladesh.
AU - Kippler M
AD - Institute of Environmental Medicine, Karolinska Institutet, SE- 171 77
Stockholm, Sweden.
AU - Vahter M
AD - Institute of Environmental Medicine, Karolinska Institutet, SE- 171 77
Stockholm, Sweden.
AU - Raqib R
AD - Infectious Diseases Division, icddr,b, Dhaka-1212, Bangladesh.
SO - Toxicol Sci. 2018, May 10. [Toxicological sciences : an official journal
of the Society of Toxicology]
AB - There is limited knowledge of association between arsenic exposure and
telomere length (TL) and signal joint T-cell receptor excision circle
(sjTREC) that are potential biomarkers of immune senescence and disease
susceptibility. We aimed to clarify whether long-term inorganic arsenic
exposure influences TL and sjTRECs in childhood. Children born in a
longitudinal mother-child cohort were followed-up at 4.5 (n=275) and 9
years (n=351) of age. Arsenic exposure was assessed by metabolite
concentrations in urine (U-As) from mothers at gestational week 8
(prenatal) and their children at 4.5 and 9 years. TL and sjTRECs were
determined in blood cells using quantitative PCR. The oxidative DNA damage
marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in plasma was measured by
ELISA. In multivariable-adjusted spline regression analyses, both prenatal
and childhood arsenic exposure above U-As of 45&micro;g/L were
significantly inversely associated with TL and sjTRECs at 9years. Fraction
of monomethylarsonic acid (MMA) above spline knot 7% were significantly
inversely associated with both TL and sjTRECs reflecting increased
toxicity due to less-efficient arsenic metabolism in 9 years old children.
Prenatal and childhood arsenic exposure were positively associated with
8-OHdG at 9 years which in turn was inversely associated with sjTRECs at 9
years. However, adjustment with 8-OHdG did not change the estimates of the
association of U-As with sjTRECs reflecting little contribution from
8-OHdG-induced oxidative stress. Our findings suggest that chronic arsenic
exposure from early life can result in TL attrition and lower production
of na�ve T cells potentially leading to immunosenescence and
immunodeficiency.
LA - eng
IS - 1096-0929 (Electronic)
PT - Journal Article
TA - Toxicol Sci
YR - 2018
DATE- 20180514
CITO- NLM
CS - United States
FJT - Toxicological sciences : an official journal of the Society of Toxicology
EDAT- 20180510
STAT- Publisher
DOCNO- medline/29757418

93 - TOXLINE
TI - Estimating the risk of bladder and kidney cancer from exposure to
low-levels of arsenic in drinking water, Nova Scotia, Canada.
AU - Saint-Jacques N
AD - Nova Scotia Cancer Care Program, Nova Scotia Health Authority, 1276 South
Park Street, Room 560 Bethune Building, Halifax B3H 2Y9, Nova Scotia, Canada.
Electronic address: nathalie.st-jacques@nshealth.ca.
AU - Brown P
AD - Centre for Global Health Research, St. Michael's Hospital, 30 Bond Street,
Toronto M5B 1W8, Ontario, Canada. Electronic address: patrick.brown@utoronto.ca.
AU - Nauta L
AD - Population Cancer Research Program, Dalhousie University, 1494 Carlton
Street, PO Box 15000, Halifax B3H 4R2, Nova Scotia, Canada. Electronic address:
lnauta@dal.ca.
AU - Boxall J
AD - GIS Centre Killam Library, Dalhousie University, 6225 University Avenue,
Halifax B3H 4R2, Nova Scotia, Canada. Electronic address: james.boxall@dal.ca.
AU - Parker L
AD - Department of Pediatrics and Population Cancer Research Program, Dalhousie
University, 1494 Carlton Street, PO Box 15000, Halifax B3H 4R2, Nova Scotia,
Canada. Electronic address: louise.parker@dal.ca.
AU - Dummer TJB
AD - The University of British Columbia, Centre for Excellence in Cancer
Prevention, School of Population and Public Health, 2206 East Mall, Vancouver V6T
1Z3, British Columbia, Canada. Electronic address: trevor.dummer@ubc.ca.
SO - Environ Int. 2018, 01; 110:95-104. [Environment international]
AB - Arsenic in drinking water impacts health. Highest levels of arsenic have
been historically observed in Taiwan and Bangladesh but the contaminant
has been affecting the health of people globally. Strong associations have
been confirmed between exposure to high-levels of arsenic in drinking
water and a wide range of diseases, including cancer. However, at lower
levels of exposure, especially near the current World Health Organization
regulatory limit (10&mu;g/L), this association is inconsistent as the
effects are mostly extrapolated from high exposure studies. This
ecological study used Bayesian inference to model the relative risk of
bladder and kidney cancer at these lower concentrations-0-2&mu;g/L;
2-5&mu;g/L and; &ge;5&mu;g/L of arsenic-in 864 bladder and 525 kidney
cancers diagnosed in the study area, Nova Scotia, Canada between 1998 and
2010. The model included proxy measures of lifestyle (e.g. smoking) and
accounted for spatial dependencies. Overall, bladder cancer risk was 16%
(2-5&mu;g/L) and 18% (&ge;5&mu;g/L) greater than that of the referent
group ( < 2&mu;g/L), with posterior probabilities of 88% and 93% for
these risks being above 1. Effect sizes for kidney cancer were 5%
(2-5&mu;g/L) and 14% (&ge;5&mu;g/L) above that of the referent group
( < 2&mu;g/L), with probabilities of 61% and 84%. High-risk areas were
common in southwestern areas, where higher arsenic-levels are associated
with the local geology. The study suggests an increased bladder cancer,
and potentially kidney cancer, risk from exposure to drinking water
arsenic-levels within the current the World Health Organization maximum
acceptable concentration.
KW - *Arsenic
KW - *BYM model
KW - *Bladder and kidney cancer
KW - *Drinking water
KW - *Geostatistical analysis
KW - *Small-area disease mapping
RN - N712M78A8G
LA - eng
IS - 1873-6750 (Electronic)
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
TA - Environ Int
YR - 2018
DATE- 20180420
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Environment international
EDAT- 20171031
STAT- MEDLINE
DOCNO- medline/29089168

94 - TOXLINE
TI - NF-&kappa;B-regulated miR-155, via repression of QKI, contributes to the
acquisition of CSC-like phenotype during the neoplastic transformation of
hepatic cells induced by arsenite.
AU - Chen C
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
AU - Luo F
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
AU - Yang Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
AU - Wang D
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, Guizhou, People's Republic of China.
AU - Yang P
AD - The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou
Medical University, Guangzhou, Guangdong, People's Republic China.
AU - Xue J
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
AU - Dai X
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
AU - Liu X
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
AU - Xu H
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
AU - Lu J
AD - The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou
Medical University, Guangzhou, Guangdong, People's Republic China.
AU - Zhang A
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, Guizhou, People's Republic of China.
AU - Liu Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu, People's Republic of
China.
SO - Mol Carcinog. 2018, Apr; 57(4):483-493. [Molecular carcinogenesis]
AB - Chronic exposure to arsenite can cause various human tumors. For the
initiation and recurrence of human liver cancer, the acquisition of
CSC-like properties is essential. In various cancers, microRNAs (miRNAs)
act as regulators in induction of CSC-like properties. Liver cancers
over-express miR-155, but the mechanism relating miR-155 and
arsenite-induced liver cancer is unknown. Here, we show that long-term
exposure of L-02 cells to arsenite increases miR-155 levels by activation
of NF-&kappa;B and leads to the acquisition of CSC-like properties. In
spheroids formed from arsenite-transformed L-02 cells, the levels of
miR-155 positively relate to the levels of CD90, EpCAM, and OCT4.
Inhibition of miR-155, by reduction of SOX2 and OCT4, results in
suppression of spheroid formation. Luciferase reporter assays indicate
that QKI is a target of miR-155. Inhibition of QKI expression by miR-155
promotes arsenite-induced acquisition of CSC-like properties, whereas QKI
over-expression has the opposite effect. Collectively, the findings
demonstrate that miR-155, driven by NF-&kappa;B, reduces QKI expression
and is involved in acquisition of the CSC-like phenotype during neoplastic
transformation of hepatic cells induced by arsenite.
KW - NF-κB
KW - QKI
KW - arsenite
KW - cancer stem cells (CSCs)
KW - miR-155
LA - eng
IS - 1098-2744 (Electronic)
PT - Journal Article
TA - Mol Carcinog
YR - 2018
DATE- 20180301
CI - &copy; 2017 Wiley Periodicals, Inc.
CITO- NLM
CS - United States
FJT - Molecular carcinogenesis
EDAT- 20171229
STAT- In-Data-Review
DOCNO- medline/29240254

95 - TOXLINE
TI - PI3K/Akt/GSK3&beta; induced CREB activation ameliorates arsenic mediated
alterations in NMDA receptors and associated signaling in rat hippocampus:
Neuroprotective role of curcumin.
AU - Srivastava P
AD - Developmental Toxicology and NeuroToxicology Laboratory, Systems Toxicology
and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research
(CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, UP,
India; School of Pharmacy, Babu Banarsi Das University, Faizabad Road, Lucknow, 226
028, UP, India.
AU - Dhuriya YK
AD - Developmental Toxicology and NeuroToxicology Laboratory, Systems Toxicology
and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research
(CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, UP,
India.
AU - Kumar V
AD - Human Genome and Stem-Cell Research Center, Institute of Biosciences,
University of S�o Paulo, Brazil.
AU - Srivastava A
AD - Developmental Toxicology and NeuroToxicology Laboratory, Systems Toxicology
and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research
(CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, UP,
India.
AU - Gupta R
AD - Developmental Toxicology and NeuroToxicology Laboratory, Systems Toxicology
and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research
(CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, UP,
India; School of Pharmacy, Babu Banarsi Das University, Faizabad Road, Lucknow, 226
028, UP, India.
AU - Shukla RK
AD - Developmental Toxicology and NeuroToxicology Laboratory, Systems Toxicology
and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research
(CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, UP,
India.
AU - Yadav RS
AD - Department of Criminology and Forensic Science, Dr. Harisingh Gour Central
University, Sagar, 470003, MP, India.
AU - Dwivedi HN
AD - School of Pharmacy, Babu Banarsi Das University, Faizabad Road, Lucknow, 226
028, UP, India.
AU - Pant AB
AD - Developmental Toxicology and NeuroToxicology Laboratory, Systems Toxicology
and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research
(CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, UP,
India. Electronic address: abpant@iitr.res.in.
AU - Khanna VK
AD - Developmental Toxicology and NeuroToxicology Laboratory, Systems Toxicology
and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research
(CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, UP,
India. Electronic address: vkkhanna1@iitr.res.in.
SO - Neurotoxicology. 2018, Apr 30; 67:190-205. [Neurotoxicology]
AB - Protective efficacy of curcumin in arsenic induced NMDA receptor
dysfunctions and PI3K/Akt/ GSK3&beta; signalling in hippocampus has been
investigated in vivo and in vitro. Exposure to sodium arsenite (in vivo -
20&#8239;mg/kg, body weight p.o. for 28 days; in vitro - 10&#8239;&mu;M
for 24&#8239;h) and curcumin (in vivo - 100&#8239;mg/kg body weight p.o.
for 28 days; in vitro - 20&#8239;&mu;M for 24&#8239;h) was carried out
alone or simultaneously. Treatment with curcumin ameliorated sodium
arsenite induced alterations in the levels of NMDA receptors, its receptor
subunits and synaptic proteins - pCaMKII&alpha;, PSD-95 and SynGAP both in
vivo and in vitro. Decreased levels of BDNF, pAkt, pERK1/2, pGSK3&beta;
and pCREB on sodium arsenite exposure were also protected by curcumin.
Curcumin was found to decrease sodium arsenite induced changes in
hippocampus by modulating PI3K/Akt/GSK3&beta; neuronal survival pathway,
known to regulate various cellular events. Treatment of hippocampal
cultures with pharmacological inhibitors for ERK1/2, GSK3&beta; and Akt
individually inhibited levels of CREB and proteins associated with
PI3K/Akt/GSK3&beta; pathway. Simultaneous treatment with curcumin was
found to improve sodium arsenite induced learning and memory deficits in
rats assessed by water maze and Y-maze. The results provide evidence that
curcumin exercises its neuroprotective effect involving PI3K/Akt pathway
which may affect NMDA receptors and downstream signalling through
TrK&beta; and BDNF in arsenic induced cognitive deficits in hippocampus.
KW - Curcumin
KW - Hippocampus
KW - Learning and memory
KW - NMDA receptors
KW - PI3K/Akt/GSK3β signalling
KW - Sodium arsenite
LA - eng
IS - 1872-9711 (Electronic)
PT - Journal Article
TA - Neurotoxicology
YR - 2018
DATE- 20180616
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Neurotoxicology
EDAT- 20180430
STAT- Publisher
DOCNO- medline/29723552

96 - TOXLINE
TI - Rethinking anaerobic As(III) oxidation in filters: Effect of indigenous
nitrate respirers.
AU - Cui J
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing,
100085, PR China.
AU - Du J
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing,
100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049,
China.
AU - Tian H
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing,
100085, PR China.
AU - Chan T
AD - National Synchrotron Radiation Research Center, HsinChu, 300, Taiwan, ROC.
Electronic address: chan.ts@nsrrc.org.tw.
AU - Jing C
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing,
100085, PR China; University of Chinese Academy of Sciences, Beijing, 100049,
China. Electronic address: cyjing@rcees.ac.cn.
SO - Chemosphere. 2018, Apr; 196:223-230. [Chemosphere]
AB - Microorganisms play a key role in the redox transformation of arsenic (As)
in aquifers. In this study, the impact of indigenous bacteria, especially
the prevailing nitrate respirers, on arsenite (As(III)) oxidation was
explored during groundwater filtration using granular TiO2 and subsequent
spent TiO2 anaerobic landfill. X-ray absorption near edge structure
spectroscopy analysis showed As(III) oxidation (46% in 10 days) in the
presence of nitrate in the simulated anaerobic landfills. Meanwhile, iron
(Fe) species on the spent TiO2 were dominated by amorphous ferric
arsenate, ferrihydrite and goethite. The Fe phase showed no change during
the anaerobic landfill incubation. Batch incubation experiments implied
that the indigenous bacteria completely oxidized As(III) to arsenate
(As(V)) in 10 days using nitrate as the terminal electron acceptor under
anaerobic conditions. The bacterial community analysis indicated that
various kinds of microbial species exist in groundwater matrix.
Phylogenetic tree analysis revealed that Proteobacteria was the dominant
phylum, with Hydrogenophaga (34%), Limnohabitans (16%), and Simplicispira
(7%) as the major bacterial genera. The nitrate respirers especially from
the Hydrogenophaga genus anaerobically oxidized As(III) using nitrate as
an electron acceptor instead of oxygen. Our study implied that microbes
can facilitate the groundwater As oxidation using nitrate on the
adsorptive media.
KW - Anaerobic As(III) oxidation
KW - Bacterial diversity
KW - Groundwater filtration
KW - Landfill incubation
KW - Nitrate respirers
RN - 1310-14-1
RN - 87PZU03K0K
RN - E1UOL152H7
RN - N5509X556J
RN - N712M78A8G
RN - N7CIZ75ZPN
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180517
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171227
STAT- MEDLINE
DOCNO- medline/29304460

97 - TOXLINE
TI - Organic Arsenicals as Functional Motifs in Polymer and Biomaterials
Science.
AU - Tanaka J
AD - Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
AU - Davis TP
AD - ARC Centre of Excellence in Convergent Bio-Nano Science and Technology,
Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus),
399 Royal Parade, Parkville, Victoria, 3152, Australia.
AU - Wilson P
AD - ARC Centre of Excellence in Convergent Bio-Nano Science and Technology,
Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus),
399 Royal Parade, Parkville, Victoria, 3152, Australia.
SO - Macromol Rapid Commun. 2018, May 28:e1800205. [Macromolecular rapid
communications]
AB - Arsenic (As) exhibits diverse (bio)chemical reactivity and biological
activity depending upon its oxidation state. However, this distinctive
reactivity has been largely overlooked across many fields owing to
concerns regarding the toxicity of arsenic. Recently, a clinical
renaissance in the use of arsenicals, including organic arsenicals that
are known to be less toxic than inorganic arsenicals, alludes to the
possibility of broader acceptance and application in the field of polymer
and biomaterials science. Here, current examples of
polymeric/macromolecular arsenicals are reported to stimulate interest and
highlight their potential as a novel platform for functional, responsive,
and bioactive materials.
KW - biomaterials
KW - drug delivery systems
KW - imaging
KW - nanoparticles
KW - polymerization
LA - eng
IS - 1521-3927 (Electronic)
PT - Journal Article
PT - Review
TA - Macromol Rapid Commun
YR - 2018
DATE- 20180528
CI - &copy; 2018 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.
CITO- NLM
CS - Germany
FJT - Macromolecular rapid communications
EDAT- 20180528
STAT- Publisher
DOCNO- medline/29806240

98 - TOXLINE
TI - Carcinogenic and non-carcinogenic risk assessments of arsenic
contamination in drinking water of Ardabil city in the Northwest of Iran.
AU - Sadeghi F
AD - a Center for Water Quality Research (CWQR) , Institute for Environmental
Research (IER), Tehran University of Medical Sciences , Tehran , Iran.
AU - Nasseri S
AD - b Department of Environmental Health Engineering , School of Public Health,
Tehran University of Medical Sciences , Tehran , Iran.
AU - Yunesian M
AD - c Center for Air Pollution Research (CAPR) , Institute for Environmental
Research (IER), Tehran University of Medical Sciences , Tehran , Iran.
AU - Nabizadeh R
AD - c Center for Air Pollution Research (CAPR) , Institute for Environmental
Research (IER), Tehran University of Medical Sciences , Tehran , Iran.
AU - Mosaferi M
AD - d Tabriz Health Services Management Research Center , Tabriz University of
Medical Sciences , Tabriz , Iran.
AU - Mesdaghinia A
AD - b Department of Environmental Health Engineering , School of Public Health,
Tehran University of Medical Sciences , Tehran , Iran.
SO - J Environ Sci Health A Tox Hazard Subst Environ Eng. 2018, Apr 16;
53(5):421-429. [Journal of environmental science and health. Part A,
Toxic/hazardous substances & environmental engineering]
AB - Based on the environmental health assessment framework of the United State
Environmental Protection Agency, a quantitative health risk assessment of
arsenic in contaminated drinking water in a city in the northwest of Iran
has been carried out. In the exposure assessment step, arsenic
concentrations in drinking water were determined during four seasons. In
addition, the water ingestion rate for different age groups in this region
was determined. The concentration of arsenic in 163 collected samples from
different locations during four seasons ranged from 0 to 99 &mu;g
L-1. Furthermore, a high percentage of the samples manifested higher
levels than the permissible limit of 10 &mu;g L-1. The total daily
water intake rates of four age groups 1 to < 2 (group 1), 2 to < 6
(group 2), 6 to < 16 (group 3), and &ge;16 years (group 4) were
estimated as 0.86, 1.49, 2.00, and 2.33 L day-1, respectively.
Calculating the lifetime average daily dose of arsenic indicated that
adults (group 4) had the highest and children (group 1) had the lowest
daily intake of arsenic in their entire life. The results of risk
characteristic showed that the order of excess lifetime cancer risk via
arsenic exposure in the four groups was 4 > 3 > 2 > 1. The
estimated risks for all age groups were higher than the acceptable range
(1E-6 to 1E-4). The hazard quotient values for all of the classified
groups were lower than the recommended limit values ( < 1), but it cannot
be concluded that potential non-carcinogenicity risks are non-existent
since the possible exposure to arsenic via food and skin may also pose the
risk.
KW - Arsenic
KW - carcinogenic risk assessment
KW - drinking water
KW - non-carcinogenic risk assessment
RN - N712M78A8G
LA - eng
IS - 1532-4117 (Electronic)
PT - Journal Article
TA - J Environ Sci Health A Tox Hazard Subst Environ Eng
YR - 2018
DATE- 20180525
CITO- NLM
CS - England
CSET- IM
FJT - Journal of environmental science and health. Part A, Toxic/hazardous
substances &amp; environmental engineering
EDAT- 20171226
STAT- MEDLINE
DOCNO- medline/29278989

99 - TOXLINE
TI - Arsenic accumulation in rice (Oryza sativa L.) is influenced by
environment and genetic factors.
AU - Kumarathilaka P
AD - School of Civil Engineering and Surveying, Faculty of Health, Engineering and
Sciences, University of Southern Queensland, West Street, Toowoomba, Queensland
4350, Australia.
AU - Seneweera S
AD - Center for Crop Health, Faculty of Health, Engineering and Sciences,
University of Southern Queensland, West Street, Toowoomba, Queensland 4350,
Australia.
AU - Meharg A
AD - Queen's University Belfast, Institute for Global Food Security, David Keir
Building, Malone Road, Belfast BT9 5BN, United Kingdom.
AU - Bundschuh J
AD - School of Civil Engineering and Surveying, Faculty of Health, Engineering and
Sciences, University of Southern Queensland, West Street, Toowoomba, Queensland
4350, Australia; UNESCO Chair on Groundwater Arsenic within the 2030 Agenda for
Sustainable Development University of Southern Queensland, West Street, Toowoomba,
Queensland 4350, Australia. Electronic address: jochen.bundschuh@usq.edu.au.
SO - Sci Total Environ. 2018, Jun 13; 642:485-496. [The Science of the total
environment]
AB - Arsenic (As) elevation in paddy soils will have a negative impact on both
the yield and grain quality of rice (Oryza sativa L.). The mechanistic
understanding of As uptake, translocation, and grain filling is an
important aspect to produce rice grains with low As concentrations through
agronomical, physico-chemical, and breeding approaches. A range of factors
(i.e. physico-chemical, biological, and environmental) govern the
speciation and mobility of As in paddy soil-water systems. Major As uptake
transporters in rice roots, such as phosphate and aquaglyceroporins,
assimilate both inorganic (As(III) and As(V)) and organic As (DMA(V) and
MMA(V)) species from the rice rhizosphere. A number of metabolic pathways
(i.e. As (V) reduction, As(III) efflux, and As(III)-thiol complexation and
subsequent sequestration) are likely to play a key role in determining the
translocation and substantial accumulation of As species in rice tissues.
The order of translocation efficiency (caryopsis-to-root) for different As
species in rice plants is comprehensively evaluated as follows:
DMA(V)&#8239; > &#8239;MMA(V)&#8239; > &#8239;inorganic As species. The
loading patterns of both inorganic and organic As species into the rice
grains are largely dependent on the genetic makeup and maturity stage of
the rice plants together with environmental interactions. The knowledge of
As metabolism in rice plants and how it is affected by plant genetics and
environmental factors would pave the way to develop adaptive strategies to
minimize the accumulation of As in rice grains.
KW - Arsenic metabolism
KW - Arsenic speciation
KW - Arsenic toxicity
KW - Arsenic transporters
KW - Detoxification
KW - Grain filling
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
PT - Review
TA - Sci Total Environ
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180613
STAT- Publisher
DOCNO- medline/29908507

100 - TOXLINE
TI - Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in
Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus
Striatum.
AU - Srivastava P
AD - School of Pharmacy, Babu Banarasi Das University, BBD City, Faizabad Road,
Lucknow, 227 015, India.
AU - Dhuriya YK
AD - Developmental Toxicology Laboratory, Systems Toxicology and Health Risk
Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR),
Vishvigyan Bhawan; 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226 001, India.
AU - Gupta R
AD - School of Pharmacy, Babu Banarasi Das University, BBD City, Faizabad Road,
Lucknow, 227 015, India.
AU - Shukla RK
AD - Developmental Toxicology Laboratory, Systems Toxicology and Health Risk
Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR),
Vishvigyan Bhawan; 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226 001, India.
AU - Yadav RS
AD - Department of Criminology and Forensic Science, School of Applied Sciences,
Dr. Harisingh Gour Central University, Sagar, Madhya Pradesh, 470 003, India.
AU - Dwivedi HN
AD - School of Pharmacy, Babu Banarasi Das University, BBD City, Faizabad Road,
Lucknow, 227 015, India.
AU - Pant AB
AD - Developmental Toxicology Laboratory, Systems Toxicology and Health Risk
Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR),
Vishvigyan Bhawan; 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226 001, India.
AU - Khanna VK
AD - Developmental Toxicology Laboratory, Systems Toxicology and Health Risk
Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR),
Vishvigyan Bhawan; 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh, 226 001, India.
vkkhanna1@iitr.res.in.
SO - Mol Neurobiol. 2018, Jan; 55(1):445-461. [Molecular neurobiology]
AB - Earlier, protective role of curcumin in arsenic-induced dopamine (DA)-D2
receptor dysfunctions in corpus striatum has been demonstrated by us. In
continuation to that, the present study is focused to decipher the
molecular mechanisms associated with alterations in dopaminergic signaling
on arsenic exposure in corpus striatum and assess the protective efficacy
of curcumin. Exposure to arsenic (20 mg/kg, body weight p.o. for
28 days) in rats resulted to decrease the expression of presynaptic
proteins-tyrosine hydroxylase and VMAT2 while no effect was observed on
the expression of DAT in comparison to controls. A significant decrease in
the expression of DA-D2 receptors associated with alterations in the
expression of PKA, pDARPP32 (Thr 34), and PP1 &alpha; was clearly evident
on arsenic exposure. Expression of BDNF and pGSK3&beta; in corpus striatum
was found decreased in arsenic-exposed rats. Simultaneous treatment with
curcumin (100 mg/kg, body weight p.o. for 28 days) resulted to
protect arsenic-induced alterations in the expression of DA-D2 receptors,
PKA, pDARPP32, pCREB, and pPP1&alpha;. Neuroprotective efficacy of
curcumin can possibly be attributed to its antioxidant potential which
significantly protected arsenic-induced mitochondrial dysfunctions by
modulating the ROS generation and apoptosis. Modulation in the expression
of BDNF and pGSK3&beta; in corpus striatum by curcumin exhibits the
importance of neuronal survival pathway in arsenic-induced dopaminergic
dysfunctions. Interestingly, curcumin was also found to protect
arsenic-induced ultrastructural changes in corpus striatum. The results
exhibit that curcumin modulates BDNF/DARPP32/CREB in arsenic-induced
alterations in dopaminergic signaling in rat corpus striatum.
KW - Arsenic
KW - BDNF
KW - CREB
KW - Corpus striatum
KW - Curcumin
KW - DARPP32
KW - Dopamine
LA - eng
IS - 1559-1182 (Electronic)
PT - Journal Article
TA - Mol Neurobiol
YR - 2018
DATE- 20180219
CITO- NLM
CS - United States
FJT - Molecular neurobiology
EDAT- 20161213
STAT- In-Data-Review
CM - Cites: Neurotoxicol Teratol. 2010 Nov-Dec;32(6):640-7 (medline /20699118)
CM - Cites: Environ Int. 2007 Aug;33(6):805-11 (medline /17481731)
CM - Cites: Nature. 2001 Mar 15;410(6826):376-80 (medline /11268215)
CM - Cites: Free Radic Res. 2008 Jun;42(6):574-81 (medline /18569015)
CM - Cites: Food Chem Toxicol. 1997 Oct-Nov;35(10-11):1107-30 (medline
/9463546)
CM - Cites: Methods Enzymol. 1978;53:3-4 (medline /713841)
CM - Cites: Biochem Pharmacol. 2008 Sep 1;76(5):569-81 (medline /18555207)
CM - Cites: J Agric Food Chem. 2007 Feb 7;55(3):1039-44 (medline /17263510)
CM - Cites: Phytother Res. 2016 Feb;30(2):175-83 (medline /26610378)
CM - Cites: Toxicol Appl Pharmacol. 2009 Sep 1;239(2):169-77 (medline
/19121333)
CM - Cites: J Neurosci. 2004 Apr 28;24(17):4250-8 (medline /15115821)
CM - Cites: J Expo Sci Environ Epidemiol. 2016 Sep;26(5):464-70 (medline
/27072426)
CM - Cites: Toxicol Lett. 2002 Jul 7;133(1):1-16 (medline /12076506)
CM - Cites: Altern Ther Health Med. 2014 Winter;20 Suppl 1:18-25 (medline
/24473982)
CM - Cites: Curr Environ Health Rep. 2016 Mar;3(1):1-12 (medline /26875182)
CM - Cites: Toxicol Lett. 1990 Dec;54(2-3):345-53 (medline /2260129)
CM - Cites: Toxicol Lett. 2000 Sep 30;117(1-2):61-7 (medline /11033234)
CM - Cites: Toxicol Appl Pharmacol. 2014 Sep 15;279(3):428-40 (medline
/24952339)
CM - Cites: Environ Health Perspect. 2007 Sep;115(9):1371-5 (medline /17805430)
CM - Cites: Int J Dev Neurosci. 2014 May;34:60-75 (medline /24517892)
CM - Cites: J Biomed Sci. 2010 May 31;17:43 (medline /20513244)
CM - Cites: Toxicol Appl Pharmacol. 2011 Nov 1;256(3):241-8 (medline /21513725)
CM - Cites: Transl Neurodegener. 2012 Aug 20;1(1):16 (medline /23210631)
CM - Cites: Neurosci Lett. 1993 Oct 29;161(2):223-6 (medline /7903803)
CM - Cites: J Neurochem. 2011 Jan;116(1):1-9 (medline /21044077)
CM - Cites: Eur Rev Med Pharmacol Sci. 2013 May;17 (10 ):1360-8 (medline
/23740450)
CM - Cites: PLoS One. 2015 Sep 14;10 (9):e0137810 (medline /26368803)
CM - Cites: Indian J Pharm Sci. 2010 Mar;72(2):149-54 (medline /20838516)
CM - Cites: Rejuvenation Res. 2010 Feb;13(1):55-64 (medline /20230279)
CM - Cites: Toxicology. 2015 Feb 3;328:75-81 (medline /25496994)
CM - Cites: Biol Trace Elem Res. 2014 Dec;162(1-3):175-80 (medline /25319007)
CM - Cites: Toxicol Appl Pharmacol. 2009 Nov 1;240(3):367-76 (medline
/19631675)
CM - Cites: Br J Nutr. 2010 Jun;103(11):1545-57 (medline /20100380)
CM - Cites: Pharmacol Rev. 2011 Mar;63(1):182-217 (medline /21303898)
CM - Cites: Neuron. 1999 Jul;23(3):435-47 (medline /10433257)
CM - Cites: J Clin Psychopharmacol. 2015 Aug;35(4):406-10 (medline /26066335)
CM - Cites: Neurotoxicology. 2011 Dec;32(6):760-8 (medline /21839772)
CM - Cites: Food Chem Toxicol. 2013 Sep;59:739-47 (medline /23871787)
CM - Cites: PLoS One. 2012;7(3):e33057 (medline /22427945)
CM - Cites: Biochim Biophys Acta. 2012 Aug;1822(8):1207-15 (medline /22561904)
CM - Cites: Brain Res. 2009 Jul 28;1282:133-41 (medline /19445907)
CM - Cites: Front Cell Neurosci. 2014 Aug 28;8:254 (medline /25221473)
CM - Cites: Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1856-60 (medline
/10677546)
CM - Cites: Toxicology. 2014 Sep 2;323:78-94 (medline /24953689)
CM - Cites: Environ Sci Technol. 2003 Jan 15;37(2):229-34 (medline /12564892)
CM - Cites: Br J Nutr. 2016 Feb 14;115(3):449-65 (medline /26652155)
CM - Cites: Prog Neuropsychopharmacol Biol Psychiatry. 2010 Feb 1;34(1):147-53
(medline /19879308)
CM - Cites: Arch Toxicol. 2010 Jul;84(7):521-40 (medline /20224926)
CM -Cites: Appl Physiol Nutr Metab. 2014 Feb;39(2):211-8 (medline /24476477)
CM -Cites: Brain Res Bull. 2001 May 15;55(2):301-8 (medline /11470331)
CM -Cites: Neurotoxicology. 2010 Sep;31(5):533-9 (medline /20466022)
CM -Cites: PLoS One. 2013;8(3):e59843 (medline /23555802)
CM -Cites: Pharmacol Biochem Behav. 2016 Nov - Dec;150-151:39-47 (medline
/27619637)
CM - Cites: Toxicology. 2013 Aug 9;310:73-83 (medline /23702354)
CM - Cites: Curr Environ Health Rep. 2014 Mar 21;1:132-147 (medline /24860722)
CM - Cites: Sci Total Environ. 2000 Apr 17;249(1-3):297-312 (medline /10813460)
CM - Cites: Trends Mol Med. 2007 Aug;13(8):353-61 (medline /17644431)
CM - Cites: Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012 Feb;30(2):85-8
(medline /22801079)
CM - Cites: Mol Neurodegener. 2012 Apr 04;7:12 (medline /22475209)
CM - Cites: Eur Neuropsychopharmacol. 2015 Jan;25(1):38-50 (medline /25523883)
CM - Cites: Free Radic Res. 2005 Oct;39(10):1119-25 (medline /16298737)
CM - Cites: Transl Neurodegener. 2012 Jan 13;1(1):3 (medline /23210978)
CM - Cites: Neurotoxicology. 2014 Dec;45:159-67 (medline /25451969)
CM - Cites: Curr Opin Pharmacol. 2009 Feb;9(1):53-8 (medline /19138563)
CM - Cites: Biochem Pharmacol. 1966 Jul;15(7):977-87 (medline /5967909)
CM - Cites: Environ Health Perspect. 2013 Mar;121(3):295-302 (medline
/23458756)
CM - Cites: Neurosci Bull. 2012 Jun;28(3):253-8 (medline /22622825)
CM - Cites: Int J Epidemiol. 2011 Dec;40(6):1593-604 (medline /22158669)
CM - Cites: Nature. 2010 Dec 2;468(7324):696-700 (medline /21068725)
CM - Cites: Toxicol In Vitro. 2007 Sep;21(6):1104-12 (medline /17553662)
CM - Cites: Sci Total Environ. 2015 Sep 15;527-528:540-51 (medline /26004539)
CM - Cites: Free Radic Biol Med. 2008 Mar 1;44(5):907-17 (medline /18166164)
CM - Cites: Environ Res. 2015 Feb;137:329-37 (medline /25601736)
CM - Cites: J Health Popul Nutr. 2006 Jun;24(2):142-63 (medline /17195556)
CM - Cites: Neurotoxicology. 2003 Aug;24(4-5):747-53 (medline /12900089)
CM - Cites: Arch Toxicol. 2011 Feb;85(2):119-25 (medline /20571777)
CM - Cites: Cell Biochem Biophys. 2014 Nov;70(2):1433-8 (medline /24989681)
CM - Cites: Exp Neurol. 1999 Jan;155(1):109-17 (medline /9918710)
CM - Cites: Life Sci. 2006 Sep 13;79(16):1514-22 (medline /16737717)
DOCNO- medline/27966075

101 - TOXLINE
TI - Thiolated arsenic in natural systems: What is current, what is new and
what needs to be known.
AU - Herath I
AD - School of Civil Engineering and Surveying, Faculty of Health, Engineering and
Sciences, University of Southern Queensland, West Street, 4350 Toowoomba,
Queensland, Australia.
AU - Vithanage M
AD - International Centre for Applied Climate Science, University of Southern
Queensland, West Street, Toowoomba, 4350, Queensland, Australia; Faculty of Applied
Sciences, University of Sri Jayewardenepura, Nugegoda 10250, Sri Lanka.
AU - Seneweera S
AD - Plant Stress Biology Research Group, Centre for Crop Health, University of
Southern Queensland, West Street, Toowoomba, 4350, Queensland, Australia.
AU - Bundschuh J
AD - School of Civil Engineering and Surveying, Faculty of Health, Engineering and
Sciences, University of Southern Queensland, West Street, 4350 Toowoomba,
Queensland, Australia; UNESCO Chair on Groundwater Arsenic within the 2030 Agenda
for Sustainable Development, University of Southern Queensland, West Street, 4350
Toowoomba, Queensland, Australia. Electronic address: Jochen.Bundschuh@usq.edu.au.
SO - Environ Int. 2018, Jun; 115:370-386. [Environment international]
AB - Thiolated arsenic compounds are the sulfur analogous substructures of
oxo-arsenicals as the arsinoyl (As&#8239;=&#8239;O) is substituted by an
arsinothioyl (As&#8239;=&#8239;S) group. Relatively brief history of
thioarsenic research, mostly in the current decade has endeavored to
understand their consequences in the natural environment. However,
thioarsenic related aspects have by far not attached much research concern
on global scale compared to other arsenic species. This review attempts to
provide a critical overview for the first time on formation mechanisms of
thioarsenicals, their chemistry, speciation and analytical methodologies
in order to provide a rational assessment of what is new, what is current,
what needs to be known or what should be done in future research.
Thioarsenic compounds play a vital role in determining the biogeochemistry
of arsenic in sulfidic environments under reducing conditions. Thioarsenic
species are widely immobilized by naturally occurring processes such as
the adsorption on iron (oxyhydr)oxides and precipitation on iron sulfide
minerals. Accurate measurement of thioarsenic species is a challenging
task due to their instability upon pH, temperature, redox potential, and
concentrations of oxygen, sulfur and iron. Assessment of direct and
indirect effects of toxic thioarsenic species on global population those
who frequently get exposed to high levels of arsenic is an urgent
necessity. Dimethylmonothioarsinic acid (DMMTAV) is the most cytotoxic
arsenic metabolite having similar toxicological effects as
dimethylarsinous acid (DMAIII) in human and animal tissues. The formation
and chemical analysis of thioarsenicals in soil and sediments are highly
unknown. Therefore, future research needs to be more inclined towards in
determining the molecular structure of unknown thioarsenic complexes in
various environmental suites. Contemporary approaches hyphenated to
existing technologies would pave the way to overcome critical challenges
of thioarsenic speciation such as standards synthesis, structural
determination, quantification and sample preservation in future research.
KW - Arsenic
KW - Kinetics
KW - Speciation
KW - Thermodynamics
KW - Thioarsenicals
KW - Thiolation
LA - eng
IS - 1873-6750 (Electronic)
PT - Journal Article
PT - Review
TA - Environ Int
YR - 2018
DATE- 20180525
CI - Crown Copyright &copy; 2018. Published by Elsevier Ltd. All rights
reserved.
CITO- NLM
CS - Netherlands
FJT - Environment international
EDAT- 20180502
STAT- In-Data-Review
DOCNO- medline/29705693

102 - TOXLINE
TI - Effects of arsenolipids on in vitro blood-brain barrier model.
AU - M�ller SM
AD - Heinrich-Stockmeyer Foundation, Parkstra&szlig;e 44-46, 49214, Bad
Rothenfelde, Germany.
AU - Ebert F
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany.
AU - Raber G
AD - Institute of Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1,
8010, Graz, Austria.
AU - Meyer S
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany.
AU - Bornhorst J
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany.
AU - H�wel S
AD - Institute of Biochemistry, University of M�nster, Wilhelm-Klemm-Str. 2,
48149, M�nster, Germany.
AU - Galla HJ
AD - Institute of Biochemistry, University of M�nster, Wilhelm-Klemm-Str. 2,
48149, M�nster, Germany.
AU - Francesconi KA
AD - Institute of Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1,
8010, Graz, Austria.
AU - Schwerdtle T
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany. tanja.schwerdtle@uni-potsdam.de.
SO - Arch Toxicol. 2018, Feb; 92(2):823-832. [Archives of toxicology]
AB - Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids (AsLs)
occurring in fish and edible algae, possess a substantial neurotoxic
potential in fully differentiated human brain cells. Previous in vivo
studies indicating that AsHCs cross the blood-brain barrier of the fruit
fly Drosophila melanogaster raised the question whether AsLs could also
cross the vertebrate blood-brain barrier (BBB). In the present study, we
investigated the impact of several representatives of AsLs (AsHC 332, AsHC
360, AsHC 444, and two arsenic-containing fatty acids, AsFA 362 and AsFA
388) as well as of their metabolites (thio/oxo-dimethylpropionic acid,
dimethylarsinic acid) on porcine brain capillary endothelial cells
(PBCECs, in vitro model for the blood-brain barrier). AsHCs exerted the
strongest cytotoxic effects of all investigated arsenicals as they were up
to fivefold more potent than the toxic reference species arsenite
(iAsIII). In our in vitro BBB-model, we observed a slight transfer of AsHC
332 across the BBB after 6 h at concentrations that do not affect the
barrier integrity. Furthermore, incubation with AsHCs for 72 h led to
a disruption of the barrier at sub-cytotoxic concentrations. The
subsequent immunocytochemical staining of three tight junction proteins
revealed a significant impact on the cell membrane. Because AsHCs enhance
the permeability of the in vitro blood-brain barrier, a similar behavior
in an in vivo system cannot be excluded. Consequently, AsHCs might
facilitate the transfer of accompanying foodborne toxicants into the
brain.
KW - Arsenic-containing fatty acids
KW - Arsenic-containing hydrocarbons
KW - Arsenolipids
KW - In vitro blood–brain barrier model
LA - eng
IS - 1432-0738 (Electronic)
PT - Journal Article
TA - Arch Toxicol
YR - 2018
DATE- 20180220
CITO- NLM
CS - Germany
FJT - Archives of toxicology
EDAT- 20171020
STAT- In-Data-Review
DOCNO- medline/29058019

103 - TOXLINE
TI - Influence of operating parameters on arsenic transformation during
municipal sewage sludge incineration with cotton stalk.
AU - Zhao Y
AD - Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing,
100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
AU - Ren Q
AD - Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing,
100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Electronic address: renqiangqiang@iet.cn.
AU - Na Y
AD - Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing,
100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
SO - Chemosphere. 2018, Feb; 193:951-957. [Chemosphere]
AB - Addition of cotton stalk (CS) has been proved to promote dramatically the
transformation of toxic As3+ to less toxic As5+ in the fly ash during
municipal sewage sludge (MSS) incineration. However, the fate of arsenic
during co-firing of MSS and CS in different operating parameters was still
unclear. In the present study, the effects of incineration temperatures
and O2 content in the flue gas on speciation transformation of arsenic
during MSS and 70% MSS/30% CS incineration were investigated in a bubbling
fluidized bed. The results show that less arsenic is distributed in bottom
ash whereas more arsenic is migrated to the fly ash and flue gas, with the
temperature increasing from 800 &deg;C to 950 &deg;C. The
arsenic capture in fly ash is facilitated predominantly by the
condensation and/or physical adsorption of As2O3(g) at the temperatures
from 800 &deg;C to 900 &deg;C. The chemical oxidation of
As2O3(g) is favored by forming various arsenates (As5+) at
950 &deg;C. At low O2 content from 1% to 5%, some arsenic compounds
in MSS such as As2S3 can react with O2 to produce As2O3(g), and then more
As2O3(g) is captured in the fly ash by the inherent mineral compounds like
CaO through the condensation and/or physical adsorption. Further
increasing O2 content especially to 9% stimulates significantly the
oxidation of As3+ to As5+ in the fly ash, which is mainly attributed to
the chemical reactions between As2O3(g), various mineral compounds and
sufficient O2.
KW - Arsenic speciation transformation
KW - Cotton stalk
KW - Flue gas
KW - Incineration temperature
KW - Municipal sewage sludge
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180607
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20171123
STAT- In-Process
DOCNO- medline/29874771

104 - TOXLINE
TI - Arsenic, cadmium, lead, and chromium in well water, rice, and human urine
in Sri Lanka in relation to chronic kidney disease of unknown etiology.
AU - S Herath HMA
AD - Department of Environmental Engineering, Faculty of Engineering, Toyama
Prefectural University, 5180 Kurokawa, Imizu-city, Toyama 939-0398, Japan E-mail:
sunaliherath@gmail.com.
AU - Kawakami T
AD - Department of Environmental Engineering, Faculty of Engineering, Toyama
Prefectural University, 5180 Kurokawa, Imizu-city, Toyama 939-0398, Japan E-mail:
sunaliherath@gmail.com.
AU - Nagasawa S
AD - Department of Environmental Engineering, Faculty of Engineering, Toyama
Prefectural University, 5180 Kurokawa, Imizu-city, Toyama 939-0398, Japan E-mail:
sunaliherath@gmail.com.
AU - Serikawa Y
AD - Department of Environmental Engineering, Faculty of Engineering, Toyama
Prefectural University, 5180 Kurokawa, Imizu-city, Toyama 939-0398, Japan E-mail:
sunaliherath@gmail.com.
AU - Motoyama A
AD - Graduate School of Gifu University, 1-1 Yanagido, Gifu City 501-1193, Japan.
AU - Chaminda GGT
AD - Department of Civil &amp; Environmental Engineering, Faculty of Engineering,
University of Ruhuna, Hapugala, Galle, Sri Lanka.
AU - Weragoda SK
AD - National Water Supply and Drainage Board, Sri Lanka.
AU - Yatigammana SK
AD - Department of Zoology, Faculty of Science, University of Peradeniya,
Peradeniya, Sri Lanka.
AU - Amarasooriya AAGD
AD - Department of Environmental Engineering, Faculty of Engineering, Toyama
Prefectural University, 5180 Kurokawa, Imizu-city, Toyama 939-0398, Japan E-mail:
sunaliherath@gmail.com.
SO - J Water Health. 2018, Apr; 16(2):212-222. [Journal of water and health]
AB - Chronic kidney disease of unknown etiology (CKDu) is spreading gradually
in Sri Lanka. In the current research, 1,435 well water samples from all
25 districts of Sri Lanka, 91 rice samples, and 84 human urine samples
from both CKDu-endemic and non-endemic areas in Sri Lanka were analyzed
for arsenic, cadmium, lead, and chromium to detect whether toxic elements
could be a cause of CKDu. The liver-type fatty acid binding protein
(L-FABP) concentration and arsenic, cadmium, lead, and chromium
concentrations of the urine samples were analyzed to determine the
relation of L-FABP with arsenic, cadmium, lead, and chromium. High
concentrations of arsenic, cadmium, lead, and chromium were not detected
in the well water samples from CKDu-endemic areas. Arsenic, cadmium, and
lead contents in the rice samples from both CKDu-endemic and non-endemic
areas were well below the Codex standard. There were no relationships
between the L-FABP concentration and concentrations of arsenic, cadmium,
lead, and chromium in urine. In addition, arsenic, cadmium, lead, and
chromium concentrations in human urine samples from CKDu-endemic areas
were not significantly different from those from non-endemic areas. These
findings indicated that arsenic, cadmium, lead, and chromium could not
cause CKDu.
LA - eng
IS - 1477-8920 (Print)
PT - Journal Article
TA - J Water Health
YR - 2018
DATE- 20180420
CITO- NLM
CS - England
FJT - Journal of water and health
STAT- In-Data-Review
DOCNO- medline/29676757

105 - TOXLINE
TI - Lead, cadmium and arsenic in human milk and their socio-demographic and
lifestyle determinants in Lebanon.
AU - Bassil M
AD - Department of Natural Sciences, School of Arts and Sciences, Lebanese
American University, Beirut, 1102-2801, Lebanon.
AU - Daou F
AD - Department of Laboratory Science and Technology, American University of
Science and Technology, Achrafieh, 16-6452, Lebanon.
AU - Hassan H
AD - Department of Natural Sciences, School of Arts and Sciences, Lebanese
American University, Beirut, 1102-2801, Lebanon.
AU - Yamani O
AD - Department of Laboratory Science and Technology, American University of
Science and Technology, Achrafieh, 16-6452, Lebanon.
AU - Kharma JA
AD - Department of Natural Sciences, School of Arts and Sciences, Lebanese
American University, Beirut, 1102-2801, Lebanon.
AU - Attieh Z
AD - Department of Laboratory Science and Technology, American University of
Science and Technology, Achrafieh, 16-6452, Lebanon.
AU - Elaridi J
AD - Department of Natural Sciences, School of Arts and Sciences, Lebanese
American University, Beirut, 1102-2801, Lebanon. Electronic address:
Jomana.aridi@lau.edu.lb.
SO - Chemosphere. 2018, Jan; 191:911-921. [Chemosphere]
AB - INTRODUCTION: Exposure of newborns to toxic metals is of special interest
due to their reported contamination in breast milk and potential harm. The
aim of this study was to assess the occurrence and factors associated with
lead, cadmium and arsenic contamination in breast milk collected from
lactating mothers in Lebanon.
AB - METHODS: A total of 74 breast milk samples were collected from primaparas
according to guidelines set by the World Health Organization. A survey was
administered to determine the demographic and anthropometric
characteristics of participating lactating mothers. Dietary habits were
assessed using a semi-quantitative food frequency questionnaire. The milk
samples were analyzed for the presence of arsenic, cadmium and lead using
microwave-assisted digestion and atomic absorption spectrophotometry.
AB - RESULTS: Arsenic contamination was found in 63.51% of breast milk samples
(mean 2.36 &plusmn; 1.95 &mu;g/L) whereas cadmium and lead
were detected in 40.54% and 67.61% of samples respectively (means
0.87 &plusmn; 1.18 &mu;g/L and
18.18 &plusmn; 13.31 &mu;g/L). Regression analysis
indicated that arsenic contamination was associated with cereal and fish
intake (p = 0.013 and p = 0.042 respectively).
Residence near cultivation activities (p = 0.008), smoking
status before pregnancy (p = 0.046), potato consumption
(p = 0.046) and education level (p = 0.041) were
associated with lead contamination. Cadmium contamination was
significantly associated with random smoke exposure (p = 0.002).
AB - CONCLUSION: Our study is the first in Lebanon to report toxic metal
contamination in breast milk. Although estimated weekly infant intake of
these metals from breast milk was found to be lower than the limit set by
international guidelines, our results highlight the need for developing
strategies to protect infants from exposure to these hazardous substances.
KW - Arsenic
KW - Breast milk
KW - Cadmium
KW - Determinants
KW - Lead
KW - Lebanon
RN - 00BH33GNGH
RN - 2P299V784P
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180321
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171027
STAT- MEDLINE
DOCNO- medline/29145136

106 - TOXLINE
TI - Differentially Expressed mRNA Targets of Differentially Expressed miRNAs
Predict Changes in the TP53 Axis and Carcinogenesis-Related Pathways in
Human Keratinocytes Chronically Exposed to Arsenic.
AU - Al-Eryani L
AD - Department of Pharmacology and Toxicology.
AU - Waigel S
AD - Department of Medicine.
AU - Tyagi A
AD - Department of Urology, University of Louisville, Louisville, Kentucky 40202.
AU - Peremarti J
AD - Universitat Aut�noma de Barcelona, 08193 Bellaterra, Spain.
AU - Jenkins SF
AD - Department of Pharmacology and Toxicology.
AU - Damodaran C
AD - Department of Urology, University of Louisville, Louisville, Kentucky 40202.
AU - States JC
AD - Department of Pharmacology and Toxicology.
SO - Toxicol Sci. 2018, Apr 01; 162(2):645-654. [Toxicological sciences : an
official journal of the Society of Toxicology]
AB - Arsenic is a widely distributed toxic natural element. Chronic arsenic
ingestion causes several cancers, especially skin cancer. Arsenic-induced
cancer mechanisms are not well defined, but several studies indicate that
mutation is not the driving force and that microRNA expression changes
play a role. Chronic low arsenite exposure malignantly transforms
immortalized human keratinocytes (HaCaT), serving as a model for
arsenic-induced skin carcinogenesis. Early changes in miRNA expression in
HaCaT cells chronically exposed to arsenite will reveal early steps in
transformation. HaCaT cells were maintained with 0/100&thinsp;nM NaAsO2
for 3 and 7&thinsp;weeks. Total RNA was purified. miRNA and mRNA
expression was assayed using Affymetrix microarrays. Targets of
differentially expressed miRNAs were collected from TargetScan 6.2,
intersected with differentially expressed mRNAs using Partek Genomic Suite
software, and mapped to their pathways using MetaCore software. MDM2,
HMGB1 and TP53 mRNA, and protein levels were assayed by RT-qPCR and
Western blot. Numerous miRNAs and mRNAs involved in carcinogenesis
pathways in other systems were differentially expressed at 3 and
7&thinsp;weeks. A TP53 regulatory network including MDM2 and HMGB1 was
predicted by the miRNA and mRNA networks. Total TP53 and
TP53-S15-phosphorylation were induced. However, TP53-K382-hypoacetylation
suggested that the induced TP53 is inactive in arsenic exposed cells. Our
data provide strong evidence that early changes in miRNAs and target mRNAs
may contribute to arsenic-induced carcinogenesis.
LA - eng
IS - 1096-0929 (Electronic)
PT - Journal Article
TA - Toxicol Sci
YR - 2018
DATE- 20180518
CITO- NLM
CS - United States
FJT - Toxicological sciences : an official journal of the Society of Toxicology
STAT- In-Data-Review
CM - Cites: Cancer Res. 2008 Nov 15;68(22):9131-6 (medline /19010883)
CM - Cites: Toxicol Lett. 2014 Jun 5;227(2):91-8 (medline /24704393)
CM - Cites: Comp Med. 2011 Feb;61(1):39-44 (medline /21819680)
CM - Cites: J Biol Chem. 2009 Apr 24;284(17 ):11171-83 (medline /19265193)
CM - Cites: Cancer Res. 2001 Apr 1;61(7):3212-9 (medline /11306511)
CM - Cites: Cancer Cell. 2002 Jul;2(1):9-15 (medline /12150820)
CM - Cites: Oncotarget. 2012 Feb;3(2):132-43 (medline /22361592)
CM - Cites: Toxicol Sci. 2007 Sep;99(1):126-40 (medline /17567589)
CM - Cites: PLoS One. 2013 Aug 09;8(8):e71730 (medline /23951231)
CM - Cites: Curr Drug Targets. 2013 Sep;14(10):1128-34 (medline /23834148)
CM - Cites: Cell Mol Biol (Noisy-le-grand). 2016 Sep 30;62(11):13-20 (medline
/27755946)
CM - Cites: J Genet Genomics. 2009 Aug;36(8):447-54 (medline /19683667)
CM - Cites: Mol Cell. 2010 Apr 9;38(1):140-53 (medline /20385095)
CM - Cites: Clin Cancer Res. 2008 Sep 1;14 (17 ):5318-24 (medline /18765522)
CM - Cites: Rev Diabet Stud. 2012 Spring;9(1):6-22 (medline /22972441)
CM - Cites: J Cutan Pathol. 1998 Oct;25(9):457-62 (medline /9821074)
CM - Cites: Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2259-64 (medline
/14982997)
CM - Cites: Cancer Invest. 2008 Oct;26(8):843-51 (medline /18798064)
CM - Cites: Mol Cell Biochem. 2007 Oct;304(1-2):219-26 (medline /17530187)
CM - Cites: Mol Med Rep. 2014 Oct;10(4):1663-70 (medline /25069581)
CM - Cites: Oncol Lett. 2013 Mar;5(3):884-888 (medline /23426143)
CM - Cites: J Biol Chem. 2002 Mar 1;277(9):7157-64 (medline /11748232)
CM - Cites: Front Genet. 2012 Jan 09;2:91 (medline /22303385)
CM - Cites: J Cell Physiol. 2014 Nov;229(11):1630-8 (medline /24610393)
CM - Cites: Int J Cancer. 2001 May 20;95(3):168-75 (medline /11307150)
CM - Cites: Toxicology. 2009 Aug 3;262(2):162-70 (medline /19524636)
CM - Cites: Curr Genomics. 2010 Nov;11(7):537-61 (medline /21532838)
CM - Cites: Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):131-40 (medline
/20123075)
CM - Cites: Oncol Lett. 2012 Aug;4(2):339-345 (medline /22844381)
CM - Cites: Clin Cancer Drugs. 2015;2(2):138-147 (medline /27054085)
CM - Cites: Int J Cancer. 2001 Jun 15;92 (6):790-6 (medline /11351297)
CM - Cites: Free Radic Biol Med. 2008 Sep 1;45(5):651-8 (medline /18572023)
CM - Cites: Mol Cancer Res. 2007 Apr;5(4):403-12 (medline /17426254)
CM - Cites: Mol Cancer Res. 2003 Dec;1(14 ):1001-8 (medline /14707283)
CM - Cites: Exp Dermatol. 2013 Jun;22(6):426-8 (medline /23711067)
CM - Cites: EMBO Mol Med. 2012 Mar;4(3):143-59 (medline /22351564)
CM - Cites: Mol Ther. 2007 Dec;15(12):2070-9 (medline /17878899)
CM - Cites: Br J Cancer. 1999 Jun;80(7):1080-6 (medline /10362120)
CM -Cites: Mol Cell Biol. 2014 Sep 15;34(18):3407-20 (medline /24980435)
CM -Cites: Cell. 1993 Dec 3;75(5):843-54 (medline /8252621)
CM -Cites: Annu Rev Public Health. 2009;30:107-22 (medline /19012537)
CM -Cites: Cancers (Basel). 2016 Jul 20;8(7):null (medline /27447672)
CM -Cites: J Thorac Oncol. 2011 Mar;6(3):482-8 (medline /21258252)
CM -Cites: Diabetes. 2013 Mar;62(3):789-800 (medline /22966074)
CM -Cites: Cancer Lett. 2014 Nov 28;354(2):211-9 (medline /25173797)
CM -Cites: FEBS Lett. 1997 Dec 22;420(1):25-7 (medline /9450543)
CM -Cites: Histopathology. 2015 Oct;67(4):491-500 (medline /25684546)
CM -Cites: Genes Dev. 1998 Sep 15;12(18):2831-41 (medline /9744860)
CM -Cites: Int J Clin Exp Pathol. 2015 Sep 01;8(9):11258-67 (medline
/26617850)
CM - Cites: Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a002881 (medline
/20066091)
CM - Cites: FEBS J. 2011 May;278(10):1598-609 (medline /21395977)
CM - Cites: Nat Med. 1996 Aug;2(8):912-7 (medline /8705862)
CM - Cites: Cancer Res. 1998 Feb 15;58(4):609-13 (medline /9485008)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt C):11-465 (medline
/23189751)
CM - Cites: Cell. 1997 Oct 31;91(3):325-34 (medline /9363941)
CM - Cites: Dermatol Surg. 1996 Mar;22(3):301-4 (medline /8599743)
CM - Cites: Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5117-22 (medline
/10220428)
CM - Cites: Int J Oncol. 2001 Sep;19(3):625-32 (medline /11494046)
CM - Cites: Science. 2001 Oct 26;294(5543):853-8 (medline /11679670)
CM - Cites: Hippokratia. 2010 Oct;14(4):236-40 (medline /21311629)
CM - Cites: Mol Cell Biol. 2003 Apr;23(8):2991-8 (medline /12665595)
CM - Cites: Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10124-8 (medline
/1946433)
CM - Cites: Environ Health Perspect. 2002 Oct;110 Suppl 5:883-6 (medline
/12426152)
CM - Cites: Environ Sci. 2005;12(5):283-92 (medline /16308561)
CM - Cites: Carcinogenesis. 1993 May;14(5):833-9 (medline /8504475)
CM - Cites: Cancer J. 2012 May-Jun;18(3):223-31 (medline /22647358)
CM - Cites: Oncol Res. 1998;10(9):475-82 (medline /10223623)
CM - Cites: J Cell Biol. 1988 Mar;106(3):761-71 (medline /2450098)
CM - Cites: Cell. 1997 Aug 22;90(4):595-606 (medline /9288740)
CM - Cites: Int J Clin Exp Pathol. 2015 Jun 01;8(6):6646-55 (medline /26261546)
CM - Cites: Nat Rev Cancer. 2012 Jan 19;12 (2):84-8 (medline /22257949)
CM - Cites: Biol Trace Elem Res. 2015 Jul;166(1):34-40 (medline /25796515)
CM - Cites: Biomark Insights. 2012;7:127-41 (medline /23115478)
CM - Cites: Cancer Cell Int. 2015 Sep 17;15:87 (medline /26388702)
CM - Cites: Nat Commun. 2013;4:2996 (medline /24356649)
CM - Cites: Asian Pac J Cancer Prev. 2007 Jan-Mar;8(1):13-23 (medline
/17477765)
DOCNO- medline/29319823

107 - TOXLINE
TI - Impact of prenatal arsenic exposure on chronic adult diseases.
AU - Young JL
AD - a Department of Pharmacology and Toxicology , University of Louisville ,
Louisville , KY , USA.
AU - Cai L
AD - b Departments of Pediatrics, Radiation Oncology and pharmacology and
Toxicology , Pediatric Research Institute, University of Louisville , Louisville ,
KY , USA.
AU - States JC
AD - a Department of Pharmacology and Toxicology , University of Louisville ,
Louisville , KY , USA.
SO - Syst Biol Reprod Med. 2018, Jun 06:1-15. [Systems biology in reproductive
medicine]
AB - Exposure to environmental stressors during susceptible windows of
development can result in negative health outcomes later in life, a
concept known as the Developmental Origins of Health and Disease (DOHaD).
There is a growing body of evidence that exposures to metals early in life
(in utero and postnatal) increase the risk of developing adult diseases
such as cancer, cardiovascular disease, non-alcoholic fatty liver disease,
and diabetes. Of particular concern is exposure to the metalloid arsenic,
a drinking water contaminant and worldwide health concern. Epidemiological
studies of areas with high levels of arsenic in the drinking water, such
as some regions in Chile and Bangladesh, indicate an association between
in utero arsenic exposure and the development of adult diseases.
Therefore, the need for experimental models to address the mechanism
underlining early onset of adult diseases have emerged including the in
utero and whole-life exposure models. This review will highlight the
epidemiological events and subsequent novel experimental models
implemented to study the impact of early life exposure to arsenic on the
development of adult diseases. In addition, current research using these
models will be discussed as well as possible underlying mechanism for the
early onset of disease.
AB - ABBREVIATIONS: ALT: alanine aminotransferase; AMI: acute myocardial
infarction; AST: aspartate aminotransferase; ATSDR: Agency for Toxic
Substances and Disease Registry; CVD: cardiovascular disease; DMA:
dimethylarsinate; DOHaD: Developmental Origins of Health and Disease; EPA:
U.S. Environmental Protection Agency; ER-&alpha;: estrogen receptor alpha;
HDL: high-density lipoprotein; HOMA-IR: homeostatic model assessment of
insulin resistance; iAs: inorganic arsenic; LDL: low-density lipoprotein;
MetS: metabolic syndrome; MMA: monomethylarsonate; NAFLD: non-alcoholic
fatty liver disease; PND: postnatal day; ppb: parts per billion; ppm:
parts per million; SAM: S-adenosylmethionine; USFDA: United States Food
and Drug Administration.
KW - Arsenic
KW - cancer
KW - cardiovascular disease
KW - chronic adult disease
KW - prenatal exposure
LA - eng
IS - 1939-6376 (Electronic)
PT - Journal Article
TA - Syst Biol Reprod Med
YR - 2018
DATE- 20180606
CITO- NLM
CS - England
FJT - Systems biology in reproductive medicine
EDAT- 20180606
STAT- Publisher
DOCNO- medline/29873257

108 - TOXLINE
TI - Melatonin attenuates arsenic induced nephropathy via the regulation of
oxidative stress and inflammatory signaling cascades in mice.
AU - Dutta S
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata 700054, India.
AU - Saha S
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata 700054, India.
AU - Mahalanobish S
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata 700054, India.
AU - Sadhukhan P
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata 700054, India.
AU - Sil PC
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata 700054, India. Electronic address: parames@jcbose.ac.in.
SO - Food Chem Toxicol. 2018, May 12; 118:303-316. [Food and chemical
toxicology : an international journal published for the British Industrial
Biological Research Association]
AB - Arsenic is a potent inducer of several acute and chronic nephrotoxic
disorders. It promotes deleterious phenomenon like oxidative stress,
inflammation, cell death and altered glucose uptake leading to distorted
kidney homeostasis that end up in chronic kidney disease. This study
investigated the possible protective role of melatonin; a natural
antioxidant produced by the pineal gland, against arsenic induced
nephrotoxicity. Melatonin successfully ameliorated arsenic induced renal
toxicity both in in vitro and in vivo models. Elevated BUN, creatinine,
urine glucose and protein levels and altered renal histopathological
conditions were observed in arsenic intoxicated mice. Significant
oxidative stress induced damage of biomolecules along with downregulation
in antioxidant enzymes and thiols were also detected in the kidney tissues
of arsenic-intoxicated mice. These alterations along with mitochondrial
dysfunction ultimately triggered TNF&alpha; mediated inflammatory and cell
death cascades. Interestingly arsenic also led to disruption of glucose
uptake in the kidney. These findings suggest that melatonin protects the
kidney against toxic effect of arsenic, presumably through its
antioxidant, anti-inflammatory and antidiabetic properties by inhibiting
inflammatory outburst, apoptosis, necroptosis and stimulating glucose
uptake. As melatonin is a natural antioxidant molecule, detailed
pharmacokinetic and pharmacodynamic studies are expected to establish it
as an effective nephro-protective agent in future.
KW - Apoptosis
KW - Arsenic
KW - Glucose uptake
KW - Inflammation
KW - Kidney
KW - Melatonin
KW - Necroptosis
KW - Oxidative stress
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180512
STAT- Publisher
DOCNO- medline/29763682

109 - TOXLINE
TI - Arsenic-gene interactions and beta-cell function in the Strong Heart
Family Study.
AU - Balakrishnan P
AD - Department of Environmental Health Sciences, Columbia University Mailman
School of Public Health, New York, NY, United States.
AU - Navas-Acien A
AD - Department of Environmental Health Sciences, Columbia University Mailman
School of Public Health, New York, NY, United States.
AU - Haack K
AD - Texas Biomedical Research Institute, San Antonio, TX, United States.
AU - Vaidya D
AD - Department of Epidemiology, Johns Hopkins University Bloomberg School of
Public Health, Baltimore, MD, United States; Clinical and Translational Research,
Johns Hopkins School of Medicine, Baltimore, MD, United States.
AU - Umans JG
AD - MedStar Health Research Institute, Hyattsville, MD, United States.
AU - Best LG
AD - Missouri Breaks Industries Research, Inc., Eagle Butte, SD, United States.
AU - Goessler W
AD - Institute of Chemistry, University of Graz, Graz, Austria.
AU - Francesconi KA
AD - Institute of Chemistry, University of Graz, Graz, Austria.
AU - Franceschini N
AD - Department of Epidemiology, University of North Carolina at Chapel Hill,
Chapel Hill, NC, United States.
AU - North KE
AD - Department of Epidemiology, University of North Carolina at Chapel Hill,
Chapel Hill, NC, United States.
AU - Cole SA
AD - Texas Biomedical Research Institute, San Antonio, TX, United States.
AU - Voruganti VS
AD - Department of Nutrition and UNC Nutrition Research Institute, University of
North Carolina at Chapel Hill, Kannapolis, NC, United States.
AU - Gribble MO
AD - Department of Environmental Health, Emory University Rollins School of Public
Health, Atlanta, GA, United States; Department of Epidemiology, Emory University
Rollins School of Public Health, Atlanta, GA, United States. Electronic address:
matt.gribble@emory.edu.
SO - Toxicol Appl Pharmacol. 2018, Jun 01; 348:123-129. [Toxicology and applied
pharmacology]
AB - We explored arsenic-gene interactions influencing pancreatic beta-cell
activity in the Strong Heart Family Study (SHFS). We considered 42
variants selected for associations with either beta-cell function (31
variants) or arsenic metabolism (11 variants) in the SHFS. Beta-cell
function was calculated as homeostatic model - beta corrected for insulin
resistance (cHOMA-B) by regressing homeostatic model - insulin resistance
(HOMA-IR) on HOMA-B and adding mean HOMA-B. Arsenic exposure was
dichotomized at the median of the sum of creatinine-corrected inorganic
and organic arsenic species measured by high performance liquid
chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS).
Additive GxE models for cHOMA-B were adjusted for age and ancestry, and
accounted for family relationships. Models were stratified by center
(Arizona, Oklahoma, North Dakota and South Dakota) and meta-analyzed. The
two interactions between higher vs. lower arsenic and SNPs for cHOMA-B
that were nominally significant at P&#8239; < &#8239;0.05 were with
rs10738708 (SNP overall effect -3.91, P&#8239;=&#8239;0.56; interaction
effect with arsenic -31.14, P&#8239;=&#8239;0.02) and rs4607517 (SNP
overall effect +16.61, P&#8239;=&#8239;0.03; interaction effect with
arsenic +27.02, P&#8239;=&#8239;0.03). The corresponding genes GCK and
TUSC1 suggest oxidative stress and apoptosis as possible mechanisms for
arsenic impacts on beta-cell function. No interactions were
Bonferroni-significant (1.16&#8239;&times;&#8239;10-3). Our findings are
suggestive of oligogenic moderation of arsenic impacts on pancreatic
&beta;-cell endocrine function, but were not Bonferroni-significant.
KW - Arsenicals
KW - Diabetes
KW - Environmental Epidemiology
KW - Genetic Epidemiology
KW - Pancreas
KW - Susceptibility
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180523
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20180403
STAT- In-Data-Review
CM - Cites: Trends Genet. 2017 Apr;33(4):244-255 (medline /28245910)
CM - Cites: PLoS Genet. 2012;8(8):e1002793 (medline /22876189)
CM - Cites: Environ Health Perspect. 2017 Jan;125(1):15-22 (medline /27352405)
CM - Cites: Diabetologia. 2011 Jun;54(6):1273-90 (medline /21442161)
CM - Cites: Diabetes Care. 2010 Nov;33(11):2370-7 (medline /20805255)
CM - Cites: Epigenomics. 2017 May;9(5):701-710 (medline /28470093)
CM - Cites: Environ Health Perspect. 2012 Dec;120(12 ):1658-70 (medline
/22889723)
CM - Cites: Am J Epidemiol. 1986 Jul;124(1):17-27 (medline /3521261)
CM - Cites: PLoS One. 2013 Jun 11;8(6):e66114 (medline /23776618)
CM - Cites: Hum Mutat. 2009 Nov;30(11):1512-26 (medline /19790256)
CM - Cites: Bioinformatics. 2010 Sep 1;26(17):2190-1 (medline /20616382)
CM - Cites: J Biol Chem. 2006 Mar 17;281(11):7364-73 (medline /16407288)
CM - Cites: Am J Epidemiol. 1990 Dec;132(6):1141-55 (medline /2260546)
CM - Cites: Curr Environ Health Rep. 2014 Jan 19;1:22-34 (medline /24860721)
CM - Cites: Nat Genet. 2002 Jan;30(1):97-101 (medline /11731797)
CM - Cites: Am J Hum Genet. 1998 May;62(5):1198-211 (medline /9545414)
CM - Cites: Nat Genet. 2012 May 13;44(6):659-69 (medline /22581228)
CM - Cites: Diabetes Technol Ther. 2010 Aug;12(8):599-604 (medline /20615100)
CM - Cites: Oncol Rep. 2014 Mar;31(3):1305-13 (medline /24366000)
CM - Cites: Anal Methods. 2012;4(2):406-413 (medline /22685491)
CM - Cites: Am J Epidemiol. 2003 Feb 15;157(4):303-14 (medline /12578801)
CM - Cites: Environ Health Perspect. 2017 Dec 20;125(12 ):127004 (medline
/29373862)
CM - Cites: Nat Genet. 2010 Feb;42(2):105-16 (medline /20081858)
CM - Cites: Diabetologia. 1985 Jul;28(7):412-9 (medline /3899825)
DOCNO- medline/29621497

110 - TOXLINE
TI - Chronic exposure to high fat diet exacerbates arsenic-induced lung damages
in male mice: Possible role for oxidative stress.
AU - Hemmati AA
AD - Ahvaz Jundishapur University of Medical Sciences. Hemmati.AA@yahoo.com.
AU - Alboghobeish S
AD - Ahvaz Jundishapur University of Medical Sciences. Hemmati.AA@yahoo.com.
AU - Ahangarpour A
AD - Ahvaz Jundishapur University of Medical Sciences. Hemmati.AA@yahoo.com.
SO - Monaldi Arch Chest Dis. 2018, Mar 23; 88(1):903. [Monaldi archives for
chest disease = Archivio Monaldi per le malattie del torace]
AB - Arsenic is a common environmental and occupational contaminant worldwide
which can influence the development of respiratory diseases. In recent
years, alteration in the lifestyle as well as food habits have led to
increased consumption of food containing high levels of fat. The present
study was designed to evaluate the effects of chronic exposure to a
high-fat diet (HFD) on arsenic-induced damages and oxidative stress in the
lung tissue of mice. This is the first study to reveal the effect of
diet-induced obesity on arsenic-induced lung damages. Seventy-two male
Naval Medical Research Institute (NMRI) mice were divided into six groups
and fed an HFD or standard diet (SD) while being exposed to 25 or 50 ppm
of arsenic through drinking water for 20 weeks. At the end of the
experiment, the lung weight to body weight ratio; oxidative stress
markers, nitrite level, and hydroxyproline content in the lung tissue; and
lung histology were evaluated. The results demonstrated that arsenic
exposure leads to a significant decrease in the glutathione level and
catalase enzyme activity, and significantly increased reactive oxygen
species, malondialdehyde, and nitrite level, but it did not affect the
superoxide dismutase activity and hydroxyproline content in the lung
tissue. Consequently, all the parameters studied aggravated when HFD was
consumed along with arsenic. These findings were confirmed by histological
examination. Our study showed that HFD increased arsenic-induced lung
damages through oxidative stress in mice. These findings could be
important for clinical research to protect against arsenic-induced
respiratory toxicity in humans.
KW - Lung
KW - arsenic
KW - high fat diet
KW - oxidative stress.
LA - eng
IS - 1122-0643 (Print)
PT - Journal Article
TA - Monaldi Arch Chest Dis
YR - 2018
DATE- 20180509
CITO- NLM
CS - Italy
FJT - Monaldi archives for chest disease = Archivio Monaldi per le malattie del
torace
EDAT- 20180323
STAT- PubMed-not-MEDLINE
DOCNO- medline/29741077

111 - TOXLINE
TI - Multidrug Resistance Protein 1 (MRP1/ABCC1)-mediated cellular protection
and transport of methylated arsenic metabolites differs between human cell
lines.
AU - Banerjee M
AD - University of Alberta.
AU - Kaur G
AD - University of Alberta.
AU - Whitlock BD
AD - University of Alberta.
AU - Carew MW
AD - University of Alberta.
AU - Le XC
AD - University of Alberta.
AU - Leslie EM
AD - University of Alberta eleslie@ualberta.ca.
SO - Drug Metab Dispos. 2018, May 11. [Drug metabolism and disposition: the
biological fate of chemicals]
AB - The ATP-binding cassette (ABC) transporter Multidrug Resistance Protein 1
(MRP1/ABCC1) is known to protect cells from the proven human carcinogen
arsenic through the cellular efflux of arsenic triglutathione [As(GS)3],
and the diglutathione conjugate of the highly toxic monomethylarsonous
acid (MMAIII) [MMA(GS)2]. Previously, differences in MRP1 phosphorylation
(at Y920/S921) and N-glycosylation (at N19/N23) were associated with
marked differences in As(GS)3 transport kinetics between HEK293 and HeLa
cell lines. The objectives of the current study were to determine if
differences in MRP1-mediated cellular protection and transport of other
arsenic metabolites exist between HEK293 and HeLa cells. MRP1 expressed in
HEK293 cells conferred protection against the major urinary arsenic
metabolite dimethylarsinic acid (DMAV) through high apparent affinity and
capacity transport (Km 0.19 &mu;M, Vmax 342 pmol mg-1 protein min-1). In
contrast, DMAV transport was not detected using HeLa-WT-MRP1 membrane
vesicles. MMA(GS)2 transport by HeLa-WT-MRP1 vesicles had a similar
apparent Km, but a greater than 3-fold higher Vmax, compared to
HEK-WT-MRP1 vesicles. Cell line differences in DMAV and MMA(GS)2 transport
were not explained by differences in phosphorylation at Y920/S921. DMAV
did not inhibit, while MMA(GS)2 was an uncompetitive inhibitor of As(GS)3
transport, suggesting that DMAV and MMA(GS)2 have non-identical binding
sites to As(GS)3 on MRP1. Detoxification of different arsenic metabolites
by MRP1 is likely influenced by multiple factors including cell and tissue
type. This could have implications for the influence of MRP1 on both
tissue specific susceptibility to arsenic-induced disease, and tumour
sensitivity to arsenic-based therapeutics.
KW - Transporter-mediated drug/metabolite disposition
KW - carcinogen metabolism
KW - efflux transporters (P-gp, BCRP, MRP, MATE, BSEP, etc)
KW - glutathione
KW - heavy metals
KW - toxicology
LA - eng
IS - 1521-009X (Electronic)
PT - Journal Article
TA - Drug Metab Dispos
YR - 2018
DATE- 20180512
CI - The American Society for Pharmacology and Experimental Therapeutics.
CITO- NLM
CS - United States
FJT - Drug metabolism and disposition: the biological fate of chemicals
EDAT- 20180511
STAT- Publisher
DOCNO- medline/29752257

112 - TOXLINE
TI - Long-term exposure of immortalized keratinocytes to arsenic induces EMT,
impairs differentiation in organotypic skin models and mimics aspects of
human skin derangements.
AU - Weinmuellner R
AD - Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of
Biotechnology, BOKU - University of Natural Resources and Life Sciences Vienna,
Vienna, Austria.
AU - Kryeziu K
AD - Department of Medicine I, Institute of Cancer Research and Comprehensive
Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna,
Austria.
AU - Zbiral B
AD - Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of
Biotechnology, BOKU - University of Natural Resources and Life Sciences Vienna,
Vienna, Austria.
AU - Tav K
AD - Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of
Biotechnology, BOKU - University of Natural Resources and Life Sciences Vienna,
Vienna, Austria.
AU - Schoenhacker-Alte B
AD - Department of Medicine I, Institute of Cancer Research and Comprehensive
Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna,
Austria.
AU - Groza D
AD - Department of Medicine I, Institute of Cancer Research and Comprehensive
Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna,
Austria.
AU - Wimmer L
AD - Department of Medicine I, Institute of Cancer Research and Comprehensive
Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna,
Austria.
AU - Schosserer M
AD - Department of Biotechnology, BOKU - University of Natural Resources and Life
Sciences Vienna, Muthgasse 18, Haus B, 1190, Vienna, Austria.
AU - Nagelreiter F
AD - Department of Biotechnology, BOKU - University of Natural Resources and Life
Sciences Vienna, Muthgasse 18, Haus B, 1190, Vienna, Austria.
AU - R�singer S
AD - Christian Doppler Laboratory on Biotechnology of Skin Aging, Department of
Biotechnology, BOKU - University of Natural Resources and Life Sciences Vienna,
Vienna, Austria.
AU - Mildner M
AD - Department of Dermatology, Medical University of Vienna, Vienna, Austria.
AU - Tschachler E
AD - Department of Dermatology, Medical University of Vienna, Vienna, Austria.
AU - Grusch M
AD - Department of Medicine I, Institute of Cancer Research and Comprehensive
Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna,
Austria.
AU - Grillari J
AD - Department of Biotechnology, BOKU - University of Natural Resources and Life
Sciences Vienna, Muthgasse 18, Haus B, 1190, Vienna, Austria.
johannes.grillari@boku.ac.at.
AU - Heffeter P
AD - Department of Medicine I, Institute of Cancer Research and Comprehensive
Cancer Center Vienna, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna,
Austria. petra.heffeter@meduniwien.ac.at.
SO - Arch Toxicol. 2018, Jan; 92(1):181-194. [Archives of toxicology]
AB - Arsenic is one of the most important human carcinogens and environmental
pollutants. However, the evaluation of the underlying carcinogenic
mechanisms is challenging due to the lack of suitable in vivo and in vitro
models, as distinct interspecies differences in arsenic metabolism exist.
Thus, it is of high interest to develop new experimental models of
arsenic-induced skin tumorigenesis in humans. Consequently, aim of this
study was to establish an advanced 3D model for the investigation of
arsenic-induced skin derangements, namely skin equivalents, built from
immortalized human keratinocytes (NHEK/SVTERT3-5). In contrast to
spontaneously immortalized HACAT cells, NHEK/SVTERT3-5 cells more closely
resembled the differentiation pattern of primary keratinocytes. With
regard to arsenic, our results showed that while our new cell model was
widely unaffected by short-time treatment (72 h) with low, non-toxic
doses of ATO (0.05-0.25 &micro;M), chronic exposure (6 months)
resulted in distinct changes of several cell characteristics. Thus, we
observed an increase in the G2 fraction of the cell cycle accompanied by
increased nucleus size and uneven tubulin distribution. Moreover, cells
showed strong signs of de-differentiation and upregulation of several
epithelial-to-mesenchymal transition markers. In line with these effects,
chronic contact to arsenic resulted in impaired skin-forming capacities as
well as localization of ki67-positive (proliferating) cells at the upper
layers of the epidermis; a condition termed Bowen's disease. Finally,
chronically arsenic-exposed cells were characterized by an increased
tumorigenicity in SCID mice. Taken together, our study presents a new
model system for the investigation of mechanisms underlying the
tumor-promoting effects of chronic arsenic exposure.
KW - Arsenic
KW - EMT
KW - Immortalized keratinocytes
KW - Organotypic culture
KW - Skin equivalents
LA - eng
IS - 1432-0738 (Electronic)
PT - Journal Article
TA - Arch Toxicol
YR - 2018
DATE- 20180315
CITO- NLM
CS - Germany
FJT - Archives of toxicology
EDAT- 20170803
STAT- In-Data-Review
CM - Cites: J Clin Oncol. 2007 Jul 1;25(19):2735-40 (medline /17602078)
CM - Cites: Environ Health Perspect. 2007 Apr;115(4):513-8 (medline /17450217)
CM - Cites: Mutat Res. 1997 Jun;386(3):209-18 (medline /9219559)
CM - Cites: Toxicol Appl Pharmacol. 2013 Aug 15;271(1):20-9 (medline /23643801)
CM - Cites: Proteomics. 2017 Mar;17 (6):null (medline /28000977)
CM - Cites: PLoS One. 2013 Aug 30;8(8):e72457 (medline /24023619)
CM - Cites: Adv Drug Deliv Rev. 2014 Apr;69-70:81-102 (medline /24378581)
CM - Cites: Mol Biol Int. 2011;2011:718974 (medline /22091411)
CM - Cites: Am J Epidemiol. 2011 Feb 15;173(4):414-20 (medline /21190988)
CM - Cites: Cell. 2000 Jan 7;100(1):57-70 (medline /10647931)
CM - Cites: Bull World Health Organ. 2000;78(9):1093-103 (medline /11019458)
CM - Cites: Arch Toxicol. 2017 Nov;91(11):3507-3516 (medline /28470405)
CM - Cites: Kaohsiung J Med Sci. 2011 Sep;27(9):390-5 (medline /21914526)
CM - Cites: Science. 1988 Jul 1;241(4861):79-81 (medline /3388020)
CM - Cites: Chemosphere. 2016 Sep;158:37-49 (medline /27239969)
CM - Cites: Br J Dermatol. 2015 Aug;173(2):391-403 (medline /25939812)
CM - Cites: Crit Rev Toxicol. 2009;39(4):271-98 (medline /19235533)
CM - Cites: Cancer Lett. 2000 Apr 28;152(1):79-85 (medline /10754209)
CM - Cites: Arch Toxicol. 2013 Jun;87(6):991-1000 (medline /23069812)
CM - Cites: Cancer Lett. 2014 Nov 28;354(2):211-9 (medline /25173797)
CM - Cites: Biol Pharm Bull. 2001 May;24(5):510-4 (medline /11379771)
CM - Cites: Biochem Biophys Res Commun. 2006 Sep 15;348(1):76-82 (medline
/16875670)
CM - Cites: Biochem Pharmacol. 2007 Jun 15;73(12 ):1873-86 (medline /17445775)
CM - Cites: Arch Toxicol. 2016 Oct;90(10 ):2349-67 (medline /27353523)
CM - Cites: Environ Sci Pollut Res Int. 2017 Feb;24(6):5316-5325 (medline
/28013460)
CM - Cites: J Nutr Biochem. 2016 Dec;38:25-40 (medline /27723467)
CM -Cites: Methods Enzymol. 2016;569:287-308 (medline /26778564)
CM -Cites: ALTEX. 2014;31(4):441-77 (medline /25027500)
CM -Cites: Cancer Prev Res (Phila). 2015 Mar;8(3):208-21 (medline /25586904)
CM -Cites: Postgrad Med. 1964 May;35:503-11 (medline /14163260)
CM -Cites: Toxicol Appl Pharmacol. 2015 Jul 1;286(1):36-43 (medline /25804888)
CM -Cites: Int J Environ Res Public Health. 2017 Jan 14;14 (1): (medline
/28098817)
CM - Cites: Toxicol Appl Pharmacol. 2017 Sep 15;331:6-17 (medline /28336213)
CM - Cites: Toxicol Mech Methods. 2016 Oct;26(8):565-579 (medline /27580671)
CM - Cites: Environ Sci Technol. 2012 Apr 3;46(7):4142-8 (medline /22352724)
CM - Cites: Arch Toxicol. 2015 Dec;89(12 ):2229-41 (medline /25537191)
CM - Cites: BMJ. 2013 Jun 05;346:f3625 (medline /23741031)
CM - Cites: Int Immunol. 2015 Jun;27(6):269-80 (medline /25813515)
CM - Cites: Toxicol In Vitro. 1997 Feb-Apr;11(1-2):89-98 (medline /20654299)
DOCNO- medline/28776197

113 - TOXLINE
TI - Shielding effect of anethole against arsenic induced genotoxicity in
cultured human peripheral blood lymphocytes and effect of GSTO1
polymorphism.
AU - Bal S
AD - 1Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana
136119 India.
AU - Yadav A
AD - 1Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana
136119 India.
AU - Verma N
AD - 1Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana
136119 India.
AU - Gupta R
AD - 2Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana
136119 India.
AU - Aggarwal NK
AD - 3Department of Microbiology, Kurukshetra University, Kurukshetra, Haryana
136119 India.
SO - 3 Biotech. 2018, May; 8(5):232. []
AB - Chronic exposure of inorganic arsenic compounds is responsible for the
manifestation of various tumours as well as other diseases. The principal
mechanism behind arsenic toxicity is the induction of a strong oxidative
stress with production of free radicals in cells. The present study was
aimed to explore the shielding effect of anethole against oxidative damage
induced by arsenic in cultured human peripheral blood lymphocytes and the
effect of GSTO1 polymorphism. Sister chromatid exchange (SCE) frequency,
comet tail moment and lipid peroxidation levels were used as biomarkers to
assess the oxidative damage. Heparinised venous blood was collected from
healthy individuals and treated with sodium arsenite (50 &micro;M) in
the presence of anethole (25 and 50 &micro;M) for the analysis of
shielding effect of anethole. For the genotyping of GSTO1, PCR RFLP method
was adopted. A significant dose-dependent increase in the frequency of
SCEs, tail moment and lipid peroxidation levels, was observed when
lymphocytes were treated with sodium arsenite. Anethole in combination
with sodium arsenite has shown a dose-dependent significant decrease in
the frequency of SCEs, tail moment and lipid peroxidation levels. Genetic
polymorphism of GSTO1 was found to effect individual susceptibility
towards arsenic-mediated genotoxicity and was found insignificant when
antigenotoxic effect of anethole was considered. GSTO1 mutant genotypes
were found to have significant higher genotoxicity of sodium arsenite as
compared to wild-type genotype. The results of the present study suggest
ameliorative effects of anethole against arsenic-mediated genotoxic damage
in cultured human peripheral blood lymphocytes. A significant effect of
GSTO1 polymorphism was observed on genotoxicity of sodium arsenite.
COI - Compliance with ethical standardsThe authors declare that there is no
conflict of interest regarding the publication of the present work.
KW - Anethole
KW - Genotoxicity
KW - Oxidative stress
KW - Sodium arsenite
LA - eng
IS - 2190-572X (Print)
PT - Journal Article
TA - 3 Biotech
YR - 2018
DATE- 20180509
CITO- NLM
CS - Germany
FJT - 3 Biotech
EDAT- 20180430
STAT- PubMed-not-MEDLINE
CM - Cites: Mol Biotechnol. 2004 Mar;26(3):249-61 (medline /15004294)
CM - Cites: Chem Res Toxicol. 2001 Aug;14(8):1051-7 (medline /11511179)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 2004;84:1-477 (medline
/15645577)
CM - Cites: Am J Epidemiol. 2013 Sep 1;178(5):813-8 (medline /23764934)
CM - Cites: Pharmacogenetics. 2003 Mar;13(3):131-44 (medline /12618591)
CM - Cites: Cancer Lett. 2006 May 18;236(2):276-81 (medline /15992993)
CM - Cites: Chemosphere. 2012 Jul;88(4):432-8 (medline /22440634)
CM - Cites: J Appl Toxicol. 2011 Mar;31(2):95-107 (medline /21321970)
CM - Cites: Planta Med. 2008 Oct;74(13):1560-9 (medline /18612945)
CM - Cites: Curr Environ Health Rep. 2014 Jun 1;1(2):148-162 (medline
/25013752)
CM - Cites: Exp Cell Res. 1960 Sep;20:613-6 (medline /13772379)
CM - Cites: J Korean Med Sci. 2002 Jun;17(3):316-21 (medline /12068133)
CM - Cites: Exp Cell Res. 1988 Mar;175(1):184-91 (medline /3345800)
CM - Cites: Free Radic Biol Med. 2011 Jul 15;51(2):257-81 (medline /21554949)
CM - Cites: Toxicol Mech Methods. 2009 Jan;19(1):59-65 (medline /19778234)
CM - Cites: Toxicol Ind Health. 2016 Mar;32(3):410-21 (medline /24105067)
CM - Cites: Toxicol Appl Pharmacol. 1987 Oct;91(1):65-74 (medline /3672518)
CM - Cites: Environ Health Perspect. 2015 Jul;123(7):A169 (medline /26132290)
CM - Cites: Environ Health Perspect. 2013 Jul;121(7):832-8 (medline /23665672)
CM - Cites: J Biomed Sci. 2011 Jul 29;18:51 (medline /21798077)
CM - Cites: Food Chem Toxicol. 2001 May;39(5):493-8 (medline /11313116)
CM - Cites: Toxicol Lett. 2012 Apr 5;210(1):100-6 (medline /22306368)
CM - Cites: Int J Environ Res Public Health. 2013 Apr 12;10(4):1527-46 (medline
/23583964)
CM - Cites: Methods Enzymol. 1978;52:302-10 (medline /672633)
CM - Cites: Environ Health Perspect. 2008 Aug;116(8):1056-62 (medline
/18709164)
CM - Cites: PLoS Genet. 2012;8(2):e1002522 (medline /22383894)
CM - Cites: Molecules. 2011 Feb 01;16(2):1366-77 (medline /21285921)
CM - Cites: J Med Biochem. 2016 Sep;35(3):302-311 (medline /28356881)
CM - Cites: Anal Biochem. 1979 Jun;95(2):351-8 (medline /36810)
CM - Cites: Food Chem Toxicol. 1999 Jul;37(7):789-811 (medline /10496381)
CM - Cites: Mol Cell Biol. 1999 Jul;19(7):5166-9 (medline /10373565)
CM - Cites: Ecotoxicol Environ Saf. 2009 Feb;72(2):635-8 (medline /18499251)
CM - Cites: Nature. 1974 Sep 13;251(5471):156-8 (medline /4138930)
CM - Cites: Environ Res. 2011 Aug;111(6):804-10 (medline /21605854)
CM - Cites: Mutat Res. 2008 Jul 31;654(2):101-7 (medline /18602860)
DOCNO- medline/29725571
114 - TOXLINE
TI - Inorganic arsenic contents in ready-to-eat rice products and various
Korean rice determined by a highly sensitive gas chromatography-tandem
mass spectrometry.
AU - Jung MY
AD - Department of Food and Biotechnology, Graduate School, Woosuk University,
Samnye-eup, Wanju-gun, Jeonbuk Province 565-701, Republic of Korea; Agricultural
and Food Product Safety Analysis Center, Woosuk University, Republic of Korea.
Electronic address: munjung@woosuk.ac.kr.
AU - Kang JH
AD - Department of Food and Biotechnology, Graduate School, Woosuk University,
Samnye-eup, Wanju-gun, Jeonbuk Province 565-701, Republic of Korea.
AU - Jung HJ
AD - Department of Food Science and Biotechnology, College of Food Science, Woosuk
University, Samnye-eup, Wanju-gun, Jeonbuk Province 565-701, Republic of Korea.
AU - Ma SY
AD - Department of Food Science and Biotechnology, College of Food Science, Woosuk
University, Samnye-eup, Wanju-gun, Jeonbuk Province 565-701, Republic of Korea;
Agricultural and Food Product Safety Analysis Center, Woosuk University, Republic
of Korea.
SO - Food Chem. 2018, Feb 01; 240:1179-1183. [Food chemistry]
AB - Rice and rice products have been reported to contain high contents of
toxic inorganic arsenic (iAs). The inorganic arsenic contents in
microwavable ready-to-eat rice products (n=30) and different types of
Korean rice (n=102) were determined by a gas chromatography-tandem mass
spectrometry (GC-MS/MS). The method showed low limit of detection
(0.015pg), high intra- and inter-day repeatability ( < 7.3%, RSD), and
recovery rates (90-117%). The mean iAs content in the ready-to-eat rice
products was 59&mu;gkg-1 (dry weight basis). The mean iAs contents in
polished white, brown, black, and waxy rice were 65, 109, 91, and
66&mu;gkg-1, respectively. The percentages of ready-to-eat rice products,
white, brown, black, and waxy rice containing iAs over the maximum level
(100&mu;gkg-1) set by EU for the infant foods were 17, 4, 70, 36 and 0%,
respectively.
KW - Black rice
KW - British Anti-Lewisite
KW - Brown rice
KW - Derivatization
KW - Method validation
KW - Polished rice
KW - Safety
KW - Waxy rice
RN - N712M78A8G
LA - eng
IS - 0308-8146 (Print)
PT - Journal Article
TA - Food Chem
YR - 2018
DATE- 20171102
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Food chemistry
EDAT- 20170818
STAT- MEDLINE
DOCNO- medline/28946240
115 - TOXLINE
TI - Enhancing arsenic removal from arsenic-contaminated water by Echinodorus
cordifolius-endophytic Arthrobacter creatinolyticus interactions.
AU - Prum C
AD - School of Bioresources and Technology, King Mongkut's University of
Technology Thonburi, Bangkok 10150, Thailand.
AU - Dolphen R
AD - Pilot Plant Development and Training Institute, King Mongkut's University of
Technology Thonburi, Bangkok 10150, Thailand.
AU - Thiravetyan P
AD - School of Bioresources and Technology, King Mongkut's University of
Technology Thonburi, Bangkok 10150, Thailand. Electronic address:
paitip.thi@kmutt.ac.th.
SO - J Environ Manage. 2018, May 01; 213:11-19. [Journal of environmental
management]
AB - In this study, Echinodorus cordifolius was the best plant for arsenic
removal compared to Cyperus alternifolius, Acrostichum aureum and
Colocasia esculenta. Under arsenic stress, the combination of
E. cordifolius with microbes (Bacillus subtilis and Arthrobacter
creatinolyticus) was investigated. It was found that
A. creatinolyticus, a native microbe, can endure arsenic toxicity,
produce higher indole-3 acetic acid (IAA) and ammonium production better
than B. subtilis. Interestingly, E. cordifolius-endophytic
A. creatinolyticus interactions showed that dipping plant roots in
A. creatinolyticus suspension for 5&#8239;min had the highest arsenic
removal efficiency compared to dipping plant roots in
A. creatinolyticus suspension for 2&#8239;h and inoculating
A. creatinolyticus with E. cordifolius directly. Our findings
indicated that under this inoculation condition, the inoculum could
colonize from the roots to the shoots of the host tissues in order to
avoid arsenic toxicity and favored arsenic removal by the host through
plant growth-promoting traits, such as IAA production. Highest levels of
IAA were found in plant tissues and the plants exhibited higher root
elongation than other conditions. Moreover, low level of reactive oxygen
species (ROS) was related to low arsenic stress. In addition, dipping
E. cordifolius roots in A. creatinolyticus for 5&#8239;min was
applied in a constructed wetland, the result showed higher arsenic removal
than conventional method. Therefore, this knowledge can be applied at a
real site for improving plant tolerance stress, plant growth stimulation,
and enhancing arsenic remediation.
KW - Arsenic
KW - Arthrobacter creatinolyticus
KW - Constructed wetland
KW - Echinodorus cordifolius
KW - Reactive oxygen species (ROS)
KW - indole−3−acetic acid (IAA)
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180313
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180222
STAT- In-Process
DOCNO- medline/29477846
116 - TOXLINE
TI - N6-methyladenosine mediates the cellular proliferation and apoptosis via
microRNAs in arsenite-transformed cells.
AU - Gu S
AD - Department of Environmental and Occupational Health, West China School of
Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
AU - Sun D
AD - Department of Environmental and Occupational Health, West China School of
Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
AU - Dai H
AD - Department of Environmental and Occupational Health, West China School of
Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
AU - Zhang Z
AD - Department of Environmental and Occupational Health, West China School of
Public Health, Sichuan University, Chengdu, Sichuan, People's Republic of China.
Electronic address: zhangzunzhen@163.com.
SO - Toxicol Lett. 2018, Aug; 292:1-11. [Toxicology letters]
AB - N6-methyladenosine (m6A) modification is implicated to play an important
role in cellular biological processes, but its regulatory mechanisms in
arsenite-induced carcinogenesis are largely unknown. Here, human bronchial
epithelial (HBE) cells were chronically treated with 2.5&#8239;&mu;M
arsenite sodium (NaAsO2) for about 13 weeks and these cells were
identified with malignant phenotype which was demonstrated by increased
levels of cellular proliferation, percentages of plate colony formation
and soft agar clone formation, and high potential of resistance to
apoptotic induction. Our results firstly demonstrated that m6A
modification on RNA was significantly increased in arsenite-transformed
cells and this modification may be synergistically regulated by
methyltransferase-like 3 (METTL3), methyltransferase-like 14 (METTL14),
Wilms tumor 1-associated protein (WTAP) and Fat mass and
obesity-associated protein (FTO). In addition, knocking down of METTL3 in
arsenite-transformed cells can dramatically reverse the malignant
phenotype, which was manifested by lower percentages of clone and colony
formation as well as higher rates of apoptotic induction. Given the
critical roles of miRNAs in cellular proliferation and apoptosis, miRNAs
regulated by m6A in arsenite-transformed cells were analyzed by Venn
diagram and KEGG pathway in this study. The results showed that these
m6A-mediated miRNAs can regulate pathways which are closely associated
with cellular proliferation and apoptosis, implicating that these miRNAs
may be the critical bridge by which m6A mediates dysregulation of cell
survival and apoptosis in arsenite-transformed cells. Taken together, our
results firstly demonstrated the significant role of m6A in the prevention
of tumor occurrence and progression induced by arsenite.
KW - Apoptosis
KW - Arsenite
KW - Cellular proliferation
KW - MicroRNA
KW - N(6)-methyladenosine
RN - 1867-73-8
RN - 48OVY2OC72
RN - EC 1.14.11.33
RN - EC 1.14.11.33
RN - EC 2.1.1.-
RN - EC 2.1.1.-
RN - EC 2.1.1.62
RN - K72T3FS567
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20180612
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Toxicology letters
EDAT- 20180420
STAT- MEDLINE
DOCNO- medline/29680375

117 - TOXLINE
TI - The possible neuroprotective effect of ellagic acid on sodium
arsenate-induced neurotoxicity in rats.
AU - Goudarzi M
AD - Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical
Sciences, Ahvaz, Iran; Student Research Committee, Ahvaz Jundishapur University of
Medical Sciences, Ahvaz, Iran.
AU - Amiri S
AD - Department of Pharmacology, School of Medicine, Iran University of Medical
Sciences, Tehran, Iran.
AU - Nesari A
AD - Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences,
Ahvaz, Iran.
AU - Hosseinzadeh A
AD - Air Pollution Research Center, Iran University of Medical Sciences, Tehran,
Iran.
AU - Mansouri E
AD - Cellular and Molecular Research Center, Department of Anatomical Sciences,
Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AU - Mehrzadi S
AD - Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Electronic address: mehrzadi.s@iums.ac.ir.
SO - Life Sci. 2018, Apr 01; 198:38-45. [Life sciences]
AB - OBJECTIVE: Arsenic is a well-known environmental contaminant, causing
toxicity in different organs. The aim of this study was to investigate the
possible neuroprotective effect of ellagic acid (EA) on arsenic-induced
neurotoxicity in rats.
AB - DESIGN: Animals were divided into five groups. The first group received
normal saline (2&#8239;mL/kg) for 21&#8239;days as control group. Group 2
was orally treated with sodium arsenite (SA, 10&#8239;mg/kg) for
21&#8239;days. Groups 3 and 4 were orally treated with SA (10&#8239;mg/kg)
for 7&#8239;days prior to EA (10 and 30&#8239;mg/kg respectively)
treatment and continued up to 21&#8239;days simultaneously with SA
administration. Group 5 was orally treated with EA (30&#8239;mg/kg) for
14&#8239;days. Passive avoidance test and rotarod test were done to
evaluate the behavioral changes following SA and/or EA treatment.
Different biochemical, histological and molecular biomarkers were assessed
in the brain tissue.
AB - RESULTS: Our data showed that SA significantly elevated brain tissue
arsenic levels and malondialdehyde, nitric oxide, protein carbonylation,
tumor necrosis factor-alpha, and interlukein-1&beta; production. A
decrease in the total antioxidant capacity, reduced glutathione content
and glutathione peroxidase activity occurred in the brain of rats exposed
to SA. SA-treated rats showed a significant impairment in
long-term-memory, motor coordination and equilibrium. These results were
supported by histopathological observations of the brain. Results revealed
that administration of EA (30&#8239;mg/kg) reversed all neural markers
alternation and ameliorated behavioral and histopathological changes
induced by SA.
AB - CONCLUSION: EA can effectively protect brain tissue against SA-induced
neurotoxicity via its antioxidant and anti-inflammatory effects.
KW - Ellagic acid
KW - Neuroprotection
KW - Oxidative stress
KW - Rat
KW - Sodium arsenite
RN - 19YRN3ZS9P
RN - 31C4KY9ESH
RN - 7XO134LHLN
RN - EC 1.11.1.9
LA - eng
IS - 1879-0631 (Electronic)
PT - Journal Article
TA - Life Sci
YR - 2018
DATE- 20180409
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Life sciences
EDAT- 20180215
STAT- MEDLINE
DOCNO- medline/29455002

118 - TOXLINE
TI - Speciation, mobilization, and bioaccessibility of arsenic in geogenic soil
profile from Hong Kong.
AU - Cui JL
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong.
AU - Zhao YP
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong.
AU - Li JS
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong.
AU - Beiyuan JZ
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong.
AU - Tsang DCW
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong.
AU - Poon CS
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong.
AU - Chan TS
AD - National Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu
Science Park, Hsinchu 30076, Taiwan.
AU - Wang WX
AD - Division of Life Science, The Hong Kong University of Science and Technology
(HKUST), Clearwater Bay, Kowloon, Hong Kong.
AU - Li XD
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong. Electronic address: cexdli@polyu.edu.hk.
SO - Environ Pollut. 2018, Jan; 232:375-384. [Environmental pollution (Barking,
Essex : 1987)]
AB - The behaviour of arsenic (As) from geogenic soil exposed to aerobic
conditions is critical to predict the impact of As on the environment,
which processes remain unresolved. The current study examined the depth
profile of As in geologically derived subsoil cores from Hong Kong and
investigated the mobilization, plant availability, and bioaccessibility of
As in As-contaminated soil at different depths (0-45.8 m). Results
indicated significant heterogeneity, with high levels of As in three
layers of soil reaching up to 505 mg/kg at a depth of 5 m,
404 mg/kg at a depth of 15 m, and 1510 mg/kg at a depth of
27-32 m. Arsenic in porewater samples was < 11.5 &mu;g/L in
the study site. X-ray absorption spectroscopy (XAS) indicated that main As
species in soil was arsenate (As(V)), as adsorbed fraction to Fe oxides
(41-69% on goethite and 0-8% on ferrihydrite) or the mineral form
scorodite (30-57%). Sequential extraction procedure demonstrated that
0.5 &plusmn; 0.4% of As was exchangeable. Aerobic incubation
experiments exhibited that a very small amount (0.14-0.48 mg/kg) of
As was desorbed from the soil because of the stable As(V) complex
structure on abundant Fe oxides (mainly goethite), where indigenous
microbes partly (59 &plusmn; 18%) contributed to the release of
As comparing with the sterilized control. Furthermore, no As toxicity in
the soil was observed with the growth of ryegrass. The bioaccessibility of
As was < 27% in the surface soil using simplified bioaccessibility
extraction test. Our systematic evaluation indicated that As in the
geogenic soil profile from Hong Kong is relatively stable exposing to
aerobic environment. Nevertheless, children and workers should avoid
incidental contact with excavated soil, because high concentration of As
was present in the digestive solution ( < 0.1-268 &mu;g/L).
KW - Aerobic incubation
KW - Arsenic biogeochemistry
KW - Bioaccessibility
KW - Fe oxide
KW - Mobility
RN - 1310-14-1
RN - 87PZU03K0K
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180122
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20170928
STAT- MEDLINE
DOCNO- medline/28966030

119 - TOXLINE
TI - miR-145 via targeting ERCC2 is involved in arsenite-induced DNA damage in
human hepatic cells.
AU - Wei S
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, Department of Toxicology, School of Public Health, Guizhou
Medical University, Guiyang 550025, Guizhou, People's Republic of China.
AU - Xue J
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, People's
Republic of China.
AU - Sun B
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, Department of Toxicology, School of Public Health, Guizhou
Medical University, Guiyang 550025, Guizhou, People's Republic of China.
AU - Zou Z
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, Department of Toxicology, School of Public Health, Guizhou
Medical University, Guiyang 550025, Guizhou, People's Republic of China.
AU - Chen C
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, People's
Republic of China.
AU - Liu Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing 211166, Jiangsu, People's
Republic of China. Electronic address: drqzliu@hotmail.com.
AU - Zhang A
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, Department of Toxicology, School of Public Health, Guizhou
Medical University, Guiyang 550025, Guizhou, People's Republic of China. Electronic
address: aihuagzykd@163.com.
SO - Toxicol Lett. 2018, Apr 26. [Toxicology letters]
AB - Arsenic, an established human carcinogen, causes genetic toxicity.
However, the molecular mechanisms involved remain unknown. MicroRNAs
(miRNAs) are regulators that participate in fundamental cellular
processes. In the present investigation, we selected, as research
subjects, patients with arsenic poisoning caused by burning of coal in
Guizhou Province, China. For these patients, the plasma levels of miR-145
were up-regulated. In L-02 cells, arsenite, an active form of arsenic,
induced up-regulation of miR-145 and down-regulation of ERCC1 and ERCC2,
and caused DNA damage. For L-02 cells, transfection with an miR-145
inhibitor prevented arsenite-induced DNA damage and decreased ERCC2
levels. Luciferase reporter assays showed that miR-145 regulated ERCC2
expression by targeting the 3'-UTR of ERCC2, but not that for ERCC1. The
present results demonstrate that arsenite induces the over-expression of
miR-145 and inhibits DNA repair via targeting ERCC2, thus promoting DNA
damage. The information provides a new mechanism for arsenic-induced liver
injury.
KW - DNA repair
KW - ERCC2
KW - arsenicosis
KW - liver damage
KW - miR-145
KW - microRNAs
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20180429
CI - Copyright &copy; 2018. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
FJT - Toxicology letters
EDAT- 20180426
STAT- Publisher
DOCNO- medline/29705342

120 - TOXLINE
TI - Developmental Neurotoxicity of Arsenic: Involvement of Oxidative Stress
and Mitochondrial Functions.
AU - Chandravanshi LP
AD - Developmental Toxicology Division, CSIR-Indian Institute of Toxicology
Research, Post Box No. 80, MG Marg, Lucknow, 226 001, India.
chandravanshi04@gmail.com.
AU - Gupta R
AD - Developmental Toxicology Division, CSIR-Indian Institute of Toxicology
Research, Post Box No. 80, MG Marg, Lucknow, 226 001, India.
AU - Shukla RK
AD - Department of Biochemistry, All India Institute of Medical Sciences, Bhopal,
India.
SO - Biol Trace Elem Res. 2018, Mar 03. [Biological trace element research]
AB - Over the last decade, there has been an increased concern about the health
risks from exposure to arsenic at low doses, because of their neurotoxic
effects on the developing brain. The exact mechanism underlying
arsenic-induced neurotoxicity during sensitive periods of brain
development remains unclear, although enhanced oxidative stresses, leading
to mitochondrial dysfunctions might be involved. Here, we highlight the
generation of reactive oxygen species (ROS) and oxidative stress which
leads to mitochondrial dysfunctions and apoptosis in arsenic-induced
developmental neurotoxicity. Here, the administration of sodium arsenite
at doses of 2 or 4 mg/kg body weight in female rats from gestational
to lactational (GD6-PD21) resulted to increased ROS, led to oxidative
stress, and increased the apoptosis in the frontal cortex, hippocampus,
and corpus striatum of developing rats on PD22, compared to controls.
Enhanced levels of ROS were associated with decreased mitochondrial
membrane potential and the activity of mitochondrial complexes, and
hampered antioxidant levels. Further, neuronal apoptosis, as measured by
changes in the expression of pro-apoptotic (Bax, Caspase-3),
anti-apoptotic (Bcl2), and stress marker proteins (p-p38, pJNK) in
arsenic-exposed rats, was discussed. The severities of changes were found
to more persist in the corpus striatum than in other brain regions of
arsenic-exposed rats even after the withdrawal of exposure on PD45 as
compared to controls. Therefore, our results indicate that perinatal
arsenic exposure leads to abrupt changes in ROS, oxidative stress, and
mitochondrial functions and that apoptotic factor in different brain
regions of rats might contribute to this arsenic-induced developmental
neurotoxicity.
KW - Apoptosis
KW - Arsenic
KW - Developmental neurotoxicity
KW - Mitochondria
KW - Oxidative stress
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180304
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180303
STAT- Publisher
DOCNO- medline/29502250

121 - TOXLINE
TI - Low arsenic concentrations impair memory in rat offpring exposed during
pregnancy and lactation: Role of &alpha;7 nicotinic receptor, glutamate
and oxidative stress.
AU - M�naco NM
AD - Laboratorio de Toxicolog�a, Instituto de Investigaciones Biol�gicas y
Biom�dicas del Sur (INBIOSUR), Departamento de Biolog�a, Bioqu�mica y Farmacia,
Universidad Nacional del Sur, Consejo Nacional de Investigaciones Cient�ficas y
T�cnicas (CONICET), Depto. de Biolog�a, Bioqu�mica y Farmacia, San Juan 670, 8000
Bah�a Blanca, Argentina.
AU - Bartos M
AD - Laboratorio de Toxicolog�a, Instituto de Investigaciones Biol�gicas y
Biom�dicas del Sur (INBIOSUR), Departamento de Biolog�a, Bioqu�mica y Farmacia,
Universidad Nacional del Sur, Consejo Nacional de Investigaciones Cient�ficas y
T�cnicas (CONICET), Depto. de Biolog�a, Bioqu�mica y Farmacia, San Juan 670, 8000
Bah�a Blanca, Argentina.
AU - Dominguez S
AD - Laboratorio de Toxicolog�a, Instituto de Investigaciones Biol�gicas y
Biom�dicas del Sur (INBIOSUR), Departamento de Biolog�a, Bioqu�mica y Farmacia,
Universidad Nacional del Sur, Consejo Nacional de Investigaciones Cient�ficas y
T�cnicas (CONICET), Depto. de Biolog�a, Bioqu�mica y Farmacia, San Juan 670, 8000
Bah�a Blanca, Argentina.
AU - Gallegos C
AD - Laboratorio de Toxicolog�a, Instituto de Investigaciones Biol�gicas y
Biom�dicas del Sur (INBIOSUR), Departamento de Biolog�a, Bioqu�mica y Farmacia,
Universidad Nacional del Sur, Consejo Nacional de Investigaciones Cient�ficas y
T�cnicas (CONICET), Depto. de Biolog�a, Bioqu�mica y Farmacia, San Juan 670, 8000
Bah�a Blanca, Argentina.
AU - Bras C
AD - Laboratorio de Toxicolog�a, Instituto de Investigaciones Biol�gicas y
Biom�dicas del Sur (INBIOSUR), Departamento de Biolog�a, Bioqu�mica y Farmacia,
Universidad Nacional del Sur, Consejo Nacional de Investigaciones Cient�ficas y
T�cnicas (CONICET), Depto. de Biolog�a, Bioqu�mica y Farmacia, San Juan 670, 8000
Bah�a Blanca, Argentina.
AU - Esandi MDC
AD - Instituto de Investigaciones Bioqu�micas de Bah�a Blanca (INIBIBB),
Departamento de Biolog�a, Bioqu�mica y Farmacia, Universidad Nacional del Sur,
Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET), Depto. de
Biolog�a, Bioqu�mica y Farmacia, Camino La Carrindanga km7, Bah�a Blanca,
Argentina.
AU - Bouzat C
AD - Instituto de Investigaciones Bioqu�micas de Bah�a Blanca (INIBIBB),
Departamento de Biolog�a, Bioqu�mica y Farmacia, Universidad Nacional del Sur,
Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET), Depto. de
Biolog�a, Bioqu�mica y Farmacia, Camino La Carrindanga km7, Bah�a Blanca,
Argentina.
AU - Giannuzzi L
AD - Centro de Investigaci�n y Desarrollo en Criotecnolog�a de Alimentos (CIDCA),
CCT-La Plata, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900
La Plata, Argentina.
AU - Minetti A
AD - Laboratorio de Toxicolog�a, Instituto de Investigaciones Biol�gicas y
Biom�dicas del Sur (INBIOSUR), Departamento de Biolog�a, Bioqu�mica y Farmacia,
Universidad Nacional del Sur, Consejo Nacional de Investigaciones Cient�ficas y
T�cnicas (CONICET), Depto. de Biolog�a, Bioqu�mica y Farmacia, San Juan 670, 8000
Bah�a Blanca, Argentina.
AU - Gumilar F
AD - Laboratorio de Toxicolog�a, Instituto de Investigaciones Biol�gicas y
Biom�dicas del Sur (INBIOSUR), Departamento de Biolog�a, Bioqu�mica y Farmacia,
Universidad Nacional del Sur, Consejo Nacional de Investigaciones Cient�ficas y
T�cnicas (CONICET), Depto. de Biolog�a, Bioqu�mica y Farmacia, San Juan 670, 8000
Bah�a Blanca, Argentina. Electronic address: fgumilar@criba.edu.ar.
SO - Neurotoxicology. 2018, Apr 17; 67:37-45. [Neurotoxicology]
AB - Inorganic arsenic (iAs) is an important natural pollutant. Millions of
individuals worldwide drink water with high levels of iAs. Arsenic
exposure has been associated to cognitive deficits. However, the
underlying mechanisms remain unknown. In the present work we investigated
in female adult offspring the effect of the exposure to low arsenite
sodium levels through drinking water during pregnancy and lactation on
short- and long-term memory. We also considered a possible underlying
neurotoxic mechanism. Pregnant rats were exposed during pregnancy and
lactation to environmentally relevant iAs concentrations (0.05 and
0.10&#8239;mg/L). In 90-day-old female offspring, short-term memory (STM)
and long-term memory (LTM) were evaluated using a step-down inhibitory
avoidance task. In addition, we evaluated the &alpha;7 nicotinic receptor
(&alpha;7-nAChR) expression, the transaminases and the oxidative stress
levels in hippocampus. The results showed that the exposure to
0.10&#8239;mg/L iAs in this critical period produced a significant
impairment in the LTM retention. This behavioral alteration might be
associated with several events that occur in the hippocampus: decrease in
&alpha;7-nAChR expression, an increase of glutamate levels that may
produce excitotoxicity, and a decrease in the antioxidant enzyme catalase
(CAT) activity.
KW - Arsenic
KW - Female rats
KW - Glutamate
KW - Oxidative stress
KW - α7-nicotinic receptor
LA - eng
IS - 1872-9711 (Electronic)
PT - Journal Article
TA - Neurotoxicology
YR - 2018
DATE- 20180616
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Neurotoxicology
EDAT- 20180417
STAT- Publisher
DOCNO- medline/29678590

122 - TOXLINE
TI - Mussels and clams from the italian fish market. is there a human
exposition risk to metals and arsenic?
AU - Chiesa LM
AD - Department of Health, Animal Science and Food Safety, University of Milan,
Via Celoria, 10, 20133 Milan, Italy.
AU - Ceriani F
AD - Department of Health, Animal Science and Food Safety, University of Milan,
Via Celoria, 10, 20133 Milan, Italy.
AU - Caligara M
AD - Department of Biomedical Sciences for Health, University of Milan, Via L.
Mangiagalli, 37, 20133 Milan, Italy.
AU - Di Candia D
AD - Department of Biomedical, Surgical and Dental Sciences, University of Milan,
Via L. Mangiagalli, 37, 20133 Milan, Italy.
AU - Malandra R
AD - ATS Milano-Citt� metropolitana, Veterinary Unit, Via Celoria 10, 20133 Milan,
Italy.
AU - Panseri S
AD - Department of Health, Animal Science and Food Safety, University of Milan,
Via Celoria, 10, 20133 Milan, Italy. Electronic address: sara.panseri@unimi.it.
AU - Arioli F
AD - Department of Health, Animal Science and Food Safety, University of Milan,
Via Celoria, 10, 20133 Milan, Italy.
SO - Chemosphere. 2018, Mar; 194:644-649. [Chemosphere]
AB - Seafood is associated with many beneficial effects on human health.
However, the overall level of contaminants in biota has increased over the
last two centuries and seafood is one of the source of oral exposition to
contaminants. Therefore, this work aimed to evaluate cadmium, lead,
mercury, arsenic, chromium and nickel presence in mussels and clams, from
the Italian market, and the associated risk. The samples were from five
different FAO areas. Analyses were carried out using inductively-coupled
plasms-mass spectrometry. The sample concentrations were below the maximum
levels stated by Commission Regulation (EC) 1881/2006, except one mussel
sample, which was non-compliant for cadmium
(2.13 &plusmn; 0.20 mg kg-1). For arsenic, nickel and
chromium, maximum levels are not stated by the European Union. In this
study, arsenic ranged from 1.29 to 13.35 mg kg-1 and nickel
ranged from < LOQ-3.98 mg kg-1, except one sample, whose
nickel concentration was 21.70 mg kg-1. Chromium was found only
in 15 samples, with a maximum concentration of
2.81 &plusmn; 0.27 mg kg-1, in one clam sample. Our
results indicate that the average Italian consumption of molluscs, does
not pose a risk for consumers, except nickel, which can cause allergic
dermatitis in nickel-sensitive individuals. However a particular concern
is caused by the exposition to As of the 95th percentile consumers: the
Hazard Index for skin lesions, was > 1, and BMDL10 for lung bladder and
skin cancer in all mussel samples was overcome, in the 100% and 25% of
mussel and clam samples, respectively.
KW - Arsenic
KW - Clams
KW - Health risk
KW - ICP-MS
KW - Metals
KW - Mussels
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180402
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171222
STAT- MEDLINE
DOCNO- medline/29241139

123 - TOXLINE
TI - Effects of elevated sulfate concentration on the mobility of arsenic in
the sediment-water interface.
AU - Li S
AD - School of Ecology and Environmental Science &amp; Yunnan Key Laboratory for
Plateau Mountain Ecology and Restoration of Degraded Environments, Yunnan
University, Kunming 650091, China; Institute of Environment Sciences, Department of
Biology Science, University of Quebec at Montreal, Montreal, Canada C3H 3P8.
AU - Yang C
AD - School of Ecology and Environmental Science &amp; Yunnan Key Laboratory for
Plateau Mountain Ecology and Restoration of Degraded Environments, Yunnan
University, Kunming 650091, China. Electronic address: YANGCL227@163.com.
AU - Peng C
AD - Institute of Environment Sciences, Department of Biology Science, University
of Quebec at Montreal, Montreal, Canada C3H 3P8.
AU - Li H
AD - Institute of Environment Sciences, Department of Biology Science, University
of Quebec at Montreal, Montreal, Canada C3H 3P8; Faculty of Land Resource
Engineering, Kunming University of Science and Technology, Kunming 650093, China.
AU - Liu B
AD - School of Ecology and Environmental Science &amp; Yunnan Key Laboratory for
Plateau Mountain Ecology and Restoration of Degraded Environments, Yunnan
University, Kunming 650091, China.
AU - Chen C
AD - Institute of International rivers and eco-security, Yunnan University,
Kunming 650091, China.
AU - Chen B
AD - Institute of International rivers and eco-security, Yunnan University,
Kunming 650091, China.
AU - Bai J
AD - Institute of International rivers and eco-security, Yunnan University,
Kunming 650091, China.
AU - Lin C
AD - Institute of International rivers and eco-security, Yunnan University,
Kunming 650091, China.
SO - Ecotoxicol Environ Saf. 2018, Jun 15; 154:311-320. [Ecotoxicology and
environmental safety]
AB - The adsorption/desorption of arsenic (As) at the sediment-water interface
in lakes is the key to understanding whether As can enter the ecosystem
and participate in material circulation. In this study, the concentrations
of As(III), total arsenic [As(T)], sulfide, iron (Fe), and dissolved
organic carbon (DOC) in overlying water were observed after the initial
sulfate (SO42-) concentrations were increased by four gradients in the
presence and absence of microbial systems. The results indicate that
increased SO42- concentrations in overlying water triggered As desorption
from sediments. Approximately 10% of the desorbed As was desorbed directly
as arsenite or arsenate by competitive adsorption sites on the iron salt
surface; 21% was due to the reduction of iron (hydr)oxides; and 69% was
due to microbial activity, as compared with a system with no microbial
activity. The intensity of microbial activity was controlled by the SO42-
and DOC concentrations in the overlying water. In anaerobic systems, which
had SO42- and DOC concentrations higher than 47 and 7&#8239;mg/L,
respectively, microbial activity was promoted by SO42- and DOC; As(III)
was desorbed under these indoor simulation conditions. When either the
SO42- or DOC concentration was lower than its respective threshold of 47
or 7&#8239;mg/L, or when either of these indices was below its
concentration limit, it was difficult for microorganisms to use SO42- and
DOC to enhance their own activities. Therefore, conditions were
insufficient for As desorption. The migration of As in lake sediments was
dominated by microbial activity, which was co-limited by SO42- and DOC.
The concentrations of SO42- and DOC in the overlying water are thus
important for the prevention and control of As pollution in lakes. We
recommend controlling SO42- and DOC concentrations as a method for
controlling As inner-source pollution in lake water.
KW - Arsenic contamination
KW - Lake sediment
KW - Sediment–water interface
KW - Water pollution
RN - E1UOL152H7
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180614
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
STAT- MEDLINE
DOCNO- medline/29482126

124 - TOXLINE
TI - Effect of subchronic exposure to inorganic arsenic on the structure and
function of the intestinal epithelium.
AU - Chiocchetti GM
AD - Instituto de Agroqu�mica y Tecnolog�a de Alimentos (IATA-CSIC), Calle Agust�n
Escardino 7, 46980, Paterna, Valencia, Spain.
AU - V�lez D
AD - Instituto de Agroqu�mica y Tecnolog�a de Alimentos (IATA-CSIC), Calle Agust�n
Escardino 7, 46980, Paterna, Valencia, Spain.
AU - Devesa V
AD - Instituto de Agroqu�mica y Tecnolog�a de Alimentos (IATA-CSIC), Calle Agust�n
Escardino 7, 46980, Paterna, Valencia, Spain. Electronic address:
vdevesa@iata.csic.es.
SO - Toxicol Lett. 2018, Apr; 286:80-88. [Toxicology letters]
AB - Inorganic arsenic (As), the most toxic form of As found in water and food,
is considered a human carcinogen. Numerous studies show its systemic
toxicity, describing pathologies associated with chronic exposure. The
main pathway of exposure to inorganic As is oral, but many of the events
that occur during its passage through the gastrointestinal tract are
unknown. This study evaluates the effect of subchronic exposure to
inorganic As [As(III): 0.025-0.1&#8239;mg/L; As(V): 0.25-1&#8239;mg/L, up
to 21&#8239;days] on the intestinal epithelium, using Caco-2 cells as in
vitro model. Inorganic As produces a pro-inflammatory response throughout
the exposure time, with an increase in IL-8 release (up to 488%). It also
causes changes in the program of cell proliferation and differentiation,
which leads to impairment of the cell repair process. In addition,
subchronic exposure affects the epithelial structure, causing loss of
microvilli, fundamental structures in the processes of intestinal
absorption and digestion. Moreover, the exposure affects the epithelial
barrier function, evidenced by an increase of Lucifer Yellow transport
(103-199%). Therefore, it can be concluded that subchronic exposure to
inorganic As can alter intestinal homeostasis, affecting the mucosal
layer, which performs the most important functions of the intestinal wall.
KW - Caco-2 cells
KW - Differentiation
KW - Inflammation
KW - Inorganic arsenic
KW - Intestinal epithelium
KW - Permeability
KW - Proliferation
KW - Subchronic exposure
KW - Wound healing
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20180213
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Toxicology letters
EDAT- 20180131
STAT- In-Process
DOCNO- medline/29355690

125 - TOXLINE
TI - Association of H3K79 monomethylation (an epigenetic signature) with
arsenic-induced skin lesions.
AU - Bhattacharjee P
AD - Department of Zoology and Department of Environmental Science, University of
Calcutta, Kolkata 700019, India.
AU - Paul S
AD - Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology,
Kolkata 700032, India.
AU - Bhattacharjee S
AD - Health-Management in Occupational Health, Siemens, India.
AU - Giri AK
AD - Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology,
Kolkata 700032, India.
AU - Bhattacharjee P
AD - Department of Environmental Science, University of Calcutta, Kolkata 700019,
India. Electronic address: 777.pritha@gmail.com.
SO - Mutat Res. 2018, Jan; 807:1-9. [Mutation research]
AB - Arsenic, a non mutagenic carcinogen, poses a profound health risk upon
prolonged exposure. The objective of the study was to analyze the
post-translational modifications of the major histone H3 and the
associated molecular crosstalk to identify the epigenetic signature of
arsenic susceptibility. Herein, we identified significant upregulation of
H3K79me1, in individuals with arsenic-induced skin lesion (WSL), and
H3K79me1 was found to be regulated by the upstream methyltransferase
DOT1L. Moreover, the downstream target molecule 53BP1, a tumor suppressor
protein that has a docking preference for H3K79me1 at a site of a
double-strand break (DSB), was downregulated, indicating greater DNA
damage in the WSL group. Western blot data confirmed higher levels of
&gamma;H2AX, a known marker of DSBs, in group WSL. In vitro dose-response
analysis also confirmed the association of the H3K79me1 signature with
arsenic toxicity. Taken together, our findings revealed that H3K79me1 and
DOT1L could be a novel epigenetic signature of the arsenic-exposed WSL
group.
KW - Arsenic-induced skin lesion
KW - DNA damage
KW - DOT1L
KW - Epigenetic signature
KW - H3K79me1
LA - eng
IS - 1873-135X (Electronic)
PT - Journal Article
TA - Mutat Res
YR - 2018
DATE- 20180206
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Mutation research
EDAT- 20171114
STAT- In-Data-Review
DOCNO- medline/29161537

126 - TOXLINE
TI - Proteomics and genetic analyses reveal the effects of arsenite oxidation
on metabolic pathways and the roles of AioR in Agrobacterium tumefaciens
GW4.
AU - Shi K
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China.
AU - Wang Q
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China.
AU - Fan X
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China.
AU - Wang G
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, PR China.
Electronic address: gejiao@mail.hzau.edu.cn.
SO - Environ Pollut. 2018, Apr; 235:700-709. [Environmental pollution (Barking,
Essex : 1987)]
AB - A heterotrophic arsenite [As(III)]-oxidizing bacterium Agrobacterium
tumefaciens GW4 isolated from As(III)-rich groundwater sediment showed
high As(III) resistance and could oxidize As(III) to As(V). The As(III)
oxidation could generate energy and enhance growth, and AioR was the
regulator for As(III) oxidase. To determine the related metabolic pathways
mediated by As(III) oxidation and whether AioR regulated other cellular
responses to As(III), isobaric tags for relative and absolute quantitation
(iTRAQ) was performed in four treatments, GW4 (+AsIII)/GW4 (-AsIII),
GW4-&Delta;aioR (+AsIII)/GW4-&Delta;aioR (-AsIII), GW4-&Delta;aioR
(-AsIII)/GW4 (-AsIII) and GW4-&Delta;aioR (+AsIII)/GW4 (+AsIII). A total
of 41, 71, 82 and 168 differentially expressed proteins were identified,
respectively. Using electrophoretic mobility shift assay (EMSA) and
qRT-PCR, 12 genes/operons were found to interact with AioR. These results
indicate that As(III) oxidation alters several cellular processes related
to arsenite, such as As resistance (ars operon), phosphate (Pi) metabolism
(pst/pho system), TCA cycle, cell wall/membrane, amino acid metabolism and
motility/chemotaxis. In the wild type with As(III), TCA cycle flow is
perturbed, and As(III) oxidation and fermentation are the main energy
resources. However, when strain GW4-&Delta;aioR lost the ability of
As(III) oxidation, the TCA cycle is the main way to generate energy. A
regulatory cellular network controlled by AioR is constructed and shows
that AioR is the main regulator for As(III) oxidation, besides, several
other functions related to As(III) are regulated by AioR in parallel.
KW - Arsenite oxidation regulator
KW - Arsenite resistance
KW - Comparative proteomics
KW - Energy
KW - Phosphate
RN - N5509X556J
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180112
STAT- MEDLINE
DOCNO- medline/29339339

127 - TOXLINE
TI - Antimony and arsenic partitioning during Fe2+-induced transformation of
jarosite under acidic conditions.
AU - Karimian N
AD - Southern Cross GeoScience, Southern Cross University, Lismore, NSW 2480,
Australia. Electronic address: niloofar.karimian@scu.edu.au.
AU - Johnston SG
AD - Southern Cross GeoScience, Southern Cross University, Lismore, NSW 2480,
Australia.
AU - Burton ED
AD - Southern Cross GeoScience, Southern Cross University, Lismore, NSW 2480,
Australia.
SO - Chemosphere. 2018, Mar; 195:515-523. [Chemosphere]
AB - Jarosite [KFe3(SO4)2(OH)6] is considered a potent scavenger for arsenic
(As) and antimony (Sb) under oxidizing conditions. Fluctuations in water
levels in re-flooded acid sulfate soils (ASS) can lead to high Fe2+(aq)
concentrations (&sim;10-20&#8239;mM) in the soil solution under acidic to
circumneutral pH conditions. This may create favorable conditions for the
Fe2+-induced transformation of jarosite. In this study, synthetic arsenate
[As(V)]/antimonate [Sb(V)]-bearing jarosite was subjected to Fe2+(aq)
(20&#8239;mM) at pH 4.0 and 5.5 for 24&#8239;h to simulate the pH and
Fe2+(aq) conditions of re-flooded freshwater ASS/acid mine drainage
(AMD)-affected environments at early and mid-stages of remediation,
respectively. The addition of Fe2+ at pH 5.5 resulted in the formation of
a metastable green rust sulfate (GR- SO4) phase within &sim;60&#8239;min,
which was replaced by goethite within 24&#8239;h. In contrast, at pH 4.0,
jarosite underwent no significant mineralogical transformation. Although
the addition of Fe2+(aq) induced the dissolution/transformation of
jarosite at pH 5.5 and increased the mobility of Sb during the initial
stages of the experiment (Sb(aq) = &sim;0.05&#8239;&mu;mol&#8239;L-1),
formation of metastable green rust (GR-SO4) and subsequent transformation
to goethite effectively sequestered dissolved Sb. Aqueous concentrations
of As remained negligible in both pH treatments, with As being mostly
repartitioned to the labile (&sim;10%) and poorly crystalline
Fe(III)-associated phases (&sim;10-30%). The results imply that, under
moderately acidic conditions (i.e. pH 5.5), reaction of Fe2+(aq) with
jarosite can drive the dissolution of jarosite and increase Sb mobility
prior to the formation of GR-SO4 and goethite. In addition, repartitioning
of As to the labile fractions at pH 5.5 may enhance the risk of its
mobilisation during future mineral transformation processes in Fe2+-rich
systems.
KW - Antimony
KW - Arsenic
KW - Fe(2+)
KW - Green rust
KW - Jarosite
KW - pH
RN - 1310-14-1
RN - 9IT35J3UV3
RN - N712M78A8G
RN - N7CIZ75ZPN
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180606
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171227
STAT- MEDLINE
DOCNO- medline/29277031

128 - TOXLINE
TI - Inorganic arsenic causes apoptosis cell death and immunotoxicity on
European sea bass (Dicentrarchus labrax).
AU - Cordero H
AD - Fish Innate Immune System Group, Department of Cell Biology and Histology,
Faculty of Biology, Regional Campus of International Excellence "Campus Mare
Nostrum", University of Murcia, 30100 Murcia, Spain.
AU - Morcillo P
AD - Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300
Morris Park Avenue, Bronx, 10461, NY, USA.
AU - Mart�nez S
AD - Department of Agricultural Chemistry, Geology and Pedology, Faculty of
Chemistry, Campus Regional de Excelencia Internacional "Campus Mare Nostrum",
University of Murcia, 30100 Murcia, Spain.
AU - Meseguer J
AD - Fish Innate Immune System Group, Department of Cell Biology and Histology,
Faculty of Biology, Regional Campus of International Excellence "Campus Mare
Nostrum", University of Murcia, 30100 Murcia, Spain.
AU - P�rez-Sirvent C
AD - Department of Agricultural Chemistry, Geology and Pedology, Faculty of
Chemistry, Campus Regional de Excelencia Internacional "Campus Mare Nostrum",
University of Murcia, 30100 Murcia, Spain.
AU - Chaves-Pozo E
AD - Centro Oceanogr�fico de Murcia, Instituto Espa�ol de Oceanograf�a (IEO),
Carretera de la Azoh�a s/n., 30860 Puerto de Mazarr�n, Murcia, Spain.
AU - Mart�nez-Sanchez MJ
AD - Department of Agricultural Chemistry, Geology and Pedology, Faculty of
Chemistry, Campus Regional de Excelencia Internacional "Campus Mare Nostrum",
University of Murcia, 30100 Murcia, Spain.
AU - Cuesta A
AD - Fish Innate Immune System Group, Department of Cell Biology and Histology,
Faculty of Biology, Regional Campus of International Excellence "Campus Mare
Nostrum", University of Murcia, 30100 Murcia, Spain.
AU - �ngeles Esteban M
AD - Fish Innate Immune System Group, Department of Cell Biology and Histology,
Faculty of Biology, Regional Campus of International Excellence "Campus Mare
Nostrum", University of Murcia, 30100 Murcia, Spain. Electronic address:
aesteban@um.es.
SO - Mar Pollut Bull. 2018, Mar; 128:324-332. [Marine pollution bulletin]
AB - Inorganic arsenic (As) is one of the most toxic pollutants in the water.
We have studied their effects on the marine teleost European sea bass
(Dicentrarchus labrax) at 2 and 10&#8239;days of 5&#8239;&mu;M of As2O3
(sub-lethal doses) waterborne exposure. Arsenic accumulates in liver and
gill tissues. The expression profile of five genes (bax, blc2, casp3,
casp8 and casp9) involved in apoptosis cell death confirmed apoptotic
effects in liver, slight changes in gill and no effects in skin according
with the histopathology findings. Total IgM level and peroxidase
activities were increased at 2 and 10&#8239;days, respectively. The
bactericidal activity was decreased at 2&#8239;days after As exposure. A
general decrease of cellular immune activities with significant
differences in the case of respiratory burst activity was observed after 2
and 10&#8239;days of exposure. This work describes for the first time the
effects of As exposure on European sea bass.
KW - Apoptosis
KW - Arsenic
KW - European sea bass (Dicentrarchus labrax)
KW - Immunotoxicology
LA - eng
IS - 1879-3363 (Electronic)
PT - Journal Article
TA - Mar Pollut Bull
YR - 2018
DATE- 20180324
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Marine pollution bulletin
EDAT- 20180206
STAT- In-Process
DOCNO- medline/29571380

129 - TOXLINE
TI - Urinary Arsenic in Human Samples from Areas Characterized by Natural or
Anthropogenic Pollution in Italy.
AU - Minichilli F
AD - National Research Council-Institute of Clinical Physiology, 56100 Pisa,
Italy. fabrizio.minichilli@ifc.cnr.it.
AU - Bianchi F
AD - National Research Council-Institute of Clinical Physiology, 56100 Pisa,
Italy. fabriepi@ifc.cnr.it.
AU - Ronchi AM
AD - Laboratory of Experimental and Clinical Toxicology, Maugeri Clinical
Scientific Institutes, 27100 Pavia, Italy. anna.ronchi@fsm.it.
AU - Gorini F
AD - National Research Council-Institute of Clinical Physiology, 56100 Pisa,
Italy. francesca.gorini@gmail.com.
AU - Bustaffa E
AD - National Research Council-Institute of Clinical Physiology, 56100 Pisa,
Italy. elisa.bustaffa@ifc.cnr.it.
SO - Int J Environ Res Public Health. 2018, Feb 09. [International journal of
environmental research and public health]
AB - Arsenic is ubiquitous and has a potentially adverse impact on human
health. We compared the distribution of concentrations of urinary
inorganic arsenic plus methylated forms (uc(iAs+MMA+DMA)) in four Italian
areas with other international studies, and we assessed the relationship
between uc(iAs+MMA+DMA) and various exposure factors. We conducted a human
biomonitoring study on 271 subjects (132 men) aged 20-44, randomly sampled
and stratified by area, gender, and age. Data on environmental and
occupational exposure and dietary habits were collected through a
questionnaire. Arsenic was speciated using chromatographic separation and
inductively coupled mass spectrometry. Associations between
uc(iAs+MMA+DMA) and exposure factors were evaluated using the geometric
mean ratio (GMR) with a 90% confidence interval by stepwise multiple
regression analysis. The 95th percentile value of uc(iAs+MMA+DMA) for the
whole sample (86.28 &micro;g/L) was higher than other national studies
worldwide. A statistical significant correlation was found between
uc(iAs+MMA+DMA) and occupational exposure (GMR: 2.68 [1.79-4.00]), GSTT
gene (GMR: 0.68 [0.52-0.80]), consumption of tap water (GMR: 1.35
[1.02-1.77]), seafood (GMR: 1.44 [1.11-1.88]), whole milk (GMR: 1.34
[1.04-1.73]), and fruit/vegetables (GMR: 1.37 [1.03-1.82]). This study
demonstrated the utility of uc(iAs+MMA+DMA) as a biomarker to assess
environmental exposure. In a public health context, this information could
be used to support remedial action, to prevent individuals from being
further exposed to environmental arsenic sources.
COI - The authors declare no conflict of interest.
KW - arsenic
KW - biomarker
KW - biomonitoring
KW - epidemiology
KW - urinary species
LA - eng
IS - 1660-4601 (Electronic)
PT - Journal Article
TA - Int J Environ Res Public Health
YR - 2018
DATE- 20180209
CITO- NLM
CS - Switzerland
FJT - International journal of environmental research and public health
EDAT- 20180209
STAT- In-Data-Review
DOCNO- medline/29425136

130 - TOXLINE
TI - Dimethylarsinic acid modulates the aryl hydrocarbon receptor-regulated
genes in C57BL/6 mice: in vivo study.
AU - Elshenawy OH
AD - a Faculty of Pharmacy and Pharmaceutical Sciences , University of Alberta ,
Edmonton , AB , Canada.
AU - Abdelhamid G
AD - b Department of Pharmacology and Toxicology , Faculty of Pharmacy, Helwan
University , Greater Cairo , Egypt , and.
AU - Althurwi HN
AD - c Department of Pharmacology , College of Pharmacy, Prince Sattam Bin
Abdulaziz University , Al Kharj , Kingdom of Saudi Arabia.
AU - El-Kadi AOS
AD - a Faculty of Pharmacy and Pharmaceutical Sciences , University of Alberta ,
Edmonton , AB , Canada.
SO - Xenobiotica. 2018, Feb; 48(2):124-134. [Xenobiotica; the fate of foreign
compounds in biological systems]
AB - 1.&emsp;Dimethylarsinic acid (DMA(V)) is the major metabolite of inorganic
arsenic in human body. Thus we investigated the effect of DMA(V) on the
alteration of phase I (typified by Cyp1a) and phase II (typified by Nqo1)
AhR-regulated genes in vivo. C57BL/6 mice received DMA(V)
(13.3&thinsp;mg/kg, i.p.) with or without TCDD (15&thinsp;&mu;g/kg, i.p.),
thereafter the liver, lung, and kidney were harvested at 6 and 24&thinsp;h
post-treatment. 2.&emsp;Results demonstrated that DMA(V) has no
significant effect on Cyp1a mRNA and protein expression or catalytic
activity in the liver. On the other hand, DMA(V) significantly potentiated
the TCDD-mediated induction of Cyp1a mRNA and protein expression, with a
subsequent potentiation of catalytic activity in the lung. Moreover,
DMA(V) significantly inhibited the TCDD-mediated induction of Cyp1a mRNA
and protein expression with subsequent inhibition of catalytic activity in
the kidney. 3.&emsp;Regarding to phase II AhR-regulated genes, DMA(V) has
no significant effect on Nqo1 mRNA and protein expression, or activity
neither in the liver, lung, or kidney. 4.&emsp;In conclusion, the present
work demonstrates for the first time that DMA(V) modulates AhR-regulated
genes in a tissue- and enzyme-specific manner. This modulation may play a
crucial role in arsenic-induced toxicity and carcinogenicity.
KW - AhR
KW - Cyp1a
KW - DMA(V)
KW - Nqo1
KW - arsenic
KW - cacodylic acid
KW - carcinogen-activating enzymes
KW - dimethylarsinic acid
RN - AJ2HL7EU8K
RN - EC 1.6.5.2
LA - eng
IS - 1366-5928 (Electronic)
PT - Journal Article
TA - Xenobiotica
YR - 2018
DATE- 20180102
CITO- NLM
CS - England
CSET- IM
FJT - Xenobiotica; the fate of foreign compounds in biological systems
EDAT- 20170221
STAT- MEDLINE
DOCNO- medline/28134025

131 - TOXLINE
TI - The secretome of adipose-derived mesenchymal stem cells protects SH-SY5Y
cells from arsenic-induced toxicity, independent of a neuron-like
differentiation mechanism.
AU - Curtis TM
AD - Department of Biological Sciences, State University of New York at Cortland,
Cortland, NY, United States. Electronic address: Theresa.curtis@cortland.edu.
AU - Hannett JM
AD - Department of Biological Sciences, State University of New York at Cortland,
Cortland, NY, United States.
AU - Harman RM
AD - Baker Institute for Animal Health, College of Veterinary Medicine, Cornell
University, Ithaca, NY, United States.
AU - Puoplo NA
AD - Department of Biological Sciences, State University of New York at Cortland,
Cortland, NY, United States.
AU - Van de Walle GR
AD - Baker Institute for Animal Health, College of Veterinary Medicine, Cornell
University, Ithaca, NY, United States.
SO - Neurotoxicology. 2018, Apr 13; 67:54-64. [Neurotoxicology]
AB - Arsenic exposure through contaminated food, water, and air causes
irreversible neural damage and affects millions of people worldwide.
Several studies have demonstrated that the secreted factors (secretome)
from mesenchymal stromal/stem cells (MSCs) can promote neural recovery
after several forms of injury including stroke and neurodegenerative
diseases. The present study was conducted to determine if the secretome
from adipose-derived MSCs (ADSCs) prevents arsenic damage to SH-SY5Y
cells. To this end, human neuroblastoma cells (SH-SY5Y) were pre-treated
with the secretome from ADSCs and then challenged with different
concentrations of arsenic. After various doses and exposure times, the
extent of neuronal injury was assessed using MTT reduction and LDH release
assays as well as LIVE/DEAD staining. These data demonstrate that the ADSC
secretome protects SH-SY5Y cells from arsenic-induced toxicity. Previous
reports have shown that the secretome of MSCs can induce neuroblast
differentiation and mature neurons are less susceptible to
chemical-induced toxicity. In the current study, proliferation assays,
neurite length assessment, and quantitative RT-PCR of differentiation
markers indicated that the ADSC secretome does not induce SH-SY5Y
differentiation into a mature neuron-like phenotype. In contrast, our
results demonstrated that soluble factor(s) in the ADSC secretome enhance
SH-SY5Y cell substrate-dependent adhesion. The present study is the first
to illustrate that the secretome from ADSCs protects SH-SY5Y cells from
arsenic-induced toxicity. Additionally, we showed that protection against
arsenic toxicity is not dependent on SH-SY5Y cell differentiation into a
mature neuron-like phenotype, but involves soluble factor(s) in the
secretome that appear to enhance cell survival by an adhesion-dependent
mechanism.
KW - Arsenic
KW - Cell adhesion
KW - Cell differentiation
KW - Mesenchymal stem cells
KW - Neuroprotection
KW - SH-SY5Y cells
KW - Secretome
LA - eng
IS - 1872-9711 (Electronic)
PT - Journal Article
TA - Neurotoxicology
YR - 2018
DATE- 20180616
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Neurotoxicology
EDAT- 20180413
STAT- Publisher
DOCNO- medline/29660375

132 - TOXLINE
TI - Vacuolar Phosphate Transporter 1 (VPT1) Affects Arsenate Tolerance by
Regulating Phosphate Homeostasis in Arabidopsis.
AU - Luan M
AD - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University-
Nanjing Forestry University Joint Institute for Plant Molecular Biology, School of
Life Sciences, Nanjing University, Nanjing 210093, PR China.
AU - Liu J
AD - College of Animal Science &amp; Technology, Northwest A&amp;F University,
Yangling, Shanxi, 712100, China.
AU - Liu Y
AD - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University-
Nanjing Forestry University Joint Institute for Plant Molecular Biology, School of
Life Sciences, Nanjing University, Nanjing 210093, PR China.
AU - Han X
AD - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University-
Nanjing Forestry University Joint Institute for Plant Molecular Biology, School of
Life Sciences, Nanjing University, Nanjing 210093, PR China.
AU - Sun G
AD - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University-
Nanjing Forestry University Joint Institute for Plant Molecular Biology, School of
Life Sciences, Nanjing University, Nanjing 210093, PR China.
AU - Lan W
AD - State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University-
Nanjing Forestry University Joint Institute for Plant Molecular Biology, School of
Life Sciences, Nanjing University, Nanjing 210093, PR China.
AU - Luan S
AD - Department of Plant and Microbial Biology, University of California,
Berkeley, CA 94720, USA.
SO - Plant Cell Physiol. 2018, Feb 06. [Plant & cell physiology]
AB - Arsenate [As(V)] is toxic to nearly all organisms. Soil-borne As(V) enters
plant cells mainly through the plasma membrane-localized phosphate (Pi)
transporters PHT1 family proteins due to its chemical similarity to Pi. We
report here that VPT1, a major vacuolar phosphate transporter contributes
to vacuolar Pi sequestration, is associated with As(V) tolerance in
Arabidopsis. vpt1 mutants displayed enhanced tolerance to As(V) toxicity,
whereas plants overexpressing VPT1 were more sensitive to As(V) as
compared to the wild type plants. Measurements of arsenic content
indicated that vpt1 mutants accumulated less arsenic and, in the contrast,
upregulating VPT1 expression contributed to higher levels of arsenic
accumulation in plants. To examine further how VPT1 may modulate arsenic
contents in plants, we surveyed the expression patterns of all the PHT1
family members that play roles in As(V) uptake and found that many of PHT1
genes were down regulated in the vpt1 mutant as compared to WT under Pi
sufficient condition, but not when Pi levels were low in medium.
Interestingly, As(V) sensitivity assays indicated that As(V) resistance in
vpt1 mutants were prominent only under Pi-sufficient but not under
Pi-deficient condition. These results suggest that under Pi-sufficient
condition, loss of VPT1 leads to elevated levels of Pi in the cytosol,
which in turn suppressed the expression of PHT1-type transporters and
reduced accumulation of arsenic.
KW - As(V) tolerance
KW - PHT1 genes
KW - Phosphate balance
KW - Vacuolar Phosphate Transporter1
LA - eng
IS - 1471-9053 (Electronic)
PT - Journal Article
TA - Plant Cell Physiol
YR - 2018
DATE- 20180208
CI - &copy; The Author 2018. Published by Oxford University Press on behalf of
Japanese Society of Plant Physiologists. All rights reserved. For
Permissions, please e-mail: journals.permissions@oup.com.
CITO- NLM
CS - Japan
FJT - Plant &amp; cell physiology
EDAT- 20180206
STAT- Publisher
DOCNO- medline/29420798

133 - TOXLINE
TI - The Arsenic Contamination of Drinking and Groundwaters in Bangladesh:
Featuring Biogeochemical Aspects and Implications on Public Health.
AU - Raessler M
AD - Max-Planck-Institut f�r Biogeochemie, Hans-Knoell-Strasse 10, PF 100164,
07745, Jena, Germany. raessler@bgc-jena.mpg.de.
SO - Arch Environ Contam Toxicol. 2018, Jul; 75(1):1-7. [Archives of
environmental contamination and toxicology]
AB - Arsenic is a widespread contaminant of drinking and groundwaters in the
world. Even if these contaminations have a geogenic origin, they often are
exacerbated by anthropogenic activities. This is particularly true for the
Bengal delta. Millions of people in Bangladesh are consuming drinking
water with arsenic concentrations &ge; 50 &micro;g/L. Their
drinking water supply is based on groundwaters extracted by pumping wells,
which were part of a well-drilling program by the United Nations. The
intention was to provide the people with groundwater instead of surface
water due to its critical hygienic conditions. Unfortunately, many wells
extract the groundwater at depths where arsenic concentrations are
highest. Arsenic is being dissolved from the aquifer by biogeochemical
processes that are fueled by the presence of high amounts of organics in
the Bengal delta sediments. This problem was not encountered at the time
due to a lack of chemical analyses of the waters.
RN - N712M78A8G
LA - eng
IS - 1432-0703 (Electronic)
PT - Journal Article
PT - Review
TA - Arch Environ Contam Toxicol
YR - 2018
DATE- 20180618
CITO- NLM
CS - United States
CSET- IM
FJT - Archives of environmental contamination and toxicology
EDAT- 20180308
STAT- MEDLINE
CM - Cites: Food Chem. 2017 Nov 1;234:76-80 (medline /28551270)
CM - Cites: Environ Health. 2014 Dec 04;13:101 (medline /25471535)
CM - Cites: Sci Total Environ. 2000 Aug 30;258(3):171-81 (medline /11007288)
CM - Cites: Environ Int. 2009 May;35(4):743-59 (medline /19232730)
CM - Cites: Sci Total Environ. 2017 Dec 1;601-602:122-131 (medline /28550725)
CM - Cites: Int J Epidemiol. 1998 Oct;27(5):871-7 (medline /9839746)
CM - Cites: Water Res. 2010 Nov;44(19):5556-74 (medline /20875661)
CM - Cites: Bull World Health Organ. 2000;78(9):1093-103 (medline /11019458)
CM - Cites: Ecotoxicol Environ Saf. 2015 Feb;112:247-70 (medline /25463877)
CM - Cites: PLoS One. 2015 Jul 22;10(7):e0131608 (medline /26200355)
CM - Cites: Environ Res. 2016 Nov;151:671-688 (medline /27619212)
CM - Cites: Environ Health Perspect. 2008 Jul;116(7):963-9 (medline /18629322)
CM - Cites: Chemosphere. 2016 Sep;158:37-49 (medline /27239969)
CM - Cites: Environ Sci Technol. 2009 Mar 1;43(5):1612-7 (medline /19350943)
CM - Cites: Nature. 2008 Jul 24;454(7203):505-8 (medline /18650922)
CM - Cites: Arch Environ Contam Toxicol. 2013 Jan;64(1):151-9 (medline
/23052359)
CM - Cites: Science. 2002 Nov 22;298(5598):1602-6 (medline /12446905)
CM - Cites: Science. 2003 May 9;300(5621):939-44 (medline /12738852)
CM - Cites: Trends Microbiol. 2005 Feb;13(2):45-9 (medline /15680760)
CM - Cites: Sci Total Environ. 2007 Jul 1;379(2-3):180-9 (medline /17067657)
CM - Cites: Environ Sci Technol. 2016 Apr 5;50(7):3469-76 (medline /27010474)
CM - Cites: Sci Total Environ. 2015 Sep 15;527-528:540-51 (medline /26004539)
CM - Cites: Environ Sci Technol. 2014 May 6;48(9):4699-706 (medline /24712677)
DOCNO- medline/29520432

134 - TOXLINE
TI - Arsenic exposure during embryonic development alters the expression of the
long noncoding RNA growth arrest specific-5 (Gas5) in a sex-dependent
manner.
AU - Caldwell KK
AD - Department of Neurosciences, University of New Mexico Health Sciences Center,
Albuquerque, NM 87131, United States.
AU - Hafez A
AD - Department of Neurosciences, University of New Mexico Health Sciences Center,
Albuquerque, NM 87131, United States.
AU - Solomon E
AD - Department of Neurosciences, University of New Mexico Health Sciences Center,
Albuquerque, NM 87131, United States.
AU - Cunningham M
AD - Department of Neurosciences, University of New Mexico Health Sciences Center,
Albuquerque, NM 87131, United States.
AU - Allan AM
AD - Department of Neurosciences, University of New Mexico Health Sciences Center,
Albuquerque, NM 87131, United States. Electronic address: aallan@salud.unm.edu.
SO - Neurotoxicol Teratol. 2018 Mar - Apr; 66:102-112. [Neurotoxicology and
teratology]
AB - Our previous studies suggest that prenatal arsenic exposure (50ppb)
modifies epigenetic control of the programming of the glucocorticoid
receptor (GR) signaling system in the developing mouse brain. These
deficits may lead to long-lasting consequences, including deficits in
learning and memory, increased depressive-like behaviors, and an altered
set-point of GR feedback throughout life. To understand the
arsenic-induced changes within the GR system, we assessed the impact of in
utero arsenic exposure on the levels of the GR and growth
arrest-specific-5 (Gas5), a noncoding RNA, across a key gestational period
for GR programming (gestational days, GD 14-18) in mice. Gas5 contains a
glucocorticoid response element (GRE)-like sequence that binds the GR,
thereby decreasing GR-GRE-dependent gene transcription and potentially
altering GR programming. Prenatal arsenic exposure resulted in
sex-dependent and age-dependent shifts in the levels of GR and Gas5
expression in fetal telencephalon. Nuclear GR levels were reduced in
males, but unchanged in females, at all gestational time points tested.
Total cellular Gas5 levels were lower in arsenic-exposed males with no
changes seen in arsenic-exposed females at GD16 and 18. An increase in
total cellular Gas-5 along with increased nuclear levels in GD14
arsenic-exposed females, suggests a differential regulation of cellular
compartmentalization of Gas5. RIP assays revealed reduced Gas5 associated
with the GR on GD14 in the nuclear fraction prepared from arsenic-exposed
males and females. This decrease in levels of GR-Gas5 binding continued
only in the females at GD18. Thus, nuclear GR signaling potential is
decreased in prenatal arsenic-exposed males, while it is increased or
maintained at levels approaching normal in prenatal arsenic-exposed
females. These findings suggest that females, but not males, exposed to
arsenic are able to regulate the levels of nuclear free GR by altering
Gas5 levels, thereby keeping GR nuclear signaling closer to control
(unexposed) levels.
KW - Arsenic
KW - Brain
KW - Development
KW - Gas5
KW - Glucocorticoid
KW - Sex differences
KW - lncRNA
LA - eng
IS - 1872-9738 (Electronic)
PT - Journal Article
TA - Neurotoxicol Teratol
YR - 2018
DATE- 20180318
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Neurotoxicology and teratology
EDAT- 20171111
STAT- In-Data-Review
CM - Cites: Alcohol Clin Exp Res. 2006 Dec;30(12):2055-64 (medline /17117971)
CM - Cites: Mol Cell Biol. 1992 Aug;12(8):3514-21 (medline /1630459)
CM - Cites: Nat Rev Genet. 2004 Jul;5(7):522-31 (medline /15211354)
CM - Cites: Environ Health Perspect. 2012 Aug;120(8):1208-14 (medline
/22504586)
CM - Cites: Curr Mol Med. 2015;15(1):94-9 (medline /25601472)
CM - Cites: Nucleic Acids Res. 2015 Apr 20;43(7):3712-25 (medline /25779046)
CM - Cites: PLoS One. 2013 Sep 03;8(9):e73720 (medline /24019935)
CM - Cites: Environ Res. 2001 Oct;87(2):92-8 (medline /11683592)
CM - Cites: Front Physiol. 2015 Aug 19;6:230 (medline /26347657)
CM - Cites: Biochem J. 1998 Feb 15;330 ( Pt 1):573-9 (medline /9461558)
CM - Cites: Epigenetics. 2017 Aug;12 (8):607-615 (medline /28548590)
CM - Cites: BMC Cancer. 2012 Aug 29;12 :378 (medline /22931209)
CM - Cites: J Appl Toxicol. 2014 May;34(5):498-505 (medline /23765520)
CM - Cites: Early Hum Dev. 2004 Jan;76(1):47-54 (medline /14729162)
CM - Cites: Am J Public Health. 2004 Nov;94(11):1936-7 (medline /15514231)
CM - Cites: Endocrinology. 2002 Oct;143(10):3866-74 (medline /12239098)
CM - Cites: Sci Signal. 2010 Feb 02;3(107):ra8 (medline /20124551)
CM - Cites: J Biol Chem. 2015 Nov 20;290(47):28286-98 (medline /26446789)
CM - Cites: Oncogene. 2009 Jan 15;28(2):195-208 (medline /18836484)
CM - Cites: J Endocrinol. 2004 Apr;181(1):105-16 (medline /15072571)
CM - Cites: Oncol Res Treat. 2015;38(7-8):362-6 (medline /26278580)
CM - Cites: Mol Cell Biol. 1998 Dec;18(12):6897-909 (medline /9819378)
CM - Cites: Environ Health Perspect. 2011 Feb;119(2):258-64 (medline /20940111)
CM - Cites: Neurotoxicol Teratol. 2016 Jan-Feb;53:75-80 (medline /26689609)
CM - Cites: Neuroscience. 2017 Feb 7;342:4-20 (medline /26232714)
CM - Cites: Neurotoxicology. 2008 Jul;29(4):647-55 (medline /18573533)
CM - Cites: Toxicol Rep. 2015 Oct;2:1376-1390 (medline /26855884)
CM - Cites: Toxicol Sci. 2007 Sep;99(1):244-53 (medline /17569693)
CM - Cites: Environ Res. 2011 Jul;111(5):670-6 (medline /21439564)
CM - Cites: Biomed Res Int. 2013;2013:358015 (medline /24319682)
CM - Cites: J Dev Orig Health Dis. 2017 Apr;8(2):244-255 (medline /28103963)
CM - Cites: Environ Health. 2014 Mar 12;13(1):15 (medline /24621105)
CM - Cites: Clin Cancer Drugs. 2015;2(2):138-147 (medline /27054085)
CM - Cites: Brain Res Dev Brain Res. 1995 Jan 14;84(1):55-61 (medline /7720217)
CM - Cites: J Pharmacol Exp Ther. 2010 Oct;335(1):114-23 (medline /20605902)
CM - Cites: Mol Med. 1996 Nov;2(6):735-44 (medline /8972488)
CM - Cites: Mol Reprod Dev. 1997 Nov;48(3):310-6 (medline /9322241)
CM - Cites: Biochim Biophys Acta. 2013 Oct;1832(10):1613-23 (medline /23676682)
CM - Cites: Neurosci Biobehav Rev. 2017 May 18;:null (medline /28528960)
CM - Cites: Sci China Life Sci. 2016 Mar;59(3):227-35 (medline /26825947)
CM - Cites: Hippocampus. 2010 Sep;20(9):1027-36 (medline /19739230)
CM - Cites: Endocrinology. 2013 Dec;154(12):4560-9 (medline /24064364)
CM - Cites: Neurotoxicology. 2012 Oct;33(5):1338-45 (medline /22960421)
CM - Cites: Neurotoxicol Teratol. 2017 Jan - Feb;59:1-15 (medline /27751817)
CM - Cites: J Neuroendocrinol. 2016 Aug;28(8): (medline /26708929)
CM - Cites: J Cell Sci. 2008 Apr 1;121(Pt 7):939-46 (medline /18354083)
CM - Cites: Am J Hum Biol. 2010 May-Jun;22(3):330-5 (medline /19844898)
CM - Cites: J R Soc Interface. 2012 Dec 12;10(79):20120835 (medline /23235262)
CM - Cites: Am J Respir Crit Care Med. 2003 Dec 1;168(11):1317-23 (medline
/14500261)
CM - Cites: Biochim Biophys Acta. 2014 Mar;1840(3):1063-71 (medline /24184936)
CM - Cites: Sci Rep. 2015 May 11;5:10159 (medline /25959498)
CM - Cites: Int J Hyg Environ Health. 2014 Jul;217(6):678-86 (medline
/24698386)
CM - Cites: Pharmacol Biochem Behav. 2009 Dec;94(2):271-7 (medline /19751756)
CM - Cites: Physiol Behav. 2000 Nov 1-15;71(3-4):353-62 (medline /11150568)
CM - Cites: Environ Health. 2016 Mar 12;15:44 (medline /26968381)
CM - Cites: J Neuroendocrinol. 2014 Oct;26(10):707-23 (medline /25039443)
CM - Cites: Genes Dev. 2007 Aug 15;21(16):1993-8 (medline /17675447)
CM - Cites: Annu Rev Nutr. 2009;29:381-99 (medline /19575603)
CM - Cites: Genome Biol. 2015 Jan 29;16:20 (medline /25630241)
CM - Cites: Nat Neurosci. 2004 Aug;7(8):847-54 (medline /15220929)
CM - Cites: Curr Environ Health Rep. 2014 Mar 21;1:132-147 (medline /24860722)
CM - Cites: J Physiol. 2014 Jul 15;592(14 ):3127-41 (medline /24801305)
CM - Cites: Cell. 1988 Sep 9;54(6):787-93 (medline /3409319)
CM - Cites: Methods Mol Biol. 2004;261:15-32 (medline /15064447)
CM - Cites: Neuroscience. 2016 Apr 21;320:43-56 (medline /26844389)
CM - Cites: Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F182-5 (medline
/11040165)
CM - Cites: Nucleic Acids Res. 2006 Mar 31;34(6):1765-71 (medline /16582102)
CM - Cites: EMBO J. 2014 May 2;33(9):937-8 (medline /24719208)
CM - Cites: Neurotoxicol Teratol. 2015 Jan-Feb;47:66-79 (medline /25459689)
CM - Cites: Birth Defects Res. 2017 Jul 17;109 (12 ):888-897 (medline
/28714605)
CM - Cites: Toxicol Appl Pharmacol. 2015 Oct 1;288(1):40-51 (medline /26193056)
CM - Cites: Trends Biochem Sci. 2016 Sep;41(9):761-772 (medline /27499234)
CM - Cites: Trends Cell Biol. 2017 Sep;27(9):685-696 (medline /28528987)
CM - Cites: Science. 2007 Jun 8;316(5830):1484-8 (medline /17510325)
CM - Cites: Environ Toxicol Pharmacol. 2012 Sep;34(2):381-387 (medline
/22728250)
CM - Cites: Ann N Y Acad Sci. 2004 Jun;1024:182-212 (medline /15265782)
CM - Cites: Endocrinology. 2012 Oct;153(10):4749-56 (medline /22962254)
CM - Cites: Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14182-7 (medline
/8943081)
CM - Cites: Environ Res. 2017 Jul;156:74-79 (medline /28334644)
CM - Cites: Chem Soc Rev. 2008 Aug;37(8):1629-51 (medline /18648687)
CM - Cites: Am J Physiol Renal Physiol. 2015 May 15;308(10):F1065-73 (medline
/25715988)
CM - Cites: Int J Epidemiol. 2011 Dec;40(6):1593-604 (medline /22158669)
CM - Cites: J Endocrinol. 2017 Jan;232(1):37-48 (medline /27754933)
CM - Cites: Neurotoxicology. 2014 Sep;44:98-109 (medline /24952232)
CM - Cites: Crit Care Med. 2012 Oct;40(10):2745-53 (medline /22846781)
CM - Cites: J Endocrinol. 2013 Apr 15;217(2):161-73 (medline /23428582)
CM - Cites: Cell Death Differ. 2013 Nov;20(11):1558-68 (medline /23933812)
CM - Cites: Brain Res. 1992 Nov 13;595(2):195-200 (medline /1467966)
CM - Cites: Nat Commun. 2014 Nov 07;5:5395 (medline /25377354)
CM - Cites: PLoS One. 2013;8(1):e55684 (medline /23383264)
CM - Cites: PLoS One. 2015 Mar 24;10(3):e0120992 (medline /25803364)
CM - Cites: Anal Biochem. 2003 Sep 15;320(2):193-8 (medline /12927824)
CM - Cites: PLoS One. 2016 Jul 11;11(7):e0158807 (medline /27398996)
CM - Cites: Endocrinology. 2012 Nov;153(11):5500-11 (medline /22919064)
CM - Cites: Gend Med. 2007 Mar;4(1):19-30 (medline /17584623)
CM - Cites: Sci Rep. 2016 Nov 23;6:37227 (medline /27876813)
CM - Cites: Exp Clin Endocrinol. 1991;98(2):123-9 (medline /1663870)
CM - Cites: J Environ Health. 2011 Sep;74(2):16-22 (medline /21949980)
DOCNO- medline/29132937

135 - TOXLINE
TI - Arsenite and methylarsonite inhibit mitochondrial metabolism and
glucose-stimulated insulin secretion in INS-1 832/13 &beta; cells.
AU - Dover EN
AD - Curriculum in Toxicology, School of Medicine, University of North Carolina,
Chapel Hill, NC, USA.
AU - Beck R
AD - Department of Genetics, School of Medicine, University of North Carolina at
Chapel Hill, Chapel Hill, NC, USA.
AU - Huang MC
AD - Curriculum in Toxicology, School of Medicine, University of North Carolina,
Chapel Hill, NC, USA.
AU - Douillet C
AD - Department of Nutrition, CB# 74612, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, 27599-7461, USA.
AU - Wang Z
AD - School of Environmental Science and Engineering, Shandong University, No. 27
Shanda South Road, Jinan, 250100, China.
AU - Klett EL
AD - Department of Medicine, School of Medicine, University of North Carolina,
Chapel Hill, NC, USA.
AU - St�blo M
AD - Department of Nutrition, CB# 74612, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, 27599-7461, USA. styblo@med.unc.edu.
SO - Arch Toxicol. 2018, Feb; 92(2):693-704. [Archives of toxicology]
AB - Growing evidence suggests that exposure to environmental contaminants
contributes to the current diabetes epidemic. Inorganic arsenic (iAs), a
drinking water and food contaminant, is one of the most widespread
environmental diabetogens according to epidemiological studies. Several
schemes have been proposed to explain the diabetogenic effects of iAs
exposure; however, the exact mechanism remains unknown. We have shown that
in vitro exposure to low concentrations of arsenite (iAsIII) or its
trivalent methylated metabolites, methylarsonite (MAsIII) and
dimethylarsinite (DMAsIII), inhibits glucose-stimulated insulin secretion
(GSIS) from isolated pancreatic islets, with little effect on insulin
transcription or total insulin content. The goal of this study was to
determine if exposure to trivalent arsenicals impairs mitochondrial
metabolism, which plays a key role in the regulation of GSIS in &beta;
cells. We used a Seahorse extracellular flux analyzer to measure oxygen
consumption rate (OCR), a proxy for mitochondrial metabolism, in cultured
INS-1 832/13 &beta; cells exposed to iAsIII, MAsIII, or DMAsIII and
stimulated with either glucose or pyruvate, a final product of glycolysis
and a substrate for the Krebs cycle. We found that 24-h exposure to 2
&mu;M iAsIII or 0.375-0.5 &mu;M MAsIII inhibited OCR in both glucose- and
pyruvate-stimulated &beta; cells in a manner that closely paralleled GSIS
inhibition. In contrast, 24-h exposure to DMAsIII (up to 2 &micro;M)
had no effects on either OCR or GSIS. These results suggest that iAsIII
and MAsIII may impair GSIS in &beta; cells by inhibiting mitochondrial
metabolism, and that at least one target of these arsenicals is pyruvate
decarboxylation or downstream reactions.
KW - Arsenic
KW - Diabetes
KW - Insulin secretion
KW - Mitochondrial respiration
KW - β cells
LA - eng
IS - 1432-0738 (Electronic)
PT - Journal Article
TA - Arch Toxicol
YR - 2018
DATE- 20180220
CITO- NLM
CS - Germany
FJT - Archives of toxicology
EDAT- 20170927
STAT- In-Data-Review
DOCNO- medline/28956099

136 - TOXLINE
TI - Effective rhizoinoculation and biofilm formation by arsenic immobilizing
halophilic plant growth promoting bacteria (PGPB) isolated from mangrove
rhizosphere: A step towards arsenic rhizoremediation.
AU - Mallick I
AD - Department of Biochemistry, Bose Institute, P1/12, C.I.T Road, Scheme VIIM,
Kolkata 700054, West Bengal, India.
AU - Bhattacharyya C
AD - Department of Biochemistry, Bose Institute, P1/12, C.I.T Road, Scheme VIIM,
Kolkata 700054, West Bengal, India.
AU - Mukherji S
AD - Department of Biochemistry, Bose Institute, P1/12, C.I.T Road, Scheme VIIM,
Kolkata 700054, West Bengal, India.
AU - Dey D
AD - Department of Biochemistry, Bose Institute, P1/12, C.I.T Road, Scheme VIIM,
Kolkata 700054, West Bengal, India.
AU - Sarkar SC
AD - West Bengal Pollution Control Board, Kolkata, West Bengal, India.
AU - Mukhopadhyay UK
AD - West Bengal Pollution Control Board, Kolkata, West Bengal, India.
AU - Ghosh A
AD - Department of Biochemistry, Bose Institute, P1/12, C.I.T Road, Scheme VIIM,
Kolkata 700054, West Bengal, India. Electronic address:
abhrajyoti.ghosh@jcbose.ac.in.
SO - Sci Total Environ. 2018, Jan 01; 610-611:1239-1250. [The Science of the
total environment]
AB - Arsenic (As) uptake by plants is largely influenced by the presence of
microbial consortia and their interactions with As. In the coastal region
of Bengal deltaic plain of Eastern India, the As-contaminated groundwater
is frequently used for irrigation purposes resulting in an elevated level
of soil As in agricultural lands. The health hazards associated with As
necessitates development of cost-effective remediation strategies to
reclaim contaminated agricultural lands. Among the available technologies
developed in recent times, bioremediation using bacteria has been found to
be the most propitious. In this study, two As-resistant halophilic
bacterial strains Kocuria flava AB402 and Bacillus vietnamensis AB403 were
isolated, identified and characterized from mangrove rhizosphere of
Sundarban. The isolates, AB402 and AB403, could tolerate 35mM and 20mM of
arsenite, respectively. The effect of As on the exopolysaccharide (EPS)
synthesis, biofilm formation, and root association was evaluated for both
the bacterial strains. Arsenic adsorption on the cell surfaces and
intracellular accumulation in both the bacterial strains were promising
under culture conditions. Moreover, both the strains when used as
inoculum, not only promoted the growth of rice seedlings but also
decreased As uptake and accumulation in plants.
KW - Accumulation
KW - Adsorption
KW - Arsenic resistance
KW - Biofilm
KW - Halophiles
KW - Plant growth promoting rhizobacteria
RN - N712M78A8G
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180504
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20170830
STAT- MEDLINE
DOCNO- medline/28851144

137 - TOXLINE
TI - Ellagic acid attenuates arsenic induced neuro-inflammation and
mitochondrial dysfunction associated apoptosis.
AU - Firdaus F
AD - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University,
Aligarh, Uttar Pradesh, India.
AU - Zafeer MF
AD - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
AU - Anis E
AD - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
AU - Ahmad M
AD - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
AU - Afzal M
AD - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University,
Aligarh, Uttar Pradesh, India.
SO - Toxicol Rep. 2018; 5:411-417. [Toxicology reports]
AB - Arsenic, being a global pollutant needs a potential remedy which could
fight against its associated toxicities. Ellagic acid (EA) is a known
agent for its anti-inflammatory, antioxidant and antiapoptotic effects,
and it is commonly found in fruits. The present study is designed to
determine protective efficacy of EA against arsenic induced toxicity with
special mention to inflammation and mitochondrial dysfunction in
hippocampi of wistar rats. Rats were pre-treated with EA (20 and
40&#8239;mg/kg b.wt; p.o. for 11&#8239;days) along with arsenic
(10&#8239;mg/kg; p.o. for 8&#8239;days). Total reactive oxygen species
level and mitochondrial membrane potential were analyzed using flow
cytometry. Protein and mRNA expression of apoptotic and inflammatory
markers were also evaluated in rat hippocampus. Our results show that
arsenic exposure increased total ROS generation and DNA fragmentation,
decreased mitochondrial membrane potential alongwith an increase in
expression of pro-apoptotic and inflammatory markers. suggesting that EA
complementation downregulated total ROS generation dose dependently.
Apoptotic markers, BAX and Bcl2 as well as inflammatory markers,
IL-1&beta;, TNF&alpha;, INF&gamma; got altered significantly on its
administration. Moreover, it also attenuated effects on mitochondrial
membrane potential. Based on our findings, EA might substantiate to be a
budding therapeutic candidate against arsenic induced neurotoxicity.
KW - Arsenic
KW - Ellagic acid
KW - Inflammation
KW - Mitochondrial membrane potential
KW - Neurotoxicity
KW - ROS generation
LA - eng
IS - 2214-7500 (Electronic)
PT - Journal Article
TA - Toxicol Rep
YR - 2018
DATE- 20180603
CITO- NLM
CS - Ireland
FJT - Toxicology reports
EDAT- 20180309
STAT- PubMed-not-MEDLINE
CM - Cites: Toxicol Lett. 2003 Nov 1;145(1):1-18 (medline /12962969)
CM - Cites: Int J Oncol. 2000 May;16(5):871-86 (medline /10762622)
CM - Cites: J Biol Chem. 2010 Dec 17;285(51):39922-34 (medline /20889981)
CM - Cites: Environ Toxicol Pharmacol. 2012 May;33(3):394-402 (medline
/22387601)
CM - Cites: Brain Res. 2017 May 1;1662:23-30 (medline /28238669)
CM - Cites: Free Radic Biol Med. 1996;21(6):783-90 (medline /8902524)
CM - Cites: Trends Cell Biol. 2000 Sep;10(9):369-77 (medline /10932094)
CM - Cites: Cell. 2010 Mar 19;140(6):918-34 (medline /20303880)
CM - Cites: Trends Cell Biol. 2001 Dec;11(12):526-34 (medline /11719060)
CM - Cites: Toxicol Lett. 2009 Jan 30;184(2):121-5 (medline /19041379)
CM - Cites: Mol Biol Cell. 2002 Mar;13(3):978-88 (medline /11907276)
CM - Cites: J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct
25;796(1):189-94 (medline /14552830)
CM - Cites: Digestion. 2001;64(4):214-21 (medline /11842277)
CM - Cites: J Nutr. 2001 Nov;131(11):2837-42 (medline /11694605)
CM - Cites: Immunology. 2010 Feb;129(2):154-69 (medline /20561356)
CM - Cites: J Agric Food Chem. 2002 Apr 10;50(8):2432-8 (medline /11929309)
CM - Cites: Environ Res. 2006 Jul;101(3):349-55 (medline /16458287)
CM - Cites: Environ Health Perspect. 2007 Sep;115(9):1371-5 (medline /17805430)
CM - Cites: J Toxicol Clin Toxicol. 2001;39(7):675-82 (medline /11778665)
CM - Cites: Neurol Sci. 2012 Jun;33(3):567-74 (medline /21922312)
CM - Cites: Psychopharmacology (Berl). 2017 Jun;234(12 ):1841-1852 (medline
/28303372)
CM - Cites: Science. 2004 Jul 30;305(5684):626-9 (medline /15286356)
CM - Cites: Toxicol Appl Pharmacol. 2009 Oct 15;240(2):236-44 (medline
/19460394)
CM - Cites: Toxicol Lett. 2005 Jan 15;155(1):27-34 (medline /15585356)
CM - Cites: J Signal Transduct. 2012;2012:329635 (medline /22175013)
CM - Cites: Mutat Res. 2003 Dec 10;533(1-2):173-82 (medline /14643419)
CM - Cites: BMC Biol. 2015 Oct 29;13:89 (medline /26515107)
CM - Cites: Exp Cell Res. 1988 Mar;175(1):184-91 (medline /3345800)
CM - Cites: Free Radic Biol Med. 2011 Jul 15;51(2):257-81 (medline /21554949)
CM - Cites: Food Chem Toxicol. 2010 Jan;48(1):326-35 (medline /19852998)
CM - Cites: J Agric Food Chem. 2002 Mar 27;50(7):2200-6 (medline /11902978)
CM - Cites: Cytotechnology. 2016 Oct;68(5):1763-70 (medline /26660314)
CM - Cites: Biomed Pharmacother. 2010 Apr;64(4):264-70 (medline /20347566)
CM - Cites: Neurotoxicol Teratol. 2009 Sep-Oct;31(5):318-22 (medline /19410645)
CM - Cites: J Cell Sci. 2008 Jan 1;121(Pt 1):75-85 (medline /18073239)
CM - Cites: Int J Environ Res Public Health. 2011 Jul;8(7):2980-3018 (medline
/21845170)
CM - Cites: Brain Res Bull. 2001 May 15;55(2):301-8 (medline /11470331)
CM - Cites: Cancer Lett. 1995 May 4;91(1):139-44 (medline /7750089)
CM - Cites: Environ Health Perspect. 1998 Aug;106(8):487-91 (medline /9681976)
CM - Cites: Int Immunopharmacol. 2014 Oct;22(2):341-5 (medline /25038320)
CM - Cites: Biochem Pharmacol. 1996 Feb 23;51(4):395-402 (medline /8619883)
CM - Cites: J Agric Food Chem. 2002 Jun 5;50(12):3495-500 (medline /12033817)
CM - Cites: Life Sci. 2002 Jan 25;70(10):1139-50 (medline /11848298)
CM - Cites: Mediators Inflamm. 2017;2017:5048616 (medline /28154473)
CM - Cites: Environ Mol Mutagen. 1995;26(3):248-54 (medline /7588651)
CM - Cites: Toxicol Lett. 1997 Aug 22;92(3):201-8 (medline /9334831)
CM - Cites: Toxicology. 2005 May 15;210(1):25-36 (medline /15804455)
CM - Cites: Circ Res. 2000 Mar 17;86(5):514-9 (medline /10720412)
CM - Cites: Mol Cell Oncol. 2014 Oct 31;1(2):e955995 (medline /27308326)
CM - Cites: J Biochem Mol Toxicol. 2008 Feb;22(1):15-26 (medline /18273903)
CM - Cites: Chem Res Toxicol. 2006 Jan;19(1):1-15 (medline /16411650)
DOCNO- medline/29854611

138 - TOXLINE
TI - Inhibition of miR-219 Alleviates Arsenic-Induced Learning and Memory
Impairments and Synaptic Damage Through Up-regulating CaMKII in the
Hippocampus.
AU - Wang D
AD - Department of Occupational and Environmental Health, Dalian Medical
University, Dalian, 116044, People's Republic of China.
AU - Wang X
AD - Digestive Endoscopic Department of the second Hospital of Jilin University,
Changchun, 130000, People's Republic of China.
AU - Liu X
AD - 3Department of Food Nutrition and Safety, Dalian Medical University, Dalian,
Liaoning, 116044, People's Republic of China.
AU - Jiang L
AD - Liaoning Anti-Degenerative Diseases Natural Products Engineering Research
Center, Dalian Medical University, Dalian, 116044, People's Republic of China.
AU - Yang G
AD - 3Department of Food Nutrition and Safety, Dalian Medical University, Dalian,
Liaoning, 116044, People's Republic of China.
AU - Shi X
AD - Department of Occupational and Environmental Health, Dalian Medical
University, Dalian, 116044, People's Republic of China.
AU - Zhang C
AD - 3Department of Food Nutrition and Safety, Dalian Medical University, Dalian,
Liaoning, 116044, People's Republic of China. congzhang1203@hotmail.com.
AU - Piao F
AD - Department of Occupational and Environmental Health, Dalian Medical
University, Dalian, 116044, People's Republic of China.
SO - Neurochem Res. 2018, Apr; 43(4):948-958. [Neurochemical research]
AB - Epidemiological investigations and experimental studies indicate that
chronic arsenic exposure can reduce learning and memory function. However,
the underlying mechanism of this effect remains largely unknown. Emerging
evidence suggests that microRNA (miRNA) play an important role in toxicant
exposure and a regulatory role in cognitive function. In this study, we
observed that subchronic arsenic exposure induced impairment of learning
and memory and significantly up-regulated miRNA-219 (miR-219) expression
in the mouse hippocampus. Furthermore, the expression of CaMKII, an
experimentally validated target of miR-219, was decreased in the mice
exposed to arsenic. Suppression of miR-219 by adeno-associated viral
(AAV)-delivered anti-miR-219 prevented the arsenic-induced impairment of
learning and memory and relieved the pathological changes in the synaptic
structure of the hippocampus. Furthermore, we observed that the NMDA
receptor subunit 2 (NR2) and the memory-related proteins c-Fos and c-Jun
were up-regulated by inhibition of miR-219 in the mouse hippocampus. Taken
together, the results of this study indicate that inhibition of miR-219
regulates arsenic-induced damage in the structure of the hippocampus and
impairment of learning and memory, possibly by targeting CaMKII.
Suppression of miR-219 may be a potential strategy to ameliorate
arsenic-induced neurotoxicity.
KW - Arsenic
KW - CaMKII
KW - Hippocampus
KW - Learning and memory
KW - miR-219
LA - eng
IS - 1573-6903 (Electronic)
PT - Journal Article
TA - Neurochem Res
YR - 2018
DATE- 20180410
CITO- NLM
CS - United States
FJT - Neurochemical research
EDAT- 20180224
STAT- In-Process
CM - Cites: Neurotoxicology. 2012 Oct;33(5):1033-9 (medline /22561869)
CM - Cites: J Exp Zool A Ecol Genet Physiol. 2009 Dec 1;311(10):763-75 (medline
/19658087)
CM - Cites: Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9093-8 (medline
/18577589)
CM - Cites: Trends Cell Biol. 2013 Jan;23(1):30-6 (medline /23026030)
CM - Cites: Neurotoxicology. 2006 Mar;27(2):210-6 (medline /16310252)
CM - Cites: J Biol Chem. 2014 Apr 4;289(14):10201-10 (medline /24554719)
CM - Cites: J Neurosci. 2011 Jun 22;31(25):9170-8 (medline /21697368)
CM - Cites: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3507-12 (medline
/19196972)
CM - Cites: Toxicol Lett. 2009 Jan 30;184(2):121-5 (medline /19041379)
CM - Cites: Adv Exp Med Biol. 2015;888:107-21 (medline /26663181)
CM - Cites: J Neurosci. 2014 Jul 16;34(29):9476-83 (medline /25031391)
CM - Cites: Environ Toxicol. 2015 May-Jun;30(6):712-23 (medline /24420840)
CM - Cites: Neuron. 2012 Aug 9;75(3):363-79 (medline /22884321)
CM - Cites: J Neurosci. 1996 Sep 1;16(17):5425-36 (medline /8757255)
CM - Cites: Psychopharmacology (Berl). 2004 May;173(3-4):337-45 (medline
/14985918)
CM - Cites: Genome Biol. 2004;5(3):R13 (medline /15003116)
CM - Cites: Oncotarget. 2017 Apr 25;8(17 ):28203-28214 (medline /28423675)
CM - Cites: Annu Rev Neurosci. 2008;31:47-67 (medline /18284372)
CM - Cites: Nat Rev Genet. 2008 Feb;9(2):102-14 (medline /18197166)
CM - Cites: Eur J Nutr. 2017 Mar;56(2):865-877 (medline /26695409)
CM - Cites: Neurotoxicology. 2010 Sep;31(5):575-81 (medline /20553758)
CM - Cites: Neurobiol Learn Mem. 2011 Jul;96(1):89-94 (medline /21524708)
CM - Cites: Taiwan Yi Xue Hui Za Zhi. 1962 Jul 28;61:611-8 (medline /14040660)
CM - Cites: Toxicol Lett. 2014 Aug 4;228(3):260-9 (medline /24831965)
CM - Cites: Toxicol Lett. 2012 May 20;211(1):39-44 (medline /22421273)
CM - Cites: Neuron. 2007 Jun 7;54(5):813-29 (medline /17553428)
CM - Cites: Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7945-50 (medline
/20351272)
CM - Cites: Trends Neurosci. 2012 May;35(5):325-34 (medline /22436491)
CM -Cites: Genes Dev. 2007 Apr 1;21(7):744-9 (medline /17403776)
CM -Cites: Neuron. 2008 May 22;58(4):571-83 (medline /18498738)
CM -Cites: Eur J Neurosci. 2010 Feb;31(4):636-45 (medline /20384810)
CM -Cites: J Comp Neurol. 2010 Oct 15;518(20):4243-60 (medline /20878786)
CM -Cites: Comp Biochem Physiol C Toxicol Pharmacol. 2012 May;155(4):566-72
(medline /22265774)
CM - Cites: J Neurosci. 2013 Oct 23;33(43):17008-22 (medline /24155305)
CM - Cites: Mol Med Rep. 2014 May;9(5):1715-22 (medline /24626427)
CM - Cites: Toxicol Lett. 2014 Aug 17;229(1):158-66 (medline /24960059)
CM - Cites: J Inorg Biochem. 2009 Nov;103(11):1591-5 (medline /19540598)
CM - Cites: J Neurosci. 2012 Apr 18;32(16):5678-5687 (medline /22514329)
CM - Cites: Nat Rev Neurosci. 2002 Mar;3(3):175-90 (medline /11994750)
CM - Cites: Environ Health Perspect. 2000 May;108(5):393-7 (medline /10811564)
CM - Cites: Stroke. 2008 Dec;39(12):3397-404 (medline /18772448)
CM - Cites: Toxicology. 2013 Jan 7;303:43-53 (medline /23146754)
CM - Cites: Am J Epidemiol. 1998 Jul 15;148(2):198-203 (medline /9676702)
CM - Cites: Neuroscience. 2008 Jan 2;151(1):43-55 (medline /18082335)
CM - Cites: Neuroreport. 2007 Feb 12;18(3):297-300 (medline /17314675)
CM - Cites: Environ Sci Technol. 2013 Jul 2;47(13):7466-74 (medline /23745839)
CM - Cites: Neurosci Lett. 1980 Apr;17(1-2):27-31 (medline /6302580)
CM - Cites: Cell. 2009 Jan 23;136(2):215-33 (medline /19167326)
CM - Cites: Science. 2002 Oct 25;298(5594):776-80 (medline /12399578)
CM - Cites: Biomed Res Int. 2015 ;2015 :302653 (medline /26649298)
CM - Cites: Neurotoxicology. 2012 Oct;33(5):1230-8 (medline /22824511)
CM - Cites: Curr Opin Genet Dev. 2011 Aug;21(4):491-7 (medline /21561760)
CM - Cites: Environ Health Perspect. 2004 Sep;112(13):1329-33 (medline
/15345348)
CM - Cites: BMC Genomics. 2014;15 Suppl 11:S1 (medline /25559034)
DOCNO- medline/29478199

139 - TOXLINE
TI - Arsenic removal by Japanese oak wood biochar in aqueous solutions and well
water: Investigating arsenic fate using integrated spectroscopic and
microscopic techniques.
AU - Niazi NK
AD - Institute of Soil and Environmental Sciences, University of Agriculture
Faisalabad, Faisalabad 38040, Pakistan; MARUM and Department of Geosciences,
University of Bremen, Bremen D-28359, Germany. Electronic address:
nabeel.niazi@uaf.edu.pk.
AU - Bibi I
AD - Institute of Soil and Environmental Sciences, University of Agriculture
Faisalabad, Faisalabad 38040, Pakistan; MARUM and Department of Geosciences,
University of Bremen, Bremen D-28359, Germany.
AU - Shahid M
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, Pakistan.
AU - Ok YS
AD - Korea Biochar Research Center, O-Jeong Eco-Resilience Institute (OJERI) &amp;
Division of Environmental Science and Ecological Engineering, Korea University,
Seoul, 02841, Republic of Korea.
AU - Shaheen SM
AD - University of Kafrelsheikh, Faculty of Agriculture, Department of Soil and
Water Sciences, 33 516 Kafr El-Sheikh, Egypt; University of Wuppertal, School of
Architecture and Civil Engineering, Institute of Foundation Engineering, Water- and
Waste-Management, Laboratory of Soil- and Groundwater-Management,
Pauluskirchstra&szlig;e 7, 42285 Wuppertal, Germany.
AU - Rinklebe J
AD - University of Wuppertal, School of Architecture and Civil Engineering,
Institute of Foundation Engineering, Water- and Waste-Management, Laboratory of
Soil- and Groundwater-Management, Pauluskirchstra&szlig;e 7, 42285 Wuppertal,
Germany; Department of Environment and Energy, Sejong University, 98 Gunja-Dong,
Guangjin-Gu, Seoul, Republic of Korea. Electronic address: rinklebe@uni-
wuppertal.de.
AU - Wang H
AD - Key Laboratory of Soil Contamination Bioremediation of Zhejiang Province,
Zhejiang A &amp; F University, Lin'an, Hangzhou 311300, China; School of
Environment and Chemical Engineering, Foshan University, Foshan 528000, China.
AU - Murtaza B
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, Pakistan.
AU - Islam E
AD - Environmental Biotechnology Division, National Institute for Biotechnology
and Genetic Engineering (NIBGE), Faisalabad 38000, Pakistan.
AU - Farrakh Nawaz M
AD - Department of Forestry and Range Management, University of Agriculture
Faisalabad, Faisalabad 38040, Pakistan.
AU - L�ttge A
AD - MARUM and Department of Geosciences, University of Bremen, Bremen D-28359,
Germany.
SO - Sci Total Environ. 2018, Apr 15; 621:1642-1651. [The Science of the total
environment]
AB - In this study, we examined the sorption of arsenite (As(III)) and arsenate
(As(V)) to Japanese oak wood-derived biochar (OW-BC) in aqueous solutions,
and determined its efficiency to remove As from As-contaminated well
water. Results revealed that, among the four sorption isotherm models,
Langmuir model showed the best fit to describe As(III) and As(V) sorption
on OW-BC, with slightly greater sorption affinity for As(V) compared to
As(III) (QL=3.89 and 3.16mgg-1; R2=0.91 and 0.85, respectively). Sorption
edge experiments indicated that the maximum As removal was 81% and 84% for
As(III)- and As(V)-OW-BC systems at pH7 and 6, respectively, which
decreased above these pH values (76-69% and 80-58%). Surface functional
groups, notably OH, COOH, CO, CH3, were involved in As sequestration by
OW-BC, suggesting the surface complexation/precipitation and/or
electrostatic interaction of As on OW-BC surface. Arsenic K-edge X-ray
absorption near edge structure (XANES) spectroscopy indicated that 36% of
the added As(III) was partially oxidized to As(V) in the As(III) sorption
experiment, and in As(V) sorption experiment, 48% of As(V) was, albeit
incompletely, reduced to As(III) on OW-BC surface. Application of OW-BC to
As-contaminated well water (As: 27-144&mu;gL-1; n=10) displayed that 92 to
100% of As was depleted despite in the presence of co-occurring competing
anions (e.g., SO42-, CO32-, PO43-). This study shows that OW-BC has a
great potential to remove As from solution and drinking (well) water.
Overall, the combination of macroscopic sorption data and integrated
spectroscopic and microscopic techniques highlight that the fate of As on
biochar involves complex redox transformation and association with surface
functional moieties in aquatic systems, thereby providing crucial
information required for implication of biochar in environmental
remediation programs.
KW - Arsenic contamination
KW - Drinking water, FTIR, remediation
KW - SEM-EDX
KW - Sorbent
KW - Toxicity, XANES
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20171018
STAT- PubMed-not-MEDLINE
DOCNO- medline/29054629

140 - TOXLINE
TI - Assessment of the effect of cooking on speciation and
bioaccessibility/cellular uptake of arsenic in rice, using in vitro
digestion and Caco-2 and PSI cells as model.
AU - Lee SG
AD - Department of Biotechnology, College of Life Sciences and Biotechnology,
Korea University, Seoul 02841, South Korea.
AU - Kim J
AD - Department of Biotechnology, College of Life Sciences and Biotechnology,
Korea University, Seoul 02841, South Korea.
AU - Park H
AD - Graduate School of Advanced Green Energy and Environment, Handong Global
University, Pohang, Gyeongbuk 37554, South Korea.
AU - Holzapfel W
AD - Graduate School of Advanced Green Energy and Environment, Handong Global
University, Pohang, Gyeongbuk 37554, South Korea.
AU - Lee KW
AD - Department of Biotechnology, College of Life Sciences and Biotechnology,
Korea University, Seoul 02841, South Korea. Electronic address:
kwangwon@korea.ac.kr.
SO - Food Chem Toxicol. 2018, Jan; 111:597-604. [Food and chemical toxicology :
an international journal published for the British Industrial Biological
Research Association]
AB - In vitro digestion/Caco-2 or pig small intestinal epithelium cell line
(PSI) uptake models were used to study the bioaccessibility and cellular
uptake of arsenic (As) in cooked white rice and brown rice. The
arsenite(AsIII), was the predominant species in cooked rice and in its
bioaccessible fractions. The percentage of total As bioaccessibility in
white rice (75%) was slightly higher (p=0.061) than that in brown
rice(66%). However, there was no difference in the inorganic As (iAs)
bioaccessibility between white rice (95%) and brown rice (96%). In Caco-2
cell monolayer, total As retention was 7-31%, transport was 4-25%, and
uptake (sum of retention and transport) was 16-38%. In PSI cell model, the
retention, transport, and uptake of tAs were 10-28%, 14-31%, and 29-50%,
respectively. In both cells, the cellular uptake of tAs in brown rice was
1.4-1.5 folds lower (p < 0.05) than that of white rice. These results
indicate that the cellular uptake of As can be affected by nutritional
compositions. These in vitro screening methods can serve as preliminary
screens to predict the relative impact in rice matrix having different As
species and processing conditions, although more research efforts should
be applied to validating the existing in vitro methods.
KW - Bioaccessibility
KW - Cellular uptake
KW - Cooked rice
KW - In vitro digestion/Caco-2 cell model
KW - Inorganic arsenic
RN - N712M78A8G
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180507
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20171206
STAT- MEDLINE
DOCNO- medline/29222053

141 - TOXLINE
TI - Ferroptosis is newly characterized form of neuronal cell death in response
to arsenite exposure.
AU - Tang Q
AD - Department of Occupational and Environmental Health, School of Public Health
and Management, Research Center for Medicine and Social Development, Innovation
Center for Social Risk Governance in Health, Chongqing Medical University,
Chongqing, People's Republic of China.
AU - Bai L
AD - Department of Occupational and Environmental Health, School of Public Health
and Management, Research Center for Medicine and Social Development, Innovation
Center for Social Risk Governance in Health, Chongqing Medical University,
Chongqing, People's Republic of China.
AU - Zou Z
AD - Institute of Life Sciences, Chongqing Medical University, Chongqing, People's
Republic of China.
AU - Meng P
AD - Department of Occupational and Environmental Health, School of Public Health
and Management, Research Center for Medicine and Social Development, Innovation
Center for Social Risk Governance in Health, Chongqing Medical University,
Chongqing, People's Republic of China.
AU - Xia Y
AD - Department of Occupational and Environmental Health, School of Public Health
and Management, Research Center for Medicine and Social Development, Innovation
Center for Social Risk Governance in Health, Chongqing Medical University,
Chongqing, People's Republic of China.
AU - Cheng S
AD - Department of Occupational and Environmental Health, School of Public Health
and Management, Research Center for Medicine and Social Development, Innovation
Center for Social Risk Governance in Health, Chongqing Medical University,
Chongqing, People's Republic of China.
AU - Mu S
AD - Post-doctoral Research Stations of Nursing Science, School of Nursing,
Chongqing Medical University, Chongqing, People's Republic of China.
AU - Zhou J
AD - Post-doctoral Research Stations of Nursing Science, School of Nursing,
Chongqing Medical University, Chongqing, People's Republic of China.
AU - Wang X
AD - Department of Neurology, The First Affiliated Hospital of Chongqing Medical
University, Chongqing Key Laboratory of Neurology, Chongqing, People's Republic of
China.
AU - Qin X
AD - Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical
University, Chongqing, People's Republic of China.
AU - Cao X
AD - Department of Occupational and Environmental Health, School of Public Health
and Management, Research Center for Medicine and Social Development, Innovation
Center for Social Risk Governance in Health, Chongqing Medical University,
Chongqing, People's Republic of China.
AU - Jiang X
AD - Center of Experimental Teaching for Public Health, Experimental Teaching and
Management Center, Chongqing Medical University, Chongqing, People's Republic of
China; Laboratory of Tissue and Cell Biology, Experimental Teaching and Management
Center, Chongqing Medical University, Chongqing, People's Republic of China.
Electronic address: jiangxuejun312@163.com.
AU - Chen C
AD - Department of Occupational and Environmental Health, School of Public Health
and Management, Research Center for Medicine and Social Development, Innovation
Center for Social Risk Governance in Health, Chongqing Medical University,
Chongqing, People's Republic of China; Post-doctoral Research Stations of Nursing
Science, School of Nursing, Chongqing Medical University, Chongqing, People's
Republic of China. Electronic address: chengzhichen@cqmu.edu.cn.
SO - Neurotoxicology. 2018, Apr 17; 67:27-36. [Neurotoxicology]
AB - Ferroptosis is a novel iron-dependent form of cell death implicated in
brain pathology. However, whether arsenite is an inducer of ferroptosis in
the neuron remains completely unknown. In this study, the seven-week-old
healthy C57BL/6&#8239;J male mice were treated with environmental related
doses (0.5, 5 and 50&#8239;mg/L) of arsenite for 6 months via drinking
water, and the ferroptosis-related indicators were further determined. Our
results demonstrated for the first time that, arsenite exposure
significantly reduced the number of neuron and caused the pathological
changes of mitochondria in the cerebral cortex of mice. We further
revealed that arsenite induced ferroptotic cell death in neuron by
accumulation of reactive oxygen species and lipid peroxidation products,
disruption of Fe2+ homeostasis, depletion of glutathione and adenosine
triphosphate, inhibition of cysteine/glutamate antiporter, activation of
mitogen-activated protein kinases and mitochondrial voltage-dependent
anion channels pathways, up-regulation of endoplasmic reticulum stress,
all of which were involved in the process of ferroptosis. These findings
were also verified in the cultured PC-12 cells by using ferropotosis
inhibitor, desferoxamine. Taken together, our results not only reveal a
novel mechanism that chronic arsenite exposure may trigger the new form of
cell death, ferroptosis, but also shed a new light on a potential clue for
the intervention and prevention against arsenite-related neurodegenerative
diseases.
KW - Arsenite
KW - Cell death
KW - Ferroptosis
KW - Mitochondrial dysfunction
KW - ROS
LA - eng
IS - 1872-9711 (Electronic)
PT - Journal Article
TA - Neurotoxicology
YR - 2018
DATE- 20180616
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Neurotoxicology
EDAT- 20180417
STAT- Publisher
DOCNO- medline/29678591

142 - TOXLINE
TI - Thymoquinone alleviates arsenic induced hippocampal toxicity and
mitochondrial dysfunction by modulating mPTP in Wistar rats.
AU - Firdaus F
AD - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India; Department of Zoology, Faculty of Life
Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
AU - Zafeer MF
AD - Interdisciplinary Brain Research Centre, Faculty of Medicine, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
AU - Waseem M
AD - School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and
Technology, Chennai, India.
AU - Ullah R
AD - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University,
Aligarh, Uttar Pradesh, India.
AU - Ahmad M
AD - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim
University, Aligarh, Uttar Pradesh, India.
AU - Afzal M
AD - Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University,
Aligarh, Uttar Pradesh, India. Electronic address: afzalgenetics@gmail.com.
SO - Biomed Pharmacother. 2018, Jun; 102:1152-1160. [Biomedicine &
pharmacotherapy = Biomedecine & pharmacotherapie]
AB - Arsenic is a pervasive environmental pollutant that is found in ground
waters globally and is related to numerous morbidities in the high-risk
population areas in countries including Bangladesh, India, and the USA.
Arsenic exposure has been ubiquitously reported for exacerbating free
radical generation, mitochondrial dysfunction, and apoptosis by
interfering with the mPTP functioning. Over the past decades,
nutraceuticals with antioxidant properties have shown promising efficacy
in arsenic poisoning. In the present study, we have examined, the
protective efficacy of thymoquinone (TQ), an active component of seed oil
of Nigella sativa with antioxidant and anti-inflammatory activity on
arsenic-induced toxicity in hippocampi of Wistar rats. In our results,
arsenic conditioning (10&#8239;mg/kg b.wt.; p.o.) for 8 days has caused a
significant increase in intracellular ROS generation, mitochondrial
dysfunction and apoptotic events. On the contrary pretreatment with TQ
(2.5 and 5&#8239;mg/kg b.wt.; p.o.) inhibited arsenic-induced
mitochondrial dysfunction such as lowering of mitochondrial membrane
potential (&Delta;&psi;m). Our results indicated that the neuroprotective
efficacy of TQ in arsenic-induced stress is mediated through or in part by
inhibition of mPTP opening. Demonstration of neuroprotective action of TQ
provides insight into the pathogenesis of arsenic-related
neuropathological morbidities.
KW - Hippocampus
KW - Membrane potential
KW - Mitochondria
KW - Thymoquinone
KW - mPTP
LA - eng
IS - 1950-6007 (Electronic)
PT - Journal Article
TA - Biomed Pharmacother
YR - 2018
DATE- 20180504
CI - Copyright &copy; 2018 Elsevier Masson SAS. All rights reserved.
CITO- NLM
CS - France
FJT - Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie
EDAT- 20180405
STAT- In-Process
DOCNO- medline/29710533

143 - TOXLINE
TI - Arsenic levels in cutaneous appendicular organs are correlated with
digitally evaluated hyperpigmented skin of the forehead but not the sole
in Bangladesh residents.
AU - Yajima I
AD - Voluntary Body for International Health Care in Universities, 65 Tsurumai-
cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
AU - Ahsan N
AD - Department of Genetic Engineering and Biotechnology, University of Dhaka,
Dhaka 1000, Bangladesh.
AU - Akhand AA
AD - Department of Genetic Engineering and Biotechnology, University of Dhaka,
Dhaka 1000, Bangladesh.
AU - Al Hossain MA
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550,
Japan.
AU - Yoshinaga M
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550,
Japan.
AU - Ohgami N
AD - Voluntary Body for International Health Care in Universities, 65 Tsurumai-
cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
AU - Iida M
AD - Voluntary Body for International Health Care in Universities, 65 Tsurumai-
cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
AU - Oshino R
AD - Voluntary Body for International Health Care in Universities, 65 Tsurumai-
cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
AU - Naito M
AD - Department of Preventive Medicine, Nagoya University Graduate School of
Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
AU - Wakai K
AD - Department of Preventive Medicine, Nagoya University Graduate School of
Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
AU - Kato M
AD - Voluntary Body for International Health Care in Universities, 65 Tsurumai-
cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
SO - J Expo Sci Environ Epidemiol. 2018, Jan; 28(1):64-68. [Journal of exposure
science & environmental epidemiology]
AB - There has been no report showing the effect of arsenic level on digitized
skin pigmentation level, a typical diagnostic marker for arsenicosis.
Correlations among history of drinking well water, arsenic levels in hair
and toenails, and digitalized skin pigmentation levels (L*-value) in
sunlight-exposed (forehead) and unexposed (sole) skin areas digitally
evaluated by using a reflectance spectrophotometer were examined in 150
residents of Bangladesh. Univariate analysis showed that arsenic levels in
hair and toenails of subjects with a history of drinking well water were
10.6-fold and 7.1-fold higher, respectively, than those in subjects
without a history of drinking well water. The mean L*-value of foreheads,
but not that of soles, in subjects with a history of drinking well water
was 1.15-fold lower (more pigmented) than that in subjects without a
history of drinking well water. Significant correlations were found
between duration of drinking well water and arsenic concentrations in hair
(r=0.63; P < 0.01) and toenails (r=0.60; P < 0.01). Multivariate
analysis showed that the arsenic levels in hair and toenails and the
duration of drinking well water were strongly correlated with the
digitized pigmented level of the forehead but not that of the sole. An
increase in the duration of drinking well water may increase
hyperpigmentation in the forehead, but not that in the sole, through an
increased arsenic level in the human body as shown in cutaneous
appendicular organs (hair and toenails).
RN - N712M78A8G
LA - eng
IS - 1559-064X (Electronic)
PT - Comparative Study
PT - Journal Article
TA - J Expo Sci Environ Epidemiol
YR - 2018
DATE- 20180507
CITO- NLM
CS - United States
CSET- IM
FJT - Journal of exposure science &amp; environmental epidemiology
EDAT- 20161214
STAT- MEDLINE
CM - Cites: FASEB J. 2007 Apr;21(4):976-94 (medline /17242160)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 2004;84:1-477 (medline
/15645577)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 1998 Mar;7(3):203-6 (medline
/9521433)
CM - Cites: Environ Health Perspect. 1977 Aug;19:109-19 (medline /908285)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2011 Aug;20(8):1622-8 (medline
/21680533)
CM - Cites: J Korean Med Sci. 2005 Feb;20(1):105-8 (medline /15716613)
CM - Cites: Int J Epidemiol. 1998 Oct;27(5):871-7 (medline /9839746)
CM - Cites: J Health Popul Nutr. 2010 Feb;28(1):14-22 (medline /20214082)
CM - Cites: Arch Toxicol. 2012 Jun;86(6):961-73 (medline /22526373)
CM - Cites: J Invest Dermatol. 2015 Apr;135(4):1147-1156 (medline /25493652)
CM - Cites: PLoS One. 2013 Jun 21;8(6):e66681 (medline /23805262)
CM - Cites: Indian J Community Med. 2010 Apr;35(2):331-8 (medline /20922118)
CM - Cites: Arch Toxicol. 2013 Mar;87(3):439-47 (medline /23100159)
CM - Cites: J Cell Biol. 2004 Apr 26;165(2):275-85 (medline /15117970)
CM - Cites: Pigment Cell Res. 2003 Dec;16(6):629-38 (medline /14629720)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):243-52 (medline
/15276403)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003
Jan;38(1):141-63 (medline /12635824)
CM - Cites: Hum Toxicol. 1983 Jan;2(1):121-33 (medline /6840787)
CM - Cites: Phys Med Biol. 1988 Jun;33(6):711-22 (medline /3406055)
CM - Cites: Mol Cell Biochem. 2005 Nov;279(1-2):105-12 (medline /16283519)
CM - Cites: J Indian Med Assoc. 1998 Jan;96(1):4-7, 18 (medline /9601181)
CM - Cites: J Expo Sci Environ Epidemiol. 2016 Sep;26(5):488-93 (medline
/26464097)
DOCNO- medline/27966667

144 - TOXLINE
TI - Revisiting the biogeochemistry of arsenic in the Baltic Sea: Impact of
anthropogenic activity.
AU - Li L
AD - Key Laboratory of Marine Chemistry Theory and Technology, Ministry of
Education, Ocean University of China, 238 Songling Road, Qingdao 266100, PR China;
Laboratory for Marine Ecology and Environmental Science, Qingdao National
Laboratory for Marine Science and Technology, Qingdao 266071, PR China.
AU - Pohl C
AD - Leibniz-Institute for Baltic Sea Research, Seestra&szlig;e 15, D-18119
Warnem�nde, Germany.
AU - Ren JL
AD - Key Laboratory of Marine Chemistry Theory and Technology, Ministry of
Education, Ocean University of China, 238 Songling Road, Qingdao 266100, PR China;
Laboratory for Marine Ecology and Environmental Science, Qingdao National
Laboratory for Marine Science and Technology, Qingdao 266071, PR China. Electronic
address: renjingl@ouc.edu.cn.
AU - Schulz-Bull D
AD - Leibniz-Institute for Baltic Sea Research, Seestra&szlig;e 15, D-18119
Warnem�nde, Germany.
AU - Cao XH
AD - Key Laboratory of Marine Chemistry Theory and Technology, Ministry of
Education, Ocean University of China, 238 Songling Road, Qingdao 266100, PR China.
AU - Nausch G
AD - Leibniz-Institute for Baltic Sea Research, Seestra&szlig;e 15, D-18119
Warnem�nde, Germany.
AU - Zhang J
AD - State Key Laboratory of Estuarine and Coastal Research, East China Normal
University, 3663 Zhongshan Road North, Shanghai 200062, PR China.
SO - Sci Total Environ. 2018, Feb 01; 613-614:557-568. [The Science of the
total environment]
AB - With the increase in anthropogenic environmental disruption, the behavior
of arsenic in the Baltic Sea has received more scientific attention
because of its complex forms and toxicity, and was re-visited to determine
if there have been measurable changes recently. A cruise was conducted in
10-19 May 2011 to investigate the species and distribution of total
dissolved inorganic arsenic (TDIAs: [TDIAs]=[As(V)]+[As(III)]) revealing
links between the hydrographic dynamics and biological/chemical reactions
in the Baltic Sea. In addition, long-term (2002-2010) time-series
investigations of particulate arsenic in the Gotland Basin were also
conducted in February every year for monitoring purposes. The behavior of
TDIAs was non-conservative due to the removal and regeneration processes
occurring in the Baltic Sea. Biological scavenging plays a dominant role
as sink for TDIAs, with removal amount of 3.1&plusmn;1.6nmol/L above the
pycnocline of the Baltic Sea. Significant regeneration of TDIAs was
observed below the pycnocline of the Baltic Sea, which was closely related
to hypoxia. The decomposition of organic arsenic and release from the
sediment by desorption of As-bearing Fe and Mn oxides were thought to be
two major sources for TDIAs regeneration. The median concentration of
TDIAs (8.4nmol/L) was much lower than in most marginal seas and oceans,
including the near-bottom water around a chemical weapon dumpsite
(13.9nmol/L). The hypoxia in the deep water contributed to the increase in
As(III) concentrations based on the relationship between As(III)/TDIAs
ratio and apparent oxygen utilization. If the difference of As(III)
profiles (1981 and 2011) actually represents a long-term increase in
As(III) concentrations and a shoaling of the As(III) chemocline, these
factors could enhance the toxic effects and extend the residence time of
arsenic and, hence, potentially have negative impacts on fisheries and
ecosystem health in the Baltic Sea.
KW - Arsenic
KW - Baltic Sea
KW - Chemical weapon dump
KW - Hypoxia
KW - Inorganic species
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180319
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20170926
STAT- PubMed-not-MEDLINE
DOCNO- medline/28926810

145 - TOXLINE
TI - Determination of Arsenic Species in Ophiocordyceps sinensis from Major
Habitats in China by HPLC-ICP-MS and the Edible Hazard Assessment.
AU - Guo LX
AD - Dongguan Key Laboratory of Environmental Medicine, School of Public Health,
Guangdong Medical University, Dongguan 523808, China. glx525@gdmu.edu.cn.
AU - Zhang GW
AD - Shenzhen Academy of Metrology and Quality Inspection, Shenzhen 518000, China.
zhguiw98@163.com.
AU - Wang JT
AD - Dongguan Key Laboratory of Environmental Medicine, School of Public Health,
Guangdong Medical University, Dongguan 523808, China. Vivian_jtw@163.com.
AU - Zhong YP
AD - Dongguan Key Laboratory of Environmental Medicine, School of Public Health,
Guangdong Medical University, Dongguan 523808, China. ZYP13415680421@live.com.
AU - Huang ZG
AD - Dongguan Key Laboratory of Environmental Medicine, School of Public Health,
Guangdong Medical University, Dongguan 523808, China. hzg@gdmu.edu.cn.
SO - Molecules. 2018, Apr 26. [Molecules (Basel, Switzerland)]
AB - This study sought to determine the concentration and distribution of
arsenic (As) species in Ophiocordyceps sinensis (O. sinensis), and to
assess its edible hazard for long term consumption. The total arsenic
concentrations, measured through inductively coupled plasma mass
spectrometry (ICP-MS), ranged from 4.00 mg/kg to 5.25 mg/kg. As determined
by HPLC-ICP-MS, the most concerning arsenic species&amp;mdash;AsB, MMAV,
DMAV, AsV, and As&#1064;&amp;mdash;were either not detected (MMAV and
DMAV) or were detected as minor As species (AsB: 1.4&#8315;2.9%; AsV:
1.3&#8315;3.2%, and As&#1064;: 4.1&#8315;6.0%). The major components were
a cluster of unknown organic As (uAs) compounds with As&#1064;, which
accounted for 91.7&#8315;94.0% of the As content. Based on the
H&#8322;O&#8322; test and the chromatography behavior, it can be inferred
that, the uAs might not be toxic organic As. Estimated daily intake (EDI),
hazard quotient (HQ), and cancer risk (CR) caused by the total As content;
the sum of inorganic As (iAs) and uAs, namely i+uAs; and iAs exposure from
long term O. sinensis consumption were calculated and evaluated through
equations from the US Environmental Protection Agency and the
uncertainties were analyzed by Monte-Carlo Simulation (MCS). EDItotal As
and EDIi+uAs are approximately ten times more than EDIiAs; HQtotalAs and
HQi+uAs > 1 while HQiAs < 1; and CRtotal As and CRi+uAs > 1
&amp;times; 10&amp;minus;4 while CRiAs < 1 &amp;times; 10&amp;minus;4.
Thus, if the uAs is non-toxic, there is no particular risk to local
consumers and the carcinogenic risk is acceptable for consumption of O.
sinensis because the concentration of toxic iAs is very low.
KW - HPLC-ICP-MS
KW - Ophiocordyceps sinensis
KW - arsenic speciation
KW - risk assessment
LA - eng
IS - 1420-3049 (Electronic)
PT - Journal Article
TA - Molecules
YR - 2018
DATE- 20180427
CITO- NLM
CS - Switzerland
FJT - Molecules (Basel, Switzerland)
EDAT- 20180426
STAT- In-Process
DOCNO- medline/29701658

146 - TOXLINE
TI - Phosphate starvation response controls genes required to synthesize the
phosphate analog arsenate.
AU - Wang Q
AD - Departments of Land Resources &amp; Environmental Sciences, Montana State
University, Bozeman, MT 59717, USA.
AU - Kang YS
AD - Departments of Land Resources &amp; Environmental Sciences, Montana State
University, Bozeman, MT 59717, USA.
AU - Alowaifeer A
AD - Departments of Land Resources &amp; Environmental Sciences, Montana State
University, Bozeman, MT 59717, USA.
AU - Shi K
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic
of China.
AU - Fan X
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic
of China.
AU - Wang L
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic
of China.
AU - Jetter J
AD - Departments of Land Resources &amp; Environmental Sciences, Montana State
University, Bozeman, MT 59717, USA.
AU - Bothner B
AD - Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
AU - Wang G
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, 430070, People's Republic
of China.
AU - McDermott TR
AD - Departments of Land Resources &amp; Environmental Sciences, Montana State
University, Bozeman, MT 59717, USA.
SO - Environ Microbiol. 2018, May; 20(5):1782-1793. [Environmental
microbiology]
AB - Environmental arsenic poisoning affects roughly 200 million people
worldwide. The toxicity and mobility of arsenic in the environment is
significantly influenced by microbial redox reactions, with arsenite
(AsIII ) being more toxic than arsenate (AsV ). Microbial oxidation of
AsIII to AsV is known to be regulated by the AioXSR signal transduction
system and viewed to function for detoxification or energy generation.
Here, we show that AsIII oxidation is ultimately regulated by the
phosphate starvation response (PSR), requiring the sensor kinase PhoR for
expression of the AsIII oxidase structural genes aioBA. The PhoRB and
AioSR signal transduction systems are capable of transphosphorylation
cross-talk, closely integrating AsIII oxidation with the PSR. Further,
under PSR conditions, AsV significantly extends bacterial growth and
accumulates in the lipid fraction to the apparent exclusion of phosphorus.
This could spare phosphorus for nucleic acid synthesis or triphosphate
metabolism wherein unstable arsenic esters are not tolerated, thereby
enhancing cell survival potential. We conclude that AsIII oxidation is
logically part of the bacterial PSR, enabling the synthesis of the
phosphate analog AsV to replace phosphorus in specific biomolecules or to
synthesize other molecules capable of a similar function, although not for
total replacement of cellular phosphate.
LA - eng
IS - 1462-2920 (Electronic)
PT - Journal Article
TA - Environ Microbiol
YR - 2018
DATE- 20180426
CI - &copy; 2018 Society for Applied Microbiology and John Wiley &amp; Sons
Ltd.
CITO- NLM
CS - England
FJT - Environmental microbiology
EDAT- 20180410
STAT- In-Data-Review
DOCNO- medline/29575522

147 - TOXLINE
TI - Ellagic acid: A promising protective remedy against testicular toxicity
induced by arsenic.
AU - Mehrzadi S
AD - Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
AU - Bahrami N
AD - Department of Midwifery, Faculty of Nursing and Midwifery, Dezful University
of Medical Sciences, Dezful, Iran.
AU - Mehrabani M
AD - Physiology Research Center, Institute of Basic and Clinical Physiology
Sciences, Kerman University of Medical Sciences, Kerman, Iran.
AU - Motevalian M
AD - Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
AU - Mansouri E
AD - Cellular and Molecular Research Center, Department of Anatomical Sciences,
Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AU - Goudarzi M
AD - Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical
Sciences, Ahvaz, Iran. Electronic address: Mehrzadi.s@iums.ac.ir.
SO - Biomed Pharmacother. 2018, Jul; 103:1464-1472. [Biomedicine &
pharmacotherapy = Biomedecine & pharmacotherapie]
AB - Chronic exposure to arsenic, an inducer of oxidative stress, is one of the
major causes of male infertility. Therefore, the present study
investigated the protective role of Ellagic acid (EA), as a natural
antioxidant, against testicular toxicity evoked by arsenic. Thirty-five
male Wistar rats were divided into 5 treatment groups. Group 1 served as
control, group 2 were orally exposed to sodium arsenite (SA,
10&#8239;mg/kg; 21 days), groups 3 and 4 were initially exposed to SA for
7 days and then were treated with both EA (10 and 30&#8239;mg/kg) and SA
up to 21 days, and group 5 was treated with EA for 14 days. After this
period, biochemical and histopathological parameters were evaluated in
serum samples and testicular tissue. SA markedly reduced levels of serum
testosterone, total antioxidant capacity, reduced glutathione as well as
the activity of antioxidant enzymes. Furthermore, SA enhanced levels of
malondialdehyde, tumor necrosis factor-&alpha;, interleukin-1&beta; and
nitric oxide in testes. Treatment with EA was found to reduce testicular
arsenic accumulation and oxidative stress parameters. In addition, EA
improved the serum testosterone level, testicular antioxidant markers and
histological parameters after exposure to SA. EA may emerge as a promising
therapeutic option to protect testes from arsenic-induced toxicity through
reducing oxidative stress and inflammatory responses.
KW - Arsenic
KW - Ellagic acid
KW - Male infertility
KW - Oxidative stress
KW - Rat
KW - Testes
LA - eng
IS - 1950-6007 (Electronic)
PT - Journal Article
TA - Biomed Pharmacother
YR - 2018
DATE- 20180605
CI - Copyright &copy; 2018 Elsevier Masson SAS. All rights reserved.
CITO- NLM
CS - France
FJT - Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie
EDAT- 20180507
STAT- In-Process
DOCNO- medline/29864931

148 - TOXLINE
TI - Rapid evaluation of arsenic contamination in paddy soils using field
portable X-ray fluorescence spectrometry.
AU - Liang JH
AD - Key Laboratory of Karst Ecosystem and Treatment of Rocky Desertification,
Institute of Karst Geology, Chinese Academy of Geological Sciences, Guilin 541004,
China; State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
AU - Liu PP
AD - State Key Joint Laboratory of Environment Simulation and Pollution Control,
School of Environment, Tsinghua University, Beijing 100084, China; State Key
Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental
Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
AU - Chen Z
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China;
Department of Environmental Science, Xi'an Jiaotong-Liverpool University, Suzhou
215123, China. Electronic address: zheng.chen@xjtlu.edu.cn.
AU - Sun GX
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
AU - Li H
AD - College of Urban Construction and Environmental Engineering, Chongqing
University, Chongqing 400045, China.
SO - J Environ Sci (China). 2018, Feb; 64:345-351. [Journal of environmental
sciences (China)]
AB - Arsenic (As) in paddy fields is deteriorating food security and human
health through rice ingestion. Rice is the dominant food source of arsenic
exposure to half of the world's population. Therefore, an in situ
effective method for As risk evaluation in paddy soil is strongly needed
to avoid As exposure through rice ingestion. Herein, we developed a rapid
analytical methodology for determination of As in plant tissues using
field portable X-ray fluorescence spectrometry (FP-XRF). This method was
applied to rice roots in order to evaluate the As contamination in paddy
soils. The results showed that rice roots with iron plaques were superior
to rhizosphere soils for generating FP-XRF signals, especially for field
sites with As concentrations lower than the soil detection limit of FP-XRF
(30.0mg/kg). Moreover, the strong linear relationships of As
concentrations between the rice roots and corresponding leaves and grains
proved that the rice root, rather than the soil, is a better predictor of
As concentrations in rice grains. The research provides an efficient As
monitoring method for As contaminated paddy fields by using wetland plant
roots with iron plaques and XRF-based analytical techniques.
KW - Arsenic
KW - Iron plaque
KW - Rhizosphere soils
KW - Rice roots
KW - Risk evaluation
KW - XRF
RN - N712M78A8G
LA - eng
IS - 1001-0742 (Print)
PT - Journal Article
TA - J Environ Sci (China)
YR - 2018
DATE- 20180301
CI - Copyright &copy; 2017. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Journal of environmental sciences (China)
EDAT- 20171124
STAT- MEDLINE
DOCNO- medline/29478657

149 - TOXLINE
TI - Toxicity assessment of arsenate and arsenite on growth, chlorophyll a
fluorescence and antioxidant machinery in Nostoc muscorum.
AU - Patel A
AD - Ranjan Plant physiology and Biochemistry Laboratory, Department of Botany,
University of Allahabad, Allahabad 211002, India.
AU - Tiwari S
AD - Ranjan Plant physiology and Biochemistry Laboratory, Department of Botany,
University of Allahabad, Allahabad 211002, India.
AU - Prasad SM
AD - Ranjan Plant physiology and Biochemistry Laboratory, Department of Botany,
University of Allahabad, Allahabad 211002, India. Electronic address:
profsmprasad@gmail.com.
SO - Ecotoxicol Environ Saf. 2018, Aug 15; 157:369-379. [Ecotoxicology and
environmental safety]
AB - The present study deals with impact of varied doses of arsenite (AsIII;
50, 100 and 150&#8239;&micro;M) and arsenate (AsV; 50, 100 and
150&#8239;mM) on growth, photosynthetic pigments, photochemistry of
photosystem II, oxidative biomarkers, (O2&bull;&macr;, H2O2 and MDA
equivalents contents) and activity of antioxidant enzymes in diazotrophic
cyanobacterium Nostoc muscorum after 48 and 96&#8239;h of the treatments.
The reduction in growth, pigment contents (Chl a, Phy and Car) and PS II
photochemistry was found to increase with enhanced accumulation of test
metal in cells, and the damaging effect on photosynthetic pigments showed
the order (Phy > chl a > Car). The negative effect on PS II
photochemistry was due to significant decrease in the value of JIP
kinetics &#981;P0, FV/F0, &#981;E0,&Psi;0 and PIABS except F0/FV and
significant rise in values of energy flux parameters such as ABS/RC,
TR0/RC, ET0/RC and DI0/RC. Both the species of arsenic caused significant
rise in oxidative biomarkers as evident by in vitro and in vivo analysis
of (O2&bull;&macr;, H2O2 and MDA equivalents contents) despite of
appreciable rise in the activity antioxidative enzymes such as SOD, POD,
CAT and GST. The study concludes that in among both forms of arsenic,
arsenite effect was more dominant on growth, photosynthetic pigments;
oxidative stress biomarkers as evident by weak induction of anti-oxidative
defense system to overcome the stress as compared to arsenate.
KW - Antioxidant defense system
KW - Arsenic accumulation
KW - Growth
KW - Isoenzyme profiling
KW - Oxidative biomarkers
KW - PS II photochemistry
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180424
CI - Published by Elsevier Inc.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180406
STAT- In-Process
DOCNO- medline/29631092

150 - TOXLINE
TI - Geographical variations of cadmium and arsenic concentrations and arsenic
speciation in Chinese rice.
AU - Chen H
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing,
210095, China.
AU - Tang Z
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing,
210095, China.
AU - Wang P
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing,
210095, China.
AU - Zhao FJ
AD - State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of
Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing,
210095, China. Electronic address: Fangjie.Zhao@njau.edu.cn.
SO - Environ Pollut. 2018, Jul; 238:482-490. [Environmental pollution (Barking,
Essex : 1987)]
AB - Rapid industrialization in China in recent decades has resulted in soil
contamination in some areas, raising the concern about food safety.
Consumption of rice represents a major exposure route for the toxic
elements cadmium (Cd) and arsenic (As). We collected 160 polished rice
from local markets in 20 provinces in China and determined total Cd and As
concentrations and As speciation. Total Cd concentration ranged from below
the detection limit to 0.77&#8239;mg&#8239;kg-1, with 10% of the samples
exceeding the Chinese limit (0.2&#8239;mg&#8239;kg-1). Rice Cd
concentration showed a distinct geographical pattern, increasing from low
levels in the north to high levels in the south of China. Median daily Cd
intake from rice varied from 0.01&#8239;&mu;g&#8239;kg-1 body weight in
the north to 0.61&#8239;&mu;g&#8239;kg-1 body weight in the south of
China, representing between 1% and 73% of the tolerable daily intake (TDI)
recommended by FAO/WHO. The highest median Cd intake from rice was in
Hunan province with 2 times TDI. Total As concentration ranged from 0.011
to 0.186&#8239;mg&#8239;kg-1, with inorganic As (iAs) and dimethylarsinic
acid (DMAs) on average accounting for 69% and 31%, respectively. All
samples were below the Chinese limit for iAs in rice
(0.2&#8239;mg&#8239;kg-1). There was no clear geographical pattern in rice
total As concentration, but rice produced in northeastern China contained
higher percentages of DMAs and lower percentages of iAs. This study
highlights a high risk of Cd exposure from rice consumption for the
population of southern China and suggested strategies for reducing Cd
accumulation in rice crop.
KW - Arsenic
KW - Arsenic speciation
KW - Cadmium
KW - Dietary intake
KW - Rice
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180515
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180330
STAT- In-Process
DOCNO- medline/29602104

151 - TOXLINE
TI - Arsenate biotransformation by Microcystis aeruginosa under different
nitrogen and phosphorus levels.
AU - Che F
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:
cheff411@sina.com.
AU - Du M
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China.
AU - Yan C
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:
czyan@iue.ac.cn.
SO - J Environ Sci (China). 2018, Apr; 66:41-49. [Journal of environmental
sciences (China)]
AB - The arsenate (As(V)) biotransformation by Microcystis aeruginosa in a
medium with different concentrations of nitrogen (N) and phosphorus (P)
has been studied under laboratory conditions. When 15&mu;g/L As(V) was
added, N and P in the medium showed effective regulation on arsenic (As)
metabolism in M. aeruginosa, resulting in significant differences in the
algal growth among different N and P treatments. Under 0.2mg/L P
treatment, increases in N concentration (4-20mg/L) significantly
stimulated the cell growth and therefore indirectly enhanced the
production of dimethylarsinic acid (DMA), the main As metabolite,
accounting for 71%-79% of the total As in the medium. Meanwhile, 10-20mg/L
N treatments accelerated the ability of As metabolization by M.
aeruginosa, leading to higher contents of DMA per cell. However, As(V)
uptake by M. aeruginosa was significantly impeded by 0.5-1.0mg/L P
treatment, resulting in smaller rates of As transformation in M.
aeruginosa as well as lower contents of As metabolites in the medium. Our
data demonstrated that As(V) transformation by M. aeruginosa was
significantly accelerated by increasing N levels, while it was inhibited
by increasing P levels. Overall, both P and N play key roles in As(V)
biotransformation processes.
KW - Arsenate
KW - Biotransformation
KW - M. aeruginosa
KW - Nitrogen
KW - Phosphorus
RN - 27YLU75U4W
RN - N762921K75
LA - eng
IS - 1001-0742 (Print)
PT - Journal Article
TA - J Environ Sci (China)
YR - 2018
DATE- 20180419
CI - Copyright &copy; 2017. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Journal of environmental sciences (China)
EDAT- 20170607
STAT- MEDLINE
DOCNO- medline/29628107

152 - TOXLINE
TI - Cellular shear stiffness reflects progression of arsenic-induced
transformation during G1.
AU - Mu�oz A
AD - Centre for Symmetry and Deformation, Department of Mathematical Sciences,
University of Copenhagen, Copenhagen &Oslash;, Denmark.
AU - Eldridge WJ
AD - Department of Biomedical Engineering, Duke University, Durham, NC, USA.
AU - Jakobsen NM
AD - Department of Applied Mathematics and Computer Science, Technical University
of Denmark, Lyngby, Denmark.
AU - S�rensen H
AD - Laboratory for Applied Statistics, Department of Mathematical Sciences,
University of Copenhagen, Copenhagen &Oslash;, Denmark.
AU - Wax A
AD - Department of Biomedical Engineering, Duke University, Durham, NC, USA.
AU - Costa M
AD - Department of Environmental Medicine, New York University School of Medicine,
Tuxedo, NY, USA.
SO - Carcinogenesis. 2018, Feb 09; 39(2):109-117. [Carcinogenesis]
AB - Cancer cells consistently exhibit decreased stiffness; however, the onset
and progression of this change have not been characterized. To study the
development of cell stiffness changes, we evaluated the shear stiffness of
populations of cells during transformation to a carcinogenic state.
Bronchial epithelial cells were exposed to sodium arsenite to initiate
early stages of transformation. Exposed cells were cultured in soft agar
to further transformation and select for clonal populations exhibiting
anchorage-independent growth. Shear stiffness of various cell populations
in G1 was assessed using a novel non-invasive assay that applies shear
stress with fluid flow and evaluates nanoscale deformation using
quantitative phase imaging (QPI). Arsenic-treated cells exhibited reduced
stiffness relative to control cells, while arsenic clonal lines, selected
by growth in soft agar, were found to have reduced stiffness relative to
control clonal lines, which were cultured in soft agar but did not receive
arsenic treatment. The relative standard deviation (RSD) of the stiffness
of Arsenic clones was reduced compared with control clones, as well as to
the arsenic-exposed cell population. Cell stiffness at the population
level exhibits potential to be a novel and sensitive framework for
identifying the development of cancerous cells.
LA - eng
IS - 1460-2180 (Electronic)
PT - Journal Article
TA - Carcinogenesis
YR - 2018
DATE- 20180330
CI - &copy; The Author(s) 2017. Published by Oxford University Press. All
rights reserved. For Permissions, please email:
journals.permissions@oup.com.
CITO- NLM
CS - England
FJT - Carcinogenesis
STAT- In-Data-Review
CM - Cites: Science. 2005 Nov 18;310(5751):1139-43 (medline /16293750)
CM - Cites: Opt Lett. 2016 Jan 15;41(2):352-5 (medline /26766712)
CM - Cites: Environ Health Perspect. 2010 Jan;118(1):108-15 (medline /20056578)
CM - Cites: Biochem Biophys Res Commun. 2008 Oct 3;374(4):609-13 (medline
/18656442)
CM - Cites: J Biomed Opt. 2010 Jan-Feb;15(1):010505 (medline /20210420)
CM - Cites: J Natl Cancer Inst. 2010 May 5;102(9):638-49 (medline /20339138)
CM - Cites: Environ Health Perspect. 2011 Jan;119(1):11-9 (medline /20682481)
CM - Cites: J Expo Sci Environ Epidemiol. 2006 Mar;16(2):191-205 (medline
/16160703)
CM - Cites: Exp Cell Res. 1971 Sep;68(1):163-8 (medline /5165443)
CM - Cites: Environ Health Perspect. 2008 Feb;116(2):158-64 (medline /18288312)
CM - Cites: Nat Rev Cancer. 2009 Feb;9(2):108-22 (medline /19165226)
CM - Cites: Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Oct;92(4):040702
(medline /26565151)
CM - Cites: Cell. 2011 Mar 4;144(5):646-74 (medline /21376230)
CM - Cites: Br J Cancer. 2012 Jul 10;107(2):224-9 (medline /22691969)
CM - Cites: Free Radic Biol Med. 2011 Jul 15;51(2):257-81 (medline /21554949)
CM - Cites: Toxicol Sci. 2007 Jul;98(1):75-86 (medline /17283378)
CM - Cites: Curr Opin Cell Biol. 2010 Oct;22(5):697-706 (medline /20822891)
CM - Cites: Biomed Opt Express. 2012 May 1;3(5):958-65 (medline /22567588)
CM - Cites: FASEB J. 2006 May;20(7):811-27 (medline /16675838)
CM - Cites: Cancer Res. 2011 Aug 1;71(15):5075-80 (medline /21642375)
CM - Cites: Cancer Res. 2009 Mar 1;69(5):1728-32 (medline /19223529)
CM - Cites: Cancer Res. 1978 Oct;38(10):3174-81 (medline /210930)
CM - Cites: Annu Rev Public Health. 2012 Apr;33:137-56 (medline /22224878)
CM - Cites: J Biomed Opt. 2011 Mar;16(3):030506 (medline /21456860)
CM - Cites: Environ Health Perspect. 2013 Jul;121(7):832-8 (medline /23665672)
CM - Cites: Metallomics. 2013 Oct;5(10):1357-67 (medline /23963610)
CM - Cites: PLoS One. 2011 Mar 18;6(3):e17982 (medline /21437242)
CM - Cites: Biophys J. 2005 May;88(5):3689-98 (medline /15722433)
CM - Cites: Environ Geochem Health. 2009 Apr;31 Suppl 1:189-200 (medline
/19190988)
CM - Cites: Analyst. 2008 Nov;133(11):1498-500 (medline /18936825)
CM - Cites: Exp Cell Res. 2002 Aug 1;278(1):92-100 (medline /12126961)
CM - Cites: Nat Methods. 2015 Mar;12(3):199-202, 4 p following 202 (medline
/25643151)
CM - Cites: Acta Biomater. 2007 Jul;3(4):413-38 (medline /17540628)
CM - Cites: Cancer Cell. 2005 Sep;8(3):241-54 (medline /16169468)
CM - Cites: Eur Biophys J. 1999;28(4):312-6 (medline /10394623)
CM - Cites: Cancer Res. 2016 Jun 1;76(11):3136-44 (medline /27009166)
CM - Cites: Clin Cancer Res. 2015 Jul 1;21(13):2916-23 (medline /25838394)
CM - Cites: Environ Health Perspect. 2006 Aug;114(8):1193-8 (medline /16882524)
CM - Cites: J Cell Sci. 2003 Apr 1;116(Pt 7):1157-73 (medline /12615960)
CM - Cites: Biochim Biophys Acta. 2012 Jul;1820(7):1111-20 (medline /22366469)
CM - Cites: Biomed Opt Express. 2010 Aug 23;1(2):706-719 (medline /21258502)
CM - Cites: Nat Rev Cancer. 2015 Aug;15(8):473-83 (medline /26156638)
CM - Cites: Trends Mol Med. 2012 Sep;18(9):509-15 (medline /22795735)
CM - Cites: Nanotechnology. 2008 Sep 24;19(38):384003 (medline /21832563)
CM - Cites: Science. 1977 Aug 26;197(4306):893-5 (medline /887927)
CM - Cites: Mt Sinai J Med. 2004 Nov;71(6):361-7 (medline /15592654)
CM - Cites: Nat Rev Mol Cell Biol. 2011 May;12(5):308-19 (medline /21508987)
DOCNO- medline/29069374

153 - TOXLINE
TI - ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of
Arsenite-Induced Stress Granules.
AU - Turakhiya A
AD - Department of Biochemistry, Biocenter, University of W�rzburg, 97074
W�rzburg, Germany.
AU - Meyer SR
AD - Department of Biochemistry, Biocenter, University of W�rzburg, 97074
W�rzburg, Germany.
AU - Marincola G
AD - Department of Biochemistry, Biocenter, University of W�rzburg, 97074
W�rzburg, Germany.
AU - B�hm S
AD - Department of Biochemistry, Biocenter, University of W�rzburg, 97074
W�rzburg, Germany.
AU - Vanselow JT
AD - Rudolf Virchow Center for Experimental Biomedicine, University of W�rzburg,
97080 W�rzburg, Germany.
AU - Schlosser A
AD - Rudolf Virchow Center for Experimental Biomedicine, University of W�rzburg,
97080 W�rzburg, Germany.
AU - Hofmann K
AD - Institute for Genetics, University of Cologne, 50674 Cologne, Germany.
AU - Buchberger A
AD - Department of Biochemistry, Biocenter, University of W�rzburg, 97074
W�rzburg, Germany. Electronic address: alexander.buchberger@uni-wuerzburg.de.
SO - Mol Cell. 2018, Jun 07; 70(5):906-919.e7. [Molecular cell]
AB - Stress granules (SGs) are cytoplasmic assemblies of mRNPs stalled in
translation initiation. They are induced by various stress conditions,
including exposure to the environmental toxin and carcinogen arsenic.
While perturbed SG turnover is linked to the pathogenesis of
neurodegenerative diseases, the molecular mechanisms underlying SG
formation and turnover are still poorly understood. Here, we show that
ZFAND1 is an evolutionarily conserved regulator of SG clearance. ZFAND1
interacts with two key factors of protein degradation, the 26S proteasome
and the ubiquitin-selective segregase p97, and recruits them to
arsenite-induced SGs. In the absence of ZFAND1, SGs lack the 26S
proteasome and p97, accumulate defective ribosomal products, and persist
after arsenite removal, indicating their transformation into aberrant,
disease-linked SGs. Accordingly, ZFAND1 depletion is epistatic to the
expression of pathogenic mutant p97 with respect to SG clearance,
suggesting that ZFAND1 function is relevant to the multisystem
degenerative disorder IBMPFD/ALS.
KW - Cdc48
KW - DRiPs
KW - UPS
KW - VCP
KW - arsenic
KW - autophagy
KW - proteasome
KW - proteostasis
KW - stress granules
LA - eng
IS - 1097-4164 (Electronic)
PT - Journal Article
TA - Mol Cell
YR - 2018
DATE- 20180608
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Molecular cell
EDAT- 20180524
STAT- In-Data-Review
DOCNO- medline/29804830

154 - TOXLINE
TI - Effects of Combined Exposure to Chronic High-Fat Diet and Arsenic on
Thyroid Function and Lipid Profile in Male Mouse.
AU - Ahangarpour A
AD - Health Research Institute, Diabetes Research Center, Department of
Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AU - Alboghobeish S
AD - Department of Pharmacology, School of Medicine, Student Research Committee of
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
alboghobeish.s@ajums.ac.ir.
AU - Oroojan AA
AD - Department of Physiology, Student Research Committee of Ahvaz Jundishapur
University of Medical Science, Ahvaz, Iran.
AU - Zeidooni L
AD - Department of Toxicology, School of Pharmacy, Student Research Committee of
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AU - Samimi A
AD - Department of Toxicology, School of Pharmacy, Student Research Committee of
Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AU - Afshari G
AD - Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur
University of Medical Sciences, Ahvaz, Iran.
SO - Biol Trace Elem Res. 2018, Mar; 182(1):37-48. [Biological trace element
research]
AB - The thyroid is one of the major endocrine glands that contribute to body
and fat metabolism. The present study evaluated the effects of combined
exposure to chronic high-fat diet (HFD) and arsenic on thyroid function
and lipid profile. In this experimental study, 72 male Naval Medical
Research Institute mice were divided into six groups and fed HFD or
low-fat diet (LFD) while being exposed to 25 or 50 ppm of arsenic in
drinking water for 20 weeks. After 24 h of the last experimental
day, blood samples were collected for hormonal and biochemical
measurements. The data indicated that exposure to HFD alone increased the
levels of triiodothyronine (T3), thyroid-stimulating hormone (TSH),
leptin, lipid profile, reactive oxygen species (ROS), and malondialdehyde
(MDA) and decreased the levels of high-density lipoprotein, albumin,
adiponectin, and glutathione sulfhydryl reductase (GSH), whereas exposure
to arsenic alone decreased the levels of T3 and GSH and increased the
levels of TSH, leptin, ROS, MDA, and T4/T3 ratio compared to those in the
control LFD group. Furthermore, concomitant administration of HFD and
arsenic decreased the lipid profile and levels of T4, albumin, total
protein, T3, and GSH and increased the levels of TSH, adiponectin, leptin,
ROS, MDA, and T4/T3 ratio compared to those in the control LFD or HFD
group. In conclusion, combined exposure to HFD and arsenic induced
hypothyroidism via reduction of thyroid hormones and enhancement of plasma
TSH and T3 uptake levels concomitant with hypolipidemia, hyperleptinemia,
hyperadiponectinemia, induction of oxidative stress, and reduction of GSH
levels.
KW - Arsenic
KW - High-fat diet
KW - Lipid profile
KW - Oxidant/antioxidant
KW - Thyroid hormone
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180211
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170608
STAT- In-Process
DOCNO- medline/28593471

155 - TOXLINE
TI - Preconcentration and speciation of arsenic by using a graphene oxide
nanoconstruct functionalized with a hyperbranched polyethyleneimine.
AU - Ahmad H
AD - Centre for Nanoscience and Nanotechnology, Jamia Millia Islamia (A Central
University), New Delhi, 110025, India. hilalahmad418@gmail.com.
AU - Umar K
AD - Centre for Environmental Sustainability and Water Security (IPASA), Research
Institute for Sustainable Environment, Universiti Teknologi Malaysia, 81310, Johor
Bahru, Johor, Malaysia.
AU - Ali SG
AD - Department of Microbiology, Nanotechnology and Antimicrobial Drug Resistance
Research Laboratory, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim
University, Aligarh, Uttar Pradesh, 202001, India.
AU - Singh P
AD - Centre for Nanoscience and Nanotechnology, Jamia Millia Islamia (A Central
University), New Delhi, 110025, India.
AU - Islam SS
AD - Centre for Nanoscience and Nanotechnology, Jamia Millia Islamia (A Central
University), New Delhi, 110025, India.
AU - Khan HM
AD - Department of Microbiology, Nanotechnology and Antimicrobial Drug Resistance
Research Laboratory, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim
University, Aligarh, Uttar Pradesh, 202001, India.
SO - Mikrochim Acta. 2018, May 10; 185(6):290. [Mikrochimica acta]
AB - A column sorbent for arsenic was obtained through immobilization of highly
branched polyethylenimine (PEI) on graphene oxide (GO). The composite
material enables speciation of arsenic by tuning the pH of the sample
solution which governs the surface charge of the sorbent, depending on
whether amino groups (-NH2) are present (at high pH) or ammonium groups
(-NH3+; at low pH). The composite can be applied to improved speciation of
arsenic (compared to unmodified GO). There is no need for oxidation or
reduction of arsenic. A column procedure was applied for the sequestered
extraction and speciation of As(III) and As(V) from environmental water
samples before their determination by hydride generation-microwave induced
plasma-atomic emission spectrometry. The method has a preconcentration
factor of 440 for As(III) and of 400 for As(V). The limits of detection
(at 3 S/N) are extremely low, being 1.8 &plusmn;&thinsp;0.2
ngL-1 for As(III) and 1.3 &plusmn;&thinsp;0.08 ngL-1 for As(V). This
is much lower than the arsenic guideline value of 10 &mu;gL-1 as given by
the WHO. Graphical abstract Graphene oxide interconnected with
polyethyleneimine has been employed for the speciation and determination
of arsenic. Quantitation by atomic emission spectroscopy reveals a high
preconcentration factor (440 and 400) and low LODs of
1.8&thinsp;&plusmn;&thinsp;0.2 and 1.3&thinsp;&plusmn;&thinsp;0.08
ngL-1for As(III) and As(V), respectively.
KW - Adsorption
KW - Nanosorbent
KW - Remediation
KW - Removal
KW - Selectivity
KW - Solid phase extraction
KW - Toxicity
KW - Wastewater
LA - eng
IS - 1436-5073 (Electronic)
PT - Journal Article
TA - Mikrochim Acta
YR - 2018
DATE- 20180514
CITO- NLM
CS - Austria
FJT - Mikrochimica acta
EDAT- 20180510
STAT- In-Data-Review
CM - Cites: Science. 2013 Aug 23;341(6148):866-8 (medline /23970694)
CM - Cites: Anal Chim Acta. 2014 Jun 27;834:22-9 (medline /24928241)
CM - Cites: ACS Appl Mater Interfaces. 2014 Aug 13;6(15):13257-65 (medline
/25003835)
CM - Cites: Anal Chem. 2015 Aug 18;87(16):8503-9 (medline /26211572)
CM - Cites: ACS Appl Mater Interfaces. 2013 Apr 24;5(8):3304-11 (medline
/23528072)
CM - Cites: Science. 2002 Jun 21;296(5576):2143-5 (medline /12077387)
CM - Cites: Chem Commun (Camb). 2013 Aug 14;49(63):7064-6 (medline /23817554)
CM - Cites: Anal Chem. 2016 Jan 5;88(1):228-49 (medline /26616153)
CM - Cites: Chem Soc Rev. 2015 Aug 21;44(16):5861-96 (medline /25812036)
DOCNO- medline/29748777

156 - TOXLINE
TI - Experimental manipulation of dietary arsenic levels in great tit
nestlings: Accumulation pattern and effects on growth, survival and plasma
biochemistry.
AU - S�nchez-Virosta P
AD - Department of Biology, University of Turku, Turku FI-20014, Finland; Area of
Toxicology, Department of Socio-Sanitary Sciences, University of Murcia, Campus de
Espinardo, 30100 Murcia, Spain. Electronic address: pasanv@utu.fi.
AU - Esp�n S
AD - Department of Biology, University of Turku, Turku FI-20014, Finland; Area of
Toxicology, Department of Socio-Sanitary Sciences, University of Murcia, Campus de
Espinardo, 30100 Murcia, Spain. Electronic address: sieslu@utu.fi.
AU - Ruiz S
AD - Department of Biology, University of Turku, Turku FI-20014, Finland.
Electronic address: srruiz@utu.fi.
AU - Salminen JP
AD - Laboratory of Organic Chemistry and Chemical Biology, Department of
Chemistry, University of Turku, Turku FI-20014, Finland. Electronic address: j-
p.salminen@utu.fi.
AU - Garc�a-Fern�ndez AJ
AD - Area of Toxicology, Department of Socio-Sanitary Sciences, University of
Murcia, Campus de Espinardo, 30100 Murcia, Spain. Electronic address: ajgf@um.es.
AU - Eeva T
AD - Department of Biology, University of Turku, Turku FI-20014, Finland.
Electronic address: teeva@utu.fi.
SO - Environ Pollut. 2018, Feb; 233:764-773. [Environmental pollution (Barking,
Essex : 1987)]
AB - Arsenic (As) is a ubiquitous metalloid classified as one of the most
hazardous substances, but information about its exposure and effects in
free-living passerines is lacking. The aim of this study is to elucidate
the effect of an As manipulation experiment on survival, growth and
physiology of great tits (Parus major). Wild P. major nestlings
inhabiting an unpolluted area were dosed with water, 0.2 or
1 &mu;g g-1 d-1 of sodium arsenite (Control, Low and High
As groups), whereas those living in a metal-polluted area were dosed with
water (Smelter group). Birds accumulated As in tissues (liver, bone and
feathers) in a dose-dependent way. Nestlings exposed to
1 &mu;g g-1 d-1 of sodium arsenite showed reduced number of
fledglings per successful nest, and those exposed to
0.2 &mu;g g-1 d-1 had reduced wing growth, which could have
post-fledging consequences such as increased predation risk. These results
suggest that the LOAEL for effects on nestling survival and development in
great tits is likely equal to or below 1 &mu;g g-1 d-1.
However, limited effects on the biochemical parameters evaluated were
found. It has been shown that As may produce oxidative stress and tissue
damage, so further research exploring this issue will be carried out in a
future study.
KW - Breeding success
KW - Insectivorous passerines
KW - Parus major
KW - Pollution
KW - Vitamins
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180411
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171108
STAT- MEDLINE
DOCNO- medline/29127934

157 - TOXLINE
TI - 3,4-Dihydroxybenzaldehyde lowers ROS generation and protects human red
blood cells from arsenic(III) induced oxidative damage.
AU - Maheshwari N
AD - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim
University, Aligarh, Uttar Pradesh, 202002, India.
AU - Khan FH
AD - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim
University, Aligarh, Uttar Pradesh, 202002, India.
AU - Mahmood R
AD - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim
University, Aligarh, Uttar Pradesh, 202002, India.
SO - Environ Toxicol. 2018, May 06. [Environmental toxicology]
AB - Arsenic (As) is a potent environmental toxicant and chronic exposure to it
results in various malignancies in humans. Oxidative stress has been
implicated in the etiopathogenesis of As-induced toxicity. This
investigated the protective effect of plant antioxidant
3,4-dihydroxybenzaldehyde (DHB) on sodium meta-arsenite (SA), an As-(III)
compound, induced oxidative damage in human red blood cells (RBC). The RBC
were first incubated with different concentrations of DHB and then treated
with SA at 37&deg;C. Hemolysates were prepared and assayed for various
biochemical parameters. Treatment of RBC with SA alone enhanced the
generation of reactive oxygen species and increased lipid and protein
oxidation. Reduced glutathione levels, total sulfhydryl content and
cellular antioxidant power were significantly decreased in SA alone
treated RBC, compared to the untreated control cells. This was accompanied
by membrane damage, alterations in activities of antioxidant enzymes and
deranged glucose metabolism. Incubation of RBC with DHB, prior to
treatment with SA, significantly and dose-dependently attenuated the
SA-induced changes in all these parameters. Scanning electron microscopy
of RBC confirmed these biochemical results. Treatment of RBC with SA alone
converted the biconcave discoids to echinocytes but the presence of DHB
inhibited this conversion and the RBC retained their normal shape. These
results show that DHB protects human RBC from SA-induced oxidative damage,
most probably due to its antioxidant character.
KW - 3,4-dihydroxybenzaldehyde
KW - antioxidant
KW - arsenic
KW - oxidative stress
KW - red blood cells
KW - sodium meta-arsenite
LA - eng
IS - 1522-7278 (Electronic)
PT - Journal Article
TA - Environ Toxicol
YR - 2018
DATE- 20180507
CI - &copy; 2018 Wiley Periodicals, Inc.
CITO- NLM
CS - United States
FJT - Environmental toxicology
EDAT- 20180506
STAT- Publisher
DOCNO- medline/29732668

158 - TOXLINE
TI - Long-Term Health Effects and Underlying Biological Mechanisms of
Developmental Exposure to Arsenic.
AU - Smeester L
AD - Department of Environmental Sciences and Engineering, Gillings School of
Global Public Health, University of North Carolina, Chapel Hill, NC, USA.
AU - Fry RC
AD - Curriculum in Toxicology, School of Medicine, University of North Carolina,
Chapel Hill, NC, USA. rfry@unc.edu.
SO - Curr Environ Health Rep. 2018, Mar; 5(1):134-144. [Current environmental
health reports]
AB - PURPOSE OF REVIEW: Exposure to inorganic arsenic (iAs) via drinking water
represents a significant global public health threat with chronic exposure
associated with cancer, skin lesions, neurological impairment, and
cardiovascular diseases. Particularly susceptible populations include the
developing fetus and young children. This review summarizes some of the
critical studies of the long-term health effects and underlying biological
mechanisms related to developmental exposure to arsenic. It also
highlights the complex factors, such as the sex of the exposed individual,
that contribute to susceptibility to the later life health effects of iAs.
AB - RECENT FINDINGS: Studies in animal models, as well as human
population-based studies, have established that prenatal and early life
iAs exposures are associated with long-term effects, and many of these
effects display sexually dimorphic responses. As an underlying molecular
basis, recent epidemiologic and toxicologic studies have demonstrated that
changes to the epigenome may play a key mechanistic role underlying many
of the iAs-associated health outcomes. Developmental exposure to iAs
results in early and later life health effects. Mechanisms underlying
these outcomes are likely complex, and include disrupted key biological
pathways with ties to the epigenome. This highlights the importance of
continued research, particularly in animal models, to elucidate the
important underpinnings (e.g., timing of exposure, metabolism, dose) of
these complex health outcomes and to identify the biological mechanisms
underlying sexual dimorphism in iAs-associated diseases. Future research
should investigate preventative strategies for the protection from the
detrimental health endpoints associated with early life exposure to iAs.
Such strategies could include potential interventions focused on dietary
supplementation for example the adoption of a folate-rich diet.
KW - Arsenic exposure
KW - Early life
KW - Epigenetics
KW - In utero
KW - Sexual dimorphism
LA - eng
IS - 2196-5412 (Electronic)
PT - Journal Article
PT - Review
TA - Curr Environ Health Rep
YR - 2018
DATE- 20180402
CITO- NLM
CS - Switzerland
FJT - Current environmental health reports
STAT- In-Data-Review
CM - Cites: Environ Toxicol Pharmacol. 2017 Jun;52:183-187 (medline /28433805)
CM - Cites: Toxicol Sci. 2014 Jun;139(2):328-37 (medline /24675094)
CM - Cites: PLoS Genet. 2007 Nov;3(11):e207 (medline /18039032)
CM - Cites: FASEB J. 2006 Apr;20(6):779-81 (medline /16461332)
CM - Cites: Environ Health Perspect. 2012 May;120(5):623-6 (medline /22336149)
CM - Cites: Epidemiology. 2007 Jan;18(1):44-51 (medline /17149142)
CM - Cites: Cancer Metastasis Rev. 2010 Mar;29(1):61-72 (medline /20094757)
CM - Cites: Epigenetics. 2014 Feb;9(2):212-21 (medline /24169490)
CM - Cites: JAMA Pediatr. 2016 Jun 1;170(6):609-16 (medline /27111102)
CM - Cites: Mol Carcinog. 2007 Aug;46(8):579-84 (medline /17583566)
CM - Cites: Environ Mol Mutagen. 2014 Apr;55(3):196-208 (medline /24327377)
CM - Cites: Environ Health Perspect. 2015 May;123(5):412-21 (medline /25626053)
CM - Cites: Environ Health Perspect. 2013 Sep;121(9):1090-6 (medline /23757599)
CM - Cites: Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 (medline /12583988)
CM - Cites: Toxicol Appl Pharmacol. 2009 Feb 15;235(1):105-13 (medline
/19095001)
CM - Cites: Environ Health Perspect. 2016 Jun;124(6):840-7 (medline /26359651)
CM - Cites: Am J Epidemiol. 2007 Dec 15;166(12):1381-91 (medline /17875584)
CM - Cites: Ann Intern Med. 2013 Nov 19;159(10):649-59 (medline /24061511)
CM - Cites: Hypertension. 1999 Jan;33(1):74-8 (medline /9931084)
CM - Cites: Am J Epidemiol. 2009 Feb 1;169(3):304-12 (medline /19037006)
CM - Cites: Environ Health Perspect. 2016 Aug;124(8):1299-307 (medline
/26955061)
CM - Cites: Environ Health Perspect. 2011 Feb;119(2):258-64 (medline /20940111)
CM - Cites: Neurotoxicol Teratol. 2016 Jan-Feb;53:75-80 (medline /26689609)
CM - Cites: Environ Health Perspect. 2007 Sep;115(9):1371-5 (medline /17805430)
CM - Cites: Toxicol Sci. 2015 Jan;143(1):97-106 (medline /25304211)
CM - Cites: Epigenomics. 2017 Mar;9(3):267-278 (medline /28234023)
CM - Cites: Toxicol Sci. 2011 Jan;119(1):73-83 (medline /20937726)
CM - Cites: Environ Health. 2015 Feb 28;14:19 (medline /25888735)
CM - Cites: Toxicol Sci. 2012 Jan;125(1):20-9 (medline /22011395)
CM - Cites: Environ Health. 2014 Apr 01;13(1):23 (medline /24684736)
CM - Cites: Int J Epidemiol. 2013 Aug;42(4):1077-86 (medline /24062297)
CM - Cites: Toxicol Lett. 2009 Mar 28;185(3):197-202 (medline /19167470)
CM - Cites: Int J Epidemiol. 2010 Oct;39(5):1206-16 (medline /20085967)
CM - Cites: Arch Toxicol. 2014 Aug;88(8):1619-29 (medline /25005685)
CM - Cites: Environ Toxicol Pharmacol. 2015 Mar;39(2):589-96 (medline
/25682005)
CM - Cites: Environ Health Perspect. 2012 Oct;120(10):1418-24 (medline
/23008276)
CM - Cites: Cancer Res. 2008 Oct 15;68(20):8278-85 (medline /18922899)
CM - Cites: Am J Epidemiol. 2003 Dec 15;158(12):1193-201 (medline /14652304)
CM - Cites: Environ Toxicol Pharmacol. 2013 Nov;36(3):1266-75 (medline
/24211595)
CM - Cites: Environ Health Perspect. 2006 Aug;114(8):1293-6 (medline /16882542)
CM - Cites: Toxicol Sci. 2012 Oct;129(2):305-14 (medline /22713597)
CM - Cites: Environ Health Perspect. 2011 May;119(5):719-24 (medline /21147604)
CM - Cites: Toxicol Sci. 2014 Sep;141(1):166-75 (medline /24924402)
CM - Cites: Toxicol Appl Pharmacol. 2007 May 1;220(3):284-91 (medline
/17350061)
CM - Cites: Environ Health Perspect. 2012 Nov;120(11):1527-31 (medline
/22949133)
CM - Cites: Int J Epidemiol. 2013 Feb;42(1):176-85 (medline /23243118)
CM - Cites: Environ Health Perspect. 2000 Jul;108(7):667-73 (medline /10903622)
CM - Cites: Environ Health. 2013 Sep 02;12(1):73 (medline /24004508)
CM - Cites: Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):504-10 (medline
/8624771)
CM - Cites: PLoS One. 2012;7(6):e38713 (medline /22719926)
CM - Cites: Environ Health Perspect. 2015 Feb;123(2):186-92 (medline /25325819)
CM - Cites: Environ Health. 2006 Oct 31;5:31 (medline /17076881)
CM - Cites: Twin Res Hum Genet. 2007 Aug;10 (4):581-6 (medline /17708699)
CM - Cites: Neurotoxicology. 2011 Aug;32(4):450-7 (medline /21453724)
CM -Cites: Environ Int. 2012 Jan;38(1):10-6 (medline /21982028)
CM -Cites: J Natl Cancer Inst. 2016 May 02;108(9):null (medline /27140955)
CM -Cites: PLoS One. 2013;8(1):e55014 (medline /23383038)
CM -Cites: Carcinogenesis. 2004 Jan;25(1):133-41 (medline /14514661)
CM -Cites: Environ Health Perspect. 2008 Apr;116(4):524-31 (medline /18414638)
CM -Cites: Int J Hyg Environ Health. 2014 Jul;217(6):678-86 (medline
/24698386)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):1982-7 (medline
/18708388)
CM - Cites: Environ Res. 2013 Oct;126:24-30 (medline /23769261)
CM - Cites: Annu Rev Nutr. 2009;29:381-99 (medline /19575603)
CM - Cites: J Pediatr (Rio J). 2007 Nov-Dec;83(6):494-504 (medline /18074050)
CM - Cites: Oncotarget. 2014 Mar 15;5(5):1290-303 (medline /24675390)
CM - Cites: Cancer Res. 2006 Feb 15;66(4):1883-90; discussion 1895-6 (medline
/16488983)
CM - Cites: Circulation. 1973 Feb;47(2):270-5 (medline /4684927)
CM - Cites: Environ Res. 2017 Jul;156:426-433 (medline /28410520)
CM - Cites: Environ Health Perspect. 2016 Mar;124(3):336-43 (medline /26295903)
CM - Cites: Hum Exp Toxicol. 2008 May;27(5):381-6 (medline /18715884)
CM - Cites: Toxicol Lett. 2002 Jul 7;133(1):17-31 (medline /12076507)
CM - Cites: Epigenetics. 2012 Oct;7(10):1125-32 (medline /22907587)
CM - Cites: Environ Health. 2015 Mar 30;14:12 (medline /25971349)
CM - Cites: BMJ. 2011 May 05;342:d2431 (medline /21546419)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007
Jan-Mar;25(1):1-22 (medline /17365340)
CM - Cites: J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 (medline /15026472)
CM - Cites: Toxicology. 2007 Jul 1;236(1-2):7-15 (medline /17451858)
CM - Cites: Nat Genet. 2013 Jan;45(1):76-82 (medline /23202124)
CM - Cites: Environ Health Perspect. 2013 Mar;121(3):295-302 (medline
/23458756)
CM - Cites: Int J Epidemiol. 2011 Dec;40(6):1593-604 (medline /22158669)
CM - Cites: Cell Mol Life Sci. 2014 Jan;71(2):271-85 (medline /23892892)
CM - Cites: Epigenetics. 2014 May;9(5):774-82 (medline /24525453)
CM - Cites: Arch Pathol. 1974 Jun;97(6):360-5 (medline /4825098)
CM - Cites: Environ Int. 2017 Apr;101:108-116 (medline /28159392)
CM - Cites: J Appl Toxicol. 2015 Apr;35(4):358-66 (medline /25131850)
CM - Cites: Toxicol Sci. 1998 Aug;44(2):185-90 (medline /9742656)
CM - Cites: Pediatrics. 2006 Oct;118(4):1486-92 (medline /17015539)
CM - Cites: Int Arch Occup Environ Health. 2011 Aug;84(6):591-600 (medline
/20972800)
CM - Cites: Nutrients. 2014 Jun 02;6(6):2165-78 (medline /24892374)
CM - Cites: Biomed Res Int. 2015;2015:175025 (medline /26339590)
CM - Cites: Arch Toxicol. 2012 Jun;86(6):975-82 (medline /22398986)
CM - Cites: Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 (medline
/17306315)
CM - Cites: Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):204-11 (medline
/18226075)
CM - Cites: Front Neurosci. 2016 Mar 31;10:137 (medline /27064386)
DOCNO- medline/29411302

159 - TOXLINE
TI - Adiponectin gene polymorphisms and obesity increase the susceptibility to
arsenic-related renal cell carcinoma.
AU - Hsueh YM
AD - Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University,
Taipei, Taiwan; Department of Public Health, School of Medicine, College of
Medicine, Taipei Medical University, Taipei, Taiwan.
AU - Chen WJ
AD - Department of Biostatistics and Epidemiology, College of Public Health,
University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; School of
Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan.
AU - Lin YC
AD - Department of Family Medicine, Shuang Ho Hospital, Taipei Medical University,
Taipei, Taiwan; Department of Health Examination, Wan Fang Hospital, Taipei Medical
University, Taipei, Taiwan; Division of Family Medicine, School of Medicine, Taipei
Medical University, Taipei, Taiwan.
AU - Huang CY
AD - Department of Urology, National Taiwan University Hospital, College of
Medicine, National Taiwan University, Taipei, Taiwan; Department of Urology,
National Taiwan University Hospital, Hsin Chu Branch, Hsin Chu, Taiwan.
AU - Shiue HS
AD - Department of Chinese Medicine, Chang Gung Memorial Hospital and Chang Gung
University, College of Medicine, Taoyuan, Taiwan.
AU - Yang SM
AD - School of Public Health, College of Public Health, Taipei Medical University,
Taipei, Taiwan.
AU - Ao PL
AD - School of Public Health, College of Public Health, Taipei Medical University,
Taipei, Taiwan.
AU - Pu YS
AD - Department of Health Examination, Wan Fang Hospital, Taipei Medical
University, Taipei, Taiwan.
AU - Su CT
AD - School of Public Health, College of Public Health, Taipei Medical University,
Taipei, Taiwan; Department of Family Medicine, Taipei Medical University Hospital,
Taipei, Taiwan. Electronic address: ctsu@tmu.edu.tw.
SO - Toxicol Appl Pharmacol. 2018, Jul 01; 350:11-20. [Toxicology and applied
pharmacology]
AB - Our recent study found that high urinary total arsenic levels were
associated with renal cell carcinoma (RCC). Recent studies demonstrated
that low circulating adiponectin was related to RCC. The aim of the
present study was to explore the relationship between adiponectin gene
(ADIPOQ) polymorphisms and RCC and investigate whether individuals with an
ADIPOQ risk genotype, obesity, and high urinary total arsenic levels have
a modified odds ratio (OR) of RCC. A total of 389 RCC patients and 389
age- and sex-matched controls were recruited between November 2006 and
December 2012 in Taiwan. Image-guided biopsy or surgical resection of
renal tumors was performed to pathologically verify RCC. Genomic DNA was
used to examine the genotypes of the ADIPOQ rs182052, ADIPOQ rs2241766,
ADIPOQ rs1501299, and ADIPOQ rs1063539 SNPs by PCR-RFLP. HPLC-HG-AAS was
used to measure the concentrations of urinary arsenic species.
Participants with the ADIPOQ rs182052 G/A+A/A genotype had a significantly
higher OR of RCC compared with those with the ADIPOQ rs182052 G/G
genotype. The OR (95% confidence interval [CI]) was 1.70 (1.23-2.36). The
OR of RCC for the combined effect of high urinary total arsenic levels and
obesity, which was dose-dependent, in individuals with the ADIPOQ rs182052
G/A+A/A genotype was 9.33 (3.85-22.62). The present study found
significant combined effects of obesity and the ADIPOQ rs182052 G/A+A/A
genotype on the arsenic-related risk of RCC in a population with low
arsenic exposure. Arsenic exposure, obesity, and the ADIPOQ rs182052
polymorphism could be predictors of a higher OR of RCC.
KW - ADIPOQ
KW - Arsenic
KW - Obesity
KW - Polymorphism
KW - Renal Cell Carcinoma
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180525
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20180430
STAT- In-Data-Review
DOCNO- medline/29723618

160 - TOXLINE
TI - Enhanced adsorption performance of aspartic acid intercalated Mg-Zn-Fe-LDH
materials for arsenite.
AU - Lu H
AD - State Key Laboratory of Pollution Control and Resource Reuse, Tongji
University, Shanghai 200092, China. zzl@tongji.edu.cn and Post Doctoral Research
Station, College of Civil Engineering, Tongji University, Shanghai 200092, China.
AU - Lu T
AD - State Key Laboratory of Pollution Control and Resource Reuse, Tongji
University, Shanghai 200092, China. zzl@tongji.edu.cn.
AU - Zhang H
AD - State Key Laboratory of Pollution Control and Resource Reuse, Tongji
University, Shanghai 200092, China. zzl@tongji.edu.cn.
AU - Qiu Y
AD - Key Laboratory of Yangtze River Water Environment, Ministry of Education,
Tongji University, Shanghai 200092, China.
AU - Yin D
AD - Key Laboratory of Yangtze River Water Environment, Ministry of Education,
Tongji University, Shanghai 200092, China.
AU - Zhu Z
AD - State Key Laboratory of Pollution Control and Resource Reuse, Tongji
University, Shanghai 200092, China. zzl@tongji.edu.cn and Key Laboratory of Yangtze
River Water Environment, Ministry of Education, Tongji University, Shanghai 200092,
China.
SO - Dalton Trans. 2018, Apr 03; 47(14):4994-5004. [Dalton transactions
(Cambridge, England : 2003)]
AB - A series of hydrophobic and hydrophilic amino acid (aspartic acid,
phenylalanine, glutamic acid, and proline) intercalated LDH materials were
synthesized and characterized. The results of batch experiments showed
that Mg7Zn1Fe4-Asp-LDH and Mg7Zn1Fe4-Phe-LDH showed good adsorption
performances for both arsenate and arsenite in aqueous solutions. The
effects of various experimental conditions have been investigated by the
batch test, which included the effects of initial pH, arsenic
concentration, contact time and coexisting ions. For Mg7Zn1Fe4-Asp-LDH
under the optimal experimental conditions, the maximum adsorption capacity
of As(iii) and As(v) reached 94.81 mg g-1 and 57.42 mg g-1, respectively.
It showed a higher adsorption capacity for As(iii) than that for As(v),
which is of great significance to remove the trivalent arsenic species
with higher toxicity. When the dosage of Mg7Zn1Fe4-Asp-LDH was 0.8 g L-1,
the concentration of As(iii) in the aqueous solution could be reduced from
2 mg L-1 to below 10 &mu;g L-1.When Mg-Zn-Fe-Asp-LDH was applied in
practical water samples with a dosage of 0.2 g L-1, the residual
concentrations of arsenic in three actual water samples were all lower
than 10 &mu;g L-1 after adsorption. The column test showed that 1.0 g of
Mg7Zn1Fe4-Asp-LDH could continuously treat 2.6 L of As(iii) aqueous
solution (2 mg L-1) and reduced the concentration of As(iii) to below 10
&mu;g L-1 or handle 0.4 L of arsenic-contaminated (10 mg L-1,
As(iii)&thinsp;:&thinsp;As(v) = 1&thinsp;:&thinsp;1) water, and the
effluent concentration was below 10 &mu;g L-1. Compared with the
previously reported hydrophobic amino acid intercalated LDHs, aspartic
acid (hydrophilic amino acid) intercalated LDH has a good removal
efficiency for arsenic. The synthesized Mg7Zn1Fe4-Asp-LDH is considered to
be a potentially functional material that can be used to treat arsenic
contamination in water.
LA - eng
IS - 1477-9234 (Electronic)
PT - Journal Article
TA - Dalton Trans
YR - 2018
DATE- 20180404
CITO- NLM
CS - England
FJT - Dalton transactions (Cambridge, England : 2003)
STAT- PubMed-not-MEDLINE
DOCNO- medline/29557460

161 - TOXLINE
TI - Iron Mesh-Based Metal Organic Framework Filter for Efficient Arsenic
Removal.
AU - Wang D
AU - Gilliland SE 3rd
AU - Yi X
AU - Logan K
AU - Heitger DR
AU - Lucas HR
AU - Wang WN
SO - Environ Sci Technol. 2018, Apr 03; 52(7):4275-4284. [Environmental science
& technology]
AB - Efficient oxidation from arsenite [As(III)] to arsenate [As(V)], which is
less toxic and more readily to be adsorbed by adsorbents, is important for
the remediation of arsenic pollution. In this paper, we report a metal
organic framework (MIL-100(Fe)) filter to efficiently remove arsenic from
synthetic groundwater. With commercially available iron mesh as a
substrate, MIL-100(Fe) is implanted through an in situ growth method.
MIL-100(Fe) is able to capture As(III) due to its microporous structure,
superior surface area, and ample active sites for As adsorption. This
approach increases the localized As concentration around the filter, where
Fenton-like reactions are initiated by the Fe2+/Fe3+ sites within the
MIL-100(Fe) framework to oxidize As(III) to As(V). The mechanism was
confirmed by colorimetric detection of H2O2, fluorescence, and electron
paramagnetic resonance detection of &middot;OH. With the aid of oxygen
bubbling and Joule heating, the removal efficiency of As(III) can be
further boosted. The MIL-100(Fe)-based filter also exhibits satisfactory
structural stability and recyclability. Notably, the adsorption capacity
of the filter can be regenerated satisfactorily. Our results demonstrate
the potential of this filter for the efficient remediation of As
contamination in groundwater.
LA - eng
IS - 1520-5851 (Electronic)
PT - Journal Article
TA - Environ Sci Technol
YR - 2018
DATE- 20180403
CITO- NLM
CS - United States
FJT - Environmental science &amp; technology
EDAT- 20180315
STAT- In-Data-Review
DOCNO- medline/29513011

162 - TOXLINE
TI - Efficient oxidation and sorption of arsenite using a novel
titanium(IV)-manganese(IV) binary oxide sorbent.
AU - Zhang W
AD - State Key Laboratory of Urban Water Resource and Environment, School of
Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, China.
AU - Liu C
AD - State Key Laboratory of Urban Water Resource and Environment, School of
Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, China.
AU - Zheng T
AD - State Key Laboratory of Urban Water Resource and Environment, School of
Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, China.
AU - Ma J
AD - State Key Laboratory of Urban Water Resource and Environment, School of
Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, China.
Electronic address: majun@hit.edu.cn.
AU - Zhang G
AD - Collaborative Innovation Center of Water Quality Safety and Protection in
Pearl River Delta, Guangzhou University, Guangzhou 510006, China. Electronic
address: gszhang@gzhu.edu.cn.
AU - Ren G
AD - China University of Mining and Technology, Xuzhou, Jiangsu 221116, China.
AU - Wang L
AD - State Key Laboratory of Urban Water Resource and Environment, School of
Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, China.
AU - Liu Y
AD - State Key Laboratory of Urban Water Resource and Environment, School of
Environment, Harbin Institute of Technology, Harbin, Heilongjiang 150090, China.
SO - J Hazard Mater. 2018, Jul 05; 353:410-420. [Journal of hazardous
materials]
AB - Owing to the high toxicity and mobility, the removal of arsenite (As(III))
is significantly more difficult than arsenate (As(V)), thus representing a
major challenge in arsenite-contaminated water treatment. For efficient
elimination of As(III), we successfully fabricated a novel Ti-Mn binary
oxide via a simultaneous oxidation and coprecipitation process. The
amorphous oxide was aggregated from nanosized particles with a high
specific surface area of 349.5&#8239;m2/g. It could effectively oxidize
As(III) to As(V) and had a high As(III) sorption capacity of
107.0&#8239;mg/g. As(III) sorption occurred rapidly and equilibrium was
achieved within 24&#8239;h. The kinetic data was well fitted by the
pseudo-second-order equation, indicating a chemical sorption process. The
material was almost independent upon the presence of competitive ions. The
As(III) removal by the sorbent is a combined process coupled oxidation
with sorption, where the MnO2 content is mainly responsible for oxidizing
As(III) to As(V) and the formed As(V) is then adsorbed onto the surface of
amorphous TiO2 content, through replacing the surface hydroxyl group or
the adsorbed As(III) and forming inner-sphere surface complexes.
Furthermore, the arsenic-containing oxide could be effectively regenerated
and reused. The bi-functional sorbent could be used as a potentially
attractive sorbent for As(III) removal in drinking water treatment and
environmental remediation.
KW - Arsenite
KW - Oxidation
KW - Sorption
KW - Ti-Mn binary oxide
KW - Water treatment
LA - eng
IS - 1873-3336 (Electronic)
PT - Journal Article
TA - J Hazard Mater
YR - 2018
DATE- 20180615
CI - Copyright &copy; 2018. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
FJT - Journal of hazardous materials
EDAT- 20180419
STAT- In-Data-Review
DOCNO- medline/29702456

163 - TOXLINE
TI - CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the
Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant
Transformation of Human Keratinocytes.
AU - Xue J
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Chen C
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Luo F
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Pan X
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, Guizhou 550025, People's Republic of China.
AU - Xu H
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Yang P
AD - The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou
Medical University, Guangzhou, Guangdong 510182, People's Republic of China.
AU - Sun Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Liu X
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Lu L
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Yang Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Xiao T
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Dai X
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
AU - Luo P
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, Guizhou 550025, People's Republic of China.
AU - Lu J
AD - The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou
Medical University, Guangzhou, Guangdong 510182, People's Republic of China.
AU - Zhang A
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, Guizhou 550025, People's Republic of China.
AU - Liu Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, People's
Republic of China.
SO - Toxicol Sci. 2018, Apr 01; 162(2):450-461. [Toxicological sciences : an
official journal of the Society of Toxicology]
AB - Circular RNAs (circRNAs), a class of noncoding RNAs generated from
pre-mRNAs, participate in the regulation of tumorigenesis. The mechanism
for regulation, however, is unclear. Here, to determine whether circRNAs
are involved in arsenite-induced epithelial-mesenchymal transition (EMT)
and malignant transformation in human keratinocyte (HaCaT) cells, the
up-regulation of circLRP6 was confirmed in arsenite-transformed HaCaT
(T-HaCaT) cells. In HaCaT cells, circLRP6 acted as an microRNA (miR)-455
sponge. For these cells, chronic exposure to arsenite caused an increase
of circLRP6 and the transcription factor ZEB1, which induced the EMT.
miR-455 suppressed the expression of ZEB1. Further, in T-HaCaT cells,
knockdown of circLRP6 with siRNA inhibited ZEB1 expression, but
cotransfection with circLRP6 siRNA and an miR-455 inhibitor reversed this
inhibition. These results suggest that, in HaCaT cells, arsenite increases
circLRP6 levels, which act as a sponge for miR-455 and up-regulate the
miR-455 target, ZEB1, which subsequently induces the EMT, thus promoting
malignant transformation. Thus, for HaCaT cells chronically exposed to
arsenite, circLRP6 via miR-455 regulation of ZEB1 is involved in the EMT
during malignant transformation. The results establish a previously
unknown mechanism for arsenite-induced carcinogenesis.
LA - eng
IS - 1096-0929 (Electronic)
PT - Journal Article
TA - Toxicol Sci
YR - 2018
DATE- 20180328
CITO- NLM
CS - United States
FJT - Toxicological sciences : an official journal of the Society of Toxicology
STAT- In-Data-Review
DOCNO- medline/29216394

164 - TOXLINE
TI - Inorganic arsenic causes fatty liver and interacts with ethanol to cause
alcoholic liver disease in zebrafish.
AU - Bambino K
AD - Department of Environmental Medicine and Public Health, Icahn School of
Medicine at Mount Sinai, New York, New York 10029, USA.
AU - Zhang C
AD - Program in Biology, New York University Abu Dhabi, Saadiyat Island Campus, PO
Box 129188 Abu Dhabi, United Arab Emirates.
AU - Austin C
AD - Department of Environmental Medicine and Public Health, Icahn School of
Medicine at Mount Sinai, New York, New York 10029, USA.
AU - Amarasiriwardena C
AD - Department of Environmental Medicine and Public Health, Icahn School of
Medicine at Mount Sinai, New York, New York 10029, USA.
AU - Arora M
AD - Department of Environmental Medicine and Public Health, Icahn School of
Medicine at Mount Sinai, New York, New York 10029, USA.
AU - Chu J
AD - Department of Pediatrics, Division of Pediatric Hepatology, Icahn School of
Medicine at Mount Sinai, New York, New York 10029, USA.
AU - Sadler KC
AD - Program in Biology, New York University Abu Dhabi, Saadiyat Island Campus, PO
Box 129188 Abu Dhabi, United Arab Emirates Kirsten.Edepli@nyu.edu.
SO - Dis Model Mech. 2018, 02 26. [Disease models & mechanisms]
AB - The rapid increase in fatty liver disease (FLD) incidence is attributed
largely to genetic and lifestyle factors; however, environmental toxicants
are a frequently overlooked factor that can modify the effects of more
common causes of FLD. Chronic exposure to inorganic arsenic (iAs) is
associated with liver disease in humans and animal models, but neither the
mechanism of action nor the combinatorial interaction with other
disease-causing factors has been fully investigated. Here, we examined the
contribution of iAs to FLD using zebrafish and tested the interaction with
ethanol to cause alcoholic liver disease (ALD). We report that zebrafish
exposed to iAs throughout development developed specific phenotypes
beginning at 4&#8197;days post-fertilization (dpf), including the
development of FLD in over 50% of larvae by 5&#8197;dpf. Comparative
transcriptomic analysis of livers from larvae exposed to either iAs or
ethanol revealed the oxidative stress response and the unfolded protein
response (UPR) caused by endoplasmic reticulum (ER) stress as common
pathways in both these models of FLD, suggesting that they target similar
cellular processes. This was confirmed by our finding that arsenic is
synthetically lethal with both ethanol and a well-characterized
ER-stress-inducing agent (tunicamycin), suggesting that these exposures
work together through UPR activation to cause iAs toxicity. Most
significantly, combined exposure to sub-toxic concentrations of iAs and
ethanol potentiated the expression of UPR-associated genes, cooperated to
induce FLD, reduced the expression of as3mt, which encodes an
arsenic-metabolizing enzyme, and significantly increased the concentration
of iAs in the liver. This demonstrates that iAs exposure is sufficient to
cause FLD and that low doses of iAs can potentiate the effects of ethanol
to cause liver disease.This article has an associated First Person
interview with the first author of the paper.
COI - Competing interestsThe authors declare no competing or financial
interests.
KW - *Arsenic
KW - *Environmental exposure
KW - *Ethanol
KW - *Fatty liver disease
LA - eng
IS - 1754-8411 (Electronic)
PT - Journal Article
PT - Research Support, N.I.H., Extramural
TA - Dis Model Mech
YR - 2018
DATE- 20180521
CI - &copy; 2018. Published by The Company of Biologists Ltd.
CITO- NLM
CS - England
FJT - Disease models &amp; mechanisms
EDAT- 20180226
STAT- In-Process
CM - Cites: Indian J Gastroenterol. 2000 Jul-Sep;19(3):112-5 (medline
/10918716)
CM - Cites: BMC Public Health. 2012 Aug 10;12:639 (medline /22883023)
CM - Cites: Sci Prog. 1999;82 ( Pt 1):69-88 (medline /10445007)
CM - Cites: Bioinformatics. 2015 Jan 15;31(2):166-9 (medline /25260700)
CM - Cites: Database (Oxford). 2016 Jun 23;2016: (medline /27337980)
CM - Cites: Toxicol Pathol. 2013 Feb;41(2):343-60 (medline /23262638)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):319-26 (medline
/15276411)
CM - Cites: Toxicol Appl Pharmacol. 2009 Mar 15;235(3):338-50 (medline
/19168087)
CM - Cites: Mass Spectrom Rev. 2017 Jan;36(1):47-57 (medline /26398248)
CM - Cites: Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110403
(medline /23530257)
CM - Cites: Environ Health Perspect. 2016 Feb;124(2):201-9 (medline /26151952)
CM - Cites: Arch Toxicol. 2014 Feb;88(2):213-26 (medline /23892647)
CM - Cites: Curr Opin Lipidol. 2014 Apr;25(2):125-32 (medline /24565920)
CM - Cites: Ann Epidemiol. 2007 Nov;17(11):863-9 (medline /17728149)
CM - Cites: Toxicol Lett. 2002 Jul 7;133(1):1-16 (medline /12076506)
CM - Cites: Nat Rev Gastroenterol Hepatol. 2015 Apr;12(4):231-42 (medline
/25782093)
CM - Cites: Environ Sci Technol. 2009 Apr 15;43(8):2714-9 (medline /19475939)
CM - Cites: Pharmacol Ther. 2016 May;161:11-21 (medline /27016469)
CM - Cites: Environ Health Perspect. 2012 Jul;120(7):1061-6 (medline /22466225)
CM - Cites: Ann Intern Med. 2013 Nov 19;159(10):649-59 (medline /24061511)
CM - Cites: J Expo Sci Environ Epidemiol. 2006 Mar;16(2):191-205 (medline
/16160703)
CM - Cites: PLoS One. 2016 Mar 11;11(3):e0151225 (medline /26967897)
CM - Cites: Bioinformatics. 2009 May 1;25(9):1105-11 (medline /19289445)
CM - Cites: J Appl Toxicol. 2011 Mar;31(2):95-107 (medline /21321970)
CM - Cites: Hepatology. 2011 Jul;54(1):229-39 (medline /21503947)
CM - Cites: Hepatology. 2010 May;51(5):1593-602 (medline /20222092)
CM - Cites: Mol Cell Biochem. 2004 Jan;255(1-2):57-66 (medline /14971646)
CM - Cites: Toxicol Lett. 2012 Jul 20;212(2):161-8 (medline /22613031)
CM - Cites: PLoS Genet. 2014 May 29;10(5):e1004335 (medline /24874946)
CM - Cites: Environ Health. 2011 Jul 08;10:64 (medline /21740555)
CM - Cites: PLoS One. 2013 Jul 29;8(7):e68737 (medline /23922661)
CM - Cites: Analyst. 2012 Apr 7;137(7):1527-37 (medline /22314636)
CM - Cites: Free Radic Biol Med. 2015 Mar;80:171-82 (medline /25091901)
CM - Cites: Mol Biol Cell. 2010 Sep 1;21(17):2975-86 (medline /20631254)
CM - Cites: Sci Rep. 2017 Mar 17;7:44424 (medline /28303940)
CM - Cites: Bioinformatics. 2014 Aug 1;30(15):2114-20 (medline /24695404)
CM - Cites: Arch Toxicol. 2013 Jun;87(6):969-79 (medline /22811022)
CM - Cites: Hepatology. 2009 Feb;49(2):443-52 (medline /19127516)
CM - Cites: Int J Environ Res Public Health. 2015 Oct 12;12(10):12628-42
(medline /26473898)
CM - Cites: Toxicol Sci. 2016 Nov;154(1):195 (medline /27794142)
CM - Cites: Biol Trace Elem Res. 2017 Mar;176(1):154-175 (medline /27498811)
CM - Cites: Zebrafish. 2013 Jun;10(2):199-210 (medline /23697887)
CM - Cites: Oncol Rep. 2012 Nov;28(5):1851-8 (medline /22922937)
CM - Cites: BMC Mol Biol. 2009 Nov 25;10:104 (medline /19939263)
CM - Cites: Toxicol Appl Pharmacol. 2011 Dec 15;257(3):356-64 (medline
/21983427)
CM - Cites: Genome Biol. 2004;5(10):R80 (medline /15461798)
CM - Cites: J Epidemiol Community Health. 2014 Feb;68(2):176-84 (medline
/24133074)
CM - Cites: Environ Mol Mutagen. 2016 Mar;57(2):137-50 (medline /26581878)
CM - Cites: Front Oncol. 2017 Apr 03;7:55 (medline /28421160)
CM - Cites: Mutat Res. 2016 Oct;809:50-56 (medline /27692299)
CM - Cites: Arch Toxicol. 1988;62(6):473-5 (medline /3250379)
CM - Cites: Dis Model Mech. 2014 Jul;7(7):823-35 (medline /24973751)
CM - Cites: Mol Biosyst. 2014 Apr;10 (4):851-861 (medline /24488121)
CM - Cites: Arch Environ Occup Health. 2016 Nov;71(6):338-346 (medline
/26666397)
CM - Cites: J Cell Sci. 2012 Nov 1;125(Pt 21):5073-83 (medline /22946053)
CM - Cites: Alcohol Clin Exp Res. 2012 Jan;36(1):14-23 (medline /21790674)
CM - Cites: Toxicol Pathol. 2015 Jun;43(4):482-97 (medline /25326588)
CM - Cites: Zebrafish. 2016 Oct;13(5):405-12 (medline /27140519)
CM - Cites: Cancer Cell. 2014 Feb 10;25(2):196-209 (medline /24486181)
CM - Cites: Dis Model Mech. 2013 Sep;6(5):1271-8 (medline /23813869)
CM - Cites: Indian J Gastroenterol. 1999 Oct-Nov;18(4):152-5 (medline
/10531716)
CM - Cites: Toxicol Appl Pharmacol. 2012 Jul 15;262(2):185-93 (medline
/22575231)
CM - Cites: Environ Health Perspect. 2013 Jul;121(7):832-8 (medline /23665672)
CM - Cites: Aquat Toxicol. 2014 Jul;152:152-63 (medline /24768856)
CM - Cites: QJM. 2010 Feb;103(2):71-83 (medline /19914930)
CM - Cites: Curr Top Dev Biol. 2017;124:331-367 (medline /28335863)
CM - Cites: Nature. 2016 Jan 21;529(7586):326-35 (medline /26791723)
CM - Cites: Toxicol Appl Pharmacol. 2007 Apr 15;220(2):146-55 (medline
/17303202)
CM - Cites: Physiol Genomics. 2006 Nov 27;27(3):351-61 (medline /16882884)
CM - Cites: Antioxid Redox Signal. 2007 Dec;9(12):2277-93 (medline /17979528)
CM - Cites: Hepatology. 2011 Aug;54(2):495-508 (medline /21538441)
CM - Cites: Science. 2004 Oct 15;306(5695):457-61 (medline /15486293)
CM - Cites: Free Radic Biol Med. 2008 Mar 1;44(5):723-38 (medline /18078827)
CM - Cites: Aquat Toxicol. 2014 Aug;153:66-72 (medline /24176670)
CM - Cites: Toxicol Appl Pharmacol. 2007 Dec 1;225(2):154-61 (medline
/17905400)
CM - Cites: Environ Health. 2016 Nov 8;15(1):106 (medline /27825389)
CM - Cites: Aquat Toxicol. 2009 Feb 19;91(3):229-37 (medline /19110324)
CM - Cites: Dis Model Mech. 2013 Sep;6(5):1213-26 (medline /23798569)
CM - Cites: Biochemistry. 2009 Jan 20;48(2):424-32 (medline /19102631)
CM - Cites: J Biochem Mol Toxicol. 2015 Jan;29(1):1-9 (medline /25155036)
CM - Cites: Biochemistry. 2015 Jan 20;54(2):612-21 (medline /25506675)
CM - Cites: Gastroenterology. 1998 Apr;114(4):842-5 (medline /9547102)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007
Jan-Mar;25(1):1-22 (medline /17365340)
CM - Cites: Sci Rep. 2015 Nov 05;5:16093 (medline /26537450)
CM - Cites: J Toxicol Clin Toxicol. 2000;38(4):395-405 (medline /10930056)
CM - Cites: Cell Rep. 2013 Apr 25;3(4):1279-92 (medline /23583182)
CM - Cites: Lancet. 2010 Jul 24;376(9737):252-8 (medline /20646756)
CM - Cites: Semin Liver Dis. 2015 Aug;35(3):270-90 (medline /26378644)
CM - Cites: Environ Toxicol Pharmacol. 2016 Dec;48:214-224 (medline /27829199)
CM - Cites: Aquat Toxicol. 2016 Jul;176:45-52 (medline /27108203)
CM - Cites: Hepatology. 2011 Aug;54(2):452-62 (medline /21488074)
CM - Cites: Environ Health Perspect. 2013 Mar;121(3):295-302 (medline
/23458756)
CM - Cites: Histopathology. 2012 Aug;61(2):141-52 (medline /22372457)
CM -Cites: Cell Death Dis. 2013 Dec 19;4:e968 (medline /24357799)
CM -Cites: Free Radic Res. 2015;49(12):1405-18 (medline /26223319)
CM -Cites: Development. 2015 Feb 1;142(3):510-21 (medline /25564650)
CM -Cites: Environ Health Perspect. 2011 Oct;119(10):1356-63 (medline
/21684831)
CM - Cites: Environ Health Perspect. 2002 Oct;110 Suppl 5:883-6 (medline
/12426152)
CM - Cites: Diabetes Care. 2015 Apr;38(4):620-7 (medline /25583752)
CM - Cites: Environ Res. 2014 Nov;135:120-5 (medline /25262084)
CM - Cites: Antioxid Redox Signal. 2012 May 15;16(10):1077-87 (medline
/21854214)
CM - Cites: PLoS One. 2013;8(1):e53732 (medline /23341986)
CM - Cites: Comp Biochem Physiol C Toxicol Pharmacol. 2015 Jun-Jul;172-173:7-12
(medline /25882832)
CM - Cites: Environ Health Perspect. 1996 Jun;104(6):620-8 (medline /8793350)
CM - Cites: Arch Toxicol. 2013 Feb;87(2):383-96 (medline /22914984)
CM - Cites: Mol Cell Biochem. 2004 Jan;255(1-2):67-78 (medline /14971647)
CM - Cites: Development. 2017 Aug 15;144(16):2925-2939 (medline /28698226)
CM - Cites: Gastroenterology. 2015 Nov;149(6):1361-77 (medline /26319012)
CM - Cites: J Clin Invest. 2004 Jul;114(2):147-52 (medline /15254578)
CM - Cites: Toxicol Appl Pharmacol. 2005 Aug 7;206(2):169-75 (medline
/15967205)
CM - Cites: Dig Dis. 2010;28(6):802-11 (medline /21525766)
CM - Cites: Toxicol Lett. 2006 Jun 1;163(3):191-7 (medline /16376500)
CM - Cites: Environ Health Perspect. 2011 Feb;119(2):182-8 (medline /21247820)
CM - Cites: Genome Biol. 2014;15(12):550 (medline /25516281)
DOCNO- medline/29361514

165 - TOXLINE
TI - Gestational exposure to inorganic arsenic (iAs3+) alters glutamate
disposition in the mouse hippocampus and ionotropic glutamate receptor
expression leading to memory impairment.
AU - Nelson-Mora J
AD - Dep. de Medicina Gen�mica y Toxicolog�a Ambiental, Instituto de
Investigaciones Biom�dicas, Universidad Nacional Aut�noma de M�xico, A.P. 70-228,
Ciudad Universitaria, 04510, Mexico, Mexico.
AU - Escobar ML
AD - Divisi�n de Investigaci�n y Estudios de Posgrado, Facultad de Psicolog�a,
Universidad Nacional Aut�noma de M�xico, 04510, Mexico, Mexico.
AU - Rodr�guez-Dur�n L
AD - Divisi�n de Investigaci�n y Estudios de Posgrado, Facultad de Psicolog�a,
Universidad Nacional Aut�noma de M�xico, 04510, Mexico, Mexico.
AU - Massieu L
AD - Divisi�n de Neurociencias, Departamento de Neuropatolog�a Molecular,
Instituto de Fisiolog�a Celular, Universidad Nacional Aut�noma de M�xico, 04510,
Mexico, Mexico.
AU - Montiel T
AD - Divisi�n de Neurociencias, Departamento de Neuropatolog�a Molecular,
Instituto de Fisiolog�a Celular, Universidad Nacional Aut�noma de M�xico, 04510,
Mexico, Mexico.
AU - Rodr�guez VM
AD - Departamento de Neurobiolog�a Conductual y Cognitiva, Instituto de
Neurobiolog�a, Campus Universidad Nacional Aut�noma de M�xico, Juriquilla, 76230,
Quer�taro, Mexico.
AU - Hern�ndez-Mercado K
AD - Dep. de Medicina Gen�mica y Toxicolog�a Ambiental, Instituto de
Investigaciones Biom�dicas, Universidad Nacional Aut�noma de M�xico, A.P. 70-228,
Ciudad Universitaria, 04510, Mexico, Mexico.
AU - Gonsebatt ME
AD - Dep. de Medicina Gen�mica y Toxicolog�a Ambiental, Instituto de
Investigaciones Biom�dicas, Universidad Nacional Aut�noma de M�xico, A.P. 70-228,
Ciudad Universitaria, 04510, Mexico, Mexico. margen@unam.mx.
SO - Arch Toxicol. 2018, Mar; 92(3):1037-1048. [Archives of toxicology]
AB - Early life exposure to environmental pollutants and toxic chemicals has
been linked to learning and behavioral alterations in children. iAs
exposure is associated with different types neurological disorders such as
memory and learning impairment. iAs is methylated in the brain by the
arsenic III-methyltransferase in a process that requires glutathione
(GSH). The xCT-antiporter cell membrane transporter participates in the
influx of cystine for GSH synthesis in exchange for glutamate in a 1:1
ratio. In CD-1 mice gestationally exposed to 20 ppm of sodium
arsenite in drinking water, we have previously observed up-regulation of
xCT in the male mouse hippocampus which caused glutamatergic synapse
alterations affecting learning and memory processes. Here, we used the
same gestational iAs exposure model to investigate whether the
up-regulation of xCT and down-regulation of GLT-1 transporters were
associated with higher levels of extracellular glutamate and changes in
the expression of the
&alpha;-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
glutamate receptor, responsible for excitatory fast synaptic transmission.
The induction of LTP in the perforant-dentate gyrus pathway (PP-DG) of the
hippocampus was also studied, as well as learning and memory formation
using the water maze test. Changes in GSH levels were also tested in the
hippocampus of animals exposed to iAs. Results showed increased GSH
synthesis (p&thinsp; < &thinsp;0.05), associated with significantly
higher extracellular glutamate levels in iAs exposed mice. Exposure was
also significantly associated with AMPA subunits down-regulation,
deficient LTP induction, and lower excitability of the PP-DG pathway. In
addition, animals showed deficient learning and memory in the Morris Water
Maze test.
KW - AMPA receptors
KW - Arsenic neurotoxicity
KW - Extracellular glutamate
KW - LTP
KW - Morris water maze
LA - eng
IS - 1432-0738 (Electronic)
PT - Journal Article
TA - Arch Toxicol
YR - 2018
DATE- 20180325
CITO- NLM
CS - Germany
FJT - Archives of toxicology
EDAT- 20171204
STAT- In-Data-Review
DOCNO- medline/29204679

166 - TOXLINE
TI - May humic acids or mineral fertilisation mitigate arsenic mobility and
availability to carrot plants (Daucus carota L.) in a volcanic soil
polluted by As from irrigation water?
AU - Caporale AG
AD - Department of Agricultural Sciences, University of Naples Federico II,
Portici, Naples, Italy. Electronic address: ag.caporale@unina.it.
AU - Adamo P
AD - Department of Agricultural Sciences, University of Naples Federico II,
Portici, Naples, Italy.
AU - Azam SMGG
AD - Department of Agricultural Sciences, University of Naples Federico II,
Portici, Naples, Italy.
AU - Rao MA
AD - Department of Agricultural Sciences, University of Naples Federico II,
Portici, Naples, Italy.
AU - Pigna M
AD - Department of Agricultural Sciences, University of Naples Federico II,
Portici, Naples, Italy.
SO - Chemosphere. 2018, Feb; 193:464-471. [Chemosphere]
AB - Carrot (Daucus carota L.) is a widely consumed root vegetable, whose
growth and safety might be threatened by growing-medium arsenic (As)
contamination. By this work, we evaluated the effects of humic acids from
Leonardite and NPK mineral fertilisation on As mobility and availability
to carrot plants grown for 60 days in a volcanic soil irrigated with
As-contaminated water - representing the most common scenario occurring in
As-affected Italian areas. As expected, the irrigation with
As-contaminated water caused a serious toxic effect on plant growth and
photosynthetic rate; the highest rate of As also inhibited soil enzymatic
activity. In contrast, the organic and mineral fertilisation alleviated,
at least partially, the toxicity of As, essentially by stimulating plant
growth and promoting nutrient uptake. The mobility of As in the volcanic
soil and thus its phytoavailability were differently affected by the
organic and mineral fertilisers; the application of humic acids mitigated
the availability of the contaminant, likely by its partial immobilisation
on humic acid sorption sites - thus raising up the intrinsic anionic
sorption capacity of the volcanic soil; the mineral fertilisation enhanced
the mobility of As in soil, probably due to competition of P for the
anionic sorption sites of the soil variable-charge minerals, very affine
to available P. These findings hence suggest that a proper soil management
of As-polluted volcanic soils and amendment by stable organic matter might
mitigate the environmental risk of these soils, thus minimising the
availability of As to biota.
KW - Arsenic pollution
KW - Arsenic speciation
KW - Carrot
KW - Humic acids
KW - Phosphorus
KW - Volcanic soil
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180323
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171109
STAT- MEDLINE
DOCNO- medline/29156331

167 - TOXLINE
TI - Arsenic removal from As-hyperaccumulator Pteris vittata biomass: Coupling
extraction with precipitation.
AU - da Silva EB
AD - Research Institute of Rural Sewage Treatment, South West Forestry University,
Yunnan 650224, China; Soil and Water Sciences Department, University of Florida,
Gainesville, FL 32611, United States.
AU - de Oliveira LM
AD - Soil and Water Sciences Department, University of Florida, Gainesville, FL
32611, United States.
AU - Wilkie AC
AD - Soil and Water Sciences Department, University of Florida, Gainesville, FL
32611, United States.
AU - Liu Y
AD - Research Institute of Rural Sewage Treatment, South West Forestry University,
Yunnan 650224, China. Electronic address: yungenliu@swfu.edu.cn.
AU - Ma LQ
AD - Research Institute of Rural Sewage Treatment, South West Forestry University,
Yunnan 650224, China; Soil and Water Sciences Department, University of Florida,
Gainesville, FL 32611, United States. Electronic address: lqma@ufl.edu.
SO - Chemosphere. 2018, Feb; 193:288-294. [Chemosphere]
AB - Proper disposal of As-hyperaccumulator Pteris vittata biomass (Chinese
brake fern) enhances its application in phytoremediation. The goal of this
study was to optimize As removal from P. vittata (PV) biomass by
testing different particle sizes, extractants, extraction times and
solid-to-liquid ratios. PV biomass was extracted using different
extractants followed by different Mg-salts to recover soluble As via
precipitation. Water-soluble As in PV biomass varied from 6.8% to 61% of
total As depending on extraction time, with 99% of As being arsenate
(AsV). Extraction with 2.1% HCl, 2.1% H3PO4, 1 M NaOH and 50% ethanol
recovered 81, 78, 47 and 14% of As from PV biomass. A follow-up extraction
using HCl recovered 27-32% with ethanol recovering only 5%. Though ethanol
showed the lowest extractable As, residual As in the biomass was also the
lowest. Among the extractants, 35% ethanol was the best to remove As from
PV biomass. Approximately 90% As was removed from PV biomass using
particle size < 1 mm at solid:liquid ratio 1:50 and pH 6 for
2 h. Adding MgCl2 at As:Mg ratio of 1:400 with pH 9.5 was effective
to precipitate soluble As, resulting in 98% removal. Effective removal of
As from PV biomass prior to disposal helps make phytoremediation more
feasible.
KW - Arsenic recovery
KW - Ethanol
KW - Extraction
KW - Magnesium arsenate
KW - Precipitation
KW - Speciation
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180322
CI - Published by Elsevier Ltd.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171027
STAT- MEDLINE
DOCNO- medline/29145089

168 - TOXLINE
TI - Geo-Spatial Characterization of Soil Mercury and Arsenic at a
High-Altitude Bolivian Gold Mine.
AU - Johnson GD
AD - Department of Environmental, Occupational and Geospatial Health Sciences,
City University of New York School of Public Health, 55 West 125th St, New York,
NY, 10027, USA. glen.johnson@sph.cuny.edu.
AU - Pavilonis B
AD - Department of Environmental, Occupational and Geospatial Health Sciences,
City University of New York School of Public Health, 55 West 125th St, New York,
NY, 10027, USA.
AU - Caravanos J
AD - Department of Environmental Public Health Sciences, College of Global Public
Health, New York University, 665 Broadway, New York, NY, 10003, USA.
AU - Grassman J
AD - Department of Environmental, Occupational and Geospatial Health Sciences,
City University of New York School of Public Health, 55 West 125th St, New York,
NY, 10027, USA.
SO - Bull Environ Contam Toxicol. 2018, Feb; 100(2):259-264. [Bulletin of
environmental contamination and toxicology]
AB - Soil mercury concentrations at a typical small-scale mine site in the
Bolivian Andes were elevated (28-737 mg/kg or ppm) in localized areas
where mercury amalgams were either formed or vaporized to release gold,
but was not detectable beyond approximately 10 m from its sources.
Arsenic was measurable, exceeding known background levels throughout the
mine site (77-137,022 ppm), and was also measurable through the local
village of Ingenio (36-1803 ppm). Although arsenic levels were high
at all surveyed locations, its spatial pattern followed mercury, being
highest where mercury was high.
KW - Arsenic
KW - Artisanal and small-scale gold mining
KW - Mercury
KW - Soil metal contamination
RN - 7440-57-5
RN - FXS1BY2PGL
RN - N712M78A8G
LA - eng
IS - 1432-0800 (Electronic)
PT - Journal Article
TA - Bull Environ Contam Toxicol
YR - 2018
DATE- 20180515
CITO- NLM
CS - United States
CSET- IM
FJT - Bulletin of environmental contamination and toxicology
EDAT- 20171116
STAT- MEDLINE
DOCNO- medline/29147740

169 - TOXLINE
TI - Concentration of Thyrotropic Hormone in Persons Occupationally Exposed to
Lead, Cadmium and Arsenic.
AU - Jurdziak M
AD - Department of Internal Medicine, Occupational Diseases and Hypertension,
Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
AU - Ga&#263; P
AD - Department of Hygiene, Wroclaw Medical University, Mikulicza-Radeckiego 7,
50-368, Wroclaw, Poland. pawelgac@interia.pl.
AU - Por&#281;ba M
AD - Department of Pathophysiology, Wroclaw Medical University, Marcinkowskiego 1,
50-368, Wroclaw, Poland.
AU - Szyma&#324;ska-Chabowska A
AD - Department of Internal Medicine, Occupational Diseases and Hypertension,
Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
AU - Mazur G
AD - Department of Internal Medicine, Occupational Diseases and Hypertension,
Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
AU - Por&#281;ba R
AD - Department of Internal Medicine, Occupational Diseases and Hypertension,
Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
SO - Biol Trace Elem Res. 2018, Apr; 182(2):196-203. [Biological trace element
research]
AB - Thyroid hormones are essential for body homeostasis. The scientific
literature contains restricted proofs for effects of environmental
chemical factors on thyroid function. The present study aimed at
evaluating the relationship between toxicological parameters and
concentration of thyrotropic hormone in persons occupationally exposed to
lead, cadmium and arsenic. The studies were conducted on 102 consecutive
workers occupationally exposed to lead, cadmium and arsenic (mean age
45.08 &plusmn; 9.87 years). The estimated parameters
characterizing occupational exposure to metals included blood cadmium
concentration (Cd-B), blood lead concentration (Pb-B), blood zinc
protoporphyrin concentration (ZnPP) and urine arsenic concentration
(As-U). Thyroid function was evaluated using the parameter employed in
screening studies, the blood thyrotropic hormone concentration (TSH). No
differences were disclosed in mean values of toxicological parameters
between the subgroup of persons occupationally exposed to lead, cadmium
and arsenic with TSH in and out of the accepted normal values. Logistic
regression demonstrated that higher blood total bilirubin concentrations
(ORu = 4.101; p = 0.025) and higher Cd-B
(ORu = 1.532; p = 0.027) represented independent risk
factors of abnormal values of TSH in this group. In conclusion, in the
group of workers exposed to lead, cadmium and arsenic, higher blood
cadmium concentration seems to augment the risk of abnormal hormonal
thyroid function.
KW - Arsenic
KW - Cadmium
KW - Lead
KW - Occupational exposure
KW - Thyroid
KW - Thyrotropic hormone
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180311
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170719
STAT- In-Process
CM - Cites: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005
Dec;149(2):329-33 (medline /16601782)
CM - Cites: J Hazard Mater. 2016 Feb 13;303:76-82 (medline /26513566)
CM - Cites: Hum Reprod Update. 1998 May-Jun;4(3):301-9 (medline /9741713)
CM - Cites: Exp Clin Endocrinol Diabetes. 2017 Feb;125(2):79-85 (medline
/27793066)
CM -Cites: Am J Ind Med. 2016 Jul;59(7):583-90 (medline /27094769)
CM -Cites: Arch Intern Med. 1983 Feb;143(2):220-4 (medline /6600605)
CM -Cites: Environ Health Perspect. 2008 Jun;116(6):806-13 (medline /18560538)
CM -Cites: Environ Health Perspect. 2001 Mar;109(3):245-51 (medline /11333185)
CM -Cites: Biometals. 2000 Jun;13(2):187-92 (medline /11016408)
CM -Cites: Thyroid. 1998 Sep;8(9):827-56 (medline /9777756)
CM -Cites: Neurotoxicology. 2007 Sep;28(5):951-6 (medline /17576015)
CM -Cites: Exp Mol Pathol. 1991 Aug;55(1):97-104 (medline /1884772)
CM -Cites: Int J Clin Exp Med. 2015 May 15;8(5):7160-7 (medline /26221254)
CM -Cites: Environ Res. 2009 Oct;109(7):869-73 (medline /19595304)
CM -Cites: Pharmacol Res. 2000 Dec;42(6):599-602 (medline /11058414)
CM -Cites: Environ Health Perspect. 2006 Dec;114(12):1865-71 (medline
/17185277)
CM - Cites: Med Clin North Am. 2012 Mar;96(2):257-68 (medline /22443974)
CM - Cites: Environ Res. 2008 Feb;106(2):195-202 (medline /17988663)
CM - Cites: J Nutr. 2003 May;133(5 Suppl 1):1536S-8S (medline /12730460)
CM - Cites: J Neuroendocrinol. 2008 Jun;20(6):784-94 (medline /18601701)
CM - Cites: Toxicol Sci. 2007 Jul;98(1):75-86 (medline /17283378)
CM - Cites: Biol Trace Elem Res. 2008 Winter;126(1-3):194-203 (medline
/18685812)
CM - Cites: Biol Trace Elem Res. 2008 Winter;126(1-3):1-12 (medline /18716716)
CM - Cites: Med Clin North Am. 2012 Mar;96(2):235-56 (medline /22443973)
CM - Cites: Toxicology. 2006 Nov 10;228(1):77-84 (medline /16982123)
CM - Cites: Curr Opin Endocrinol Diabetes Obes. 2009 Oct;16(5):385-91 (medline
/19625957)
CM - Cites: J Appl Toxicol. 1998 Sep-Oct;18(5):317-20 (medline /9804431)
CM - Cites: Environ Health Perspect. 2008 Feb;116(2):165-72 (medline /18288313)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003
Jan;38(1):129-39 (medline /12635823)
CM - Cites: Arch Environ Health. 2001 Sep-Oct;56(5):449-55 (medline /11777027)
CM - Cites: Environ Pollut. 2015 Oct;205:145-52 (medline /26057477)
CM - Cites: Int J Hyg Environ Health. 2013 Nov;216(6):624-32 (medline
/23044211)
CM - Cites: Br Med Bull. 1999;55(3):658-68 (medline /10746354)
CM - Cites: Int Arch Occup Environ Health. 1998 Oct;71(7):453-8 (medline
/9826077)
CM - Cites: Environ Health Perspect. 2013 Feb;121(2):181-6 (medline /23164649)
CM - Cites: Environ Res. 2006 May;101(1):140-5 (medline /16360141)
CM - Cites: Biol Trace Elem Res. 2008 Winter;126(1-3):49-55 (medline /18685814)
CM - Cites: Environ Health Perspect. 1992 Jul;97:259-67 (medline /1396465)
CM - Cites: Mol Cell Endocrinol. 2005 Oct 20;242(1-2):10-5 (medline /16150534)
CM - Cites: Mutat Res. 2006 Jun;612(3):215-46 (medline /16574468)
CM - Cites: Biol Trace Elem Res. 2007 Oct;119(1):10-8 (medline /17914214)
CM - Cites: Environ Res. 2008 Jul;107(3):380-92 (medline /18313043)
CM - Cites: Scand J Work Environ Health. 1988 Jun;14(3):175-80 (medline
/3393853)
CM - Cites: Toxicol Ind Health. 2015 Dec;31(12):1258-68 (medline /23796758)
DOCNO- medline/28726072

170 - TOXLINE
TI - Ameliorative role of genistein against age-dependent chronic arsenic
toxicity in murine brains via the regulation of oxidative stress and
inflammatory signaling cascades.
AU - Saha S
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata, 700054, India.
AU - Sadhukhan P
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata, 700054, India.
AU - Mahalanobish S
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata, 700054, India.
AU - Dutta S
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata, 700054, India.
AU - Sil PC
AD - Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M,
Kolkata, 700054, India. Electronic address: parames@jcbose.ac.in.
SO - J Nutr Biochem. 2018, May; 55:26-40. [The Journal of nutritional
biochemistry]
AB - Brain is highly prone to oxidative damage due to its huge lipid content
and extensive energy requirements. Exogenous insult in brain via oxidative
injury can lead to severe pathophysiological conditions. Age-dependent
deterioration of normal brain functions is also noteworthy. Genistein, a
polyphenolic isoflavonoid, obtained from the soy plant, is well known to
protect against several diseased conditions. Here, in this study chronic
brain toxicity model was developed using oral administration of arsenic
for 90 days in adult and aged murines. We observed that intraperitoneal
administration of genistein improved the arsenic induced behavioral
abnormalities in the rats. It was also evident from the histopathological
studies that the extent of tissue damage due to arsenic exposure was more
in aged rats compared to the adults. Evaluation of different stress
markers, intracellular ROS level and mitochondrial membrane potential
revealed the involvement of oxidative stress and mitochondrial dysfunction
in inducing brain damage in arsenic exposed murines. It was observed that
genistein can significantly ameliorate the stressed condition in both the
animal groups but the protective effect of genistein was more significant
in the adult animals. The underlying signalling mechanism behind the
cytotoxicity of arsenic was investigated and revealed that genistein
exhibited neuroprotection significantly by modulating the JNK3 mediated
apoptosis, ERK1/2 mediated autophagy and TNF&alpha; associated
inflammatory pathways. Overall study infers that genistein has significant
ameliorative effect of against age-dependent cytotoxicity of arsenic in
murine brains.
KW - Apoptosis
KW - Arsenic
KW - Autophagy
KW - Brain
KW - Genistein
KW - Inflammation
KW - Oxidative stress
LA - eng
IS - 1873-4847 (Electronic)
PT - Journal Article
TA - J Nutr Biochem
YR - 2018
DATE- 20180506
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - The Journal of nutritional biochemistry
EDAT- 20171212
STAT- In-Data-Review
DOCNO- medline/29331881

171 - TOXLINE
TI - Prospective role of indigenous Exiguobacterium profundum PT2 in arsenic
biotransformation and biosorption by planktonic cultures and biofilms.
AU - Saba
AD - The Women University Multan, Multan, Pakistan.
AU - Andreasen R
AD - Department of Geoscience, Aarhus University, Aarhus, Denmark.
AU - Li Y
AD - Bio-Optics Institute, School of Physics and Electronics, Henan University,
Henan, China.
AU - Rehman Y
AD - Department of Microbiology and Molecular Genetics, University of the Punjab,
Lahore, Pakistan.
AU - Ahmed M
AD - Department of Microbiology and Molecular Genetics, University of the Punjab,
Lahore, Pakistan.
AU - Meyer RL
AD - Interdisciplinary Nanoscience Centre, Aarhus University, Aarhus, Denmark.
AU - Sabri AN
AD - Department of Microbiology and Molecular Genetics, University of the Punjab,
Lahore, Pakistan.
SO - J Appl Microbiol. 2018, Feb; 124(2):431-443. [Journal of applied
microbiology]
AB - AIMS: The aim of this study was to analyse arsenic (As) transformation and
biosorption by indigenous As-resistant bacteria both in planktonic and
biofilm modes of growth.
AB - METHODS AND RESULTS: As-resistant bacteria were isolated from industrial
waste water and strain PT2, and identified as Exiguobacterium profundum
through 16S rRNA gene sequencing was selected for further study. As
transformation and biosorption by E. profundumPT2 was determined by
HPLC-ICP-MS analysis. Planktonic cultures reduced
3&middot;73 mmol l-1 As5+ into As3+ from artificial waste water
effluent after 48-h incubation. In case of biosorption, planktonic
cultures and biofilms exhibited 25&middot;2 and
29&middot;4 mg g-1 biomass biosorption, respectively. As
biosorption kinetics followed Freundlich isotherm and pseudo second-order
model. Biofilm formation peaked after 3 days of incubation, and in
the presence of As stress, biofilm formation was significantly affected in
contrast to control (P < 0&middot;05). Homogeneous nature of
mature biofilms with an increased demand of nutrients was revealed by
minimum roughness and maximum surface to biovolume ratio measured through
CLSM analysis.
AB - CONCLUSION: Indigenous As-resistant E. profundumPT2 was found capable of
As transformation and biosorption both in the form of planktonic cultures
and biofilms.
AB - SIGNIFICANCE AND IMPACT OF THE STUDY: Indigenous biofilm forming E.
profundum PT2 revealing As biosorption and biotransformation potential is
presented an eco-friendly and cost-effective source for As remediation
that can be implemented for waste water treatment.
KW - arsenic biotransformation
KW - arsenic resistance
KW - biofilms
KW - bioremediation
KW - wastewater treatment
RN - N712M78A8G
LA - eng
IS - 1365-2672 (Electronic)
PT - Journal Article
TA - J Appl Microbiol
YR - 2018
DATE- 20180514
CI - &copy; 2017 The Society for Applied Microbiology.
DBAN- GENBANK: KX185940: KX185941: KX185938: KX185939
CITO- NLM
CS - England
CSET- IM
FJT - Journal of applied microbiology
EDAT- 20180115
STAT- MEDLINE
DOCNO- medline/29130635

172 - TOXLINE
TI - Transcriptional changes measured in rice roots after exposure to
arsenite-contaminated sediments.
AU - Brinke A
AD - German Federal Institute of Hydrology, Am Mainzer Tor 1, 56068, Koblenz,
Germany. Alexandra.Brinke@bafg.de.
AU - Reifferscheid G
AD - German Federal Institute of Hydrology, Am Mainzer Tor 1, 56068, Koblenz,
Germany.
AU - Klein R
AD - Department VI, Trier University, Biogeography, 54286, Trier, Germany.
AU - Feiler U
AD - German Federal Institute of Hydrology, Am Mainzer Tor 1, 56068, Koblenz,
Germany.
AU - Buchinger S
AD - German Federal Institute of Hydrology, Am Mainzer Tor 1, 56068, Koblenz,
Germany.
SO - Environ Sci Pollut Res Int. 2018, Jan; 25(3):2707-2717. [Environmental
science and pollution research international]
AB - Transcriptional analyses are discussed to provide a deeper understanding
of the molecular mechanisms underlying toxic effects. Thus, they can
complement classic ecotoxicological test methods and potentially allow the
identification of biomarkers associated to the exposure of chemical
stressors and or adverse biological effects. This feasibility study
intended to identify a set of potential gene expression biomarkers for
arsenite-exposure in rice roots that could complement the informative
value of an existing sediment-contact test with rice. A sediment-contact
test with Oryza sativa with the parameters inhibition of root and shoot
elongation as phenotypic endpoints was used as basis. Rice plants were
exposed to arsenite-spiked sediments. Transcriptomic changes in response
to arsenite were observed by means of cDNA-microarray analysis regarding
the whole-transcriptome at two sublethal arsenite concentrations. In order
to identify candidate biomarker genes, differentially expressed genes were
identified. Arsenite-induced differentially expressed genes were
significantly associated with gene ontology (GO)-terms that indicated a
general stress response. Of the differentially expressed genes, five genes
were selected and their expression was measured at seven arsenite
concentrations by means of qPCR in order to obtain their expression
profiles. Three candidate biomarker genes showed a dose-dependent
upregulation, while two showed no clear dose-dependent expression. The
expression of all candidate biomarkers was also assessed in rice plants
grown on two arsenic-contaminated natural sediments, but only one
biomarker gene showed the expected upregulation.
KW - Aquatic plants
KW - Biomarkers
KW - Ecotoxicogenomics
KW - Freshwater toxicology
KW - Sediment toxicity
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180131
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171113
STAT- In-Process
CM - Cites: Plant Physiol. 2000 Mar;122(3):793-801 (medline /10712543)
CM - Cites: Curr Opin Plant Biol. 2009 Jun;12(3):364-72 (medline /19501016)
CM - Cites: Environ Sci Technol. 2013 Aug 6;47(15):8825-34 (medline /23802634)
CM - Cites: J Exp Bot. 2007;58(2):253-65 (medline /17132712)
CM - Cites: Nucleic Acids Res. 2011 Jan;39(Database issue):D1002-4 (medline
/21071405)
CM - Cites: Ecotoxicol Environ Saf. 2015 Apr;114:126-33 (medline /25637747)
CM - Cites: Mol Carcinog. 1999 Mar;24(3):153-9 (medline /10204799)
CM - Cites: Chemosphere. 2009 Feb;74(5):688-702 (medline /18996570)
CM - Cites: Plant J. 2006 Nov;48(4):535-47 (medline /17059409)
CM - Cites: Rice (N Y). 2012 Jul 19;5(1):17 (medline /24279809)
CM - Cites: Environ Sci Pollut Res Int. 2015 Aug;22(16):12664-75 (medline
/25913308)
CM - Cites: Environ Health Perspect. 2003 May;111(6):A338-9 (medline /12760838)
CM - Cites: Aquat Toxicol. 2014 Aug;153:73-88 (medline /24434169)
CM - Cites: Curr Opin Plant Biol. 2002 Jun;5(3):218-23 (medline /11960739)
CM - Cites: Plant Cell Physiol. 2013 Feb;54(2):e6 (medline /23299411)
CM - Cites: Environ Toxicol Chem. 2017 Sep;36(9):2352-2366 (medline /28224655)
CM - Cites: Front Cell Dev Biol. 2017 Jul 18;5:67 (medline /28770198)
CM - Cites: Biochimie. 2006 Nov;88(11):1707-19 (medline /16914250)
CM - Cites: Biotechniques. 2003 Feb;34(2):374-8 (medline /12613259)
CM - Cites: Plant Cell. 2009 Feb;21(2):655-67 (medline /19244140)
CM - Cites: J Exp Bot. 2008;59(8):2267-76 (medline /18453530)
CM - Cites: Trends Plant Sci. 2002 Mar;7(3):106-11 (medline /11906833)
CM - Cites: Biochem Biophys Res Commun. 2006 Jun 30;345(2):646-51 (medline
/16690022)
CM - Cites: Plant Cell Physiol. 2006 Jan;47(1):1-13 (medline /16299003)
CM - Cites: Environ Sci Pollut Res Int. 2017 Apr 8;:null (medline /28391457)
CM - Cites: Genome Biol. 2008;9(2):R40 (medline /18291039)
CM - Cites: Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20853-4 (medline
/21106757)
CM - Cites: Environ Pollut. 2010 Sep;158(9):2999-3010 (medline /20594629)
CM - Cites: Environ Sci Technol. 2014 Mar 18;48(6):3504-12 (medline /24552435)
CM - Cites: Environ Sci Pollut Res Int. 2015 Apr;22(8):5742-50 (medline
/25827791)
CM - Cites: Proteomics. 2008 Sep;8(17):3561-76 (medline /18752204)
CM - Cites: Environ Sci Pollut Res Int. 2015 Nov;22(22):17280-9 (medline
/24994105)
CM - Cites: Reprod Toxicol. 2012 Apr;33(2):245-53 (medline /22326570)
CM - Cites: Nucleic Acids Res. 2015 Jan;43(Database issue):D204-12 (medline
/25348405)
CM - Cites: BMC Genomics. 2009 Apr 14;10:160 (medline /19366437)
CM - Cites: Rice (N Y). 2016 Dec;9(1):60 (medline /27837430)
CM - Cites: BMC Plant Biol. 2014 Apr 16;14:94 (medline /24734953)
DOCNO- medline/29134529

173 - TOXLINE
TI - Nutritional management can assist a significant role in alleviation of
arsenicosis.
AU - Sharma A
AD - Department of Medicinal Chemistry, National Institute of Pharmaceutical
Education and Research, Raebareli, India.
AU - Flora SJS
AD - Department of Medicinal Chemistry, National Institute of Pharmaceutical
Education and Research, Raebareli, India. Electronic address: sjsflora@hotmail.com.
SO - J Trace Elem Med Biol. 2018, Jan; 45:11-20. [Journal of trace elements in
medicine and biology : organ of the Society for Minerals and Trace
Elements (GMS)]
AB - Consumption of arsenic contaminated water causes serious skin disease and
cancer in a significant number of exposed people. Chelating agents,
consider an expensive therapy, are employed in the treatment of arsenic
intoxication. There are reports which suggest that the poorest suffer the
most from arsenicosis. This may be due to improper diet intake, consist of
low protein and micronutrients which increase the vulnerability to
arsenic-related disorders. Several human studies demonstrated the
associations between malnourishment and the development of arsenic-caused
skin lesions, skin cancer and cardiovascular effects. Thus, there is an
urgent need of implementation of mitigation strategies for improving the
health of exposed populations. Nutrition enhances the detoxification
process so food rich in vitamins, protein, antioxidants help in its
detoxification process. Methylation is the detoxification process which
takes place via S-adenosylmethionine (SAM). It is a methyl group donor and
it derived its methyl group from diet. Nutritional intervention thus may
appear as a practical and inexpensive approach. Nutrition provides
protection from toxic effect of arsenic by two ways (i) methylation of As
(ii) antioxidants which provides protection against free radical species.
The governments and NGOs may run awareness programmes in arsenic affected
area regarding prevention and alternate therapy which can decrease the
susceptibility of the exposed population. They could also help in
distributing cheaper, high protein diets particularly to the masses who
cannot afford such foods. Thus, to prevent arsenicosis alternate therapy
and proper nutrition could be the important strategy for alleviating its
toxic effects. This mini review provides an insight on the importance of
nutrition in preventing adverse effect cause by arsenic to suffer
population.
KW - Arsenic
KW - Dietary
KW - Malnutrition
KW - Micronutrients
KW - Toxicity
KW - Vitamins
LA - eng
IS - 1878-3252 (Electronic)
PT - Journal Article
PT - Review
TA - J Trace Elem Med Biol
YR - 2018
DATE- 20171127
CI - Copyright &copy; 2017 Elsevier GmbH. All rights reserved.
CITO- NLM
CS - Germany
FJT - Journal of trace elements in medicine and biology : organ of the Society
for Minerals and Trace Elements (GMS)
EDAT- 20170914
STAT- In-Process
DOCNO- medline/29173466

174 - TOXLINE
TI - A systematic review and meta-analysis of bidirectional effect of arsenic
on ERK signaling pathway.
AU - Li D
AD - Department of Public Health, School of Medicine, Shihezi University, Shihezi,
Xinjiang 832002, P.R. China.
AU - Wei Y
AD - Department of Cardiothoracic Surgery, First Affiliated Hospital, School of
Medicine, Shihezi University, Shihezi, Xinjiang 832000, P.R. China.
AU - Xu S
AD - Department of Public Health, School of Medicine, Shihezi University, Shihezi,
Xinjiang 832002, P.R. China.
AU - Niu Q
AD - Department of Public Health, School of Medicine, Shihezi University, Shihezi,
Xinjiang 832002, P.R. China.
AU - Zhang M
AD - Department of Public Health, School of Medicine, Shihezi University, Shihezi,
Xinjiang 832002, P.R. China.
AU - Li S
AD - Department of Public Health, School of Medicine, Shihezi University, Shihezi,
Xinjiang 832002, P.R. China.
AU - Jing M
AD - Department of Public Health, School of Medicine, Shihezi University, Shihezi,
Xinjiang 832002, P.R. China.
SO - Mol Med Rep. 2018, Mar; 17(3):4422-4432. [Molecular medicine reports]
AB - Arsenic is a toxic metal, which ultimately leads to cell apoptosis. ERK is
considered a key transcriptional regulator of arsenic&#8209;induced
apoptosis. Due to a few controversial issues about arsenic&#8209;mediated
extracellular signal&#8209;regulated MAP kinases (ERK) signaling, a
meta&#8209;analysis was performed. Subgroup analyses demonstrated that
high doses (&ge;2 &micro;mol/l) of arsenic increased the expression
of Ras, ERK, ERK1, ERK2, phosphorylated (p)&#8209;ERK, p&#8209;ERK1, and
p&#8209;ERK2, while low doses ( < 2 &micro;mol/l) decreased the
expression of Ras, ERK1, p&#8209;ERK, and p&#8209;ERK2 when compared to
control groups. Long term exposure ( > 24 h) to arsenic led to
inhibition of expression of ERK1, p&#8209;ERK1, and p&#8209;ERK2, whereas
short&#8209;term exposure (&le;24 h) triggered the expression of
ERK1, ERK2, p&#8209;ERK, p&#8209;ERK1, and p&#8209;ERK2. Furthermore,
normal cells exposed to arsenic exhibited higher production levels of Ras
and p&#8209;ERK. Conversely, exposure of cancer cells to arsenic showed a
lower level of production of Ras and p&#8209;ERK as well as higher level
of p&#8209;ERK1 and p&#8209;ERK2 as compared to control group.
Short&#8209;term exposure of normal cells to high doses of arsenic may
promote ERK signaling pathway. In contrast, long&#8209;term exposure of
cancer cells to low doses of arsenic may inhibit ERK signaling pathway.
This study may be helpful in providing a theoretical basis for the
diverging result of arsenic adverse effects on one hand and therapeutic
mechanisms on the other concerning arsenic&#8209;induced apoptosis.
LA - eng
IS - 1791-3004 (Electronic)
PT - Journal Article
TA - Mol Med Rep
YR - 2018
DATE- 20180227
CITO- NLM
CS - Greece
FJT - Molecular medicine reports
EDAT- 20180105
STAT- In-Process
CM - Cites: PLoS One. 2013 Dec 31;8(12):e85995 (medline /24392034)
CM - Cites: Toxicol Sci. 2014 Apr;138(2):268-77 (medline /24431212)
CM -Cites: Mol Cell Biochem. 2001 Jan;217(1-2):131-6 (medline /11269657)
CM -Cites: Arch Toxicol. 2016 Sep;90(9):2187-200 (medline /26404762)
CM -Cites: Mol Med Rep. 2015 Nov;12(5):7335-43 (medline /26459009)
CM -Cites: Cell Signal. 2006 Feb;18(2):244-55 (medline /15961274)
CM -Cites: Arch Toxicol. 2011 Jun;85(6):565-75 (medline /21533816)
CM -Cites: Pharmacol Res. 2013 Nov;77:11-21 (medline /24004656)
CM -Cites: Neurotoxicol Teratol. 2011 Sep-Oct;33(5):530-7 (medline /21784148)
CM -Cites: Arch Toxicol. 2012 Jun;86(6):879-96 (medline /22488045)
CM -Cites: Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 (medline
/16039940)
CM - Cites: Toxicol Sci. 2016 Jul;152(1):62-71 (medline /27071941)
CM - Cites: Biochem Pharmacol. 2011 Dec 1;82(11):1619-29 (medline /21889928)
CM - Cites: Toxicol Appl Pharmacol. 2011 Oct 1;256(1):44-51 (medline /21798276)
CM - Cites: J Biomed Sci. 2006 Jan;13(1):113-25 (medline /16283431)
CM - Cites: J Cell Physiol. 2011 Mar;226(3):762-8 (medline /20799280)
CM - Cites: Biotechnol Lett. 2014 Oct;36(10 ):1927-36 (medline /24934751)
CM - Cites: Biochem Pharmacol. 2012 Dec 15;84(12):1604-16 (medline /23041229)
CM - Cites: Carcinogenesis. 2004 Jan;25(1):21-8 (medline /14514659)
CM - Cites: Toxicol Sci. 2006 Jan;89(1):164-72 (medline /16207941)
CM - Cites: Toxicol Appl Pharmacol. 2010 Apr 15;244(2):162-73 (medline
/20045430)
CM - Cites: Toxicol Appl Pharmacol. 2015 Jul 1;286(1):36-43 (medline /25804888)
CM - Cites: Arch Toxicol. 2015 Nov;89(11):1971-9 (medline /25199681)
CM - Cites: J Biol Chem. 1999 May 21;274(21):14595-601 (medline /10329651)
CM - Cites: Int J Cancer. 2001 May 15;92 (4):518-26 (medline /11304686)
CM - Cites: Toxicol Lett. 2010 Oct 5;198(2):263-71 (medline /20654705)
CM - Cites: Biochem Biophys Res Commun. 2015 May 29;461(2):243-8 (medline
/25869069)
CM - Cites: Nan Fang Yi Ke Da Xue Xue Bao. 2008 Apr;28(4):639-41 (medline
/18495609)
CM - Cites: Toxicol Lett. 2014 Jan 3;224(1):130-40 (medline /24157283)
CM - Cites: Toxicol Appl Pharmacol. 2010 Feb 1;242(3):247-55 (medline
/19874834)
DOCNO- medline/29328451

175 - TOXLINE
TI - Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to
Inhibit Proteasome-Mediated Degradation of Nrf2.
AU - Jiang J
AU - Tam LM
AU - Wang P
AU - Wang Y
SO - Chem Res Toxicol. 2018, May 21; 31(5):380-387. [Chemical research in
toxicology]
AB - Activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)
antioxidant response signaling pathway is a major mechanism for the
cellular defense against oxidative stress. Arsenite, a widespread
contaminant in drinking water, is known to induce oxidative stress and
activate the Nrf2-dependent signaling pathway through the stabilization of
the Nrf2 protein by inhibiting its ubiquitination via the Cul3-Rbx1-Keap1
(cullin 3, RING-box 1, and Kelch-like ECH-associated protein 1) E3
ubiquitin ligase, and its degradation by the 26S proteasome, though the
underlying mechanism, remains elusive. In the present study, we
demonstrated that arsenite could bind to the RING finger domain of Rbx1 in
vitro and in cells, which led to the suppression of Cul3-Rbx1 E3 ubiquitin
ligase activity, thereby impairing the Nrf2 ubiquitination and activating
the Nrf2-induced antioxidant signaling pathway. Our finding provided novel
insight into arsenic toxicity by uncovering a distinct mechanism
accounting for arsenite-induced Nrf2 activation.
LA - eng
IS - 1520-5010 (Electronic)
PT - Journal Article
TA - Chem Res Toxicol
YR - 2018
DATE- 20180521
CITO- NLM
CS - United States
FJT - Chemical research in toxicology
EDAT- 20180423
STAT- In-Data-Review
DOCNO- medline/29658272

176 - TOXLINE
TI - Health risk assessment of arsenic in Realgar and NiuHuangJieDu Tablets
based on pharmacokinetic study.
AU - Wu X
AD - Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of
Education, Department of Pharmaceutical Analysis, China Pharmaceutical University,
Nanjing 210009, China.
AU - Wu S
AD - Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of
Education, Department of Pharmaceutical Analysis, China Pharmaceutical University,
Nanjing 210009, China.
AU - Liu Y
AD - Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of
Education, Department of Pharmaceutical Analysis, China Pharmaceutical University,
Nanjing 210009, China.
AU - Guan R
AD - Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of
Education, Department of Pharmaceutical Analysis, China Pharmaceutical University,
Nanjing 210009, China.
AU - Liang F
AD - Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of
Education, Department of Pharmaceutical Analysis, China Pharmaceutical University,
Nanjing 210009, China.
AU - Song M
AD - Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of
Education, Department of Pharmaceutical Analysis, China Pharmaceutical University,
Nanjing 210009, China. Electronic address: cqsongmin@sina.com.
AU - Hang T
AD - Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of
Education, Department of Pharmaceutical Analysis, China Pharmaceutical University,
Nanjing 210009, China. Electronic address: hangtj@cpu.edu.cn.
SO - J Trace Elem Med Biol. 2018, Jul; 48:81-86. [Journal of trace elements in
medicine and biology : organ of the Society for Minerals and Trace
Elements (GMS)]
AB - NiuHuangJieDu Tablets (NHJDT), a popular realgar (As4S4) containing
patented traditional Chinese medicine (TCM), is widely used in the
treatment of acute tonsillitis, pharyngitis, periodontitis and mouth
ulcer. However, arsenic is considered as one of the most toxic elements,
leading to growing concerns about the quality and safety of
realgar-containing TCMs recently. In this study, health risk assessment of
arsenic in realgar and NHJDT was conducted through oral administration of
both substances to rats with single and multiple doses, respectively. The
total blood arsenic concentration was used as the health risk indicator
and determined by hydride generation-atomic fluorescence spectrometry
after modified Kjeldahl digestion, and then applied to the pharmacokinetic
study. For single oral dose study in rats, the low, medium, and high doses
of realgar and NHJDT were set equivalent to 1, 5 and 20 times the human
therapeutic dose (1.3&#8239;mg realgar/kg), respectively. Multiple doses
were given at low and high dose levels every 12&#8239;h for seven
consecutive days, respectively. Significant differences in the total blood
arsenic pharmacokinetic profiles were observed between the corresponding
realgar and NHJDT groups. These results indicated that NHJDT significantly
reduced the total blood arsenic exposure present in realgar, and the
detoxification mechanism might be attributed to herb-herb interactions in
NHJDT. However, the accumulation of blood total arsenic was significant
due to the long elimination half-life and high accumulation index in both
realgar and NHJDT groups. Therefore, the potential health risk of arsenic
caused by the administration of realgar-containing TCMs should be taken
into account for excessive or long-term medication. Precautions should be
taken for the clinical application of realgar-containing TCMs.
KW - Arsenic
KW - Health risk assessment
KW - Hydride generation-atomic fluorescence spectrometry
KW - NiuHuangJieDu Tablets
KW - Pharmacokinetics
KW - Realgar
LA - eng
IS - 1878-3252 (Electronic)
PT - Journal Article
TA - J Trace Elem Med Biol
YR - 2018
DATE- 20180518
CI - Copyright &copy; 2018 Elsevier GmbH. All rights reserved.
CITO- NLM
CS - Germany
FJT - Journal of trace elements in medicine and biology : organ of the Society
for Minerals and Trace Elements (GMS)
EDAT- 20180314
STAT- In-Process
DOCNO- medline/29773199

177 - TOXLINE
TI - Arjunolic Acid Improves the Serum Level of Vitamin B12 and Folate in the
Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress.
AU - Maity M
AD - Clinical Nutrition and Dietetics Division (Funded under UGC Innovative
Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India.
AU - Perveen H
AD - Clinical Nutrition and Dietetics Division (Funded under UGC Innovative
Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India.
AU - Dash M
AD - Clinical Nutrition and Dietetics Division (Funded under UGC Innovative
Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India.
AU - Jana S
AD - Clinical Nutrition and Dietetics Division (Funded under UGC Innovative
Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India.
AU - Khatun S
AD - Clinical Nutrition and Dietetics Division (Funded under UGC Innovative
Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India.
AU - Dey A
AD - Clinical Nutrition and Dietetics Division (Funded under UGC Innovative
Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India.
AU - Mandal AK
AD - Chemical Biology Laboratory, Department of Sericulture, Raiganj University,
Uttar Dinajpur, West Bengal, 733134, India.
AU - Chattopadhyay S
AD - Clinical Nutrition and Dietetics Division (Funded under UGC Innovative
Programme), Vidyasagar University, Midnapore, West Bengal, 721102, India.
sandipdoc@mail.vidyasagar.ac.in.
SO - Biol Trace Elem Res. 2018, Mar; 182(1):78-90. [Biological trace element
research]
AB - Continuation of prolonged treatment against arsenicosis with conventional
chelating therapy is a global challenge. The present study was intended to
evaluate the defensive effect of arjunolic acid against arsenic-induced
oxidative stress and female reproductive dysfunction. Wistar strain adult
female rats were given sodium arsenite (10 mg/kg body weight) in
combination with arjunolic acid (10 mg/kg body weight) orally for two
estrous cycles. Electrozymographic analysis explored that arjunolic acid
co-treatment counteracted As3+-induced ROS production in uterine tissue by
stimulating the activities of endogenous enzymatic antioxidants. Arjunolic
acid was able to enhance the protection against mutagenic uterine DNA
breakage, necrosis, and ovarian-uterine tissue damages in arsenicated rats
by improving the ovarian steroidogenesis. The mechanisms might be coupled
with the augmentation of antioxidant defense system, partly through the
elimination of arsenic with the involvement of S-adenosyl methionine pool
where circulating levels of vitamin B12, folic acid, and homocysteine play
critical roles as evidenced from our present investigation.
KW - Arjunolic acid
KW - Arsenic
KW - Folic acid
KW - SAM
KW - Uterine oxidative stress
KW - Vitamin B12
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180211
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170628
STAT- In-Process
DOCNO- medline/28660490

178 - TOXLINE
TI - Arsenic Uptake, Toxicity, Detoxification, and Speciation in Plants:
Physiological, Biochemical, and Molecular Aspects.
AU - Abbas G
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari-61100, Pakistan. g.a92pk@gmail.com.
AU - Murtaza B
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari-61100, Pakistan. behzadmurtaza@ciitvehari.edu.pk.
AU - Bibi I
AD - MARUM and Department of Geosciences, University of Bremen, D-28359 Bremen,
Germany. irshad.niazi81@gmail.com.
AU - Shahid M
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari-61100, Pakistan. muhammadshahid@ciitvehari.edu.pk.
AU - Niazi NK
AD - Southern Cross GeoScience, Southern Cross University, Lismore 2480,
Australia. nabeelkniazi@gmail.com.
AU - Khan MI
AD - Institute of Soil and Environmental Sciences, University of Agriculture
Faisalabad, Faisalabad 38040, Pakistan. khanimran1173@yahoo.com.
AU - Amjad M
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari-61100, Pakistan. drmuhammadamjad@ciitvehari.edu.pk.
AU - Hussain M
AD - Institute of Soil and Environmental Sciences, University of Agriculture
Faisalabad, Faisalabad 38040, Pakistan. munawarhussain452@yahoo.com.
AU - Natasha
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari-61100, Pakistan. natasha564ag@gmail.com.
SO - Int J Environ Res Public Health. 2018, Jan 02. [International journal of
environmental research and public health]
AB - Environmental contamination with arsenic (As) is a global environmental,
agricultural and health issue due to the highly toxic and carcinogenic
nature of As. Exposure of plants to As, even at very low concentration,
can cause many morphological, physiological, and biochemical changes. The
recent research on As in the soil-plant system indicates that As toxicity
to plants varies with its speciation in plants (e.g., arsenite, As(III);
arsenate, As(V)), with the type of plant species, and with other soil
factors controlling As accumulation in plants. Various plant species have
different mechanisms of As(III) or As(V) uptake, toxicity, and
detoxification. This review briefly describes the sources and global
extent of As contamination and As speciation in soil. We discuss different
mechanisms responsible for As(III) and As(V) uptake, toxicity, and
detoxification in plants, at physiological, biochemical, and molecular
levels. This review highlights the importance of the As-induced generation
of reactive oxygen species (ROS), as well as their damaging impacts on
plants at biochemical, genetic, and molecular levels. The role of
different enzymatic (superoxide dismutase, catalase, glutathione
reductase, and ascorbate peroxidase) and non-enzymatic (salicylic acid,
proline, phytochelatins, glutathione, nitric oxide, and phosphorous)
substances under As(III/V) stress have been delineated via conceptual
models showing As translocation and toxicity pathways in plant species.
Significantly, this review addresses the current, albeit partially
understood, emerging aspects on (i) As-induced physiological, biochemical,
and genotoxic mechanisms and responses in plants and (ii) the roles of
different molecules in modulation of As-induced toxicities in plants. We
also provide insight on some important research gaps that need to be
filled to advance our scientific understanding in this area of research on
As in soil-plant systems.
COI - The authors declare no conflict of interest.
KW - arsenic contamination
KW - bioavailability
KW - oxidative stress
KW - phosphate
KW - plant health
KW - potentially toxic elements
KW - reactive oxygen species
LA - eng
IS - 1660-4601 (Electronic)
PT - Journal Article
PT - Review
TA - Int J Environ Res Public Health
YR - 2018
DATE- 20180207
CITO- NLM
CS - Switzerland
FJT - International journal of environmental research and public health
EDAT- 20180102
STAT- In-Data-Review
CM - Cites: Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9931-5 (medline
/18626020)
CM - Cites: J Phys Chem A. 2012 Feb 16;116(6):1596-604 (medline /22257280)
CM - Cites: Biochem J. 1974 Jul;142(1):65-74 (medline /4441373)
CM - Cites: Environ Pollut. 2012 Feb;161:1-7 (medline /22230060)
CM - Cites: ScientificWorldJournal. 2014 Jan 09;2014:921581 (medline /24526924)
CM - Cites: Ecotoxicol Environ Saf. 2009 Feb;72(2):626-34 (medline /18262648)
CM - Cites: Ecotoxicol Environ Saf. 2016 Feb;124:68-73 (medline /26473328)
CM - Cites: Nat Mater. 2017 May;16(5):572-579 (medline /27992420)
CM - Cites: Plant Physiol Biochem. 2016 Jun;103:45-52 (medline /26963899)
CM - Cites: Curr Opin Plant Biol. 2009 Jun;12(3):364-72 (medline /19501016)
CM - Cites: Aquat Toxicol. 2008 Jan 31;86(2):205-15 (medline /18096252)
CM - Cites: Ecotoxicol Environ Saf. 2015 Jul;117:164-73 (medline /25881134)
CM - Cites: Acc Chem Res. 2013 Feb 19;46(2):550-9 (medline /23157446)
CM - Cites: J Hazard Mater. 2015 Apr 28;287:384-91 (medline /25677475)
CM - Cites: Plant Cell. 2010 Jun;22(6):2045-57 (medline /20530755)
CM - Cites: Int J Phytoremediation. 2017 Jul 3;19(7):670-678 (medline
/28084797)
CM - Cites: Int J Phytoremediation. 2017 Nov 2;19(11):1037-1046 (medline
/28463566)
CM - Cites: J Hazard Mater. 2015 May 30;289:219-34 (medline /25726907)
CM - Cites: Annu Rev Phytopathol. 2017 Aug 4;55:85-107 (medline /28504920)
CM - Cites: Mutat Res. 2003 Mar 3;535(2):127-39 (medline /12581530)
CM - Cites: Plant Signal Behav. 2012 Nov;7(11):1456-66 (medline /22951402)
CM - Cites: Front Plant Sci. 2015 May 18;6:340 (medline /26042132)
CM - Cites: Plant Physiol. 2008 Sep;148(1):620-41 (medline /18599647)
CM - Cites: Plant Physiol Biochem. 2013 Dec;73:77-82 (medline /24077292)
CM - Cites: Plant J. 2006 Mar;45(6):917-29 (medline /16507083)
CM - Cites: Toxicol Appl Pharmacol. 2008 Oct 15;232(2):252-7 (medline
/18671993)
CM - Cites: Plant Physiol Biochem. 2014 Jul;80:203-10 (medline /24811675)
CM - Cites: J Environ Sci (China). 2013 Dec 1;25(12):2451-9 (medline /24649677)
CM - Cites: Plant Physiol Biochem. 2009 Jun;47(6):448-55 (medline /19136270)
CM - Cites: Chemosphere. 2005 Oct;61(2):293-301 (medline /16168752)
CM - Cites: Chemosphere. 2013 Jun;92(2):157-70 (medline /23466274)
CM - Cites: Sci Total Environ. 2015 Nov 1;532:803-11 (medline /26136157)
CM - Cites: Environ Sci Pollut Res Int. 2017 Apr;24(10 ):9142-9158 (medline
/28160172)
CM - Cites: Environ Sci Technol. 2011 Sep 1;45(17):7135-42 (medline /21797214)
CM - Cites: Nitric Oxide. 2013 Aug 1;32:13-20 (medline /23545403)
CM - Cites: Plant Physiol. 2005 Jul;138(3):1516-26 (medline /15980200)
CM - Cites: Annu Rev Plant Biol. 2010;61:535-59 (medline /20192735)
CM - Cites: Plant Physiol Biochem. 2012 Aug;57:261-7 (medline /22766395)
CM - Cites: Aquat Toxicol. 2000 Aug 1;50(1-2):1-12 (medline /10930646)
CM - Cites: Environ Health Perspect. 2005 Jun;113(6):A378-86 (medline
/15929879)
CM - Cites: Environ Health Perspect. 2012 Dec;120(12):1733-8 (medline
/23060367)
CM - Cites: J Biol Chem. 1989 May 15;264(14):7761-4 (medline /2542241)
CM - Cites: Biol Trace Elem Res. 2012 Jun;146(3):360-8 (medline /22124861)
CM - Cites: Chemosphere. 2017 Aug;181:44-54 (medline /28419900)
CM - Cites: Plant Cell. 1999 Jun;11(6):1153-64 (medline /10368185)
CM - Cites: Environ Int. 2009 Apr;35(3):485-90 (medline /18793803)
CM - Cites: J Biotechnol. 2013 Jan 10;163(1):1-9 (medline /23108027)
CM - Cites: J Exp Bot. 2002 May;53(372):1255-72 (medline /11997374)
CM - Cites: Environ Int. 2012 Oct 1;46:16-22 (medline /22664651)
CM - Cites: Int J Phytoremediation. 2010 Jul;12(5):487-502 (medline /21166290)
CM - Cites: Plant Physiol Biochem. 2016 Feb;99:86-96 (medline /26741538)
CM - Cites: Trends Plant Sci. 2006 Aug;11(8):392-7 (medline /16839801)
CM - Cites: Sci Rep. 2017 Jun 15;7(1):3592 (medline /28620222)
CM - Cites: Annu Rev Plant Biol. 2007;58:459-81 (medline /17288534)
CM - Cites: Biochim Biophys Acta. 2006 Aug;1758(8):1165-75 (medline /16716251)
CM - Cites: Ecotoxicology. 2013 Apr;22(3):584-96 (medline /23430410)
CM - Cites: New Phytol. 2009;183(2):340-8 (medline /19402874)
CM - Cites: J Hazard Mater. 2015 Nov 15;298:241-51 (medline /26073379)
CM - Cites: Indian J Microbiol. 2011 Jan;51(1):44-7 (medline /22282627)
CM - Cites: Chem Res Toxicol. 2012 Jul 16;25(7):1423-34 (medline /22624971)
CM - Cites: Environ Pollut. 2006 May;141(2):238-46 (medline /16257102)
CM - Cites: Int J Environ Res Public Health. 2015 Oct 05;12(10):12371-90
(medline /26445051)
CM - Cites: Science. 2006 Feb 3;311(5761):622-7 (medline /16456071)
CM - Cites: J Biol Chem. 1983 May 25;258(10):6266-71 (medline /6853484)
CM - Cites: Nitric Oxide. 2009 Jun;20(4):289-97 (medline /19233306)
CM - Cites: Int J Environ Res Public Health. 2017 Jan 19;14 (1): (medline
/28106848)
CM - Cites: Sci Total Environ. 2014 Aug 1;488-489:176-87 (medline /24830930)
CM - Cites: New Phytol. 2009;184(1):41-7 (medline /19656300)
CM - Cites: Plant Physiol Biochem. 2016 Jan;98:119-27 (medline /26686284)
CM - Cites: FEMS Microbiol Rev. 1994 Dec;15(4):355-67 (medline /7848659)
CM - Cites: Plant Physiol Biochem. 2017 Feb;111:144-154 (medline /27930927)
CM - Cites: Sci Total Environ. 2017 Oct 17;:null (medline /29054629)
CM - Cites: J Exp Bot. 2006;57(8):1711-8 (medline /16595577)
CM - Cites: Ecotoxicol Environ Saf. 2015 Feb;112:247-70 (medline /25463877)
CM - Cites: Chem Biol Interact. 2010 Nov 5;188(2):334-9 (medline /20637748)
CM - Cites: Redox Rep. 2017 Nov;22(6):353-360 (medline /28073323)
CM - Cites: Front Physiol. 2012 Jun 06;3:182 (medline /22685440)
CM - Cites: Environ Pollut. 2017 Apr;223:230-237 (medline /28108165)
CM - Cites: J Biol Chem. 1992 Oct 25;267(30):21802-7 (medline /1400489)
CM - Cites: Plant Physiol Biochem. 2013 Oct;71:307-14 (medline /24007815)
CM - Cites: Environ Technol. 2017 May 27;:1-12 (medline /28488470)
CM - Cites: J Plant Physiol. 2009 Oct 15;166(15):1694-9 (medline /19446917)
CM - Cites: Plant Physiol. 2007 Nov;145(3):919-24 (medline /17905867)
CM - Cites: Rev Environ Contam Toxicol. 2013;221:107-27 (medline /23090631)
CM - Cites: Arch Biochem Biophys. 2010 May;497(1-2):13-20 (medline /20193657)
CM - Cites: Toxicology. 2011 May 10;283(2-3):65-87 (medline /21414382)
CM - Cites: ISRN Toxicol. 2013 Jul 22;2013:340925 (medline /23970978)
CM - Cites: Annu Rev Plant Biol. 2004;55:373-99 (medline /15377225)
CM - Cites: New Phytol. 2016 Jan;209(2):762-72 (medline /26010225)
CM - Cites: New Phytol. 2009 Mar;181(4):777-94 (medline /19207683)
CM - Cites: Sci Total Environ. 2017 Apr 15;584-585:631-641 (medline /28131446)
CM - Cites: Curr Environ Health Rep. 2015 Mar;2(1):52-68 (medline /26231242)
CM - Cites: Biomed Res Int. 2016;2016:1423828 (medline /27022603)
CM - Cites: Chemosphere. 2015 Sep;134:1-6 (medline /25880602)
CM - Cites: Chem Biol Interact. 1994 Feb;90(2):139-55 (medline /8156604)
CM - Cites: J Environ Sci (China). 2007;19(6):725-32 (medline /17969647)
CM - Cites: New Phytol. 2005 Dec;168(3):551-8 (medline /16313638)
CM - Cites: J Chem Ecol. 2007 Feb;33(2):251-64 (medline /17216362)
CM - Cites: Chemosphere. 2017 Jul;178:513-533 (medline /28347915)
CM - Cites: Rev Environ Contam Toxicol. 2014;232:1-44 (medline /24984833)
CM - Cites: Free Radic Biol Med. 2011 Jul 15;51(2):257-81 (medline /21554949)
CM - Cites: Plant Physiol. 1990 Aug;93(4):1449-52 (medline /16667638)
CM - Cites: Biochem J. 2008 Mar 15;410(3):621-9 (medline /18039180)
CM - Cites: Proteomics. 2006 Apr;6 Suppl 1:S156-62 (medline /16534746)
CM - Cites: Environ Pollut. 2017 Jul;226:212-218 (medline /28432964)
CM - Cites: J Environ Biol. 2015 Jan;36(1):249-54 (medline /26536800)
CM - Cites: Plant Physiol Biochem. 2017 Mar;112:74-86 (medline /28049059)
CM - Cites: Plant Physiol. 2005 Jun;138(2):790-802 (medline /15908592)
CM - Cites: Environ Geochem Health. 2009 Apr;31 Suppl 1:179-87 (medline
/19142738)
CM - Cites: Plant Physiol. 2009 Aug;150(4):2071-80 (medline /19542298)
CM - Cites: Environ Pollut. 2017 Apr;223:137-145 (medline /28153415)
CM - Cites: Angew Chem Int Ed Engl. 2007;46(15):2594-7 (medline /17352440)
CM - Cites: Plant Physiol Biochem. 2015 Jul;92:11-8 (medline /25900420)
CM - Cites: Biometals. 2014 Apr;27(2):219-28 (medline /24509935)
CM - Cites: Environ Pollut. 2007 Feb;145(3):839-49 (medline /16777300)
CM - Cites: Environ Sci Technol. 2007 Apr 15;41(8):2930-6 (medline /17533860)
CM - Cites: J Hazard Mater. 2013 Nov 15;262:1123-31 (medline /22917495)
CM - Cites: Int J Environ Res Public Health. 2010 Nov;7(11):4050-61 (medline
/21139876)
CM - Cites: Nitric Oxide. 2017 Jul 1;67:39-52 (medline /28456602)
CM - Cites: J Plant Physiol. 2004 Jul;161(7):867-72 (medline /15310076)
CM - Cites: Mutat Res. 2011 Feb 3;719(1-2):29-34 (medline /20970520)
CM - Cites: J Plant Physiol. 2015 Jun 1;181:20-9 (medline /25974366)
CM - Cites: Plant Physiol. 2010 Apr;152(4):2211-21 (medline /20130102)
CM - Cites: Environ Pollut. 2016 Nov;218:111-117 (medline /27552044)
CM - Cites: Plant Cell. 2007 Mar;19(3):1123-33 (medline /17400898)
CM - Cites: Water Res. 2010 Nov;44(19):5789-802 (medline /20684969)
CM - Cites: Bioresour Technol. 2013 May;136:604-9 (medline /23567737)
CM - Cites: J Biol Chem. 1981 Jun 25;256(12):5981-3 (medline /7240187)
CM - Cites: J Plant Physiol. 2006 Sep;163(9):927-36 (medline /16949956)
CM - Cites: Chemosphere. 2007 Jun;68(6):989-1003 (medline /17349677)
CM - Cites: Biol Trace Elem Res. 2014 Jun;158(3):410-21 (medline /24699829)
CM - Cites: Plant Physiol. 2010 Nov;154(3):1505-13 (medline /20870777)
CM - Cites: Sci Rep. 2017 Sep 11;7(1):11231 (medline /28894204)
CM - Cites: Rev Environ Contam Toxicol. 2011;213:113-36 (medline /21541849)
CM - Cites: Environ Int. 2015 Jan;74:221-30 (medline /25454239)
CM - Cites: Ecotoxicol Environ Saf. 2015 Oct;120:59-65 (medline /26036416)
CM - Cites: J Environ Qual. 2003 May-Jun;32(3):767-72 (medline /12809277)
CM - Cites: J Bacteriol. 1995 Apr;177(8):2050-6 (medline /7721697)
CM - Cites: Biol Trace Elem Res. 2011 Jun;140(3):354-67 (medline /20455031)
CM - Cites: J Agric Food Chem. 2008 Sep 24;56(18):8580-7 (medline /18795759)
CM - Cites: Plant Physiol Biochem. 2016 Jul;104:266-77 (medline /27061371)
CM - Cites: J Exp Bot. 2011 Aug;62(12):4391-8 (medline /21586431)
CM - Cites: J Biosci Bioeng. 2014 Jul;118(1):1-9 (medline /24507904)
CM - Cites: Front Microbiol. 2017 Sep 06;8:1706 (medline /28932218)
CM - Cites: Int J Environ Res Public Health. 2013 Apr 12;10(4):1527-46 (medline
/23583964)
CM - Cites: Chemosphere. 2015 Jan;119:697-703 (medline /25150973)
CM - Cites: Plant Physiol Biochem. 2014 Sep;82:76-84 (medline /24907527)
CM - Cites: J Hazard Mater. 2017 May 15;330:68-75 (medline /28212511)
CM - Cites: Annu Rev Plant Biol. 2013;64:429-50 (medline /23451784)
CM - Cites: Ecotoxicol Environ Saf. 2013 Apr;90:28-34 (medline /23321366)
CM - Cites: Sci Total Environ. 2015 Dec 15;538:306-16 (medline /26312405)
CM - Cites: Nitric Oxide. 2014 May 30;39:35-45 (medline /24731839)
CM - Cites: Environ Pollut. 2018 Jan;232:31-41 (medline /28966026)
CM - Cites: Environ Geochem Health. 2016 Dec;38(6):1283-1301 (medline
/26825060)
CM - Cites: Chemosphere. 2016 Apr;149:366-72 (medline /26874625)
CM - Cites: Environ Sci Technol. 2010 Dec 15;44(24):9542-9 (medline /21077666)
CM - Cites: Plant Physiol. 2004 Mar;134(3):1113-22 (medline /15001701)
CM - Cites: Biodegradation. 2018 Feb;29(1):59-69 (medline /29143902)
CM - Cites: Environ Pollut. 2017 Dec 15;234:915-934 (medline /29253832)
CM - Cites: J Exp Bot. 2011 Jun;62(10):3321-38 (medline /21357767)
CM - Cites: Mutat Res. 2009 Mar 31;674(1-2):85-92 (medline /18984063)
CM - Cites: Sci Total Environ. 2015 Feb 1;505:423-34 (medline /25461044)
CM - Cites: New Phytol. 2012 Jul;195(2):356-71 (medline /22578268)
CM - Cites: Ecotoxicol Environ Saf. 2015 May;115:119-25 (medline /25700090)
CM - Cites: Environ Sci Pollut Res Int. 2017 Jul;24(19):16097-16106 (medline
/28537029)
CM - Cites: Ecotoxicology. 2010 Jun;19(5):983-93 (medline /20221688)
CM - Cites: Plant Cell. 2002 Nov;14 (11):2837-47 (medline /12417705)
CM - Cites: Int J Phytoremediation. 2017 Jul 3;19(7):662-669 (medline
/28084804)
CM - Cites: J Phys Chem B. 2014 Jan 9;118(1):37-47 (medline /24328335)
CM - Cites: Free Radic Biol Med. 1998 Sep;25(4-5):576-85 (medline /9741595)
CM - Cites: Clin Chem. 2006 Apr;52(4):601-23 (medline /16484333)
CM - Cites: J Exp Bot. 2002 May;53(372):1331-41 (medline /11997379)
CM - Cites: Plant Physiol Biochem. 2017 Jun;115:163-173 (medline /28371690)
CM - Cites: Int J Mol Sci. 2012;13(3):3145-75 (medline /22489146)
CM - Cites: Transgenic Res. 2012 Dec;21(6):1265-77 (medline /22350764)
CM - Cites: Chemosphere. 2016 Jul;154:283-288 (medline /27058920)
CM - Cites: Plant Physiol Biochem. 2014 Jul;80:278-84 (medline /24813727)
CM - Cites: Environ Health Perspect. 2013 Mar;121(3):295-302 (medline
/23458756)
CM - Cites: Cold Spring Harb Perspect Biol. 2013 Feb 01;5(2):null (medline
/23378590)
CM - Cites: Sci Total Environ. 2015 Sep 15;527-528:552-60 (medline /26006052)
CM - Cites: Ecotoxicology. 2013 May;22(4):656-70 (medline /23479061)
CM - Cites: ScientificWorldJournal. 2015;2015:756120 (medline /25688377)
CM - Cites: J Hazard Mater. 2017 Mar 5;325:36-58 (medline /27915099)
CM - Cites: Biochemistry. 2011 Feb 22;50(7):1128-34 (medline /21214261)
CM - Cites: Environ Sci Pollut Res Int. 2012 Sep;19(8):3506-15 (medline
/22529007)
CM - Cites: Trends Plant Sci. 2004 Dec;9(12):606-13 (medline /15564128)
CM - Cites: Cytoskeleton (Hoboken). 2012 Jan;69(1):1-21 (medline /21976360)
CM - Cites: Physiol Mol Biol Plants. 2015 Jan;21(1):61-9 (medline /25648550)
CM - Cites: Biochim Biophys Acta. 2016 Aug;1864(8):932-44 (medline /26940747)
CM - Cites: J Hazard Mater. 2012 May 30;217-218:141-8 (medline /22459980)
CM - Cites: Environ Sci Technol. 2005 Jul 15;39(14):5241-6 (medline /16082952)
CM - Cites: Mutagenesis. 2007 Jul;22(4):255-61 (medline /17369186)
CM - Cites: Int J Phytoremediation. 2016;18(5):442-9 (medline /26552612)
CM - Cites: Plant Physiol Biochem. 2010 Dec;48(12):909-30 (medline /20870416)
CM - Cites: Ecotoxicol Environ Saf. 2014 Aug;106:126-35 (medline /24836887)
CM - Cites: Annu Rev Plant Biol. 2016 Apr 29;67:489-512 (medline /27128467)
CM - Cites: J Exp Bot. 2005 May;56(415):1335-42 (medline /15781440)
CM - Cites: Environ Pollut. 2012 Jun;165:18-24 (medline /22398017)
CM - Cites: Plant J. 2004 Aug;39(4):629-42 (medline /15272879)
CM - Cites: Plant Physiol. 2011 Jul;156(3):1149-63 (medline /21628630)
CM - Cites: Ecotoxicol Environ Saf. 2011 Jan;74(1):78-84 (medline /20851467)
CM - Cites: Plant Signal Behav. 2012 Jul;7(7):771-8 (medline /22751303)
CM - Cites: Plant Physiol. 2006 Jun;141(2):357-66 (medline /16760488)
CM - Cites: Anal Chem. 2014 Oct 21;86(20):10422-8 (medline /25300934)
CM - Cites: Front Physiol. 2012 Jul 23;3:275 (medline /22934029)
CM - Cites: J Exp Bot. 2002 Dec;53(379):2381-92 (medline /12432030)
CM - Cites: Mutat Res. 2010 Jan;695(1-2):2-8 (medline /19800024)
CM - Cites: Plant Physiol Biochem. 2013 Oct;71:155-63 (medline /23917073)
CM - Cites: Biometals. 2012 Dec;25(6):1155-65 (medline /22886388)
CM - Cites: J Hazard Mater. 2012 Jun 15;219-220:1-12 (medline /22502897)
CM - Cites: Annu Rev Plant Biol. 2008;59:595-624 (medline /18444909)
CM - Cites: Chem Res Toxicol. 2008 May;21(5):1120-4 (medline /18447394)
CM - Cites: Plant Physiol Biochem. 2013 Feb;63:254-61 (medline /23313792)
CM - Cites: C R Biol. 2010 Nov-Dec;333(11-12):814-24 (medline /21146138)
CM - Cites: Rev Environ Contam Toxicol. 2017;241:73-137 (medline /27300014)
CM - Cites: J Hazard Mater. 2012 Nov 30;241-242:307-15 (medline /23062509)
CM - Cites: Front Plant Sci. 2011 Nov 30;2:83 (medline /22645553)
CM - Cites: Front Plant Sci. 2016 Jan 12;6:1272 (medline /26793232)
CM - Cites: Plant J. 2004 Dec;40(6):909-19 (medline /15584956)
DOCNO- medline/29301332

179 - TOXLINE
TI - Chronic arsenicosis and cadmium exposure in wild snowshoe hares (Lepus
americanus) breeding near Yellowknife, Northwest Territories (Canada),
part 1: Evaluation of oxidative stress, antioxidant activities and hepatic
damage.
AU - Amuno S
AD - School of Environment and Sustainability, University of Saskatchewan,
Saskatoon, Canada. Electronic address: soa882@mail.usask.ca.
AU - Jamwal A
AD - Department of Biology, University of Saskatchewan, Saskatoon, Canada.
AU - Grahn B
AD - Western College of Veterinary Medicine, University of Saskatchewan,
Saskatoon, Canada.
AU - Niyogi S
AD - Department of Biology, University of Saskatchewan, Saskatoon, Canada;
Toxicology Centre, University of Saskatchewan, Saskatoon, Canada.
SO - Sci Total Environ. 2018, Mar 15; 618:916-926. [The Science of the total
environment]
AB - Previous gold mining activities and arsenopyrite ore roasting activities
at the Giant mine site (1948 to 2004) resulted in the release of high
amounts of arsenic and trace metals into the terrestrial and aquatic
ecosystems of Yellowknife, Northwest Territories, Canada. While elevated
levels of arsenic has been consistently reported in surface soils and
vegetation near the vicinity of the Giant mine area and in surrounding
locations, systematic studies evaluating the overall health status of
terrestrial small mammals endemic to the area are lacking. The purpose of
this present study was to evaluate and comparatively assess the
biochemical responses and histopathological effects induced by chronic
arsenic and cadmium exposure in wild snowshoe hares breeding near the city
of Yellowknife, specifically around the vicinity of the abandoned Giant
mine site and in reference locations. Analysis included measurement of
total arsenic and cadmium concentration in nails, livers, kidneys, bones,
stomach content of hares, in addition to histopathological evaluation of
hepatic and ocular lesions. Biochemical responses were determined through
measurement of lipid peroxidation levels and antioxidant enzymes
activities (catalase, superoxide dismutase, glutathione peroxidase, and
glutathione disulfide). The results revealed that arsenic concentration
was 17.8 to 48.9 times higher in the stomach content, and in the range of
4 to 23 times elevated in the nails of hares from the mine area compared
to the reference location. Arsenic and cadmium levels were also noted to
be increased in the bones, renal and hepatic tissues of hares captured
near the mine area compared to the reference site. Specifically, hares
from the mine area showed nail cadmium levels that was 2.3 to 17.6 times
higher than those from the reference site. Histopathological examination
of the eyes revealed no specific ocular lesions, such as lens opacity
(cataracts) or conjunctivitis; however, hares from both locations
exhibited hepatic steatosis (fatty liver change). Lipid peroxidation
levels were relatively increased and accompanied with reduced antioxidant
enzyme activities in hares from the mine area compared to the hares from
the reference site. The results of this preliminary study suggest that the
snowshoe hares breeding near the vicinity of Yellowknife, including near
the Giant mine area have been chronically exposed to elevated levels of
arsenic and cadmium, which consequently led to the increased levels of
oxidative stress and perturbation of antioxidant defense system in exposed
animals. The results of this present study constitute the first
observation of chronic arsenicosis in wild small mammal species in Canada.
KW - Arsenic
KW - Arsenicosis
KW - Giant mine
KW - Small mammals
KW - Snowshoe hares
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180118
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20171014
STAT- In-Process
DOCNO- medline/29037475

180 - TOXLINE
TI - Granulated Bog Iron Ores as Sorbents in Passive (Bio)Remediation Systems
for Arsenic Removal.
AU - Debiec K
AD - Laboratory of Environmental Pollution Analysis, Faculty of Biology,
University of Warsaw, Warsaw, Poland.
AU - Rzepa G
AD - Department of Mineralogy, Petrography and Geochemistry, Faculty of Geology,
Geophysics and Environmental Protection, AGH University of Science and Technology,
Krakow, Poland.
AU - Bajda T
AD - Department of Mineralogy, Petrography and Geochemistry, Faculty of Geology,
Geophysics and Environmental Protection, AGH University of Science and Technology,
Krakow, Poland.
AU - Uhrynowski W
AD - Laboratory of Environmental Pollution Analysis, Faculty of Biology,
University of Warsaw, Warsaw, Poland.
AU - Sklodowska A
AD - Laboratory of Environmental Pollution Analysis, Faculty of Biology,
University of Warsaw, Warsaw, Poland.
AU - Krzysztoforski J
AD - Faculty of Chemical and Process Engineering, Warsaw University of Technology,
Warsaw, Poland.
AU - Drewniak L
AD - Laboratory of Environmental Pollution Analysis, Faculty of Biology,
University of Warsaw, Warsaw, Poland.
SO - Front Chem. 2018; 6:54. [Frontiers in chemistry]
AB - The main element of PbRS (passive (bio)remediation systems) are sorbents,
which act as natural filters retaining heavy metals and carriers of
microorganisms involved in water treatment. Thus, the effectiveness of
PbRS is determined by the quality of the (ad)sorbents, which should be
stable under various environmental conditions, have a wide range of
applications and be non-toxic to (micro)organisms used in these systems.
Our previous studies showed that bog iron ores (BIOs) meet these
requirements. However, further investigation of the physical and chemical
parameters of BIOs under environmental conditions is required before their
large-scale application in PbRS. The aim of this study was (i) to
investigate the ability of granulated BIOs (gBIOs) to remove arsenic from
various types of contaminated waters, and (ii) to estimate the application
potential of gBIOs in technologies dedicated to water treatment. These
studies were conducted on synthetic solutions of arsenic and environmental
samples of arsenic contaminated water using a set of adsorption columns
filled with gBIOs. The experiments performed in a static system revealed
that gBIOs are appropriate arsenic and zinc adsorbent. Dynamic adsorption
studies confirmed these results and showed, that the actual sorption
efficiency of gBIOs depends on the adsorbate concentration and is directly
proportional to them. Desorption analysis showed that As-loaded gBIOs are
characterized by high chemical stability and they may be reused for the
(ad)sorption of other elements, i.e., zinc. It was also shown that gBIOs
may be used for remediation of both highly oxygenated waters and
groundwater or settling ponds, where the oxygen level is low, as both
forms of inorganic arsenic (arsenate and arsenite) were effectively
removed. Arsenic concentration after treatment was < 100 &mu;g/L, which
is below the limit for industrial water.
KW - arsenic
KW - bog iron ores (BIOs)
KW - dynamic sorption
KW - in situ remediation
KW - mineral sorbents
KW - water treatment
LA - eng
IS - 2296-2646 (Print)
PT - Journal Article
TA - Front Chem
YR - 2018
DATE- 20180408
CITO- NLM
CS - Switzerland
FJT - Frontiers in chemistry
EDAT- 20180316
STAT- PubMed-not-MEDLINE
CM - Cites: Water Res. 2007 Feb;41(3):591-602 (medline /17173951)
CM - Cites: J Environ Manage. 2010 Nov;91(11):2238-47 (medline /20598797)
CM - Cites: Sci Total Environ. 2016 Oct 1;566-567:76-85 (medline /27213673)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2011;46(13):1491-502 (medline /21961559)
CM - Cites: Water Res. 2005 Aug;39(13):2944-54 (medline /15979686)
CM - Cites: J Hazard Mater. 2008 Mar 1;151(2-3):811-20 (medline /17658682)
CM - Cites: J Environ Manage. 2012 Aug 15;104:93-100 (medline /22484707)
CM - Cites: J Hazard Mater. 2009 Dec 30;172(2-3):1591-6 (medline /19733972)
CM - Cites: Sci Total Environ. 2006 Feb 1;354(2-3):179-90 (medline /16398994)
CM - Cites: J Hazard Mater. 2007 Oct 1;149(1):226-33 (medline /17560022)
CM - Cites: J Hazard Mater. 2008 Jun 15;154(1-3):184-91 (medline /18031930)
CM - Cites: Water Res. 2004 Apr;38(7):1893-9 (medline /15026244)
CM - Cites: Environ Sci Technol. 2001 Jul 1;35(13):2778-84 (medline /11452609)
CM - Cites: Environ Sci Technol. 2016 Aug 2;50(15):8255-62 (medline /27351211)
CM - Cites: Environ Sci Technol. 2007 May 1;41(9):3322-8 (medline /17539544)
CM - Cites: Environ Toxicol Chem. 2009 Mar;28(3):509-15 (medline /18939890)
CM - Cites: Bioresour Technol. 2014 Apr;157:316-26 (medline /24559743)
CM - Cites: J Hazard Mater. 2008 Mar 1;151(2-3):628-35 (medline /17640801)
CM - Cites: Water Sci Technol. 2004;50(8):23-32 (medline /15566183)
CM - Cites: J Hazard Mater. 2007 Apr 2;142(1-2):1-53 (medline /17324507)
CM - Cites: Chemosphere. 2014 Sep;111:243-59 (medline /24997925)
CM - Cites: Water Res. 2005 Oct;39(17):4153-63 (medline /16181656)
CM - Cites: J Environ Manage. 2011 Oct;92(10):2786-93 (medline /21737198)
CM - Cites: Water Res. 2013 Jun 1;47(9):2938-48 (medline /23566332)
CM - Cites: J Hazard Mater. 2009 Mar 15;162(2-3):1007-13 (medline /18614286)
CM - Cites: Toxicol Ind Health. 2016 Jan;32(1):1-6 (medline /23344825)
CM - Cites: Environ Sci Technol. 2006 Oct 1;40(19):6015-20 (medline /17051793)
CM - Cites: Appl Environ Microbiol. 1993 Sep;59(9):2851-6 (medline /8215359)
CM - Cites: Environ Sci Technol. 2008 Jan 1;42(1):147-52 (medline /18350889)
CM - Cites: J Colloid Interface Sci. 2015 Sep 1;453:132-141 (medline /25982936)
CM - Cites: Chemosphere. 2017 Dec;188:99-109 (medline /28881245)
CM - Cites: Environ Geochem Health. 2006 Jun;28(3):197-214 (medline /16607568)
CM - Cites: Water Res. 2015 Mar 15;71:32-41 (medline /25589434)
DOCNO- medline/29616211

181 - TOXLINE
TI - Arsenic impairs insulin signaling in differentiated neuroblastoma SH-SY5Y
cells.
AU - Niyomchan A
AD - Laboratory of Pharmacology, Chulabhorn Research Institute, Thailand;
Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand.
AU - Visitnonthachai D
AD - Laboratory of Pharmacology, Chulabhorn Research Institute, Thailand.
AU - Suntararuks S
AD - Laboratory of Pharmacology, Chulabhorn Research Institute, Thailand.
AU - Ngamsiri P
AD - Laboratory of Pharmacology, Chulabhorn Research Institute, Thailand.
AU - Watcharasit P
AD - Laboratory of Pharmacology, Chulabhorn Research Institute, Thailand;
Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand;
Center of Excellence on Environmental Health and Toxicology (EHT), Office of the
Higher Education Commission, Thailand. Electronic address: Piyajit@cri.or.th.
AU - Satayavivad J
AD - Laboratory of Pharmacology, Chulabhorn Research Institute, Thailand;
Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Rd, Bangkok, 10210, Thailand;
Center of Excellence on Environmental Health and Toxicology (EHT), Office of the
Higher Education Commission, Thailand.
SO - Neurotoxicology. 2018, May; 66:22-31. [Neurotoxicology]
AB - A strong correlation between chronic arsenic exposure and
neuropsychological disorders leads to a growing concern about a potential
risk of arsenic related neurodegeneration. Evidently, brain insulin
signaling contributes to physiological effects, including energy
homeostasis, and learning and memory. Arsenic has been shown to impair
insulin signaling in adipocytes and myocytes, however, this impairment has
not yet been explored in neurons. Here we showed that NaAsO2 caused
significant reduction in basal levels of glucose, plasma membrane glucose
transporter, GLUT 3 and Akt phosphorylation in differentiated human
neuroblastoma SH-SY5Y cells. NaAsO2 significantly decreased
insulin-mediated glucose uptake, as well as GLUT1 and 3 membrane
translocation. Furthermore, the ability of insulin to increase Akt
phosphorylation, a well-recognized insulin signaling response, was
significantly lessened by NaAsO2 treatment. In addition, the classical
tyrosine phosphorylation response of insulin was reduced by NaAsO2, as
evidenced by reduction of insulin-induced tyrosine phosphorylation of
insulin receptor (IR) and insulin receptor substrate-1(IRS-1). Moreover,
NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory
subunit of PI3K causing an imbalance between p110 and p85, the conditions
reported to contribute to insulin sensitivity. Additionally, increment of
IRS-1 interaction with GSK3&beta;, and p85-PI3K were observed in NaAsO2
treated cells. These molecular modulations may be mechanistically
attributed to neuronal insulin signaling impairment by arsenic.
KW - Akt
KW - Arsenic
KW - Insulin
KW - Insulin receptor (IR)
KW - Insulin receptor substrate (IRS)
KW - PI3K
LA - eng
IS - 1872-9711 (Electronic)
PT - Journal Article
TA - Neurotoxicology
YR - 2018
DATE- 20180508
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Neurotoxicology
EDAT- 20180308
STAT- In-Data-Review
DOCNO- medline/29526746

182 - TOXLINE
TI - Arsenic in groundwater of West Bengal, India: A review of human health
risks and assessment of possible intervention options.
AU - Bhowmick S
AD - Kolkata Zonal Center, CSIR-National Environmental Engineering Research
Institute (NEERI), Kolkata, West Bengal 700107, India. Electronic address:
subhamoy081984@gmail.com.
AU - Pramanik S
AD - Kolkata Zonal Center, CSIR-National Environmental Engineering Research
Institute (NEERI), Kolkata, West Bengal 700107, India.
AU - Singh P
AD - Kolkata Zonal Center, CSIR-National Environmental Engineering Research
Institute (NEERI), Kolkata, West Bengal 700107, India.
AU - Mondal P
AD - Ceramic Membrane Division, CSIR-Central Glass and Ceramic Research Institute
(CGCRI), Raja S.C. Mullick Road, Kolkata 700032, India.
AU - Chatterjee D
AD - Department of Chemistry, University of Kalyani, Kalyani, Nadia, West Bengal
741235, India.
AU - Nriagu J
AD - Department of Environmental Health Sciences, School of Public Health,
University of Michigan, 109 Observatory Street, Ann Arbor, MI 48109-2029, USA.
SO - Sci Total Environ. 2018, Jan 15; 612:148-169. [The Science of the total
environment]
AB - This paper reviews how active research in West Bengal has unmasked the
endemic arsenism that has detrimental effects on the health of millions of
people and their offspring. It documents how the pathways of exposure to
this toxin/poison have been greatly expanded through intensive application
of groundwater in agriculture in the region within the Green Revolution
framework. A goal of this paper is to compare and contrast the
similarities and differences in arsenic occurrence in West Bengal with
those of other parts of the world and assess the unique socio-cultural
factors that determine the risks of exposure to arsenic in local
groundwater. Successful intervention options are also critically reviewed
with emphasis on integrative strategies that ensure safe water to the
population, proper nutrition, and effective ways to reduce the transfer of
arsenic from soil to crops. While no universal model may be suited for the
vast areas of the world affected with by natural contamination of
groundwater with arsenic, we have emphasized community-specific
sustainable options that can be adapted. Disseminating scientifically
correct information among the population coupled with increased community
level participation and education are recognized as necessary adjuncts for
an engineering intervention to be successful and sustainable.
KW - Biomarkers
KW - Groundwater
KW - Mitigation
KW - Rice
KW - Sustainable management
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
PT - Review
TA - Sci Total Environ
YR - 2018
DATE- 20180103
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20170901
STAT- In-Process
DOCNO- medline/28850835

183 - TOXLINE
TI - Arsenic biokinetics and bioavailability in deposit-feeding clams and
polychaetes.
AU - Zhang W
AD - Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong
Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of
Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; Division of Life
Science, Hong Kong University of Science and Technology (HKUST), Clearwater Bay,
Kowloon, Hong Kong.
AU - Wang WX
AD - Division of Life Science, Hong Kong University of Science and Technology
(HKUST), Clearwater Bay, Kowloon, Hong Kong; Marine Environmental Laboratory, HKUST
Shenzhen Research Institute, Shenzhen 518057, China. Electronic address:
wwang@ust.hk.
SO - Sci Total Environ. 2018, Mar; 616-617:594-601. [The Science of the total
environment]
AB - In the present study, the arsenic (As) biokinetics and bioavailability in
two deposit-feeding invertebrates (clams Gafrarium tumidum and polychaetes
Nereis succinea) were quantified. Radiotracer techniques were applied to
measure the dissolved uptake rate, dietary assimilation efficiency and
efflux of As by the clams and polychaetes. Simultaneously, arsenic species
analysis was conducted to examine the As biotransformation following
dietary uptake. The radiotracer results showed that the uptake rate
constant and efflux rate constant were 0.068L/g/d and 0.07d-1, and
0.173L/g/d and 0.09d-1, in the clams and polychaetes, respectively.
Sediments labeled for different times (1.5-60 d) with different
inorganic/organic As percentages led to diverse assimilation efficiencies
of As (35.1-56.1% in the clams, and 51.6-72.6% in the polychaetes).
Modeling calculations showed that sediment was a significant source for As
bioaccumulation in the two deposit-feeders. After feeding on the spiked
sediments, inorganic As (75.6%) was initially the predominant form, but
arsenobetaine (AsB) became the predominant compound ( > 90%) in the clams
and polychaetes during depuration, suggesting biotransformation of
inorganic As. Combined with the biokinetics and biotransformation
measurements, we showed that AsB was more efficiently assimilated and
tended to be accumulated, whereas As(III) was less efficiently assimilated
and more rapidly eliminated by the two invertebrates. This study
demonstrated that As speciation in the sediments as a significant source
for As bioaccumulation caused different bioavailability in deposit-feeding
clams and polychaetes.
KW - Arsenic
KW - Bioavailability
KW - Biokinetics
KW - Biotransformation
KW - Deposit-feeding invertebrates
RN - N712M78A8G
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180515
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
STAT- MEDLINE
DOCNO- medline/29100693

184 - TOXLINE
TI - Treatment of Arsenite Intoxication-Induced Peripheral Vasculopathy with
Mesenchymal Stem Cells.
AU - Chiang YH
AD - Department of Orthopaedics, National Yang-Ming University Hospital, Yilan
260, Taiwan. chiang340@gmail.com.
AU - Lin CC
AD - Department of Biotechnology and Animal Science, National Yilan University,
Yilan 260, Taiwan. Lincc@niu.edu.tw.
AU - Chen YC
AD - Department of Pathology, National Yang-Ming University Hospital, Yilan 260,
Taiwan. 999liquor999@gmail.com.
AU - Lee OK
AD - Department of Orthopaedics and Traumatology, Taipei Veterans General
Hospital, Taipei 11217, Taiwan. DAV47@tpech.gov.tw.
SO - Int J Mol Sci. 2018, Mar 29. [International journal of molecular sciences]
AB - Arsenite (As), a notorious toxic metal, is ubiquitously distributed in the
earth and poses a serious threat to human health. Histopathological
lesions of As intoxication are known as thromboangiitis obliterans, which
are resistant to current treatment and often lead to lower limb
amputation. In this study, we attempt to find that treatment with
mesenchymal stem cells (MSCs) may be effective for As-induced
vasculopathy. We first conducted an in vitro study with a co-culture
system containing human MSCs and human umbilical vein endothelial cells
(HUVECs) and treated individual and co-cultured cells with various
concentrations of arsenite. We also designed an in vivo study in which
Sprague Dawley (SD) rats received periodic intraperitoneal (IP) injections
of 16 ppm arsenite for 12 weeks. MSCs were harvested from BALB/c mice that
were transplanted via tail vein injection. We found that there was
significantly higher cellular viability in human mesenchymal stem cells
(hMSCs) than in HUVECs under concentrations of arsenite between 15 and 25
&mu;M. The Annexin V apoptosis assay further confirmed this finding.
Cytokine array assay for As-conditioned media revealed an elevated
vascular endothelial growth factor (VEGF) level secreted by MSCs, which is
crucial for HUVEC survival and was evaluated by an siRNA VEGF knockdown
test. In the in vivo study, we demonstrated early apoptotic changes in the
anterior tibial vessels of As-injected SD rats with a Terminal
deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, but
these apoptotic changes were less frequently observed upon MSCs
transplantation, indicating that the cytoprotective effect of MSCs
successfully protected against As-induced peripheral vasculopathy. The
feasibility of MSCs to treat and /or prevent the progression of As-induced
vasculopathy is justified. Further clinical studies are required to
demonstrate the therapeutic efficacy of MSCs in patients suffering from As
intoxication with vasculopathy.
COI - The authors declare no conflict of interest.
KW - arsenite
KW - mesenchymal stem cells
KW - peripheral vascular disease
LA - eng
IS - 1422-0067 (Electronic)
PT - Journal Article
TA - Int J Mol Sci
YR - 2018
DATE- 20180611
CITO- NLM
CS - Switzerland
FJT - International journal of molecular sciences
EDAT- 20180329
STAT- In-Process
CM - Cites: Atherosclerosis. 2010 Feb;208(2):461-6 (medline /19720375)
CM - Cites: Atherosclerosis. 2008 Jul;199(1):12-8 (medline /18367191)
CM - Cites: Toxicol Sci. 2008 Apr;102(2):207-18 (medline /17947343)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev.
2005;23(1):55-74 (medline /16291522)
CM - Cites: Nat Med. 2003 Jun;9(6):702-12 (medline /12778169)
CM - Cites: J Cell Biochem. 2006 Aug 1;98(5):1076-84 (medline /16619257)
CM - Cites: Cell Stem Cell. 2008 Sep 11;3(3):301-13 (medline /18786417)
CM - Cites: J Biol Chem. 1998 Nov 13;273(46):30336-43 (medline /9804796)
CM - Cites: J Cell Mol Med. 2010 Sep;14(9):2190-9 (medline /20716123)
CM - Cites: Cytotherapy. 2014 May;16(5):579-85 (medline /24113425)
CM - Cites: J Cell Physiol. 2009 Jun;219(3):563-71 (medline /19170074)
CM - Cites: PLoS One. 2013;8(1):e54747 (medline /23359810)
CM - Cites: Am J Blood Res. 2013 Aug 19;3(3):225-38 (medline /23997985)
CM - Cites: Proc Natl Acad Sci U S A. 1995 May 23;92(11):4857-61 (medline
/7761413)
CM - Cites: Biomaterials. 2014 Apr;35(11):3607-17 (medline /24462361)
CM - Cites: Nat Med. 1999 Mar;5(3):309-13 (medline /10086387)
CM - Cites: Rev Environ Health. 2011;26(1):71-8 (medline /21714384)
CM - Cites: Cell Transplant. 2009;18(3):371-80 (medline /19500466)
CM - Cites: Nature. 2002 Jul 4;418(6893):41-9 (medline /12077603)
CM - Cites: Diabetes. 2013 Apr;62(4):1041-53 (medline /23520284)
CM - Cites: Am J Physiol Renal Physiol. 2010 Dec;299(6):F1288-98 (medline
/20844023)
CM - Cites: PLoS One. 2014 Sep 08;9(9):e107001 (medline /25198551)
CM - Cites: Int J Hyg Environ Health. 2001 Mar;203(3):249-62 (medline
/11279822)
CM - Cites: Mol Ther. 2002 Jul;6(1):127-33 (medline /12095313)
CM - Cites: N Engl J Med. 2010 Jul 8;363(2):147-55 (medline /20573916)
CM - Cites: Drug Discov Today. 2008 Mar;13(5-6):268-74 (medline /18342804)
CM - Cites: Environ Toxicol. 2008 Apr;23(2):263-8 (medline /18214907)
CM - Cites: Toxicol Sci. 2011 Jul;122(1):211-21 (medline /21512104)
CM - Cites: PLoS One. 2014 Oct 31;9(10):e109916 (medline /25360519)
CM - Cites: Toxicol Appl Pharmacol. 2010 May 1;244(3):263-72 (medline
/20083129)
CM -Cites: Endocrinology. 2008 May;149(5):2433-42 (medline /18187555)
CM -Cites: Annu Rev Pharmacol Toxicol. 2007;47:243-62 (medline /17002598)
CM -Cites: Science. 1999 Apr 2;284(5411):143-7 (medline /10102814)
CM -Cites: Environ Health Perspect. 2001 Oct;109(10):1011-7 (medline
/11675266)
CM - Cites: J Vasc Surg. 2015 Sep;62(3):673-80 (medline /26304481)
CM - Cites: Nat Med. 2003 Jun;9(6):653-60 (medline /12778163)
CM - Cites: Cell Stem Cell. 2012 Jun 14;10(6):709-16 (medline /22704511)
CM - Cites: Transplantation. 1968 Mar;6(2):230-47 (medline /5654088)
CM - Cites: J Prev Med Public Health. 2014 Sep;47(5):253-7 (medline /25284196)
CM - Cites: Oncotarget. 2015 Oct 13;6(31):30453-71 (medline /26421711)
CM - Cites: Stem Cells. 2007 Sep;25(9):2363-70 (medline /17540857)
CM - Cites: Toxicol In Vitro. 2016 Sep;35:188-201 (medline /27327130)
CM - Cites: Transfus Med Hemother. 2008;35(4):279-285 (medline /21512643)
DOCNO- medline/29596344

185 - TOXLINE
TI - Myco-phytoremediation of arsenic- and lead-contaminated soils by
Helianthus annuus and wood rot fungi, Trichoderma sp. isolated from
decayed wood.
AU - Govarthanan M
AD - Department of Energy and Environmental System Engineering, University of
Seoul, Seoul 02504, Republic of Korea; PG &amp; Research Department of
Biotechnology, Mahendra Arts and Science College (Autonomous), Kalippatti, Namakkal
637501, Tamil Nadu, India. Electronic address: gova.muthu@gmail.com.
AU - Mythili R
AD - PG &amp; Research Department of Biotechnology, Mahendra Arts and Science
College (Autonomous), Kalippatti, Namakkal 637501, Tamil Nadu, India.
AU - Selvankumar T
AD - PG &amp; Research Department of Biotechnology, Mahendra Arts and Science
College (Autonomous), Kalippatti, Namakkal 637501, Tamil Nadu, India.
AU - Kamala-Kannan S
AD - Division of Biotechnology, Advanced Institute of Environment and Bioscience,
College of Environmental and Bioresource Sciences, Chonbuk National University,
Iksan 570 752, South Korea.
AU - Kim H
AD - Department of Energy and Environmental System Engineering, University of
Seoul, Seoul 02504, Republic of Korea. Electronic address: h_kim@uos.ac.kr.
SO - Ecotoxicol Environ Saf. 2018, Apr 30; 151:279-284. [Ecotoxicology and
environmental safety]
AB - In the present study, Helianthus annuus grown in arsenic- (As) and lead-
(Pb) contaminated soil were treated with plant-growth promoting fungi
Trichoderma sp. MG isolated from decayed wood and assessed for their
phytoremediation efficiency. The isolate MG exhibited a high tolerance to
As (650mg/L) and Pb (500mg/L), and could remove > 70% of metals in
aqueous solution with an initial concentration of 100mg/L each. In
addition, the isolate MG was screened for plant-growth-promoting factors
such as siderophores, 1-aminocyclopropane-1-carboxylic acid (ACC)
deaminase, indole acetic acid (IAA) synthesis, and phosphate
solubilisation. Phytoremediation studies indicated that treatment of H.
annuus with the isolate MG had the maximum metal-accumulation in shoots
(As; 67%, Pb; 59%). Furthermore, a significant increase in the soil
extracellular enzyme-activities was observed in myco-phytoremediated
soils. The activities of phosphatase (35 U/g dry soil), dehydrogenase
(41mg TPF/g soil), cellulase (37.2mg glucose/g/2h), urease (55.4mgN/g
soil/2h), amylase (49.3mg glucose/g/2h) and invertase (45.3mg
glucose/g/2h) significantly increased by 12%, 14%, 12%, 22%, 19% and 14%
in As contaminated soil, respectively. Similarly, the activities of
phosphatase (31.4U/g dry soil), dehydrogenase (39.3mg TPF/g soil),
cellulase (37.1mg glucose/g/2h), urease (49.8mgN/g soil/2h), amylase
(46.3mg glucose/g/2h), and invertase (42.1mg glucose/g/2h) significantly
increased by 11%, 15%, 11%, 18%, 20% and 14% in Pb contaminated soil,
respectively. Obtained results indicate that the isolate MG could be a
potential strain for myco-phytoremediation of As and Pb contaminated soil.
KW - Arsenic
KW - Helianthus annuus
KW - Phytoremediation
KW - Soil enzymes
KW - Trichoderma
RN - 2P299V784P
RN - 3K9EJ633GL
RN - 6U1S09C61L
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180530
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180203
STAT- MEDLINE
DOCNO- medline/29407561

186 - TOXLINE
TI - Influence of the Chemical Form of Antimony on Soil Microbial Community
Structure and Arsenite Oxidation Activity.
AU - Kataoka T
AD - Center for Marine Environmental Studies (CMES), Ehime University.
AU - Mitsunobu S
AD - Department of Bioresources, Faculty of Agriculture, Ehime University.
AU - Hamamura N
AD - Department of Biology, Faculty of Science, Kyushu University.
SO - Microbes Environ. 2018, Jun 09. [Microbes and environments]
AB - In the present study, the influence of the co-contamination with various
chemical forms of antimony (Sb) with arsenite (As[III]) on soil microbial
communities was investigated. The oxidation of As(III) to As(V) was
monitored in soil columns amended with As(III) and three different
chemical forms of Sb: antimony potassium tartrate (Sb[III]-tar),
antimony(III) oxide (Sb2O3), and potassium antimonate (Sb[V]). Soil
microbial communities were examined qualitatively and quantitatively using
16S rDNA- and arsenite oxidase gene (aioA)-targeted analyses. Microbial
As(III) oxidation was detected in all soil columns and 90-100% of added
As(III) (200 &mu; mol L-1) was oxidized to As(V) in 9 d, except in the
Sb(III)-tar co-amendments that only oxidized 30%. 16S rDNA- and
aioA-targeted analyses showed that the presence of different Sb chemical
forms significantly affected the selection of distinct As(III)-oxidizing
bacterial populations. Most of the 16S rRNA genes detected in soil columns
belonged to Betaproteobacteria and Gammaproteobacteria, and some sequences
were closely related to those of known As(III) oxidizers. Co-amendments
with Sb(III)-tar and high concentrations of Sb2O3 significantly increased
the ratios of aioA-possessing bacterial populations, indicating the
enrichment of As(III) oxidizers resistant to As and Sb toxicity. Under Sb
co-amendment conditions, there was no correlation between aioA gene
abundance and the rates of As(III) oxidation. Collectively, these results
demonstrated that the presence of different Sb chemical forms imposed a
strong selective pressure on the soil bacterial community and, thus, the
co-existing metalloid is an important factor affecting the redox
transformation of arsenic in natural environments.
KW - advective flow cultivation
KW - antimony
KW - arsenite oxidase gene (aio)
KW - multiple metalloid contamination
KW - soil microbial community
LA - eng
IS - 1347-4405 (Electronic)
PT - Journal Article
TA - Microbes Environ
YR - 2018
DATE- 20180611
CITO- NLM
CS - Japan
FJT - Microbes and environments
EDAT- 20180609
STAT- Publisher
DOCNO- medline/29887548

187 - TOXLINE
TI - Vermiremediation of metal(loid)s via Eichornia crassipes phytomass
extraction: A sustainable technique for plant amelioration.
AU - Majumdar A
AD - Earth and Environmental Science Research Laboratory, Department of Earth
Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur,
West Bengal 741246, India.
AU - Barla A
AD - Earth and Environmental Science Research Laboratory, Department of Earth
Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur,
West Bengal 741246, India.
AU - Upadhyay MK
AD - Institute of Environment &amp; Sustainable Development, Banaras Hindu
University, Varanasi 221005, India.
AU - Ghosh D
AD - Department of Environmental Science, University of Calcutta, Ballygunge
Circular Road, Kolkata 700019, India.
AU - Chaudhuri P
AD - Department of Environmental Science, University of Calcutta, Ballygunge
Circular Road, Kolkata 700019, India.
AU - Srivastava S
AD - Institute of Environment &amp; Sustainable Development, Banaras Hindu
University, Varanasi 221005, India.
AU - Bose S
AD - Earth and Environmental Science Research Laboratory, Department of Earth
Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur,
West Bengal 741246, India. Electronic address: sutaparai@gmail.com.
SO - J Environ Manage. 2018, Aug 15; 220:118-125. [Journal of environmental
management]
AB - Eichhornia crassipes (water hyacinth), imparts deficiency of soluble
arsenic and other toxic metal (loid)s through rhizofiltration and
phytoaccumulation. Without proper management strategy, this
phytoremediation of metal (loid)s might fail and get reverted back to the
environment, contaminating the nearby water bodies. This study, focused on
bio-conversion of phytoremediating hyacinths, spiked with 100 times and
greater arsenic, lead and cadmium concentrations than the average water
contamination, ranging in 58.81&#8239;&plusmn;&#8239;0.394,
16.74&#8239;&plusmn;&#8239;0.367,
12.18&#8239;&plusmn;&#8239;0.153&#8239;mg Kg-1arsenic,
18.95&#8239;&plusmn;&#8239;0.212, 9.53&#8239;&plusmn;&#8239;0.054,
6.83&#8239;&plusmn;&#8239;0.306&#8239;mg&#8239;kg-1 lead and
2.79&#8239;&plusmn;&#8239;0.033, 1.39&#8239;&plusmn;&#8239;0.025,
0.92&#8239;&plusmn;&#8239;0.045&#8239;mg&#8239;kg-1 cadmium, respectively
in root, shoot and leaves, proving it's phytoaccumulation capacity. Next,
these hyacinths has been used as a source of organic supplement for
preparing vermicompost using Eisenia fetida following analysis of total
metal content and sequential extraction. Control soil was having
134.69&#8239;&plusmn;&#8239;2.47&#8239;mg&#8239;kg-1 arsenic in compare to
44.6&#8239;&plusmn;&#8239;0.91&#8239;mg&#8239;kg-1 at premature stage of
compost to 23.9&#8239;&plusmn;&#8239;1.55&#8239;mg&#8239;kg-1 at mature
compost indicating sustainable fate of phytoremediated vermicompost. This
vermiremediation of arsenic and other toxic elements, restricted the
bioavailability of soil pollutants. Furthermore, processed compost amended
as organic fertilizer, growing chickpea, coriander, tomato and chilli
plant, resulted in negligible metal(loid)s in treated samples, enhancing
also plant's growth and production.
KW - Arsenic
KW - Bio-conversion
KW - Phytoaccumulation
KW - Plant growth promotion
KW - Vermiremediation
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180531
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180526
STAT- In-Process
DOCNO- medline/29775821

188 - TOXLINE
TI - Provenance, prevalence and health perspective of co-occurrences of
arsenic, fluoride and uranium in the aquifers of the Brahmaputra River
floodplain.
AU - Das N
AD - Department of Environmental Science, Tezpur University, Napaam 784028, Assam,
India.
AU - Das A
AD - Department of Environmental Science, Tezpur University, Napaam 784028, Assam,
India.
AU - Sarma KP
AD - Department of Environmental Science, Tezpur University, Napaam 784028, Assam,
India.
AU - Kumar M
AD - Department of Earth Sciences, Indian Institute of Technology Gandhinagar,
382355, Gujarat, India. Electronic address: manish.env@gmail.com.
SO - Chemosphere. 2018, Mar; 194:755-772. [Chemosphere]
AB - The present work focuses on understanding the provenance, prevalence and
health perspective of As and F- along with possible co-occurrence of
uranium (U) in the aquifers of the Brahmaputra floodplains (BFP), India.
Groundwater (n = 164) and sediment samples (n = 5)
were obtained from the upper, middle and lower BFP. Energy dispersive
spectroscopy (EDX) revealed the presence of As, U and Fe in the sediment
matrix. Regression analysis showed a weaker relationship between As and F-
co-occurrence. Hierarchical cluster analysis (HCA) and principal component
analysis (PCA) suggested reductive dissolution of Fe (hydr)oxides
responsible for As release in the BFP, especially in the upper and lower
BFP. Bicarbonate appeared to compete with As oxyanions for adsorption on
positively charged surfaces leading to As release. Arsenic desorption in
presence of PO43-, F- and HCO3- at elevated pH appeared greatest in the
upper BFP, suggesting the highest potential for co-occurrence.
Co-occurrence, were mainly in isolated aquifers of the upper BFP owing to
desorption of adsorbed As and F- from Fe (hydr)oxides at higher pH.
Weathering and dissolution of clay minerals in the upper BFP, and
competitive desorption in presence of HCO3- and PO43- in the middle and
lower BFP, respectively, explain variabilities in F- release. Amorphous Fe
(hydr)oxides like ferrihydrite act as sinks of U. Concentrations of As and
F- will likely increase in the future as projected from the saturated
levels of goethite and ferrihydrite. Hazard indices (HI) revealed that
children (3-8 years) were at greater health risk than adults.
KW - Arsenic
KW - Brahmaputra
KW - Fluoride
KW - Groundwater
KW - Health
KW - Uranium
RN - 1310-14-1
RN - 4OC371KSTK
RN - 87PZU03K0K
RN - N712M78A8G
RN - Q80VPU408O
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180228
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171205
STAT- MEDLINE
DOCNO- medline/29247935

189 - TOXLINE
TI - Arbuscular mycorrhizal fungi alleviate arsenic toxicity to Medicago sativa
by influencing arsenic speciation and partitioning.
AU - Li J
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, No. 18, Shuangqing Road,
Haidian District, Beijing 100085, China; University of Chinese Academy of Sciences,
Beijing 100049, China.
AU - Sun Y
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, No. 18, Shuangqing Road,
Haidian District, Beijing 100085, China; University of Chinese Academy of Sciences,
Beijing 100049, China.
AU - Jiang X
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, No. 18, Shuangqing Road,
Haidian District, Beijing 100085, China.
AU - Chen B
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, No. 18, Shuangqing Road,
Haidian District, Beijing 100085, China; University of Chinese Academy of Sciences,
Beijing 100049, China.
AU - Zhang X
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, No. 18, Shuangqing Road,
Haidian District, Beijing 100085, China. Electronic address: xinzhang@rcees.ac.cn.
SO - Ecotoxicol Environ Saf. 2018, Aug 15; 157:235-243. [Ecotoxicology and
environmental safety]
AB - In a pot experiment, Medicago sativa inoculated with/without arbuscular
mycorrhizal (AM) fungus Rhizophagus irregularis were grown in four levels
(0, 10, 25, and 75&#8239;mg/kg) of arsenic (As)-polluted soil to
investigate the influences of AM symbiosis on plant As tolerance. The
results showed that mycorrhizal inoculation significantly increased plant
biomass, while As addition decreased mycorrhizal colonization and hyphal
length density. Mycorrhizal inoculation dramatically improved plant
phosphorus (P) nutrition, restricted As uptake and retained more As in
roots by upregulating the expression of the AM-induced P transporter gene
MsPT4 and the metallothionein gene MsMT2. High soil As content
downregulated MsPT4 expression. Dimethylarsenic acid (DMA) was detected
only in the shoots of mycorrhizal plants, indicating that AM fungi likely
play an essential role in As detoxification by biological methylation. The
present investigation allowed deeper insights into the As detoxification
mechanisms of AM associations and demonstrated the important role of AM
fungi in plant resistance under As-contaminated conditions.
KW - Arbuscular mycorrhiza
KW - As partitioning
KW - As speciation
KW - Gene expression
KW - Medicago sativa
KW - P acquisition
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180424
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180403
STAT- In-Process
DOCNO- medline/29625397

190 - TOXLINE
TI - Pathological and Clinical Pathological Changes Induced by Four-week,
Repeated-dose, Oral Administration of the Wood Preservative Chromated
Copper Arsenate in Wistar Rats.
AU - Takahashi N
AD - 1 The Institute of Environmental Toxicology, Joso-shi, Ibaraki, Japan.
AU - Yoshida T
AD - 2 Laboratory of Veterinary Pathology, Tokyo University of Agriculture and
Technology, Fuchu-shi, Tokyo, Japan.
AU - Kojima S
AD - 1 The Institute of Environmental Toxicology, Joso-shi, Ibaraki, Japan.
AU - Yamaguchi S
AD - 1 The Institute of Environmental Toxicology, Joso-shi, Ibaraki, Japan.
AU - Ohtsuka R
AD - 1 The Institute of Environmental Toxicology, Joso-shi, Ibaraki, Japan.
AU - Takeda M
AD - 1 The Institute of Environmental Toxicology, Joso-shi, Ibaraki, Japan.
AU - Kosaka T
AD - 1 The Institute of Environmental Toxicology, Joso-shi, Ibaraki, Japan.
AU - Harada T
AD - 1 The Institute of Environmental Toxicology, Joso-shi, Ibaraki, Japan.
SO - Toxicol Pathol. 2018, Apr; 46(3):312-323. [Toxicologic pathology]
AB - Chromated copper arsenate (CCA) is used as a wood preservative worldwide.
Exposure to it may adversely affect human health. Some events have
increased human exposure to CCA, including the Great East Japan
Earthquake, which generated a large amount of lumber debris from
CCA-treated woods. We elucidated the toxicity due to daily exposure to CCA
over a 4-week period at doses of 0, 8, 40, and 80 mg/kg/day in Wistar
Hannover rats. Chromium (Cr) and arsenic (As), but not copper, were
detected in the plasma samples of rats treated with various doses of CCA.
Males and females showed sedation, and males had poor body weight gain.
The clinical pathologies observed in both sexes included hypochromic and
microcytic anemia, hepatic and renal dysfunction, and changes in lipid and
glucose levels. Histopathologically, males and females showed forestomach
hyperkeratosis, mucosal epithelial hyperplasia in the small intestine,
rectal goblet cell hypertrophy, and lipofuscin deposition in the proximal
renal tubule. Females showed diffuse hepatocellular hypertrophy with
increased 8-hydroxydeoxyguanosine levels. These results indicated that
oral administration of CCA mainly affected hematopoietic,
gastrointestinal, hepatic, and renal systems owing to the toxic effects of
As and/or Cr. Major toxic effects were observed in both sexes receiving 40
and 80 mg/kg/day.
KW - anemia
KW - chromated copper arsenate
KW - hyperplasia
KW - oxidative stress
KW - small intestine
LA - eng
IS - 1533-1601 (Electronic)
PT - Journal Article
TA - Toxicol Pathol
YR - 2018
DATE- 20180423
CITO- NLM
CS - United States
FJT - Toxicologic pathology
EDAT- 20180327
STAT- In-Data-Review
DOCNO- medline/29587599

191 - TOXLINE
TI - Effect of titanium dioxide nanoparticles on the accumulation and
distribution of arsenate in Daphnia magna in the presence of an algal
food.
AU - Luo Z
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen, 361021, China. zxluoire@163.com.
AU - Li M
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
AU - Wang Z
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
AU - Li J
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
AU - Guo J
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
AU - Rosenfeldt RR
AD - nEcoTox, An der Neumuehle 2, 76855, Annweiler, Germany.
AU - Seitz F
AD - nEcoTox, An der Neumuehle 2, 76855, Annweiler, Germany.
AU - Yan C
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen, 361021, China. czyan@iue.ac.cn.
SO - Environ Sci Pollut Res Int. 2018, May 15. [Environmental science and
pollution research international]
AB - The impact of titanium dioxide nanoparticles (nano-TiO2) on the
bioavailability of metals in aquatic filter-feeding organisms has rarely
been investigated, especially in the presence of algae as a food source.
In this study, we quantified the accumulation and subcellular distribution
of arsenate (AsV) in Daphnia magna in the presence of nano-TiO2 and a
green alga (Scenedesmus obliquus) food source. Results showed that S.
obliquus significantly increased the accumulation of total arsenic (As)
and titanium (Ti) in D. magna. The presence of this food source increased
As in metal-sensitive fractions (MSF) and as biologically detoxified
metals (BDM), while it decreased Ti levels in MSF but increased levels as
BDM. The difference in the subcellular distribution of As and Ti
demonstrates the dissociation of As from nano-TiO2 during digestion at
subcellular partitioning irrespective of food availability. In turn, the
presence of algae was shown to increase metal-based toxicity in D. magna
due to the transfer of As from BMD to MSF. Furthermore, S. obliquus
significantly increased the concentration of As and Ti in soluble
fractions, indicating that As and nano-TiO2 ingested by D. magna could be
transferred more readily to their predators in the presence of S.
obliquus. Our study shows the potential of algae to increase the toxicity
and biomagnification of As V . Furthermore, it highlights food as an
important factor in the toxicity assessment of nanomaterials and
co-existing pollutants.
KW - Algae
KW - Arsenic
KW - Bioavailability
KW - Nanoparticles
KW - Subcellular distribution
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180516
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180515
STAT- Publisher
DOCNO- medline/29766424

192 - TOXLINE
TI - Simultaneous influence of indigenous microorganism along with abiotic
factors controlling arsenic mobilization in Brahmaputra floodplain, India.
AU - Sathe SS
AD - Department of Civil Engineering, Indian Institute of Technology Guwahati,
Guwahati 781039, Assam, India. Electronic address: s.sathe@iitg.ernet.in.
AU - Mahanta C
AD - Department of Civil Engineering, Indian Institute of Technology Guwahati,
Guwahati 781039, Assam, India.
AU - Mishra P
AD - Department of Computer Science and Engineering, Sri Ramswaroop Memorial
College of Engineering and Management, Lucknow 227105, Uttar Pradesh, India.
SO - J Contam Hydrol. 2018, Jun; 213:1-14. [Journal of contaminant hydrology]
AB - In the dynamic cycling of oxic and anoxic aqueous alluvial aquifer
environments, varying Arsenic (As) concentrations are controlled by both
abiotic and biotic factors. Studies have shown a significant form of toxic
As (III) being released through the reductive dissolution of
iron-oxy/hydroxide minerals and microbial reduction mechanisms, which
leads to a serious health concern. The present study was performed in
order to assess the abiotic and biotic factors influencing As release into
the alluvial aquifer groundwater in Brahmaputra floodplain, India. The
groundwater chemistry, characterization of the sediments, isolation,
identification and characterization of prominent As releasing indigenous
bacterium were conducted. The measured solid and liquid phases of total As
concentration were ranged between 0.02 and 17.2&#8239;mg&#8239;kg-1 and 8
to 353&#8239;&mu;g&#8239;L-1, respectively. The morphology and mineralogy
showed the presence of detrital and authigenic mineral assemblages whereas
primary and secondary As bearing Realgar and Claudetite minerals were
identified, respectively. Furthermore, significant non-labile As fraction
was found associated with the amorphous oxides of Fe, Mn and Al. The
observed groundwater chemistry and sediment color, deduced a sub-oxic
reducing aquifer conditions in As-contaminated regions. In addition, 16S
rDNA sequencing results of the isolated bacterium showed the prominent
Pseudomonas aeruginosa responsible for the mobilization of As, reducing
condition, biomineralization and causing grey color to the sediments at
the shallower and deeper aquifers in the study area. These findings
suggest that microbial metabolic activities are equally responsible in
iron-oxy/hydroxide reductive dissolution, controlling As mobilization in
dynamic fluvial flood plains.
KW - Arsenate-reducing bacteria
KW - Arsenic
KW - Hydrogeochemistry
KW - Minerals
KW - Pseudomonas aeruginosa
KW - Sequential extraction
LA - eng
IS - 1873-6009 (Electronic)
PT - Journal Article
TA - J Contam Hydrol
YR - 2018
DATE- 20180528
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of contaminant hydrology
EDAT- 20180305
STAT- In-Data-Review
DOCNO- medline/29598853

193 - TOXLINE
TI - Arsenic-phosphorus interactions in the soil-plant-microbe system: Dynamics
of uptake, suppression and toxicity to plants.
AU - Anawar HM
AD - School of Earth and Environment (M087), The University of Western Australia,
Crawley, WA 6009, Australia. Electronic address: anawar4@hotmail.com.
AU - Rengel Z
AD - School of Earth and Environment (M087), The University of Western Australia,
Crawley, WA 6009, Australia.
AU - Damon P
AD - School of Earth and Environment (M087), The University of Western Australia,
Crawley, WA 6009, Australia.
AU - Tibbett M
AD - Centre for Agri-Environmental Research &amp; Soil Research Centre, School of
Agriculture, Policy and Development, University of Reading, RG6 6AR Reading, UK.
SO - Environ Pollut. 2018, Feb; 233:1003-1012. [Environmental pollution
(Barking, Essex : 1987)]
AB - High arsenic (As) concentrations in the soil, water and plant systems can
pose a direct health risk to humans and ecosystems. Phosphate (Pi) ions
strongly influence As availability in soil, its uptake and toxicity to
plants. Better understanding of As(V)-Pi interactions in soils and plants
will facilitate a potential remediation strategy for As contaminated
soils, reducing As uptake by crop plants and toxicity to human populations
via manipulation of soil Pi content. However, the As(V)-Pi interactions in
soil-plant systems are complex, leading to contradictory findings among
different studies. Therefore, this review investigates the role of soil
type, soil properties, minerals, Pi levels in soil and plant, Pi
transporters, mycorrhizal association and microbial activities on As-Pi
interactions in soils and hydroponics, and uptake by plants, elucidate the
key mechanisms, identify key knowledge gaps and recommend new research
directions. Although Pi suppresses As uptake by plants in hydroponic
systems, in soils it could either increase or decrease As availability and
toxicity to plants depending on the soil types, properties and charge
characteristics. In soil, As(V) availability is typically increased by the
addition of Pi. At the root surface, the Pi transport system has high
affinity for Pi over As(V). However, Pi concentration in plant influences
the As transport from roots to shoots. Mycorrhizal association may reduce
As uptake via a physiological shift to the mycorrhizal uptake pathway,
which has a greater affinity for Pi over As(V) than the root epidermal
uptake pathway.
KW - Arsenic toxicity
KW - As-Pi interactions
KW - As-Pi uptake by plants
KW - Mycorrhizal association
KW - Soil mineralogy
KW - Soil types
RN - 059QF0KO0R
RN - 27YLU75U4W
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180418
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171013
STAT- MEDLINE
DOCNO- medline/29033177

194 - TOXLINE
TI - Copper (II) and/or arsenite-induced oxidative stress cascades apoptosis
and autophagy in the skeletal muscles of chicken.
AU - Wang Y
AD - College of Wildlife Resources, Northeast Forestry University, Harbin, 150040,
Heilongjiang, PR China.
AU - Zhao H
AD - College of Wildlife Resources, Northeast Forestry University, Harbin, 150040,
Heilongjiang, PR China.
AU - Shao Y
AD - College of Wildlife Resources, Northeast Forestry University, Harbin, 150040,
Heilongjiang, PR China.
AU - Liu J
AD - College of Wildlife Resources, Northeast Forestry University, Harbin, 150040,
Heilongjiang, PR China.
AU - Li J
AD - College of Wildlife Resources, Northeast Forestry University, Harbin, 150040,
Heilongjiang, PR China.
AU - Luo L
AD - College of Wildlife Resources, Northeast Forestry University, Harbin, 150040,
Heilongjiang, PR China. Electronic address: luoly@nefu.edu.cn.
AU - Xing M
AD - College of Wildlife Resources, Northeast Forestry University, Harbin, 150040,
Heilongjiang, PR China. Electronic address: xingmingwei@nefu.edu.cn.
SO - Chemosphere. 2018, Sep; 206:597-605. [Chemosphere]
AB - Arsenic (As) is a ubiquitous environmental toxin and robust inducer of
oxidative stress (OxS). Copper (Cu) is an essential microelement, which
participates in OxS as a cofactor for certain enzymes, with narrow optimal
range between essential and toxic concentrations. However, their effects
are rarely studied in chicken skeletal muscles, which have soaring per
capita consumption andare susceptible to oxidative damage. In the present
study, we demonstrated that the administration of copper sulfate
(300&#8239;mg&#8239;kg-1) or arsenite (30&#8239;mg&#8239;kg-1)
individually or their co-administration leads to varying degrees of OxS in
the skeletal muscles of chickens. Corresponding to the protein expression
pattern, the mRNA levels of caspase, B-cell lymphoma-2 (Bcl-2) families,
and autophagy-related genes were also compromised in the experimental
groups, indicating the involvement of both apoptotic and autophagic cell
death. Additionally, rampant mitochondrial fission caused the vicious
cycle between imbalanced mitochondrial dynamics and OxS, thus tethering
intracellular homeostasis. The abovementioned muscle damage and index
anomalies were time dependent, and more deteriorated effects were observed
in Cu2+ and arsenite co-administered groups than those in groups
administered Cu2+ and arsenite alone. Intriguingly, in the studied
skeletal muscles, namely wing biceps brachii and leg gastrocnemius, there
were conspicuous differences in oxidative toxicity susceptibility, which
needs further study. The present study showed that Cu and/or As induce
oxidative damage in chicken skeletal muscles and discussed its mechanism
in terms of apoptosis, autophagy, and mitochondrial dynamics, thus voicing
concerns about poultry breeding areas cross-contaminated with Cu2+ and
arsenite.
KW - Apoptosis
KW - Arsenite
KW - Autophagy
KW - Copper (II)
KW - Oxidative stress
KW - Skeletal muscles
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180609
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20180511
STAT- In-Process
DOCNO- medline/29778937

195 - TOXLINE
TI - The dual role of mitochondrial superoxide in arsenite toxicity: Signaling
at the boundary between apoptotic commitment and cytoprotection.
AU - Fiorani M
AD - Dipartimento di Scienze Biomolecolari, Universit� degli Studi di Urbino
"Carlo Bo", 61029 Urbino, Italy. Electronic address: mara.fiorani@uniurb.it.
AU - Guidarelli A
AD - Dipartimento di Scienze Biomolecolari, Universit� degli Studi di Urbino
"Carlo Bo", 61029 Urbino, Italy. Electronic address: andrea.guidarelli@uniurb.it.
AU - Capellacci V
AD - Dipartimento di Scienze Biomolecolari, Universit� degli Studi di Urbino
"Carlo Bo", 61029 Urbino, Italy. Electronic address:
valentina.capellacci@uniurb.it.
AU - Cerioni L
AD - Dipartimento di Scienze Biomolecolari, Universit� degli Studi di Urbino
"Carlo Bo", 61029 Urbino, Italy. Electronic address: liana.cerioni@uniurb.it.
AU - Crinelli R
AD - Dipartimento di Scienze Biomolecolari, Universit� degli Studi di Urbino
"Carlo Bo", 61029 Urbino, Italy. Electronic address: rita.crinelli@uniurb.it.
AU - Cantoni O
AD - Dipartimento di Scienze Biomolecolari, Universit� degli Studi di Urbino
"Carlo Bo", 61029 Urbino, Italy. Electronic address: orazio.cantoni@uniurb.it.
SO - Toxicol Appl Pharmacol. 2018, Apr 15; 345:26-35. [Toxicology and applied
pharmacology]
AB - Arsenite toxicity is in numerous cellular systems dependent on the
formation of reactive oxygen and or nitrogen species. This is also true in
U937 cells in which the metalloid selectively promotes the formation of
mitochondrial superoxide (mitoO2-) rapidly converted to diffusible H2O2.
We tested the hypothesis that, under the same conditions, mitoO2- also
mediates the triggering of a parallel survival signaling. We found that a
low concentration of the metalloid causes an early activation of nuclear
factor erythroid 2 p45-related factor 2 (Nrf2), and a downstream signaling
leading to enhanced GSH biosynthesis, via a mechanism sensitive to various
treatments/strategies selectively preventing mitoO2- formation. Under the
same conditions, the toxic effects mediated by arsenite, leading to
delayed mitochondrial permeability transition (MPT)-dependent apoptosis,
were also prevented. Additional studies revealed remarkable similarities
in the kinetics of mitoO2- formation, MPT induction, Nrf2 activation and
GSH biosynthesis, prior to the onset of apoptosis in a small portion of
the cells. Importantly, mitoO2- formation, as well as the ensuing toxic
events, were significantly potentiated and anticipated under conditions
associated with inhibition of de novo GSH biosynthesis triggered by the
metalloid through Nrf2 activation. We conclude that, in the arsenite
toxicity paradigm under investigation, mitoO2- represents the only trigger
of two opposite pathways leading to activation of the Nrf2 signaling
and/or to a MPT-dependent apoptotic death. The first pathway, through
enhanced GSH biosynthesis, mitigates the extent of further mitoO2-
formation, thereby limiting and delaying an otherwise rapid and massive
apoptotic death.
KW - Apoptosis
KW - Arsenite
KW - Mitochondrial permeability transition
KW - Mitochondrial superoxide
KW - Nrf2, GSH
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180402
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20180308
STAT- In-Data-Review
DOCNO- medline/29526526

196 - TOXLINE
TI - Silicon Decreases Dimethylarsinic Acid Concentration in Rice Grain and
Mitigates Straighthead Disorder.
AU - Limmer MA
AD - Department of Plant &amp; Soil Sciences University of Delaware , Newark ,
Delaware 19716 , United States.
AU - Wise P
AD - Department of Plant &amp; Soil Sciences University of Delaware , Newark ,
Delaware 19716 , United States.
AU - Dykes GE
AD - Department of Plant &amp; Soil Sciences University of Delaware , Newark ,
Delaware 19716 , United States.
AU - Seyfferth AL
AD - Department of Plant &amp; Soil Sciences University of Delaware , Newark ,
Delaware 19716 , United States.
SO - Environ Sci Technol. 2018, Apr 17; 52(8):4809-4816. [Environmental science
& technology]
AB - While root Si transporters play a role in the uptake of arsenite and
organic As species dimethylarsinic acid (DMA) and monomethylarsonic acid
(MMA) in rice ( Oryza sativa L.), the impact of Si addition on the
accumulation of DMA and MMA in reproductive tissues has not been directly
evaluated, particularly in isolation from inorganic As species.
Furthermore, DMA and MMA are suspected causal agents of straighthead
disorder. We performed a hydroponic study to disentangle the impact of Si
on accumulation of DMA and MMA in rice grain. At 5 &mu;M, MMA was toxic to
rice, regardless of Si addition, although Si significantly decreased root
MMA concentrations. Plants dosed with 5 &mu;M DMA grew well vegetatively
but exhibited straighthead disorder at the lowest Si dose, and this
DMA-induced yield loss reversed with increasing solution Si. Increasing Si
also significantly decreased DMA concentrations in roots, straw, husk, and
grain, particularly in mature plants. Si restricted grain DMA through
competition for root uptake and downregulation of root Si transporters
particularly at later stages of growth when Si uptake was greatest. Our
finding that DMA causes straighthead disorder under low Si availability
but not under high Si availability suggests Si as a straighthead
management strategy.
LA - eng
IS - 1520-5851 (Electronic)
PT - Journal Article
TA - Environ Sci Technol
YR - 2018
DATE- 20180417
CITO- NLM
CS - United States
FJT - Environmental science &amp; technology
EDAT- 20180409
STAT- In-Data-Review
DOCNO- medline/29608840

197 - TOXLINE
TI - Bioaccumulation and Toxicity of Uranium, Arsenic and Nickel to Juveniles
and Adults Hyalella azteca in Spiked Sediment Bioassays.
AU - Goulet RR
AD - Department of Earth Sciences, University of Ottawa, Louis Pasteur, Ottawa,
Ontario, Canada.
AU - Thompson PA
AD - Canadian Nuclear Safety Commission, Slater, Ottawa, Ontario, Canada.
SO - Environ Toxicol Chem. 2018, May 26. [Environmental toxicology and
chemistry]
AB - Uranium mining and milling release arsenic (As), nickel (Ni) and uranium
(U) to receiving waters, which accumulate in sediments. The objective of
this study was to investigate if As, Ni and U concentrations in tissue
residue of Hyalella azteca, overlying water, sediment pore water and
solids could predict juvenile and adult survival and growth in similar
conditions to lake sediments downstream of Uranium mines and mills. We
conducted 14 day, static sediment toxicity tests spiked with uranium,
arsenic and nickel salts. For uranium, we spiked uranyl nitrate with
sodium bicarbonate to limit U precipitation once in contact with
circumneutral sediment. LC50 for As, Ni and U of juveniles and adults
based on measured concentrations in sediments were 1.8 and
2.2&thinsp;&micro;mol As/g dw, 6.3 and 13.4&thinsp;&micro;mol Ni/g dw and
0.2 and 0.9&thinsp;&micro;mol U/g dw, respectively. Adult survival and
growth linearly decreased with increasing bioaccumulation. For juveniles,
metal accumulation linearly predicted survival. We calculated lethal body
concentrations (LBC50 ) for juveniles and adults of 70 and 485 nmol As/g
dw, 246 and 832 nmol Ni/g dw and 1.7 and 4.4 nmol U/g dw, respectively.
The concentrations of As, Ni and U in tissue residue leading to a 20%
decrease in growth were 427 nmol As/g, 755 nmol Ni/g and 5 nmol U/g.
Overall, this study showed that Uranium was the most toxic element
followed by As and Ni, that juveniles were more sensitive to the three
metals tested than adults and that threshold body concentrations can
support assessment of benthic invertebrate community impairment. This
article is protected by copyright. All rights reserved.
KW - Hyalella azteca
KW - Lethal body concentration
KW - Life stage
KW - Nickel, Arsenic
KW - Uranium
LA - eng
IS - 1552-8618 (Electronic)
PT - Journal Article
TA - Environ Toxicol Chem
YR - 2018
DATE- 20180526
CI - This article is protected by copyright. All rights reserved.
CITO- NLM
CS - United States
FJT - Environmental toxicology and chemistry
EDAT- 20180526
STAT- Publisher
DOCNO- medline/29802730

198 - TOXLINE
TI - Association between serum arsenic levels and gestational diabetes
mellitus: A population-based birth cohort study.
AU - Xia X
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China.
AU - Liang C
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key
Laboratory of Population Health &amp; Aristogenics, Hefei, People's Republic of
China.
AU - Sheng J
AD - Anhui Provincial Key Laboratory of Population Health &amp; Aristogenics,
Hefei, People's Republic of China.
AU - Yan S
AD - Ma'anshan Maternal and Child Health (MCH) Center, Ma'anshan, People's
Republic of China.
AU - Huang K
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key
Laboratory of Population Health &amp; Aristogenics, Hefei, People's Republic of
China.
AU - Li Z
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China.
AU - Pan W
AD - Ma'anshan Maternal and Child Health (MCH) Center, Ma'anshan, People's
Republic of China.
AU - Tao R
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China.
AU - Hao J
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key
Laboratory of Population Health &amp; Aristogenics, Hefei, People's Republic of
China.
AU - Zhu B
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key
Laboratory of Population Health &amp; Aristogenics, Hefei, People's Republic of
China.
AU - Tong S
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China; School of Public
Health and Social Work and Institute of Health and Biomedical Innovation,
Queensland University of Technology, Brisbane, Australia; Shanghai Children's
Medical Centre, Shanghai JiaoTong University, Shanghai, People's Republic of China.
Electronic address: s.tong@qut.edu.au.
AU - Tao F
AD - Department of Maternal, Child and Adolescent Health, School of Public Health,
Anhui Medical University, Hefei, People's Republic of China; Anhui Provincial Key
Laboratory of Population Health &amp; Aristogenics, Hefei, People's Republic of
China. Electronic address: taofangbiao@126.com.
SO - Environ Pollut. 2018, Apr; 235:850-856. [Environmental pollution (Barking,
Essex : 1987)]
AB - Gestational diabetes mellitus (GDM) is a common obstetric complication
with adverse effects on both mothers and their children. Previous studies
revealed the link between Arsenic (As) exposure and incidence of diabetes
mellitus (DM), but the data on the association between maternal As
exposure and GDM is scarce. We examined this association among a
population-based birth cohort. As concentrations were determined at
multiple time points during pregnancy by ICP-MS. The association between
As levels and GDM prevalence was examined using logistic regression model
after adjustment for confounders. A total of 419 (12.85%) women were
diagnosed with GDM. The incidences of GDM gradually increased with
increasing quartiles of As levels with significant trend. As levels were
associated with the GDM (95%CI: 1.29-2.43) at only the 4th quartile in the
first trimester. After adjustment for maternal age, prepregnancy body mass
index (BMI), monthly income, gestational age and parity, the association
remains significant (95%CI: 1.22-2.38). Stratified analyses showed the
associations were largely limited to normal maternal age (95%CI:
1.19-3.04) and normal weight women (95%CI: 1.18-2.66). Our study showed an
association between As and GDM in a birth cohort and explored first
trimester may be the critical period for As associated GDM. This
association was universal in the general pregnant population of normal age
and of normal weight.
KW - Arsenic
KW - Birth cohort
KW - Gestational diabetes
KW - Prenatal exposure
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180524
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180221
STAT- MEDLINE
DOCNO- medline/29348076

199 - TOXLINE
TI - Effect on human health of the arsenic pollution and hydrogeochemistry of
the Yaz&#305;r Lake wetland (�avd&#305;r-Burdur/Turkey).
AU - Varol S
AD - Water Institute, Suleyman Demirel University, Isparta, Turkey.
simgevarol@sdu.edu.tr.
AU - K�se &#304;
AD - Department of Geology Engineering, Suleyman Demirel University, Isparta,
Turkey.
SO - Environ Sci Pollut Res Int. 2018, Jun; 25(16):16217-16235. [Environmental
science and pollution research international]
AB - In this study, the physicochemical parameters, major ions and arsenic (As)
contents of water resources in the Yaz&#305;r lake wetland, were
evaluated. In addition, water resources in this region were investigated
from the point of water quality and health risk assessment. Thirty water
samples were collected from the area in dry and wet seasons. Ca-Mg-HCO3
and Ca-HCO3 were the dominant water types. The Gibbs diagram suggests that
most of the samples fall in rock-dominance zone, which indicates the
groundwater interaction between rock chemistry. When compared to drinking
water guidelines established by World Health Organization and Turkey, much
greater attention should be paid to As, Fe, and Mn through varied
chemicals above the critical values. According to the pH-ORP diagram, the
predominant species is arsenate (H2AsO4-2). The high concentrations of As
in the surface water and groundwater are related to oxidative and
reductive dissolution reaction of Fe and Mn hydroxides within the
K&#305;z&#305;lcada&#287; ophiolite and melange. In addition, the seasonal
changes in As concentrations depend on the increase in pH of water
samples. The major toxic and carcinogenic chemical within water samples is
As for groundwater and surface water. From the results of hazard index, it
is verified that As which is taken by ingestion of water was the main
contaminant, and toxic human risk in the study area. The obtained results
will help define strategies for As problems in the water resources in
future.
KW - Arsenic
KW - Health risk assessment
KW - Hydrogeochemistry
KW - Wetland
KW - Yazır Lake
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180608
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180329
STAT- In-Process
CM - Cites: Water Res. 2011 Nov 1;45(17):5535-44 (medline /21917287)
CM - Cites: Nature. 1998 Sep 24;395(6700):338 (medline /9759723)
CM - Cites: Water Res. 2003 Jul;37(12):2929-36 (medline /12767295)
CM - Cites: J Water Health. 2016 Jun;14(3):471-88 (medline /27280612)
CM - Cites: Environ Int. 2009 Apr;35(3):466-72 (medline /18809211)
CM - Cites: Science. 1970 Dec 4;170(3962):1088-90 (medline /17777828)
CM - Cites: Environ Monit Assess. 2010 Dec;171(1-4):289-308 (medline /20072811)
CM - Cites: Food Chem Toxicol. 2010 Oct;48(10):2855-64 (medline /20643180)
CM - Cites: Sci Total Environ. 2004 Oct 15;333(1-3):267-81 (medline /15364534)
CM - Cites: Environ Pollut. 2008 Apr;152(3):686-92 (medline /17720286)
CM - Cites: Int J Hyg Environ Health. 2009 Mar;212(2):216-27 (medline
/18602865)
DOCNO- medline/29594885

200 - TOXLINE
TI - Poisoning histories in the Italian renaissance: The case of Pico Della
Mirandola and Angelo Poliziano.
AU - Gallello G
AD - Department of Archaeology, University of York, King's Manor, Exhibition
Square, YO1 7EP, York, UK. Electronic address: gianni.gallello@york.ac.uk.
AU - Cilli E
AD - Department of Cultural Heritage, Alma Mater Studiorum University of Bologna,
1 Ariani Street, 48121 Ravenna, Italy.
AU - Bartoli F
AD - Department of Biology University of Pisa, 13 Luca Ghini Street, 56126 Pisa,
Italy.
AU - Andretta M
AD - School of Engineering and Architecture, Alma Mater Studiorum University of
Bologna, CIRSA, 163 S. Alberto Street, 40123 Ravenna, Italy.
AU - Calcagnile L
AD - Department of Mathematics and Physics "Ennio De Giorgi", University of
Salento, Via per Arnesano Street, 73100 Lecce, Italy.
AU - Pastor A
AD - Department of Analytical Chemistry University of Valencia, 50 Dr. Moliner
Street, 46100 Burjassot, Valencia, Spain.
AU - de la Guardia M
AD - Department of Analytical Chemistry University of Valencia, 50 Dr. Moliner
Street, 46100 Burjassot, Valencia, Spain.
AU - Serventi P
AD - Department of Cultural Heritage, Alma Mater Studiorum University of Bologna,
1 Ariani Street, 48121 Ravenna, Italy; Department of Biological, Geological &amp;
Environmental Sciences, Alma Mater Studiorum University of Bologna, 3 Selmi Street,
Bologna, Italy.
AU - Marino A
AD - Reparto Investigazioni Scientifiche (RIS), Arma dei Carabinieri, Parma,
Italy.
AU - Benazzi S
AD - Department of Cultural Heritage, Alma Mater Studiorum University of Bologna,
1 Ariani Street, 48121 Ravenna, Italy; Department of Human Evolution, Max Planck
Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany.
AU - Gruppioni G
AD - Department of Cultural Heritage, Alma Mater Studiorum University of Bologna,
1 Ariani Street, 48121 Ravenna, Italy.
SO - J Forensic Leg Med. 2018, May; 56:83-89. [Journal of forensic and legal
medicine]
AB - Giovanni Pico della Mirandola and Angelo Poliziano were two of the most
important humanists of the Italian Renaissance. They died suddenly in 1494
and their deaths have been for centuries a subject of debate. The
exhumation of their remains offered the opportunity to study the cause of
their death through a multidisciplinary research project. Anthropological
analyses, together with documentary evidences, radiocarbon dating and
ancient DNA analysis supported the identification of the remains
attributed to Pico. Macroscopic examination did not reveal
paleopathological lesions or signs related to syphilis. Heavy metals
analysis, carried out on bones and mummified tissues, showed that in
Pico's remains there were potentially lethal levels of arsenic, supporting
the philosopher's poisoning theory reported by documentary sources. The
arsenic concentrations obtained from analysis of Poliziano's remains, are
probably more related to an As chronic exposure or diagenetic processes
rather than poisoning.
KW - Ancient DNA
KW - Angelo Poliziano
KW - Arsenic poisoning
KW - Girolamo benivieni
KW - Pico della Mirandola
KW - Radiocarbon dating
RN - N712M78A8G
LA - eng
IS - 1878-7487 (Electronic)
PT - Historical Article
PT - Journal Article
TA - J Forensic Leg Med
YR - 2018
DATE- 20180524
CI - Copyright &copy; 2018 Elsevier Ltd and Faculty of Forensic and Legal
Medicine. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Journal of forensic and legal medicine
EDAT- 20180328
STAT- MEDLINE
DOCNO- medline/29609050

201 - TOXLINE
TI - Arsenic uptake and accumulation in rice (Oryza sativa L.) with selenite
fertilization and water management.
AU - Wan Y
AD - Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation,
Key Laboratory of Plant-Soil Interactions of the Ministry of Education, China
Agricultural University, Beijing 100193, People's Republic of China.
AU - Camara AY
AD - Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation,
Key Laboratory of Plant-Soil Interactions of the Ministry of Education, China
Agricultural University, Beijing 100193, People's Republic of China; Department of
Water/Forest and Environment, Higher Institute of Agronomy and Veterinary of
Faranah, B.P. 131, Republic of Guinea.
AU - Huang Q
AD - Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation,
Key Laboratory of Plant-Soil Interactions of the Ministry of Education, China
Agricultural University, Beijing 100193, People's Republic of China; Gro-
Environmental Protection Institute, Ministry of Agriculture, Tianjin 300191,
People's Republic of China.
AU - Yu Y
AD - Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation,
Key Laboratory of Plant-Soil Interactions of the Ministry of Education, China
Agricultural University, Beijing 100193, People's Republic of China.
AU - Wang Q
AD - Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation,
Key Laboratory of Plant-Soil Interactions of the Ministry of Education, China
Agricultural University, Beijing 100193, People's Republic of China.
AU - Li H
AD - Beijing Key Laboratory of Farmland Soil Pollution Prevention and Remediation,
Key Laboratory of Plant-Soil Interactions of the Ministry of Education, China
Agricultural University, Beijing 100193, People's Republic of China. Electronic
address: lihuafen@cau.edu.cn.
SO - Ecotoxicol Environ Saf. 2018, Jul 30; 156:67-74. [Ecotoxicology and
environmental safety]
AB - The accumulation of arsenic (As) in rice grain is a potential threat to
human health. Our study investigated the possible mediatory role of
selenite fertilization on As uptake and accumulation by rice (Oryza sativa
L.) under different water management regimes (aerobic or flooded) in a pot
experiment. Soil solutions were also extracted during the growing season
to monitor As dynamics. Results showed that As contents in the soil
solutions, seedlings, and mature rice were higher under flooded than under
aerobic water management. Under aerobic conditions, selenite additions
slightly increased As concentrations in soil solutions (in the last two
samplings), but decreased As levels in rice plants. Relative to the
control, 0.5&#8239;mg&#8239;kg-1 selenite decreased rice grain As by
27.5%. Under flooded conditions, however, selenite additions decreased As
in soil solutions, while increased As in rice grain. Tendencies also
showed that selenite additions decreased the proportion of As in rice
shoots both at the seedling stage and maturity, and were more effective in
aerobic soil. Our results demonstrate that the effect of selenite
fertilizer on As accumulation by rice is related to water management.
KW - Arsenic
KW - Arsenic uptake and accumulation
KW - Rice (Oryza sativa L.)
KW - Selenite
KW - Water management
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180407
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180309
STAT- In-Process
DOCNO- medline/29529515

202 - TOXLINE
TI - Effect of microbially mediated iron mineral transformation on temporal
variation of arsenic in the Pleistocene aquifers of the central Yangtze
River basin.
AU - Deng Y
AD - Geological Survey, China University of Geosciences, Wuhan, China; State Key
Laboratory of Biogeology and Environmental Geology, China University of
Geosciences, Wuhan, China. Electronic address: yamin.deng@cug.edu.cn.
AU - Zheng T
AD - Geological Survey, China University of Geosciences, Wuhan, China.
AU - Wang Y
AD - State Key Laboratory of Biogeology and Environmental Geology, China
University of Geosciences, Wuhan, China; School of Environmental Studies, China
University of Geosciences, Wuhan, China. Electronic address: yx.wang@cug.edu.cn.
AU - Liu L
AD - Geological Survey, China University of Geosciences, Wuhan, China.
AU - Jiang H
AD - State Key Laboratory of Biogeology and Environmental Geology, China
University of Geosciences, Wuhan, China.
AU - Ma T
AD - State Key Laboratory of Biogeology and Environmental Geology, China
University of Geosciences, Wuhan, China; School of Environmental Studies, China
University of Geosciences, Wuhan, China.
SO - Sci Total Environ. 2018, Apr 01; 619-620:1247-1258. [The Science of the
total environment]
AB - Significant seasonal variation of groundwater arsenic (As) concentrations
in shallow aquifers of the Jianghan Plain, central Yangtze River Basin has
been reported recently, but the underlying mechanisms remain not well
understood. To elaborate biogeochemical processes responsible for the
observed As concentration variation, 42-day incubation experiments were
done using sediment samples collected respectively from the depth of 26,
36 and 60m of the As-affected aquifer which were labeled respectively as
JH26, JH36, JH60. Where JH denotes Jianghan Plain, and the number
indicates the depth of the sediment sample. The results indicated that As
could be mobilized from the sediments of 26m and 36m depth under the
stimulation of exogenous organic carbon, with the maximum As release
amount of 1.60 and 1.03mgkg-1, respectively, while the sediments at 60m
depth did not show As mobilization. The microbially mediated reductive
dissolution of amorphous iron oxides and reduction of As(V) to As(III)
could account for the observed As mobilization. The 16S rRNA
high-throughput sequencing results indicated that the variation of
microbial community correlated with the released As concentration (R=0.7,
P < 0.05) and the iron-reducing bacteria, including Pseudomonas,
Clostridium and Geobacter, were the main drivers for the As mobilization
from the sediments at 26m and 36m depth. The increase of arsC gene
abundance (up to 1.4&times;105 copies g-1) during As release suggested
that As reduction was mediated by the resistant reduction mechanism. By
contrast, in the 60m sediments where the Fe and As release was absent, the
iron-reducing bacteria accounted for a very minor proportion and
sulfate-reducing bacteria were predominant in the microbial community. In
addition, after 30days of incubation, the released As in the 26m sediments
was immobilized via co-precipitation with or adsorption onto the
Fe-sulfide mineral newly-formed by the bacterial sulfate reduction. These
results are consistent with the results of our previous field monitoring,
indicating that the bacterial sulfate reduction could lead to the temporal
decrease in groundwater As concentrations. This study provides insights
into the mechanism for As mobilization and seasonal As concentration
variation in the Pleistocene aquifers from alluvial plains.
KW - Arsenic mobilization
KW - Groundwater
KW - Iron mineral transformation
KW - Jianghan plain
KW - Sulfate reduction
KW - Temporal variation
RN - E1UOL152H7
RN - N712M78A8G
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180607
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20171129
STAT- MEDLINE
DOCNO- medline/29734603

203 - TOXLINE
TI - Effects of lead, cadmium, arsenic, and mercury co-exposure on children's
intelligence quotient in an industrialized area of southern China.
AU - Pan S
AD - State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of
Environmental Protection and Resources Utilization, Guangzhou Institute of
Geochemistry, and Guangzhou Key Laboratory of Environmental Pollution and Health
Risk Assessment, Chinese Academy of Sciences, Guangzhou 510640, China; Guangdong
Provincial Center for Disease Control and Prevention, Guangzhou 511430, China;
University of Chinese Academy of Sciences, Beijing 100049, China.
AU - Lin L
AD - Guangdong Provincial Center for Disease Control and Prevention, Guangzhou
511430, China.
AU - Zeng F
AD - Center for Disease Control and Prevention of Qujiang District, Shaoguan
512100, China.
AU - Zhang J
AD - Guangdong Provincial Center for Disease Control and Prevention, Guangzhou
511430, China.
AU - Dong G
AD - Department of Preventive Medicine, School of Public Health, Sun Yat-sen
University, Guangzhou 510080, China.
AU - Yang B
AD - Department of Preventive Medicine, School of Public Health, Sun Yat-sen
University, Guangzhou 510080, China.
AU - Jing Y
AD - School of Environment, Guangzhou Key Laboratory of Environmental Exposure and
Health, and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan
University, Guangzhou 510632, China.
AU - Chen S
AD - State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of
Environmental Protection and Resources Utilization, Guangzhou Institute of
Geochemistry, and Guangzhou Key Laboratory of Environmental Pollution and Health
Risk Assessment, Chinese Academy of Sciences, Guangzhou 510640, China.
AU - Zhang G
AD - State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of
Environmental Protection and Resources Utilization, Guangzhou Institute of
Geochemistry, and Guangzhou Key Laboratory of Environmental Pollution and Health
Risk Assessment, Chinese Academy of Sciences, Guangzhou 510640, China.
AU - Yu Z
AD - State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of
Environmental Protection and Resources Utilization, Guangzhou Institute of
Geochemistry, and Guangzhou Key Laboratory of Environmental Pollution and Health
Risk Assessment, Chinese Academy of Sciences, Guangzhou 510640, China.
AU - Sheng G
AD - State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of
Environmental Protection and Resources Utilization, Guangzhou Institute of
Geochemistry, and Guangzhou Key Laboratory of Environmental Pollution and Health
Risk Assessment, Chinese Academy of Sciences, Guangzhou 510640, China.
AU - Ma H
AD - State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of
Environmental Protection and Resources Utilization, Guangzhou Institute of
Geochemistry, and Guangzhou Key Laboratory of Environmental Pollution and Health
Risk Assessment, Chinese Academy of Sciences, Guangzhou 510640, China. Electronic
address: mahuimin@gig.ac.cn.
SO - Environ Pollut. 2018, Apr; 235:47-54. [Environmental pollution (Barking,
Essex : 1987)]
AB - Exposure to metal(loid)s can lead to adverse effects on nervous system in
children. However, little is known about the possible interaction effects
of simultaneous exposure to multiple metal(loid)s on children's
intelligence. In addition, relationship between blood lead concentrations
( < 100&#8239;&mu;g/L) and the intelligence of children over 5 years
needs further epidemiological evidence. We recruited 530 children aged
9-11 years, including 266 living in a town near an industrialized area and
264 from another town in the same city in South China as a reference. The
levels of lead (Pb), cadmium (Cd), arsenic (As) and mercury (Hg) in blood
(BPb, BCd, BAs, BHg) and urine (UPb, UCd, UAs, UHg) were assessed, as well
as children's intelligence quotient (IQ). A significant decrease in IQ
scores was identified in children from the industrialized town
(p&#8239; < &#8239;.05), who had statistically higher geometric mean
concentrations of BPb, BCd, UPb, UCd and UHg (65.89, 1.93, 4.04, 1.43 and
0.37&#8239;&mu;g/L, respectively) compared with children from the
reference town (37.21, 1.07, 2.14, 1.02 and 0.30&#8239;&mu;g/L,
respectively, p&#8239; < &#8239;.05). After adjusting confounders, only
BPb had a significant negative association with IQ (B&#8239;=&#8239;-0.10,
95% confidence interval: -0.15 to -0.05,
p&#8239; < &#8239;.001), which indicated that IQ decreased 0.10 points
when BPb increased 1&#8239;&mu;g/L. Significant negative interactions
between BAs and BHg, positive interaction between UPb and UCd on IQ were
observed (p&#8239; < &#8239;.10), and BPb < 100&#8239;&mu;g/L still
negatively affected IQ (p&#8239; < &#8239;.05). Our findings suggest that
although only BPb causes a decline in children's IQ when simultaneously
exposed to these four metal(loid)s at relatively low levels, interactions
between metal(loid)s on children's IQ should be paid special attention,
and the reference standard in China of 100&#8239;&mu;g/L BPb for children
above 5 years old should be revised.
KW - Arsenic
KW - Cadmium
KW - Intelligence quotient scores
KW - Lead
KW - Mercury
RN - 00BH33GNGH
RN - 2P299V784P
RN - FXS1BY2PGL
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180523
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171220
STAT- MEDLINE
DOCNO- medline/29274537

204 - TOXLINE
TI - Investigation on stability and leaching characteristics of mixtures of
biogenic arsenosulphides and iron sulphides formed under reduced
conditions.
AU - Shakya AK
AD - Department of Civil Engineering, Indian Institute of technology Guwahati,
781039, India.
AU - Rajput P
AD - Atomic &amp; Molecular Physics Division, Bhabha Atomic Research Centre,
Trombay, Mumbai, 400085, India.
AU - Ghosh PK
AD - Department of Civil Engineering, Indian Institute of technology Guwahati,
781039, India. Electronic address: pkghosh@iitg.ernet.in.
SO - J Hazard Mater. 2018, Jul 05; 353:320-328. [Journal of hazardous
materials]
AB - Arsenic is removed from aqueous phase through precipitation as
arsenosulphides and/or co-precipitation and adsorption on iron sulphides.
Studies were carried out to ascertain the stability of reduced biogenic
arsenic and iron sulphide precipitates formed in an attached growth
reactor (AGR) through a series of experiments based on Toxicity
Characteristic Leaching Procedure (TCLP), aging and long term leaching
tests. About half of the AGR was initially added with waste activated
carbon (WAC) to support the growth of mixed microbial consortia and used
for treatment of arsenic and iron contaminated simulated groundwater. The
X-ray diffraction (XRD), X-ray absorption near-edge structure (XANES) and
extended X-ray absorption fine structure (EXAFS) spectroscopy results
indicated that the biosolids were mainly composed of arsenosulphides and
iron sulphides. While TCLP and aging tests were conducted in anoxic as
well as oxic conditions with the aim to evaluate stability of biomass
containing biogenic sulphides, long term leaching test was conducted
through supply of aerated distilled water to evaluate the stability of
spent WAC as well. Results generated from the research indicate that the
concentration of leached arsenic never exceeded 123&#8239;&mu;g/L under
all conditions tested, thus biosolids not imposing an environmental
hazard.
KW - Arsenic
KW - Biogenic sulphides
KW - Iron
KW - Stability
KW - TCLP
LA - eng
IS - 1873-3336 (Electronic)
PT - Journal Article
TA - J Hazard Mater
YR - 2018
DATE- 20180615
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of hazardous materials
EDAT- 20180416
STAT- In-Data-Review
DOCNO- medline/29680690

205 - TOXLINE
TI - Opportunities and challenges in the use of mineral nutrition for
minimizing arsenic toxicity and accumulation in rice: A critical review.
AU - Saifullah
AD - Department of Environmental Health, College of Public Health, Imam
Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Institute for Research and
Medical Consultation (IRMC), Imam Abdulrehman Bin Faisal University, P.O. Box 1982,
Dammam, 31441, Saudi Arabia. Electronic address: smferoz@uod.edu.sa.
AU - Dahlawi S
AD - Department of Environmental Health, College of Public Health, Imam
Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; Institute for Research and
Medical Consultation (IRMC), Imam Abdulrehman Bin Faisal University, P.O. Box 1982,
Dammam, 31441, Saudi Arabia.
AU - Naeem A
AD - Institute of Soil and Environmental Sciences, University of Agriculture,
Faisalabad, Pakistan; Nuclear Institute of Agriculture and Biology, Jhang Road,
Faisalabad, Pakistan.
AU - Iqbal M
AD - Department of Botany, Jamia Hamdard (Hamdard University), New Delhi, India.
AU - Farooq MA
AD - Institute of Soil and Environmental Sciences, University of Agriculture,
Faisalabad, Pakistan.
AU - Bibi S
AD - Institute of Soil and Environmental Sciences, University of Agriculture,
Faisalabad, Pakistan.
AU - Rengel Z
AD - School of Agriculture and Environment, University of Western Australia, 35
Stirling Highway, Perth, WA, 6009, Australia.
SO - Chemosphere. 2018, Mar; 194:171-188. [Chemosphere]
AB - Growing rice on arsenic (As)-contaminated soil or irrigating with
As-contaminated water leads to significant accumulation of As in grains.
Moreover, rice accumulates more As into grains than other cereal crops.
Thus, rice consumption has been identified as a major route of human
exposure to As in many countries. Inorganic As species are carcinogenic
and could pose a considerable health risk to humans even at low dietary
concentration. Genotypic variation and concentration of nutrients such as
iron, manganese, phosphate, sulfur and silicon are the two main factors
that affect As accumulation in rice grains. Therefore, in addition to
better growth and yield of plants, application of specific nutrients in
optimum quantities offers an added benefit of decreasing As content in
rice grains. These nutrient elements influence speciation of As in
rhizosphere, compete with As for root uptake and interfere with As
translocations to the shoot and ultimately accumulation in grains. This
papers critically appraises the methods, forms and rate of application,
mechanisms and extent of efficiency of different mineral nutrients in
decreasing As accumulation in rice grains.
KW - Arsenic
KW - Grain accumulation
KW - Immobilization
KW - Plant nutrition
KW - Uptake
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
PT - Review
TA - Chemosphere
YR - 2018
DATE- 20180402
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171205
STAT- MEDLINE
DOCNO- medline/29202269

206 - TOXLINE
TI - Arsenic-containing hydrocarbons: effects on gene expression, epigenetics,
and biotransformation in HepG2 cells.
AU - M�ller SM
AD - Heinrich-Stockmeyer Foundation, Parkstra&szlig;e 44-46, 49214, Bad
Rothenfelde, Germany.
AU - Finke H
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany.
AU - Ebert F
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany.
AU - Kopp JF
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany.
AU - Schumacher F
AD - Department of Molecular Biology, University of Duisburg-Essen, Hufelandstr.
55, 45122, Essen, Germany.
AU - Kleuser B
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany.
AU - Francesconi KA
AD - Institute of Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1,
8010, Graz, Austria.
AU - Raber G
AD - Institute of Chemistry, NAWI Graz, University of Graz, Universitaetsplatz 1,
8010, Graz, Austria.
AU - Schwerdtle T
AD - Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-
Allee 114-116, 14558, Nuthetal, Germany. tanja.schwerdtle@uni-potsdam.de.
SO - Arch Toxicol. 2018, May; 92(5):1751-1765. [Archives of toxicology]
AB - Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found
in fish and algae, elicit substantial toxic effects in various human cell
lines and have a considerable impact on cellular energy levels. The
underlying mode of action, however, is still unknown. The present study
analyzes the effects of two AsHCs (AsHC 332 and AsHC 360) on the
expression of 44 genes covering DNA repair, stress response, cell death,
autophagy, and epigenetics via RT-qPCR in human liver (HepG2) cells. Both
AsHCs affected the gene expression, but to different extents. After
treatment with AsHC 360, flap structure-specific endonuclease 1 (FEN1) as
well as xeroderma pigmentosum group A complementing protein (XPA) and
(cytosine-5)-methyltransferase 3A (DNMT3A) showed time- and
concentration-dependent alterations in gene expression, thereby indicating
an impact on genomic stability. In the subsequent analysis of epigenetic
markers, within 72 h, neither AsHC 332 nor AsHC 360 showed an impact
on the global DNA methylation level, whereas incubation with AsHC 360
increased the global DNA hydroxymethylation level. Analysis of cell
extracts and cell media by HPLC-mass spectrometry revealed that both AsHCs
were considerably biotransformed. The identified metabolites include not
only the respective thioxo-analogs of the two AsHCs, but also several
arsenic-containing fatty acids and fatty alcohols, contributing to our
knowledge of biotransformation mechanisms of arsenolipids.
KW - Arsenic speciation
KW - Arsenic-containing hydrocarbons
KW - Arsenolipids
KW - Gene expression
KW - Global DNA methylation
KW - Metabolism
LA - eng
IS - 1432-0738 (Electronic)
PT - Journal Article
TA - Arch Toxicol
YR - 2018
DATE- 20180522
CITO- NLM
CS - Germany
FJT - Archives of toxicology
EDAT- 20180330
STAT- In-Data-Review
DOCNO- medline/29602950

207 - TOXLINE
TI - Effects of kinetin on plant growth and chloroplast ultrastructure of two
Pteris species under arsenate stress.
AU - Li Q
AD - Faculty of Environmental Science and Engineering, Kunming University of
Science and Technology, Kunming 650500, Yunnan, China.
AU - Wang H
AD - Faculty of Environmental Science and Engineering, Kunming University of
Science and Technology, Kunming 650500, Yunnan, China. Electronic address:
whb1974@126.com.
AU - Wang H
AD - Faculty of Environmental Science and Engineering, Kunming University of
Science and Technology, Kunming 650500, Yunnan, China.
AU - Zheng W
AD - Faculty of Environmental Science and Engineering, Kunming University of
Science and Technology, Kunming 650500, Yunnan, China.
AU - Wu D
AD - Faculty of Environmental Science and Engineering, Kunming University of
Science and Technology, Kunming 650500, Yunnan, China.
AU - Wang Z
AD - Faculty of Environmental Science and Engineering, Kunming University of
Science and Technology, Kunming 650500, Yunnan, China.
SO - Ecotoxicol Environ Saf. 2018, Aug 30; 158:37-43. [Ecotoxicology and
environmental safety]
AB - Cytokinins (CTKs) are effective in alleviating abiotic stresses on plants,
but little information is available regarding the effects of CTKs on
arsenic (As) accumulation and changes of chloroplast ultrastructure in
plants with different As-accumulating ability. Here a hydroponic
experiment was designed to evaluate the effects of different concentration
of kinetin (KT, 0-40&#8239;mg/L) on growth and chloroplast ultrastructure
of As hyperaccumulator Pteris cretica var. nervosa and
non-hyperaccumulator Pteris ensiformis treated by 5&#8239;mg/L arsenate
for 14 days. The growth parameters, As accumulation, contents of
photosynthetic pigments and chloroplast ultrastructure were examined. The
results showed that KT promoted the growth of two plants, and
significantly increased As accumulation and translocation in P. cretica
var. nervosa and P. ensiformis at 5 and 20&#8239;mg/L, respectively.
Additionally, the contents of chlorophyll a and carotenoid in two plants
showed no significant difference at 20&#8239;mg/L KT compared to the
control. Chloroplast ultrastructure of P. cretica var. nervosa was
integral with KT application. Comparatively, the swollen chloroplasts were
increased, plasmolysis appeared, and chloroplast grana slice layers and
stroma lamellas were clearly separated or distorted at 5&#8239;mg/L KT in
P. ensiformis. The length and width of chloroplasts in P. cretica var.
nervosa were significantly increased with KT addition compared to the
control. However, the length of chloroplasts in P. ensiformis was
significantly decreased but their width showed no significant change.
Furthermore, the deterioration of chloroplast ultrastructure in P.
ensiformis was ameliorated by 40&#8239;mg/L KT. These results suggested
that KT increased As accumulation and was beneficial to maintain the
photosynthetic pigments for a good growth of plants. Therefore, KT could
maintain and reorganize the ultrastructure integrality of As-stressed
chloroplasts to some extent for the two plants, especially at high
concentration.
KW - Arsenic
KW - Chloroplast
KW - Cytokinins
KW - Kinetin
KW - Ultrastructure
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180522
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180412
STAT- In-Process
DOCNO- medline/29656162

208 - TOXLINE
TI - Purifying arsenic and fluoride-contaminated water by a novel
graphene-based nanocomposite membrane of enhanced selectivity and
sustained flux.
AU - Pal M
AD - Environment and Membrane Technology Laboratory, Department of Chemical
Engineering, National Institute of Technology, Durgapur, 713209, India.
AU - Mondal MK
AD - Environment and Membrane Technology Laboratory, Department of Chemical
Engineering, National Institute of Technology, Durgapur, 713209, India.
AU - Paine TK
AD - Department of Inorganic Chemistry, Indian Association for the Cultivation of
Science, Jadavpur, Kolkata, 700032, India.
AU - Pal P
AD - Environment and Membrane Technology Laboratory, Department of Chemical
Engineering, National Institute of Technology, Durgapur, 713209, India.
parimalpal2000@yahoo.com.
SO - Environ Sci Pollut Res Int. 2018, Mar 29. [Environmental science and
pollution research international]
AB - A novel graphene-based nanocomposite membrane was synthesized by
interfacial polymerization (IP) through chemical bonding of the graphene
oxide (GO) layer to polyethersulfone surface. Detailed characterization of
the composite membrane through AFM, SEM, ATR-FTIR, XRD analysis, and Raman
spectroscopy indicates strong potential of the membrane in highly
selective removal of the toxic contaminants like arsenic and fluoride
while permeating the essential minerals like calcium and magnesium. This
makes the membrane suitable for production of safe drinking water from
contaminated water. The membrane applied in a flat-sheet cross-flow module
succeeded in removal of more than 98% arsenic and around 80% fluoride from
contaminated water while selectively retaining the useful calcium and
magnesium minerals in drinking water. A sustained pure water flux of
around 150 LMH (liter per square meter per hour) during operation over
long hours ( > &thinsp;150 h) with only 3-5% drop in flux indicates
antifouling character of the membrane module.
KW - Arsenic removal
KW - Enhanced selectivity
KW - Novel nanocomposite membrane
KW - Sustained flux
KW - Water contaminant
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180329
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180329
STAT- Publisher
DOCNO- medline/29594887

209 - TOXLINE
TI - Prenatal arsenic exposure and dietary folate and methylcobalamin
supplementation alter the metabolic phenotype of C57BL/6J mice in a
sex-specific manner.
AU - Huang MC
AD - Curriculum in Toxicology, School of Medicine, University of North Carolina at
Chapel Hill, Chapel Hill, NC, USA.
AU - Douillet C
AD - Department of Nutrition, Gillings School of Global Public Health, University
of North Carolina at Chapel Hill, CB# 7461, Chapel Hill, NC, USA.
AU - Dover EN
AD - Curriculum in Toxicology, School of Medicine, University of North Carolina at
Chapel Hill, Chapel Hill, NC, USA.
AU - St�blo M
AD - Department of Nutrition, Gillings School of Global Public Health, University
of North Carolina at Chapel Hill, CB# 7461, Chapel Hill, NC, USA.
styblo@med.unc.edu.
SO - Arch Toxicol. 2018, Jun; 92(6):1925-1937. [Archives of toxicology]
AB - Inorganic arsenic (iAs) is an established environmental diabetogen. The
link between iAs exposure and diabetes is supported by evidence from adult
human cohorts and adult laboratory animals. The contribution of prenatal
iAs exposure to the development of diabetes and underlying mechanisms are
understudied. The role of factors that modulate iAs metabolism and
toxicity in adults and their potential to influence diabetogenic effects
of prenatal iAs exposure are also unclear. The goal of this study was to
determine if prenatal exposure to iAs impairs glucose metabolism in mice
and if maternal supplementation with folate and methylcobalamin (B12) can
modify this outcome. C57BL/6J dams were exposed to iAs in drinking water
(0, 100, and 1000 &micro;g As/L) and fed a folate/B12 adequate or
supplemented diet from before mating to birth of offspring. After birth,
dams and offspring drank deionized water and were fed the folate/B12
adequate diet. The metabolic phenotype of offspring was assessed over the
course of 14 weeks. Male offspring from iAs-exposed dams fed the
folate/B12-adequate diet developed fasting hyperglycemia and insulin
resistance. Maternal folate/B12 supplementation rescued this phenotype but
had only marginal effects on iAs metabolism in dams. The diabetogenic
effects of prenatal iAs exposure in male offspring were not associated
with changes in global DNA methylation in the liver. Only minimal effects
of prenatal iAs exposure or maternal supplementation were observed in
female offspring. These results suggest that prenatal iAs exposure impairs
glucose metabolism in a sex-specific manner and that maternal folate/B12
supplementation may improve the metabolic phenotype in offspring. Further
studies are needed to identify the mechanisms underlying these effects.
KW - Arsenic
KW - Diabetes
KW - Dietary supplementation
KW - Folate
KW - Methylcobalamin
KW - Prenatal exposure
KW - Vitamin
LA - eng
IS - 1432-0738 (Electronic)
PT - Journal Article
TA - Arch Toxicol
YR - 2018
DATE- 20180615
CITO- NLM
CS - Germany
FJT - Archives of toxicology
EDAT- 20180502
STAT- In-Data-Review
DOCNO- medline/29721587

210 - TOXLINE
TI - Rates and processes affecting As speciation and mobility in lake sediments
during aging.
AU - Lock A
AD - Environmental and Life Sciences Graduate Program, Trent University,
Peterborough, Ontario, Canada. Electronic address: alock@laurentian.ca.
AU - Wallschl�ger D
AD - School of the Environment, Department of Chemistry and Water Quality Centre,
Trent University, Peterborough, Ontario, Canada.
AU - Belzile N
AD - Department of Chemistry, Laurentian University, Sudbury, Ontario, Canada.
AU - Spiers G
AD - School of the Environment, Departments of Earth Sciences and Biology,
Laurentian University, Sudbury, Ontario, Canada.
AU - Gueguen C
AD - School of the Environment and Chemistry Department, Trent University,
Peterborough, Ontario, Canada.
SO - J Environ Sci (China). 2018, Apr; 66:338-347. [Journal of environmental
sciences (China)]
AB - Sediments from an arsenic (As) contaminated groundwater vent site were
used to investigate As(III) binding, transformation and redistribution in
native and iron oxide amended lake sediments using aging spiked batch
reactions and a sequential extraction procedure that maintains As(V) and
As(III) speciation. In the native sediments, fractionation analysis
revealed that 10% of the spiked As(III) remained intact after a 32-day
aging experiment and was predominantly adsorbed to the strongly sorbed
(NH4H2PO4 extractable) and amorphous Fe oxide bound (H3PO4 extractable)
fractions. Kinetic modelling of the experimental results allowed
identifying the dominant reaction path for depletion of dissolved As(III)
to As(III) absorbed on to the solid phase, followed by oxidation in the
solid phase. Arsenite was initially adsorbed primarily to the easily
exchangeable fraction ((NH4)2SO4 extractable), then rapidly transformed
into As(V) and redistributed to the strongly sorbed and amorphous Fe oxide
bound fractions. Oxidation of As(III) in recalcitrant fractions was less
efficient. The iron oxide amendments illustrated the controls that iron
oxides can have on As(III) binding and transformation rates. In goethite
amended samples As(III) oxidation was faster and primarily occurred in the
strongly sorbed and amorphous Fe oxide bound fractions. In these samples,
19.3&mu;g Mn was redistributed (compared to the native sediment) from the
easily exchangeable and crystalline Fe oxide bound fractions to the
strongly sorbed and amorphous Fe oxide bound fractions, indicating that
goethite may act as a catalyst for Mn(II) oxidation, thereby producing
sorbed Mn(III/IV), which then appears to be involved in rapidly oxidizing
As(III).
KW - Arsenite
KW - Fractionation
KW - Modelling
KW - Oxidation
KW - Redistribution
RN - N712M78A8G
LA - eng
IS - 1001-0742 (Print)
PT - Journal Article
TA - J Environ Sci (China)
YR - 2018
DATE- 20180419
CI - Copyright &copy; 2017. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Journal of environmental sciences (China)
EDAT- 20170510
STAT- MEDLINE
DOCNO- medline/29628103

211 - TOXLINE
TI - Genetic characterization, micropropagation, and potential use for arsenic
phytoremediation of Dittrichia viscosa (L.) Greuter.
AU - Guarino F
AD - Department of Chemistry and Biology "A. Zambelli" University of Salerno, Via
Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy. Electronic address:
fguarino@unisa.it.
AU - Conte B
AD - Department of Science and Technology, University of Sannio, Via Port'Arsa,
11, 82100 Benevento, Italy. Electronic address: bbconte@yahoo.it.
AU - Improta G
AD - Department of Public Health, University of Napoli Federico II, Via Pansini 5,
80131 Napoli, Italy. Electronic address: ing.improta@gmail.com.
AU - Sciarrillo R
AD - Department of Science and Technology, University of Sannio, Via Port'Arsa,
11, 82100 Benevento, Italy. Electronic address: sciarrillo@unisannio.it.
AU - Castiglione S
AD - Department of Chemistry and Biology "A. Zambelli" University of Salerno, Via
Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy. Electronic address:
scastiglione@unisa.it.
AU - Cicatelli A
AD - Department of Chemistry and Biology "A. Zambelli" University of Salerno, Via
Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy. Electronic address:
acicatelli@unisa.it.
AU - Guarino C
AD - Department of Science and Technology, University of Sannio, Via Port'Arsa,
11, 82100 Benevento, Italy. Electronic address: guarino@unisannio.it.
SO - Ecotoxicol Environ Saf. 2018, Feb; 148:675-683. [Ecotoxicology and
environmental safety]
AB - In the last decade, many scientists have focused their attention on the
search for new plant species that can offer improved capacities to reclaim
polluted soils and waters via phytoremediation. In this study, seed
batches from three natural populations of Dittrichia viscosa, harvested in
rural, urban, and industrial areas of central and southern Italy, were
used to: (i) evaluate the genetic and morphological diversity of the
populations; (ii) develop an efficient protocol for in-vitro propagation
from seedling microcuttings; (iii) achieve optimal acclimatization of
micropropagated plants to greenhouse conditions; (iv) test the response to
arsenic (As) soil contamination of micropropagated plants. The genetic
biodiversity study, based on Random Amplification of Polymorphic DNA
(RAPD), as well as the morphometric analysis of 20 seedlings from each
population revealed some degree of differentiation among populations.
Based on these data, the most biodiverse plants from the three populations
(10 lines each) were clonally multiplied by micropropagation using
microcuttings of in-vitro grown seedlings. Three culture media were tested
and Mureshige and Skoog medium was chosen for both seedling growth and
micropropagation. The micropropagated plants responded well to greenhouse
conditions and over 95% survived the acclimatization phase. Four clones
were tested for their capacity to grow on soil spiked with NaAsO2 and to
absorb and accumulate the metalloid. All clones tolerated up to 1.0mg As.
At the end of the trial (five weeks), As was detectable only in leaves of
As-treated plants and concentration varied significantly among clones. The
amount of As present in plants (leaves) corresponded to ca. 0.10-1.7% of
the amount supplied. However, As was no longer detectable in soil
suggesting that the metalloid was taken up, translocated and probably
phytovolatilized.
KW - Arsenic pollution
KW - Dittrichia viscosa
KW - Genetic study
KW - In vitro culture
KW - Phytotechnology
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180518
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171121
STAT- MEDLINE
DOCNO- medline/29172148

212 - TOXLINE
TI - Comparison of DGT with traditional extraction methods for assessing
arsenic bioavailability to Brassica chinensis in different soils.
AU - Dai Y
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Yangling, 712100, China; Key Laboratory of Plant Nutrition and Agri-environment in
Northwest China, Ministry of Agriculture, China.
AU - Nasir M
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Yangling, 712100, China; Key Laboratory of Plant Nutrition and Agri-environment in
Northwest China, Ministry of Agriculture, China.
AU - Zhang Y
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Yangling, 712100, China.
AU - Gao J
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Yangling, 712100, China; Key Laboratory of Plant Nutrition and Agri-environment in
Northwest China, Ministry of Agriculture, China.
AU - Lv Y
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Yangling, 712100, China; Key Laboratory of Plant Nutrition and Agri-environment in
Northwest China, Ministry of Agriculture, China.
AU - Lv J
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Yangling, 712100, China; Key Laboratory of Plant Nutrition and Agri-environment in
Northwest China, Ministry of Agriculture, China. Electronic address:
ljlll@nwsuaf.edu.cn.
SO - Chemosphere. 2018, Jan; 191(10):183-189. [Chemosphere]
AB - Several predictive models and methods have been used for heavy metals
bioavailability, but there is no universally accepted approach in
evaluating the bioavailability of arsenic (As) in soil. The technique of
diffusive gradients in thin-films (DGT) is a promising tool, but there is
a considerable debate with respect to its suitability. The DGT method was
compared with other traditional chemical extractions techniques (soil
solution, NaHCO3, NH4Cl, HCl, and total As method) for estimating As
bioavailability in soil based on a greenhouse experiment using Brassica
chinensis grown in various soils from 15 provinces in China. In addition,
we assessed whether these methods are independent of soil properties. The
correlations between plant and soil As concentration measured with
traditional extraction techniques were pH and iron oxide (Feox) dependent,
indicating that these methods are influenced by soil properties. In
contrast, DGT measurements were independent of soil properties and also
showed a better correlation coefficient than other traditional techniques.
Thus, DGT technique is superior to traditional techniques and should be
preferable for evaluating As bioavailability in different type of soils.
KW - Arsenic
KW - Bioavailability
KW - Brassica chinensis
KW - DGT
KW - Traditional extraction methods
RN - 1K09F3G675
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Comparative Study
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180321
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171006
STAT- MEDLINE
DOCNO- medline/29032263

213 - TOXLINE
TI - Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis
factor-alpha- through reactive oxygen species.
AU - Singhirunnusorn P
AD - Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute,
Thailand.
AU - Moolmuang B
AD - Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute,
Thailand.
AU - Lirdprapamongkol K
AD - Laboratory of Biochemistry, Chulabhorn Research Institute, Thailand.
AU - Ruchirawat M
AD - Laboratory of Environmental Toxicology, Chulabhorn Research Institute,
Thailand.
SO - J Toxicol Sci. 2018; 43(2):159-169. [The Journal of toxicological
sciences]
AB - Tumor necrosis factor-alpha (TNF-&alpha;) is a proinflammatory cytokine
released by immune cells during inflammation process. Sodium arsenite
(NaAsO2) is an environmental toxic metal. The effects of excess NaAsO2 on
TNF-&alpha; response and its intracellular signaling are not well
understood. We hypothesized that NaAsO2 exposure might affect cellular
response to TNF-&alpha;. Using HeLa cell model, we found that the
combination of NaAsO2 and TNF-&alpha; clearly decreased cell viability and
mitochondrial membrane potential, but increased percentage of early and
late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP).
Moreover, the combination prolonged the phosphorylation of
mitogen-activated protein kinase (MAPK) members, including
c-Jun-N-terminal kinase (JNK), p38, and extracellular signal related
kinases (ERK), and increased intracellular reactive oxygen species (ROS),
in comparison to treatment of NaAsO2 or TNF-&alpha; alone. We further
investigated the role of ROS and MAPK signaling on this event by
inhibiting ROS production and MAPK. An antioxidant N-acetylcysteine
pretreatment diminished the apoptosis-inducing effect of NaAsO2 and
TNF-&alpha; combination and also inhibited MAPK signaling. Using specific
inhibitor of p38 (SB203580) and siRNA-p38 surprisingly increased cell
apoptosis and this effect was not observed by JNK and ERK inhibition. This
study suggests that p38 may possibly be a survival mediator in response to
environmental toxicant-related inflammation. In conclusion, NaAsO2
exposure might amplify inflammation-related tissue injury by potentiating
the apoptosis-inducing effect of TNF-&alpha; through ROS-dependent
mechanism.
KW - Apoptosis
KW - MAPK signaling pathway
KW - Reactive oxygen species
KW - Sodium arsenite (NaAsO2)
KW - Tumor necrosis factor-alpha (TNF-α)
RN - 7XO134LHLN
RN - EC 2.7.11.24
LA - eng
IS - 1880-3989 (Electronic)
PT - Journal Article
TA - J Toxicol Sci
YR - 2018
DATE- 20180419
CITO- NLM
CS - Japan
CSET- IM
FJT - The Journal of toxicological sciences
STAT- MEDLINE
DOCNO- medline/29479036

214 - TOXLINE
TI - Hepatic histopathological changes and dysfunction in primates following
exposure to organic arsenic diphenylarsinic acid.
AU - Masuda T
AD - Department of Neurobiology, Faculty of Medicine, University of Tsukuba.
AU - Ishii K
AD - Department of Neurology, Faculty of Medicine, University of Tsukuba.
AU - Morishita Y
AD - Department of Diagnostic Pathology, Tokyo Medical University Ibaraki Medical
Center.
AU - Iwasaki N
AD - Department of Pediatrics, Ibaraki Prefectural University of Health Sciences.
AU - Shibata Y
AD - Center for Environmental Measurement and Analysis, National Institute for
Environmental Studiesan.
AU - Tamaoka A
AD - Department of Neurology, Faculty of Medicine, University of Tsukuba.
SO - J Toxicol Sci. 2018; 43(5):291-298. [The Journal of toxicological
sciences]
AB - Organic arsenic diphenylarsinic acid (DPAA[V]) accumulates at high
concentrations in the liver of primates after its subchronic
administration. However, no studies on the hepatic effects of organic
arsenic compounds, including DPAA(V), on primates have been reported to
date. To clarify the toxicokinetics of DPAA(V) in the liver of primates,
hepatic tissue specimens were collected from cynomolgus monkeys (n = 32)
at 5, 29, 170, and 339 days after repeated administration of DPAA(V) for
28 days. Four histopathological changes in the specimens were observed and
pathologically evaluated. Atypical ductular proliferation was found in the
DPAA(V)-exposed liver throughout the period. Inflammatory cell
infiltration in Glisson's capsules and lipid droplets were seen at earlier
periods after administration. Conversely, inflammatory cell infiltration
in liver lobules was seen later after administration. In this experiment,
we did not confirm the hepatic dysfunction of DPAA(V)-exposed monkeys by
blood chemistry tests. To compensate for this, we further investigated the
blood from a patient who exhibited several neurological symptoms after
DPAA(V) exposure. Her blood chemistry test values for aspartate
transaminase, alanine transaminase, and lactate dehydrogenase were
elevated, suggesting that her liver may have been damaged by DPAA(V)
exposure. Together, these findings suggest that the accumulation of
DPAA(V) may induce differential histopathological changes in primate
hepatocytes, resulting in decreased liver function. This is the first
report to investigate the liver of primates pathologically after exposure
to organic arsenic DPAA(V). Our findings will help expand our knowledge
regarding the effect of DPAA(V) on the liver of primates.
KW - Hepatic damage
KW - Hepatic pathology
KW - Long-term exposure
KW - Macaca fascicularis
KW - Phenyl arsenic compound
KW - Primate
LA - eng
IS - 1880-3989 (Electronic)
PT - Journal Article
TA - J Toxicol Sci
YR - 2018
DATE- 20180510
CITO- NLM
CS - Japan
FJT - The Journal of toxicological sciences
STAT- In-Process
DOCNO- medline/29743440

215 - TOXLINE
TI - Assessment of the exposure to heavy metals and arsenic in captive and
free-living black kites (Milvus migrans) nesting in Portugal.
AU - Carneiro M
AD - Center for the Research and Technology of Agro-Environmental and Biological
Sciences, University of Tr�s-os-Montes e Alto Douro, Quinta dos Prados, 5000-801,
Vila Real, Portugal.
AU - Oliveira P
AD - Center for the Research and Technology of Agro-Environmental and Biological
Sciences, University of Tr�s-os-Montes e Alto Douro, Quinta dos Prados, 5000-801,
Vila Real, Portugal; Department of Veterinary Sciences, ECAV, University of Tr�s-
os-Montes e Alto Douro, Quinta dos Prados, 5000-801 Vila Real, Portugal.
AU - Brand�o R
AD - Ecology, Monitoring and Recovery Centre of Wild Animals, 6290-909 Gouveia,
Portugal.
AU - Soeiro V
AD - Wildlife Rehabilitation Center of the Gaia Biological Park, 4430-681 Avintes,
Portugal.
AU - Pires MJ
AD - Center for the Research and Technology of Agro-Environmental and Biological
Sciences, University of Tr�s-os-Montes e Alto Douro, Quinta dos Prados, 5000-801,
Vila Real, Portugal; Department of Veterinary Sciences, ECAV, University of Tr�s-
os-Montes e Alto Douro, Quinta dos Prados, 5000-801 Vila Real, Portugal.
AU - Lavin S
AD - Servei d'Ecopatologia de Fauna Salvatge, Department of Medicine and Animal
Surgery, Autonomous, University of Barcelona, 08193 Bellaterra, Barcelona, Spain.
AU - Cola�o B
AD - Center for the Research and Technology of Agro-Environmental and Biological
Sciences, University of Tr�s-os-Montes e Alto Douro, Quinta dos Prados, 5000-801,
Vila Real, Portugal; Department of Zootechnics, Escola de Ci�ncias Agr�rias e
Veterin�rias, University of Tr�s-os-Montes e Alto Douro, Quinta dos Prados, 5000-
801 Vila Real, Portugal. Electronic address: bcolaco@utad.pt.
SO - Ecotoxicol Environ Saf. 2018, Sep 30; 160:191-196. [Ecotoxicology and
environmental safety]
AB - Due to their high trophic level, raptor species may serve as important
indicators of environmental contamination by heavy metals. This study was
conducted to determine if the habitat of the black kite (Milvus migrans)
is contaminated by heavy metals and arsenic and to assess the degree and
type of exposure that may be present. For this purpose, this study was
conducted on a group of captive birds (n&#8239;=&#8239;12) and on a group
of free-living birds admitted to two wildlife rehabilitation centers
(n&#8239;=&#8239;31). Blood samples were taken for analysis of arsenic
(As), mercury (Hg) and lead (Pb) concentrations by inductively coupled
plasma mass spectrometry (ICP-MS). Captive birds had the lowest blood
concentrations for all toxic elements examined, but significant
differences from the concentrations found in free-living birds were only
observed for Hg and Pb (p&#8239; < &#8239;0.01). Arsenic concentrations
were almost three times higher in free-living birds
(4.521&#8239;&plusmn;&#8239;5.695&#8239;&micro;g/dl) then in captive birds
(1.566&#8239;&plusmn;&#8239;0.753&#8239;&micro;g/dl). In all the samples
of captive birds' mercury was not detected, while in free-living birds we
observed a concentration of
7.493&#8239;&plusmn;&#8239;8.464&#8239;&micro;g/dl
(p&#8239; < &#8239;0.01). Regarding lead, we observed a concentration
almost four-fold higher in free-living birds
(19.430&#8239;&plusmn;&#8239;29.294&#8239;&micro;g/dl) then in captive
birds (4.449&#8239;&plusmn;&#8239;1.987&#8239;&micro;g/dl)
(p&#8239; < &#8239;0.01). Therefore, available sources of Pb and Hg seem
to be present in the habitat of the black kite.
KW - Blood
KW - Heavy metals
KW - Metalloids
KW - Milvus migrans
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180607
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180526
STAT- In-Process
DOCNO- medline/29804016

216 - TOXLINE
TI - Catalytic efficiency is a better predictor of arsenic toxicity to soil
alkaline phosphatase.
AU - Wang Z
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, Shaanxi 712100, China; Rocky desertification research
institute, Southwest Forestry University, Kunming, Yunnan 650224, China.
AU - Tian H
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, Shaanxi 712100, China.
AU - Lu G
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, Shaanxi 712100, China.
AU - Zhao Y
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, Shaanxi 712100, China.
AU - Yang R
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, Shaanxi 712100, China.
AU - Megharaj M
AD - Global Centre for Environmental Remediation, Faculty of Science, University
of Newcastle, Callaghan, NSW 2308, Australia.
AU - He W
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, Shaanxi 712100, China. Electronic address:
wenxiang.he@nwafu.edu.cn.
SO - Ecotoxicol Environ Saf. 2018, Feb; 148:721-728. [Ecotoxicology and
environmental safety]
AB - Arsenic (As) is an inhibitor of phosphatase, however, in the complex soil
system, the substrate concentration effect and the mechanism of As
inhibition of soil alkaline phosphatase (ALP) and its kinetics has not
been adequately studied. In this work, we investigated soil ALP activity
in response to As pollution at different substrate concentrations in
various types of soils and explored the inhibition mechanism using the
enzyme kinetics. The results showed that As inhibition of soil ALP
activity was substrate concentration-dependent. Increasing substrate
concentration decreased inhibition rate, suggesting reduced toxicity. This
dependency was due to the competitive inhibition mechanism of As to soil
ALP. The kinetic parameters, maximum reaction velocity (Vmax) and
Michaelis constant (Km) in unpolluted soils were 0.012-0.267mMh-1 and
1.34-3.79mM respectively. The competitive inhibition constant (Kic) was
0.17-0.70mM, which was lower than Km, suggesting higher enzyme affinity
for As than for substrate. The ecological doses, ED10 and ED50
(concentration of As that results in 10% and 50% inhibition on enzyme
parameter) for inhibition of catalytic efficiency (Vmax/Km) were lower
than those for inhibition of enzyme activity at different substrate
concentrations. This suggests that the integrated kinetic parameter,
catalytic efficiency is substrate concentration independent and more
sensitive to As than ALP activity. Thus, catalytic efficiency was proposed
as a more reliable indicator than ALP activity for risk assessment of As
pollution.
KW - Arsenic
KW - Bioindicator
KW - Ecological dose
KW - Enzyme kinetics
KW - Soil alkaline phosphatase
RN - 701-64-4
RN - EC 3.1.3.1
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180517
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171123
STAT- MEDLINE
DOCNO- medline/29175755

217 - TOXLINE
TI - Copper interactions on arsenic bioavailability and phytotoxicity in soil.
AU - Kader M
AD - Global Centre for Environmental Remediation (GCER), The University of
Newcastle (UoN), Callaghan, NSW 2308, Australia; Cooperative Research Centre for
Contamination Assessment and Remediation of the Environment (CRC CARE), Advanced
Technology Centre Building, University Drive, Callaghan, NSW 2308, Australia.
AU - Lamb DT
AD - Global Centre for Environmental Remediation (GCER), The University of
Newcastle (UoN), Callaghan, NSW 2308, Australia; Cooperative Research Centre for
Contamination Assessment and Remediation of the Environment (CRC CARE), Advanced
Technology Centre Building, University Drive, Callaghan, NSW 2308, Australia.
Electronic address: dane.lamb@newcastle.edu.au.
AU - Wang L
AD - Global Centre for Environmental Remediation (GCER), The University of
Newcastle (UoN), Callaghan, NSW 2308, Australia; Cooperative Research Centre for
Contamination Assessment and Remediation of the Environment (CRC CARE), Advanced
Technology Centre Building, University Drive, Callaghan, NSW 2308, Australia.
AU - Megharaj M
AD - Global Centre for Environmental Remediation (GCER), The University of
Newcastle (UoN), Callaghan, NSW 2308, Australia; Cooperative Research Centre for
Contamination Assessment and Remediation of the Environment (CRC CARE), Advanced
Technology Centre Building, University Drive, Callaghan, NSW 2308, Australia.
AU - Naidu R
AD - Global Centre for Environmental Remediation (GCER), The University of
Newcastle (UoN), Callaghan, NSW 2308, Australia; Cooperative Research Centre for
Contamination Assessment and Remediation of the Environment (CRC CARE), Advanced
Technology Centre Building, University Drive, Callaghan, NSW 2308, Australia.
SO - Ecotoxicol Environ Saf. 2018, Feb; 148:738-746. [Ecotoxicology and
environmental safety]
AB - Arsenic (As) and copper (Cu) are co-contaminants in the environment but
little is known about their ecological impact as mixtures in soil. In this
study, we investigated the combined As-Cu interactions on toxicity and
uptake as binary mixtures in 5 contrasting soils. The study included
solubility, contaminant uptake and toxicity in cucumber (Cucumis sativus
L.) as a model plant species. Soils were spiked individually and as a
mixtures at 10 different As levels (2, 4, 8 up to 1024mgkg-1). Copper was
added with As at two effective concentration levels (EC10Cu and EC50Cu).
Arsenic uptake was significantly reduced in the presence of Cu and a
higher effect was demonstrated with increasing pore-water pH. Copper
accumulation was not significantly influenced by As. An additive response
on plant growth was predominant overall when expressed from pore-water
parameters with root mean square errors of 12.6 and 13.2 for EC10Cu and
EC50Cu treatments, respectively.
KW - Bioaccumulation
KW - Bioavailability
KW - Phytotoxicity
KW - Pore-water
RN - 059QF0KO0R
RN - 789U1901C5
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180517
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171125
STAT- MEDLINE
DOCNO- medline/29179146

218 - TOXLINE
TI - Mass balance of arsenic fluxes in rivers impacted by gold mining
activities in Paracatu (Minas Gerais State, Brazil).
AU - Bidone E
AD - UFF, Department of Environmental Geochemistry, Fluminense Federal University,
Outeiro S�o Jo�o Baptista, s/n. Centro, Niter�i, Rio de Janeiro, Brazil.
ebidone@yahoo.com.br.
AU - Cesar R
AD - UFRJ, Department of Geography, Federal University of Rio de Janeiro, Av.
Athos da Silveira Ramos, 274 - Cidade Universit�ria, Rio de Janeiro, Rio de
Janeiro, Brazil.
AU - Santos MC
AD - UFF, Department of Environmental Geochemistry, Fluminense Federal University,
Outeiro S�o Jo�o Baptista, s/n. Centro, Niter�i, Rio de Janeiro, Brazil.
AU - Sierpe R
AD - UFF, Department of Environmental Geochemistry, Fluminense Federal University,
Outeiro S�o Jo�o Baptista, s/n. Centro, Niter�i, Rio de Janeiro, Brazil.
AU - Silva-Filho EV
AD - UFF, Department of Environmental Geochemistry, Fluminense Federal University,
Outeiro S�o Jo�o Baptista, s/n. Centro, Niter�i, Rio de Janeiro, Brazil.
AU - Kutter V
AD - UFF, Department of Environmental Geochemistry, Fluminense Federal University,
Outeiro S�o Jo�o Baptista, s/n. Centro, Niter�i, Rio de Janeiro, Brazil.
AU - Dias da Silva LI
AD - Centre for Mineral Technology, CETEM/MCTI, Av. Pedro Calmon, 900. Cidade
Universit�ria, Rio de Janeiro, Rio de Janeiro, Brazil.
AU - Castilhos Z
AD - Centre for Mineral Technology, CETEM/MCTI, Av. Pedro Calmon, 900. Cidade
Universit�ria, Rio de Janeiro, Rio de Janeiro, Brazil.
SO - Environ Sci Pollut Res Int. 2018, Mar; 25(9):9085-9100. [Environmental
science and pollution research international]
AB - Arsenic (As) is a dangerous and carcinogenic element and drinking water is
its main pathway of human exposure. Gold mines are widely recognized as
important sources of As pollution. This work proposes the assessment of As
distribution along watersheds surrounding "Morro do Ouro" gold mine
(Paracatu, southeastern Brazil). A balance approach between filtered As
fluxes (As&thinsp; < &thinsp;0.45 &mu;m) and suspended particulate
material (AsSPM) in different river segments was applied. Ultrafiltration
procedure was used to categorize As into the following classes:
particulate > &thinsp;0.1 &mu;m, colloidal
< &thinsp;0.1 &mu;m to > &thinsp;10 kDa, dissolved
< &thinsp;10 kDa to > &thinsp;1 kDa, and truly dissolved
< &thinsp;1 kDa. By applying this approach, arsenic contributions
from mining facilities were quantified in order to identify critical
fluvial segments and support decision makers in actions of remediation.
The mass balance indicated the occurrence of a decreasing gradient from
upstream to downstream: (i) of the As concentrations higher than the limit
established by Brazilian law (10 &mu;g L-1); (ii) of the ratio
between specific fluxes (g As km-2 day-1) and those determined
using an uncontaminated watershed (a proxy for estimating the anthropic
contribution), from 103 to 101; (iii) of the specific fluxes
As&thinsp; < &thinsp;0.45 &mu;m and AsSPM from 102 to 100; and (iv)
of the negative balance output minus input for each river segment that
suggests As accumulation in sediments along the rivers in both urban and
rural areas, mainly due to SPM sedimentation and sorption by Fe
oxyhydroxides. Ultrafiltration shattering showed concentrations of
decreasing As with particle size; the SPM load
( > &thinsp;0.1 &mu;m) was almost one order higher to dissolved load
( < &thinsp;1 kDa).
KW - Arsenic pollution
KW - Gold mine
KW - Mass balance
KW - River water
KW - Ultrafiltration
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180318
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180116
STAT- In-Process
CM - Cites: Environ Sci Pollut Res Int. 2016 May;23 (9):8546-55 (medline
/26797944)
CM - Cites: Anal Chim Acta. 2007 Aug 13;598(1):162-8 (medline /17693321)
CM - Cites: Environ Int. 2009 Nov;35(8):1243-55 (medline /19665230)
CM - Cites: Environ Sci Technol. 2006 Jun 15;40(12):3901-5 (medline /16830559)
CM - Cites: Water Res. 2003 Jul;37(12):2929-36 (medline /12767295)
CM - Cites: Environ Sci Technol. 2006 Feb 15;40(4):1364-70 (medline /16572798)
CM - Cites: Environ Monit Assess. 2007 Aug;131(1-3):371-6 (medline /17106769)
CM - Cites: Anal Bioanal Chem. 2003 Apr;375(8):1097-100 (medline /12733022)
CM - Cites: Environ Sci Technol. 2002 Apr 15;36(8):1712-9 (medline /11993868)
CM - Cites: Talanta. 2015 Mar;134:530-7 (medline /25618704)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2013;48(6):620-8 (medline /23442113)
CM - Cites: Environ Sci Technol. 2011 Jan 15;45(2):546-53 (medline /21142173)
CM - Cites: Annu Rev Earth Planet Sci. 2014 May 1;42:443-467 (medline
/26778863)
CM - Cites: J Hazard Mater. 2007 Apr 2;142(1-2):1-53 (medline /17324507)
CM - Cites: Environ Sci Technol. 2011 Nov 15;45(22):9550-7 (medline /21985502)
CM - Cites: Chemosphere. 2005 Dec;61(10):1458-67 (medline /16038963)
CM - Cites: Water Res. 2013 Jun 1;47(9):2938-48 (medline /23566332)
CM - Cites: Environ Monit Assess. 2011 Oct;181(1-4):165-73 (medline /21161585)
CM - Cites: Environ Sci Technol. 2006 Oct 1;40(19):6015-20 (medline /17051793)
CM - Cites: Environ Sci Technol. 2003 Sep 15;37(18):4182-9 (medline /14524451)
CM - Cites: Chemosphere. 2016 Dec;164:290-298 (medline /27592318)
DOCNO- medline/29335874

219 - TOXLINE
TI - Arsenic speciation in fish and shellfish from the North Sea (Southern
bight) and A�u Port area (Brazil) and health risks related to
seafood consumption.
AU - Gao Y
AD - Analytical, Environmental and Geochemical Department (AMGC), Vrije
Universiteit Brussel, Brussels, Belgium. Electronic address: yuegao@vub.ac.be.
AU - Baisch P
AD - Laborat�rio de Oceanografia Geol�gica, Instituto de Oceanografia,
Universidade Federal do Rio Grande (FURG), Campus Carreiros, CP 474, CEP 96203-900
Rio Grande, RS, Brazil.
AU - Mirlean N
AD - Laborat�rio de Oceanografia Geol�gica, Instituto de Oceanografia,
Universidade Federal do Rio Grande (FURG), Campus Carreiros, CP 474, CEP 96203-900
Rio Grande, RS, Brazil.
AU - Rodrigues da Silva J�nior FM
AD - Laborat�rio de Ensaios Farmacol�gicos e Toxicol�gicos, Instituto de Ci�ncias
Biol�gicas, Universidade Federal do Rio Grande (FURG), Campus Carreiros, CP 474,
CEP 96203-900 Rio Grande, RS, Brazil.
AU - Van Larebeke N
AD - Analytical, Environmental and Geochemical Department (AMGC), Vrije
Universiteit Brussel, Brussels, Belgium.
AU - Baeyens W
AD - Analytical, Environmental and Geochemical Department (AMGC), Vrije
Universiteit Brussel, Brussels, Belgium.
AU - Leermakers M
AD - Analytical, Environmental and Geochemical Department (AMGC), Vrije
Universiteit Brussel, Brussels, Belgium.
SO - Chemosphere. 2018, Jan; 191:89-96. [Chemosphere]
AB - In North Sea and Port A�u (Brazil) coastal areas, high arsenic (As)
concentrations were observed in water, soil and sediments. Therefore, the
impact of this contamination on fish and shellfish species bought from
local fishermen was studied. Total As was assessed with ICP-OES (Brazil)
and ICP-MS (North Sea) after microwave digestion. Toxic As was assessed
with liquid chromatography-ICP-MS (Brazil) and hydride generation-atomic
fluorescence spectrometry (North Sea). All analytical methods comply with
Quality Assurance/Quality Control procedures. Several fish species have
average Total As concentrations above 1 &mu;g g-1 wet weight (ww),
but the highest concentrations are found in less spotted dogfish, lemon
sole and whelks from the North Sea, with respectively 50, 49 and
50 &mu;g g-1 ww. High Total As concentrations correspond to high
Toxic As concentrations, except for scallops having increased Toxic As
concentrations. Toxic As fractions are highest in scallops (almost 10%)
but rarely exceeds 2% in all other species. Liver samples were only
analyzed in ray, dogfish and catfish and their Toxic As fractions are
between 2 and 4 times higher than in muscle. For a consumption of
150 g of seafood, only 3 samples exceed the provisional total daily
intake of 2 &mu;g kg-1 bw, however, cancer risks are non-negligible.
Using mean Toxic As concentrations for each of the different fish and
shellfish species studied, Lifetime Cancer Risk values at the actual
global seafood consumption rate of 54 g day-1 are above 10-4 for
whelks, scallops, dogfish, ray and lemon sole.
KW - Arsenic speciation
KW - Brazil
KW - Cancer risk
KW - Fish and shellfish
KW - North sea
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180315
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171007
STAT- MEDLINE
DOCNO- medline/29031057

220 - TOXLINE
TI - Combined effects of arsenic, salinity and temperature on Crassostrea gigas
embryotoxicity.
AU - Moreira A
AD - Departmento de Biologia &amp; CESAM, Universidade de Aveiro, Campus
Universit�rio de Santiago, 3810-193 Aveiro, Portugal.
AU - Freitas R
AD - Departmento de Biologia &amp; CESAM, Universidade de Aveiro, Campus
Universit�rio de Santiago, 3810-193 Aveiro, Portugal.
AU - Figueira E
AD - Departmento de Biologia &amp; CESAM, Universidade de Aveiro, Campus
Universit�rio de Santiago, 3810-193 Aveiro, Portugal.
AU - Volpi Ghirardini A
AD - Department of Environmental Sciences, Informatics and Statistics, University
C� Foscari Venice, Via Torino 155, 30172 Venezia-Mestre, Italy.
AU - Soares AMVM
AD - Departmento de Biologia &amp; CESAM, Universidade de Aveiro, Campus
Universit�rio de Santiago, 3810-193 Aveiro, Portugal.
AU - Radaelli M
AD - Department of Environmental Sciences, Informatics and Statistics, University
C� Foscari Venice, Via Torino 155, 30172 Venezia-Mestre, Italy.
AU - Guida M
AD - Department of Biology, University of Naples Federico II, Complesso
Universitario di Monte S. Angelo, Via Cinthia ed. 7, 80126 Naples, Italy.
AU - Libralato G
AD - Department of Environmental Sciences, Informatics and Statistics, University
C� Foscari Venice, Via Torino 155, 30172 Venezia-Mestre, Italy; Department of
Biology, University of Naples Federico II, Complesso Universitario di Monte S.
Angelo, Via Cinthia ed. 7, 80126 Naples, Italy. Electronic address:
giovanni.libralato@unina.it.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:251-259. [Ecotoxicology and
environmental safety]
AB - The combined effects of different salinity and temperature levels on the
toxicity of Arsenic (As) were studied on the embryonic development of the
oyster Crassostrea gigas. A standardized embryotoxicity test was performed
to assess the interactive effects of these stressors, in a full factorial
design experiment including a range of salinities (15, 19, 24, 28 and 32),
temperatures (16, 20, 24, 28 and 32&deg;C) and As concentrations (100,
300, 600, 1200, 2400&micro;gL-1). The embryotoxicity endpoint was about
the determination of normal larvae development rates at various
conditions, and median effect concentration (EC50) determination for each
As exposure condition. Results showed that toxicity induced by As was
characterized by retardation of embryonic development observing toxic
effects at lower concentrations than previously reported studies. The
presence of As in seawater resulted in a narrower range of tolerance to
both salinity and temperature. These findings bring new insights on the
impacts of a common contaminant on an important shellfish species having a
planktonic early life stage development, with potential implications for
population survival and ecosystem functioning in a changing environment.
KW - Arsenic
KW - Crassostrea gigas
KW - Embryo development
KW - Salinity
KW - Temperature
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180314
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20170914
STAT- MEDLINE
DOCNO- medline/28846930

221 - TOXLINE
TI - Iron oxide - clay composite vectors on long-distance transport of arsenic
and toxic metals in mining-affected areas.
AU - Gomez-Gonzalez MA
AD - Museo Nacional de Ciencias Naturales (MNCN, CSIC), C/ Jose Gutierrez Abascal
2, 28006, Madrid, Spain.
AU - Villalobos M
AD - Instituto de Geolog�a, Universidad Nacional Aut�noma de M�xico (UNAM),
Coyoac�n, D.F. 04510, Mexico.
AU - Marco JF
AD - Instituto de Qu�mica F�sica-Rocasolano (CSIC), C/ Serrano 119, 28006, Madrid,
Spain.
AU - Garcia-Guinea J
AD - Museo Nacional de Ciencias Naturales (MNCN, CSIC), C/ Jose Gutierrez Abascal
2, 28006, Madrid, Spain.
AU - Bolea E
AD - Instituto Universitario de Ciencias Ambientales (IUCA), Universidad de
Zaragoza, C/ Pedro Cerbuna 12, 50009, Zaragoza, Spain.
AU - Laborda F
AD - Instituto Universitario de Ciencias Ambientales (IUCA), Universidad de
Zaragoza, C/ Pedro Cerbuna 12, 50009, Zaragoza, Spain.
AU - Garrido F
AD - Museo Nacional de Ciencias Naturales (MNCN, CSIC), C/ Jose Gutierrez Abascal
2, 28006, Madrid, Spain. Electronic address: fernando.garrido@mncn.csic.es.
SO - Chemosphere. 2018, Apr; 197:759-767. [Chemosphere]
AB - Mine wastes from abandoned exploitations are sources of high
concentrations of hazardous metal(oid)s. Although these contaminants can
be attenuated by sorbing to secondary minerals, in this work we identified
a mechanism for long-distance dispersion of arsenic and metals through
their association to mobile colloids. We characterize the colloids and
their sorbed contaminants using spectrometric and physicochemical
fractionation techniques. Mechanical action through erosion may release
and transport high concentrations of colloid-associated metal(oid)s
towards nearby stream waters, promoting their dispersion from the
contamination source. Poorly crystalline ferrihydrite acts as the
principal As-sorbing mineral, but in this study we find that this
nanomineral does not mobilize As independently, rather, it is transported
as surface coatings bound to mineral particles, perhaps through
electrostatic biding interactions due to opposing surface charges at
acidic to circumneutral pH values. This association is very stable and
effective in carrying along metal(oid)s in concentrations above regulatory
levels. The unlimited source of toxic elements in mine residues causes
ongoing, decades-long mobilization of toxic elements into stream waters.
The ferrihydrite-clay colloidal composites and their high mobility limit
the attenuating role that iron oxides alone show through adsorption of
metal(oid)s and their immobilization in situ. This may have important
implications for the potential bioavailability of these contaminants, as
well as for the use of this water for human consumption.
KW - AF4-ICP-MS
KW - Arsenic
KW - Colloids
KW - Fe-coatings
KW - Mine residues
KW - XAS
RN - 1302-87-0
RN - 1K09F3G675
RN - 87PZU03K0K
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180613
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180203
STAT- MEDLINE
DOCNO- medline/29407840

222 - TOXLINE
TI - Aqueous extract of Carica papaya Linn. roots potentially attenuates
arsenic induced biochemical and genotoxic effects in Wistar rats.
AU - Ojo OA
AD - Phytomedicine, Biochemical Toxicology and Diabetes Research Laboratories,
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State,
Nigeria.
AU - Ojo AB
AD - Department of Medical Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti
State, Nigeria.
AU - Awoyinka O
AD - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Ekiti
State University, Ado-Ekiti, Nigeria.
AU - Ajiboye BO
AD - Phytomedicine, Biochemical Toxicology and Diabetes Research Laboratories,
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State,
Nigeria.
AU - Oyinloye BE
AD - Phytomedicine, Biochemical Toxicology and Diabetes Research Laboratories,
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State,
Nigeria.
AU - Osukoya OA
AD - Phytomedicine, Biochemical Toxicology and Diabetes Research Laboratories,
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State,
Nigeria.
AU - Olayide II
AD - Phytomedicine, Biochemical Toxicology and Diabetes Research Laboratories,
Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State,
Nigeria.
AU - Ibitayo A
AD - Department of Biological Sciences, Afe Babalola University, Ado-Ekiti, Ekiti
State, Nigeria.
SO - J Tradit Complement Med. 2018, Apr; 8(2):324-334. [Journal of traditional
and complementary medicine]
AB - In Africa, the fruit, leaf, seed and roots of Carica papaya Linn. are
generally used to treat a variety of diseases such as malaria, cancer, and
cardiovascular diseases. In this study, we evaluated the protective
potentials of aqueous extract of C. papaya roots on arsenic-induced
biochemical and genotoxic effects in Wistar rats. Rats were induced
intraperitoneal with sodium arsenate (dissolved in distilled water at
3 mg/kg body weight) for 21 days and the animals were administered
simultaneously with 200 mg/kg body weight vitamin C, 100 and
150 mg/kg body weight of the C. papaya Linn. root aqueous
extract once daily for three weeks. Results obtained reveals that
activities of plasma 8-OHdG, serum lipids concentration, atherogenic index
(AI), coronary artery index (CRI), aspartate transaminase, alanine
transaminase, alkaline phosphatase, total bilirubin levels were elevated
significantly (p < 0.05) and catalase, glutathione
peroxidase, superoxide dismutase, plasma hematological profile were
progressively reduced (p < 0.05) in arsenic-alone exposed
rats. Significant increase in the quantity of chromosomal aberrations
(CA), micronuclei (MN) frequency, oxidative damages in the bone marrow
cells from arsenic alone rats was observed. Though, mitotic index scores
in these cells were progressively reduced (p < 0.05). In
animals administered with aqueous extract of C. papaya roots and
vitamin C, the altered parameters were significantly recovered towards the
levels observed in normal control rats. These results suggest that aqueous
C. papaya roots preparations might have therapeutic potential as a
supplement that can be applied in arsenic poisoning.
KW - 8-OHdG
KW - Arsenic
KW - Blood lipid profile
KW - Carica papaya Linn. root extract
KW - Chromosomal aberrations
KW - DNA damage
KW - Genotoxicity
KW - Liver antioxidant enzymes
LA - eng
IS - 2225-4110 (Print)
PT - Journal Article
TA - J Tradit Complement Med
YR - 2018
DATE- 20180509
CITO- NLM
CS - Netherlands
FJT - Journal of traditional and complementary medicine
EDAT- 20170909
STAT- PubMed-not-MEDLINE
CM - Cites: Clin Chem. 1972 Jun;18(6):499-502 (medline /4337382)
CM - Cites: Interdiscip Toxicol. 2014 Dec;7(4):208-14 (medline /26109902)
CM - Cites: Toxicol Sci. 2000 Jun;55(2):460-7 (medline /10828279)
CM - Cites: J Nutr. 1974 May;104(5):580-7 (medline /4823943)
CM - Cites: Am J Epidemiol. 2001 Mar 1;153(5):411-8 (medline /11226969)
CM - Cites: Biotech Histochem. 1993 Jul;68(4):187-8 (medline /8218570)
CM - Cites: Mol Cancer. 2008 May 28;7:45 (medline /18505595)
CM - Cites: Toxicol Lett. 2003 Jan 31;137(1-2):15-21 (medline /12505429)
CM - Cites: Microchem J. 2012 Nov 1;105:101-107 (medline /23175155)
CM - Cites: Free Radic Biol Med. 1987;3(6):379-87 (medline /3123331)
CM - Cites: Environ Res. 2001 Feb;85(2):69-76 (medline /11161656)
CM - Cites: Pharmacogn Mag. 2016 May;12(Suppl 2):S170-4 (medline /27279703)
CM - Cites: Mol Cell Biochem. 2001 Jun;222(1-2):49-59 (medline /11678611)
CM - Cites: J Ethnopharmacol. 2015 Dec 4;175:509-17 (medline /26456329)
CM - Cites: J Complement Integr Med. 2017 Mar 17;14 (3):null (medline
/28306534)
CM - Cites: Postgrad Med J. 2003 Jul;79(933):391-6 (medline /12897217)
CM - Cites: Toxicol Pathol. 2004 Jan-Feb;32(1):64-72 (medline /14713550)
CM - Cites: Ann Rheum Dis. 2003 Sep;62(9):842-5 (medline /12922956)
CM - Cites: Food Chem Toxicol. 2001 Oct;39(10 ):1029-38 (medline /11524141)
CM - Cites: Mutat Res. 1991 Feb;262(2):115-8 (medline /2000096)
CM - Cites: Environ Health. 2011 Jul 08;10:64 (medline /21740555)
CM - Cites: Toxicol Appl Pharmacol. 2009 Nov 1;240(3):367-76 (medline
/19631675)
CM - Cites: Mutat Res. 1986 Oct;172(1):69-76 (medline /3762570)
CM - Cites: J Agric Food Chem. 2000 Aug;48(8):3396-402 (medline /10956123)
CM - Cites: Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1643-8 (medline
/11172004)
CM - Cites: Toxicol In Vitro. 2003 Oct-Dec;17(5-6):803-10 (medline /14599481)
CM - Cites: J Ethnopharmacol. 2010 Aug 9;130(3):465-9 (medline /20553830)
CM - Cites: Biotechnol Adv. 2015 Dec;33(8):1582-1614 (medline /26281720)
CM - Cites: Environ Toxicol. 2012 Mar;27(4):244-54 (medline /20725942)
CM - Cites: Indian J Exp Biol. 2006 Jan;44(1):39-44 (medline /16430089)
CM - Cites: Neurochem Res. 2005 Feb;30(2):225-35 (medline /15895826)
CM - Cites: Indian J Clin Biochem. 2010 Apr;25(2):127-32 (medline /23105898)
CM - Cites: Anticancer Res. 1991 Mar-Apr;11(2):489-527 (medline /1905900)
CM - Cites: Int J Hyg Environ Health. 2001 Mar;203(3):249-62 (medline
/11279822)
CM - Cites: Mutat Res. 1983 Oct;111(2):195-207 (medline /6633550)
CM - Cites: J Biol Chem. 1972 May 25;247(10):3170-5 (medline /4623845)
CM - Cites: Chem Biol Interact. 2009 Jun 15;180(1):20-30 (medline /19428342)
CM - Cites: Int J Radiat Biol. 1990 Nov;58(5):733-43 (medline /1977818)
CM - Cites: Anal Biochem. 1972 Jun;47(2):389-94 (medline /4556490)
CM - Cites: Acta Paediatr Taiwan. 1999 Sep-Oct;40(5):319-24 (medline /10910541)
CM - Cites: Hypertension. 1995 Jan;25(1):53-60 (medline /7843753)
CM - Cites: Toxicol Appl Pharmacol. 1991 Apr;108(2):205-13 (medline /2017750)
CM - Cites: Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8103-7 (medline
/9653147)
CM - Cites: Mutat Res. 1986 Dec;163(3):263-9 (medline /3785262)
CM - Cites: Environ Mutagen. 1986;8(1):119-28 (medline /3753679)
CM - Cites: Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 (medline
/11312654)
CM - Cites: Arch Environ Health. 1963 Mar;6:357-65 (medline /13936327)
CM - Cites: World Rev Nutr Diet. 1980;35:172-235 (medline /6994374)
CM - Cites: Environ Health Perspect. 1992 Jul;97:259-67 (medline /1396465)
CM - Cites: Proc Natl Acad Sci U S A. 1984 Jul;81(14):4343-7 (medline /6589599)
DOCNO- medline/29736388

223 - TOXLINE
TI - Arsenite-induced histone H3 modification and its effects on EGR1 and FOS
expression in HeLa cells.
AU - Suzuki T
AD - Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku,
Tokyo, 173-8605, Japan.
AU - Watanabe H
AD - Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku,
Tokyo, 173-8605, Japan.
AU - Kita K
AD - Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku,
Tokyo, 173-8605, Japan.
AU - Honma T
AD - Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku,
Tokyo, 173-8605, Japan.
AU - Ochi T
AD - Faculty of Pharma-Science, Teikyo University, 2-11-1 Kaga, Itabashi-ku,
Tokyo, 173-8605, Japan.
SO - J Appl Toxicol. 2018, May; 38(5):734-743. [Journal of applied toxicology :
JAT]
AB - It is evident that trivalent arsenicals do not have mutagenicity, but they
are human carcinogens. Recently, epigenetic modification has been
considered as one of the important causes of arsenical carcinogenicity.
Here we examined global histone H3 modification by trivalent inorganic
arsenite (iAs(III)) and its contribution to gene expression in HeLa cells.
iAs(III) induced histone H3K9 dimethylation (H3K9me2) and trimethylation
(H3K9me3), histone H3S10 phosphorylation (H3S10p), histone H3T11
phosphorylation (H3T11p) and histone H3K9S10 trimethyl-phosphorylation
(H3K9me3S10p). Among these modifications, H3S10p, H3T11p and H3K9me3S10p
were observed as a punctate signal in interphase cells, which seems to
associate with remodeling of the chromatin structure at the specific
locus. A chromatin immunoprecipitation assay was performed to examine
histone H3 modifications around the FOS, EGR1 and IL8 promoters, as
previous studies revealed some relation between histone H3 modification
and induction of these genes. iAs(III) increased H3S10p and H3K9me3S10p in
the FOS promoter around the SRE/ELK1 binding site (-400 to -200) and
CRE-binding site (-50). In contrast, histone H3 around the EGR1 promoter
of SRE/CRE-binding site (-200 to -50) was modified to H3S10p and
H3K9me3S10p by iAs(III). Reporter gene assays with deletion mutants of the
FOS and EGR1 promoters revealed that the around SRE/ELK1 site is important
for iAs(III)-mediated FOS induction, and SRE/CRE site for EGR1 induction.
Collectively, these results demonstrate that iAs(III) induces histone H3
modifications around the transcription factor binding sites of the FOS and
EGR1 promoter, and these modifications seem to be important in
transcriptional activation of these genes.
KW - EGR1
KW - FOS
KW - arsenite
KW - epigenetics
KW - histone H3 modification
LA - eng
IS - 1099-1263 (Electronic)
PT - Journal Article
TA - J Appl Toxicol
YR - 2018
DATE- 20180326
CI - Copyright &copy; 2018 John Wiley &amp; Sons, Ltd.
CITO- NLM
CS - England
FJT - Journal of applied toxicology : JAT
EDAT- 20180119
STAT- In-Data-Review
DOCNO- medline/29350772

224 - TOXLINE
TI - Effect of exogenous phosphate on the lability and phytoavailability of
arsenic in soils.
AU - Wang J
AD - Institute of Agricultural Environment and Sustainable Development, Chinese
Academy of Agriculture Sciences/Key Laboratory of Agro-Environment, Ministry of
Agriculture, Beijing, 100081, China; The College of Natural Resources and
Environment of South China Agricultural University/Key Laboratory of Arable Land
Conservation (South China), Ministry of Agriculture, Guangzhou, 510642, China.
AU - Zeng X
AD - Institute of Agricultural Environment and Sustainable Development, Chinese
Academy of Agriculture Sciences/Key Laboratory of Agro-Environment, Ministry of
Agriculture, Beijing, 100081, China. Electronic address: zengxibai@caas.cn.
AU - Zhang H
AD - Lancaster Environment Center, Lancaster University, LA1 4YQ, UK. Electronic
address: h.zhang@lancaster.ac.uk.
AU - Li Y
AD - The College of Natural Resources and Environment of South China Agricultural
University/Key Laboratory of Arable Land Conservation (South China), Ministry of
Agriculture, Guangzhou, 510642, China.
AU - Zhao S
AD - Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou,
510642, China.
AU - Su S
AD - Institute of Agricultural Environment and Sustainable Development, Chinese
Academy of Agriculture Sciences/Key Laboratory of Agro-Environment, Ministry of
Agriculture, Beijing, 100081, China.
AU - Bai L
AD - Institute of Agricultural Environment and Sustainable Development, Chinese
Academy of Agriculture Sciences/Key Laboratory of Agro-Environment, Ministry of
Agriculture, Beijing, 100081, China.
AU - Wang Y
AD - Institute of Agricultural Environment and Sustainable Development, Chinese
Academy of Agriculture Sciences/Key Laboratory of Agro-Environment, Ministry of
Agriculture, Beijing, 100081, China.
AU - Zhang T
AD - Institute of Agricultural Environment and Sustainable Development, Chinese
Academy of Agriculture Sciences/Key Laboratory of Agro-Environment, Ministry of
Agriculture, Beijing, 100081, China.
SO - Chemosphere. 2018, Apr; 196:540-547. [Chemosphere]
AB - The effect of exogenous phosphate (P, 200&#8239;mg&sdot;kg-1 soil) on the
lability and phytoavailability of arsenic (As) was studied using the
diffusive gradients in thin films (DGT) technique. Lettuce were grown on
the As-amended soils following the stabilization of soil labile As after
90 days incubation. Phosphate (P) application generally facilitated plant
growth except one grown on P-sufficient soil. Soil labile As concentration
increased in all the soils after P application due to a competition
effect. Plant As concentration increased in red soils collected from Hunan
Province, while decreases were observed in the other soils. Even though,
an overall trend of decrease was obtained in As phytoavailability along
with the increase of DGT-measured soil labile P/As molar ratio. The
functional equation between P/As and As phytoavailability provided a
critical value of 1.7, which could be used as a guidance for rational P
fertilization, thus avoiding overfertilization.
KW - Diffusive gradients in thin films
KW - Labile P/As molar ratio
KW - Phosphorus-arsenic interaction
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180312
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171230
STAT- MEDLINE
DOCNO- medline/29329086

225 - TOXLINE
TI - Pollution potential leaching index as a tool to assess water leaching risk
of arsenic in excavated urban soils.
AU - Li J
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan.
AU - Kosugi T
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan.
AU - Riya S
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan.
AU - Hashimoto Y
AD - Department of Bioapplications and Systems Engineering (BASE), Tokyo
University of Agriculture and Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588,
Japan.
AU - Hou H
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Dayangfang 8, Beijing 100012, PR China.
AU - Terada A
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan.
AU - Hosomi M
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan. Electronic address:
hosomi@cc.tuat.ac.jp.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:72-79. [Ecotoxicology and
environmental safety]
AB - Leaching of hazardous trace elements from excavated urban soils during
construction of cities has received considerable attention in recent years
in Japan. A new concept, the pollution potential leaching index (PPLI),
was applied to assess the risk of arsenic (As) leaching from excavated
soils. Sequential leaching tests (SLT) with two liquid-to-solid (L/S)
ratios (10 and 20Lkg-1) were conducted to determine the PPLI values, which
represent the critical cumulative L/S ratios at which the average As
concentrations in the cumulative leachates are reduced to critical values
(10 or 5&micro;gL-1). Two models (a logarithmic function model and an
empirical two-site first-order leaching model) were compared to estimate
the PPLI values. The fractionations of As before and after SLT were
extracted according to a five-step sequential extraction procedure. Ten
alkaline excavated soils were obtained from different construction
projects in Japan. Although their total As contents were low (from 6.75 to
79.4mgkg-1), the As leaching was not negligible. Different L/S ratios at
each step of the SLT had little influence on the cumulative As release or
PPLI values. Experimentally determined PPLI values were in agreement with
those from model estimations. A five-step SLT with an L/S of 10Lkg-1 at
each step, combined with a logarithmic function fitting was suggested for
the easy estimation of PPLI. Results of the sequential extraction
procedure showed that large portions of more labile As fractions
(non-specifically and specifically sorbed fractions) were removed during
long-term leaching and so were small, but non-negligible, portions of
strongly bound As fractions.
KW - Arsenic
KW - Excavated soils
KW - Pollution potential leaching index
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180308
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20170914
STAT- MEDLINE
DOCNO- medline/28837872

226 - TOXLINE
TI - Identification of C-terminal Regions in Arabidopsis thaliana Phytochelatin
Synthase 1 Specifically Involved in Activation by Arsenite.
AU - Uraguchi S
AD - Department of Public Health, School of Pharmacy, Kitasato University, 5-9-1
Shirokane, Minato-ku, Tokyo, 108-8641 Japan.
AU - Sone Y
AD - Department of Public Health, School of Pharmacy, Kitasato University, 5-9-1
Shirokane, Minato-ku, Tokyo, 108-8641 Japan.
AU - Ohta Y
AD - Department of Public Health, School of Pharmacy, Kitasato University, 5-9-1
Shirokane, Minato-ku, Tokyo, 108-8641 Japan.
AU - Ohkama-Ohtsu N
AD - Institute of Agriculture, Tokyo University of Agriculture and Technology, 3-
5-8 Saiwaicho, Fuchu, Tokyo, 183-8509 Japan.
AU - Hofmann C
AD - Department of Plant Physiology, University of Bayreuth, Universit�tsstrasse
30, D-95440 Bayreuth, Germany.
AU - Hess N
AD - Department of Plant Physiology, University of Bayreuth, Universit�tsstrasse
30, D-95440 Bayreuth, Germany.
AU - Nakamura R
AD - Department of Public Health, School of Pharmacy, Kitasato University, 5-9-1
Shirokane, Minato-ku, Tokyo, 108-8641 Japan.
AU - Takanezawa Y
AD - Department of Public Health, School of Pharmacy, Kitasato University, 5-9-1
Shirokane, Minato-ku, Tokyo, 108-8641 Japan.
AU - Clemens S
AD - Department of Plant Physiology, University of Bayreuth, Universit�tsstrasse
30, D-95440 Bayreuth, Germany.
AU - Kiyono M
AD - Department of Public Health, School of Pharmacy, Kitasato University, 5-9-1
Shirokane, Minato-ku, Tokyo, 108-8641 Japan.
SO - Plant Cell Physiol. 2018, Mar 01; 59(3):500-509. [Plant & cell physiology]
AB - Phytochelatins (PCs) are major chelators of toxic elements including
inorganic arsenic (As) in plant cells. Their synthesis confers tolerance
and influences within-plant mobility. Previous studies had shown that
various metal/metalloid ions differentially activate PC synthesis. Here we
identified C-terminal parts involved in arsenite- [As(III)] dependent
activation of AtPCS1, the primary Arabidopsis PC synthase. The T-DNA
insertion in the AtPCS1 mutant cad1-6 causes a truncation in the
C-terminal regulatory domain that differentially affects activation by
cadmium (Cd) and zinc (Zn). Comparisons of cad1-6 with the AtPCS1 null
mutant cad1-3 and the double mutant of tonoplast PC transporters abcc1/2
revealed As(III) hypersensitivity of cad1-6 equal to that of cad1-3. Both
cad1-6 and cad1-3 showed increased As distribution to shoots compared with
Col-0, whereas Zn accumulation in shoots was equally lower in cad1-6 and
cad1-3. Supporting these phenotypes of cad1-6, PC accumulation in the
As(III)-exposed plants were at trace level in both cad1-6 and cad1-3,
suggesting that the truncated AtPCS1 of cad1-6 is defective in PCS
activity in response to As(III). Analysis of a C-terminal deletion series
of AtPCS1 using the PCS-deficient mutant of fission yeast suggested
important regions within the C-terminal domain for As(III)-dependent PC
synthesis, which were different from the regions previously suggested for
Cd- or Zn-dependent activation. Interestingly, we identified a truncated
variant more strongly activated than the wild-type protein. This variant
could potentially be used as a tool to better restrict As mobility in
plants.
LA - eng
IS - 1471-9053 (Electronic)
PT - Journal Article
TA - Plant Cell Physiol
YR - 2018
DATE- 20180307
CITO- NLM
CS - Japan
FJT - Plant &amp; cell physiology
STAT- In-Process
DOCNO- medline/29281059

227 - TOXLINE
TI - Water and sediment quality assessment in the Colastin�-Corralito
stream system (Santa Fe, Argentina): impact of industry and agriculture on
aquatic ecosystems.
AU - Regaldo L
AD - Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET), 3000,
Santa Fe, Argentina. lregaldo@fhuc.unl.edu.ar.
AU - Gutierrez MF
AD - Facultad de Bioqu�mica y Ciencias Biol�gicas (FBCB), Universidad Nacional del
Litoral (UNL), 3000, Santa Fe, Argentina.
AU - Reno U
AD - Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET), 3000,
Santa Fe, Argentina.
AU - Fern�ndez V
AD - Laboratorio de Ecotoxicolog�a, Departamento de Ciencias Naturales, Facultad
de Humanidades y Ciencias (FHUC), Universidad Nacional del Litoral (UNL), 3000,
Santa Fe, Argentina.
AU - Gervasio S
AD - Instituto Nacional de Tecnolog�a (INTEC - CONICET - UNL), Parque Tecnol�gico
Litoral Centro, 3000, Santa Fe, Argentina.
AU - Repetti MR
AD - Facultad de Ingenier�a Qu�mica (FIQ), Universidad Nacional del Litoral (UNL),
3000, Santa Fe, Argentina.
AU - Gagneten AM
AD - Laboratorio de Ecotoxicolog�a, Departamento de Ciencias Naturales, Facultad
de Humanidades y Ciencias (FHUC), Universidad Nacional del Litoral (UNL), 3000,
Santa Fe, Argentina.
SO - Environ Sci Pollut Res Int. 2018, Mar; 25(7):6951-6968. [Environmental
science and pollution research international]
AB - The present study focuses on the evaluation of metal (chromium, copper,
and lead), arsenic, and pesticide (atrazine and endosulfan) contamination
in freshwater streams of one of the most important agricultural and
industrial areas of central-eastern Argentina, which has not been reported
earlier. The environmental fate of inorganic microcontaminants and
pesticides was assessed. Samples were collected monthly for a year.
Pesticide concentrations were measured in water; metal and arsenic
concentrations were measured in water and sediments, and physicochemical
variables were analyzed. In most cases, metals and arsenic in water
exceeded the established guideline levels for the protection of aquatic
biota: 98 and 56.25% of the samples showed higher levels of Cr and Pb,
while 81.25 and 85% of the samples presented higher values for Cu and As,
respectively. Cr, Pb, Cu, and As exceeded 181.5 times, 41.6 times, 57.5
times, and 12.9 times, respectively, the guideline level values. In
sediment samples, permitted levels were also surpassed by 40% for Pb, 15%
for As, 4% for Cu, and 2% for Cr. Geoaccumulation Index (Igeo)
demonstrated that most of the sediment samples were highly polluted by Cr
and Cu and very seriously polluted by Pb, which indicates progressive
deterioration of the sediment quality. Atrazine never exceeded them, but
27% of the 48 water samples contained total endosulfan that surpassed the
guidelines. The findings of this study suggest risk to the freshwater
biota over prolong periods and possible risk to humans if such type of
contaminated water is employed for recreation or human use. Improper
disposal of industrial effluents and agricultural runoffs need to be
controlled, and proper treatment should be done before disposal to avoid
further deterioration of the aquifers of this area.
KW - Aquatic system assessment
KW - Arsenic
KW - Environmental pollution
KW - Metals
KW - Pesticides
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180305
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171222
STAT- In-Process
CM - Cites: Chemosphere. 2005 Nov;61(6):817-26 (medline /15963551)
CM - Cites: Sci Total Environ. 2014 Aug 1;488-489:208-19 (medline /24836129)
CM - Cites: Sci Total Environ. 2016 Mar 15;547:114-124 (medline /26780136)
CM - Cites: Chemosphere. 2014 Jul;107:423-31 (medline /24548646)
CM - Cites: Bull Environ Contam Toxicol. 2004 Jul;73(1):190-6 (medline
/15386091)
CM - Cites: Sci Total Environ. 2017 Feb 15;580:936-945 (medline /27988183)
CM - Cites: Environ Pollut. 1992;76(3):201-10 (medline /15091984)
CM - Cites: Bull Environ Contam Toxicol. 2005 Oct;75(4):820-6 (medline
/16400566)
CM - Cites: Ecotoxicol Environ Saf. 2011 May;74(4):741-7 (medline /21074853)
CM - Cites: Environ Toxicol Chem. 2001 Jan;20(1):84-98 (medline /11351418)
CM - Cites: Biol Rev Camb Philos Soc. 2006 May;81(2):163-82 (medline /16336747)
CM - Cites: Sci Total Environ. 2008 Jun 15;396(1):79-85 (medline /18372005)
CM - Cites: Arch Environ Contam Toxicol. 2011 Apr;60(3):406-16 (medline
/20523975)
CM - Cites: J Environ Biol. 2014 Jul;35(4):689-97 (medline /25004754)
CM - Cites: Environ Pollut. 2017 Oct;229:771-779 (medline /28693752)
CM - Cites: Environ Monit Assess. 2016 Aug;188(8):458 (medline /27395359)
CM - Cites: Water Res. 2004 Jul;38(13):3017-22 (medline /15261539)
CM - Cites: Environ Toxicol Chem. 2013 Jan;32(1):10-1 (medline /23147529)
CM - Cites: Braz J Biol. 2004 Feb;64(1):103-16 (medline /15195369)
CM - Cites: Chemosphere. 2009 Feb;74(5):676-81 (medline /19042009)
CM - Cites: Environ Sci Technol. 2005 Apr 1;39(7):1921-31 (medline /15871220)
CM - Cites: J Environ Biol. 2009 Mar;30(2):213-6 (medline /20121020)
CM - Cites: Water Sci Technol. 2002;46(4-5):231-9 (medline /12361015)
CM - Cites: Environ Sci Technol. 2006 Dec 15;40(24):7570-6 (medline /17256496)
CM - Cites: Environ Int. 2001 Jun;26(7-8):483-95 (medline /11485216)
CM - Cites: Arch Environ Contam Toxicol. 1991 Feb;20(2):271-5 (medline
/2015003)
CM - Cites: Int J Environ Res Public Health. 2015 May 21;12(5):5465-82 (medline
/26006123)
CM - Cites: J Contam Hydrol. 2002 Jan;54(1-2):19-35 (medline /11848266)
CM - Cites: Sci Total Environ. 2017 Feb 15;580:699-709 (medline /27986319)
CM - Cites: Ecotoxicology. 2012 Jan;21(1):37-47 (medline /21842398)
CM - Cites: Chemosphere. 2013 Feb;90(6):1860-9 (medline /23177716)
DOCNO- medline/29273985

228 - TOXLINE
TI - Effects of acclimation on arsenic bioaccumulation and biotransformation in
freshwater medaka Oryzias mekongensis after chronic arsenic exposure.
AU - Chen L
AD - Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong
Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of
Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China; University of
Chinese Academy of Sciences, Beijing, 100049, China.
AU - Zhang W
AD - Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong
Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of
Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.
AU - Guo Z
AD - State Key Laboratory of Marine Resource Utilization in South China Sea,
College of Oceanology, Hainan University, Haikou, 570228, China.
AU - Zhang L
AD - Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong
Provincial Key Laboratory of Applied Marine Biology, South China Sea Institute of
Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China. Electronic
address: zhangli@scsio.ac.cn.
SO - Environ Pollut. 2018, Jul; 238:17-25. [Environmental pollution (Barking,
Essex : 1987)]
AB - Fish can acclimate to chronic arsenic (As) exposure, but the mechanisms of
acclimation remain unclear to date. Therefore, this study conducted 28-d
chronic inorganic As [As(III) and As(V)] exposures in freshwater medaka
(Oryzias mekongensis), examined the As bioaccumulation and
biotransformation during exposure, and the As acute toxicity and
toxicokinetics after exposure. After chronic As(V) exposure, the 96-h
lethal concentration (96-h LC50) of As(V) increased 1.3-fold (from 223 to
286&#8239;&mu;mol/L), indicating that the fish became more tolerant to
As(V). The As bioaccumulation in As(V)-exposed fish increased gradually
during the initial 21-d exposure period and then decreased at 28&#8239;d,
indicating that acclimation occurred to regulate the total As levels.
Toxicokinetics measurement suggested that As(V) uptake (uptake rate
constant, ku) was significantly decreased and As(III) elimination (efflux
rate constant, ke1) was significantly increased, both of which could
reduce As bioaccumulation. Furthermore, the organic As species became more
predominant (50.1-69.3%) in exposed fish, while the inorganic As species
were predominant (53.6-56.4%) in the control fish, suggesting that the
capability of As biotransformation increased to acclimate inorganic As
during chronic exposure. In summary, this study elucidated the acclimation
strategies (reduced bioaccumulation and increased biotransformation) of
O. mekongensis to counter the ambient As contamination.
KW - Acclimation
KW - Arsenic
KW - Bioaccumulation
KW - Biotransformation
KW - Freshwater fish
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180515
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180310
STAT- In-Process
DOCNO- medline/29533880

229 - TOXLINE
TI - Protective Effect of Hydroxytyrosol Against Oxidative Stress Mediated by
Arsenic-Induced Neurotoxicity in Rats.
AU - Soni M
AD - Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana,
124001, India.
AU - Prakash C
AD - Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana,
124001, India.
AU - Dabur R
AD - Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana,
124001, India.
AU - Kumar V
AD - Department of Biochemistry, Maharshi Dayanand University, Rohtak, Haryana,
124001, India. vksiwach.biochem@mdurohtak.ac.in.
SO - Appl Biochem Biotechnol. 2018, Mar 02. [Applied biochemistry and
biotechnology]
AB - The present study reports beneficial effect of hydroxytyrosol (HT) against
arsenic (As)-induced oxidative stress in the rat brain. Rats were orally
administered with sodium arsenite dissolved in distilled water
(25 ppm, by oral gavage) for 8 weeks or HT (10 mg/kg b.
wt.) in combination with As. Results showed increase in protein oxidation
and lipid peroxidation, while catalase and superoxide dismutase (SOD)
activities as well as GSH content were decreased after As exposure in rat
brain. Fourier transform infrared analysis showed significant alteration
in peak area values that also validated the oxidative damage to lipids and
proteins. In addition, As exposure caused increase in protein expression
of caspase-3 and Bax, while Bcl-2 expression was downregulated resulting
in translocation of cytochrome c from mitochondria to cytosol. Treatment
of HT with As reversed protein oxidation, lipid peroxidation, and
increased GSH content as well as catalase and SOD activities.
Administration of HT also prevented translocation of cytochrome c from
mitochondria and increased mitochondria/cytosol ratio of cytochrome c.
Hence, treatment of HT with As improved antioxidant system and efficiently
lowered the generation of oxidative stress in rat brain.
KW - Arsenic
KW - FTIR
KW - Hydroxytyrosol
KW - Neurotoxicity
KW - Oxidative stress
LA - eng
IS - 1559-0291 (Electronic)
PT - Journal Article
TA - Appl Biochem Biotechnol
YR - 2018
DATE- 20180302
CITO- NLM
CS - United States
FJT - Applied biochemistry and biotechnology
EDAT- 20180302
STAT- Publisher
DOCNO- medline/29497947

230 - TOXLINE
TI - Remediation of Arsenic contaminated soil using malposed intercropping of
Pteris vittata L. and maize.
AU - Ma J
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing 100101, PR China; Agro-Environmental Protection
Institute, Ministry of Agriculture, Tianjin 300191, PR China; College of Natural
Resources and Environment, South China Agricultural University, Guangzhou, 510642,
PR China.
AU - Lei E
AD - School of Life Sciences and Technology, Honghe University, 661100, PR China.
AU - Lei M
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing 100101, PR China. Electronic address:
leim@igsnrr.ac.cn.
AU - Liu Y
AD - School of Life Sciences and Technology, Honghe University, 661100, PR China.
AU - Chen T
AD - Institute of Geographic Sciences and Natural Resources Research, Chinese
Academy of Sciences, Beijing 100101, PR China.
SO - Chemosphere. 2018, Mar; 194:737-744. [Chemosphere]
AB - Intercropping of arsenic (As) hyperaccumulator and cash crops during
remediation of contaminated soil has been applied in farmland remediation
project. However, little is known about the fate of As fractions in the
soil profile and As uptake within the intercropping plants under field
condition. In this study, As removal, uptake, and translocation were
investigated within an intercropping system of Pteris vittata L.
(P. vittata) and maize (Zea mays). Results indicated that the
concentration of As associated with amorphous Fe (hydr)oxides in the
10-20 cm soil layer was significantly lower under malposed
intercropping of P. vittata and maize, and As accumulation in
P. vittata and biomass of P. vittata were simultaneously higher
under malposed intercropping than under coordinate intercropping, leading
to a 2.4 times higher rate of As removal. Although maize roots absorbed
over 13.4 mg kg-1 As and maize leaves and flowers accumulated
over 21.5 mg kg-1 As (translocation factor higher than 1),
grains produced in all intercropping modes accumulated lower levels of As,
satisfying the standard for human consumption. Our results suggested that
malposed intercropping of a hyperaccumulator and a low-accumulation cash
crop was an ideal planting pattern for As remediation in soil.
Furthermore, timely harvest of P. vittata, agronomic strategies
during remediation, and appropriate management of the above ground parts
of P. vittata and high-As tissues of cash crops may further improve
remediation efficiency.
KW - Arsenic fraction
KW - Intercropping
KW - Maize
KW - Pteris vittata L
KW - Remediation
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180228
CI - Copyright &copy; 2017. Published by Elsevier Ltd.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171122
STAT- MEDLINE
DOCNO- medline/29247933

231 - TOXLINE
TI - Effects of steaming on contaminants of emerging concern levels in seafood.
AU - Barbosa V
AD - Division of Aquaculture and Seafood Upgrading, Portuguese Institute for the
Sea and Atmosphere, I.P. (IPMA), Lisboa, Portugal; Interdisciplinary Centre of
Marine and Environmental Research (CIIMAR), Universidade do Porto, Porto, Portugal.
Electronic address: vera.barbosa@ipma.pt.
AU - Maulvault AL
AD - Division of Aquaculture and Seafood Upgrading, Portuguese Institute for the
Sea and Atmosphere, I.P. (IPMA), Lisboa, Portugal; MARE - Marine and Environmental
Sciences Centre, Faculty of Sciences, University of Lisbon (FCUL), Lisboa,
Portugal; Interdisciplinary Centre of Marine and Environmental Research (CIIMAR),
Universidade do Porto, Porto, Portugal. Electronic address: aluisa@ipma.pt.
AU - Alves RN
AD - Division of Aquaculture and Seafood Upgrading, Portuguese Institute for the
Sea and Atmosphere, I.P. (IPMA), Lisboa, Portugal. Electronic address:
ricardo.alves@ipma.pt.
AU - Kwadijk C
AD - IMARES, Wageningen Marine Research, AB Ijmuiden, The Netherlands. Electronic
address: christiaan.kwadijk@wur.nl.
AU - Kotterman M
AD - IMARES, Wageningen Marine Research, AB Ijmuiden, The Netherlands. Electronic
address: michiel.kotterman@wur.nl.
AU - Tediosi A
AD - Aeiforia Srl, Gariga di Podenzano (PC), Italy. Electronic address:
alice.tediosi@aeiforia.eu.
AU - Fern�ndez-Tejedor M
AD - Institute of Agriculture and Food Research &amp; Technology (IRTA), Sant
Carles de la R�pita, Tarragona, Spain. Electronic address:
margarita.fernandez@irta.cat.
AU - Sloth JJ
AD - National Food Institute, Technical University of Denmark, Kgs Lyngby,
Denmark. Electronic address: jjsl@food.dtu.dk.
AU - Granby K
AD - National Food Institute, Technical University of Denmark, Kgs Lyngby,
Denmark. Electronic address: kgra@food.dtu.dk.
AU - Rasmussen RR
AD - National Food Institute, Technical University of Denmark, Kgs Lyngby,
Denmark. Electronic address: riro@food.dtu.dk.
AU - Robbens J
AD - Institute for Agricultural and Fisheries Research (ILVO), Ostend, Belgium.
Electronic address: Johan.Robbens@ilvo.vlaanderen.be.
AU - De Witte B
AD - Institute for Agricultural and Fisheries Research (ILVO), Ostend, Belgium.
Electronic address: Bavo.Dewitte@ilvo.vlaanderen.be.
AU - Trabal�n L
AD - Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV,
Universitat Rovira i Virgili, Reus, Catalonia, Spain. Electronic address:
laura.trabalon@urv.cat.
AU - Fernandes JO
AD - LAQV-REQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy,
University of Porto, Porto, Portugal. Electronic address: josefer@ff.up.pt.
AU - Cunha SC
AD - LAQV-REQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy,
University of Porto, Porto, Portugal. Electronic address: sara.cunha@ff.up.pt.
AU - Marques A
AD - Division of Aquaculture and Seafood Upgrading, Portuguese Institute for the
Sea and Atmosphere, I.P. (IPMA), Lisboa, Portugal; Interdisciplinary Centre of
Marine and Environmental Research (CIIMAR), Universidade do Porto, Porto, Portugal.
Electronic address: amarques@ipma.pt.
SO - Food Chem Toxicol. 2018, May 19; 118:490-504. [Food and chemical
toxicology : an international journal published for the British Industrial
Biological Research Association]
AB - Seafood consumption is a major route for human exposure to environmental
contaminants of emerging concern (CeCs). However, toxicological
information about the presence of CeCs in seafood is still insufficient,
especially considering the effect of cooking procedures on contaminant
levels. This study is one among a few who evaluated the effect of steaming
on the levels of different CeCs (toxic elements, PFCs, PAHs, musk
fragrances and UV-filters) in commercially relevant seafood in Europe, and
estimate the potential risks associated with its consumption for
consumers. In most cases, an increase in contaminant levels was observed
after steaming, though varying according to contaminant and seafood
species (e.g. iAs, perfluorobutanoate, dibenzo(ah)anthracene in Mytilus
edulis, HHCB-Lactone in Solea sp., 2-Ethylhexyl salicylate in Lophius
piscatorius). Furthermore, the increase in some CeCs, like Pb, MeHg, iAs,
Cd and carcinogenic PAHs, in seafood after steaming reveals that adverse
health effects can never be excluded, regardless contaminants
concentration. However, the risk of adverse effects can vary. The drastic
changes induced by steaming suggest that the effect of cooking should be
integrated in food risk assessment, as well as accounted in CeCs
regulations and recommendations issued by food safety authorities, in
order to avoid over/underestimation of risks for consumer health.
KW - 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(g)-2-benzopyran
KW - 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-(g)-2-benzopyran-1-one
KW - 2,2-Dihydroxy-4,4-dimethoxybenzophenone
KW - 2-Ethylhexyl salicylate
KW - 3,3,5-Trimethylcyclohexylsalicylate
KW - 3-(4-Methylbenzylidene)camphor
KW - 4-MBC
KW - 6,7-dihydro-1,1,2,3,3-pentamethyl-4(5H)-indanone
KW - 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene
KW - AHTN
KW - ANOVA
KW - AsV
KW - BMDL
KW - BP1
KW - BaP
KW - Benzophenone 1
KW - Cd
KW - CeCs
KW - Cr
KW - Cu -copper
KW - DBENZO
KW - DHA
KW - DHMB
KW - DORM-4
KW - DPMI
KW - EC
KW - ECHA
KW - EFSA
KW - EHS
KW - EPA
KW - ERM-BC211
KW - European Food Safety Authority
KW - European chemicals agency
KW - European commission
KW - GC-MS
KW - GC–IT-MS/MS
KW - HBGVs
KW - HHCB
KW - HHCB-lactone
KW - HPLC
KW - HS
KW - Hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate
KW - Hg
KW - ICP-MS
KW - ISTD
KW - Kow
KW - LOD
KW - LOQ
KW - MOE
KW - MS- mass spectrometry
KW - MeHg
KW - Musk fragrances and UV-Filters
KW - NOAEL
KW - OC
KW - Octocrylene
KW - PAH2
KW - PAH4
KW - PAH8
KW - PAHs
KW - PCBs
KW - PCPs
KW - PFBA
KW - PFBS
KW - PFCs
KW - PFDS
KW - PFDcA
KW - PFDoA
KW - PFHpA
KW - PFHpS
KW - PFHxA
KW - PFHxS
KW - PFNA
KW - PFOA
KW - PFOS
KW - PFPeA
KW - PFTeA
KW - PFTrA
KW - PFUnA
KW - POPs
KW - Pb
KW - QuEChERS
KW - RSD
KW - Seafood
KW - Steaming
KW - Sum of benzo(a)anthracene
KW - TAs
KW - TDI
KW - THg
KW - TORT-2
KW - TWI
KW - Toxic elements
KW - UF
KW - UL
KW - analysis of variance
KW - arsenic V
KW - benchmark dose lower limit
KW - benz(a)anthracene
KW - benzo(a)pyrene
KW - benzo(b)fluoranthene
KW - benzo(ghi)perylene
KW - benzo(k)fluoranthene
KW - cadmium
KW - chromium
KW - chrysene
KW - contaminants of emerging concern
KW - dSPE
KW - dibenzo(a,h)anthracene
KW - dispersive solid-phase extraction
KW - docosahexaenoic acid
KW - dogfish muscle reference material
KW - easy
KW - effective
KW - eicosapentaenoic aci
KW - gas chromatography-ion trap-tandem mass spectrometr
KW - gas chromatography-mass spectrometry
KW - health-based guidance values
KW - high performance liquid chromatography
KW - iAs
KW - indeno(123cd)pyrene
KW - inductively coupled plasma mass spectrometer
KW - inorganic arsenic
KW - internal standards
KW - lead
KW - limit of detection
KW - limit of quantification
KW - liquid-chromatography-ion trap tandem mass spectrometry
KW - lobster hepatopancreas reference material
KW - margins of exposure
KW - mercury
KW - methyl mercury
KW - n-octanol/water partition coefficientLC-IT-MS/MS
KW - no observed adverse effect level
KW - perfluorinated compounds
KW - perfluorobutane sulfonate
KW - perfluorobutanoate
KW - perfluoroctanoate
KW - perfluorodecane sulfonate
KW - perfluorodecanoate
KW - perfluorododecanoate
KW - perfluoroheptane sulfonate
KW - perfluoroheptanoate
KW - perfluorohexane sulfonate
KW - perfluorohexanoate
KW - perfluorononanoate
KW - perfluorooctane sulfonate
KW - perfluoropentanoate
KW - perfluorotetradecanoate
KW - perfluorotridecanoate
KW - perfluorundecanoate
KW - persistent organic pollutants
KW - personal care products
KW - polychlorinated biphenyls
KW - polycyclic aromatic hydrocarbons
KW - quick
KW - relative standard deviation
KW - rice reference material
KW - rugged and safe
KW - safety/uncertainty factor
KW - sum of benzo(a)pyrene
KW - tolerable daily intake
KW - tolerable upper intake level
KW - tolerable weekly intake
KW - total arsenic
KW - total mercury
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180519
STAT- Publisher
DOCNO- medline/29787848

232 - TOXLINE
TI - Complex role of titanium dioxide nanoparticles in the trophic transfer of
arsenic from Nannochloropsis maritima to Artemia salina nauplii.
AU - Yang F
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of
Chinese Academy of Sciences, Beijing 100049, China.
AU - Zeng L
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China; University of
Chinese Academy of Sciences, Beijing 100049, China.
AU - Luo Z
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China.
AU - Wang Z
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China.
AU - Huang F
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China.
AU - Wang Q
AD - College of Chemistry and Chemical Engineering, Xiamen University, Xiamen
361005, China.
AU - Drobne D
AD - Biotechnical Faculty, Department of Biology, University of Ljubljana,
Ljubljana SI-1000, Slovenia.
AU - Yan C
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen 361021, China. Electronic address:
czyan@iue.ac.cn.
SO - Aquat Toxicol. 2018, May; 198:231-239. [Aquatic toxicology (Amsterdam,
Netherlands)]
AB - Increasing concern has been focused on the potential risks associated with
the trophic transfer to aquatic organisms of ambient contaminants in the
presence of titanium dioxide nanoparticles (nano-TiO2). This study
investigated the influence of nano-TiO2 on the trophic transfer of arsenic
(As) from the microalgae Nannochloropsis maritima to the brine shrimp
Artemia salina nauplii. We found that nano-TiO2 could significantly
facilitate As sorption on N. maritima within an exposure period of
24&#8239;h, and this sorption subsequently led to higher As trophic
transfer from the algae to A. salina according to trophic transfer factors
(TTFAs+nano-TiO2&#8239; > &#8239;TTFAs). However, after 48&#8239;h of
depuration, the retention of As in A. salina fed As-nano-TiO2-contaminated
algae was even lower than that in A. salina fed As-contaminated algae at
the same exposure concentrations. This result indicates that the increased
food chain transfer of As in the presence of nano-TiO2 can be explained by
adsorption of As onto nano-TiO2 in contaminated food (algae), but the
bioavailability of As in A. salina is reduced after the introduction of
nanoparticles. Although the stress enzyme activities of superoxide
dismutase (SOD) and acetylcholinesterase (AChE) in A. salina at a lower As
concentration treatment in the presence of nano-TiO2 were not
significantly changed, they increased with higher exposure concentrations
of As with or without nano-TiO2. Our study highlighted the complex role of
nanomaterials in the transfer of ambient contaminants via trophic chains
and the potential of nano-TiO2 to reduce the bioavailability of As via
trophic transfer to saltwater zooplankton.
KW - Arsenate
KW - Bioavailability
KW - Biochemical response
KW - Depuration
KW - Subcellular distribution
RN - 15FIX9V2JP
RN - D1JT611TNE
RN - EC 1.11.1.6
RN - EC 1.15.1.1
RN - EC 3.1.1.7
RN - N712M78A8G
LA - eng
IS - 1879-1514 (Electronic)
PT - Journal Article
TA - Aquat Toxicol
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Aquatic toxicology (Amsterdam, Netherlands)
EDAT- 20180310
STAT- MEDLINE
DOCNO- medline/29558708

233 - TOXLINE
TI - Synthesis of mesoporous bismuth-impregnated aluminum oxide for arsenic
removal: Adsorption mechanism study and application to a lab-scale column.
AU - Zhu N
AD - Institute of Soil Science, Chinese Academy of Sciences, No. 71 East Beijing
Road, Nanjing 210008, China; College of Resource and Environment, University of
Chinese Academy of Sciences, Beijing 100049, China.
AU - Qiao J
AD - Institute of Soil Science, Chinese Academy of Sciences, No. 71 East Beijing
Road, Nanjing 210008, China.
AU - Ye Y
AD - College of Education, Zhejiang University, Hangzhou 310007, China.
AU - Yan T
AD - Institute of Soil Science, Chinese Academy of Sciences, No. 71 East Beijing
Road, Nanjing 210008, China. Electronic address: tmyan@issas.ac.cn.
SO - J Environ Manage. 2018, Apr 01; 211:73-82. [Journal of environmental
management]
AB - High mobility and toxicity of arsenic [As (III)] limit its removal from an
aquatic environment and pose a threat to human health. In this work, batch
adsorption experiments were conducted to investigate the adsorption
capacity of bismuth-impregnated aluminum oxide (BiAl). Continuous
application of As (III) removal was achieved via a lab-scale column
reactor. Bismuth impregnation decreased the specific surface area of
aluminum oxide and affected its pore size distribution. However, because
of its abundant and well-proportioned mesoporous character, it also
enhanced its adsorption capacity through the surface complexation of As
(III). Batch adsorption experiments demonstrated a suitable Freundlich
model and a fitted pseudo-second-kinetic model for As (III) adsorption.
The main mechanism was chemisorption with both bismuth and aluminum atoms;
however, physisorption also contributed to arsenic adsorption at the
initial stage of the reaction. The Adams-Bohart model better described the
breakthrough curves than the Thomas model. BiAl exhibited efficient As
(III) adsorption over a wide pH range and could be applied to As (III)
removal from wastewater. A high As (III) removal efficiency (91.6%) was
obtained at an initial As (III) concentration of 5&#8239;mg&#8239;L-1 at a
flow rate of 1&#8239;mL min-1. This study indicates the potential for the
practical application of BiAl in As (III) removal.
KW - Adsorption mechanism
KW - Aluminum oxide
KW - Arsenic removal
KW - Bismuth
KW - Impregnation
KW - Practical application
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180217
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180202
STAT- In-Process
DOCNO- medline/29408085

234 - TOXLINE
TI - Arsenic distribution in a pasture area impacted by past mining activities.
AU - Abad-Valle P
AD - Department of Environmental Geochemistry, IRNASA (CSIC), C/ Cordel de Merinas
40-52, 37008 Salamanca, Spain.
AU - �lvarez-Ayuso E
AD - Department of Environmental Geochemistry, IRNASA (CSIC), C/ Cordel de Merinas
40-52, 37008 Salamanca, Spain. Electronic address: esther.alvarez@irnasa.csic.es.
AU - Murciego A
AD - Department of Geology, Salamanca University, Plza. de los Ca�dos s/n, 37008
Salamanca, Spain.
AU - Mu�oz-Centeno LM
AD - Department of Botany, Salamanca University, Avda. Ldo. M�ndez Nieto s/n,
37007 Salamanca, Spain.
AU - Alonso-Rojo P
AD - Department of Edaphology, Salamanca University, Avda. Filiberto Villalobos
117, 37007 Salamanca, Spain.
AU - Villar-Alonso P
AD - Saloro SLU, Avda. Italia 8, 37006 Salamanca, Spain.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:228-237. [Ecotoxicology and
environmental safety]
AB - Former mine exploitations entail a serious threat to surrounding
ecosystems as after closure of mining activities their unmanaged wastes
can be a continuous source of toxic trace elements. Quite often these mine
sites are found within agricultural farming areas, involving serious
hazards as regards product (feed/food) quality. In this work a grazing
land impacted by the abandoned mine exploitation of an arsenical deposit
was studied so as to evaluate the fate of arsenic (As) and other trace
elements and the potential risks involved. With this aim, profile soil
samples (0-50cm) and pasture plant species (Agrostis truncatula, Holcus
annus and Leontodon longirostris) were collected at different distances
(0-100m) from the mine waste dump and analyzed for their trace element
content and distribution. Likewise, plant trace element accumulation from
impacted grazing soils and plant trace element translocation were
assessed. The exposure of livestock grazing animals to As was also
evaluated, establishing its acceptability regarding food safety and animal
health. International soil guideline values for As in grazing land soils
(50mgkg-1) resulted greatly exceeded (up to about 20-fold) in the studied
mining-affected soils. Moreover, As showed a high mobilization potential
under circumstances such as phosphate application or establishment of
reducing conditions. Arsenic exhibited relatively high translocation
factor (TF) values (up to 0.32-0.89) in pasture plant species, reaching
unsafe concentrations in their above-ground tissues (up to 32.9, 16.9 and
9.0mgkg-1 in Agrostis truncatula, Leontodon longirostris and Holcus annus,
respectively). Such concentrations represent an elevated risk of As
transfer to the high trophic-chain levels as established by international
legislation. The limited fraction of arsenite found in plant roots should
play an important role in the relatively high As root-to-shoot
translocation shown by these plant species. Both soil ingestion and
pasture intake resulted important entrance pathways of As into livestock
animals, showing quite close contribution levels. The cow acceptable daily
intake (ADI) of As regarding food safety was surpassed in some locations
of the study area when the species Agrostis truncatula was considered as
the only pasture feed. Restrictions in the grazing use of lands with
considerable As contents where this plant was the predominant pasture
species should be established in order to preserve food quality.
Therefore, the exposure of livestock animals to As via both soil ingestion
and pasture consumption should be taken into account to establish the
suitability of mining-impacted areas for gazing.
KW - Arsenic
KW - Grazing land
KW - Phytoavailability
KW - Risk assessment
KW - Soil pollution
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180314
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20170914
STAT- MEDLINE
DOCNO- medline/28846927
235 - TOXLINE
TI - Regulation of oxidative stress and mineral nutrient status by selenium in
arsenic treated crop plant Oryza sativa.
AU - Singh R
AD - Department of Environmental Science, BBAU, Lucknow, India.
AU - Upadhyay AK
AD - Department of Environmental Science, BBAU, Lucknow, India. Electronic
address: upadhyay.eb@rediffmail.com.
AU - Singh DP
AD - Department of Environmental Science, BBAU, Lucknow, India. Electronic
address: dpsinghbbau@gmail.com.
SO - Ecotoxicol Environ Saf. 2018, Feb; 148:105-113. [Ecotoxicology and
environmental safety]
AB - The present study was conducted to examine the impact of selenium (Se) on
mineral nutrient status and oxidative stress in crop plant Oryza sativa
treated with arsenic (As). Scanning electron microscopy (SEM) coupled with
Energy dispersive x-ray spectroscopy (EDS) study revealed the
morphological deformities in leaf veins along with granular deposition on
the leaf surface. The EDS analysis exhibited loss of elements (S, Si, Cl,
K, Ca, Fe and Cu) in As(III) treatment in rice roots as compared to
untreated root. In the case of As(III) treated shoot, changes in elements
content in term of percent atomic weight was K (1.17-0.90%), Cl
(1.04-24.75%), Na (0.65-3.52%) and S (0.49-2.52%) when compared with
untreated shoot. The result of EDS analysis showed that As limits the
concentration of important mineral elements present in the rice root and
shoot. Rice plant treated with Se (10&micro;M) and sub lethal dose of
As(III) (60&micro;M) showed better growth responses in term of root, shoot
length (11.4% and 10.71%, respectively), biomass (11.7%), reduced
malonyldialdehyde content (35.14%) and stimulated antioxidant level
indicating better As tolerance potential against As. Further, a selenium
dependent significant reduction in As accumulation was also observed in
root (14.24%) and shoot (23.78%) of rice plant when compared with plant
treated with As alone. This study highlights the potential of Se to
ameliorate the ecotoxicological risks associated with the As buildup in
agricultural land.
KW - Antioxidants enzyme
KW - Arsenite (III)
KW - Mineral nutrient
KW - Rice
KW - Selenium
RN - 4Y8F71G49Q
RN - H6241UJ22B
RN - N5509X556J
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180515
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171106
STAT- MEDLINE
DOCNO- medline/29035752

236 - TOXLINE
TI - Soil properties influence kinetics of soil acid phosphatase in response to
arsenic toxicity.
AU - Wang Z
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, 712100 Shaanxi, China.
AU - Tan X
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, 712100 Shaanxi, China.
AU - Lu G
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, 712100 Shaanxi, China.
AU - Liu Y
AD - Global Centre for Environmental Research, The Faculty of Science and
Information Technology, University of Newcastle, University Drive, Callaghan, NSW
2308, Australia; Cooperative Research Centre for Contamination Assessment and
Remediation of the Environment (CRC CARE), Mawson Lakes, SA 5095, Australia.
AU - Naidu R
AD - Global Centre for Environmental Research, The Faculty of Science and
Information Technology, University of Newcastle, University Drive, Callaghan, NSW
2308, Australia; Cooperative Research Centre for Contamination Assessment and
Remediation of the Environment (CRC CARE), Mawson Lakes, SA 5095, Australia.
AU - He W
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling, 712100 Shaanxi, China. Electronic address:
wenxiang.he@nwafu.edu.cn.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:266-274. [Ecotoxicology and
environmental safety]
AB - Soil phosphatase, which plays an important role in phosphorus cycling, is
strongly inhibited by Arsenic (As). However, the inhibition mechanism in
kinetics is not adequately investigated. In this study, we investigated
the kinetic characteristics of soil acid phosphatase (ACP) in 14 soils
with varied properties, and also explored how kinetic properties of soil
ACP changed with different spiked As concentrations. The results showed
that the Michaelis constant (Km) and maximum reaction velocity (Vmax)
values of soil ACP ranged from 1.18 to 3.77mM and 0.025-0.133mMh-1 in
uncontaminated soils. The kinetic parameters of soil ACP in different
soils changed differently with As contamination. The Km remained unchanged
and Vmax decreased with increase of As concentration in most acid and
neutral soils, indicating a noncompetitive inhibition mechanism. However,
in alkaline soils, the Km increased linearly and Vmax decreased with
increase of As concentration, indicating a mixed inhibition mechanism that
include competitive and noncompetitive. The competitive inhibition
constant (Kic) and noncompetitive inhibition constant (Kiu) varied among
soils and ranged from 0.38 to 3.65mM and 0.84-7.43mM respectively. The
inhibitory effect of As on soil ACP was mostly affected by soil organic
matter and cation exchange capacity. Those factors influenced the
combination of As with enzyme, which resulted in a difference of As
toxicity to soil ACP. Catalytic efficiency (Vmax/Km) of soil ACP was a
sensitive kinetic parameter to assess the ecological risks of soil As
contamination.
KW - Arsenic
KW - Inhibition constant
KW - Noncompetitive inhibition
KW - Soil acid phosphatase
KW - Soil property
RN - 27YLU75U4W
RN - EC 3.1.3.2
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180314
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20170914
STAT- MEDLINE
DOCNO- medline/28850809

237 - TOXLINE
TI - Toxicological Aspect of Some Selected Medicinal Plant Samples Collected
from Djelfa, Algeria Region.
AU - Begaa S
AD - Neutron Activation Analysis Department NAA, Nuclear Research Centre of
Birine, Po Box 180, Ain Oussera, 17200, Djelfa, Algeria. samirbegaa@yahoo.fr.
AU - Messaoudi M
AD - Neutron Activation Analysis Department NAA, Nuclear Research Centre of
Birine, Po Box 180, Ain Oussera, 17200, Djelfa, Algeria.
SO - Biol Trace Elem Res. 2018, May 10. [Biological trace element research]
AB - Instrumental neutron activation analysis (INAA) has been used to determine
the concentration of some toxic chemical elements in a variety of aromatic
plants samples collected from Djelfa region. In the present work, eight
medicinal plants were examined, such as Artemisia herba-alba Asso.,
Artemisia compestris L., Laurus nobilis L., Origanum vulgare L., Mentha
spicata L., Rosmarinus officinalis L., Mentha pulegium L., and Pistacia
lentiscus L. The levels of toxic elements were compared to their daily
total intake; Arsenic was present in all plant species examined, with a
concentration ranging from 0.18 to 5.44 &mu;g g-&thinsp;1.
Bromine was also detected in all the medicinal plant species, with high
concentrations, compared to arsenic except in the case of Laurus nobilis
that has the highest concentration of arsenic. Cerium, cobalt, chromium,
and antimony were presented in all plant species. The exactitude of the
results was assessed by analyzing the certified reference material of
SRM-NIST 1573a and CRM GB07605 (GSV4). These data analysis for this
medicinal plant can be useful for therapeutics and pharmaceutical
purposes.
KW - Antimony
KW - Arsenic
KW - Bromine
KW - Daily total intake
KW - INAA method
KW - Medicinal plants
KW - Toxic elements
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180511
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180510
STAT- Publisher
DOCNO- medline/29748929

238 - TOXLINE
TI - Concentrations of Trace Elements and Clinical Outcomes in Hemodialysis
Patients: A Prospective Cohort Study.
AU - Tonelli M
AD - Departments of Medicine and tonelli.admin@ucalgary.ca.
AU - Wiebe N
AD - Departments of Medicine and.
AU - Bello A
AD - Departments of Medicine and.
AU - Field CJ
AD - Agricultural, Food &amp; Nutritional Science, University of Alberta,
Edmonton, Canada.
AU - Gill JS
AD - Departments of Medicine and.
AU - Hemmelgarn BR
AD - Departments of Medicine and.
AU - Holmes DT
AD - Pathology and Laboratory Medicine, University of British Columbia, Vancouver,
Canada; and.
AU - Jindal K
AD - Departments of Medicine and.
AU - Klarenbach SW
AD - Departments of Medicine and.
AU - Manns BJ
AD - Departments of Medicine and.
AU - Thadhani R
AD - Division of Nephrology, Massachusetts General Hospital, Boston,
Massachusetts.
AU - Kinniburgh D
AD - Physiology and Pharmacology, University of Calgary, Calgary, Canada.
AU - Alberta Kidney Disease Network
AD - Physiology and Pharmacology, University of Calgary, Calgary, Canada.
SO - Clin J Am Soc Nephrol. 2018, Jun 07; 13(6):907-915. [Clinical journal of
the American Society of Nephrology : CJASN]
AB - BACKGROUND AND OBJECTIVES: Deficiency of essential trace elements and
excess of potentially toxic trace elements are common in patients on
hemodialysis. Whether these abnormalities are associated with poor
outcomes is unknown but worth investigating, because they are potentially
treatable.
AB - DESIGN, SETTING, PARTICIPANTS, &amp; MEASUREMENTS: We did a prospective
longitudinal study of 1278 patients on incident hemodialysis, assessing
blood concentrations of 25 trace elements at baseline. We used adjusted
logistic regression to evaluate the association between trace element
status and four outcomes (death, cardiovascular events, systemic
infection, and hospitalization). A priori hypotheses concerned (1)
deficiency of zinc, selenium, and manganese and (2) excess of lead,
arsenic, and mercury. Concentrations of the other 19 elements were tested
in hypothesis-generating analyses.
AB - RESULTS: Over 2 years of follow-up, 260 (20%) patients died, 285 (24%)
experienced a cardiovascular event, 117 (10%) were hospitalized for
systemic infection, and 928 (77%) were hospitalized for any cause. Lower
concentrations of zinc or manganese and higher concentrations of lead,
arsenic, or mercury were not independently associated with higher risk of
clinical outcomes. Lower concentrations of selenium were strongly and
independently associated with death (odds ratio, 0.86 per decile; 99.2%
confidence interval, 0.80 to 0.93) and all-cause hospitalization (odds
ratio, 0.92 per decile; 99.2% confidence interval, 0.86 to 0.98). In
exploratory analyses, higher copper concentrations were significantly
associated with higher risk of death (odds ratio, 1.07 per decile; 99.2%
confidence interval, 1.00 to 1.15), and cadmium levels in the highest
decile were associated with higher risk of death (odds ratio, 1.89; 99.2%
confidence interval, 1.06 to 3.38).
AB - CONCLUSIONS: Lower levels of zinc or manganese and higher concentrations
of lead, arsenic, or mercury were not associated with higher risk of
clinical outcomes, but lower concentrations of selenium were strongly and
independently associated with the risks of death and hospitalization.
KW - Arsenic
KW - Cadmium
KW - Copper
KW - Follow-up Studies
KW - Humans
KW - Ions
KW - Lead
KW - Logistic Models
KW - Longitudinal Studies
KW - Manganese
KW - Mercury
KW - Prospective Studies
KW - Selenium
KW - Trace Elements
KW - Zinc
KW - hemodialysis
KW - hospitalization
KW - renal dialysis
LA - eng
IS - 1555-905X (Electronic)
PT - Journal Article
TA - Clin J Am Soc Nephrol
YR - 2018
DATE- 20180617
CI - Copyright &copy; 2018 by the American Society of Nephrology.
CITO- NLM
CS - United States
FJT - Clinical journal of the American Society of Nephrology : CJASN
EDAT- 20180329
STAT- In-Data-Review
CM - Cites: BMC Nephrol. 2015 Apr 11;16:52 (medline /25884981)
CM - Cites: Int Urol Nephrol. 2014 Apr;46(4):809-15 (medline /24633699)
CM - Cites: Ann Ist Super Sanita. 2005;41(2):181-7 (medline /16244391)
CM - Cites: Ciba Found Symp. 1992;169:123-35; discussion 135-41 (medline
/1490419)
CM - Cites: J Renal Inj Prev. 2016 May 30;5(4):179-82 (medline /27689119)
CM - Cites: Nutrients. 2013 Jan 31;5(2):340-58 (medline /23434902)
CM - Cites: Nephrol Dial Transplant. 1996;11 Suppl 2:92-7 (medline /8804004)
CM - Cites: Br J Nutr. 2012 Jan;107(1):7-19 (medline /21767446)
CM - Cites: Semin Dial. 2010 Jul-Aug;23(4):389-95 (medline /20557491)
CM - Cites: Am J Kidney Dis. 2017 Nov;70(5):696-704 (medline /28838766)
CM - Cites: Am J Med. 2011 Apr;124(4):350-8 (medline /21435426)
CM - Cites: N Engl J Med. 1987 Jul 9;317(2):80-4 (medline /3587329)
CM - Cites: Met Ions Life Sci. 2013;13:499-534 (medline /24470102)
CM - Cites: Int Urol Nephrol. 2013 Jun;45(3):839-45 (medline /22684797)
CM - Cites: BMC Med. 2009 May 19;7:25 (medline /19454005)
CM - Cites: J Nephrol. 2013 Mar-Apr;26(2):266-72 (medline /23023721)
CM - Cites: Am J Clin Nutr. 1979 Oct;32(10):2076-85 (medline /114045)
CM - Cites: Sci Total Environ. 1990 Jun;95:89-105 (medline /2402627)
CM - Cites: Forensic Sci Int. 2005 Oct 4;153(1):39-44 (medline /15979835)
CM - Cites: Nephrol Dial Transplant. 2013 Mar;28(3):716-23 (medline /22764197)
CM - Cites: BMC Nephrol. 2011 Feb 16;12:10 (medline /21324196)
CM - Cites: Blood Purif. 1999;17(4):187-98 (medline /10494021)
CM - Cites: Nephrol Dial Transplant. 2011 Oct;26(10):3331-8 (medline /21372251)
CM - Cites: Annu Rev Med. 1978;29:93-8 (medline /348053)
CM - Cites: J Anal Toxicol. 2013 Sep;37(7):401-5 (medline /23794607)
CM - Cites: Crit Rev Clin Lab Sci. 1989;27(1):59-107 (medline /2647415)
CM - Cites: Lancet. 2007 Oct 20;370(9596):1453-7 (medline /18064739)
CM - Cites: BMC Med Inform Decis Mak. 2015 Apr 17;15:31 (medline /25886580)
CM - Cites: Lancet. 2000 Jul 15;356(9225):233-41 (medline /10963212)
CM - Cites: Blood Purif. 1998;16(5):253-60 (medline /9917533)
CM - Cites: N Engl J Med. 1976 Jan 22;294(4):184-8 (medline /1244532)
CM - Cites: Clin Nutr. 2012 Oct;31(5):630-6 (medline /22405403)
CM - Cites: Can J Diet Pract Res. 2005 Summer;66(2):98-102 (medline /15975198)
DOCNO- medline/29599300

239 - TOXLINE
TI - Protective Effect of Azadirachta indica and Vitamin E Against Arsenic
Acid-Induced Genotoxicity and Apoptosis in Rats.
AU - Oyagbemi AA
AD - a Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary
Medicine , University of Ibadan , Ibadan , Nigeria.
AU - Omobowale TO
AD - b Department of Veterinary Medicine, Faculty of Veterinary Medicine ,
University of Ibadan , Ibadan , Nigeria.
AU - Ola-Davies OE
AD - a Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary
Medicine , University of Ibadan , Ibadan , Nigeria.
AU - Adejumobi OA
AD - b Department of Veterinary Medicine, Faculty of Veterinary Medicine ,
University of Ibadan , Ibadan , Nigeria.
AU - Asenuga ER
AD - c Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary
Medicine , University of Benin , Benin City , Nigeria.
AU - Adeniji FK
AD - a Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary
Medicine , University of Ibadan , Ibadan , Nigeria.
AU - Adedapo AA
AD - d Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary
Medicine , University of Ibadan , Ibadan , Nigeria.
AU - Yakubu MA
AD - e Department of Environmental &amp; Interdisciplinary Sciences, College of
Science, Engineering &amp; Technology , NSB303, Vascular Biology Unit, Center for
Cardiovascular Diseases, COPHS, Texas Southern University , Houston , TX , USA.
SO - J Diet Suppl. 2018, May 04; 15(3):251-268. [Journal of dietary
supplements]
AB - Sodium arsenite (NaAsO2) is one of the major environmental toxicants with
severe toxicological consequences in some developing and developed
countries. Rats in Group A received normal saline. Genotoxicity and
apoptosis were induced by single intraperitoneal injection of 10 mg/kg
sodium arsenite to rats in Groups B-F. Rats in Groups C and D had earlier
been pretreated with Azadirachta indica (100 and 200 mg/kg) or E and F
with vitamin E (50 and 100 mg/kg), respectively. Markers of oxidative
stress, inflammation, hepatic damage, genotoxicity, and apoptosis were
assessed. Pretreatment of rats with either Azadirachta indica or vitamin E
led to a significant (p < .05) increase in the activities of
glutathione-S-transferase (GST), catalase (CAT), superoxide dismutase
(SOD), and reduced glutathione (GSH) in the liver compared to the group
that received NaAsO2 alone. Markers of oxidative stress and inflammation,
malondialdehyde (MDA), hydrogen peroxide (H2O2) generation, nitric oxide
(NO), and myeloperoxidase (MPO), were significantly (p < .05) lowered in
rats pretreated with Azadirachta indica or vitamin E. The frequency of
micronucleated polychromatic erythrocytes (MNPCEs) and expression of
caspase-3 were significantly (p < .05) reduced in rats pretreated with
either Azadirachta indica or vitamin E compared to rats intoxicated with
arsenite. Histopathology of the liver showed areas of infiltration of
inflammatory cells with deaths of numerous hepatocytes in
NaAsO2-intoxicated rats, and these were reversed by Azadirachta indica.
Together, we report for the first time the genoprotective and
antiapoptotic effect of Azadirachta indica by a significant reduction in
the frequency of micronuclei-induced apoptosis and oxidative stress by
arsenic intoxication.
KW - apoptosis
KW - chemoprevention
KW - genotoxicity
KW - liver
KW - sodium arsenite
LA - eng
IS - 1939-022X (Electronic)
PT - Journal Article
TA - J Diet Suppl
YR - 2018
DATE- 20180209
CITO- NLM
CS - England
FJT - Journal of dietary supplements
EDAT- 20170804
STAT- In-Process
DOCNO- medline/28777671

240 - TOXLINE
TI - Suppression of the release of arsenic from arsenopyrite by
carrier-microencapsulation using Ti-catechol complex.
AU - Park I
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Graduate School of Engineering, Hokkaido
University, Japan. Electronic address: ihp2035@gmail.com.
AU - Tabelin CB
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University,
Japan.
AU - Magaribuchi K
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Graduate School of Engineering, Hokkaido
University, Japan.
AU - Seno K
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Graduate School of Engineering, Hokkaido
University, Japan.
AU - Ito M
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University,
Japan.
AU - Hiroyoshi N
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University,
Japan.
SO - J Hazard Mater. 2018, Feb 15; 344:322-332. [Journal of hazardous
materials]
AB - Arsenopyrite is the most common arsenic-bearing sulfide mineral in nature,
and its weathering contributes to acid mine drainage (AMD) formation and
the release of toxic arsenic (As). To mitigate this problem,
carrier-microencapsulation (CME) using titanium (Ti)-catechol complex
(i.e., Ti-based CME) was investigated to passivate arsenopyrite by forming
a protective coating. Ti4+ ion dissolved in sulfuric acid and catechol
were used to successfully synthesize Ti(IV) tris-catecholate complex,
[Ti(Cat)3]2-, which was stable in the pH range of 5-12. Electrochemical
studies on the redox properties of this complex indicate that its
oxidative decomposition was a one-step, irreversible process. The leaching
of As from arsenopyrite was suppressed by CME treatment using the
synthesized Ti-catechol complex. Scanning electron microscopy with energy
dispersive X-ray spectroscopy (SEM-EDX) and diffuse reflectance infrared
Fourier transform spectroscopy (DRIFTS) indicate that this suppression was
primarily due to the formation of an anatase (&beta;-TiO2)-containing
coating. Based on these results, a detailed 4-step mechanism to explain
the decomposition of [Ti(Cat)3]2- and formation of TiO2 coating in
Ti-based CME is proposed: (1) adsorption, (2) partial
oxidation-intermediate formation, (3) non electrochemical dissociation,
and (4) hydrolysis-precipitation.
KW - Acid mine drainage
KW - Arsenic
KW - Arsenopyrite
KW - Microencapsulation
KW - Ti-catechol complex
LA - eng
IS - 1873-3336 (Electronic)
PT - Journal Article
TA - J Hazard Mater
YR - 2018
DATE- 20180205
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of hazardous materials
EDAT- 20171014
STAT- PubMed-not-MEDLINE
DOCNO- medline/29080485

241 - TOXLINE
TI - Utilization of red mud and Pb/Zn smelter waste for the synthesis of a red
mud-based cementitious material.
AU - Li YC
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China.
AU - Min XB
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China; Chinese National Engineering Research Center for Control
&amp; Treatment of Heavy Metal Pollution, Changsha, Hunan, 410083, China.
Electronic address: mxbcsu@163.com.
AU - Ke Y
AD - Chinese National Engineering Research Center for Control &amp; Treatment of
Heavy Metal Pollution, Changsha, Hunan, 410083, China; School of Materials Science
and Engineering, Central South University, Changsha, Hunan, 410083, China.
AU - Chai LY
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China; Chinese National Engineering Research Center for Control
&amp; Treatment of Heavy Metal Pollution, Changsha, Hunan, 410083, China.
AU - Shi MQ
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China; Chinese National Engineering Research Center for Control
&amp; Treatment of Heavy Metal Pollution, Changsha, Hunan, 410083, China.
AU - Tang CJ
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China; Chinese National Engineering Research Center for Control
&amp; Treatment of Heavy Metal Pollution, Changsha, Hunan, 410083, China.
AU - Wang QW
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China; Chinese National Engineering Research Center for Control
&amp; Treatment of Heavy Metal Pollution, Changsha, Hunan, 410083, China.
AU - Liang YJ
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China.
AU - Lei J
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China.
AU - Liu DG
AD - School of Metallurgy and Environment, Central South University, Changsha,
Hunan, 410083, China.
SO - J Hazard Mater. 2018, Feb 15; 344:343-349. [Journal of hazardous
materials]
AB - A new method in which Pb/Zn smelter waste containing arsenic and heavy
metals (arsenic sludge), red mud and lime are utilized to prepare red
mud-based cementitious material (RCM) is proposed in this study. XRD, SEM,
FTIR and unconfined compressive strength (UCS) tests were employed to
assess the physicochemical properties of RCM. In addition, ettringite and
iron oxide-containing ettringite were used to study the hydration
mechanism of RCM. The results show that the UCS of the RCM (red
mud+arsenic sludge+lime) was higher than that of the binder (red
mud+arsenic sludge). When the mass ratio of m (binder): m (lime) was 94:6
and then maintained 28days at ambient temperature, the UCS reached
12.05MPa. The red mud has potential cementitious characteristics, and the
major source of those characteristics was the aluminium oxide. In the red
mud-arsenic sludge-lime system, aluminium oxide was effectively activated
by lime and gypsum to form complex hydration products. Some of the
aluminium in ettringite was replaced by iron to form calcium sulfoferrite
hydrate. The BCR and leaching toxicity results show that the leaching
concentration was strongly dependent on the chemical speciation of arsenic
and the hydration products. Therefore, the investigated red mud and
arsenic sludge can be successfully utilized in cement composites to create
a red mud-based cementitious material.
KW - Arsenic sludge
KW - Red mud
KW - Red mud-based cementitious material
KW - Unconfined compressive strength
LA - eng
IS - 1873-3336 (Electronic)
PT - Journal Article
TA - J Hazard Mater
YR - 2018
DATE- 20180205
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of hazardous materials
EDAT- 20171023
STAT- PubMed-not-MEDLINE
DOCNO- medline/29080487

242 - TOXLINE
TI - Metabolism of a Phenylarsenical in Human Hepatic Cells and Identification
of a New Arsenic Metabolite.
AU - Liu Q
AD - Department of Laboratory Medicine and Pathology, Faculty of Medicine and
Dentistry, University of Alberta , 10-102 Clinical Sciences Building, Edmonton,
Alberta, Canada T6G 2G3.
AU - Leslie EM
AD - Department of Physiology, Faculty of Medicine and Dentistry, University of
Alberta , 7-08A Medical Sciences Building, Edmonton, Alberta, Canada T6G 2H7.
AU - Moe B
AD - Alberta Centre for Toxicology, Department of Physiology and Pharmacology,
Faculty of Medicine, University of Calgary , Calgary, Alberta, Canada T2N 4N1.
AU - Zhang H
AD - Department of Laboratory Medicine and Pathology, Faculty of Medicine and
Dentistry, University of Alberta , 10-102 Clinical Sciences Building, Edmonton,
Alberta, Canada T6G 2G3.
AU - Douglas DN
AD - Department of Surgery, Faculty of Medicine and Dentistry, University of
Alberta, Walter C. Mackenzie Health Sciences Centre , Edmonton, Alberta, Canada T6G
2B7.
AU - Kneteman NM
AD - Department of Surgery, Faculty of Medicine and Dentistry, University of
Alberta, Walter C. Mackenzie Health Sciences Centre , Edmonton, Alberta, Canada T6G
2B7.
AU - Le XC
AD - Department of Laboratory Medicine and Pathology, Faculty of Medicine and
Dentistry, University of Alberta , 10-102 Clinical Sciences Building, Edmonton,
Alberta, Canada T6G 2G3.
SO - Environ Sci Technol. 2018, Feb 06; 52(3):1386-1392. [Environmental science
& technology]
AB - Environmental contamination and human consumption of chickens could result
in potential exposure to Roxarsone (3-nitro-4-hydroxyphenylarsonic acid),
an organic arsenical that has been used as a chicken feed additive in many
countries. However, little is known about the metabolism of Roxarsone in
humans. The objective of this research was to investigate the metabolism
of Roxarsone in human liver cells and to identify new arsenic metabolites
of toxicological significance. Human primary hepatocytes and
hepatocellular carcinoma HepG2 cells were treated with 20 or 100 &mu;M
Roxarsone. Arsenic species were characterized using a strategy of
complementary chromatography and mass spectrometry. The results showed
that Roxarsone was metabolized to more than 10 arsenic species in human
hepatic cells. A new metabolite was identified as a thiolated Roxarsone.
The 24 h IC50 values of thiolated Roxarsone for A549 lung cancer cells and
T24 bladder cancer cells were 380 &plusmn; 80 and 42 &plusmn; 10 &mu;M,
respectively, more toxic than Roxarsone, whose 24 h IC50 values for A549
and T24 were 9300 &plusmn; 1600 and 6800 &plusmn; 740 &mu;M, respectively.
The identification and toxicological studies of the new arsenic metabolite
are useful for understanding the fate of arsenic species and assessing the
potential impact of human exposure to Roxarsone.
LA - eng
IS - 1520-5851 (Electronic)
PT - Journal Article
TA - Environ Sci Technol
YR - 2018
DATE- 20180206
CITO- NLM
CS - United States
FJT - Environmental science &amp; technology
EDAT- 20180117
STAT- In-Data-Review
DOCNO- medline/29280623

243 - TOXLINE
TI - Secondhand smoke is associated with heavy metal concentrations in
children.
AU - Li L
AD - The Department of Pediatrics, First Affiliated Hospital of Zhengzhou
University, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China.
yiodbc3188@163.com.
AU - Guo L
AD - The Department of Pediatrics, First Affiliated Hospital of Zhengzhou
University, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China.
AU - Chen X
AD - The Department of Pediatrics, First Affiliated Hospital of Zhengzhou
University, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China.
AU - Xiang M
AD - The Department of Pediatrics, First Affiliated Hospital of Zhengzhou
University, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China.
AU - Yang F
AD - The Department of Pediatrics, First Affiliated Hospital of Zhengzhou
University, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China.
AU - Ren JC
AD - The Department of Pediatrics, First Affiliated Hospital of Zhengzhou
University, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China.
AU - Zhang GH
AD - The Department of Pediatrics, First Affiliated Hospital of Zhengzhou
University, Zhengzhou University, 100 Kexue Road, Zhengzhou, 450001, China.
SO - Eur J Pediatr. 2018, Feb; 177(2):257-264. [European journal of pediatrics]
AB - Secondhand smoke (SHS) has adverse effects on health, particularly for
children. Our purpose was to analyze the correlation between SHS exposure
and heavy metal concentrations in children. The investigation was
conducted in Xinxiang County, Henan Province, China, from August 2015 to
December 2015. In total, 821 students (433 boys and 388 girls) were
recruited, and the contents of heavy metals in their hair-including
chromium, manganese, nickel, arsenic, lead, and cadmium-were detected by
ICP-MS. The children's parents were informed, and a questionnaire was
conducted, which included questions about smoking habits and demographic
characteristics. Our results indicate that all parent smokers are fathers,
48.9% of fathers who are smokers, but 25.2% of fathers smoke in front of
their children. The levels of chromium (median girls vs boys, &mu;g/g)
(2.36 vs 2.06, p&thinsp; < &thinsp;0.001), nickel (1.28 vs 0.97,
p&thinsp; < &thinsp;0.001), arsenic (0.55 vs 0.49,
p&thinsp; < &thinsp;0.001), and lead (2.73 vs 2.16,
p&thinsp; < &thinsp;0.001) in girls were significantly higher than in
boys. The levels of cadmium (median, SHS group vs control: 0.43 vs 0.29
(&mu;g/g), p&thinsp; < &thinsp;0.001) and lead (median, SHS group vs
control: 2.71 vs 2.27 (&mu;g/g), p&thinsp;=&thinsp;0.007) in the SHS group
were significantly higher than in the control. Multi-linear regression
analysis indicated that SHS exposure in children is very likely to be
correlated with increasing levels of lead (&beta; (95% CI): 0.53
(0.99-5.14), p&thinsp;=&thinsp;0.023) and cadmium (&beta; (95% CI): 0.43
(0.14-0.73), p&thinsp;=&thinsp;0.003) in their hair. In conclusion,
children exposed to SHS have increased lead and cadmium accumulations in
the body.
AB - CONCLUSION: In our study, 821 students (433 boys and 388 girls) were
recruited, and the contents of heavy metals in their hair-including
chromium, manganese, nickel, arsenic, lead, and cadmium-were detected by
ICP-MS. And the secondhand smoking (SHS) exposure was inquired by
face-to-face investigation of their parents. We illustrated that children
exposed to SHS have increased lead and cadmium accumulations in the body.
What is Known: &bull; Secondhand smoke (SHS) has adverse effects on
health, particularly for children. &bull; There might be correlation
between SHS exposure and heavy metal concentrations in children. What is
New: &bull; The levels of chromium, nickel, arsenic, and lead in girls
were significantly higher than in boys. &bull; SHS exposure in children
was correlated with increasing levels of lead and cadmium in their hair
because of exposure to SHS.
KW - Cadmium
KW - Children
KW - Hair
KW - Heavy metal
KW - ICP-MS
KW - Lead
KW - Secondhand smoke
LA - eng
IS - 1432-1076 (Electronic)
PT - Journal Article
TA - Eur J Pediatr
YR - 2018
DATE- 20180601
CITO- NLM
CS - Germany
CSET- IM
FJT - European journal of pediatrics
EDAT- 20171209
STAT- MEDLINE
CM - Cites: N Z Med J. 2016 Apr 01;129(1432):16-25 (medline /27356248)
CM - Cites: BMC Public Health. 2013 Feb 01;13:93 (medline /23368999)
CM - Cites: J Environ Biol. 2016 Jan;37(1):163-8 (medline /26930875)
CM - Cites: Biol Trace Elem Res. 2012 Jul;148(1):11-7 (medline /22322881)
CM - Cites: J Periodontal Res. 2017 Feb;52(1):83-88 (medline /27016267)
CM - Cites: Ecotoxicol Environ Saf. 2003 Jul;55(3):293-9 (medline /12798763)
CM - Cites: Am J Epidemiol. 2012 Jan 1;175(1):43-53 (medline /22143821)
CM - Cites: Bull Environ Contam Toxicol. 2012 Jul;89(1):125-8 (medline
/22527001)
CM - Cites: Tob Control. 2015 Nov;24 Suppl 4:iv55-9 (medline /25335903)
CM - Cites: Am J Prev Med. 2007 Jun;32(6):542-3 (medline /17533072)
CM - Cites: Nicotine Tob Res. 2016 Nov;18(11):2075-2082 (medline /27287390)
CM - Cites: Am J Hypertens. 2015 Dec;28(12):1480-8 (medline /25944878)
CM - Cites: Can J Public Health. 2015 Jun 24;106(6):e369-74 (medline /26680427)
CM - Cites: Int J Tuberc Lung Dis. 2014 Nov;18(11):1285-91 (medline /25299859)
CM - Cites: Ann Epidemiol. 2013 Oct;23(10):652-61 (medline /23969303)
CM - Cites: Exp Toxicol Pathol. 2008 Jun;60(2-3):141-56 (medline /18485684)
CM - Cites: Environ Res. 2016 Feb;145:116-25 (medline /26656512)
CM - Cites: Chemosphere. 2016 Feb;144:1960-5 (medline /26547876)
CM - Cites: Pediatr Int. 2017 Jan;59(1):68-73 (medline /27337344)
CM - Cites: Cent Eur J Public Health. 2014 Dec;22(4):273-6 (medline /25622488)
CM - Cites: Sci Total Environ. 2013 Jan 15;443:650-61 (medline /23220757)
CM - Cites: Lancet Oncol. 2009 Nov;10(11):1033-4 (medline /19891056)
CM - Cites: J Natl Cancer Inst. 1999 Jul 21;91(14 ):1194-210 (medline
/10413421)
CM - Cites: Int J Environ Res Public Health. 2017 Aug 14;14 (8):null (medline
/28805752)
CM - Cites: Environ Toxicol Pharmacol. 2014 Nov;38(3):1016-24 (medline
/25461563)
CM - Cites: Am J Epidemiol. 2006 Jun 15;163(12):1091-100 (medline /16597704)
DOCNO- medline/29224186

244 - TOXLINE
TI - Effect of selenium induced seed priming on arsenic accumulation in rice
plant and subsequent transmission in human food chain.
AU - Moulick D
AD - Department of Environmental Science, University of Kalyani, Nadia, West
Bengal, India. Electronic address: drubha31@gmail.com.
AU - Santra SC
AD - Department of Environmental Science, University of Kalyani, Nadia, West
Bengal, India. Electronic address: scsantra@yahoo.com.
AU - Ghosh D
AD - ICAR - Directorate of Weed Research, Jabalpur, Madhya Pradesh, India.
Electronic address: dghoshagro@gmail.com.
SO - Ecotoxicol Environ Saf. 2018, May 15; 152:67-77. [Ecotoxicology and
environmental safety]
AB - The south-east Asian countries are facing a serious threat of arsenic (As)
toxicity due to extensive use of As contaminated groundwater for rice
cultivation. This experiment was configured to assess the consequences of
rice seed priming with selenium (Se) and cultivation in As free and As
contaminated soil. The experiment was arranged in a factorial complete
randomized design having two factors viz. seed priming and soil As stress
with total twenty-five treatment combinations replicated thrice. Seed
priming with Se promotes growth, yield under both As free and As stressed
conditions. Se supplementation considerably enhanced the tiller numbers,
chlorophyll content, plant height, panicle length and test weight of rice
by 23.1%, 23.4%, 15.6% and 30.1%, respectively. When cultivated in As
spiked soil and compared with control, Se primed plant enhance growth and
yield by reducing As translocation from root to aerial parts, expressed as
translocation factor (TF). A reduction of TF root to shoot (46.96%), TF
root to husk (36.78-38.01%), TF root to grain (39.63%) can be seen among
the Se primed plants than unprimed plants both cultivated in similar As
stress. Besides these, a noteworthy reduction in estimated daily intake
(EDI) and cancer risk (CR) were also noticed with the consumption of
cooked rice obtained after cooking of brown rice of Se primed plants than
their unprimed counterparts.
KW - Arsenic
KW - Cancer risk (CR)
KW - Estimated daily intake (EDI)
KW - Rice
KW - Seed priming technology
KW - Selenium
RN - H6241UJ22B
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180601
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180204
STAT- MEDLINE
DOCNO- medline/29407784

245 - TOXLINE
TI - Protective Effect of Ellagic Acid Against Sodium Arsenite-Induced Cardio-
and Hematotoxicity in Rats.
AU - Goudarzi M
AD - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences,
Ahvaz, Iran.
AU - Fatemi I
AD - Physiology-Pharmacology Research Center, Rafsanjan University of Medical
Sciences, Rafsanjan, Iran.
AU - Siahpoosh A
AD - Department of Pharmacognosy, Faculty of Pharmacy, Ahvaz Jundishapur
University of Medical Sciences, Ahvaz, Iran.
AU - Sezavar SH
AD - Research Center for Prevention of Cardiovascular Disease, Institute of
Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
AU - Mansouri E
AD - Cellular and Molecular Research Center, Department of Anatomical Sciences,
Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AU - Mehrzadi S
AD - Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran.
Sa_mehrzadi@yahoo.com.
SO - Cardiovasc Toxicol. 2018, Jan 30. [Cardiovascular toxicology]
AB - Ellagic acid (EA) is a phenolic constituent in certain fruits and nuts
with wide range of biological activities, including potent antioxidant,
antidiabetic, anti-inflammatory, anticancer and antimutagen properties.
The aim of this study was to evaluate the effect of EA on sodium arsenic
(SA)-induced cardio- and hematotoxicity in rats. Animals were divided into
five groups. The first group was used as control. Group 2 was orally
treated with sodium arsenite (SA, 10 mg/kg) for 21 days. Group 3
was orally treated with EA (30 mg/kg) for 14 days. Groups 4 and
5 were orally treated with SA for 7 days prior to EA (10 and
30 mg/kg, respectively) treatment and continued up to 21 days
simultaneous with SA administration. Various biochemical, histological and
molecular biomarkers were assessed in blood and heart. The results
indicate that SA-intoxicated rats display significantly higher levels of
plasma cardiac markers (AST, CK-MB, LDH and cTnI) than normal control
animals. Moreover, an increase in MDA and NO with depletion of GSH and
activities of CAT, SOD and GPx occurred in the heart of rats treated with
SA. Furthermore, SA-treated rats showed significantly lower WBC, RBC, HGB,
HCT and PLT and significantly higher MCV and MCH. Administration of EA
(30 mg/kg) resulted in a significant reversal of hematological and
cardiac markers in arsenic-intoxicated rats. These biochemical
disturbances were supported by histopathological observations of the
heart. In conclusion, the results of this study suggest that EA treatment
exerts a significant protective effect on SA-induced cardio- and
hematotoxicity.
KW - Cardioprotection
KW - Ellagic acid
KW - Hematological parameters
KW - Rat
KW - Sodium arsenite
LA - eng
IS - 1559-0259 (Electronic)
PT - Journal Article
TA - Cardiovasc Toxicol
YR - 2018
DATE- 20180131
CITO- NLM
CS - United States
FJT - Cardiovascular toxicology
EDAT- 20180130
STAT- Publisher
DOCNO- medline/29383632

246 - TOXLINE
TI - Serum lipid, lipoprotein and apolipoprotein profiles in workers exposed to
low arsenic levels: Lipid profiles and occupational arsenic exposure.
AU - Ledda C
AD - Occupational Medicine, Department of Clinical and Experimental Medicine,
University of Catania, Catania, Italy. Electronic address: cledda@unict.it.
AU - Iavicoli I
AD - Occupational Medicine, Department of Public Health, University of Naples
Federico II, Naples, Italy.
AU - Bracci M
AD - Occupational Medicine, Department of Clinical and Molecular Sciences,
Polytechnic University of Marche, Ancona, Italy.
AU - Avola R
AD - Biochemistry, Department of Biomedical Sciences and Biotechnology, University
of Catania, Catania, Italy.
AU - Senia P
AD - Occupational Medicine, Department of Clinical and Experimental Medicine,
University of Catania, Catania, Italy.
AU - Santarelli L
AD - Occupational Medicine, Department of Clinical and Molecular Sciences,
Polytechnic University of Marche, Ancona, Italy.
AU - Pomara C
AD - Megal Medicine, Department of Clinical and Experimental Medicine, University
of Foggia, Foggia, Italy; Department of Anatomy, University of Malta, Msida, Malta.
AU - Rapisarda V
AD - Occupational Medicine, Department of Clinical and Experimental Medicine,
University of Catania, Catania, Italy.
SO - Toxicol Lett. 2018, Jan 05; 282:49-56. [Toxicology letters]
AB - Epidemiologic studies have reported that exposure to arsenic (As) is
associated with higher risk of cardiovascular disease (i.e., coronary
heart disease and peripheral arterial heart disease) and mortality. This
cross-sectional study aimed to compare serum lipid, lipoprotein, and
apolipoprotein profiles in workers exposed to As. The subjects of this
study included 57 workers exposed to As and 57 controls. Demographic
characteristics and occupational information were collected through
questionnaires. Exposure to As was assessed in indoor air of a workplace
and determined using the creatinine values in the urine. Blood samples
were collected using immunochemistry and nephelometry to measure the
levels of total cholesterol (CHOL), triglycerides (TRIG), high-density
lipoprotein (HDL), low-density lipoprotein (LDL), lipoprotein(a) (Lp(a)),
apolipoprotein-A1 (Apo-A1), and apolipoprotein-B (Apo-B). No significant
difference in the demographic data was detected between the two groups.
Urinary As concentration was significantly (p < 0.001) higher in exposed
subjects than in the controls (13.4&plusmn;6.1 and
4.4&plusmn;6.1&mu;g/gCreat, respectively). No statistically significant
differences were observed in CHOL, TRIG, HDL, and LDL concentrations
between the two groups. Lp(a), Apo-B, and Apo-B/Apo-A1 ratio values were
significantly higher and the Apo-A1 level was significantly lower in the
exposed group than in the control subjects. Regression analysis
highlighted a significant (p < 0.001) association between urinary As and
Lp(a), Apo-A1, and Apo-B concentration, and Apo-B/Apo-A1 ratio. This study
revealed the influence of As on apolipoproteins, suggesting a potential
risk of cardiovascular diseases in subjects exposed to low levels of As.
KW - Cardiovascular diseases
KW - Environment
KW - Exposure assessment
KW - Heavy metals
KW - Occupational medicine
KW - Work place
RN - N712M78A8G
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20171201
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Toxicology letters
EDAT- 20171018
STAT- MEDLINE
DOCNO- medline/29054558

247 - TOXLINE
TI - Organic arsenicals target thioredoxin reductase followed by oxidative
stress and mitochondrial dysfunction resulting in apoptosis.
AU - Fan XY
AD - State Key Laboratory of Virology, Key Laboratory of Analytical Chemistry for
Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan
University, Wuhan 430072, PR China.
AU - Liu YJ
AD - State Key Laboratory of Virology, Key Laboratory of Analytical Chemistry for
Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan
University, Wuhan 430072, PR China.
AU - Chen K
AD - Collaborative Innovation Center of Chemistry for Life Sciences, School of
Life Sciences, University of Sciences and Technology of China, Hefei 230027, PR
China.
AU - Jiang FL
AD - State Key Laboratory of Virology, Key Laboratory of Analytical Chemistry for
Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan
University, Wuhan 430072, PR China.
AU - Hu YJ
AD - College of Chemistry and Chemical Engineering, Hubei Normal University,
Huangshi 435002, PR China.
AU - Liu D
AD - Collaborative Innovation Center of Chemistry for Life Sciences, School of
Life Sciences, University of Sciences and Technology of China, Hefei 230027, PR
China.
AU - Liu Y
AD - State Key Laboratory of Virology, Key Laboratory of Analytical Chemistry for
Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan
University, Wuhan 430072, PR China; College of Chemistry and Chemical Engineering,
Hubei Normal University, Huangshi 435002, PR China; College of Chemistry and
Chemical Engineering, Wuhan University of Science and Technology, Wuhan 430081, PR
China. Electronic address: yiliuchem@whu.edu.cn.
AU - Ge YS
AD - Collaborative Innovation Center of Chemistry for Life Sciences, School of
Life Sciences, University of Sciences and Technology of China, Hefei 230027, PR
China. Electronic address: geyushu@ustc.edu.cn.
SO - Eur J Med Chem. 2018, Jan 01; 143:1090-1102. [European journal of
medicinal chemistry]
AB - Considering the vital role of cellular redox state, more and more
researches focus on the design of drugs targeting thioredoxin reductase
(TrxR), an important enzyme in maintaining the balance of cellular redox.
Here two organic arsenicals, 2-(((4-(1,3,2-dithiarsinan-2-yl) phenyl)
imino) methyl) phenol (PIM-PAO-PDT) and N-(4-(1,3,2-dithiarsinan-2-yl)
phenyl)-2-hydroxybenzamide (PAM-PAO-PDT), bearing the S-As-S chemical
scaffold and different linking groups have been synthesized, and both of
them show the better inhibitory activity and selectivity towards
HL-60 cells. Importantly, it is illustrated that they can target TrxR
selectively and inhibit its activity via the disturbance for Cys83 and
Cys88 located in conserved active sites. Afterwards, the cells suffer from
the burst of ROS, consumption of antioxidants and high sensitivity for
oxidants, which further damage the mitochondria leading to dysfunction
including the collapse of membrane potential, ATP level decline,
mitochondrial membrane swelling, MPTP opening, Ca2+ and cytochrome c
release. Then the mitochondria-dependent apoptosis is triggered by
PIM-PAO-PDT and PAM-PAO-PDT, which can also be deterred in the presence of
NAC, DTT or LA. Although the organic arsenicals can suppress TrxR
activity, the following oxidative stress and mitochondrial dysfunction are
the main causes for apoptosis.
KW - Mitochondrial dysfunction
KW - Organic arsenicals
KW - Oxidative stress
KW - TrxR
RN - EC 1.8.1.9
LA - eng
IS - 1768-3254 (Electronic)
PT - Journal Article
TA - Eur J Med Chem
YR - 2018
DATE- 20180101
CI - Copyright &copy; 2017 Elsevier Masson SAS. All rights reserved.
CITO- NLM
CS - France
CSET- IM
FJT - European journal of medicinal chemistry
EDAT- 20170506
STAT- MEDLINE
DOCNO- medline/29150332

248 - TOXLINE
TI - Biochemical responses and accumulation patterns of Mytilus
galloprovincialis exposed to thermal stress and Arsenic contamination.
AU - Coppola F
AD - Departamento de Biologia &amp; CESAM, Universidade de Aveiro, 3810-193
Aveiro, Portugal.
AU - Almeida �
AD - Departamento de Biologia &amp; CESAM, Universidade de Aveiro, 3810-193
Aveiro, Portugal.
AU - Henriques B
AD - Departamento de Qu�mica &amp; CESAM, Universidade de Aveiro, 3810-193 Aveiro,
Portugal; CIIMAR, Universidade do Porto, 4050-123 Porto, Portugal.
AU - Soares AMVM
AD - Departamento de Biologia &amp; CESAM, Universidade de Aveiro, 3810-193
Aveiro, Portugal.
AU - Figueira E
AD - Departamento de Biologia &amp; CESAM, Universidade de Aveiro, 3810-193
Aveiro, Portugal.
AU - Pereira E
AD - Departamento de Qu�mica &amp; CESAM, Universidade de Aveiro, 3810-193 Aveiro,
Portugal.
AU - Freitas R
AD - Departamento de Biologia &amp; CESAM, Universidade de Aveiro, 3810-193
Aveiro, Portugal. Electronic address: rosafreitas@ua.pt.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:954-962. [Ecotoxicology and
environmental safety]
AB - Organisms in marine systems are exposed to multiple stressors that create
a range of associated environmental and ecotoxicological risks. Examples
of stressors include alterations related to climate change, such as
temperature increase, and the exposure to pollutants arising from human
activities. The present study evaluated the impacts of Arsenic exposure
(1mg/L) and warming (21&deg;C) in Mytilus galloprovincialis, acting alone
and in combination. Our results demonstrated that both Arsenic exposure
and warming induced oxidative stress and reduced mussels metabolism, with
changes becoming more prominent with the exposure time and when mussels
were exposed to both stressors in combination. Furthermore, results
obtained showed higher As accumulation in organisms exposed to warming
treatments. The present study showed that under warming scenarios, the
negative impacts induced by As may be enhanced in ecologically and
economically relevant bivalves, with potential impacts on population
stocks due to increased sensitivity to pollutants, which may eventually
result in biodiversity loss and socio-economic impacts.
KW - Bioaccumulation
KW - Climate change
KW - Metabolism
KW - Metalloids
KW - Mussels
KW - Oxidative stress
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180308
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171005
STAT- MEDLINE
DOCNO- medline/29029381

249 - TOXLINE
TI - Chemo-sensitivity of Two-dimensional Monolayer and Three-dimensional
Spheroid of Breast Cancer MCF-7 Cells to Daunorubicin, Docetaxel, and
Arsenic Disulfide.
AU - Uematsu N
AD - Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences, Tokyo, Japan.
AU - Zhao Y
AD - Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical
Sciences, Beijing, P.R. China.
AU - Kiyomi A
AD - Department of Drug Safety and Risk Management, School of Pharmacy, Tokyo
University of Pharmacy and Life Sciences, Tokyo, Japan.
AU - Yuan BO
AD - Department of Applied Biochemistry, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences, Tokyo, Japan.
AU - Onda K
AD - Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences, Tokyo, Japan.
AU - Tanaka S
AD - Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences, Tokyo, Japan.
AU - Sugiyama K
AD - Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences, Tokyo, Japan.
AU - Sugiura M
AD - Department of Drug Safety and Risk Management, School of Pharmacy, Tokyo
University of Pharmacy and Life Sciences, Tokyo, Japan.
AU - Takagi N
AD - Department of Applied Biochemistry, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences, Tokyo, Japan.
AU - Hayakawa A
AD - Organization for Promoting Life Science and Culture, Nagoya, and Department
of Plastic and Reconstructive Surgery, Nagoya University of Graduate School of
Medicine, Nagoya, Japan.
AU - Hirano T
AD - Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences, Tokyo, Japan hiranot@toyaku.ac.jp.
SO - Anticancer Res. 2018, 04; 38(4):2101-2108. [Anticancer research]
AB - BACKGROUND/AIM: Chemo-sensitivity of two-dimensional (2D) monolayers and
three-dimensional (3D) spheroids of human breast cancer MCF-7 cells were
investigated.
AB - MATERIALS AND METHODS: MCF-7 cells were cultured in monolayers or
spheroids established using a thermo-reversible gelatin polymer, in the
presence of daunorubicin, docetaxel, or As2S2 Cell proliferation was
examined by a Cell Counting Kit-8 assay.
AB - RESULTS: Daunorubicin, docetaxel, and As2S2 dose-dependently decreased the
MCF-7 cell proliferation in both 2D- and 3D-culture systems. The 3D
spheroids were less sensitive to these agents than the 2D cultured cells.
Verapamil, an inhibitor of P-glycoprotein, partially enhanced the
antiproliferative effects of the agents. DL-buthionine-(S, R)-sulfoximine
significantly increased (p < 0.05), while N-acetyl-L-cysteine
significantly inhibited the antiproliferative effects of As2S2
(p < 0.003).
AB - CONCLUSION: The 3D spheroids showed less sensitivity to the
antiprolliferative efficacies of anticancer agents than the 2D cultured
cells. P-Glycoprotein is suggested to be partially implicated in drug
resistance. Reduction of cellular glutathione level enhanced the As2S2
cytotoxicity.
KW - *2D monolayer
KW - *3D spheroid
KW - *Daunorubicin
KW - *arsenic disulfide
KW - *breast cancer MCF-7 cells
KW - *docetaxel
RN - 15H5577CQD
RN - 56320-22-0
RN - ZS7284E0ZP
LA - eng
IS - 1791-7530 (Electronic)
PT - Journal Article
TA - Anticancer Res
YR - 2018
DATE- 20180427
CI - Copyright&copy; 2018, International Institute of Anticancer Research (Dr.
George J. Delinasios), All rights reserved.
CITO- NLM
CS - Greece
CSET- IM
FJT - Anticancer research
STAT- MEDLINE
DOCNO- medline/29599328

250 - TOXLINE
TI - Impact of inorganic ions and natural organic matter on arsenates removal
by ferrate(VI): Understanding a complex effect of phosphates ions.
AU - Kola&#345;�k J
AD - Regional Centre of Advanced Technologies and Materials, Departments of
Physical Chemistry and Experimental Physics, Faculty of Science, Palack� University
in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic.
AU - Prucek R
AD - Regional Centre of Advanced Technologies and Materials, Departments of
Physical Chemistry and Experimental Physics, Faculty of Science, Palack� University
in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic. Electronic
address: robert.prucek@upol.cz.
AU - Tu&#269;ek J
AD - Regional Centre of Advanced Technologies and Materials, Departments of
Physical Chemistry and Experimental Physics, Faculty of Science, Palack� University
in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic.
AU - Filip J
AD - Regional Centre of Advanced Technologies and Materials, Departments of
Physical Chemistry and Experimental Physics, Faculty of Science, Palack� University
in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic.
AU - Sharma VK
AD - Regional Centre of Advanced Technologies and Materials, Departments of
Physical Chemistry and Experimental Physics, Faculty of Science, Palack� University
in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic; Program for the
Environment and Sustainability, Department of Environmental and Occupational
Health, School of Rural Public Health, Texas A&amp;M University, 1266 TAMU, College
Station, TX 77843, USA.
AU - Zbo&#345;il R
AD - Regional Centre of Advanced Technologies and Materials, Departments of
Physical Chemistry and Experimental Physics, Faculty of Science, Palack� University
in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic. Electronic
address: radek.zboril@upol.cz.
SO - Water Res. 2018, May 15; 141:357-365. [Water research]
AB - Arsenic compounds are carcinogenic to humans and are typically removed
from contaminated water using various sorbents. The ionic composition
plays a significant role in arsenate removal efficiency during the process
of water remediation. Here, we quantify the effects of natural ions
(chlorides, nitrates, carbonates, sulfates, and phosphates) and humic acid
on the removal of arsenates by ferrate(VI) at pH&#8239;=&#8239;6.6. In the
experiments, the initial concentration of arsenates was
10&#8239;mg&#8239;L-1 (as As) and the concentrations of ions varied in the
range from 5 to 100&#8239;mg&#8239;L-1 of element in ionic form and humic
acid. The achieved results show that only phosphate ions had principle
influence on the efficiency of arsenate removal by ferrate(VI). The effect
of phosphates was elucidated by applying transmission electron microscopy,
energy-dispersive X-ray spectroscopy, and low temperature in-field 57Fe
M�ssbauer spectroscopy to solid samples, prepared under different
weight ratios of ferrate(VI), arsenates, and phosphates. These results
show three crucial effects of phosphates on the arsenate removal
mechanisms. At low P:As weight ratio (up to 1:1), the incorporation of
arsenate ions into the crystalline structure of
&gamma;-Fe2O3/&gamma;-FeOOH nanoparticles was found to be suppressed by
the presence of phosphates. Thus, arsenates were mainly adsorbed onto the
surface of &gamma;-Fe2O3/&gamma;-FeOOH nanoparticles. Further increase in
the P:As weight ratio (more than 1:1) resulted in the competition between
arsenates and phosphates sorption. With the increased concentration of
phosphate ions, the number of arsenates on the surface of
&gamma;-Fe2O3/&gamma;-FeOOH nanoparticles was reduced. Finally, the
complexation of iron(III) ions with phosphate ions occurred, leading to a
decrease in the arsenates removal efficiency, which resulted from a lower
content of precipitated &gamma;-Fe2O3/&gamma;-FeOOH nanoparticles. All
these aspects need to be considered prior to application of ferrate(VI)
for arsenates removal in real natural waters.
KW - Arsenates
KW - Fe(VI)
KW - Natural ions
KW - Oxidation
KW - Phosphates
KW - Reaction mechanism
KW - Water treatment
LA - eng
IS - 1879-2448 (Electronic)
PT - Journal Article
TA - Water Res
YR - 2018
DATE- 20180611
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Water research
EDAT- 20180515
STAT- Publisher
DOCNO- medline/29804022

251 - TOXLINE
TI - Cytoprotective role of ubiquitin against toxicity induced by
polyglutamine-expanded aggregates.
AU - Bae JS
AD - Department of Life Science, University of Seoul, Seoul 02504, Republic of
Korea.
AU - Ryu KY
AD - Department of Life Science, University of Seoul, Seoul 02504, Republic of
Korea. Electronic address: kyryu@uos.ac.kr.
SO - Biochem Biophys Res Commun. 2018, Jun 02; 500(2):344-350. [Biochemical and
biophysical research communications]
AB - Ubiquitin (Ub) homeostasis is important for cellular function and
survival, especially under stress conditions. Recently, we have
demonstrated that Ubc-/- (Ub-deficient) mouse embryonic fibroblasts (MEFs)
exhibited reduced viability under oxidative stress induced by arsenite,
which was not due to dysregulation of the antioxidant response pathway,
but rather due to the potential toxicity caused by the misfolded protein
aggregates. However, it is still not clear whether Ub deficiency is
directly related to the accumulation of toxic protein aggregates, as
arsenite itself triggers protein aggregation and renders cells into
aberrant conditions such as reduced proteasome function and inhibition of
autophagic flux. Therefore, under arsenite treatment, the outcome could be
derived from the combination of multiple defective pathways. Furthermore,
it has also been suggested that ubiquitination status of misfolded
proteins may not be important for the formation of inclusion bodies
composed of misfolded protein aggregates. We therefore wondered whether Ub
deficiency is sufficient to trigger the accumulation of toxic protein
aggregates inside the cells. In this study, we ectopically expressed
polyQ-expanded aggregates (Q103) in MEFs and observed inclusion body
formation at the juxtanuclear region, which was independent of cellular Ub
levels. In contrast to arsenite treatment, polyQ expression did not affect
proteasome function. However, we observed an increased accumulation of
Q103 aggregates in Ubc-/- MEFs, which was due to impaired autophagic
clearance. Finally, we demonstrated that the increased accumulation of
Q103 aggregates under Ub deficiency dramatically reduced the viability of
cells. Therefore, our results suggest that the maintenance of proper
levels of cellular Ub is important to protect cells against the toxicity
induced by the accumulation of protein aggregates.
KW - Aggregates
KW - Autophagy
KW - Polyglutamine
KW - Proteasome
KW - Toxicity
KW - Ubiquitin
LA - eng
IS - 1090-2104 (Electronic)
PT - Journal Article
TA - Biochem Biophys Res Commun
YR - 2018
DATE- 20180429
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Biochemical and biophysical research communications
EDAT- 20180414
STAT- In-Data-Review
DOCNO- medline/29654755

252 - TOXLINE
TI - A review of cinnabar (HgS) and/or realgar (As4S4)-containing traditional
medicines.
AU - Liu J
AD - Key Lab for Basic Pharmacology of Ministry of Education and Joint
International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi
Medical University, Zunyi, Guizhou 563006, China. Electronic address:
Jie@liuonline.com.
AU - Wei LX
AD - Key Lab of Pharmacology and Safety Evaluation of Tibetan Medicine, Northwest
Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.
AU - Wang Q
AD - Department of Toxicology, School of Public Health, Peking University, Beijing
100191, China.
AU - Lu YF
AD - Key Lab for Basic Pharmacology of Ministry of Education and Joint
International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi
Medical University, Zunyi, Guizhou 563006, China.
AU - Zhang F
AD - Key Lab for Basic Pharmacology of Ministry of Education and Joint
International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi
Medical University, Zunyi, Guizhou 563006, China.
AU - Shi JZ
AD - Central Lab of Guiyang Traditional Medical College, Guiyang 550004, China.
AU - Li C
AD - Key Lab of Pharmacology and Safety Evaluation of Tibetan Medicine, Northwest
Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.
AU - Cherian MG
AD - University of Western Ontario, London ON, Canada N6A 5C1.
SO - J Ethnopharmacol. 2018, Jan 10; 210:340-350. [Journal of
ethnopharmacology]
AB - ETHNOPHARMOCOLOGICAL RELEVANCE: Herbo-metallic preparations have a long
history in the treatment of diseases, and are still used today for
refractory diseases, as adjuncts to standard therapy, or for economic
reasons in developing countries.
AB - AIM OF THE REVIEW: This review uses cinnabar (HgS) and realgar (As4S4) as
mineral examples to discuss their occurrence, therapeutic use,
pharmacology, toxicity in traditional medicine mixtures, and research
perspectives.
AB - MATERIALS AND METHODS: A literature search on cinnabar and realgar from
PubMed, Chinese pharmacopeia, Google and other sources was carried out.
Traditional medicines containing both cinnabar and realgar
(An-Gong-Niu-Huang Wan, Hua-Feng-Dan); mainly cinnabar (Zhu-Sha-An-Shen
Wan; Zuotai and Dangzuo), and mainly realgar (Huang-Dai Pian; Liu-Shen
Wan; Niu-Huang-Jie-Du) are discussed.
AB - RESULTS: Both cinnabar and realgar used in traditional medicines are
subjected to special preparation procedures to remove impurities. Metals
in these traditional medicines are in the sulfide forms which are
different from environmental mercurials (HgCl2, MeHg) or arsenicals
(NaAsO2, NaH2AsO4). Cinnabar and/or realgar are seldom used alone, but
rather as mixtures with herbs and/or animal products in traditional
medicines. Advanced technologies are now used to characterize these
preparations. The bioaccessibility, absorption, distribution, metabolism
and elimination of these herbo-metallic preparations are different from
environmental metals. The rationale of including metals in traditional
remedies and their interactions with drugs need to be justified. At higher
therapeutic doses, balance of the benefits and risks is critical.
Surveillance of patients using these herbo-metallic preparations is
desired.
AB - CONCLUSION: Chemical forms of mercury and arsenic are a major determinant
of their disposition, efficacy and toxicity, and the use of total Hg and
As alone for risk assessment of metals in traditional medicines is
insufficient.
KW - Arsenic
KW - Cinnabar
KW - Disposition
KW - Efficacy
KW - Herbo-metallic preparations
KW - Mercury
KW - Realgar
KW - Safety evaluation
KW - Zuotai
LA - eng
IS - 1872-7573 (Electronic)
PT - Journal Article
PT - Review
TA - J Ethnopharmacol
YR - 2018
DATE- 20171110
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Ireland
FJT - Journal of ethnopharmacology
EDAT- 20170831
STAT- In-Process
DOCNO- medline/28864167

253 - TOXLINE
TI - Evaluation of kidney injury biomarkers in an adult Mexican population
environmentally exposed to fluoride and low arsenic levels.
AU - Jim�nez-C�rdova MI
AD - Departamento de Toxicolog�a, Centro de Investigaci�n y de Estudios Avanzados
del Instituto Polit�cnico Nacional, Ciudad de M�xico, Mexico.
AU - C�rdenas-Gonz�lez M
AD - Departamento de Toxicolog�a, Centro de Investigaci�n y de Estudios Avanzados
del Instituto Polit�cnico Nacional, Ciudad de M�xico, Mexico.
AU - Aguilar-Madrid G
AD - Unidad de Investigaci�n y Salud en el Trabajo, Instituto Mexicano del Seguro
Social, Ciudad de M�xico, Mexico.
AU - Sanchez-Pe�a LC
AD - Departamento de Toxicolog�a, Centro de Investigaci�n y de Estudios Avanzados
del Instituto Polit�cnico Nacional, Ciudad de M�xico, Mexico.
AU - Barrera-Hern�ndez �
AD - Departamento de Toxicolog�a, Centro de Investigaci�n y de Estudios Avanzados
del Instituto Polit�cnico Nacional, Ciudad de M�xico, Mexico.
AU - Dom�nguez-Guerrero IA
AD - Facultad de Ciencias Qu�micas, Universidad Aut�noma de Chihuahua, Chihuahua,
Mexico.
AU - Gonz�lez-Horta C
AD - Facultad de Ciencias Qu�micas, Universidad Aut�noma de Chihuahua, Chihuahua,
Mexico.
AU - Barbier OC
AD - Departamento de Toxicolog�a, Centro de Investigaci�n y de Estudios Avanzados
del Instituto Polit�cnico Nacional, Ciudad de M�xico, Mexico.
AU - Del Razo LM
AD - Departamento de Toxicolog�a, Centro de Investigaci�n y de Estudios Avanzados
del Instituto Polit�cnico Nacional, Ciudad de M�xico, Mexico. Electronic address:
ldelrazo@cinvestav.mx.
SO - Toxicol Appl Pharmacol. 2018, May 22; 352:97-106. [Toxicology and applied
pharmacology]
AB - Fluoride (F) is a toxicant widely distributed in the environment.
Experimental studies have shown kidney toxicity from F exposure. However,
co-exposure to arsenic (As) has not been considered, and epidemiological
information remains limited. We evaluated the association between F
exposure and urinary kidney injury biomarkers and assessed As co-exposure
interactions. A cross-sectional study was conducted in 239 adults
(18-77&#8239;years old) from three communities in Chihuahua, Mexico.
Exposure to F was assessed in urine and drinking water, and As in urine
samples. We evaluated the urinary concentrations of albumin (ALB),
cystatin-C (Cys-C), kidney injury molecule 1 (KIM-1), clusterin (CLU),
osteopontin (OPN), and trefoil factor 3 (TFF-3). The estimated glomerular
filtration rate (eGFR) was calculated using serum creatinine (Creat)
levels. We observed a positive correlation between water and urine F
concentrations (&rho;&#8239;=&#8239;0.7419, p&#8239; < &#8239;0.0001),
with median values of 1.5&#8239;mg/L and 2&#8239;&mu;g/mL, respectively,
suggesting that drinking water was the main source of F exposure. The
geometric mean of urinary As was 18.55&#8239;ng/mL, approximately 39% of
the urine samples had As concentrations above the human biomonitoring
value (15&#8239;ng/mL). Multiple linear regression models demonstrated a
positive association between urinary F and ALB (&beta;&#8239;=&#8239;0.56,
p&#8239; < &#8239;0.001), Cys-C (&beta;&#8239;=&#8239;0.022,
p&#8239;=&#8239;0.001), KIM-1 (&beta;&#8239;=&#8239;0.048,
p&#8239;=&#8239;0.008), OPN (&beta;&#8239;=&#8239;0.38,
p&#8239;=&#8239;0.041), and eGFR (&beta;&#8239;=&#8239;0.49,
p&#8239;=&#8239;0.03); however, CLU (&beta;&#8239;=&#8239;0.07,
p&#8239;=&#8239;0.100) and TFF-3 (&beta;&#8239;=&#8239;1.14,
p&#8239;=&#8239;0.115) did not show significant associations. No
interaction with As exposure was observed. In conclusion, F exposure was
related to the urinary excretion of early kidney injury biomarkers,
supporting the hypothesis of the nephrotoxic role of F exposure.
KW - Arsenic
KW - Biomarkers
KW - Fluoride
KW - Human Biomonitoring
KW - Kidney Toxicity
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180616
CI - Copyright &copy; 2018. Published by Elsevier Inc.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20180522
STAT- Publisher
DOCNO- medline/29800643

254 - TOXLINE
TI - Accumulation, fractionation, and risk assessment of mercury and arsenic in
the soil-wheat system from the wastewater-irrigated soil in Baiyin,
northwest China.
AU - Zhang Q
AD - Key Laboratory of Western China's Environmental Systems (Ministry of
Education), College of Earth and Environmental Sciences, Lanzhou University,
Tianshui South Road 222, Lanzhou, 730000, Gansu Province, China.
AU - Wang S
AD - Key Laboratory of Western China's Environmental Systems (Ministry of
Education), College of Earth and Environmental Sciences, Lanzhou University,
Tianshui South Road 222, Lanzhou, 730000, Gansu Province, China.
wangshengl@lzu.edu.cn.
AU - Nan Z
AD - Key Laboratory of Western China's Environmental Systems (Ministry of
Education), College of Earth and Environmental Sciences, Lanzhou University,
Tianshui South Road 222, Lanzhou, 730000, Gansu Province, China.
AU - Li Y
AD - Key Laboratory of Western China's Environmental Systems (Ministry of
Education), College of Earth and Environmental Sciences, Lanzhou University,
Tianshui South Road 222, Lanzhou, 730000, Gansu Province, China.
AU - Zang F
AD - Key Laboratory of Western China's Environmental Systems (Ministry of
Education), College of Earth and Environmental Sciences, Lanzhou University,
Tianshui South Road 222, Lanzhou, 730000, Gansu Province, China.
SO - Environ Sci Pollut Res Int. 2018, May; 25(15):14856-14867. [Environmental
science and pollution research international]
AB - Wastewater irrigation can increase metal concentrations in soil and wheat,
thereby posing metal-associated health risk via food ingestion. We
investigated levels of mercury (Hg) and arsenic (As) in roots, husks,
stems, leaves, and grains of wheat and their fractionations in farmland
soil from Baiyin City, an industrial and mining city, northwest China.
Results show that the mean concentrations of Hg in soils from Dongdagou
and Xidagou stream in Baiyin were 8.5 times and three times higher than
local soil background values, respectively. Those of As were 4.5 times and
1.6 times higher, respectively. Most Hg and As were mainly accumulated in
wheat leaves. The spatial distributions of As in soils and grains exhibit
a very similar pattern, which suggest that As pollution in soils might be
predicted by its level in wheat grains. Residual fractions for Hg (RES-Hg)
and As (RES-As) are the highest compared to other fractions, indicating
weak mobility of Hg and As in soil. The crop oral intake hazard quotients
of both Hg and As for children were approximately two times higher than
that for adults, indicating that children have higher exposure risks to
Hg- and As-contaminated wheat. The crop oral intake was the main route of
exposure causing non-carcinogenic and carcinogenic risk for local
residents.
KW - Arsenic
KW - Mercury
KW - Risk assessment
KW - Soil
KW - Wastewater
KW - Wheat
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180531
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180315
STAT- In-Process
CM - Cites: Sci Total Environ. 2016 Aug 1;560-561:204-11 (medline /27101456)
CM - Cites: Food Chem. 2017 Nov 15;235:203-211 (medline /28554627)
CM - Cites: Sci Total Environ. 2014 Jan 15;468-469:843-53 (medline /24076505)
CM - Cites: J Environ Sci (China). 2009;21(6):806-13 (medline /19803087)
CM - Cites: Water Sci Technol. 2001;43(2):187-96 (medline /11380179)
CM - Cites: J Environ Sci (China). 2008;20(3):326-31 (medline /18595400)
CM - Cites: C R Biol. 2009 Jun;332(6):558-66 (medline /19520319)
CM - Cites: Chemosphere. 2016 May;151:94-100 (medline /26930247)
CM - Cites: J Hazard Mater. 2012 Jun 30;221-222:1-18 (medline /22579459)
CM - Cites: Sci Total Environ. 2014 Jan 15;468-469:654-62 (medline /24061056)
CM - Cites: Environ Sci Technol. 2011 Sep 1;45(17):7135-42 (medline /21797214)
CM - Cites: J Emerg Med. 1998 Jan-Feb;16(1):45-56 (medline /9472760)
CM - Cites: Environ Sci Pollut Res Int. 2015 Dec;22(24):19756-63 (medline
/26280396)
CM - Cites: Sci Total Environ. 2006 Apr 1;358(1-3):97-120 (medline /16055168)
CM - Cites: Chemosphere. 2014 Dec;117:737-44 (medline /25461942)
CM - Cites: J Hazard Mater. 2014 May 30;273:272-9 (medline /24751493)
CM - Cites: Chemosphere. 2017 Jan;167:82-90 (medline /27710846)
CM - Cites: Environ Sci Pollut Res Int. 2015 Jun;22(11):8367-74 (medline
/25537285)
CM - Cites: Chemosphere. 2011 Sep;84(11):1563-71 (medline /21722940)
CM - Cites: J Hazard Mater. 2009 Aug 15;167(1-3):745-51 (medline /19211186)
CM -Cites: Chemosphere. 2017 Aug;180:553-563 (medline /28432892)
CM -Cites: Sci Total Environ. 2015 Dec 15;538:644-53 (medline /26322729)
CM -Cites: J Hazard Mater. 2010 Feb 15;174(1-3):455-62 (medline /19825507)
CM -Cites: Ecotoxicol Environ Saf. 2015 Oct;120:377-85 (medline /26114257)
CM -Cites: J Environ Sci (China). 2006;18(6):1124-34 (medline /17294953)
CM -Cites: Sci Total Environ. 2017 Oct 1;595:344-351 (medline /28390313)
CM -Cites: Sci Total Environ. 2015 Apr 15;512-513:143-153 (medline /25617996)
CM -Cites: Environ Pollut. 2008 Apr;152(3):686-92 (medline /17720286)
CM -Cites: Environ Sci Technol. 2006 Oct 1;40(19):6001-6 (medline /17051791)
CM -Cites: Chemosphere. 2013 Oct;93(4):661-7 (medline /23871591)
CM -Cites: Sci Total Environ. 2005 Mar 1;339(1-3):153-66 (medline /15740766)
CM -Cites: Environ Geochem Health. 2012 Jan;34 Suppl 1:143-9 (medline
/21826510)
CM - Cites: Bull Environ Contam Toxicol. 2009 Mar;82(3):343-7 (medline
/18987775)
CM - Cites: Sci Total Environ. 2016 Oct 15;568:245-252 (medline /27300562)
DOCNO- medline/29546511

255 - TOXLINE
TI - Genetic-based dissection of arsenic accumulation in maize using a
genome-wide association analysis method.
AU - Zhao Z
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Zhang H
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Fu Z
AD - Maize Research Institute, Chongqing Academy of Agricultural Sciences,
Chongqing, China.
AU - Chen H
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Lin Y
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Yan P
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Li W
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Xie H
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Guo Z
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Zhang X
AD - Key Laboratory of Wheat and Maize Crops Science, Collaborative Innovation
Center of Henan Grain Crops, College of Agronomy, Henan Agricultural University,
Zhengzhou, China.
AU - Tang J
AD - Hubei Collaborative Innovation Center for Grain Industry, Yangtze University,
Jingzhou, China.
SO - Plant Biotechnol J. 2018, May; 16(5):1085-1093. [Plant biotechnology
journal]
AB - Understanding the mechanism of arsenic (As) accumulation in plants is
important in reducing As's toxicity to plants and its potential risks to
human health. Here, we performed a genome-wide association study to
dissect the genetic basis of the As contents of different maize tissues in
Xixian, which was irrigated with As-rich surface water, and Changge using
an association population consisting of 230 representative maize inbred
lines. Phenotypic data revealed a wide normal distribution and high
repeatability for the As contents in maize tissues. The As concentrations
in maize tissues followed the same trend in the two locations:
kernels <
axes < stems < bracts < leaves. In
total, 15, 16 and 15 non-redundant quantitative trait loci (QTLs)
associated with As concentrations were identified
(P &le; 2.04 &times; 10-6 ) in five tissues from
Xixian, Changge, and the combination of the locations, respectively,
explaining 9.70%-24.65% of the phenotypic variation for each QTL, on
average. Additionally, four QTLs [involving 15 single nucleotide
polymorphisms (SNPs)] were detected in the single and the combined
locations, indicating that these loci/SNPs might be stable across
different environments. The candidate genes associated with these four
loci were predicted. In addition, four non-redundant QTLs (6 SNPs),
including a QTL that was detected in multiple locations according to the
genome-wide association study, were found to co-localize with four
previously reported QTL intervals. These results are valuable to
understand the genetic architecture of As mechanism in maize and
facilitate the genetic improvement of varieties without As toxicity.
KW - arsenic accumulation
KW - genetic loci
KW - genome-wide association analysis
KW - maize tissues
LA - eng
IS - 1467-7652 (Electronic)
PT - Journal Article
TA - Plant Biotechnol J
YR - 2018
DATE- 20180425
CI - &copy; 2017 The Authors. Plant Biotechnology Journal published by Society
for Experimental Biology and The Association of Applied Biologists and
John Wiley &amp; Sons Ltd.
CITO- NLM
CS - England
FJT - Plant biotechnology journal
EDAT- 20171204
STAT- In-Data-Review
CM - Cites: Biomed Res Int. 2015 ;2015 :340812 (medline /26798635)
CM - Cites: Nature. 2010 Jun 3;465(7298):627-31 (medline /20336072)
CM - Cites: Plant Physiol Biochem. 2016 Jun;103:45-52 (medline /26963899)
CM - Cites: PLoS One. 2011;6(10):e25646 (medline /22028786)
CM - Cites: Phytochemistry. 2005 Jul;66(13):1519-28 (medline /15964037)
CM - Cites: Theor Appl Genet. 2016 Aug;129(8):1449-63 (medline /27121008)
CM - Cites: PLoS One. 2016 Apr 14;11(4):e0153610 (medline /27077373)
CM - Cites: PLoS One. 2011;6(12):e28334 (medline /22174790)
CM - Cites: Nat Genet. 2010 Nov;42(11):961-7 (medline /20972439)
CM -Cites: BMC Genomics. 2014 Sep 29;15:823 (medline /25266061)
CM -Cites: Ecotoxicol Environ Saf. 2016 Aug;130:256-62 (medline /27151676)
CM -Cites: Annu Rev Plant Biol. 2008;59:709-33 (medline /18251712)
CM -Cites: Front Plant Sci. 2016 Jun 28;7:956 (medline /27446182)
CM -Cites: New Phytol. 2016 May;210(3):1095-106 (medline /26715032)
CM -Cites: Int J Environ Res Public Health. 2015 Jun 26;12(7):7244-53 (medline
/26132478)
CM - Cites: Theor Appl Genet. 1986 Aug;72(5):587-91 (medline /24248067)
CM - Cites: Science. 2002 Jun 21;296(5576):2145-6 (medline /12077388)
CM - Cites: Bioinformatics. 2007 Oct 1;23(19):2633-5 (medline /17586829)
CM - Cites: Nat Plants. 2015 Dec 21;2(1):15202 (medline /27004129)
CM - Cites: Front Plant Sci. 2016 Jun 15;7:833 (medline /27379126)
CM - Cites: PLoS One. 2016 Aug 01;11(8):e0158906 (medline /27479588)
CM - Cites: Sci Total Environ. 2014 Aug 1;488-489:176-87 (medline /24830930)
CM - Cites: Int J Environ Health Res. 2015;25(4):432-52 (medline /25365079)
CM - Cites: Nat Commun. 2013;4:2832 (medline /24343161)
CM - Cites: Plant Physiol Biochem. 2016 Sep;106:208-17 (medline /27174139)
CM - Cites: New Phytol. 2016 Jul;211(2):658-70 (medline /26918637)
CM - Cites: Chemosphere. 2015 May;127:127-35 (medline /25676498)
CM - Cites: J Exp Bot. 2015 Aug;66(15):4749-57 (medline /26022253)
CM - Cites: Planta. 2016 Mar;243(3):605-22 (medline /26563149)
CM - Cites: Environ Pollut. 2010 May;158(5):1169-81 (medline /19914753)
CM - Cites: Plant J. 2015 Apr;82(2):245-55 (medline /25736370)
CM - Cites: PLoS One. 2011 May 04;6(5):e19379 (medline /21573248)
CM - Cites: Environ Monit Assess. 2016 Sep;188(9):506 (medline /27491949)
CM - Cites: Ecotoxicol Environ Saf. 2011 Jul;74(5):1316-24 (medline /21397946)
CM - Cites: Nat Commun. 2014 Aug 07;5:4617 (medline /25099865)
CM - Cites: J Exp Bot. 2016 Aug;67(15):4639-46 (medline /27340233)
CM - Cites: PLoS One. 2014 Feb 25;9(2):e89685 (medline /24586963)
CM - Cites: Mol Plant. 2017 Mar 6;10 (3):414-426 (medline /27381443)
CM - Cites: Nat Genet. 2016 Oct;48(10 ):1233-41 (medline /27526320)
CM - Cites: J Biol Chem. 2006 Aug 18;281(33):23620-31 (medline /16785233)
CM - Cites: Plant Biotechnol J. 2017 Oct;15(10 ):1250-1263 (medline /28218981)
CM - Cites: Sci Rep. 2016 Feb 16;6:21292 (medline /26880701)
CM - Cites: New Phytol. 2008;177(2):350-5 (medline /17995916)
CM - Cites: PLoS Biol. 2014 Dec 02;12(12):e1002009 (medline /25464340)
DOCNO- medline/29055111

256 - TOXLINE
TI - Occurrence and speciation of arsenic and mercury in estuarine sediments
affected by mining activities (Asturias, northern Spain).
AU - Garcia-Ordiales E
AD - ISYMA Research Group, Mining, Energy and Materials Engineering School,
University of Oviedo, Oviedo, Spain. Electronic address: garciaefren@uniovi.es.
AU - Covelli S
AD - Department of Mathematics and Geosciences, University of Trieste, Trieste,
Italy; Co.N.I.S.Ma. Consorzio Nazionale Interuniversitario per le Scienze del Mare,
Piazzale Flaminio 9, 00196, Rome, Italy.
AU - Rico JM
AD - Department of Organisms and Systems Biology, University of Oviedo, Oviedo,
Spain.
AU - Roque�� N
AD - ISYMA Research Group, Mining, Energy and Materials Engineering School,
University of Oviedo, Oviedo, Spain.
AU - Fontolan G
AD - Department of Mathematics and Geosciences, University of Trieste, Trieste,
Italy; Co.N.I.S.Ma. Consorzio Nazionale Interuniversitario per le Scienze del Mare,
Piazzale Flaminio 9, 00196, Rome, Italy.
AU - Flor-Blanco G
AD - GeoQUO Research Group, Department of Geology, University of Oviedo, Oviedo,
Spain.
AU - Cienfuegos P
AD - ISYMA Research Group, Mining, Energy and Materials Engineering School,
University of Oviedo, Oviedo, Spain.
AU - Loredo J
AD - ISYMA Research Group, Mining, Energy and Materials Engineering School,
University of Oviedo, Oviedo, Spain.
SO - Chemosphere. 2018, May; 198:281-289. [Chemosphere]
AB - Sediments contaminated by Hg and As from two historical mining areas have
been deposited in the Nal�n estuary (Asturias, northern Spain)
since 1850. Total mercury (Hgtotal) concentrations in the sediments range
from 0.20&#8239;&mu;g&#8239;g-1 to 1.33&#8239;&mu;g&#8239;g-1, most of it
in the form of sulphides. Concentrations of methylmercury
(303.20-865.40&#8239;pg&#8239;g-1) are up to two orders of magnitude lower
than the concentration of Hgtotal. Total As concentration (Astotal) is
enriched compared to the background level for the area. The relative
abundance of As(V) on As(III) in the sediments ranges from 97.6% to 100%,
whereas inorganic Hg accounts for more than 99% of the total Hg. The
occurrence of the most toxic species, inorganic As(III) and organic
methylmercury, seem to be related to redox conditions together with the
amounts of sulphur which act as natural barriers which inhibit the
biological and chemical speciation processes. Despite the high amounts of
Hg and As present in the sediments, their transference to the water column
appear to be limited thus converting sediments in an effective sink of
both elements. Special attention should be paid to potential variations of
the environmental conditions which might increase the element mobility and
exchange between sediments and the water column.
KW - Arsenic
KW - Estuary
KW - Mercury
KW - Mining
KW - Sediments
KW - Speciation
RN - 059QF0KO0R
RN - FXS1BY2PGL
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180529
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180203
STAT- MEDLINE
DOCNO- medline/29421740

257 - TOXLINE
TI - Screening for gene-environment (G&times;E) interaction using omics data
from exposed individuals: an application to gene-arsenic interaction.
AU - Argos M
AD - Division of Epidemiology and Biostatistics, University of Illinois at
Chicago, 1603 West Taylor Street, MC 923, Chicago, IL, 60612, USA. argos@uic.edu.
AU - Tong L
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL,
60637, USA.
AU - Roy S
AD - Waterborne Disease Prevention Branch, Division of Foodborne, Waterborne, and
Environmental Diseases, Center for Disease Control and Prevention, Atlanta, GA,
30333, USA.
AU - Sabarinathan M
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL,
60637, USA.
AU - Ahmed A
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Islam MT
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Islam T
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Rakibuz-Zaman M
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Sarwar G
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Shahriar H
AD - UChicago Research Bangladesh, Dhaka, Bangladesh.
AU - Rahman M
AD - Research and Evaluation Division, BRAC, Dhaka, Bangladesh.
AU - Yunus M
AD - International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
AU - Graziano JH
AD - Department of Environmental Health Sciences, Mailman School of Public Health,
Columbia University, New York, NY, 10032, USA.
AU - Jasmine F
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL,
60637, USA.
AU - Kibriya MG
AD - Department of Public Health Sciences, University of Chicago, Chicago, IL,
60637, USA.
AU - Zhou X
AD - Department of Biostatistics, University of Michigan School of Public Health,
Ann Arbor, MI, 48109, USA.
AU - Ahsan H
AD - Department of Medicine, University of Chicago, Chicago, IL, 60637, USA.
AU - Pierce BL
AD - The University of Chicago, 5841 South Maryland Avenue, Room W264, MC2000,
Chicago, IL, 60637, USA. brandonpierce@uchicago.edu.
SO - Mamm Genome. 2018, Feb; 29(1-2):101-111. [Mammalian genome : official
journal of the International Mammalian Genome Society]
AB - Identifying gene-environment interactions is a central challenge in the
quest to understand susceptibility to complex, multi-factorial diseases.
Developing an understanding of how inter-individual variability in
inherited genetic variation alters the effects of environmental exposures
will enhance our knowledge of disease mechanisms and improve our ability
to predict disease and target interventions to high-risk sub-populations.
Limited progress has been made identifying gene-environment interactions
in the epidemiological setting using existing statistical approaches for
genome-wide searches for interaction. In this paper, we describe a novel
two-step approach using omics data to conduct genome-wide searches for
gene-environment interactions. Using existing genome-wide SNP data from a
large Bangladeshi cohort study specifically designed to assess the effect
of arsenic exposure on health, we evaluated gene-arsenic interactions by
first conducting genome-wide searches for SNPs that modify the effect of
arsenic on molecular phenotypes (gene expression and DNA methylation
features). Using this set of SNPs showing evidence of interaction with
arsenic in relation to molecular phenotypes, we then tested SNP-arsenic
interactions in relation to skin lesions, a hallmark characteristic of
arsenic toxicity. With the emergence of additional omics data in the
epidemiologic setting, our approach may have the potential to boost power
for genome-wide interaction research, enabling the identification of
interactions that will enhance our understanding of disease etiology and
our ability to develop interventions targeted at susceptible
sub-populations.
LA - eng
IS - 1432-1777 (Electronic)
PT - Journal Article
TA - Mamm Genome
YR - 2018
DATE- 20180421
CITO- NLM
CS - United States
FJT - Mammalian genome : official journal of the International Mammalian Genome
Society
EDAT- 20180216
STAT- In-Data-Review
CM - Cites: Curr Atheroscler Rep. 2012 Dec;14(6):542-55 (medline /22968315)
CM - Cites: Environ Health Perspect. 2015 Jan;123(1):64-71 (medline /25325195)
CM - Cites: Environ Health Perspect. 2010 Mar;118(3):345-50 (medline /20194069)
CM - Cites: Environ Health Perspect. 2012 May;120(5):623-6 (medline /22336149)
CM - Cites: Epidemiology. 2006 Jul;17(4):459-67 (medline /16755266)
CM - Cites: Toxicol Appl Pharmacol. 2009 Mar 15;235(3):338-50 (medline
/19168087)
CM - Cites: Am J Epidemiol. 2006 Jun 15;163(12):1138-48 (medline /16624965)
CM - Cites: Environ Health Perspect. 2007 Jun;115(6):A296 (medline /17589576)
CM - Cites: Am J Epidemiol. 2017 Oct 1;186(7):778-786 (medline /28978190)
CM - Cites: Am J Epidemiol. 2012 May 1;175(9):962-9 (medline /22491085)
CM - Cites: J Expo Sci Environ Epidemiol. 2006 Mar;16(2):191-205 (medline
/16160703)
CM - Cites: Epigenomics. 2011 Dec;3(6):771-84 (medline /22126295)
CM - Cites: Cancer Res. 2012 Apr 15;72(8):2036-44 (medline /22367214)
CM - Cites: Mutat Res. 2008 Sep-Oct;659(3):293-301 (medline /18638567)
CM - Cites: Environ Health Perspect. 2012 Apr;120(4):494-500 (medline
/22138666)
CM - Cites: Mutat Res Genet Toxicol Environ Mutagen. 2014 Jan 15;760:1-9
(medline /24309507)
CM - Cites: J Natl Cancer Inst. 2011 Aug 17;103(16):1252-63 (medline /21791674)
CM - Cites: Int J Epidemiol. 2013 Dec;42(6):1862-71 (medline /24536095)
CM - Cites: Environ Health Perspect. 2012 Dec;120(12 ):1658-70 (medline
/22889723)
CM - Cites: Eur J Clin Invest. 2013 Jun;43(6):579-88 (medline /23590571)
CM - Cites: Environ Health Perspect. 2006 Nov;114(11):1790-6 (medline
/17107869)
CM - Cites: Am J Epidemiol. 2017 Oct 1;186(7):753-761 (medline /28978193)
CM - Cites: Pharmacogenomics. 2008 Aug;9(8):1113-32 (medline /18681785)
CM - Cites: Sci Total Environ. 2013 Jun 1;454-455:562-77 (medline /23570911)
CM - Cites: Am J Epidemiol. 2005 Dec 1;162(11):1037-49 (medline /16269585)
CM - Cites: Environ Res. 2014 Jul;132:156-67 (medline /24792412)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007
Oct;42(12):1859-67 (medline /17952787)
CM - Cites: Int Arch Occup Environ Health. 1996;68(6):484-94 (medline /8891790)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):243-52 (medline
/15276403)
CM - Cites: BMC Cancer. 2010 Dec 04;10:670 (medline /21129217)
CM - Cites: Genet Epidemiol. 2010 Dec;34(8):816-34 (medline /21058334)
CM - Cites: Environ Health Perspect. 2008 Aug;116(8):1056-62 (medline
/18709164)
CM - Cites: PLoS Genet. 2012;8(2):e1002522 (medline /22383894)
CM - Cites: Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20656-60 (medline
/22143778)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt C):11-465 (medline
/23189751)
CM - Cites: Lancet. 2010 Jul 24;376(9737):252-8 (medline /20646756)
CM - Cites: Genet Epidemiol. 2013 Nov;37(7):643-57 (medline /24123198)
CM - Cites: PLoS Genet. 2014 Dec 04;10(12):e1004818 (medline /25474530)
CM - Cites: Breast Cancer Res. 2010;12(6):R110 (medline /21194473)
CM - Cites: Am J Hum Genet. 2012 Jan 13;90(1):7-24 (medline /22243964)
CM - Cites: Lancet. 2010 Jun 19;375(9732):2143-51 (medline /20605201)
CM - Cites: Environ Health Perspect. 2006 May;114(5):641-8 (medline /16675414)
CM - Cites: PLoS Genet. 2013;9(3):e1003284 (medline /23544014)
CM - Cites: Clin Chim Acta. 1973 Feb 12;43(3):305-10 (medline /4690902)
CM - Cites: Am J Epidemiol. 2017 Oct 1;186(7):762-770 (medline /28978192)
CM - Cites: Nat Genet. 2012 Jun 17;44(7):821-4 (medline /22706312)
CM - Cites: Int Arch Occup Environ Health. 2002 Oct;75(8):576-80 (medline
/12373320)
CM - Cites: Environ Health Perspect. 2012 Jun;120(6):779-89 (medline /22296744)
CM - Cites: Clin Chem. 1991 Sep;37(9):1575-9 (medline /1893592)
CM - Cites: Am J Public Health. 2007 May;97(5):825-31 (medline /17395836)
DOCNO- medline/29453499

258 - TOXLINE
TI - Dietary intake and urinary metals among pregnant women in the Pacific
Northwest.
AU - Osorio-Y��ez C
AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health,
Boston, MA, USA; ISGlobal, Centre for Research in Environmental Epidemiology
(CREAL) Barcelona, Spain. Electronic address: cosorio@hsph.harvard.edu.
AU - Gelaye B
AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health,
Boston, MA, USA.
AU - Enquobahrie DA
AD - Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA;
Department of Epidemiology, University of Washington, Seattle, WA, USA.
AU - Qiu C
AD - Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA.
AU - Williams MA
AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health,
Boston, MA, USA.
SO - Environ Pollut. 2018, May; 236:680-688. [Environmental pollution (Barking,
Essex : 1987)]
AB - Pregnancy is a period when the mother and her offspring are susceptible to
the toxic effects of metals. We investigated associations of intake of
frequently consumed foods with urinary metals concentrations among
pregnant women in the Pacific Northwest. We measured urinary cadmium
(U-Cd), arsenic (U-As) and molybdenum (U-Mo) concentrations from spot
urine samples in early pregnancy (15 weeks of gestation, on average) among
558 women from Seattle and Tacoma, Washington. We assessed
periconceptional dietary intake using a semi-quantitative food frequency
questionnaire (FFQ). We also determined early pregnancy zinc
concentrations in serum. Statistical analyses involved multivariable
linear regression models, adjusted for smoking status, age,
race/ethnicity, multivitamin and supplement use, education, estimated
total energy intake, and gravidity. The geometric mean and range in
&mu;g/g creatinine for U-Cd, U-As and U-Mo were 0.29 (0.1-8.2), 18.95
(3-550), and 72.1 (15-467), respectively. U-Cd was positively associated
with dietary zinc intake (P-value&#8239;=&#8239;0.004) and serum zinc
(P-value < 0.001) while it was negatively associated with coffee intake
(P-value&#8239;=&#8239;0.03). U-As was positively associated with dietary
fish [(Lean fish, fatty fish, shellfish and non-fried fish)
(P-values < 0.01)], selenium (P-value&#8239;=&#8239;0.004), zinc
(P-value&#8239;=&#8239;0.017), vegetables (P-value&#8239;=&#8239;0.004),
and low-fat yogurt (P-value&#8239;=&#8239;0.03). Women who reported higher
intake of dietary magnesium (Mg)(P-value&#8239;=&#8239;0.04), insoluble
fiber (P-value&#8239;=&#8239;0.03), and low-fat yogurt
(P-value&#8239;=&#8239;0.04) had higher U-Mo concentrations. Our study
suggests that vegetables, fish, fiber and yogurt might be significant
dietary sources of metals. Future studies aimed at investigating the risk
of exposure to metals from other various food sources among
reproductive-age and pregnant women are needed.
KW - Arsenic
KW - Cadmium
KW - Maternal diet
KW - Molybdenum
KW - Pregnancy
RN - 00BH33GNGH
RN - 81AH48963U
RN - H6241UJ22B
RN - I38ZP9992A
RN - J41CSQ7QDS
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180608
CI - Copyright &copy; 2018. Published by Elsevier Ltd.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
STAT- MEDLINE
DOCNO- medline/29438954

259 - TOXLINE
TI - Evaluating blood and excrement as bioindicators for metal accumulation in
birds.
AU - Berglund �MM
AD - Department of Ecology and Environmental Science, Ume� University, SE-90187
Ume�, Sweden. Electronic address: asa.berglund@umu.se.
SO - Environ Pollut. 2018, Feb; 233:1198-1206. [Environmental pollution
(Barking, Essex : 1987)]
AB - Birds are widely used to assess metal contamination in the environment and
there are different approaches to determine the exposure level in
individuals, some being destructive (collection of soft tissues) and some
non-destructive (blood, feathers and excrement). The use of blood to
detect internal concentrations of metals is an acknowledged method, but to
what extent blood can predict the concentrations in soft tissues has been
less well evaluated in wild terrestrial birds. The same is true for
excrements. This study compares the non-destructive methods using blood
and excrement with liver sampling, with respect to exposure and
accumulation of the elements arsenic, cadmium, copper, lead and zinc in
nestling pied flycatchers (Ficedula hypoleuca). Blood, liver and excrement
reflected the environmental exposure of non-essential elements and were
independent of nestling sex. There were asymptotic relationships between
the concentration of arsenic, cadmium and lead in liver and blood,
excrement and liver, and excrement and blood, but none for copper or zinc.
Those relationships were generally stronger between liver and blood than
between excrements and internal concentrations. Lead had the strongest
associations for all matrixes. The conclusion is that blood is an
appropriate tool to assess accumulation of arsenic, cadmium and especially
lead, but that blood can underestimate the accumulation at highly
contaminated sites. Excrement can also give an indication of metal
accumulation, but may overestimate internal concentrations at high
exposure, and individual variability makes direct comparisons between
these matrices less appropriate.
KW - Bioindicator
KW - Ecotoxicology
KW - Ficedula hypoleuca
KW - Metal
KW - Passerine
KW - Wildlife
RN - 00BH33GNGH
RN - 789U1901C5
RN - J41CSQ7QDS
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180419
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171016
STAT- MEDLINE
DOCNO- medline/29050729

260 - TOXLINE
TI - Cytotoxic Assessment of Chromium and Arsenic Using Chromosomal Behavior of
Root Meristem in Allium cepa L.
AU - Gupta K
AD - Plant Genetic Unit, Department of Botany, University of Lucknow, Lucknow,
226007, India.
AU - Mishra K
AD - Plant Genetic Unit, Department of Botany, University of Lucknow, Lucknow,
226007, India.
AU - Srivastava S
AD - Institute of Environment and Sustainable Development, Banaras Hindu
University, Varanasi, 221005, India.
AU - Kumar A
AD - Plant Genetic Unit, Department of Botany, University of Lucknow, Lucknow,
226007, India. amit_gene@yahoo.com.
SO - Bull Environ Contam Toxicol. 2018, Jun; 100(6):803-808. [Bulletin of
environmental contamination and toxicology]
AB - A study was performed for phyto-genotoxic assay of chromium (Cr) and
arsenic (As) through Allium cepa. Various concentrations (0, 1, 3, 6 and
12 mg L-1) of Cr and As for 48 and 168 h time points
exposed to A. cepa. The phytotoxic effects of metal(loid) were evident
through inhibited root length and root protein. Metal(loid) toxicity also
lead to genotoxic effects, which included depression of mitotic index and
increased frequency of chromosomes aberrations like break, fragments,
c-metaphase, multipolar arrangements etc. Genotoxic endpoint as
progressive frequency of micronuclei in interphase of root meristem cells
in treated plants was also observed. This genotoxic endpoint revealed
carcinogenic nature of both aforementioned metal(loid). Along with
inhibition in root length and protein content, depression in mitotic index
as well as stimulation of various abnormality in mitotic cell division
indicated that both metal(loid) are hazardous in nature and causing
harmful effect on the environment.
KW - Arsenic
KW - Chromium
KW - Micronuclei
KW - Phyto-genotoxic effects
KW - Plant bioassay
LA - eng
IS - 1432-0800 (Electronic)
PT - Journal Article
TA - Bull Environ Contam Toxicol
YR - 2018
DATE- 20180529
CITO- NLM
CS - United States
FJT - Bulletin of environmental contamination and toxicology
EDAT- 20180427
STAT- In-Process
DOCNO- medline/29704021

261 - TOXLINE
TI - Methodology of spatial risk assessment for arsenic species associated with
sampling and analysis results optimization.
AU - Zhang Y
AD - College of Environmental Science and Engineering, North China Electric Power
University, Beijing 102206, China; Laboratory of Environment Remediation and
Function Material, Suzhou Research Academy of North China Electric Power
University, Suzhou, Jiangsu 215213, China. Electronic address:
zhangym@ncepu.edu.cn.
AU - Wang L
AD - College of Environmental Science and Engineering, North China Electric Power
University, Beijing 102206, China.
AU - Chen J
AD - Suzhou University of Science and Technology, Suzhou 215009, China.
AU - Zhao Y
AD - College of Environmental Science and Engineering, North China Electric Power
University, Beijing 102206, China.
AU - Lai Y
AD - College of Environmental Science and Engineering, North China Electric Power
University, Beijing 102206, China.
AU - Wu P
AD - College of Environmental Science and Engineering, North China Electric Power
University, Beijing 102206, China.
SO - Sci Total Environ. 2018, May 17; 639:8-18. [The Science of the total
environment]
AB - The conventional risk assessment methods may be defective for more
effective health risk assessment due to ignoring heavy metal species and
the accuracy and integrity of sampling and analysis results. Using the
accurate and integral data to quantify the human health effects of metal
species can provide great support for more effective health risk
assessment. This study presents a new methodology to optimize sampling and
analysis results for implementing the spatial human health risk of heavy
metal species in contaminated sites. The method integrated Entropy method
and Inverse Distance to a Power (IDW) for obtaining the effective risk,
and mapping the visual risk distribution of metal species. The results of
its application with ingesting arsenic via oral route on adults showed
that carcinogenic and non-carcinogenic risks of As were influenced by its
species. The risk of HAsO4-2, H3AsO3, H2AsO4-, H2AsO3- and AsS(OH)HS-
exceeded threshold that was significantly harmful to human health in study
area. This method broadened the scope of human health risk assessment and
provided a basis for government policy-making and site remediation.
KW - Arsenic species
KW - Data modification
KW - Risk assessment
KW - Spatial analysis
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180529
CI - Copyright &copy; 2018. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180517
STAT- Publisher
DOCNO- medline/29778685

262 - TOXLINE
TI - Metals in urine in relation to the prevalence of pre-diabetes, diabetes
and atherosclerosis in rural India.
AU - Velmurugan G
AD - Department of Chemistry, DST Unit of Nanoscience and Thematic Unit of
Excellence in Water Research, Indian Institute of Technology Madras, Chennai, Tamil
Nadu, India.
AU - Swaminathan K
AD - KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore,
Tamil Nadu, India.
AU - Veerasekar G
AD - KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore,
Tamil Nadu, India.
AU - Purnell JQ
AD - Department of Medicine, Oregon Health &amp; Science University, Portland,
Oregon, USA.
AU - Mohanraj S
AD - KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore,
Tamil Nadu, India.
AU - Dhivakar M
AD - Department of Chemistry, DST Unit of Nanoscience and Thematic Unit of
Excellence in Water Research, Indian Institute of Technology Madras, Chennai, Tamil
Nadu, India.
AU - Avula AK
AD - Department of Chemistry, DST Unit of Nanoscience and Thematic Unit of
Excellence in Water Research, Indian Institute of Technology Madras, Chennai, Tamil
Nadu, India.
AU - Cherian M
AD - KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore,
Tamil Nadu, India.
AU - Palaniswami NG
AD - KMCH Research Foundation, Kovai Medical Centre and Hospital, Coimbatore,
Tamil Nadu, India.
AU - Alexander T
AD - Department of Medicine, Oregon Health &amp; Science University, Portland,
Oregon, USA.
AU - Pradeep T
AD - Department of Chemistry, DST Unit of Nanoscience and Thematic Unit of
Excellence in Water Research, Indian Institute of Technology Madras, Chennai, Tamil
Nadu, India.
SO - Occup Environ Med. 2018, Apr 19. [Occupational and environmental medicine]
AB - OBJECTIVE: Diabetes and cardiovascular diseases are growing burdens in
rural communities worldwide. We have observed a high prevalence of
diabetes among rural farming communities in India and sought to evaluate
the association of non-traditional risk factors, such as metals, with
diabetes and other cardiometabolic risk factors in this community.
AB - METHODS: Anthropometric measurements, chemistries and carotid intima-media
thickness were determined in 865 participants of the Kovai Medical Center
and Hospital-Nallampatti Non-Communicable Disease Study-I (KMCH-NNCD-I,
2015), a cross-sectional study conducted in a farming village in South
India. Urinary metal levels were determined by inductively couped
plasma-mass spectrometry analysis and corrected to urinary creatinine
level. Statistical analyses were performed to study the association
between urinary metal levels and clinical parameters.
AB - RESULTS: 82.5% of the study population were involved in farming and high
levels of toxic metals were detected in the synthetic fertilisers used in
the study village. The prevalence of pre-diabetes, diabetes and
atherosclerosis was 43.4%, 16.2% and 10.3%, respectively. On logistic
regression analysis, no association of traditional risk factors such as
body mass index, blood pressure and total cholesterol with disease
conditions was observed, but urinary levels of metals such as arsenic,
chromium, aluminium and zinc showed an association with diabetes, while
arsenic and zinc showed an association with pre-diabetes and
atherosclerosis.
AB - CONCLUSIONS: Our data suggest a probable role of metals in the aetiology
of diabetes and cardiovascular diseases in rural communities. Identifying
and eliminating the causes of increased levels of these environmental
chemicals could have a beneficial impact on the burden of non-communicable
diseases in rural population.
COI - Competing interests: None declared.
KW - arsenic
KW - atherosclerosis
KW - cardiometabolic risk factors
KW - diabetes
KW - metals
KW - pre-diabetes
KW - rural health
LA - eng
IS - 1470-7926 (Electronic)
PT - Journal Article
TA - Occup Environ Med
YR - 2018
DATE- 20180420
CI - &copy; Article author(s) (or their employer(s) unless otherwise stated in
the text of the article) 2018. All rights reserved. No commercial use is
permitted unless otherwise expressly granted.
CITO- NLM
CS - England
FJT - Occupational and environmental medicine
EDAT- 20180419
STAT- Publisher
DOCNO- medline/29674487

263 - TOXLINE
TI - Source identification and spatial distribution of arsenic and heavy metals
in agricultural soil around Hunan industrial estate by positive matrix
factorization model, principle components analysis and geo statistical
analysis.
AU - Zhang X
AD - Institute of Food Science and Technology, Chinese Academy of Agriculture
Sciences/ Key Laboratory of Agro-products Quality and Safety Control in Storage and
Transport Process, Ministry of Agriculture, Beijing 100193, PR China.
AU - Wei S
AD - Institute of Food Science and Technology, Chinese Academy of Agriculture
Sciences/ Key Laboratory of Agro-products Quality and Safety Control in Storage and
Transport Process, Ministry of Agriculture, Beijing 100193, PR China.
AU - Sun Q
AD - Institute of Food Science and Technology, Chinese Academy of Agriculture
Sciences/ Key Laboratory of Agro-products Quality and Safety Control in Storage and
Transport Process, Ministry of Agriculture, Beijing 100193, PR China.
AU - Wadood SA
AD - Institute of Food Science and Technology, Chinese Academy of Agriculture
Sciences/ Key Laboratory of Agro-products Quality and Safety Control in Storage and
Transport Process, Ministry of Agriculture, Beijing 100193, PR China.
AU - Guo B
AD - Institute of Food Science and Technology, Chinese Academy of Agriculture
Sciences/ Key Laboratory of Agro-products Quality and Safety Control in Storage and
Transport Process, Ministry of Agriculture, Beijing 100193, PR China. Electronic
address: guoboli2007@126.com.
SO - Ecotoxicol Environ Saf. 2018, Sep 15; 159:354-362. [Ecotoxicology and
environmental safety]
AB - Characterizing the distribution and defining potential sources of arsenic
and heavy metals are the basic preconditions for reducing the
contamination of heavy metals and metalloids. 71 topsoil samples and 61
subsoil samples were collected by grid method to measure the concentration
of cadmium (Cd), arsenic (As), lead (Pb), copper (Cu), zinc (Zn), nickel
(Ni) and chromium (Cr). Principle components analysis (PCA), GIS-based
geo-statistical methods and Positive Matrix Factorization (PMF) were
applied. The results showed that the mean concentrations were
9.59&#8239;mg&#8239;kg-1, 51.28&#8239;mg&#8239;kg-1,
202.07&#8239;mg&#8239;kg-1, 81.32&#8239;mg&#8239;kg-1 and
771.22&#8239;mg&#8239;kg-1 for Cd, As, Pb, Cu and Zn, respectively, higher
than the guideline values of Chinese Environmental Quality Standard for
Soils; while the concentrations of Ni and Cr were very close to
recommended value (50&#8239;mg&#8239;kg-1, 200&#8239;mg&#8239;kg-1), and
some site were higher than guideline values. The soil was polluted by As
and heavy metals in different degree, which had harmful impact on human
health. The results from principle components analysis methods extracted
three components, namely industrial sources (Cd, Zn and Pb), agricultural
sources (As and Cu) and nature sources (Cr and Ni). GIS-based
geo-statistical combined with local conditions further apportioned the
sources of these trace elements. To better identify pollution sources of
As and heavy metals in soil, the PMF was applied. The results of PMF
demonstrated that the enrichment of Zn, Cd and Pb were attributed to
industrial activities and their contribution was 24.9%; As was closely
related to agricultural activities and its contribution was 19.1%; Cr, a
part of Cu and Ni were related to subsoil and their contribution was
30.1%; Cu and Pb came from industry and traffic emission and their
contribution was 25.9%.
KW - Geo-statistical analysis
KW - Heavy metals and metalloids
KW - PCA
KW - PMF
KW - Source identification
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180527
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180521
STAT- In-Process
DOCNO- medline/29778047

264 - TOXLINE
TI - Environmental Exposure of Children to Toxic Trace Elements (Hg, Cr, As) in
an Urban Area of Yucatan, Mexico: Water, Blood, and Urine Levels.
AU - Arcega-Cabrera F
AD - Centro de Investigaci�n y de Estudios Avanzados del IPN-M�rida, km 6 Antigua
carretera a Progreso, Cordemex, 97310, Yucat�n, Mexico. farcega@unam.mx.
AU - Fargher L
AD - Ecolog�a Humana, CINVESTAV-IPN M�rida, Km 6 Antigua Carretera a Progreso,
M�rida, 97310, Yucat�n, Mexico.
AU - Quesadas-Rojas M
AD - Unidad de Qu�mica Sisal, Facultad de Qu�mica, Universidad Nacional Aut�noma
de M�xico, Puerto de Abrigo Sisal, 97355, Yucat�n, Mexico.
AU - Moo-Puc R
AD - Unidad de Investigaci�n M�dica Yucat�n, Unidad M�dica de Alta Especialidad
Hospital de Especialidades Centro M�dico Nacional "Ignacio Garc�a T�llez" M�rida,
Instituto Mexicano del Seguro Social (IMSS), Calle 41 No. 439, Col. Industrial,
M�rida, 97150, Yucat�n, Mexico.
AU - Oceguera-Vargas I
AD - Unidad de Qu�mica Sisal, Facultad de Qu�mica, Universidad Nacional Aut�noma
de M�xico, Puerto de Abrigo Sisal, 97355, Yucat�n, Mexico.
AU - Nore�a-Barroso E
AD - Unidad de Qu�mica Sisal, Facultad de Qu�mica, Universidad Nacional Aut�noma
de M�xico, Puerto de Abrigo Sisal, 97355, Yucat�n, Mexico.
AU - Y��ez-Estrada L
AD - Laboratorio de G�nero, Salud y Ambiente, Facultad de Medicina, Universidad
Aut�noma de San Luis Potos�, San Luis Potos�, 78210, Mexico.
AU - Alvarado J
AD - Facultad de Medicina, Universidad Aut�noma de Yucatan, Av Itzaes 498, M�rida,
97100, Yucat�n, Mexico.
AU - Gonz�lez L
AD - Facultad de Medicina, Universidad Aut�noma de Yucatan, Av Itzaes 498, M�rida,
97100, Yucat�n, Mexico.
AU - P�rez-Herrera N
AD - Unidad Interinstitucional de Investigaci�n Cl�nica y Epidemiol�gica, Facultad
de Medicina, Universidad Aut�noma de Yucat�n, Av. Itzaes No. 498 x 59-A, Colonia
Centro, M�rida, 97000, Yucat�n, Mexico.
AU - P�rez-Medina S
AD - Ecolog�a Humana, CINVESTAV-IPN M�rida, Km 6 Antigua Carretera a Progreso,
M�rida, 97310, Yucat�n, Mexico.
SO - Bull Environ Contam Toxicol. 2018, May; 100(5):620-626. [Bulletin of
environmental contamination and toxicology]
AB - Merida is the largest urban center in the Mexican State of Yucatan. Here
domestic sewage is deposited in poorly built septic tanks and is not
adequately treated. Because of contamination from such waste, water from
the top 20 m of the aquifer is unsuitable for human consumption.
Given this situation and because children are highly vulnerable to
environmental pollution, including exposure to toxic trace elements, this
study focused on evaluating the exposure of children to arsenic (As),
chromium (Cr), and mercury (Hg) in water. It also evaluated the
relationship between the levels of these elements in water and their
concentrations in urine and blood. Among the 33 children monitored in the
study, arsenic surpassed WHO limits for blood in 37% of the cases, which
could result from the ingestion of poultry contaminated with organoarsenic
compounds. In the case of WHO limits for Mercury, 65% of the water samples
analyzed, 28% of urine samples, and 12% of blood samples exceeded them.
Mercury exposure was correlated with biological sex, some lifestyle
factors, and the zone in Merida in which children live. These data suggest
that the levels of some toxic metals in children may be affected by water
source, socioeconomic factors, and individual behavior.
KW - Arsenic
KW - Children
KW - Chromium
KW - Mercury
KW - Merida
KW - Mexico
KW - Water
LA - eng
IS - 1432-0800 (Electronic)
PT - Journal Article
TA - Bull Environ Contam Toxicol
YR - 2018
DATE- 20180417
CITO- NLM
CS - United States
FJT - Bulletin of environmental contamination and toxicology
EDAT- 20180305
STAT- In-Process
DOCNO- medline/29508017

265 - TOXLINE
TI - Nutritional Influences on One-Carbon Metabolism: Effects on Arsenic
Methylation and Toxicity.
AU - Saxena R
AD - These authors contributed equally to this article.
AU - Bozack AK
AD - These authors contributed equally to this article.
AU - Gamble MV
AD - These authors contributed equally to this article.
SO - Annu Rev Nutr. 2018, May 23. [Annual review of nutrition]
AB - Exposure to inorganic arsenic (InAs) via drinking water and/or food is a
considerable worldwide problem. Methylation of InAs generates monomethyl
(MMAsIII+V)- and dimethyl (DMAsIII+V)-arsenical species in a process that
facilitates urinary As elimination; however, MMA is considerably more
toxic than either InAs or DMAs. Emerging evidence suggests that incomplete
methylation of As to DMAs, resulting in increased MMAs, is associated with
increased risk for a host of As-related health outcomes. The biochemical
pathway that provides methyl groups for As methylation, one-carbon
metabolism (OCM), is influenced by folate and other micronutrients,
including choline and betaine. Individuals and species differ widely in
their ability to methylate As. A growing body of research, including
cell-culture, animal-model, and epidemiological studies, has demonstrated
the role of OCM-related micronutrients in As methylation. This review
examines the evidence that nutritional status and nutritional
interventions can influence the metabolism and toxicity of As, with a
primary focus on folate. Expected final online publication date for the
Annual Review of Nutrition Volume 38 is August 21, 2018. Please see
http://www.annualreviews.org/page/journal/pubdates for revised estimates.
LA - eng
IS - 1545-4312 (Electronic)
PT - Journal Article
TA - Annu Rev Nutr
YR - 2018
DATE- 20180525
CITO- NLM
CS - United States
FJT - Annual review of nutrition
EDAT- 20180523
STAT- Publisher
DOCNO- medline/29799766

266 - TOXLINE
TI - Ecotoxicological impact of arsenic on earthworms and collembolans as
affected by attributes of a highly weathered tropical soil.
AU - Alves PRL
AD - Department of Soil Science, College of Agriculture Luiz de Queiroz (ESALQ),
University of S�o Paulo (USP), Ave. P�dua Dias, 11, 13418-900, Piracicaba, S�o
Paulo, Brazil. paulo.roger.lopes@gmail.com.
AU - da Silva EB
AD - Department of Soil Science, College of Agriculture Luiz de Queiroz (ESALQ),
University of S�o Paulo (USP), Ave. P�dua Dias, 11, 13418-900, Piracicaba, S�o
Paulo, Brazil.
AU - Cardoso EJBN
AD - Department of Soil Science, College of Agriculture Luiz de Queiroz (ESALQ),
University of S�o Paulo (USP), Ave. P�dua Dias, 11, 13418-900, Piracicaba, S�o
Paulo, Brazil.
AU - Alleoni LRF
AD - Department of Soil Science, College of Agriculture Luiz de Queiroz (ESALQ),
University of S�o Paulo (USP), Ave. P�dua Dias, 11, 13418-900, Piracicaba, S�o
Paulo, Brazil.
SO - Environ Sci Pollut Res Int. 2018, May; 25(14):13217-13225. [Environmental
science and pollution research international]
AB - High levels of heavy metals in soils may impose serious impacts on
terrestrial organisms. In Brazil, the prevention values for evaluating the
ecological risk of these elements are based only on soil chemical analyses
and/or on data from ecotoxicological assays performed in soils of
temperate regions. However, the attributes of the Brazilian
highly-weathered tropical soils can influence the availability of heavy
metals for soil fauna, resulting in different toxic values. To provide
more accurate ecotoxicological risk values for arsenic (As) in tropical
soils, we assessed the impacts of sodium arsenate (Na2HAsO4&middot;7H2O)
on the reproduction of earthworms (Eisenia andrei) and collembolans
(Folsomia candida), as well as on As bioaccumulation and growth (weight
loss) of E. andrei in a tropical artificial soil (TAS) and in an Oxisol.
In TAS, As doses reduced the reproduction of the species and promoted
weight loss of earthworms. On the other hand, the reproductions of the
species as well as the earthworm growth were not altered by As in the
Oxisol. The effective concentrations that reduce the reproduction of E.
andrei and F. candida by 50 % (EC50) obtained in TAS (22.7 and
26.1 mg of As kg-1 of dry soil, respectively) were lower than
those in the Oxisol ( > 135 mg kg-1, for both species).
Although there was As bioaccumulation in earthworms in both soils, the
internal concentrations in the earthworms were much higher in the
oligochaetes exposed to arsenic in TAS. All these differences were
attributed to the higher availability of As in the TAS, compared to the
Oxisol, which increased the exposure of the species to the metal. The
lower availability in the Oxisol was related to higher contents of type
1:1 silicate minerals and Fe and Al oxides and hydroxides, which strongly
bind to As. These results highlight the importance of using tropical soils
of humid regions to derive the Brazilian ecological risk prevention values
for heavy metals, since the toxicity values are specific for these soils.
KW - Bioaccumulation
KW - Collembolans
KW - Earthworms
KW - Ecotoxicity
KW - Heavy metal
KW - Keywords
KW - Prevention values
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180525
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20160513
STAT- In-Process
CM - Cites: Environ Toxicol Pharmacol. 2015 Nov;40(3):1005-14 (medline
/26606645)
CM - Cites: Integr Environ Assess Manag. 2014 Jul;10(3):346-57 (medline
/24470189)
CM - Cites: Environ Pollut. 2004 Oct;131(3):495-504 (medline /15261413)
CM - Cites: Environ Sci Pollut Res Int. 2013 Dec;20(12):8326-33 (medline
/24026203)
CM - Cites: Ecotoxicol Environ Saf. 2006 Jun;64(2):115-21 (medline /16040122)
CM - Cites: Environ Sci Pollut Res Int. 2015 Oct;22(19):15016-28 (medline
/26002360)
CM - Cites: Environ Toxicol Pharmacol. 2015 Nov;40(3):828-46 (medline
/26476885)
CM - Cites: Chemosphere. 2009 Sep;76(10):1410-5 (medline /19577793)
CM - Cites: J Hazard Mater. 2010 Aug 15;180(1-3):241-6 (medline /20444546)
CM - Cites: J Environ Qual. 2004 Nov-Dec;33(6):2049-55 (medline /15537927)
CM - Cites: Ecotoxicol Environ Saf. 2014 Jul;105:65-71 (medline /24785712)
CM - Cites: Environ Pollut. 2008 May;153(2):450-6 (medline /17889975)
CM - Cites: Ecotoxicol Environ Saf. 1999 Nov;44(3):294-310 (medline /10581124)
CM - Cites: Sci Total Environ. 2015 Sep 1;526:222-32 (medline /25933292)
CM - Cites: Bull Environ Contam Toxicol. 2002 May;68(5):760-5 (medline
/12068945)
CM - Cites: Chemosphere. 2009 Dec;77(11):1526-33 (medline /19850318)
CM - Cites: Ecotoxicol Environ Saf. 2015 Dec;122:91-7 (medline /26218553)
CM - Cites: Environ Toxicol Chem. 2005 Jul;24(7):1716-20 (medline /16050588)
CM - Cites: Environ Toxicol Chem. 2008 Dec;27(12):2488-95 (medline /18620473)
CM - Cites: Environ Pollut. 2003;124(3):361-73 (medline /12758017)
CM - Cites: Sci Total Environ. 2015 Sep 15;527-528:552-60 (medline /26006052)
CM - Cites: Chemosphere. 2013 Mar;90(11):2674-82 (medline /23261124)
CM - Cites: Ecotoxicology. 2014 Sep;23 (7):1195-209 (medline /24875255)
DOCNO- medline/27178288

267 - TOXLINE
TI - The occurrences of heavy metals in farmland soils and their propagation
into paddy plants.
AU - Rahman MS
AD - Department of Genetic Engineering and Biotechnology, Jessore University of
Science and Technology, Jessore, 7408, Bangladesh.
AU - Biswas PK
AD - Department of Genetic Engineering and Biotechnology, Jessore University of
Science and Technology, Jessore, 7408, Bangladesh.
AU - Al Hasan SM
AD - Department of Public Health, Kagawa University, Takamatsu, Kagawa, Japan.
AU - Rahman MM
AD - Department of Environmental Science and Technology, Jessore University of
Science Technology, Jessore, 7408, Bangladesh.
AU - Lee SH
AD - Departments of Environmental Science, Keimyung University, 1095 Dalgubeol-
Daero, Daegu, 42601, South Korea.
AU - Kim KH
AD - Department of Civil and Environmental Engineering, Hanyang University, 222
Wangsimni-Ro, Seoul, 04763, Republic of Korea. kkim61@hanyang.ac.kr.
AU - Rahman SM
AD - Department of Genetic Engineering and Biotechnology, Jessore University of
Science and Technology, Jessore, 7408, Bangladesh. mizanshaikh@yahoo.com.
AU - Islam MR
AD - Department of Biotechnology and Genetic Engineering, Islamic University,
Kushtia, 7003, Bangladesh. rezwaniu@gmail.com.
SO - Environ Monit Assess. 2018, Mar 08; 190(4):201. [Environmental monitoring
and assessment]
AB - In this research, heavy metal accumulation pattern was investigated using
the data measured from the soil, paddy plants, and irrigation water
samples in Jessore district in Bangladesh with the aid of principal
component analysis. A total of 28 samples representing farmland soil and
irrigation water along with paddy plant were collected from 28 locations
in the Jessore district in November 2016. In agricultural soil, arsenic
(As) and nickel (Ni) were found 2.78 and 1.11 times more concentrated than
their background values. In addition, 89% of the sample sites exhibited
enhanced As concentrations relative to the background value. Principal
component analysis (PCA) of soil data showed strong homogeneity in many
species (e.g., Ni, Cu, Fe, and As) to reflect intense agricultural
activities. In contrast, Pb showed no such homogeneity in soil
accumulation pattern. In plant samples, Cu, Fe, and As were strongly
correlated and homologous. This homology of pollution was in agreement
with the pollution homology in the agricultural soil in which the plants
were grown. In irrigation water, Cu and Ni were homologous. Observation of
spatial distribution and other variables indicated that the accumulation
of any particular metal in paddy plants was correlated with its content in
soil and irrigation water, which was influenced by the soil organic
matter, soil/water pH, and other metals present in that environment.
KW - Arsenic
KW - Heavy metals
KW - PCA (principal component analysis)
KW - Spatial distribution
KW - Statistical modeling
RN - 2P299V784P
RN - 789U1901C5
RN - 7OV03QG267
RN - E1UOL152H7
RN - N712M78A8G
LA - eng
IS - 1573-2959 (Electronic)
PT - Journal Article
TA - Environ Monit Assess
YR - 2018
DATE- 20180614
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Environmental monitoring and assessment
EDAT- 20180308
STAT- MEDLINE
CM - Cites: PLoS One. 2015 Feb 06;10(2):e0118082 (medline /25658749)
CM - Cites: ScientificWorldJournal. 2014;2014:517020 (medline /24892058)
CM - Cites: Environ Pollut. 2008 Apr;152(3):746-9 (medline /18339463)
CM - Cites: Sci Total Environ. 2014 Jan 15;468-469:843-53 (medline /24076505)
CM - Cites: Environ Pollut. 2011 Jan;159(1):84-91 (medline /20952112)
CM - Cites: Psychometrika. 1965 Jun;30:179-85 (medline /14306381)
CM - Cites: Environ Sci Technol. 2008 Aug 1;42(15):5574-9 (medline /18754478)
CM - Cites: J Trace Elem Med Biol. 2015;31:237-48 (medline /25660323)
CM - Cites: Bull World Health Organ. 2000;78(9):1093-103 (medline /11019458)
CM - Cites: Lancet. 2016 Nov 12;388(10058):2336-2337 (medline /27845082)
CM - Cites: New Phytol. 2009 Mar;181(4):777-94 (medline /19207683)
CM - Cites: Environ Monit Assess. 2010 Jan;160(1-4):83-9 (medline /19058018)
CM - Cites: J Inorg Biochem. 2002 Jul 25;91(1):9-18 (medline /12121757)
CM - Cites: Toxicol Appl Pharmacol. 2005 Jan 15;202(2):199-211 (medline
/15629195)
CM - Cites: Environ Sci Technol. 2003 Jan 15;37(2):229-34 (medline /12564892)
CM - Cites: J Hazard Mater. 2010 Sep 15;181(1-3):778-87 (medline /20561748)
CM - Cites: Sci Total Environ. 2003 Jun 1;308(1-3):83-96 (medline /12738203)
CM - Cites: Multivariate Behav Res. 1977 Jan 1;12(1):43-7 (medline /26804143)
CM - Cites: Chemosphere. 2013 Jul;92(5):517-23 (medline /23608467)
CM - Cites: J Health Popul Nutr. 2006 Sep;24(3):305-16 (medline /17366772)
CM - Cites: Environ Monit Assess. 2003 Jun;85(2):157-73 (medline /12828350)
CM - Cites: Comp Hepatol. 2003 Apr 3;2(1):5 (medline /12769823)
CM - Cites: Environ Int. 2016 Jan;86:119-25 (medline /26580026)
CM - Cites: Toxicol In Vitro. 2011 Mar;25(2):454-61 (medline /21111804)
CM - Cites: Environ Sci Technol. 2011 Jul 15;45(14):6080-7 (medline /21692537)
CM - Cites: Environ Health Perspect. 2006 Dec;114(12):1826-31 (medline
/17185270)
CM - Cites: Environ Int. 2004 May;30(3):383-7 (medline /14987870)
CM - Cites: Neuropathol Appl Neurobiol. 2016 Apr;42(3):220-41 (medline
/25870938)
CM - Cites: Sci Total Environ. 2013 Feb 15;445-446:48-56 (medline /23314122)
DOCNO- medline/29520494

268 - TOXLINE
TI - In vitro assessment of arsenic mobility in historical mine waste dust
using simulated lung fluid.
AU - Martin R
AD - Faculty of Science and Technology, Federation University Australia, Mount
Helen, VIC, Australia. r.martin@federation.edu.au.
AU - Dowling K
AD - Faculty of Science and Technology, Federation University Australia, Mount
Helen, VIC, Australia.
AU - Nankervis S
AD - Faculty of Science and Technology, Federation University Australia, Mount
Helen, VIC, Australia.
AU - Pearce D
AD - Melbourne School of Population and Global Health, Faculty of Medicine,
Dentistry &amp; Health Sciences, University of Melbourne, Melbourne, Victoria,
Australia.
AU - Florentine S
AD - Faculty of Science and Technology, Federation University Australia, Mount
Helen, VIC, Australia.
AU - McKnight S
AD - Faculty of Science and Technology, Federation University Australia, Mount
Helen, VIC, Australia.
SO - Environ Geochem Health. 2018, Jun; 40(3):1037-1049. [Environmental
geochemistry and health]
AB - Exposure studies have linked arsenic (As) ingestion with disease in
mining-affected populations; however, inhalation of mine waste dust as a
pathway for pulmonary toxicity and systemic absorption has received
limited attention. A biologically relevant extractant was used to assess
the 24-h lung bioaccessibility of As in dust isolated from four distinct
types of historical gold mine wastes common to regional Victoria,
Australia. Mine waste particles less than 20 &micro;m in size (PM20)
were incubated in a simulated lung fluid containing a major surface-active
component found in mammalian lungs, dipalmitoylphosphatidylcholine. The
supernatants were extracted, and their As contents measured after 1, 2, 4,
8 and 24 h. The resultant As solubility profiles show rapid
dissolution followed by a more modest increasing trend, with between 75
and 82% of the total 24-h bioaccessible As released within the first
8 h. These profiles are consistent with the solubility profile of
scorodite, a secondary As-bearing phase detected by X-ray diffraction in
one of the investigated waste materials. Compared with similar studies,
the cumulative As concentrations released at the 24-h time point were
extremely low (range
297 &plusmn; 6-3983 &plusmn; 396 &micro;g L-1),
representing between 0.020 &plusmn; 0.002 and
0.036 &plusmn; 0.003% of the total As in the PM20.
KW - Arsenic
KW - Dust
KW - Lung bioaccessibility
KW - Mine waste
KW - Scorodite
KW - Simulated lung fluid
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180525
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20170512
STAT- In-Process
CM - Cites: Environ Res. 1994 Nov;67(2):183-95 (medline /7982393)
CM - Cites: J Environ Monit. 2011 Jan;13(1):128-36 (medline /20981386)
CM - Cites: Environ Geochem Health. 2009 Apr;31 Suppl 1:85-92 (medline
/19224377)
CM - Cites: J Environ Monit. 2012 Jul;14(7):1798-813 (medline /22718027)
CM - Cites: Environ Pollut. 2013 Sep;180:372-5 (medline /23725856)
CM - Cites: J Hazard Mater. 2014 Sep 15;280:619-26 (medline /25222928)
CM - Cites: Ecotoxicol Environ Saf. 2014 Apr;102:84-92 (medline /24580826)
CM - Cites: Ecotoxicol Environ Saf. 2003 Sep;56(1):164-73 (medline /12915149)
CM - Cites: J Epidemiol Community Health. 2008 May;62(5):442-7 (medline
/18413458)
CM - Cites: Toxicol Sci. 2011 May;121(1):191-206 (medline /21357385)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Jul
15;42(9):1223-31 (medline /17654142)
CM - Cites: Anal Chim Acta. 2013 Apr 24;774:11-25 (medline /23567112)
CM - Cites: Am J Respir Cell Mol Biol. 1997 Jul;17(1):41-50 (medline /9224208)
CM - Cites: Anal Chim Acta. 2014 Dec 10;852:97-104 (medline /25441885)
CM - Cites: Int J Pharm. 2003 Apr 14;255(1-2):175-87 (medline /12672613)
CM - Cites: Environ Geochem Health. 2016 Oct;38(5):1097-114 (medline /26537592)
CM - Cites: Sci Total Environ. 2012 Sep 1;433:58-73 (medline /22766428)
CM - Cites: Biochem Biophys Res Commun. 2011 Oct 28;414(3):533-8 (medline
/21971544)
CM - Cites: Environ Geochem Health. 2015 Oct;37(5):875-89 (medline /26254887)
CM - Cites: Toxicol Appl Pharmacol. 1999 May 15;157(1):43-50 (medline
/10329506)
CM - Cites: J Environ Monit. 2011 Mar;13(3):621-30 (medline /21249261)
CM - Cites: Anal Bioanal Chem. 2011 Nov;401(9):2733-45 (medline /21837467)
CM - Cites: Toxicol In Vitro. 2007 Dec;21(8):1603-9 (medline /17716856)
CM - Cites: Environ Geochem Health. 2017 Jun;39(3):549-563 (medline /27146864)
CM - Cites: Int J Pharm. 2009 Dec 1;382(1-2):15-22 (medline /19665533)
CM - Cites: Environ Sci Technol. 2012 Jun 5;46(11):6252-60 (medline /22606949)
CM - Cites: AAPS PharmSciTech. 2012 Sep;13(3):978-89 (medline /22798037)
CM - Cites: Oncol Rep. 2012 Aug;28(2):749-57 (medline /22684917)
CM - Cites: J Hazard Mater. 2010 Sep 15;181(1-3):526-34 (medline /20538409)
CM - Cites: Chem Soc Rev. 2012 Oct 7;41(19):6606-30 (medline /22660420)
CM - Cites: Thorax. 1990 Nov;45(11):825-30 (medline /2256008)
CM - Cites: J Hazard Mater. 2013 Nov 15;262:1004-13 (medline /23428178)
CM - Cites: Sci Total Environ. 2014 May 1;479-480:117-24 (medline /24561290)
CM - Cites: Environ Sci Technol. 2010 Apr 1;44(7):2667-74 (medline /20218545)
CM - Cites: Mutat Res Genet Toxicol Environ Mutagen. 2014 Jan 15;760:33-41
(medline /24291234)
CM - Cites: PLoS One. 2012;7(11):e46793 (medline /23152752)
CM - Cites: Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 (medline
/11312654)
CM - Cites: Ecotoxicol Environ Saf. 2008 Nov;71(3):722-30 (medline /18206235)
CM - Cites: Sci Total Environ. 2011 Sep 1;409(19):4016-30 (medline /21703664)
CM - Cites: Anal Chim Acta. 2015 Jun 2;877:9-18 (medline /26002206)
CM - Cites: Sci Total Environ. 2000 Apr 17;249(1-3):171-221 (medline /10813455)
DOCNO- medline/28497229

269 - TOXLINE
TI - Arsenic sorption on zero-valent iron-biochar complexes.
AU - Bakshi S
AD - Department of Environmental Sciences, The Connecticut Agricultural Experiment
Station, New Haven, CT 06511, USA. Electronic address: santanubakshi@gmail.com.
AU - Banik C
AD - Department of Agronomy, Iowa State University, Ames, IA 50011, USA.
AU - Rathke SJ
AD - Department of Soil, Water and Environmental Sciences, University of Arizona,
Tucson, AZ 85721, USA.
AU - Laird DA
AD - Department of Agronomy, Iowa State University, Ames, IA 50011, USA.
SO - Water Res. 2018, 06 15; 137:153-163. [Water research]
AB - Arsenic (As) is toxic to human and is often found in drinking water in
India and Bangladesh, due to the natural abundance of arsenides ores.
Different removal procedures such as precipitation, sorption, ion exchange
and membrane separation have been employed for removal of As from
contaminated drinking water (CDW), however, there is a critical need for
low-cost economically viable biochar modification methods which can
enhance As sorption. Here we studied the effectiveness of zero-valent iron
(ZVI)-biochar complexes produced by high temperature pyrolysis of biomass
and magnetite for removing As5+ from CDW. Batch equilibration and column
leaching studies show that ZVI-biochar complexes are effective for
removing As5+ from CDW for the studied pH range (pH &sim;7-7.5) and in the
presence of competing ions. XPS As 3d analysis of ZVI-biochar complexes
exposed to As5+ in the batch and column studies show primarily As3+,
indicating simultaneous oxidation of Fe&deg; to Fe3+ and reduction of As5+
to As3+. SEM-EDS and XRD analyses show isomorphous substitution of As3+
for Fe3+ in neo-formed &alpha;/&gamma;-FeOOH on biochar surfaces, which is
attribute to co-precipitation. This study also demonstrates the efficacy
of pyrolyzing biomass with low-cost iron ores at 900&#8239;&deg;C to
rapidly produce ZVI-biochar complexes, which have potential to be used for
treatment of As CDW.
KW - *Arsenic
KW - *Biochar
KW - *Co-precipitation
KW - *Contaminated drinking water
KW - *Pyrolysis
KW - *Zero valent iron
LA - eng
IS - 1879-2448 (Electronic)
PT - Journal Article
PT - Research Support, U.S. Gov't, Non-P.H.S.
TA - Water Res
YR - 2018
DATE- 20180410
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Water research
EDAT- 20180309
STAT- In-Process
DOCNO- medline/29554531

270 - TOXLINE
TI - Efficient catalytic As(III) oxidation on the surface of ferrihydrite in
the presence of aqueous Mn(II).
AU - Lan S
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River) Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan 430070, China.
AU - Ying H
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River) Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan 430070, China.
AU - Wang X
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River) Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan 430070, China.
AU - Liu F
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River) Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan 430070, China.
AU - Tan W
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River) Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan 430070, China.
AU - Huang Q
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River) Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan 430070, China.
AU - Zhang J
AD - Beijing Synchrotron Radiation Facility, Institute of High Energy Physics,
Chinese Academy of Sciences, Beijing 100039, China.
AU - Feng X
AD - Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of
Yangtse River) Ministry of Agriculture, College of Resources and Environment,
Huazhong Agricultural University, Wuhan 430070, China. Electronic address:
fxh73@mail.hzau.edu.cn.
SO - Water Res. 2018, 01 01; 128:92-101. [Water research]
AB - Arsenic is a carcinogenic element that exists primarily as arsenate
[As(V)] and arsenite [As(III)] in the nature environment, with As(III)
being more toxic and mobile of the two species. In addition, ferrihydrite,
which is widely distributed in soils and aquatic environments, can
catalyze the oxidation of Mn(II) and accelerate the formation of
high-valence Mn, which can significantly influence the speciation,
toxicity, and mobility of As when these species co-exist. In this context,
we herein explored the mechanism of As(III) oxidation in the presence of
ferrihydrite and Mn(II) using a kinetic approach combined with multiple
spectroscopic techniques, including X-ray absorption near edge
spectroscopy, in situ horizontal attenuated total-reflectance Fourier
transform infrared spectroscopy, and in situ quick scanning X-ray
absorption spectroscopy. Our results indicate that efficient As(III)
oxidation by dissolved O2 occurs on the surface of ferrihydrite in the
presence of aqueous Mn(II). Compared with As(III) oxidation in the
presence of ferrihydrite and Mn oxides (i.e., Mn oxides/hydroxides), the
degree of As(III) oxidation in the ferrihydrite-Mn(II) system was
significantly higher, and the majority of generated As(V) was adsorbed on
the mineral (i.e., ferrihydrite) surface. Furthermore, As(III) oxidation
was enhanced upon increasing both the molar ratio of Mn(II)/As(III) and
the solution pH. The greater As(III) oxidation by O2 in the
ferrihydrite-Mn(II) system was mainly attributed to the formation of a
strong oxidant of the instantaneous intermediate Mn(III) species via
Mn(II) oxidation under catalysis by the ferrihydrite surface. Moreover,
As(III) oxidation occurred mainly on the ferrihydrite surface and was
accompanied by the regeneration of Mn(II), thereby rendering it
recyclable. These results therefore provide new insights into the
mechanism of As(III) oxidation on the surfaces of Fe oxides (i.e., Fe
oxides/hydroxides) in the presence of aqueous Mn(II) as well as the new
details regarding the electron transfer mechanisms between the
As(III)-Mn(II, III)-O2 species at the ferrihydrite surface, and could lead
to novel approaches for As(III) contaminant remediation in the
environment.
KW - *As(III) oxidation
KW - *As(V) adsorption
KW - *Catalytic oxidation
KW - *Ferrihydrite
KW - *Mn(II) oxidation
KW - *Mn(III) intermediate
LA - eng
IS - 1879-2448 (Electronic)
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
TA - Water Res
YR - 2018
DATE- 20180409
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Water research
EDAT- 20171023
STAT- In-Process
DOCNO- medline/29091808

271 - TOXLINE
TI - Arsenic and Other Elemental Concentrations in Mushrooms from Bangladesh:
Health Risks.
AU - Rashid MH
AD - Soil Science Division, Bangladesh Agricultural Research Institution (BARI),
Joydebpur, Gazipur 1701, Bangladesh. mdharunur.rashid@uon.edu.au.
AU - Rahman MM
AD - Cooperative Research Centre for Contamination Assessment and Remediation of
the Environment (CRC-CARE), Callaghan, NSW 2308, Australia.
mahmud.rahman@newcastle.edu.au.
AU - Correll R
AD - Rho Environmetrics, Highgate, SA 5063, Australia.
rho.environmetrics@bigpond.com.
AU - Naidu R
AD - Cooperative Research Centre for Contamination Assessment and Remediation of
the Environment (CRC-CARE), Callaghan, NSW 2308, Australia.
ravi.naidu@newcastle.edu.au.
SO - Int J Environ Res Public Health. 2018, May 04. [International journal of
environmental research and public health]
AB - Mushroom cultivation has been increasing rapidly in Bangladesh. Arsenic
(As) toxicity is widespread in the world and Bangladesh faces the greatest
havoc due to this calamity. Rice is the staple food in Bangladesh and
among all the crops grown, it is considered to be the main cause of As
poisoning to its population after drinking water. Consequently, rice
straw, an important growing medium of mushrooms in Bangladesh, is known to
have high As content. The objective of this study was, therefore, to
determine the concentrations of As in mushrooms cultivated in Bangladesh
and to assess the health risk as well. It also considered other elements,
including Cd, Cr, Co, Cu, Pb, Mn, Hg, Ni, and Zn concentrations in
mushrooms from Bangladesh. The mean concentrations (mg/kg) of As, Cd, Cr,
Co, Cu, Pb, Mn, Hg, Ni, and Zn in mushrooms were 0.51, 0.38, 0.28, 0.01,
13.7, 0.31, 11.7, 0.12, 0.28, and 53.5, respectively. Based on the dietary
intake of mushrooms, the weekly intakes of As, Cd, Cr, Co, Cu, Pb, Mn, Hg,
Ni, and Zn from mushrooms for adults were 0.0042, 0.0030, 0.0024, 0.0001,
0.1125, 0.0019, 0.1116, 0.0011, 0.0023, and 0.4734 mg, respectively. Due
to the low concentrations of As and other trace elements observed in
mushrooms from Bangladesh, as well as relatively lower consumption of this
food in people&amp;rsquo;s diet, it can be inferred that consumption of
the species of mushrooms analysed will cause no toxicological risk.
KW - arsenic
KW - daily intake
KW - health risk
KW - heavy metals
KW - mushroom
LA - eng
IS - 1660-4601 (Electronic)
PT - Journal Article
TA - Int J Environ Res Public Health
YR - 2018
DATE- 20180608
CITO- NLM
CS - Switzerland
FJT - International journal of environmental research and public health
EDAT- 20180504
STAT- In-Data-Review
CM - Cites: Environ Int. 2004 Aug;30(6):785-91 (medline /15120196)
CM - Cites: J Environ Manage. 2011 Mar;92(3):554-62 (medline /20937547)
CM - Cites: Environ Sci Technol. 2007 Oct 15;41(20):6947-54 (medline /17993133)
CM - Cites: Environ Health Perspect. 2009 Mar;117(3):410-6 (medline /19337516)
CM - Cites: Appl Microbiol Biotechnol. 2010 Feb;85(5):1321-37 (medline
/19956947)
CM - Cites: Am J Bot. 2011 Mar;98(3):426-38 (medline /21613136)
CM - Cites: Appl Microbiol Biotechnol. 2013 Jan;97(2):477-501 (medline
/23179616)
CM - Cites: Food Chem. 2014 Mar 15;147:147-51 (medline /24206698)
CM - Cites: J Environ Public Health. 2012;2012:460508 (medline /22235210)
CM - Cites: J Environ Sci Health B. 2014;49(12):929-37 (medline /25310808)
CM - Cites: PLoS One. 2013 Aug 26;8(8):e72038 (medline /23991034)
CM - Cites: Food Chem Toxicol. 2014 Nov;73:44-50 (medline /25128776)
CM - Cites: Biol Trace Elem Res. 2005 Sep;106(3):265-77 (medline /16141474)
CM - Cites: Environ Geochem Health. 2009 Apr;31 Suppl 1:179-87 (medline
/19142738)
CM - Cites: J Hazard Mater. 2013 Nov 15;262:1056-63 (medline /22939573)
CM - Cites: Food Chem. 2018 Mar 1;242:225-231 (medline /29037683)
CM - Cites: Environ Pollut. 2012 Jun;165:124-32 (medline /22445920)
CM - Cites: Sci Total Environ. 1988 Oct 15;76(2-3):117-28 (medline /3238419)
CM - Cites: Pak J Biol Sci. 2013 Apr 1;16(7):332-8 (medline /24498800)
CM - Cites: Water Res. 2010 Nov;44(19):5789-802 (medline /20684969)
CM - Cites: Bull Environ Contam Toxicol. 2011 Sep;87(3):276-81 (medline
/21735274)
CM - Cites: Sci Total Environ. 2002 Dec 2;300(1-3):167-77 (medline /12685480)
CM - Cites: Food Chem. 2016 Mar 1;194:849-56 (medline /26471627)
CM - Cites: Sci Total Environ. 1996 Jan 5;177(1-3):251-8 (medline /8584916)
CM - Cites: Environ Sci Technol. 2002 Mar 1;36(5):962-8 (medline /11918027)
CM - Cites: Int J Microbiol. 2015;2015:376387 (medline /25685150)
DOCNO- medline/29734714

272 - TOXLINE
TI - Environmental Risks of Nano Zerovalent Iron for Arsenate Remediation:
Impacts on Cytosolic Levels of Inorganic Phosphate and MgATP2- in
Arabidopsis thaliana.
AU - Zhang W
AD - Department of Civil and Environmental Engineering , The Hong Kong University
of Science and Technology , Clear Water Bay , Hong Kong , China.
AU - Lo IMC
AD - Department of Civil and Environmental Engineering , The Hong Kong University
of Science and Technology , Clear Water Bay , Hong Kong , China.
AU - Hu L
AD - State Key Laboratory of Hydro-Science and Engineering, Department of
Hydraulic Engineering , Tsinghua University , Beijing 100084 , China.
AU - Voon CP
AD - School of Biological Sciences , the University of Hong Kong , Pokfulam , Hong
Kong , China.
AU - Lim BL
AD - School of Biological Sciences , the University of Hong Kong , Pokfulam , Hong
Kong , China.
AU - Versaw WK
AD - Department of Biology , Texas A&amp;M University , College Station , Texas
77843 , United States.
SO - Environ Sci Technol. 2018, Apr 03; 52(7):4385-4392. [Environmental science
& technology]
AB - The use of nano zerovalent iron (nZVI) for arsenate (As(V)) remediation
has proven effective, but full-scale injection of nZVI into the subsurface
has aroused serious concerns for associated environmental risks. This
study evaluated the efficacy of nZVI treatment for arsenate remediation
and its potential hazards to plants using Arabidopsis thaliana grown in a
hydroponic system. Biosensors for inorganic phosphate (Pi) and MgATP2-
were used to monitor in vivo Pi and MgATP2- levels in plant cells. The
results showed that nZVI could remove As(V) from growth media, decrease As
uptake by plants, and mitigate As(V) toxicity to plants. However, excess
nZVI could cause Pi starvation in plants leading to detrimental effects on
plant growth. Due to the competitive adsorption of As(V) and Pi on nZVI,
removing As(V) via nZVI treatment at an upstream site could relieve
downstream plants from As(V) toxicity and Pi deprivation, in which case
100 mg/L of nZVI was the optimal dosage for remediation of As(V) at a
concentration around 16.13 mg/L.
LA - eng
IS - 1520-5851 (Electronic)
PT - Journal Article
TA - Environ Sci Technol
YR - 2018
DATE- 20180403
CITO- NLM
CS - United States
FJT - Environmental science &amp; technology
EDAT- 20180323
STAT- In-Data-Review
DOCNO- medline/29554421

273 - TOXLINE
TI - Microscopic insight into precipitation and adsorption of As(V) species by
Fe-based materials in aqueous phase.
AU - Yan D
AD - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of
Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's
Republic of China.
AU - Li HJ
AD - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of
Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's
Republic of China.
AU - Cai HQ
AD - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of
Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's
Republic of China.
AU - Wang M
AD - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of
Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's
Republic of China.
AU - Wang CC
AD - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of
Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's
Republic of China.
AU - Yi HB
AD - State Key Laboratory of Chemo/Biosensing and Chemometrics, College of
Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People's
Republic of China. Electronic address: hbyi@hnu.edu.cn.
AU - Min XB
AD - Chinese National Engineering Research Center for Control &amp; Treatment of
Heavy Metal Pollution, School of Metallurgy and Environment, Central South
University, Changsha 410083, China. Electronic address: mxbcsu@163.com.
SO - Chemosphere. 2018, Mar; 194:117-124. [Chemosphere]
AB - The mechanism of As(V) removal from the drinking water and industrial
effluents by iron materials remains unclear at the molecular level. In
this work, the association of Fe-based materials with As(V) species was
explored using density functional theory and ab initio calculations.
Solvent separated ion pair structures of [FeH2AsO4]2+aq species may be
dominant in an acidic solution of FeAs complex. The association trend of
H2AsO4- species by Fe3+aq is found to be quite weak in the aqueous
solution, which may be attributed to the strong hydration of Fe3+aq and
[FeH2AsO4]2+ species. However, the association of H2AsO4- species by
colloidal clusters is quite strong, due to the weakened hydration of
Fe(III) in colloidal structures. The hydrophobicity of Fe-based materials
may be one of the key factors for their As(V) removal efficiency in an
aqueous phase. When the number of OH- coordinated with Fe(III) increases,
the association trend of As(V) by colloidal ferric hydroxides weakens
accordingly. This study provides insights into understanding the
coprecipitation and adsorption mechanisms of arsenate removal and
revealing the high efficiency of arsenate removal by colloidal ferric
hydroxides or iron salts under moderate pH conditions.
KW - Adsorption
KW - Arsenate
KW - Density functional theory
KW - Hydrophobic
KW - Iron
KW - Precipitation
RN - 2UA751211N
RN - N712M78A8G
RN - N7CIZ75ZPN
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180402
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171201
STAT- MEDLINE
DOCNO- medline/29197814

274 - TOXLINE
TI - Using Qmsax* to evaluate the reasonable As(V) adsorption on soils with
different pH.
AU - Lu G
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling 712100, Shaanxi, China.
AU - Tian H
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling 712100, Shaanxi, China.
AU - Liu Y
AD - Global Centre for Environmental Research, The Faculty of Science and
Information Technology, University of Newcastle, University Drive, Callaghan, NSW
2308, Australia; Cooperative Research Centre for Contamination Assessment and
Remediation of the Environment (CRC CARE), Callaghan, NSW 2308, Australia.
AU - Naidu R
AD - Global Centre for Environmental Research, The Faculty of Science and
Information Technology, University of Newcastle, University Drive, Callaghan, NSW
2308, Australia; Cooperative Research Centre for Contamination Assessment and
Remediation of the Environment (CRC CARE), Callaghan, NSW 2308, Australia.
AU - Wang Z
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling 712100, Shaanxi, China.
AU - He W
AD - College of Natural Resources and Environment, Northwest A&amp;F University,
Key Laboratory of Plant Nutrition and Agro-environment in Northwest China, Ministry
of Agriculture, Yangling 712100, Shaanxi, China. Electronic address:
wenxiang.he@nwafu.edu.cn.
SO - Ecotoxicol Environ Saf. 2018, Sep 30; 160:308-315. [Ecotoxicology and
environmental safety]
AB - As a toxic metalloid element, arsenic (As) derived from human activities
can pose hazardous risks to soil and water. The bioavailability of arsenic
is influenced by its behavior, in particular its adsorption-desorption in
the soil environment. The maximum adsorption amount (Qmax) calculated from
Langmuir equation is an important parameter to estimate the adsorption
capacity of adsorbents. However, the soil is a more complicated system
compared with specific adsorbents. Thus, in this study, we tried to find a
more reasonable parameter (Qmax*) to evaluate the adsorption capacity of
soils. Eighteen Chinese soil samples with different pH were used for
adsorption-desorption experiments. The maximum As(V) adsorption capacity
calculated through Langmuir fitting for 18 samples were ranged from 50.25
(S13) to 312.50 (S4) mg&#8239;kg-1. Besides, Qmax was highly related with
soil pH. Using the difference value of adsorption amount and desorption
amount to indicate the amount of non-electrostatic adsorption of As(V)
onto soils, calculated the maximum adsorption amount of non-electrostatic
adsorption (Qmax*). The average Qmax* of acidic and neutral soils was
162.18&#8239;mg&#8239;kg-1 whereas that for alkaline soils it was only
79.52&#8239;mg&#8239;kg-1. The result from multiple linear regression
analysis showed Qmax* was strongly influenced by Feox and clay contents.
Furthermore, hysteresis index (HI) in the As(V) desorption varied from
0.83 (S13) to 1.82 (S6). The results further indicated the risk of
secondary pollution originating from the desorption process cannot be
ignored.
KW - Arsenic
KW - Desorption
KW - Non-electrostatic adsorption
KW - Principle component analysis
KW - Soil
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180607
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180529
STAT- In-Process
DOCNO- medline/29857235

275 - TOXLINE
TI - Heavy metal contamination of prenatal vitamins.
AU - Schwalfenberg G
AD - University of Alberta, Canada.
AU - Rodushkin I
AD - Lule� University of Technology, Sweden.
AU - Genuis SJ
AD - Department of Obstetrics and Gynecology, University of Alberta, Canada.
SO - Toxicol Rep. 2018; 5:390-395. [Toxicology reports]
AB - Prenatal vitamins are often consumed daily during gestation and
postnatally for up to 18-24 months with the belief that supplementation
achieves better outcomes. Detrimental effects of gestational exposure to
adverse chemical agents are gathering increasing attention. This study was
designed to assess toxic element contamination in prenatal supplements.
Twenty-six commonly used prenatal vitamin brands including one
prescription brand were collected from Canadian health-food outlets and
pharmacies, and tested for toxic element contamination. Results were
compared to established endpoints. All samples contained Lead with average
amounts being (0.535&#8239;&mu;gm), 20/51 samples exceeded established
standards for lead toxicity (0.50&#8239;&mu;gm/day), with one sample
yielding 4. &mu;gm/day. Three samples registered inorganic arsenic levels
above acceptable limits. Cadmium levels did not exceed current standards.
Toxic elements such as Aluminum, Nickel, Titanium and Thallium were
detected in all samples. Cumulative intake of prenatal supplement over
many months may constitute a significant source of toxic element exposure
to the mother and offspring. With several samples exceeding known
standards for gestational toxic element exposure, guidelines for routine
monitoring and reporting are required. In keeping with recommendations
from the International Federation of Obstetrics and Gynecology, industry
regulation would be welcomed to protect expectant mothers and their
vulnerable offspring.
KW - Aluminum
KW - Arsenic
KW - Cadmium
KW - Fetus
KW - Lead
KW - Mercury
KW - Pregnancy
KW - Thallium
KW - Titanium
KW - Toxic metals
LA - eng
IS - 2214-7500 (Electronic)
PT - Journal Article
TA - Toxicol Rep
YR - 2018
DATE- 20180603
CITO- NLM
CS - Ireland
FJT - Toxicology reports
EDAT- 20180306
STAT- PubMed-not-MEDLINE
CM - Cites: PLoS One. 2014 Jun 25;9(6):e98771 (medline /24964083)
CM - Cites: Hum Exp Toxicol. 2017 Jun;36(6):554-564 (medline /28539089)
CM - Cites: N Engl J Med. 1997 May 29;336(22):1557-61 (medline /9164811)
CM - Cites: Part Fibre Toxicol. 2009 Jul 29;6:20 (medline /19640265)
CM - Cites: Biomed Res Int. 2013;2013:701439 (medline /23936836)
CM - Cites: Int J Mol Sci. 2014 Dec 03;15(12):22374-91 (medline /25479081)
CM - Cites: Environ Sci Pollut Res Int. 2003;10(5):335-40 (medline /14535650)
CM - Cites: Transl Psychiatry. 2014 Feb 11;4:e360 (medline /24518398)
CM - Cites: Environ Health Perspect. 2009 Sep;117(9):1466-71 (medline
/19750115)
CM - Cites: Biomed Res Int. 2016;2016:6150976 (medline /27314031)
CM - Cites: J Agric Food Chem. 2008 Aug 27;56(16):6892-6 (medline /18646762)
CM - Cites: J Matern Fetal Neonatal Med. 2010 Aug;23(8):932-4 (medline
/20459344)
CM - Cites: Environ Health Perspect. 2010 May;118(5):712-9 (medline /20056561)
CM - Cites: Reprod Toxicol. 2015 Jan;51:1-6 (medline /25462788)
CM - Cites: Ann N Y Acad Sci. 2010 Mar;1190:104-17 (medline /20388141)
CM - Cites: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2017
Jul;60(7):715-721 (medline /28516261)
CM - Cites: Environ Sci Technol. 2016 Nov 15;50(22):12464-12472 (medline
/27700069)
CM - Cites: Environ Toxicol Pharmacol. 2014 Mar;37(2):617-25 (medline
/24577229)
CM - Cites: Environ Res. 2017 Aug;157:173-181 (medline /28570961)
CM - Cites: Food Chem Toxicol. 2016 Oct;96:174-6 (medline /27515866)
CM - Cites: PLoS One. 2015 Mar 30;10(3):e0123265 (medline /25822975)
CM - Cites: Environ Health Perspect. 2012 Mar;120(3):445-50 (medline /21947582)
CM - Cites: Pediatrics. 2014 Dec;134(6):1151-9 (medline /25422017)
CM - Cites: J Toxicol Sci. 2010 Oct;35(5):749-56 (medline /20930469)
CM - Cites: Occup Environ Med. 2011 Sep;68(9):641-6 (medline /21186202)
CM - Cites: Environ Sci Technol. 2004 Aug 1;38(15):4140-8 (medline /15352453)
CM - Cites: Bol Estud Med Biol. 1989 Jul-Dec;37(3-4):95-9 (medline /2633791)
CM - Cites: Environ Health Perspect. 2016 Jan;124(1):164-9 (medline /26009470)
CM - Cites: Environ Health Perspect. 2009 May;117(5):A190-1 (medline /19478978)
CM - Cites: J Epidemiol Community Health. 1997 Apr;51(2):151-9 (medline
/9196644)
CM - Cites: Environ Pollut. 2013 Apr;175:30-4 (medline /23321271)
CM - Cites: Am J Clin Nutr. 2007 Jan;85(1):269S-276S (medline /17209208)
CM - Cites: PLoS One. 2012;7(6):e38713 (medline /22719926)
CM - Cites: J Epidemiol Community Health. 2005 Feb;59(2):101-5 (medline
/15650139)
CM - Cites: JAMA. 2008 Aug 27;300(8):915-23 (medline /18728265)
CM - Cites: Eur J Epidemiol. 2016 Nov;31(11):1123-1134 (medline /27147065)
CM - Cites: J Korean Med Sci. 2013 Apr;28(4):516-21 (medline /23580123)
CM - Cites: Environ Res. 2016 Nov;151:628-634 (medline /27611993)
CM - Cites: Teratog Carcinog Mutagen. 1988;8(1):13-23 (medline /2897721)
CM - Cites: J Toxicol. 2013;2013:370460 (medline /24260033)
CM - Cites: Int J Gynaecol Obstet. 2015 Dec;131(3):219-25 (medline /26433469)
CM - Cites: Biol Trace Elem Res. 2009 Dec;132(1-3):51-9 (medline /19404590)
CM - Cites: Nat Nanotechnol. 2011 May;6(5):321-8 (medline /21460826)
CM - Cites: PLoS One. 2012;7(11):e49676 (medline /23185404)
CM - Cites: Lancet. 1998 Feb 28;351(9103):643-4 (medline /9500322)
CM - Cites: Environ Health Perspect. 2009 Jul;117(7):1021-2 (medline /19654907)
CM - Cites: Chemosphere. 2014 Feb;96:99-104 (medline /23972732)
CM - Cites: J Expo Sci Environ Epidemiol. 2017 Sep;27(5):491-496 (medline
/27436694)
CM - Cites: JAMA. 2007 Jun 27;297(24):2755-9 (medline /17595277)
CM - Cites: Science. 1979 Mar 23;203(4386):1194-5 (medline /424746)
CM - Cites: Environ Pollut. 2016 Apr;211:67-73 (medline /26736057)
CM - Cites: Environ Health Perspect. 2007 Dec;115(12):A575; author reply A576-7
(medline /18087569)
CM - Cites: J Occup Environ Med. 2010 Nov;52(11):1106-11 (medline /21063188)
CM - Cites: Rev Environ Health. 2014;29(1-2):9-12 (medline /24552957)
CM - Cites: Environ Sci Pollut Res Int. 2003;10(3):192-8 (medline /12846382)
CM - Cites: Toxicol Lett. 2002 Jan 25;126(2):107-19 (medline /11751015)
CM - Cites: Environ Health Perspect. 2006 Nov;114(11):1730-5 (medline
/17107860)
CM - Cites: ScientificWorldJournal. 2015;2015:318595 (medline /26347061)
CM - Cites: Environ Res. 2017 Aug;157:160-172 (medline /28570960)
CM - Cites: Environ Health Perspect. 2016 Aug;124(8):1308-15 (medline
/26859631)
CM - Cites: Environ Health Perspect. 2008 May;116(5):674-9 (medline /18470301)
CM - Cites: JAMA. 1999 Mar 24-31;281(12):1106-9 (medline /10188661)
CM - Cites: World J Pediatr. 2014 May;10(2):101-7 (medline /24801228)
DOCNO- medline/29854609

276 - TOXLINE
TI - Arsenic, cadmium and lead in fresh and processed tuna marketed in Galicia
(NW Spain): Risk assessment of dietary exposure.
AU - N��ez R
AD - Department of Toxicology, Faculty of Veterinary. University of Santiago de
Compostela, 27002 Lugo, Spain.
AU - Garc�a M�
AD - Department of Toxicology, Faculty of Veterinary. University of Santiago de
Compostela, 27002 Lugo, Spain.
AU - Alonso J
AD - Department of Toxicology, Faculty of Veterinary. University of Santiago de
Compostela, 27002 Lugo, Spain.
AU - Melgar MJ
AD - Department of Toxicology, Faculty of Veterinary. University of Santiago de
Compostela, 27002 Lugo, Spain. Electronic address: mj.melgar@usc.es.
SO - Sci Total Environ. 2018, Jun 15; 627:322-331. [The Science of the total
environment]
AB - Currently, metal bioaccumulation in fish is increasing and is a cause of
concern due to toxicity. Total arsenic, cadmium and lead concentrations in
fresh and processed tuna (110 samples) marketed in Galicia (NW Spain) were
determined by ICP-MS spectrometry. The average concentrations of As and
Cd, 3.78 and 0.024&#8239;mg&#8239;kg-1 w.w., respectively, in fresh tuna
were statistically significantly higher than those in processed tuna
(p&#8239; < &#8239;0.001). The contents in processed tuna were
0.295-7.85&#8239;mg&#8239;kg-1 for As and ND-0.045&#8239;mg&#8239;kg-1 for
Cd. The Pb content was negligible in both types of tuna. In canned tuna,
decreasing As and Cd concentrations were observed in different
preparation-packaging media: olive
oil&#8239; > &#8239;natural&#8239; > &#8239;pickled sauce. Of the two
species studied in canned tuna, Thunnus alalunga showed statistically
significant higher levels both for As 1.28&#8239;mg&#8239;kg-1
(p&#8239; < &#8239;0.001) and Pb 0.013&#8239;mg&#8239;kg-1
(p&#8239;=&#8239;0.0496) than Thunnus albacares. No samples surpassed the
limits set by the EU for Cd and Pb. The limit for As in fish has not been
established, but the arsenic contents in fresh tuna reported here are
important, as they are among the highest reported in the literature.
Considering public health in children and adults with respect to the
investigated metals, the estimated daily intakes (EDIs) did not exceed the
tolerable intakes. No chronic systemic risk was found since all the target
hazard quotients (THQs-TTHQs) were far below 1 (critical value), and the
carcinogenic risk (CR) for As did not exceed the acceptable value of 10-5.
Thus, tuna consumption in the Galician diet does not pose a risk for
different population groups in terms of these studied metals/metalloids.
KW - Arsenic
KW - Cadmium
KW - Lead
KW - Risk assessment
KW - Tuna
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180327
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180203
STAT- In-Process
DOCNO- medline/29426155

277 - TOXLINE
TI - Engineering rice with lower grain arsenic.
AU - Deng F
AD - Department of Integrative Bioscience and Biotechnology, Pohang University of
Science and Technology, Pohang, Korea.
AU - Yamaji N
AD - Institute of Plant Science and Resources, Okayama University, Kurashiki,
Japan.
AU - Ma JF
AD - Institute of Plant Science and Resources, Okayama University, Kurashiki,
Japan.
AU - Lee SK
AD - Graduate School of Biotechnology &amp; Crop Biotech Institute, Kyung Hee
University, Yongin, Korea.
AU - Jeon JS
AD - Graduate School of Biotechnology &amp; Crop Biotech Institute, Kyung Hee
University, Yongin, Korea.
AU - Martinoia E
AD - Institute of Plant Biology, University Zurich, Zurich, Switzerland.
AU - Lee Y
AD - Department of Integrative Bioscience and Biotechnology, Pohang University of
Science and Technology, Pohang, Korea.
AU - Song WY
AD - Department of Integrative Bioscience and Biotechnology, Pohang University of
Science and Technology, Pohang, Korea.
SO - Plant Biotechnol J. 2018, Feb 26. [Plant biotechnology journal]
AB - Arsenic (As) is a poisonous element that causes severe skin lesions and
cancer in humans. Rice (Oryza sativa L.) is a major dietary source of As
in humans who consume this cereal as a staple food. We hypothesized that
increasing As vacuolar sequestration would inhibit its translocation into
the grain and reduce the amount of As entering the food chain. We
developed transgenic rice plants expressing two different vacuolar As
sequestration genes, ScYCF1 and OsABCC1, under the control of the RCc3
promoter in the root cortical and internode phloem cells, along with a
bacterial &gamma;-glutamylcysteine synthetase driven by the maize UBI
promoter. The transgenic rice plants exhibited reduced root-to-shoot and
internode-to-grain As translocation, resulting in a 70% reduction in As
accumulation in the brown rice without jeopardizing agronomic traits. This
technology could be used to reduce As intake, particularly in populations
of South East Asia suffering from As toxicity and thereby improve human
health.
KW - ABC transporter
KW - arsenic
KW - rice
KW - vacuolar sequestration
LA - eng
IS - 1467-7652 (Electronic)
PT - Journal Article
TA - Plant Biotechnol J
YR - 2018
DATE- 20180326
CI - &copy; 2018 The Authors. Plant Biotechnology Journal published by Society
for Experimental Biology and The Association of Applied Biologists and
John Wiley &amp; Sons Ltd.
CITO- NLM
CS - England
FJT - Plant biotechnology journal
EDAT- 20180226
STAT- Publisher
DOCNO- medline/29479780

278 - TOXLINE
TI - Application of glycine reduces arsenic accumulation and toxicity in Oryza
sativa L. by reducing the expression of silicon transporter genes.
AU - Kumar Dubey A
AD - CSIR-National Botanical Research Institute, Lucknow, India; Department of
Biotechnology, Kumaun University, Bhimtal Campus, Nainital 263136, India.
AU - Kumar N
AD - CSIR-National Botanical Research Institute, Lucknow, India.
AU - Ranjan R
AD - CSIR-National Botanical Research Institute, Lucknow, India.
AU - Gautam A
AD - CSIR-National Botanical Research Institute, Lucknow, India.
AU - Pande V
AD - Department of Biotechnology, Kumaun University, Bhimtal Campus, Nainital
263136, India.
AU - Sanyal I
AD - CSIR-National Botanical Research Institute, Lucknow, India.
AU - Mallick S
AD - CSIR-National Botanical Research Institute, Lucknow, India. Electronic
address: shekharm@nbri.res.in.
SO - Ecotoxicol Environ Saf. 2018, Feb; 148:410-417. [Ecotoxicology and
environmental safety]
AB - The present study was intended to investigate the role of amino acid
glycine in detoxification of As in Oryza sativa L. The growth parameters
such as, shoot length and fresh weight were decreased during As(III) and
As(V) toxicity. However, the application of glycine recovered the growth
parameters against As stress. The application of glycine reduced the As
accumulation in all the treatments, and it was more effective against
As(III) treatment and reduced the accumulation by 68% in root and 71% in
shoot. Similarly, the translocation of As from root to shoot, was higher
against As(III) and As(V) treatments, whereas, reduced upon glycine
application. The translocation of Fe and Na was also affected by As, which
was lower under As(III) and As(V) treatments. However, the application of
glycine significantly enhanced the translocation of Fe and Na in the
shoot. Besides, the expression of lower silicon transporters i.e. Lsi-1
and Lsi-2 was observed to be significantly suppressed in the root with the
application of glycine against As treatment. Similarly, the expression of
three GRX and two GST gene isoforms were found to be significantly
increased with glycine application. Simultaneously, the activities of
antioxidant enzymes i.e. l-arginine dependent NOS, SOD, NTR and GRX were
found to be significantly enhanced in the presence of glycine. Increased
activities of antioxidant enzymes coincided with the decreased level of
TBARS and H2O2 in rice seedlings. Overall, the results suggested that the
application of glycine reduces As accumulation through suppressing the
gene expression of lower silicon transporters and ameliorates As toxicity
by enhancing antioxidants defense mechanism in rice seedlings.
KW - Accumulation
KW - Arsenic
KW - Glutaredoxin
KW - Glycine
KW - Oryza sativa
KW - Silicon transporters
RN - N712M78A8G
RN - TE7660XO1C
RN - Z4152N8IUI
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180518
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171106
STAT- MEDLINE
DOCNO- medline/29101885

279 - TOXLINE
TI - Cerium dioxide (CeO2) nanoparticles decrease arsenite (As(III))
cytotoxicity to 16HBE14o- human bronchial epithelial cells.
AU - Zeng C
AD - Department of Chemical and Environmental Engineering, The University of
Arizona, P.O. Box 210011, Tucson, AZ 85721, USA.
AU - Nguyen C
AD - Department of Chemical and Environmental Engineering, The University of
Arizona, P.O. Box 210011, Tucson, AZ 85721, USA.
AU - Boitano S
AD - Department of Physiology and The Asthma and Airway Disease Research Center,
The University of Arizona, P.O. Box 245030, Tucson, AZ 85724, USA.
AU - Field JA
AD - Department of Chemical and Environmental Engineering, The University of
Arizona, P.O. Box 210011, Tucson, AZ 85721, USA.
AU - Shadman F
AD - Department of Chemical and Environmental Engineering, The University of
Arizona, P.O. Box 210011, Tucson, AZ 85721, USA.
AU - Sierra-Alvarez R
AD - Department of Chemical and Environmental Engineering, The University of
Arizona, P.O. Box 210011, Tucson, AZ 85721, USA. Electronic address:
rsierra@email.arizona.edu.
SO - Environ Res. 2018, Jul; 164:452-458. [Environmental research]
AB - The production and application of engineered nanoparticles (NPs) are
increasing in demand with the rapid development of nanotechnology.
However, there are concerns that some of these novel materials could lead
to emerging environmental and health problems. Some NPs are able to
facilitate the transport of contaminants into cells/organisms via a
"Trojan Horse" effect which enhances the toxicity of the adsorbed
materials. In this work, we evaluated the toxicity of arsenite (As(III))
adsorbed onto cerium dioxide (CeO2) NPs to human bronchial epithelial
cells (16HBE14o-) using the xCELLigence real time cell analyzing system
(RTCA). Application of 0.5&#8239;mg/L As(III) resulted in 81.3% reduction
of cell index (CI, an RTCA measure of cell toxicity) over 48&#8239;h when
compared to control cells exposed to medium lacking As(III). However, when
the cells were exposed to 0.5&#8239;mg/L As(III) in the presence of CeO2
NPs (250&#8239;mg/L), the CI was only reduced by 12.9% compared to the
control. The CeO2 NPs had a high capacity for As(III) adsorption
(20.2&#8239;mg/g CeO2) in the bioassay medium, effectively reducing
dissolved As(III) in the aqueous solution and resulting in reduced
toxicity. Transmission electron microscopy was used to study the transport
of CeO2 NPs into 16HBE14o- cells. NP uptake via engulfment was observed
and the internalized NPs accumulated in vesicles. The results demonstrate
that dissolved As(III) in the aqueous solution was the decisive factor
controlling As(III) toxicity of 16HBE14o- cells, and that CeO2 NPs
effectively reduced available As(III) through adsorption. These data
emphasize the evaluation of mixtures when assaying toxicity.
KW - Adsorption
KW - Arsenic
KW - Cerium dioxide
KW - Cytotoxicity
KW - Nanomaterials
LA - eng
IS - 1096-0953 (Electronic)
PT - Journal Article
TA - Environ Res
YR - 2018
DATE- 20180421
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Environmental research
EDAT- 20180322
STAT- In-Data-Review
DOCNO- medline/29574255

280 - TOXLINE
TI - Green synthesis and evaluation of an iron-based metal-organic framework
MIL-88B for efficient decontamination of arsenate from water.
AU - Hou S
AD - College of Environmental Science and Engineering, State Key Laboratory of
Pollution Control and Resource Reuse, Shanghai Key Lab of Chemical Assessment and
Sustainability, Department of Chemistry, Tongji University, Siping Rd 1239, 200092
Shanghai, China. 51n@tongji.edu.cn.
AU - Wu YN
AD - College of Environmental Science and Engineering, State Key Laboratory of
Pollution Control and Resource Reuse, Shanghai Key Lab of Chemical Assessment and
Sustainability, Department of Chemistry, Tongji University, Siping Rd 1239, 200092
Shanghai, China. 51n@tongji.edu.cn.
AU - Feng L
AD - College of Environmental Science and Engineering, State Key Laboratory of
Pollution Control and Resource Reuse, Shanghai Key Lab of Chemical Assessment and
Sustainability, Department of Chemistry, Tongji University, Siping Rd 1239, 200092
Shanghai, China. 51n@tongji.edu.cn.
AU - Chen W
AD - College of Environmental Science and Engineering, State Key Laboratory of
Pollution Control and Resource Reuse, Shanghai Key Lab of Chemical Assessment and
Sustainability, Department of Chemistry, Tongji University, Siping Rd 1239, 200092
Shanghai, China. 51n@tongji.edu.cn.
AU - Wang Y
AD - College of Environmental Science and Engineering, State Key Laboratory of
Pollution Control and Resource Reuse, Shanghai Key Lab of Chemical Assessment and
Sustainability, Department of Chemistry, Tongji University, Siping Rd 1239, 200092
Shanghai, China. 51n@tongji.edu.cn.
AU - Morlay C
AD - College of Environmental Science and Engineering, State Key Laboratory of
Pollution Control and Resource Reuse, Shanghai Key Lab of Chemical Assessment and
Sustainability, Department of Chemistry, Tongji University, Siping Rd 1239, 200092
Shanghai, China. 51n@tongji.edu.cn.
AU - Li F
AD - College of Environmental Science and Engineering, State Key Laboratory of
Pollution Control and Resource Reuse, Shanghai Key Lab of Chemical Assessment and
Sustainability, Department of Chemistry, Tongji University, Siping Rd 1239, 200092
Shanghai, China. 51n@tongji.edu.cn.
SO - Dalton Trans. 2018, Feb 13; 47(7):2222-2231. [Dalton transactions
(Cambridge, England : 2003)]
AB - Iron-containing metal-organic frameworks (MOFs) have gradually emerged as
environmentally benign alternatives for reducing the levels of
environmental contamination because of their advantages, such as readily
obtained raw materials with low cost, nontoxic metal source with good
biocompatibility, and distinguished physicochemical features e.g., high
porosity, framework flexibility, and semiconductor properties. In this
study, we reported an innovative strategy for synthesizing an iron-based
MOF, MIL-88B, at room temperature. The novelty of this strategy was the
use of ethanol as solvent and the pretreatment of dry milling with neither
the bulk use of a toxic organic solvent nor the addition of extremely
dangerous hydrofluoric acid or strong alkali. The synthesized MIL-88B(Fe)
was evaluated as a sorbent for removing arsenate in water and it exhibited
high adsorption capacity (156.7 mg g-1) at a low dosage. The removal
capacity of trace arsenate on MIL-88B(Fe) was 32.3 mg g-1 at a low
equilibrium concentration (6.4 &mu;g L-1), which satisfied the arsenic
threshold for drinking water. The results of Fourier transform infrared
and X-ray photoelectron spectroscopy indicated that the As(v) molecules
bonded with the oxygen molecules, which were coordinated with FeO clusters
in the framework. This work presented the potential use of the up-scaled
MIL-88B as an excellent sorbent for purifying arsenate-contaminated water.
LA - eng
IS - 1477-9234 (Electronic)
PT - Journal Article
TA - Dalton Trans
YR - 2018
DATE- 20180323
CITO- NLM
CS - England
FJT - Dalton transactions (Cambridge, England : 2003)
STAT- PubMed-not-MEDLINE
DOCNO- medline/29363689

281 - TOXLINE
TI - Simultaneous alleviation of cadmium and arsenic accumulation in rice by
applying zero-valent iron and biochar to contaminated paddy soils.
AU - Qiao JT
AD - Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou
510640, PR China; Guangdong Key Laboratory of Integrated Agro-environmental
Pollution Control and Management, Guangdong Institute of Eco-environmental Science
&amp; Technology, Guangzhou 510650, PR China; University of Chinese Academy of
Sciences, Beijing 100049, PR China.
AU - Liu TX
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China.
AU - Wang XQ
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China.
AU - Li FB
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China. Electronic address: cefbli@soil.gd.cn.
AU - Lv YH
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China.
AU - Cui JH
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China.
AU - Zeng XD
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China.
AU - Yuan YZ
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China.
AU - Liu CP
AD - Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control
and Management, Guangdong Institute of Eco-environmental Science &amp; Technology,
Guangzhou 510650, PR China.
SO - Chemosphere. 2018, Mar; 195:260-271. [Chemosphere]
AB - The fates of cadmium (Cd) and arsenic (As) in paddy fields are generally
opposite; thus, the inconsistent transformation of Cd and As poses large
challenges for their remediation. In this study, the impacts of zero
valent iron (ZVI) and/or biochar amendments on Cd and As bioavailability
were examined in pot trials with rice. Comparison with the untreated soil,
both Cd and As accumulation in different rice tissues decreased
significantly in the ZVI-biochar amendments and the Cd and As accumulation
in rice decreased with increasing ZVI contents. In particular, the
concentrations of Cd (0.15 &plusmn; 0.01 mg kg-1) and
As (0.17 &plusmn; 0.01 mg kg-1) in rice grains were
decreased by 93% and 61% relative to the untreated soil, respectively. A
sequential extraction analysis indicated that with increasing Fe ratios in
the ZVI-biochar mixtures, bioavailable Cd and As decreased, and the
immobilized Cd and As increased. Furthermore, high levels of Fe, Cd, and
As were detected in Fe plaque of the ZVI-biochar amendments in comparison
with the single biochar or single ZVI amendments. The ZVI-biochar mixture
may have a synergistic effect that simultaneously reduces Cd and As
bioavailability by increasing the formation of amorphous Fe and Fe plaque
for Cd and As immobilization. The single ZVI amendment significantly
decreased As bioavailability, while the single biochar amendment
significantly reduced the bioavailability of Cd compared with the combined
amendments. Hence, using a ZVI-biochar mixture as a soil amendment could
be a promising strategy for safely-utilizing Cd and As co-contaminated
sites in the future.
KW - Bioavailable As and Cd
KW - Biochar
KW - Fe fractions
KW - Paddy soil
KW - Zero-valent iron
RN - 00BH33GNGH
RN - 16291-96-6
RN - E1UOL152H7
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180518
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171213
STAT- MEDLINE
DOCNO- medline/29272795

282 - TOXLINE
TI - Three-dimensional spatial variability of arsenic-containing soil from
geogenic source in Hong Kong: Implications on sampling strategies.
AU - Leung YF
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong, China. Electronic address:
andy.yf.leung@polyu.edu.hk.
AU - Liu W
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong, China.
AU - Li JS
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong, China.
AU - Wang L
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong, China.
AU - Tsang DCW
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong, China. Electronic address:
dan.tsang@polyu.edu.hk.
AU - Lo CY
AD - Civil Engineering and Development Department, Hong Kong, China.
AU - Leung MT
AD - Civil Engineering and Development Department, Hong Kong, China.
AU - Poon CS
AD - Department of Civil and Environmental Engineering, The Hong Kong Polytechnic
University, Hung Hom, Kowloon, Hong Kong, China.
SO - Sci Total Environ. 2018, Aug 15; 633:836-847. [The Science of the total
environment]
AB - Soil contamination by trace elements such as arsenic (As) can pose
considerable threats to human health, and need to be carefully identified
through site investigation before the soil remediation and development
works. However, due to the high costs of soil sampling and testing,
decisions on risk management or mitigation strategies are often based on
limited data at the site, with substantial uncertainty in the spatial
distributions of potentially toxic elements. This study incorporates the
restricted maximum likelihood method with three-dimensional spatial
autocovariance structure, to investigate the spatial variability features
of As-containing soils of geogenic origin. A recent case study in Hong
Kong is presented, where > 550 samples were retrieved and tested for
distributions of As concentrations. The proposed approach is applied to
characterize their spatial correlation patterns, to predict the As
concentrations at unsampled locations, and to quantify the uncertainty of
such estimates. The validity of the approach is illustrated by utilizing
the multi-stage site investigation data, through which the advantages of
the approach over traditional geostatistical methods are revealed and
discussed. The new approach also quantifies the effectiveness of soil
sampling on reduction of uncertainty levels across the site. This can
become a useful indicator for risk management or mitigation strategies, as
it is often necessary to balance between the available resources for soil
sampling at the site and the needs for proper characterization of
contaminant distributions.
KW - Geogenic arsenic
KW - Restricted maximum likelihood
KW - Site investigation
KW - Soil remediation
KW - Spatial variability
KW - Trace elements
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180518
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180328
STAT- PubMed-not-MEDLINE
DOCNO- medline/29602121

283 - TOXLINE
TI - Taxonomy and physiology of Pseudoxanthomonas arseniciresistens sp. nov.,
an arsenate and nitrate-reducing novel gammaproteobacterium from arsenic
contaminated groundwater, India.
AU - Mohapatra B
AD - Department of Biotechnology, Indian Institute of Technology Kharagpur,
Kharagpur, West Bengal, India.
AU - Sar P
AD - Department of Biotechnology, Indian Institute of Technology Kharagpur,
Kharagpur, West Bengal, India.
AU - Kazy SK
AD - Department of Biotechnology, National Institute of Technology Durgapur,
Durgapur, West Bengal, India.
AU - Maiti MK
AD - Department of Biotechnology, Indian Institute of Technology Kharagpur,
Kharagpur, West Bengal, India.
AU - Satyanarayana T
AD - Department of Microbiology, University of Delhi South Campus (UDSC), New
Delhi, Delhi, India.
SO - PLoS One. 2018; 13(3):e0193718. [PloS one]
AB - Reductive transformation of toxic arsenic (As) species by As reducing
bacteria (AsRB) is a key process in As-biogeochemical-cycling within the
subsurface aquifer environment. In this study, we have characterized a
Gram-stain-negative, non-spore-forming, rod-shaped As reducing bacterium
designated KAs 5-3T, isolated from highly As-contaminated groundwater of
India. Strain KAs 5-3T displayed high 16S rRNA gene sequence similarity to
the members of the genus Pseudoxanthomonas, with P. mexicana AMX 26BT
(99.25% similarity), P. japonensis 12-3T (98.9&#8202;0%), P. putridarboris
WD-12T (98.02%), and P. indica P15T (97.27%) as closest phylogenetic
neighbours. DNA-DNA hybridization study unambiguously indicated that
strain KAs 5-3T represented a novel species that was separate from
reference strains of P. mexicana AMX 26BT (35.7%), P. japonensis 12-3T
(35.5%), P. suwonensis 4M1T (35.5%), P. wuyuanensis XC21-2T (35.0%), P.
indica P15T (32.5%), P. daejeonensis TR6-08T (32.0%), and P. putridarboris
WD12T (22.1%). The DNA G+C content of strain KAs 5-3T was 64.9 mol %. The
predominant fatty acids were C15:0 (37.4%), C16:0 iso (12.6%), C17:1 iso
&omega;9c (10.5%), C15:0 anteiso (9.5%), C11:0 iso 3-OH (8.5%), and C16:1
&omega;7c/ C16:1 &omega;6c (7.5%). The major polar lipids were
diphosphatidylglycerol, phosphatidyldimethylethanolamine,
phosphatidylcholine, and two unknown phospholipids (PL1, PL2). Ubiquinone
8 (Q8) was the predominant respiratory quinone and spermidine was the
major polyamine of the strain KAs 5-3T. Cells of strain KAs 5-3T showed
the ability to use O2, As5+, NO3-, NO2-, and Fe3+ as terminal electron
acceptors as well as to reduce As5+ through the cytosolic process under
aerobic incubations. Genes encoding arsenate reductase (arsC) for
As-detoxification, nitrate- and nitrite reductase (narG and nirS) for
denitrification were detected in the strain KAs 5-3T. Based on taxonomic
and physiological data, strain KAs 5-3T is described as a new
representative member of the genus Pseudoxanthomonas, for which the name
Pseudoxanthomonas arseniciresistens sp. nov. is proposed. The type strain
is KAs 5-3T (= LMG 29169T = MTCC 12116T = MCC 3121T).
LA - eng
IS - 1932-6203 (Electronic)
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
TA - PLoS One
YR - 2018
DATE- 20180618
CITO- NLM
CS - United States
FJT - PloS one
EDAT- 20180320
STAT- In-Process
CM - Cites: J Clin Microbiol. 1982 Nov;16(5):948-52 (medline /6185531)
CM - Cites: Int J Syst Evol Microbiol. 2006 Jun;56(Pt 6):1363-7 (medline
/16738115)
CM - Cites: Int J Syst Evol Microbiol. 2002 May;52(Pt 3):1043-7 (medline
/12054223)
CM - Cites: Int J Syst Evol Microbiol. 2005 Mar;55(Pt 2):787-91 (medline
/15774663)
CM - Cites: Int J Syst Evol Microbiol. 2006 Mar;56(Pt 3):659-62 (medline
/16514045)
CM - Cites: Mol Biol Evol. 1987 Jul;4(4):406-25 (medline /3447015)
CM - Cites: J Bacteriol. 1994 Jun;176(12 ):3749-56 (medline /8206853)
CM - Cites: PLoS One. 2012;7(12):e50225 (medline /23226514)
CM - Cites: Ecotoxicology. 2013 Mar;22(2):363-76 (medline /23238642)
CM - Cites: Int J Syst Evol Microbiol. 2008 Sep;58(Pt 9):2235-40 (medline
/18768635)
CM - Cites: Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):2155-61 (medline
/12508883)
CM - Cites: Microbiol Rev. 1990 Sep;54(3):305-15 (medline /2215423)
CM - Cites: ISME J. 2014 Sep;8(9):1932-44 (medline /24671084)
CM - Cites: PLoS One. 2015 Mar 23;10(3):e0118735 (medline /25799109)
CM - Cites: Int J Syst Evol Microbiol. 2006 May;56(Pt 5):1103-7 (medline
/16627662)
CM - Cites: Int J Syst Evol Microbiol. 2007 Aug;57(Pt 8):1823-7 (medline
/17684265)
CM - Cites: Appl Environ Microbiol. 1986 Oct;52(4):751-7 (medline /16347168)
CM - Cites: Antonie Van Leeuwenhoek. 2014 Apr;105(4):653-61 (medline /24477814)
CM - Cites: Am J Clin Pathol. 1953 May;23(5):512 (medline /13040307)
CM - Cites: Arch Microbiol. 2017 Mar;199(2):191-201 (medline /27663709)
CM - Cites: J Hazard Mater. 2012 Jan 30;201-202:43-51 (medline /22169141)
CM - Cites: Appl Environ Microbiol. 2005 Jun;71(6):3355-8 (medline /15933041)
CM - Cites: Am J Clin Pathol. 1966 Apr;45(4):493-6 (medline /5325707)
CM - Cites: Appl Environ Microbiol. 2005 Feb;71(2):599-608 (medline /15691908)
CM - Cites: Eur J Biochem. 1970 Jan;12(1):133-42 (medline /4984993)
CM - Cites: Int J Syst Evol Microbiol. 2011 Sep;61(Pt 9):2107-11 (medline
/20870889)
CM - Cites: FEMS Microbiol Lett. 2011 Jul;320(2):128-34 (medline /21545490)
CM - Cites: Appl Environ Microbiol. 2011 Nov;77(22):7962-74 (medline /21948834)
CM - Cites: Genome Res. 2000 Nov;10(11):1719-25 (medline /11076857)
CM - Cites: Int J Syst Evol Microbiol. 2000 Jan;50 Pt 1:273-82 (medline
/10826814)
CM - Cites: Mol Biol Evol. 2016 Jul;33(7):1870-4 (medline /27004904)
CM - Cites: Int J Syst Evol Microbiol. 2015 Sep;65(9):3170-4 (medline
/26297383)
CM - Cites: J Mol Biol. 1990 Oct 5;215(3):403-10 (medline /2231712)
CM - Cites: Int J Syst Evol Microbiol. 2014 Feb;64(Pt 2):316-24 (medline
/24505069)
CM - Cites: Geobiology. 2010 Mar;8(2):155-68 (medline /20156294)
CM - Cites: Int J Syst Evol Microbiol. 2014 Mar;64(Pt 3):799-804 (medline
/24215823)
CM - Cites: FEMS Microbiol Rev. 2001 Jan;25(1):39-67 (medline /11152940)
CM - Cites: Environ Sci Pollut Res Int. 2014;21(14):8645-62 (medline /24764001)
CM - Cites: Syst Appl Microbiol. 2005 Mar;28(2):137-44 (medline /15830806)
CM - Cites: Int J Syst Evol Microbiol. 2017 May;67(5):1613-1617 (medline
/28005526)
CM - Cites: Int J Syst Evol Microbiol. 2012 Mar;62(Pt 3):716-21 (medline
/22140171)
CM - Cites: Nucleic Acids Res. 2001 Jan 1;29(1):173-4 (medline /11125082)
CM - Cites: Nucleic Acids Res. 2003 Jul 1;31(13):3784-8 (medline /12824418)
CM - Cites: Extremophiles. 2005 Feb;9(1):75-9 (medline /15351875)
CM - Cites: Int J Syst Evol Microbiol. 2016 Dec;66(12 ):5034-5038 (medline
/27582419)
CM - Cites: Int J Syst Evol Microbiol. 2007 Mar;57(Pt 3):646-9 (medline
/17329800)
CM - Cites: Front Microbiol. 2013 Mar 12;4:41 (medline /23487592)
CM - Cites: Int J Syst Evol Microbiol. 2017 Jun;67(6):1807-1812 (medline
/28598308)
CM - Cites: Syst Appl Microbiol. 2015 Jun;38(4):237-45 (medline /25959541)
CM - Cites: Mol Biol Evol. 2000 Aug;17(8):1251-8 (medline /10908645)
CM - Cites: Mol Biol Evol. 2006 Feb;23(2):254-67 (medline /16221896)
CM - Cites: J Mol Evol. 1981;17(6):368-76 (medline /7288891)
CM - Cites: Int J Syst Evol Microbiol. 2004 Nov;54(Pt 6):2245-55 (medline
/15545466)
CM - Cites: Res Microbiol. 2007 Mar;158(2):128-37 (medline /17258434)
DOCNO- medline/29558470

284 - TOXLINE
TI - In vivo and in vitro methods for evaluating soil arsenic bioavailability:
relevant to human health risk assessment.
AU - Bradham KD
AD - a Public Health Chemistry Branch, Exposure Methods and Measurements Division,
National Exposure Research Laboratory , Office of Research and Development, U.S.
Environmental Protection Agency , Research Triangle Park , NC , USA.
AU - Diamond GL
AD - b SRC Inc ., North Syracuse , NY , USA.
AU - Burgess M
AD - c Science Policy Branch, Office of Superfund Remediation and Technology
Innovation, Office of Land and Emergency Management , US Environmental Protection
Agency , Arlington , VA , USA.
AU - Juhasz A
AD - d Future Industries Institute , University of South Australia , Adelaide , SA
, Australia.
AU - Klotzbach JM
AD - b SRC Inc ., North Syracuse , NY , USA.
AU - Maddaloni M
AD - e Region 2 , U.S. Environmental Protection Agency , New York , NY , USA.
AU - Nelson C
AD - a Public Health Chemistry Branch, Exposure Methods and Measurements Division,
National Exposure Research Laboratory , Office of Research and Development, U.S.
Environmental Protection Agency , Research Triangle Park , NC , USA.
AU - Scheckel K
AD - f Land Remediation and Pollution Control Division, National Risk Management
Research Laboratory , Office of Research and Development, U.S. Environmental
Protection Agency , Cincinnati , Ohio.
AU - Serda SM
AD - g Region 9 , U.S. Environmental Protection Agency , San Francisco , CA , USA.
AU - Stifelman M
AD - h Region 10 , U.S. Environmental Protection Agency , Seattle , WA , USA.
AU - Thomas DJ
AD - i Pharmacokinetics Branch, Integrated Systems Toxicology Division, National
Health and Environmental Effects Research Laboratory , Office of Research and
Development, U.S. Environmental Protection Agency , Research Triangle Park , NC ,
USA.
SO - J Toxicol Environ Health B Crit Rev. 2018; 21(2):83-114. [Journal of
toxicology and environmental health. Part B, Critical reviews]
AB - Arsenic (As) is the most frequently occurring contaminant on the priority
list of hazardous substances, which lists substances of greatest public
health concern to people living at or near U.S. National Priorities List
site. Accurate assessment of human health risks from exposure to
As-contaminated soils depends on estimating its bioavailability, defined
as the fraction of ingested As absorbed across the gastrointestinal
barrier and available for systemic distribution and metabolism. Arsenic
bioavailability varies among soils and is influenced by site-specific soil
physical and chemical characteristics and internal biological factors.
This review describes the state-of-the science that supports our
understanding of oral bioavailability of soil As, the methods that are
currently being explored for estimating soil As relative bioavailability
(RBA), and future research areas that could improve our prediction of the
oral RBA of soil As in humans. The following topics are addressed: (1) As
soil geochemistry; (2) As toxicology; (3) in vivo models for estimating As
RBA; (4) in vitro bioaccessibility methods; and (5) conclusions and
research needs.
LA - eng
IS - 1521-6950 (Electronic)
PT - Journal Article
TA - J Toxicol Environ Health B Crit Rev
YR - 2018
DATE- 20180319
CITO- NLM
CS - England
FJT - Journal of toxicology and environmental health. Part B, Critical reviews
STAT- In-Data-Review
DOCNO- medline/29553912

285 - TOXLINE
TI - Bioindication of mercury, arsenic and uranium in the apple snail Pomacea
canaliculata (Caenogastropoda, Ampullariidae): Bioconcentration and
depuration in tissues and symbiotic corpuscles.
AU - Campoy-Diaz AD
AD - IHEM, CONICET, Universidad Nacional de Cuyo, 5500 Mendoza, Argentina;
Universidad Nacional de Cuyo, Facultad de Ciencias M�dicas, Instituto de
Fisiolog�a, 5500 Mendoza, Argentina.
AU - Arrib�re MA
AD - Instituto Balseiro, Universidad Nacional de Cuyo, Comisi�n Nacional de
Energ�a At�mica, 8400 Bariloche, Argentina.
AU - Guevara SR
AD - Instituto Balseiro, Universidad Nacional de Cuyo, Comisi�n Nacional de
Energ�a At�mica, 8400 Bariloche, Argentina.
AU - Vega IA
AD - IHEM, CONICET, Universidad Nacional de Cuyo, 5500 Mendoza, Argentina;
Universidad Nacional de Cuyo, Facultad de Ciencias M�dicas, Instituto de
Fisiolog�a, 5500 Mendoza, Argentina; Universidad Nacional de Cuyo, Facultad de
Ciencias Exactas y Naturales, Departamento de Biolog�a, 5500 Mendoza, Argentina.
Electronic address: ivega@mendoza-conicet.gob.ar.
SO - Chemosphere. 2018, Apr; 196:196-205. [Chemosphere]
AB - Pomacea canaliculata is a mollusk potentially useful as a biomonitor
species of freshwater quality. This work explores the ability of snail
tissues and symbiotic corpuscles to bioconcentrate and depurate mercury,
arsenic, and uranium. Adult snails cultured in metal-free reconstituted
water were exposed for eight weeks (bioaccumulation phase) to water with
Hg (2&#8239;&mu;gL-1), As (10&#8239;&mu;gL-1), and U (30&#8239;&mu;gL-1)
and then returned to the reconstituted water for other additional eight
weeks (depuration phase). Elemental concentrations in digestive gland,
kidney, symbiotic corpuscles and particulate excreta were determined by
neutron activation analysis. The glandular symbiotic occupancy was
measured by morphometric analysis. After exposure, the kidney showed the
highest concentration of Hg, while the digestive gland accumulated mainly
As and U. The subcellular distribution in symbiotic corpuscles was
&sim;71%, &sim;48%, and &sim;11% for U, Hg, and As, respectively. Tissue
depuration between weeks 8 and 16 was variable amongst elements. At week
16, the tissue depuration of U was the highest (digestive
gland&#8239;=&#8239;92%; kidney&#8239;=&#8239;80%), while it was lower for
Hg (digestive gland&#8239;=&#8239;51%; kidney&#8239;=&#8239;53%). At week
16, arsenic showed a differential pattern of tissue depuration (digestive
gland&#8239;=&#8239;23%; kidney&#8239;=&#8239;88%). The symbiotic
detoxification of the three elements in excreta was fast between weeks 8
and 10 and it was slower after on. At the end of the depuration, each
element distributed differentially in digestive gland and symbiotic
corpuscles. Our findings show that symbiotic corpuscles, digestive gland
and kidney P. canaliculata are sensitive places for biomonitoring of
Hg, As and U.
KW - Biomonitor
KW - Cyanobacteria
KW - Environmental health
KW - Heavy metal
KW - Symbiosis
KW - Water pollution
RN - 059QF0KO0R
RN - 4OC371KSTK
RN - FXS1BY2PGL
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180517
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171226
STAT- MEDLINE
DOCNO- medline/29304457

286 - TOXLINE
TI - [Polymorphism of genes encoding proteins of DNA repair vs. occupational
and environmental exposure to lead, arsenic and pesticides].
AU - Bukowski K
AD - Uniwersytet &#321;�dzki / University of Lodz, &#321;�d&#378;, Poland
(Wydzia&#322; Biologii i Ochrony &#346;rodowiska, Katedra Genetyki Molekularnej /
Faculty of Biology and Environmental Protection, Department of Molecular Genetics).
AU - Wo&#378;niak K
AD - Uniwersytet &#321;�dzki / University of Lodz, &#321;�d&#378;, Poland
(Wydzia&#322; Biologii i Ochrony &#346;rodowiska, Katedra Genetyki Molekularnej /
Faculty of Biology and Environmental Protection, Department of Molecular Genetics).
katarzyna.wozniak@biol.uni.lodz.pl.
SO - Med Pr. 2018, Mar 09; 69(2):225-235. [Medycyna pracy]
AB - Genetic polymorphism is associated with the occurrence of at least 2
different alleles in the locus with a frequency higher than 1% in the
population. Among polymorphisms we can find single nucleotide polymorphism
(SNP) and polymorphism of variable number of tandem repeats. The presence
of certain polymorphisms in genes encoding DNA repair enzymes is
associated with the speed and efficiency of DNA repair and can protect or
expose humans to the effects provoked by xenobiotics. Chemicals, such as
lead, arsenic pesticides are considered to exhibit strong toxicity. There
are many different polymorphisms in genes encoding DNA repair enzymes,
which determine the speed and efficiency of DNA damage repair induced by
these xenobiotics. In the case of lead, the influence of various
polymorphisms, such as APE1 (apurinic/apyrimidinic endonuclease 1)
(rs1130409), hOGG1 (human 8-oxoguanine glycosylase) (rs1052133), XRCC1
(X-ray repair cross-complementing protein group 1) (rs25487), XRCC1
(rs1799782) and XRCC3 (X-ray repair cross-complementing protein group 3)
(rs861539) were described. For arsenic polymorphisms, such as ERCC2
(excision repair cross-complementing) (rs13181), XRCC3 (rs861539), APE1
(rs1130409) and hOGG1 (rs1052133) were examined. As to pesticides,
separate and combined effects of polymorphisms in genes encoding DNA
repair enzymes, such as XRCC1 (rs1799782), hOGG1 (rs1052133), XRCC4 (X-ray
repair cross-complementing protein group 4) (rs28360135) and the gene
encoding the detoxification enzyme PON1 paraoxonase (rs662) were reported.
Med Pr 2018;69(2):225-235.
AB - Polimorfizm genetyczny wi&#261;&#380;e si&#281; z wyst&#281;powaniem w
populacji co najmniej 2 r�&#380;nych alleli w danym locus z
cz&#281;sto&#347;ci&#261; wi&#281;ksz&#261; ni&#380; 1%.
Wyr�&#380;niamy m.in. polimorfizm pojedynczego nukleotydu (single
nucleotide polymorphism &ndash; SNP) i polimorfizm zmiennej liczby
powt�rze&#324; tandemowych. Wyst&#281;powanie okre&#347;lonych
polimorfizm�w w genach koduj&#261;cych enzymy naprawy DNA jest
zwi&#261;zane z szybko&#347;ci&#261; i wydajno&#347;ci&#261; naprawy DNA
oraz mo&#380;e chroni&#263; lub nara&#380;a&#263; dan&#261; osob&#281; na
skutki dzia&#322;ania okre&#347;lonego ksenobiotyku. Zwi&#261;zki
chemiczne takie, jak o&#322;�w, arsen i pestycydy odznaczaj&#261;
si&#281; du&#380;&#261; toksyczno&#347;ci&#261;. Opisano wiele
r�&#380;nych polimorfizm�w gen�w koduj&#261;cych
enzymy naprawy DNA, kt�re maj&#261; wp&#322;yw na
skuteczno&#347;&#263; naprawy uszkodze&#324; DNA indukowanych przez te
ksenobiotyki. W przypadku o&#322;owiu zbadano wp&#322;yw
polimorfizm�w gen�w: APE1 (apurinic/apyrimidinic
endonuclease 1 &ndash; endonukleaza miejsca apurynowego/apirymidynowego)
(rs1130409), hOGG1 (human 8-oxoguanine glycosylase &ndash; glikozylaza
8-oksyguaniny) (rs1052133), XRCC1 (X-ray repair cross-complementing
protein group 1 &ndash; bia&#322;ko bior&#261;ce udzia&#322; w naprawie
DNA przez wycinanie zasad) (rs25487), XRCC1 (rs1799782) oraz XRCC3 (X-ray
repair cross-complementing protein group 3 &ndash; bia&#322;ko
bior&#261;ce udzia&#322; w naprawie DNA przez rekombinacj&#281;
homologiczn&#261;) (rs861539). Dla arsenu przedstawiono w niniejszej pracy
wyniki bada&#324; dotycz&#261;cych nast&#281;puj&#261;cych
polimorfizm�w: ERCC2 (excision repair cross-complementing &ndash;
bia&#322;ko bior&#261;ce udzia&#322; w naprawie DNA przez wycinanie
nukleotyd�w) (rs13181), XRCC3 (rs861539), APE1 (rs1130409) oraz
hOGG1 (rs1052133). W odniesieniu do pestycyd�w w pracy
przedstawiono zar�wno osobny, jak i &#322;&#261;czny wp&#322;yw
polimorfizm�w gen�w takich, jak XRCC1 (rs1799782), hOGG1
(rs1052133), XRCC4 (X-ray repair cross-complementing protein group 4
&ndash; bia&#322;ko bior&#261;ce udzia&#322; w naprawie DNA przez
&#322;&#261;czenie ko&#324;c�w niehomologicznych) (rs28360135) i
genu koduj&#261;cego enzym detoksykacyjny paraoksonaz&#281; PON1
(paraoxonase 1) (rs662). Med. Pr. 2018;69(2):225&ndash;235.
KW - DNA damage
KW - DNA repair genes
KW - Pesticides
KW - arsenic
KW - genetic polymorphism
KW - lead
LA - pol
IS - 0465-5893 (Print)
PT - English Abstract
PT - Journal Article
PT - Review
TA - Med Pr
TT - Polimorfizm gen�w koduj&#261;cych bia&#322;ka naprawy DNA a
zawodowe i &#347;rodowiskowe nara&#380;enie na o&#322;�w, arsen i
pestycydy.
YR - 2018
DATE- 20180606
CI - This work is available in Open Access model and licensed under a CC BY-NC
3.0 PL license.
CITO- NLM
CS - Poland
FJT - Medycyna pracy
EDAT- 20171012
STAT- In-Process
DOCNO- medline/29035403

287 - TOXLINE
TI - Silicon alleviates arsenic-induced toxicity in wheat through vacuolar
sequestration and ROS scavenging.
AU - Hossain MM
AD - a Molecular Plant Physiology Laboratory , Department of Botany, University of
Rajshahi , Rajshahi , Bangladesh.
AU - Khatun MA
AD - a Molecular Plant Physiology Laboratory , Department of Botany, University of
Rajshahi , Rajshahi , Bangladesh.
AU - Haque MN
AD - a Molecular Plant Physiology Laboratory , Department of Botany, University of
Rajshahi , Rajshahi , Bangladesh.
AU - Bari MA
AD - b Institute of Biological Sciences, University of Rajshahi , Rajshahi ,
Bangladesh.
AU - Alam MF
AD - a Molecular Plant Physiology Laboratory , Department of Botany, University of
Rajshahi , Rajshahi , Bangladesh.
AU - Mandal A
AD - c Systems Biology Research Center , School of Bioscience, University of
Sk�vde , Sk�vde , Sweden.
AU - Kabir AH
AD - a Molecular Plant Physiology Laboratory , Department of Botany, University of
Rajshahi , Rajshahi , Bangladesh.
SO - Int J Phytoremediation. 2018, Jul 03; 20(8):796-804. [International
journal of phytoremediation]
AB - Arsenic (As) is a phytotoxic element causing health hazards. This work
investigates whether and how silicon (Si) alleviates As toxicity in wheat.
The addition of Si under As-stress significantly improved
morphophysiological characteristics, total protein, and membrane stability
compared to As-stressed plants, suggesting that Si does have critical
roles in As detoxification in wheat. Analysis of arsenate reductase
activity and phytosiderophore (PS) release reveals their no involvement in
the Si-mediated alleviation of As in wheat. Furthermore, Si
supplementation in As-stressed plants showed a significant increase of As
in roots but not in shoots compared with the plants grown under As stress.
Further, gene expression analysis of two chelating molecules, TaPCS1
(phytochelatin synthase) and TaMT1 (metallothionein synthase) showed
significant induction due to Si application under As stress compared with
As-stressed plants. It is consistent with the physiological observations
and suggests that alleviation of As toxicity in rice might be associated
with As sequestration in roots leading to reduced As translocation in
shoots. Furthermore, increased catalase, peroxidase, and glutathione
reductase activities in roots imply the active involvement of reactive
oxygen species scavenging for protecting wheat plants from As-induced
oxidative injury. The study provides mechanistic evidence on the
beneficial effect of Si on As toxicity in wheat plants.
KW - As stress
KW - vacuolar sequestration
KW - wheat
LA - eng
IS - 1549-7879 (Electronic)
PT - Journal Article
TA - Int J Phytoremediation
YR - 2018
DATE- 20180518
CITO- NLM
CS - United States
FJT - International journal of phytoremediation
STAT- In-Process
DOCNO- medline/29775096
288 - TOXLINE
TI - A Genomic Outlook on Bioremediation: The Case of Arsenic Removal.
AU - Plewniak F
AD - G�n�tique Mol�culaire, G�nomique et Microbiologie, UMR7156 CNRS, Universit�
de Strasbourg, Strasbourg, France.
AU - Crognale S
AD - Istituto di Ricerca sulle Acque, Consiglio Nazionale delle Ricerche, Rome,
Italy.
AU - Rossetti S
AD - Istituto di Ricerca sulle Acque, Consiglio Nazionale delle Ricerche, Rome,
Italy.
AU - Bertin PN
AD - G�n�tique Mol�culaire, G�nomique et Microbiologie, UMR7156 CNRS, Universit�
de Strasbourg, Strasbourg, France.
SO - Front Microbiol. 2018; 9:820. [Frontiers in microbiology]
AB - Microorganisms play a major role in biogeochemical cycles. As such they
are attractive candidates for developing new or improving existing
biotechnological applications, in order to deal with the accumulation and
pollution of organic and inorganic compounds. Their ability to participate
in bioremediation processes mainly depends on their capacity to metabolize
toxic elements and catalyze reactions resulting in, for example,
precipitation, biotransformation, dissolution, or sequestration. The
contribution of genomics may be of prime importance to a thorough
understanding of these metabolisms and the interactions of microorganisms
with pollutants at the level of both single species and microbial
communities. Such approaches should pave the way for the utilization of
microorganisms to design new, efficient and environmentally sound
remediation strategies, as exemplified by the case of arsenic
contamination, which has been declared as a major risk for human health in
various parts of the world.
KW - arsenic
KW - bioremediation/phytoremediation
KW - ecosystem ecology
KW - genomics
KW - microorganism
LA - eng
IS - 1664-302X (Print)
PT - Journal Article
PT - Review
TA - Front Microbiol
YR - 2018
DATE- 20180517
CITO- NLM
CS - Switzerland
FJT - Frontiers in microbiology
EDAT- 20180426
STAT- PubMed-not-MEDLINE
CM - Cites: Nat Rev Microbiol. 2003 Oct;1(1):35-44 (medline /15040178)
CM - Cites: Arch Microbiol. 1997 Nov;168(5):380-8 (medline /9325426)
CM - Cites: Environ Health Perspect. 2012 May;120(5):623-6 (medline /22336149)
CM - Cites: J Appl Microbiol. 2011 Nov;111(5):1065-74 (medline /21895895)
CM - Cites: Water Res. 2004 Jan;38(1):17-26 (medline /14630099)
CM - Cites: Bioresour Technol. 2018 May;256:152-159 (medline /29438915)
CM - Cites: Nucleic Acids Res. 2018 Jan 4;46(D1):D726-D735 (medline /29069476)
CM - Cites: Nature. 2013 Aug 29;500(7464):567-70 (medline /23892779)
CM - Cites: Appl Environ Microbiol. 2017 Mar 31;83(8): (medline /28188207)
CM - Cites: J Trace Elem Med Biol. 2015;31:249-59 (medline /25666158)
CM - Cites: Sci Total Environ. 2018 Jan 1;610-611:1239-1250 (medline /28851144)
CM - Cites: Annu Rev Microbiol. 2017 Sep 8;71:711-730 (medline /28731846)
CM - Cites: Appl Environ Microbiol. 2013 Jul;79(14):4325-35 (medline /23666325)
CM - Cites: Int J Phytoremediation. 2012 Jan;14(1):89-99 (medline /22567697)
CM - Cites: ISME J. 2011 Nov;5(11):1735-47 (medline /21562598)
CM - Cites: Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13479-84 (medline
/20624973)
CM - Cites: Plant Physiol. 2011 Jul;156(3):1631-8 (medline /21562336)
CM - Cites: Front Microbiol. 2014 Aug 29;5:465 (medline /25221550)
CM - Cites: PLoS One. 2012;7(7):e41305 (medline /22815990)
CM - Cites: J Appl Microbiol. 2015 Nov;119(5):1278-90 (medline /26348882)
CM - Cites: Bioresour Technol. 2011 Apr;102(8):5010-6 (medline /21333531)
CM - Cites: Biotechnol Bioeng. 2010 Apr 1;105(5):909-17 (medline /19953675)
CM - Cites: J Microbiol. 2013 Feb;51(1):11-7 (medline /23456706)
CM - Cites: J Ind Microbiol Biotechnol. 2016 Oct;43(10 ):1345-54 (medline
/27558781)
CM - Cites: Nat Biotechnol. 2011 May;29(5):415-20 (medline /21552244)
CM - Cites: Water Res. 2016 Sep 15;101:393-401 (medline /27288673)
CM - Cites: Appl Environ Microbiol. 2005 Oct;71(10):6319-24 (medline /16204553)
CM - Cites: Water Res. 2016 Dec 1;106:126-134 (medline /27705818)
CM - Cites: Appl Microbiol Biotechnol. 2018 Mar;102(5):2413-2424 (medline
/29380031)
CM - Cites: Mol Ecol. 2013 Oct;22(19):4870-83 (medline /23998659)
CM - Cites: Bioresour Technol. 2011 Oct;102(19):8756-61 (medline /21840210)
CM - Cites: PLoS Genet. 2007 Apr 13;3(4):e53 (medline /17432936)
CM - Cites: Science. 2008 Oct 10;322(5899):275-8 (medline /18845759)
CM - Cites: Sci Total Environ. 2012 Aug 15;432:113-21 (medline /22728298)
CM - Cites: J Environ Manage. 2016 Jun 1;174:14-25 (medline /26989941)
CM - Cites: Funct Integr Genomics. 2015 Mar;15(2):141-61 (medline /25722247)
CM - Cites: Environ Sci Pollut Res Int. 2017 Sep;24(27):21739-21749 (medline
/28766144)
CM - Cites: Science. 2002 Jun 21;296(5576):2143-5 (medline /12077387)
CM - Cites: MBio. 2015 Jan 27;6(1):null (medline /25626903)
CM - Cites: PLoS One. 2016 Jan 25;11(1):e0146832 (medline /26808278)
CM - Cites: Science. 1995 Jul 28;269(5223):496-512 (medline /7542800)
CM - Cites: Cell Mol Life Sci. 2015 Nov;72(22):4287-308 (medline /26254872)
CM - Cites: Water Res. 2008 Dec;42(19):4885-93 (medline /18929386)
CM - Cites: PLoS Comput Biol. 2016 Jul 11;12 (7):e1004977 (medline /27400279)
CM - Cites: Trends Microbiol. 2016 Jul;24(7):581-593 (medline /27050827)
CM - Cites: Methods Enzymol. 2013;531:237-50 (medline /24060124)
CM - Cites: Nat Commun. 2015 Dec 07;6:10008 (medline /26639611)
CM - Cites: Nat Rev Microbiol. 2005 Jun;3(6):479-88 (medline /15931166)
CM - Cites: Microb Inform Exp. 2012 Feb 09;2(1):3 (medline /22587947)
CM - Cites: Nature. 2005 Sep 22;437(7058):543-6 (medline /16177789)
CM - Cites: BMC Genomics. 2010 Dec 17;11:709 (medline /21167028)
CM - Cites: Int J Environ Res Public Health. 2015 Dec 22;13(1):ijerph13010062
(medline /26703687)
CM - Cites: Science. 2003 May 9;300(5621):939-44 (medline /12738852)
CM - Cites: Biotechnol Adv. 2015 Dec;33(8):1755-73 (medline /26409315)
CM - Cites: Syst Appl Microbiol. 2010 Apr;33(3):154-64 (medline /20303688)
CM - Cites: Curr Opin Biotechnol. 2016 Oct;41:114-121 (medline /27419912)
CM - Cites: BMC Microbiol. 2010 Feb 18;10:53 (medline /20167112)
CM - Cites: ISME J. 2018 Mar;12 (3):756-775 (medline /29222443)
CM - Cites: J Appl Microbiol. 2002;93(4):656-67 (medline /12234349)
CM - Cites: Curr Opin Biotechnol. 2011 Jun;22(3):456-64 (medline /21333523)
CM - Cites: Bioresour Technol. 2014 Mar;156:384-8 (medline /24507582)
CM - Cites: Genome Biol Evol. 2013;5(5):934-53 (medline /23589360)
CM - Cites: Brief Bioinform. 2012 Nov;13(6):728-42 (medline /22966151)
CM - Cites: Water Res. 2010 Sep;44(17):5098-108 (medline /20850864)
CM - Cites: Nature. 2006 Apr 6;440(7085):790-4 (medline /16598256)
CM - Cites: PLoS Genet. 2010 Feb 26;6(2):e1000859 (medline /20195515)
CM -Cites: Bioprocess Biosyst Eng. 2017 Feb;40(2):161-180 (medline /27738757)
CM -Cites: FEMS Microbiol Rev. 2016 Mar;40(2):299-322 (medline /26790947)
CM -Cites: Curr Opin Biotechnol. 2016 Oct;41:90-98 (medline /27344123)
CM -Cites: Brief Bioinform. 2017 Jun 9;:null (medline /28605403)
CM -Cites: J Environ Sci (China). 2011;23(9):1544-50 (medline /22432292)
CM -Cites: Stand Genomic Sci. 2010 Dec 25;3(3):243-8 (medline /21304727)
CM -Cites: Ecotoxicol Environ Saf. 2014 Sep;107:236-44 (medline /25011120)
CM -Cites: Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14500-5 (medline
/25246537)
CM - Cites: J Hazard Mater. 2014 Mar 30;269:89-97 (medline /24411461)
CM - Cites: Biometals. 2009 Feb;22(1):117-30 (medline /19130261)
CM - Cites: Nature. 2017 Nov 23;551(7681):457-463 (medline /29088705)
CM - Cites: Nat Commun. 2016 Oct 24;7:13219 (medline /27774985)
CM - Cites: Microb Biotechnol. 2017 Nov;10 (6):1500-1522 (medline /28925555)
CM - Cites: J Hazard Mater. 2008 May 1;153(1-2):588-99 (medline /17980486)
CM - Cites: Science. 2004 Apr 2;304(5667):66-74 (medline /15001713)
CM - Cites: Curr Opin Biotechnol. 2016 Oct;41:99-107 (medline /27314918)
CM - Cites: Bioresour Technol. 2017 Dec;245(Pt B):1304-1313 (medline /28533064)
CM - Cites: Sci Total Environ. 2011 May 15;409(12):2430-42 (medline /21459413)
CM - Cites: Environ Health Perspect. 2016 Jul;124(7):890-9 (medline /26587579)
CM - Cites: Biotechnol Adv. 2008 Nov-Dec;26(6):561-75 (medline /18725284)
CM - Cites: Nucleic Acids Res. 2017 Jan 4;45(D1):D446-D456 (medline /27794040)
CM - Cites: Res Microbiol. 2015 Apr;166(3):205-14 (medline /25753102)
CM - Cites: N Biotechnol. 2018 Jan 25;40(Pt A):144-153 (medline /28512003)
CM - Cites: Water Res. 2012 Oct 1;46(15):4825-31 (medline /22760058)
CM - Cites: Genome Announc. 2013 Oct 10;1(5):null (medline /24115546)
CM - Cites: Nucleic Acids Res. 2017 Jan 4;45(D1):D517-D528 (medline /27899624)
CM - Cites: Curr Opin Microbiol. 2017 Oct;39:136-142 (medline /29175703)
CM - Cites: Chemosphere. 2015 Nov;138:47-59 (medline /26037816)
CM - Cites: Appl Microbiol Biotechnol. 2007 Nov;77(2):457-67 (medline
/17846760)
DOCNO- medline/29755441

289 - TOXLINE
TI - Mutual interaction between arsenic and biofilm in a mining impacted river.
AU - Barral-Fraga L
AD - Institute of Aquatic Ecology, Department of Environmental Science, University
of Girona, Girona, Spain. Electronic address: laura.barral.fraga@gmail.com.
AU - Marti��-Prieto D
AD - Department of Soil Science and Agricultural Chemistry, Faculty of Pharmacy,
Campus Vida, University of Santiago de Compostela, Santiago de Compostela, Spain.
AU - Barral MT
AD - Department of Soil Science and Agricultural Chemistry, Faculty of Pharmacy,
Campus Vida, University of Santiago de Compostela, Santiago de Compostela, Spain.
AU - Morin S
AD - Irstea, UR EABX, Bordeaux, France.
AU - Guasch H
AD - Institute of Aquatic Ecology, Department of Environmental Science, University
of Girona, Girona, Spain.
SO - Sci Total Environ. 2018, Sep 15; 636:985-998. [The Science of the total
environment]
AB - Gold mining activities in fluvial systems may cause arsenic (As)
pollution, as is the case at the Anll�ns River (Galicia, NW Spain),
where high concentrations of arsenate (AsV) in surface sediments (up to
270&#8239;mg&#8239;kg-1) were found. A 51&#8239;day-long
biofilm-translocation experiment was performed in this river, moving some
biofilm-colonized substrata from upstream (less As-polluted) to downstream
the mine area (more As-polluted site), to explore the effect of As on
benthic biofilms, as well as their role on As retention and speciation in
the water-sediment interface. Eutrophic conditions (range:
0.07-0.38&#8239;mg&#8239;L-1 total phosphorus, TP) were detected in water
in both sites, while sediments were not considered P-polluted (below
600&#8239;mg&#8239;kg-1). Dimethylarsenate (DMAV) was found
intracellularly and in the river water, suggesting a detoxification
process by biofilms. Since most As in sediments and water was AsV, the
high amount of arsenite (AsIII) detected extracellularly may also confirm
AsV reduction by biofilms. Furthermore, translocated biofilms accumulated
more As and showed higher potential toxicity (higher As/P ratio). In
concordance, their growth was reduced to half that observed in those
non-translocated, became less nutritive (less nitrogen content), and with
higher bacterial and dead diatom densities. Besides the high As exposure,
other environmental conditions such as the higher riparian cover at the
more As-polluted site could contribute to those effects. Our study
provides new arguments to understand the contribution of microorganisms to
the As biogeochemistry in freshwater environments.
KW - Bacteria
KW - Biospeciation
KW - Diatoms
KW - Microalgae
KW - Microbial biogeochemistry
KW - Microbial ecotoxicology
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180615
CI - Copyright &copy; 2018 The Authors. Published by Elsevier B.V. All rights
reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180503
STAT- In-Process
DOCNO- medline/29729516

290 - TOXLINE
TI - Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217
regulation of EZH2, is involved in the malignant transformation of human
hepatic cells by accelerating the cell cycle and promoting cell
proliferation.
AU - Dai X
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Chen C
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Yang Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Xue J
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Chen X
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, 550025, Guizhou, People's Republic of China.
AU - Sun B
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, 550025, Guizhou, People's Republic of China.
AU - Luo F
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Liu X
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Xiao T
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Xu H
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Sun Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China.
AU - Zhang A
AD - The Key Laboratory of Environmental Pollution Monitoring and Disease Control,
Ministry of Education, School of Public Health, Guizhou Medical University,
Guiyang, 550025, Guizhou, People's Republic of China.
AU - Liu Q
AD - The Key Laboratory of Modern Toxicology, Ministry of Education, School of
Public Health, Nanjing Medical University, Nanjing, 211166, Jiangsu, People's
Republic of China. drqzliu@hotmail.com.
SO - Cell Death Dis. 2018, Apr 19; 9(5):454. [Cell death & disease]
AB - Intercellular communication between malignant cells and neighboring
nonmalignant cells is involved in carcinogenesis. In the progression of
carcinogenesis, exosomes are messengers for intercellular communication.
Circular RNAs (circRNAs) are noncoding RNAs with functions that include
regulation of the cell cycle and proliferation. However, the functions of
exosomal circRNAs are not clear. The present research aimed to determine
whether circRNAs secreted from arsenite-transformed human hepatic
epithelial (L-02) cells are transferred into normal L-02 cells and become
functionally active in the normal cells. The results showed that
circRNA_100284 is involved in the malignant transformation of L-02 cells
induced by arsenite. The medium from transformed L-02 cells induced
upregulation of circRNA_100284, accelerated the cell cycle, and promoted
proliferation of normal L-02 cells. Transformed cells transferred
circRNA_100284 into normal L-02 cells via exosomes and led to the
malignant transformation of the non-transformed cells. Knockdown of
circRNA_100284, which reduced circRNA_100284 levels in exosomes derived
from transformed L-02 cells, blocked the accelerated cell cycle and
reduced proliferation and malignancy. In addition, in normal L-02 cells,
exosomal circRNA_100284 derived from arsenite-transformed L-02 cells
induced acceleration of the cell cycle and promoted proliferation via
acting as a sponge of microRNA-217. Further, exosomal circRNA_100284 was
upregulated in the sera of people exposed to arsenite. Thus, exosomes
derived from transformed L-02 cells transferred circRNA_100284 to
surrounding cells, which induced an accelerated cell cycle and promoted
proliferation of normal liver cells and led to the malignant
transformation of the non-transformed cells. The findings support the
concept that exosomal circRNAs are involved in cell-cell communication
during carcinogenesis induced by arsenite.
LA - eng
IS - 2041-4889 (Electronic)
PT - Journal Article
TA - Cell Death Dis
YR - 2018
DATE- 20180606
CITO- NLM
CS - England
FJT - Cell death &amp; disease
EDAT- 20180419
STAT- In-Data-Review
CM - Cites: Toxicol Appl Pharmacol. 2013 Jan 15;266(2):187-97 (medline
/23194660)
CM - Cites: Toxicology. 2017 Mar 1;378:10-16 (medline /28069514)
CM - Cites: Carcinogenesis. 2016 Apr;37(4):385-96 (medline /26785732)
CM - Cites: Biochim Biophys Acta. 2015 Nov;1852(11):2362-71 (medline /26300484)
CM - Cites: Toxicol Lett. 2014 Jun 5;227(2):91-8 (medline /24704393)
CM - Cites: J Extracell Vesicles. 2015 Nov 11;4:28388 (medline /26563733)
CM - Cites: Cell Res. 2015 Aug;25(8):981-4 (medline /26138677)
CM - Cites: Oncotarget. 2015 May 10;6(13):10868-79 (medline /25869101)
CM - Cites: Arch Toxicol. 2012 Jun;86(6):947-59 (medline /22447124)
CM - Cites: Nat Cell Biol. 2007 Jun;9(6):654-9 (medline /17486113)
CM - Cites: Medicine (Baltimore). 2016 May;95(22):e3811 (medline /27258521)
CM - Cites: Toxicol Appl Pharmacol. 2015 Dec 1;289(2):276-85 (medline
/26415832)
CM - Cites: Toxicol Appl Pharmacol. 2016 Dec 1;312:11-18 (medline /26721309)
CM - Cites: Cancer Biomark. 2016;16(1):161-9 (medline /26600397)
CM - Cites: Br J Cancer. 2012 Jan 17;106(2):243-7 (medline /22187039)
CM - Cites: Methods. 2001 Dec;25(4):402-8 (medline /11846609)
CM - Cites: Biochim Biophys Acta. 2017 Mar;1863(3):753-763 (medline /28062277)
CM - Cites: Immunol Lett. 2006 Nov 15;107(2):102-8 (medline /17067686)
CM - Cites: J Clin Oncol. 2006 Jan 10;24(2):268-73 (medline /16330673)
CM - Cites: PLoS One. 2016 Feb 05;11(2):e0148407 (medline /26848835)
CM - Cites: Nature. 2014 Jun 26;510(7506):547-51 (medline /24870244)
CM - Cites: Free Radic Biol Med. 2012 May 1;52(9):1508-18 (medline /22387281)
CM - Cites: EMBO J. 2013 Apr 3;32(7):923-5 (medline /23463100)
CM - Cites: Environ Health Perspect. 2007 Apr;115(4):659-62 (medline /17450240)
CM - Cites: Toxicol Appl Pharmacol. 2013 Nov 15;273(1):27-34 (medline
/24004609)
CM - Cites: Sci Rep. 2016 Nov 28;6:37982 (medline /27892494)
CM - Cites: Cancer Cell. 2010 Oct 19;18(4):329-40 (medline /20951943)
CM - Cites: Oncol Rep. 2017 Mar;37(3):1772-1778 (medline /28184926)
CM - Cites: Front Oncol. 2014 Dec 19;4:361 (medline /25566500)
CM - Cites: Environ Health Perspect. 2015 Jan;123(1):A21 (medline /25561608)
CM - Cites: Am J Pathol. 2014 Jan;184(1):28-41 (medline /24269592)
CM - Cites: Pharmacol Rev. 2012 Jul;64(3):676-705 (medline /22722893)
CM - Cites: Environ Health Perspect. 2017 Aug 01;125(8):087001 (medline
/28796632)
CM - Cites: Cell Res. 2014 Jun;24(6):766-9 (medline /24710597)
CM - Cites: Nat Rev Immunol. 2015 Nov;15(11):669-82 (medline /26471778)
CM - Cites: Environ Toxicol Pharmacol. 2016 Apr;43:68-73 (medline /26970057)
CM - Cites: Cancer Lett. 2017 Mar 1;388:21-33 (medline /27913196)
CM - Cites: BMC Med Imaging. 2012 May 30;12:12 (medline /22647088)
CM - Cites: J Natl Cancer Inst. 2009 Dec 16;101(24):1670-81 (medline /19933942)
CM -Cites: Pathobiology. 2002;70(1):1-10 (medline /12415186)
CM -Cites: Nature. 2013 Mar 21;495(7441):384-8 (medline /23446346)
CM -Cites: Annu Rev Pathol. 2006;1:119-50 (medline /18039110)
CM -Cites: Cancer Lett. 2011 Nov 28;310(2):160-9 (medline /21802841)
CM -Cites: Oncotarget. 2016 Feb 2;7(5):5769-87 (medline /26735578)
CM -Cites: Arch Toxicol. 2015 Jul;89(7):1071-82 (medline /24912785)
CM -Cites: Cancer Lett. 2017 Jul 1;397:33-42 (medline /28288874)
CM -Cites: J Biol Chem. 2015 Feb 13;290(7):3925-35 (medline /25538231)
CM -Cites: Cancer Lett. 2016 Jan 1;370(1):125-35 (medline /26525579)
CM -Cites: J Hepatol. 2010 Jun;52(6):854-63 (medline /20395008)
CM -Cites: Cell. 2014 Sep 25;159(1):134-147 (medline /25242744)
CM -Cites: Toxicol Lett. 2010 Oct 5;198(2):263-71 (medline /20654705)
CM -Cites: Prog Nucleic Acid Res Mol Biol. 2005;79:237-97 (medline /16096030)
CM -Cites: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3427-31 (medline
/10097053)
CM - Cites: Environ Int. 2015 Aug;81:8-17 (medline /25898228)
CM - Cites: J Hepatol. 2015 Oct;63(4):874-85 (medline /25998163)
CM - Cites: Biochim Biophys Acta. 2016 Sep;1862(9):1685-95 (medline /27287256)
DOCNO- medline/29674685

291 - TOXLINE
TI - Long-term ongoing impact of arsenic contamination on the environmental
compartments of a former mining-metallurgy area.
AU - Gonz�lez-Fern�ndez B
AD - Dpto. de Explotaci�n y Prospecci�n de Minas, Universidad de Oviedo,
C/Independencia, 13, 33004 Oviedo, Asturias, Spain.
AU - Rodr�guez-Vald�s E
AD - INDUROT and Environmental Technology, Biotechnology and Geochemistry Group,
C/Gonzalo Guti�rrez Quir�s s/n, 33600 Mieres, Asturias, Spain.
AU - Boente C
AD - INDUROT and Environmental Technology, Biotechnology and Geochemistry Group,
C/Gonzalo Guti�rrez Quir�s s/n, 33600 Mieres, Asturias, Spain.
AU - Men�ndez-Casares E
AD - Dpto. de Explotaci�n y Prospecci�n de Minas, Universidad de Oviedo,
C/Independencia, 13, 33004 Oviedo, Asturias, Spain.
AU - Fern�ndez-Bra�a A
AD - INDUROT and Environmental Technology, Biotechnology and Geochemistry Group,
C/Gonzalo Guti�rrez Quir�s s/n, 33600 Mieres, Asturias, Spain.
AU - Gallego JR
AD - INDUROT and Environmental Technology, Biotechnology and Geochemistry Group,
C/Gonzalo Guti�rrez Quir�s s/n, 33600 Mieres, Asturias, Spain. Electronic address:
jgallego@uniovi.es.
SO - Sci Total Environ. 2018, Jan 01; 610-611:820-830. [The Science of the
total environment]
AB - Arsenic and mercury are potentially toxic elements of concern for soil,
surficial and ground waters, and sediments. In this work various
geochemical and hydrogeological tools were used to study a paradigmatic
case of the combined effects of the abandonment of Hg- and As-rich waste
on these environmental compartments. Continuous weathering of over 40years
has promoted As and Hg soil pollution (thousands of ppm) in the
surroundings of a former Hg mining-metallurgy site and affected the water
quality of a nearby river and shallow groundwater. In particular, the high
availability of As both in soils and waste was identified as one of the
main determinants of contaminant distribution, whereas the impact of Hg
was found to be minor, which is explained by lower mobility. Furthermore,
potential additional sources of pollution (coal mining, high natural
backgrounds, etc.) discharging into the study river were revealed less
significant than the contaminants generated in the Hg-mining area. The
transport and deposition of pollutants within the water cycle has also
affected several kilometres downstream of the release areas and the
chemistry of stream sediments. Overall, the environmental compartments
studies held considerable concentrations of Hg and As, as remarkably
revealed by the average contaminant load released in the river (several
tons of As per year) and the accumulation of toxic elements in sediments
(enrichment factors of As and Hg above 35).
KW - Arsenic
KW - Mercury
KW - Mining
KW - Sediment
KW - Soil
KW - Water pollution
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20170818
STAT- PubMed-not-MEDLINE
DOCNO- medline/28826120

292 - TOXLINE
TI - Chemical and toxicological assessment of arsenic sorption onto Fe-sericite
composite powder and beads.
AU - Kim J
AD - Division of Environmental Science and Ecological Engineering, Korea
University, Seoul 02841, Republic of Korea.
AU - Lee C
AD - Division of Environmental Science and Ecological Engineering, Korea
University, Seoul 02841, Republic of Korea.
AU - Lee SM
AD - Department of Environmental Engineering, Catholic Kwandong University,
Gangneung 25601, Republic of Korea.
AU - Lalhmunsiama
AD - Department of Environmental Engineering, Catholic Kwandong University,
Gangneung 25601, Republic of Korea.
AU - Jung J
AD - Division of Environmental Science and Ecological Engineering, Korea
University, Seoul 02841, Republic of Korea. Electronic address: jjung@korea.ac.kr.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:80-85. [Ecotoxicology and
environmental safety]
AB - Batch sorption and leaching of arsenic (1-30mgL-1) on Fe-sericite
composite powder and beads were investigated in this study. Fe-sericite
composite powder was made from natural sericite modified with iron, and
alginate was used to transform the powder into beads. The maximum sorption
capacities of the Fe-sericite composite powder (15.04 and 13.21mgg-1 for
As(III) and As(V), respectively) were higher than those of the
corresponding beads (9.02 and 7.11mgg-1 for As(III) and As(V),
respectively) owing to the higher specific surface area of the powder. In
addition, the leaching amounts of As(III) from Fe-sericite composite beads
(&le; 15.03%) were higher than those of the corresponding powder (&le;
5.71%). However, acute toxicity of As(III)-sorbed Fe-sericite composite
beads toward Daphnia magna was not significantly different from that of
the corresponding powder (p > 0.05). Considering higher uptake of the
powder particles by the daphnids, Fe-sericite composite beads seem to be a
more appropriate and safer sorbent for arsenic removal in practical
application. Based on Fe content, Fe-sericite composite beads had similar
or higher maximum sorption capacities (71.19 and 56.11mgg-1 Fe for As(III)
and As(V), respectively) than those of previously reported sorbents.
KW - Acute toxicity
KW - Adsorption
KW - Arsenic
KW - Sericite
KW - Sorbent
RN - 7631-86-9
RN - 8A5D83Q4RW
RN - 8C3Z4148WZ
RN - E1UOL152H7
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20170914
STAT- MEDLINE
DOCNO- medline/28837873

293 - TOXLINE
TI - Intake of arsenic and mercury from fish and seafood in a Northern Italy
community.
AU - Filippini T
AD - CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center
- Section of Public Health - Department of Biomedical, Metabolic and Neural
Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena,
Italy.
AU - Malavolti M
AD - CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center
- Section of Public Health - Department of Biomedical, Metabolic and Neural
Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena,
Italy.
AU - Cilloni S
AD - CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center
- Section of Public Health - Department of Biomedical, Metabolic and Neural
Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena,
Italy.
AU - Wise LA
AD - Department of Epidemiology, Boston University School of Public Health,
Boston, MA, USA.
AU - Violi F
AD - CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center
- Section of Public Health - Department of Biomedical, Metabolic and Neural
Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena,
Italy.
AU - Malagoli C
AD - CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center
- Section of Public Health - Department of Biomedical, Metabolic and Neural
Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena,
Italy.
AU - Vescovi L
AD - IREN, Reggio Emilia, Italy.
AU - Vinceti M
AD - CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center
- Section of Public Health - Department of Biomedical, Metabolic and Neural
Sciences, University of Modena and Reggio Emilia, 287 Via Campi, 41125 Modena,
Italy; Department of Epidemiology, Boston University School of Public Health,
Boston, MA, USA. Electronic address: marco.vinceti@unimore.it.
SO - Food Chem Toxicol. 2018, Jun; 116(Pt B):20-26. [Food and chemical
toxicology : an international journal published for the British Industrial
Biological Research Association]
AB - Regular consumption of fish is generally recommended by authorities
because fish is an important source of essential nutrients. However, the
presence of potentially toxic contaminants in fish has raised many
concerns about the food's safety for human health. In the present study,
we used a validated semi-quantitative food frequency questionnaire to
assess the dietary habits of a representative sample of 719 individuals
(319 males and 400 females) aged 18-87 years residing in Northern Italy.
We estimated weekly dietary intakes of Arsenic (As) and Mercury (Hg), and
we compared them with safety standards set by the European Food Safety
Authority. In this population, fish was the main contributor to As and Hg
intake. The highest levels of As were in sardine, sole/flounder and
cephalopods, and of Hg in the biggest, predatory fish. About the other
foods, cereals were the second contributor to the intake of these
elements, especially rice for As and bread for Hg, and high levels of As
and Hg were also found in mushrooms, coffee and wine. Average weekly
intake of both contaminants was below recommended safety limits.
KW - Arsenic
KW - Dietary intake
KW - Fish
KW - Food contamination
KW - Mercury
KW - Nutritional epidemiology
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180516
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180405
STAT- In-Process
DOCNO- medline/29626577

294 - TOXLINE
TI - Phosphate alleviates arsenate toxicity by altering expression of phosphate
transporters in the tolerant barley genotypes.
AU - Zvobgo G
AD - Department of Agronomy, College of Agriculture and Biotechnology, Key
Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR
China.
AU - LwalabaWaLwalaba J
AD - Department of Agronomy, College of Agriculture and Biotechnology, Key
Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR
China.
AU - Sagonda T
AD - Department of Agronomy, College of Agriculture and Biotechnology, Key
Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR
China.
AU - Mutemachani Mapodzeke J
AD - Department of Agronomy, College of Agriculture and Biotechnology, Key
Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR
China.
AU - Muhammad N
AD - Department of Agronomy, College of Agriculture and Biotechnology, Key
Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR
China.
AU - Haider Shamsi I
AD - Department of Agronomy, College of Agriculture and Biotechnology, Key
Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR
China.
AU - Zhang G
AD - Department of Agronomy, College of Agriculture and Biotechnology, Key
Laboratory of Crop Germplasm Resource, Zhejiang University, Hangzhou 310058, PR
China. Electronic address: zhanggp@zju.edu.cn.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:832-839. [Ecotoxicology and
environmental safety]
AB - The contribution of the phosphate transporters (PHTs) in uptake of
arsenate (As5+) and phosphate (P) is a widely recognized mechanism. Here
we investigated how P regulates the uptake of As5+ and the subsequent
effects on growth and relative expression of PHTs. The study was conducted
on 3 barley genotypes differing in As tolerance (ZDB160, As-tolerant;
ZDB115, moderately tolerant; ZDB475, As-sensitive) using a hydroponic
experiment. There were 3 As5+ (0, 10 and 100&micro;M) and 3P (0, 50 and
500&micro;M) levels. The results showed that the negative effect of As
stress on plant growth, photosynthesis and cell ultra-structure is As dose
and barley genotype dependent, confirming the distinctly genotypic
difference in As tolerance. As uptake and accumulation in plant tissues
are closely associated with inhibited extent of growth and photosynthesis,
with the tolerant genotype ZDB160 having lower As content than other two
genotypes. The toxic effect caused by As stress could be alleviated by P
addition, mainly due to reduced As uptake. Moreover, the tolerant genotype
showed relatively lower expression PHTs than sensitive ones upon exposure
to both As stress and P addition, suggesting regulation of PHTs expression
is a major mechanism for relative uptake of As and P, in subsequence
affecting As tolerance. Moreover, among 6 PHTs examined in this study, the
expressions of PHT1.3, PHT1.4 and PHT1.6 showed the marked difference
among the three barley genotypes in responses to As stress and P addition,
indicating further research on the contribution of phosphate transporters
to As and P uptake should be focused on these PHTs.
KW - Arsenate
KW - Phosphate
KW - Tolerance
KW - Toxicity
KW - Transporter
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180308
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20170926
STAT- MEDLINE
DOCNO- medline/28968924

295 - TOXLINE
TI - Essential micronutrient and toxic trace element concentrations in gluten
containing and gluten-free foods.
AU - Punshon T
AD - Department of Biological Sciences, Class of 1978 Life Sciences Center, 78
College Street, Dartmouth College, Hanover, NH 03755 USA. Electronic address:
tracy.punshon@dartmouth.edu.
AU - Jackson BP
AD - Department of Earth Sciences, 19 Fayerweather Hill Road, Dartmouth College,
Hanover, NH 03755 USA. Electronic address: bpj@dartmouth.edu.
SO - Food Chem. 2018, Jun 30; 252:258-264. [Food chemistry]
AB - For individuals following a gluten-free (GF) diet, rice is commonly the
major grain. People following a GF diet have a higher arsenic burden than
the general population. We conducted a multielemental market basket study
of GF and gluten containing ingredients and prepared foods (Mn, Fe, Ni,
Cu, Zn, Cr, Co, Se, Cd, Sb, Pb, total As, As species, total Hg and
methylmercury). Foods containing rice were significantly higher in As, Hg
and Pb and lower in Se, Fe, Cu and Zn. Wheat-based foods were higher in
Cd. Mercury concentrations were low ( < 3.5&#8239;ng/g); speciation was
predominantly methylmercury. Arsenic and mercury in rice were correlated.
GF foods contained significantly more As and Hg. Eating a wide variety of
GF grains may reduce contaminant exposure and increase micronutrient
status compared to a rice-based GF diet.
KW - Arsenic
KW - Gluten-free
KW - Market basket
KW - Mercury
KW - Rice
KW - Speciation
LA - eng
IS - 0308-8146 (Print)
PT - Journal Article
TA - Food Chem
YR - 2018
DATE- 20180303
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food chemistry
STAT- In-Process
CM - Cites: Sci Total Environ. 2017 Mar 1;581-582:209-220 (medline /28043702)
CM - Cites: J Anal At Spectrom. 2015 Jun 1;30(6):1405-1407 (medline /26366032)
CM - Cites: J Food Sci. 2014 Jan;79(1):T122-8 (medline /24313911)
CM - Cites: Clin Nutr. 2016 Dec;35(6):1236-1241 (medline /27211234)
CM - Cites: Environ Sci Technol. 2014 Jul 15;48(14):7974-81 (medline /24925231)
CM - Cites: Int J Hyg Environ Health. 2016 Nov;219(8):832-842 (medline
/27503636)
CM - Cites: Environ Res. 2014 Aug;133:407-23 (medline /24972509)
CM - Cites: Environ Res. 2016 Oct;150:519-27 (medline /27423706)
CM - Cites: Sci Total Environ. 2017 Feb 1;579:1228-1239 (medline /27914647)
CM - Cites: New Phytol. 2012 Feb;193(3):650-64 (medline /22142234)
CM - Cites: Environ Pollut. 2012 Apr;163:77-83 (medline /22325434)
CM - Cites: Environ Sci Technol. 2013 Jun 4;47(11):5613-8 (medline /23668419)
CM - Cites: Environ Health Perspect. 2000 Nov;108(11):1015-8 (medline
/11102289)
CM - Cites: Scand J Gastroenterol. 2013 Aug;48(8):921-5 (medline /23834276)
CM - Cites: Environ Sci Technol. 2008 Oct 1;42(19):7542-6 (medline /18939599)
CM - Cites: Clin Gastroenterol Hepatol. 2018 Feb;16(2):244-251 (medline
/28223206)
CM - Cites: Dig Dis. 2015;33(2):175-82 (medline /25925920)
CM - Cites: J Trace Elem Med Biol. 2015;31:130-4 (medline /25175507)
CM - Cites: Epidemiology. 2017 May;28(3):e24-e25 (medline /28166100)
CM - Cites: New Phytol. 2011 Oct;192(1):87-98 (medline /21658183)
CM - Cites: Anal Bioanal Chem. 2008 Dec;392(7-8):1283-90 (medline /18828006)
CM - Cites: BMC Plant Biol. 2004 Apr 14;4:4 (medline /15084224)
CM - Cites: Environ Res. 2017 Nov;159:639-647 (medline /28938205)
DOCNO- medline/29478539

296 - TOXLINE
TI - Synergistic arsenic(v) and lead(ii) retention on synthetic jarosite. I.
Simultaneous structural incorporation behaviour and mechanism.
AU - Aguilar-Carrillo J
AD - C�tedra CONACyT, Department of Environmental Technology, Institute of
Metallurgy, UASLP, 78210, San Luis Potos�, Mexico. jaguilarca@conacyt.mx.
AU - Villalobos M
AD - C�tedra CONACyT, Department of Environmental Technology, Institute of
Metallurgy, UASLP, 78210, San Luis Potos�, Mexico. jaguilarca@conacyt.mx.
AU - Pi-Puig T
AD - C�tedra CONACyT, Department of Environmental Technology, Institute of
Metallurgy, UASLP, 78210, San Luis Potos�, Mexico. jaguilarca@conacyt.mx.
AU - Escobar-Quiroz IN
AD - C�tedra CONACyT, Department of Environmental Technology, Institute of
Metallurgy, UASLP, 78210, San Luis Potos�, Mexico. jaguilarca@conacyt.mx.
AU - Romero FM
AD - C�tedra CONACyT, Department of Environmental Technology, Institute of
Metallurgy, UASLP, 78210, San Luis Potos�, Mexico. jaguilarca@conacyt.mx.
SO - Environ Sci Process Impacts. 2018, Feb 21; 20(2):354-369. [Environmental
science. Processes & impacts]
AB - Jarosite [KFe3(SO4)2(OH)6] minerals are effective scavengers of
potentially toxic elements (PTEs) and are abundant, for example, in acid
rock/mine drainage scenarios. The retention process is highly relevant for
environmental attenuation of heavy metals and metalloids since these are
usually highly soluble and thus mobile under acidic conditions. We
investigated both macroscopically and at the molecular scale the extent
and the effects of concomitant incorporation of As(v) and Pb(ii) into
synthetic jarosite at different As/Pb starting molar ratios, using
XRD-Rietveld, SEM, ATR-FTIR spectroscopy and wet chemistry. The amount of
arsenate substituted in the jarosite structure was larger when Pb(ii) was
also incorporated, the former filling up to approximately 33% of the
tetrahedral sites normally occupied by SO42-, as compared to 21% when
Pb(ii) was absent. Similarly, the amount of Pb(ii) incorporated in the
structure was larger when As(v) was also taken up. The jarosite unit cell
volume increased as higher amounts of As(v) incorporated into its
structure, but simultaneous Pb(ii) incorporation seemed to limit this
increase due to its smaller size as compared to K+. The extent to which As
and Pb can accommodate in the jarosite structure was found to be limited
by concentration maxima under the imposed synthesis conditions. At As/Pb
ratios up to 1, Pb-As-jarosites were the only crystalline products. Above
this ratio, a mixture of Pb-As-jarosite, anglesite (PbSO4) and
poorly-crystalline ferric arsenate (AFA) phases was observed. At the
highest As/Pb ratio investigated of 1.80 Pb-As-jarosite was no longer
formed. Infrared spectroscopy analysis was applied for the first time here
to substituted jarosites with both cations and anions, showing spectral
changes in the solids as the As/Pb ratio increased: a characteristic As-O
doublet at &sim;810 and &sim;855 cm-1 was observed upon Pb incorporation,
showing an indirect effect of Pb(ii) on the As-O bonds in the jarosite
structure. Thus, structural incorporation of Pb plays a pivotal role in
the unit cell environment of jarosite to balance the distortion caused by
AsO4-for-SO4 substitution. The retention processes found in this work have
important environmental implications and impacts: through the synergistic
incorporation encountered, remediation enhancement of cationic pollutants
such as Pb(ii) is possible in a concomitant fashion with As(v) attenuation
in acidic mining and metallurgical environments.
RN - 2P299V784P
RN - N712M78A8G
LA - eng
IS - 2050-7895 (Electronic)
PT - Journal Article
TA - Environ Sci Process Impacts
YR - 2018
DATE- 20180604
CITO- NLM
CS - England
CSET- IM
FJT - Environmental science. Processes &amp; impacts
STAT- MEDLINE
DOCNO- medline/29226929

297 - TOXLINE
TI - Changes in Arsenic, Copper, Iron, Manganese, and Zinc Levels Resulting
from the Application of Poultry Litter to Agricultural Soils.
AU - Foust RD
AD - Department of Chemistry and Biochemistry, James Madison University,
Harrisonburg, VA 22807, USA. foustrd@jmu.edu.
AU - Phillips M
AD - Natural Resources Conservation Service, Virginia, United States Department of
Agriculture, Harrisonburg, VA 22801, USA. mike.phillips@va.usda.gov.
AU - Hull K
AD - Department of Chemistry and Biochemistry, James Madison University,
Harrisonburg, VA 22807, USA. killian.hull@gmail.com.
AU - Yehorova D
AD - Department of Chemistry and Biochemistry, James Madison University,
Harrisonburg, VA 22807, USA. yehorodx@dukes.jmu.edu.
SO - Toxics. 2018, May 14. [Toxics]
AB - Twelve applications of poultry litter were made to a 2.1-ha field located
in the Shenandoah Valley of Virginia, United States (USA), between March
1999 and August 2014. The field was planted with bermudagrass (Cynodon
dactylon) and used as a pasture on an active farm. Copper, iron,
manganese, zinc, and arsenic concentrations in the poultry litter were
measured, and the application rates of these metals were calculated. The
median application rates were: Cu, 1.32 kg/ha, Fe, 5.57 kg/ha, Mn, 1.80
kg/ha, Zn, 1.39 kg/ha, and As, 0.011 kg/ha. Twelve surface and subsurface
soil samples were taken from the treated field in February 2016. Twelve
samples were also taken from a comparison site. The comparison site was
directly adjacent to the study site, consisted of the same soil type, and
had been maintained as an undisturbed forest. Extractable Cu, Fe, Mn, Zn,
and As concentrations in the soil samples were determined by atomic
absorption spectroscopy, and the results of the chemical analysis were
analyzed by ANOVA. Fe and Mn were depleted from the soil in the treated
field, while Cu and Zn levels increased over the 12 years of treatment and
grazing, and arsenic levels were unchanged in both the surface and
subsurface soils between the comparison and the study site. The changes
observed for Cu, Fe, Mn, and Zn are within the critical deficiency level
and critical toxicity level for these metals, and no arsenic remains in
the soil from roxarsone feed supplements, which were added to the poultry
feed when the litter was applied to the study site.
COI - The authors declare no conflict of interest.
KW - Cynodon dactylon
KW - arsenic
KW - copper
KW - iron
KW - manganese
KW - poultry litter
KW - soil
KW - zinc
LA - eng
IS - 2305-6304 (Electronic)
PT - Journal Article
TA - Toxics
YR - 2018
DATE- 20180514
CITO- NLM
CS - Switzerland
FJT - Toxics
EDAT- 20180514
STAT- PubMed-not-MEDLINE
DOCNO- medline/29757950

298 - TOXLINE
TI - Absorption of arsenic from soil and water by two chard (Beta vulgaris L.)
varieties: A potential risk to human health.
AU - Ya�ez LM
AD - Facultad de Ciencias Agrarias, Universidad Nacional de Jujuy, Alberdi N&ordm;
47, 4600, San Salvador de Jujuy, Argentina; C�tedra Toxicolog�a de los Alimentos,
Facultad de Ciencias Agrarias, Universidad Nacional de Jujuy, Alberdi N&ordm; 47,
4600, San Salvador de Jujuy, Argentina. Electronic address: lumaya12@hotmail.com.
AU - Alfaro JA
AD - Facultad de Ciencias Agrarias, Universidad Nacional de Jujuy, Alberdi N&ordm;
47, 4600, San Salvador de Jujuy, Argentina.
AU - Bovi Mitre G
AD - Facultad de Ciencias Agrarias, Universidad Nacional de Jujuy, Alberdi N&ordm;
47, 4600, San Salvador de Jujuy, Argentina; C�tedra Toxicolog�a de los Alimentos,
Facultad de Ciencias Agrarias, Universidad Nacional de Jujuy, Alberdi N&ordm; 47,
4600, San Salvador de Jujuy, Argentina.
SO - J Environ Manage. 2018, Jul 15; 218:23-30. [Journal of environmental
management]
AB - The accumulation of arsenic (As) in vegetables poses a risk of
contamination to humans via the food chain. Two chard (var. cicla and var.
d'ampuis) crops were grown for 60 days in greenhouses on Aridisol soil,
and irrigated with water from Pastos Chicos, Jujuy (Argentina). The soil
and water used in the trial presented 49 and 1.44&#8239;mg/L As
concentration levels, respectively. Total dry biomass (TDB) and total As
were determined in soils, roots and leaves. The latter was quantified by
atomic absorption spectrometry with hydride generation, and
bioconcentration and translocation factors were determined. TDB in var.
cicla showed statistically significant differences when the plant was
cultivated in control soil and watered with the toxicant (2.04&#8239;g),
as compared with the treatment without exposure (2.8&#8239;g). TDB in var.
d'ampuis presented statistically significant differences with respect to
that of the control when the plants were grown in soils with As and
watered with the toxicant (3.3&#8239;g). This variety increased its
biomass in the presence of As. In the two Swiss chard varieties evaluated,
the largest As accumulation in root and leaves was found when they were
cultivated in contaminated soil and watered with distilled water. The
presence of the toxicant in the leaves exceeded the limits established by
C�digo Alimentario Argentino, i.e. 0.30&#8239;mg/kg. Total target
hazard quotient (THQ) values for As were higher than 1, suggesting that
consumers would run significant risks when consuming these chard
varieties. Furthermore, it was determined that the carcinogenic risk (CR)
posed by this type of exposure to As exceeded the acceptable risk level of
1&#8239;&times;&#8239;10-6. Based on this evidence, we may conclude that
consuming chard cultivated on the evaluated site brings about considerable
risks to local residents' health.
KW - Argentina
KW - Arsenic
KW - Chard
KW - Food risk
KW - Jujuy
KW - Target hazard quotient
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180514
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180414
STAT- In-Process
DOCNO- medline/29665483

299 - TOXLINE
TI - Concentrations of arsenic and lead in rice (Oryza sativa L.) in Iran: A
systematic review and carcinogenic risk assessment.
AU - Fakhri Y
AD - Department of Environmental Health Engineering, Student Research Committee,
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran,
Iran. Electronic address: YA.FAKHRI@Sbmu.ac.ir.
AU - Bj�rklund G
AD - Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
Electronic address: bjorklund@conem.org.
AU - Bandpei AM
AD - Environmental and Occupational Hazards Control Research Center, Shahid
Beheshti University of Medical Sciences, Tehran, Iran.
AU - Chirumbolo S
AD - Department of Neurological and Movement Sciences, University of Verona,
Italy.
AU - Keramati H
AD - Department of Environmental Health Engineering, School of Public Health,
Semnan University of Medical Sciences, Semnan, Iran.
AU - Hosseini Pouya R
AD - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar
Abbas, Iran.
AU - Asadi A
AD - Research Center for Environmental Determinants of Health (RCEDH), Kermanshah
University of Medical Sciences, Kermanshah, Iran.
AU - Amanidaz N
AD - Environmental Health Research Center, Golestan University of Medical
Sciences, Golestan, Iran.
AU - Sarafraz M
AD - Department of Environmental Health Engineering, Student Research Committee,
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran,
Iran.
AU - Sheikhmohammad A
AD - Department of Environmental health, University of Khoy, Khoy, Iran.
AU - Alipour M
AD - Environmental and Occupational Hazards Control Research Center, Shahid
Beheshti University of Medical Sciences, Tehran, Iran.
AU - Baninameh Z
AD - Sina Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AU - Mohseni SM
AD - Department of Environmental Health Engineering, School of Public Health, Qom
University of Medical Sciences, Qom, Iran.
AU - Sarkhosh M
AD - Department of Environmental Health Engineering, School of Health, Mashhad
University of Medical Sciences, Mashhad, Iran.
AU - Ghasemi SM
AD - Deputy of Health, Babol University of Medical Sciences, Babol, Iran.
SO - Food Chem Toxicol. 2018, Mar; 113:267-277. [Food and chemical toxicology :
an international journal published for the British Industrial Biological
Research Association]
AB - Exposure to heavy metals such as arsenic (As), lead (Pb), and cadmium (Cd)
in either the short or the long term can cause cancers in humans. Dietary
intake and consumption of rice (Oryza sativa L.) is increasing in Iran,
and several studies on the concentration of heavy metals in rice have been
carried out in this country in recent years. In this perspective, the main
objective of the present study was to investigate, even via a
meta-analysis of the existing literature, the presence of As and Pb in
rice from many geographical areas in Iran, as well as to estimate the
carcinogenic risk of these heavy metals in rice consumers. The results of
the present ten years-spanning systematic review indicate that 21 reports,
collecting a total of 2088 samples, were performed between 2008 and
October 2017. The minimum and maximum concentration of As was observed in
the Golestan area (0.01&#8239;&plusmn;&#8239;0.01&#8239;mg/kg d.w) and the
Gillan region (3&#8239;mg/kg d.w); and Pb in the Shahrekord
(0.07&#8239;&plusmn;&#8239;0.02&#8239;mg/kg d.w) and Mazandaran
(35&#8239;mg/kg d.w). The meta-analysis of data showed that pooled
concentration of As in the rice was 0.04 (95%CI: 0.02-0.06&#8239;mg/kg
d.w), which resulted lower than the National Standard (NS) limits.
However, the pooled concentration of Pb in the rice was 0.38 (95%CI:
0.25-0.5&#8239;mg/kg d.w), i.e., higher than NS limits. The heterogeneity
was significant between As (I2&#8239;=&#8239;63%, P
value&#8239;=&#8239;.003) and Pb (I2&#8239;=&#8239;96%, P
value&#8239; < &#8239;.001) studies. The carcinogenic risk assessment
showed that minimum and maximum incremental lifetime cancer risk (ILCR) of
As was in the 45-54 (4.53&#8239;&times;&#8239;10-2) and 15-24
(5.50&#8239;&times;&#8239;10-2) year age groups consumers; and Pb, 45-54
(2.442&#8239;&times;&#8239;10-3) and 15-24
(2.96&#8239;&times;&#8239;10-3), respectively. The overall carcinogenesis
risk of As (4.864&#8239;&times;&#8239;10-2) was 18.5 times higher than Pb
(2.623&#8239;&times;&#8239;10-3). All age groups consumers of rice content
of As and Pb are at considerable carcinogenesis risk
(ILCR&#8239; > &#8239;10-3). Therefore a decreased level of heavy metals
in rice cultivation should be encouraged and performed in next planning.
KW - Arsenic
KW - Carcinogenic risk
KW - Heavy metals
KW - Iran
KW - Lead
KW - Oryza sativa L
KW - Rice
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180228
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180116
STAT- In-Process
DOCNO- medline/29341878

300 - TOXLINE
TI - Structure of an As(III) S-adenosylmethionine methyltransferase with
3-coordinately-bound As(III) depicts the first step in catalysis.
AU - Packianathan C
AU - Kandavelu P
AU - Rosen BP
SO - Biochemistry. 2018, Jun 12. [Biochemistry]
AB - Arsenic is a ubiquitous environmental toxic substance and a Class 1 human
carcinogen. Arsenic methylation by the enzyme As(III) S-adenosylmethionine
(SAM) methyltransferase (ArsM in microbes or AS3MT in animals) detoxifies
As(III) in microbes but transforms it into more toxic and potentially more
carcinogenic methylated species in humans. We previously proposed a
reaction pathway for ArsM/AS3MT that involves initial 3-coordinate binding
of As(III). To date reported structures have had only 2-coordinately bound
trivalent arsenicals. Here we report a crystal structure of CmArsM from
Cyanidioschyzon merolae in which As(III) is 3-coordinately bound to three
conserved cysteine residues with a molecule of the product
S-adenosyl-L-homocysteine (SAH) bound in the SAM binding site. We propose
that this structure represents the first step in the catalytic cycle. In a
previously-reported SAM-bound structure a disulfide bond is formed between
two conserved cysteine residues. Comparison of these two structures
indicates that there is a conformational change in the N-terminal domain
of CmArsM that moves a loop to allow formation of the 3-coordiate As(III)
binding site. We propose that this conformational change is an initial
step in the ArsM catalytic cycle.
LA - eng
IS - 1520-4995 (Electronic)
PT - Journal Article
TA - Biochemistry
YR - 2018
DATE- 20180612
CITO- NLM
CS - United States
FJT - Biochemistry
EDAT- 20180612
STAT- Publisher
DOCNO- medline/29894638
301 - TOXLINE
TI - Influence of age on arsenic-induced behavioral and cholinergic
perturbations: Amelioration with zinc and &alpha;-tocopherol.
AU - Kumar MR
AD - 1 Department of Zoology, Sri Venkateswara University, Tirupati, Andhra
Pradesh, India.
AU - Reddy GR
AD - 1 Department of Zoology, Sri Venkateswara University, Tirupati, Andhra
Pradesh, India.
SO - Hum Exp Toxicol. 2018, Mar; 37(3):295-308. [Human & experimental
toxicology]
AB - This study was planned to determine arsenic (As) (10 mg/kg body weight
given through oral gavage) induced behavioral and cholinergic
perturbations in three different age groups of rats; young (postnatal day
21), adult (3 months), and aged (18 months) at 7 days post-acute exposure
( n = 6 for each of the four groups of all three age points). Further, we
also evaluated the ameliorative effect of essential metal zinc (Zn; 0.02%
through drinking water) and an antioxidant, &alpha;-tocopherol (vitamin E;
125 mg/kg body weight through oral gavage) against As-induced
neurotoxicity. As exposure showed significant alterations in behavioral
functions (open-field behavior, total locomotor activity, grip strength,
exploratory behavior, and water maze learning). Cholinergic studies in
three brain regions (cerebral cortex, cerebellum, and hippocampus) of
different age groups also showed significant increase in acetylcholine
levels and a decrease in acetylcholinesterase activity. These effects were
more pronounced in hippocampus followed by cerebral cortex and cerebellum.
Among the three different age points, aged animals were found to be more
vulnerable to the As-induced toxicity as compared to young and adult
animals suggesting that As neurotoxicity is age dependent. These
As-induced alterations were significantly reversed following
supplementation with Zn or vitamin E. However, vitamin E was found to
elicit greater protection as compared to Zn in restoring the altered
behavioral and cholinergic perturbations, providing evidence for
As-induced oxidative damage.
KW - Arsenic
KW - age
KW - behavior
KW - cholinergic system
KW - vitamin E
KW - zinc
LA - eng
IS - 1477-0903 (Electronic)
PT - Journal Article
TA - Hum Exp Toxicol
YR - 2018
DATE- 20180123
CITO- NLM
CS - England
FJT - Human &amp; experimental toxicology
EDAT- 20170323
STAT- In-Process
DOCNO- medline/29233033

302 - TOXLINE
TI - Selective inhibition of CTCF binding by iAs directs TET-mediated
reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells.
AU - Rea M
AD - Department of Molecular and Cellular Biochemistry, University of Kentucky,
Lexington, KY 40536, USA.
AU - Gripshover T
AD - Department of Molecular and Cellular Biochemistry, University of Kentucky,
Lexington, KY 40536, USA; Eastern Kentucky University, Richmond, KY 40475, USA.
AU - Fondufe-Mittendorf Y
AD - Department of Molecular and Cellular Biochemistry, University of Kentucky,
Lexington, KY 40536, USA. Electronic address: y.fondufe-mittendorf@uky.edu.
SO - Toxicol Appl Pharmacol. 2018, 01 01; 338:124-133. [Toxicology and applied
pharmacology]
AB - Methylation at cytosine (5mC) is a fundamental epigenetic DNA modification
recently associated with iAs-mediated carcinogenesis. In contrast, the
role of 5-hydroxymethylcytosine (5hmC), the oxidation product of 5mC in
iAs-mediated carcinogenesis is unknown. Here we assess the
hydroxymethylome in iAs-transformed cells, showing that dynamic modulation
of hydroxymethylated DNA is associated with specific transcriptional
networks. Moreover, this pathologic iAs-mediated carcinogenesis is
characterized by a shift toward a higher hydroxymethylation pattern
genome-wide. At specific promoters, hydroxymethylation correlated with
increased gene expression. Furthermore, this increase in
hydroxymethylation occurs concurrently with an upregulation of ten-eleven
translocation (TET) enzymes that oxidize 5-methylcytosine (5mC) in DNA. To
gain an understanding into how iAs might impact TET expression, we found
that iAs inhibits the binding of CTCF at the proximal, weak CTCF binding
sites of the TET1 and TET2 gene promoters and enhances CTCF binding at the
stronger distal binding site. Further analyses suggest that this distal
site acts as an enhancer, thus high CTCF occupancy at the enhancer region
of TET1 and TET2 possibly drives their high expression in iAs-transformed
cells. These results have major implications in understanding the impact
of differential CTCF binding, genome architecture and its consequences in
iAs-mediated pathogenesis.
KW - *5hmC
KW - *EMT
KW - *Epigenetics
KW - *Inorganic arsenic
KW - *RRHP
KW - *TET
RN - 1123-95-1
RN - 6R795CQT4H
RN - EC 1.-
RN - EC 1.-
RN - N712M78A8G
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
PT - Research Support, N.I.H., Extramural
PT - Research Support, U.S. Gov't, Non-P.H.S.
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180213
CI - Copyright &copy; 2017. Published by Elsevier Inc.
CITO- NLM
CS - United States
CSET- IM
FJT - Toxicology and applied pharmacology
EDAT- 20171122
STAT- MEDLINE
CM - Cites: Nat Genet. 2007 Mar;39(3):311-8 (medline /17277777)
CM - Cites: Scand J Gastroenterol. 2017 Mar;52(3):312-320 (medline /27846738)
CM - Cites: Nat Biotechnol. 2009 Apr;27(4):361-8 (medline /19329998)
CM - Cites: PLoS One. 2010 Dec 23;5(12):e15367 (medline /21203455)
CM - Cites: Oncotarget. 2012 Apr;3(4):462-74 (medline /22577155)
CM - Cites: Nat Rev Genet. 2017 Sep;18(9):517-534 (medline /28555658)
CM - Cites: Stem Cell Res. 2014 May;12 (3):791-806 (medline /24751885)
CM - Cites: Genome Biol. 2014 Dec 03;15(12 ):513 (medline /25517638)
CM - Cites: Science. 2011 Sep 2;333(6047):1303-7 (medline /21817016)
CM - Cites: Genome Res. 2012 Feb;22(2):246-58 (medline /22156296)
CM - Cites: Proc Natl Acad Sci U S A. 2010 May 11;107(19):8689-94 (medline
/20395551)
CM - Cites: Genome Biol. 2014 Sep 24;15(9):456 (medline /25248841)
CM - Cites: Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14631-6 (medline
/25246589)
CM - Cites: Clin Chem. 2013 May;59(5):824-32 (medline /23344498)
CM - Cites: Science. 2013 Nov 8;342(6159):750-2 (medline /24136358)
CM - Cites: Cell Res. 2016 Jan;26(1):103-18 (medline /26680004)
CM - Cites: Cell Stem Cell. 2014 Apr 3;14(4):512-22 (medline /24529596)
CM - Cites: Nat Genet. 2011 Nov 27;44(1):40-6 (medline /22120008)
CM - Cites: BMC Genomics. 2015 Mar 19;16:212 (medline /25879800)
CM - Cites: Environ Health Perspect. 2011 Jan;119(1):11-9 (medline /20682481)
CM - Cites: Cell. 1999 Oct 29;99(3):247-57 (medline /10555141)
CM - Cites: Epigenetics. 2014 Apr;9(4):503-12 (medline /24441198)
CM - Cites: Nature. 2013 Oct 24;502(7472):472-9 (medline /24153300)
CM - Cites: Toxicol Sci. 2015 Jan;143(1):97-106 (medline /25304211)
CM - Cites: Cell. 2012 Jun 8;149(6):1368-80 (medline /22608086)
CM - Cites: Nat Rev Genet. 2002 Jun;3(6):415-28 (medline /12042769)
CM - Cites: Mol Cell Biochem. 2004 Jan;255(1-2):57-66 (medline /14971646)
CM - Cites: J Biol Chem. 2011 Jul 1;286(26):22855-63 (medline /21550982)
CM - Cites: Plant Cell. 2006 Apr;18(4):805-14 (medline /16531498)
CM - Cites: Rev Environ Health. 2017 Mar 1;32(1-2):93-103 (medline /27701139)
CM - Cites: Genomics. 2014 Nov;104(5):324-33 (medline /25173569)
CM - Cites: Genes Dev. 2002 Jan 1;16(1):6-21 (medline /11782440)
CM - Cites: Nucleic Acids Res. 2013 Jan;41(Database issue):D793-800 (medline
/23143270)
CM - Cites: BMC Genomics. 2008 Dec 24;9:633 (medline /19108745)
CM - Cites: Biomedicine (Taipei). 2016 Mar;6(1):1 (medline /26869355)
CM - Cites: J Clin Med. 2016 Feb 04;5(2):null (medline /26861406)
CM - Cites: Nature. 2012 Sep 6;489(7414):101-8 (medline /22955620)
CM - Cites: Science. 2011 Sep 2;333(6047):1300-3 (medline /21778364)
CM - Cites: Science. 2012 May 18;336(6083):934-7 (medline /22539555)
CM - Cites: Chem Res Toxicol. 2008 Jan;21(1):28-44 (medline /17970581)
CM - Cites: Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14682-7 (medline
/23969834)
CM - Cites: Cancer Biol Ther. 2014 Jan;15(1):10-5 (medline /24253310)
CM - Cites: Cell. 2011 Jul 8;146(1):67-79 (medline /21722948)
CM - Cites: Nucleic Acids Res. 2008 Jan;36(Database issue):D83-7 (medline
/17981843)
CM - Cites: Mol Cell Proteomics. 2016 Jul;15(7):2411-22 (medline /27169413)
CM - Cites: Genome Biol. 2012 Oct 23;13(10):173 (medline /23092522)
CM - Cites: Genome Biol. 2014 Jun 23;15(6):R81 (medline /24958354)
CM - Cites: Transcription. 2011 Nov-Dec;2(6):263-8 (medline /22223044)
CM - Cites: PLoS One. 2012;7(8):e43880 (medline /22952798)
CM - Cites: Science. 2004 Jan 23;303(5657):521-3 (medline /14631047)
CM - Cites: Nucleic Acids Res. 2010 Jan;38(Database issue):D792-9 (medline
/19906719)
CM - Cites: Biochem Biophys Res Commun. 2013 Aug 2;437(3):368-73 (medline
/23820384)
CM - Cites: Nat Rev Genet. 2012 May 29;13(7):484-92 (medline /22641018)
CM - Cites: Nucleic Acids Res. 2013 Jan;41(Database issue):D188-94 (medline
/23193294)
CM - Cites: PLoS One. 2010 Jan 26;5(1):e8888 (medline /20126651)
CM -Cites: Nat Chem. 2014 Dec;6(12):1049-55 (medline /25411882)
CM -Cites: Plant J. 2012 Sep;71(5):776-86 (medline /22519754)
CM -Cites: Epigenetics. 2015 ;10 (9):819-33 (medline /26186463)
CM -Cites: Nature. 2000 Feb 3;403(6769):501-2 (medline /10676950)
CM -Cites: Oncotarget. 2015 Aug 28;6(25):21493-506 (medline /26046465)
CM -Cites: Sci Rep. 2017 Feb 02;7:41474 (medline /28150704)
CM -Cites: N Engl J Med. 2003 Nov 20;349(21):2042-54 (medline /14627790)
CM -Cites: J Appl Toxicol. 2012 Sep;32(9):643-53 (medline /22334439)
CM -Cites: Cell Rep. 2013 May 30;3(5):1678-1689 (medline /23707059)
CM -Cites: Toxicol Appl Pharmacol. 2017 Sep 15;331:6-17 (medline /28336213)
CM -Cites: Cell Stem Cell. 2014 Oct 2;15(4):447-459 (medline /25220291)
CM -Cites: Genome Res. 2012 Mar;22(3):467-77 (medline /22106369)
CM -Cites: PLoS One. 2010 Nov 08;5(11):e13872 (medline /21079786)
CM -Cites: Epigenetics Chromatin. 2016 May 31;9:21 (medline /27252783)
CM -Cites: Nucleic Acids Res. 2011 Jan;39(Database issue):D712-7 (medline
/21071422)
CM - Cites: Curr Opin Genet Dev. 2016 Apr;37:17-26 (medline /26802288)
CM - Cites: BMC Genomics. 2015 Aug 20;16:624 (medline /26290333)
CM - Cites: Metallomics. 2009;1(3):222-8 (medline /20461219)
CM - Cites: Epigenetics Chromatin. 2017 Apr 20;10 :16 (medline /28428825)
DOCNO- medline/29175454

303 - TOXLINE
TI - Health risk assessment of drinking arsenic-containing groundwater in
Hasilpur, Pakistan: effect of sampling area, depth, and source.
AU - Tabassum RA
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, 61100, Pakistan.
AU - Shahid M
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, 61100, Pakistan. muhammadshahid@ciitvehari.edu.pk.
AU - Dumat C
AD - Centre d'Etude et de Recherche Travail Organisation Pouvoir (CERTOP),
UMR5044, Universit� J. Jaur�s - Toulouse II, 5 all�e Antonio Machado, 31058,
Toulouse Cedex 9, France.
AU - Niazi NK
AD - Southern Cross GeoScience, Southern Cross University, Lismore, NSW, 2480,
Australia.
AU - Khalid S
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, 61100, Pakistan.
AU - Shah NS
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, 61100, Pakistan.
AU - Imran M
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, 61100, Pakistan.
AU - Khalid S
AD - Department of Environmental Sciences, COMSATS Institute of Information
Technology, Vehari, 61100, Pakistan.
SO - Environ Sci Pollut Res Int. 2018, Feb 10. [Environmental science and
pollution research international]
AB - Currently, several news channels and research publications have
highlighted the dilemma of arsenic (As)-contaminated groundwater in
Pakistan. However, there is lack of data regarding groundwater As content
of various areas in Pakistan. The present study evaluated As contamination
and associated health risks in previously unexplored groundwater of
Hasilpur-Pakistan. Total of 61 groundwater samples were collected from
different areas (rural and urban), sources (electric pump, hand pump, and
tubewell) and depths (35-430 ft or 11-131 m). The water samples
were analyzed for As level and other parameters such as pH, electrical
conductivity, total dissolved solids, cations, and anions. It was found
that 41% (25 out of 61) water samples contained As
(&ge;&thinsp;5 &mu;g/L). Out of 25 As-contaminated water samples, 13
water samples exceeded the permissible level of WHO (10 &mu;g/L).
High As contents have been found in tubewell samples and at high sampling
depths ( > &thinsp;300 ft). The major As-contaminated groundwater in
Hasilpur is found in urban areas. Furthermore, health risk and cancer risk
due to As contamination were also assessed with respect to average daily
dose (ADD), hazard quotient (HQ), and carcinogenic risk (CR). The values
of HQ and CR of As in Hasilpur were up to 58 and 0.00231, respectively.
Multivariate analysis revealed a positive correlation between groundwater
As contents, pH, and depth in Hasilpur. The current study proposed the
proper monitoring and management of well water in Hasilpur to minimize the
As-associated health hazards.
KW - Arsenic
KW - Drinking water
KW - Groundwater
KW - Hasilpur
KW - Risk assessment
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180211
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180210
STAT- Publisher
DOCNO- medline/29429111

304 - TOXLINE
TI - Perinatal Exposure to Arsenic in Drinking Water Alters Glutamatergic
Neurotransmission in the Striatum of C57BL/6 Mice.
AU - Sung K
AD - Collage of Pharmacy, Keimyung University, Daegu, 42601, Republic of Korea.
AU - Kim M
AD - Collage of Pharmacy, Ewha Woman's University, Seoul, 03760, Republic of
Korea.
AU - Kim H
AD - Collage of Pharmacy, Keimyung University, Daegu, 42601, Republic of Korea.
AU - Hwang GW
AD - Laboratory of Molecular and Biochemical Toxicology, Graduate School of
Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
AU - Kim K
AD - Laboratory of Molecular and Biochemical Toxicology, Graduate School of
Pharmaceutical Sciences, Tohoku University, Sendai, 980-8578, Japan.
kimkisok@kmu.ac.kr.
SO - Biol Trace Elem Res. 2018, May 10. [Biological trace element research]
AB - Although exposure to arsenic (As) induces developmental neurotoxicity,
there is a lack of data regarding its specific effects on glutamatergic
neurotransmission in offspring from dams exposed to As during gestation
and lactation. In this study, the body weight, glutamate content, and
expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic
glutamate receptors mGluR2 and mGluR3 was examined in the striatum of
offspring following treatment of the dams with As (10 or 100 mg/L
NaAsO2 in drinking water). At postnatal day 21, body weight was decreased
significantly, whereas the glutamate content in the striatum of offspring
in the 100-mg/L As group were not significantly different from those in
the control group. Although mGluR3 expression was not significantly
different, VGLUT2 and mGluR2 expression was significantly lower in the
striatum of offspring of As-exposed dams. These data indicate that altered
glutamatergic neurotransmission may contribute to As-induced developmental
neurotoxic effects.
KW - Arsenic
KW - Glutamate
KW - Striatum
KW - VGLUT2
KW - mGluR2
KW - mGluR3
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180511
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180510
STAT- Publisher
DOCNO- medline/29748927

305 - TOXLINE
TI - Mobilization of arsenic on nano-TiO2 in soil columns with sulfate reducing
bacteria.
AU - Luo T
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; School of Environmental Science and Engineering, Yancheng Institute of
Technology, Jiangsu 224051, China.
AU - Ye L
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; University of Chinese Academy of Sciences, Beijing 100049, China.
AU - Chan T
AD - National Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchy
Science Park, Hsinchu 30076, Taiwan. Electronic address: chan.ts@nsrrc.org.tw.
AU - Jing C
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic
address: cyjing@rcees.ac.cn.
SO - Environ Pollut. 2018, Mar; 234:762-768. [Environmental pollution (Barking,
Essex : 1987)]
AB - Arsenic (As) remediation in contaminated water using nanoparticles is
promising. However, the fate and transport of As associated with
nano-adsorbents in natural environment is poorly understood. To
investigate the fate of adsorbed As on nano-TiO2 in changed redox
condition from oxic to anoxic, we added the As(V)-TiO2 suspension in
groundwater to an autoclaved soil column which inoculated a
sulfate-reducing bacterium, Desulfovibrio vulgaris DP4. The dissolved
As(V) in effluent increased to 798 &mu;g/L for the biotic column and
to 1510 &mu;g/L for the abiotic control, and dissolved As(III) was
observed only in biotic column. The total As (dissolved plus particulate)
in the biotic column effluent (high to 2.5 mg/L) was substantially
higher than the abiotic control (1.5 mg/L). Therefore SRB restrained
the release of dissolved As, and facilitated the transport of particulate
As. Micro-XRF analysis suggested that the nano-TiO2 with As was mainly
retained in the influent front and that its transport was negligible. Our
pe-pH calculation and XANES analysis demonstrated that generated secondary
iron minerals containing magnetite and mackinawite mainly were responsible
for dissolved As retention, and then transported with As as particulate
As. The results shed light on the mobilization of adsorbed As on a
nano-adsorbent in an anoxic environment.
KW - Arsenic mobilization
KW - Nano-TiO(2)
KW - Soil column
KW - Sulfate reducing bacteria
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180210
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171221
STAT- In-Process
DOCNO- medline/29245150

306 - TOXLINE
TI - Chronic arsenicosis and cadmium exposure in wild snowshoe hares (Lepus
americanus) breeding near Yellowknife, Northwest Territories (Canada),
part 2: Manifestation of bone abnormalities and osteoporosis.
AU - Amuno S
AD - School of Environment and Sustainability, University of Saskatchewan,
Saskatoon, Canada. Electronic address: soa882@mail.usask.ca.
AU - Al Kaissi A
AD - Ludwig Boltzmann Institute of Osteology-Hanusch Hospital, First Medical
Department and Orthopedic Hospital of Speising, Vienna, Austria.
AU - Jamwal A
AD - Department of Biology, University of Saskatchewan, Saskatoon, Canada.
AU - Niyogi S
AD - Department of Biology, University of Saskatchewan, Saskatoon, Canada;
Toxicology Centre, University of Saskatchewan, Saskatoon, Canada.
AU - Quenneville CE
AD - Department of Mechanical Engineering, McMaster University, Ontario, Canada;
School of Biomedical Engineering, McMaster University, Ontario, Canada.
SO - Sci Total Environ. 2018, Jan 15; 612:1559-1567. [The Science of the total
environment]
AB - Various bone abnormalities, including osteoporosis, have been associated
with chronic arsenic and cadmium exposure in experimental animal models,
but information regarding the bone pathology of wild population of small
mammals breeding in contaminated environment is limited. This present
study was conducted to comparatively assess the prevalence and pattern of
skeletal abnormalities in free ranging snowshoe hares inhabiting an area
heavily contaminated by arsenic and other trace metals, near the vicinity
of the abandoned Giant mine, and in a reference location approximately
20km from the city of Yellowknife, Northwest Territories, Canada. The
femur and vertebrae of snowshoe hares from the mine area and reference
location were subjected to bone densitometry examination and biomechanical
testing using dual energy X-ray absorptiometry (DXA) and 3-point bending
test. t-test results indicated that femoral densitometry parameters such
as bone mineral density (BMD) (p=0.5), bone mineral content (BMC)
(p=0.675), bone area (BA) (p=0.978) and tissue area (TA) (p=0.549) were
not significantly different between locations. All densitometry parameters
of the vertebrae (BMD, BA and TA) differed between locations (p < 0.05),
except for BMC (p=0.951) which showed no significant difference between
the two locations. Vertebrae from the mine area also showed relatively
lower BA and TA compared to the reference location. A constellation of
skeletal abnormalities were also observed along the axial and appendicular
bones respectively. Specifically, growth defects, osteoporosis, cortical
fractures, sclerosis, and cyst like changes were commonly observed in the
femurs and vertebrae of hares from both locations. With respect to
biomechanical properties, only bone stiffness and peak load tended to be
relatively reduced in specimens from the mine area, whereas work to
failure was notably increased in specimens from the reference site
compared to those from the mine area. Taken together, the results of this
preliminary study suggest that chronic concomitant exposure to arsenic and
cadmium may be involved in the etiology of various bone abnormalities,
including osteoporosis in wild population of snowshoe hares from the
Yellowknife area. The result presented in this study represent the first
evaluation of osteological effects in free-ranging furbearers (snowshoe
hares) diagnosed with arsenicosis, and concomitantly exposed to
environmental levels of cadmium.
KW - Arsenic contamination
KW - Chronic arsenicosis
KW - Osteoporosis
KW - Snowshoe hares
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180103
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20170925
STAT- In-Process
DOCNO- medline/28922726

307 - TOXLINE
TI - Biomonitoring of Metals, Polybrominated Diphenyl Ethers, Polychlorinated
Biphenyls, and Persistent Pesticides in Vietnamese Female Electronic Waste
Recyclers.
AU - Schecter A
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
AU - Kincaid J
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
AU - Quynh HT
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
AU - Lanceta J
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
AU - Tran HTT
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
AU - Crandall R
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
AU - Shropshire W
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
AU - Birnbaum LS
AD - University of Louisville School of Medicine, Department of Pharmacology and
Toxicology, and School of Public Health and Information Sciences, Louisville,
Kentucky (Dr Schecter, Mr Crandall); Keck School of Medicine at the University of
Southern California, Los Angeles, California (Dr Kincaid); Centre for Ecologically
Sustainable Agriculture, Hanoi, Vietnam (Dr Quynh); University of Louisville School
of Medicine, Department of Internal Medicine, Louisville, Kentucky (Dr Lanceta);
Hanoi School of Public Health, Hanoi, Vietnam (Dr Tran); University of Texas School
of Public Health, Houston, Texas (Mr Shropshire); and National Cancer Institute,
National Institutes of Health, Research Triangle Park, North Carolina (Dr
Birnbaum).
SO - J Occup Environ Med. 2018, Feb; 60(2):191-197. [Journal of occupational
and environmental medicine]
AB - OBJECTIVE: Electronic waste is increasing. It is frequently recycled in
developing countries. This is the first study to report metals,
polybrominated diphenyl-ethers (PBDEs), polychlorinated biphenyls (PCBs),
2,2-bis(4-chlorophenyl)-1,1,1-trichloroethane (p,p'-DDT), and p,p'-DDE
concentrations in female e-waste workers.
AB - METHODS: Female Vietnamese recyclers and non-recyclers were studied.
Metals and halogenated organics were measured in blood and urine, and
compared with levels in women in the US National Health and Nutrition
Examination Survey (NHANES).
AB - RESULTS: Recyclers had higher serum PBDE than nonrecyclers. PCB-138/158
and PCB-153 were higher in 18 to less than 38-year-old nonrecyclers.
Median urinary arsenic in both cohorts was six to seven-fold higher than
NHANES. Median lead in blood and urine was 40% to 60% higher in recyclers
than nonrecyclers. Lead in nonrecyclers was four to six-fold higher than
NHANES. Both cohorts had higher arsenic and mercury than NHANES.
AB - CONCLUSION: Occupational exposure to PBDEs and lead occurred in recyclers.
Environmental exposure to arsenic, lead, and mercury occurred in both
cohorts. Occupational and environmental remediation are recommended.
LA - eng
IS - 1536-5948 (Electronic)
PT - Journal Article
TA - J Occup Environ Med
YR - 2018
DATE- 20180208
CITO- NLM
CS - United States
FJT - Journal of occupational and environmental medicine
STAT- In-Data-Review
DOCNO- medline/29099469

308 - TOXLINE
TI - Bioactive profiling and therapeutic potential of mushroom (Pleurotus
tuberregium) extract on Wistar albino rats (Ratus norvegicus) exposed to
arsenic and chromium toxicity.
AU - Ogbomida ET
AD - Ecotoxicology and Environmental Forensic Unit, National Centre for Energy and
Environment, (Energy Commission of Nigeria), University of Benin, Benin City,
Nigeria.
AU - Omofonmwan K
AD - Department of Environmental Studies and Resource Management, School of
Science and Technology, National Open University of Nigeria, Benin Study Centre,
Benin City, Edo State, Nigeria.
AU - Aganmwonyi I
AD - Ecotoxicology and Environmental Forensic Unit, National Centre for Energy and
Environment, (Energy Commission of Nigeria), University of Benin, Benin City,
Nigeria.
AU - Fasipe IP
AD - Ecotoxicology and Environmental Forensic Unit, National Centre for Energy and
Environment, (Energy Commission of Nigeria), University of Benin, Benin City,
Nigeria.
AU - Enuneku A
AD - Department of Environmental Management and Toxicology, Faculty of Life
Sciences, University of Benin, P.M.B 1154, Benin City, Nigeria.
AU - Ezemonye LIN
AD - Department of Animal and Environmental Biology, Faculty of Life Sciences,
University of Benin, Benin City, Nigeria.
SO - Toxicol Rep. 2018; 5:401-410. [Toxicology reports]
AB - Mushroom species are valued in gourmet traditions around the world for
their unique taste, aroma, nutritional value and medicinal potentials. The
bioactive profiling of P. tuberregium mushroom was evaluated to determine
it therapeutic effect on Wistar albino rats exposed to arsenic (As) and
chromium (Cr) toxicity. Proximate analysis of P. tuberregium showed high
composition of carbohydrate (80.24) followed by moisture (21.16), protein
(11.46), ash (3.03) and fibre (0.25) content. Phytochemical analysis
revealed the presence of polyphenols (2.58), alkaloid (2.46), oxalate
(4.25), flavonoid (1.68), tannin (0.38) and Saponin (trace) in trace
amount. Mineral analysis yielded variable amounts of Na, Mg, K and Ca.
Therapeutics assessment of P. tuberregium to Wistar albino rats exposed to
As-Cr toxicity showed improved feed and water intake during the exposure
duration. Haematological indices revealed significant increase in platelet
(PLT), granulocytes and monocytes while lymphocyte (LY) and red cell
distribution width (RDW) were low. Biochemical and redox marker of liver
and kidney profiles showed decrease in alkaline phosphatase (ALP), alanine
transaminase (ALT) and aspartate transaminase (AST) in the liver.
Creatinine and urea in the kidney also decrease while total protein
increased significantly. Malondialdehyde (MDA), reduced glutathione (GSH),
superoxide dismutase (SOD), glutathione S-transferase (GST) decrease in
the liver and kidney of the therapeutic group when compared with As-Cr
treated rats. The presence of alkaloids and flavonoids in significant
amount may have contributed in the therapeutic changes observed in all the
parameters. Therefore, our findings conclude that P. tuberregium possessed
remarkable effect against As-Cr induced toxicity in albino rats and may be
useful in metal toxicity treatment in man and may be concluded that they
are therapeutically effective.
KW - Arsenic
KW - Chromium
KW - Haematological and redox markers
KW - Pleurotus tuberregium
LA - eng
IS - 2214-7500 (Electronic)
PT - Journal Article
TA - Toxicol Rep
YR - 2018
DATE- 20180603
CITO- NLM
CS - Ireland
FJT - Toxicology reports
EDAT- 20180315
STAT- PubMed-not-MEDLINE
CM - Cites: Am J Epidemiol. 1994 Mar 1;139(5):484-92 (medline /8154472)
CM - Cites: Asian Pac J Trop Biomed. 2013 May;3(5):337-52 (medline /23646296)
CM - Cites: Toxicology. 2008 Mar 20;245(3):194-205 (medline /18291570)
CM - Cites: J Appl Toxicol. 2006 May-Jun;26(3):213-22 (medline /16389662)
CM - Cites: J Environ Biol. 2007 Apr;28(2 Suppl):333-47 (medline /17929749)
CM - Cites: J Environ Pathol Toxicol Oncol. 2001;20(2):77-88 (medline
/11394715)
CM - Cites: Sci Total Environ. 2009 Sep 1;407(18):5031-8 (medline /19555994)
CM - Cites: Biol Trace Elem Res. 2008 May;122(2):137-47 (medline /18183357)
CM - Cites: Hum Exp Toxicol. 2003 Apr;22(4):183-92 (medline /12755469)
CM - Cites: Nutrients. 2014 Jan 21;6(1):391-415 (medline /24451310)
CM - Cites: Environ Sci Pollut Res Int. 2017 Apr;24(12 ):11528-11535 (medline
/28321698)
CM - Cites: Toxicol Pathol. 2012 Oct;40(7):971-94 (medline /22723046)
CM - Cites: Environ Toxicol Pharmacol. 2005 Nov;20(3):456-64 (medline
/21783626)
CM - Cites: Indian J Pharmacol. 2013 Sep-Oct;45(5):490-5 (medline /24130385)
CM - Cites: J Appl Toxicol. 2011 Mar;31(2):95-107 (medline /21321970)
CM - Cites: J Physiol Biochem. 2013 Jun;69(2):313-23 (medline /23104078)
CM - Cites: PLoS One. 2014 Nov 04;9(11):e111101 (medline /25369061)
CM - Cites: Environ Health Perspect. 2012 Oct;120(10):1450-5 (medline
/22766030)
CM - Cites: Rev Environ Health. 2009 Apr-Jun;24(2):129-45 (medline /19658319)
CM - Cites: J Nutr. 2002 Jun;132(6):1207-13 (medline /12042435)
CM - Cites: J Ethnopharmacol. 2007 May 30;112(1):138-44 (medline /17367969)
CM - Cites: J Agric Food Chem. 2006 Mar 22;54(6):2103-10 (medline /16536582)
CM - Cites: Front Pharmacol. 2016 Dec 15;7:480 (medline /28018218)
CM - Cites: Indian J Biochem Biophys. 1984 Apr;21(2):130-2 (medline /6490072)
CM - Cites: J Ethnopharmacol. 2010 Mar 2;128(1):236-40 (medline /20079821)
CM - Cites: Phytother Res. 2005 Jan;19(1):23-8 (medline /15799004)
CM - Cites: Int J Environ Res Public Health. 2005 Dec;2(3-4):456-62 (medline
/16819101)
CM - Cites: Toxicol Appl Pharmacol. 2002 Mar 1;179(2):83-8 (medline /11884240)
CM - Cites: Toxicol Appl Pharmacol. 1984 May;73(3):492-9 (medline /6719464)
CM - Cites: Environ Health Perspect. 2003 Jul;111(9):1194-201 (medline
/12842773)
CM - Cites: Int J Environ Res Public Health. 2010 Jul;7(7):2745-88 (medline
/20717537)
CM - Cites: Arch Biochem Biophys. 1959 May;82(1):70-7 (medline /13650640)
CM - Cites: Perm J. 2015 Winter;19(1):58-61 (medline /25663207)
CM - Cites: J Biol Chem. 1972 May 25;247(10):3170-5 (medline /4623845)
CM - Cites: J Nutr. 2000 Sep;130(9):2151-6 (medline /10958806)
CM - Cites: J Toxicol Environ Health A. 2002 May 24;65(10):701-46 (medline
/12028825)
CM - Cites: Biochem Biophys Res Commun. 2000 Sep 7;275(3):810-6 (medline
/10973803)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 2012;100(Pt C):11-465 (medline
/23189751)
CM - Cites: Anal Biochem. 1979 Jun;95(2):351-8 (medline /36810)
CM - Cites: Interdiscip Toxicol. 2014 Jun;7(2):60-72 (medline /26109881)
CM - Cites: Curr Drug Discov Technol. 2015;12(1):59-63 (medline /26033234)
CM - Cites: Cell Biol Int. 2007 Jan;31(1):44-56 (medline /17055307)
CM - Cites: Life Sci. 2002 Jan 11;70(8):877-85 (medline /11853225)
CM - Cites: Arch Environ Contam Toxicol. 2003 Apr;44(3):417-20 (medline
/12712304)
CM - Cites: Evid Based Complement Alternat Med. 2013;2013:604535 (medline
/24369479)
CM - Cites: Arch Toxicol. 2004 Jul;78(7):363-8 (medline /15205887)
CM - Cites: Methods Enzymol. 1984;105:114-21 (medline /6727659)
CM - Cites: Dig Dis Sci. 2008 Mar;53(3):799-802 (medline /17717745)
CM -Cites: Neurochem Int. 2007 Mar;50(4):671-80 (medline /17291629)
CM -Cites: Indian J Exp Biol. 2005 Sep;43(9):773-81 (medline /16187527)
CM -Cites: Biochim Biophys Acta. 1979 Jan 4;582(1):67-78 (medline /760819)
CM -Cites: Chem Biol Interact. 2006 Feb 25;159(3):213-22 (medline /16387290)
CM -Cites: Neurotoxicology. 2003 Aug;24(4-5):747-53 (medline /12900089)
CM -Cites: Mediators Inflamm. 2005 Jun 9;2005(2):63-80 (medline /16030389)
CM -Cites: Pharmacology. 2001 May;62(4):224-8 (medline /11359999)
CM -Cites: Environ Health Perspect. 2009 Oct;117(10):1535-40 (medline
/20019903)
CM - Cites: Asian J Androl. 2005 Dec;7(4):399-404 (medline /16281088)
DOCNO- medline/29854610

309 - TOXLINE
TI - LncRNA UCA1 attenuates autophagy-dependent cell death through blocking
autophagic flux under arsenic stress.
AU - Gao M
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; University of Chinese Academy of Sciences, Beijing 100049, China.
AU - Li C
AD - Liver Research Center, Beijing Friendship Hospital, Capital Medical
University, Beijing 100050, China.
AU - Xu M
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; University of Chinese Academy of Sciences, Beijing 100049, China.
AU - Liu Y
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical
Science, Chinese Academy of Sciences and Anhui Province, Hefei, Anhui 230031,
China.
AU - Liu S
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic
address: sjliu@rcees.ac.cn.
SO - Toxicol Lett. 2018, Mar 01; 284:195-204. [Toxicology letters]
AB - Arsenic (As) is a naturally toxin which exists ubiquitously in foods and
various environment media, incurring diverse toxicities and health
problems. Previous studies have shown that oxidative stress, genotoxic
damage and pro-apoptotic pathways are ascribed to As-associated
detrimental effects. Meanwhile, epigenetic regulations (such as miRNAs and
histone modifications) were also reported to contribute to As-induced
adverse effects. Nonetheless, whether long non-coding RNAs (LncRNAs) are
indispensable for the regulation of As-induced biological outcomes are
nearly unknown. In this study, we identified that a lncRNA UCA1 was
markedly induced by As treatment in human hepatocytes. Functional
assessments revealed that UCA1 played a critical role in protecting
hepatocytes from As-induced autophagy inhibition. Furthermore, through
RNA-seq assay, oxidative stress induced growth inhibitor 1 (OSGIN1) was
uncovered to be the most responsive target downstream of UCA1, and miR-184
acted as an intermediate for the regulation of UCA1 on the level of OSGIN1
through a competing endogenous RNAs (ceRNAs) mechanism. Further
mechanistic investigations demonstrated that UCA1/OSGIN1 signaling
contributed to As-induced autophagic flux blockage through activating
mTOR/p70S6&#8239;K cascade, resulting in compromised cell death.
Collectively, our study deciphered a lncRNA-dictated molecular mechanism
responsible for As toxicity: UCA1 leads a protective role against
As-induced cell death through blocking autophagic flux.
KW - Arsenic toxicity
KW - Autophagy
KW - LncRNA
KW - OSGIN1
KW - UCA1
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20180207
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Toxicology letters
EDAT- 20171215
STAT- In-Process
DOCNO- medline/29248574

310 - TOXLINE
TI - Mass spectrometry based analytical approaches and pitfalls for
toxicometabolomics of arsenic in mammals: A tutorial review.
AU - Garc�a-Barrera T
AD - Department of Chemistry, Faculty of Experimental Sciences, University of
Huelva, Campus de El Carmen, 21007, Huelva, Spain; Campus of International
Excellence ceiA3, University of Huelva, Campus de El Carmen, 21007, Huelva, Spain;
Research Center of Health and Environment (CYSMA), University of Huelva, Campus de
El Carmen, 21007, Huelva, Spain. Electronic address: tamara@dqcm.uhu.es.
AU - Rodr�guez-Moro G
AD - Department of Chemistry, Faculty of Experimental Sciences, University of
Huelva, Campus de El Carmen, 21007, Huelva, Spain; Campus of International
Excellence ceiA3, University of Huelva, Campus de El Carmen, 21007, Huelva, Spain;
Research Center of Health and Environment (CYSMA), University of Huelva, Campus de
El Carmen, 21007, Huelva, Spain.
AU - Callej�n-Leblic B
AD - Department of Chemistry, Faculty of Experimental Sciences, University of
Huelva, Campus de El Carmen, 21007, Huelva, Spain; Campus of International
Excellence ceiA3, University of Huelva, Campus de El Carmen, 21007, Huelva, Spain;
Research Center of Health and Environment (CYSMA), University of Huelva, Campus de
El Carmen, 21007, Huelva, Spain.
AU - Arias-Borrego A
AD - Department of Chemistry, Faculty of Experimental Sciences, University of
Huelva, Campus de El Carmen, 21007, Huelva, Spain; Campus of International
Excellence ceiA3, University of Huelva, Campus de El Carmen, 21007, Huelva, Spain;
Research Center of Health and Environment (CYSMA), University of Huelva, Campus de
El Carmen, 21007, Huelva, Spain.
AU - G�mez-Ariza JL
AD - Department of Chemistry, Faculty of Experimental Sciences, University of
Huelva, Campus de El Carmen, 21007, Huelva, Spain; Campus of International
Excellence ceiA3, University of Huelva, Campus de El Carmen, 21007, Huelva, Spain;
Research Center of Health and Environment (CYSMA), University of Huelva, Campus de
El Carmen, 21007, Huelva, Spain.
SO - Anal Chim Acta. 2018, Feb 13; 1000:41-66. [Analytica chimica acta]
AB - The present review focus on the analytical platforms and the workflow for
toxicometabolomics with a special emphasis on their strengths and pitfalls
presenting as a case study the toxicometabolomics of arsenic in mammals.
Although powerful analytical methods and techniques are currently
available for metabolomics, the main "bottleneck" is still the absence of
unified protocols for sample preparation (e.g. quenching, solvents used)
as well as several important factors in toxicometabolomics, which
drastically affect the metabolism (e.g. selection of model organisms,
xenobiotic doses, chemical form of the xenobiotic, exposure route,
biological sample). In this context, the applicability to complex samples,
higher sensitivity, specificity and the possibility to perform
quantitative analysis offered by MS is crucial to probe xenobiotic induced
metabolic changes to evaluate the stress responses. Nowadays, the use of
different metabolomic platforms allowed determining important changes in
the metabolism induced by arsenic in mammals such as alterations in the
energy (e.g. Glycolysis, Kreb's cycle), amino acid, lipid, nucleotide and
androgen metabolisms.
KW - Arsenic
KW - Mass spectrometry
KW - Metabolomics
KW - Toxicometabolomics
LA - eng
IS - 1873-4324 (Electronic)
PT - Journal Article
PT - Review
TA - Anal Chim Acta
YR - 2018
DATE- 20171231
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Analytica chimica acta
EDAT- 20171102
STAT- In-Process
DOCNO- medline/29289324

311 - TOXLINE
TI - Toxic metal levels in cocoa powder and chocolate by ICP-MS method after
microwave-assisted digestion.
AU - Lo Dico GM
AD - Istituto Zooprofilattico Sperimentale Della Sicilia "A. Mirri", Via Gino
Marinuzzi 3, 90129 Palermo, Italy. Electronic address: gigilodico@gmail.com.
AU - Galvano F
AD - Department of Biological Chemistry, Universit� Degli Studi di Catania, Citt�
Universitaria - Via Santa Sofia, 64, Catania, Italy.
AU - Dugo G
AD - Department of Organic and Biological Chemistry and Department of Animal
Biology and Marine Ecology, Universit� Degli Studi di Messina, Vill. S. Agata,
98166 Messina, Italy.
AU - D'ascenzi C
AD - Department of Veterinary Science, Universit� Degli Studi di Pisa, viale delle
Piagge, Pisa, Italy.
AU - Macaluso A
AD - Istituto Zooprofilattico Sperimentale Della Sicilia "A. Mirri", Via Gino
Marinuzzi 3, 90129 Palermo, Italy.
AU - Vella A
AD - Istituto Zooprofilattico Sperimentale Della Sicilia "A. Mirri", Via Gino
Marinuzzi 3, 90129 Palermo, Italy.
AU - Giangrosso G
AD - Istituto Zooprofilattico Sperimentale Della Sicilia "A. Mirri", Via Gino
Marinuzzi 3, 90129 Palermo, Italy.
AU - Cammilleri G
AD - Istituto Zooprofilattico Sperimentale Della Sicilia "A. Mirri", Via Gino
Marinuzzi 3, 90129 Palermo, Italy.
AU - Ferrantelli V
AD - Istituto Zooprofilattico Sperimentale Della Sicilia "A. Mirri", Via Gino
Marinuzzi 3, 90129 Palermo, Italy.
SO - Food Chem. 2018, Apr 15; 245:1163-1168. [Food chemistry]
AB - The Commission Regulation (EC) Regulation N. 488/2014, established the
concentration limits for cadmium in specific products based on cocoa and
chocolate products as from January 2019. Based on this information there
is a need to determine ultratrace levels of elements that might be
presents in cocoa and chocolate products. In this work, the concentrations
of Arsenic, Antimony, Cadmium, Chromium, Lead, Selenium and Vanadium were
evaluated in cocoa powder and chocolate by the validation of an ICP-MS
method. Good selectivity/specificity, recovery, repeatability and
within-laboratory reproducibility, LOD, LOQ, range of linearity, standard
measurement uncertainty parameters for method validation were achieved, in
accordance with Commission Regulation. The cocoa powder revealed the
maximum metal concentrations of
0.303&#8239;&plusmn;&#8239;0.035&#8239;mg/kg for cadmium,
1.228&#8239;&plusmn;&#8239;0.146&#8239;mg/kg for lead and
0.094&#8239;&plusmn;&#8239;0.013&#8239;mg/kg for arsenic. A significant
difference was found between cocoa powder and chocolate samples
(p&#8239; < &#8239;.05).
KW - Antimony (PubChem CID: 5354495)
KW - Arsenic (PubChem CID: 5359596)
KW - Cadmium (PubChem CID: 23973)
KW - Chocolate
KW - Chromium (PubChem CID: 23976)
KW - Cocoa
KW - ICP-MS
KW - Lead (PubChem CID: 5352425)
KW - Selenium (PubChem CID: 6326970)
KW - Toxic metals
KW - Vanadium (PubChem CID: 23990).
LA - eng
IS - 0308-8146 (Print)
PT - Journal Article
TA - Food Chem
YR - 2018
DATE- 20171230
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food chemistry
EDAT- 20171115
STAT- In-Process
DOCNO- medline/29287336

312 - TOXLINE
TI - Potential health risk assessment through ingestion and dermal contact
arsenic-contaminated groundwater in Jianghan Plain, China.
AU - Li R
AD - School of Environmental Studies, China University of Geosciences, Wuhan,
430074, China.
AU - Kuo YM
AD - School of Environmental Studies, China University of Geosciences, Wuhan,
430074, China. airkuo@ntu.edu.tw.
AU - Liu WW
AD - School of Environmental Studies, China University of Geosciences, Wuhan,
430074, China.
AU - Jang CS
AD - Department of Leisure and Recreation Management, Kainan University, Luzhu,
338, Taoyuan, Taiwan, ROC.
AU - Zhao E
AD - School of Environmental Studies, China University of Geosciences, Wuhan,
430074, China.
AU - Yao L
AD - School of Environmental Studies, China University of Geosciences, Wuhan,
430074, China.
SO - Environ Geochem Health. 2018, Feb 01. [Environmental geochemistry and
health]
AB - Groundwater contamination with high arsenic (As) levels has caused serious
health problem in Jianghan Plain. This study presents a framework to
evaluate the results and their probable influencing factors of
non-carcinogenic risk and carcinogenic risk in Shahu Village. An
appropriate health risk assessment for residents exposing to As through
ingestion and dermal contact pathways is also discussed in the paper.
Hazard quotient (HQ) and target cancer risk (TR) are adopted to compute
the non-carcinogenic and carcinogenic effects for residents, respectively.
Monte Carlo simulation technique is used to quantify the uncertainty of
the risk assessment. The assessment results show that the HQs and TRs of
10-m-deep and 25-m-deep wells exhibit seasonal variations with higher
values in rainy season and lower values in dry season. The HQ values
exceeding 1 at the depths of 10 (from 0.09 to 23.21 m) and 25 m
(from 0.29 to 130.55 m) account for 61 and 94%, respectively, which
associate with the As contents distribution in the aquifer sediments. The
estimated TR values at the depths of 10 (from 3.86E-05 to 1.04E-02) and
25 m (from 1.32E-04 to 5.87E-02) exceeding the highest acceptable
standard (10-4) account for 95 and 100%, respectively. Comparison of the
two exposure pathways, the ingestion exposure contributes much more than
the dermal contact exposure for both non-carcinogenic risk and
carcinogenic risk. The results of sensitivity analysis indicate that a
more accurate measurement and better definition of probability
distributions for As concentration in the groundwater can increase the
accuracy of health risk assessment in Jianghan Plain. The findings
demonstrate the importance of the drinking water safety, and the
government should take measures to ensure the drinking water safety.
KW - Arsenic
KW - Hazard quotient
KW - Health risk
KW - Monte Carlo simulation
KW - Target cancer risk
KW - Uncertainty
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180202
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20180201
STAT- Publisher
DOCNO- medline/29392546

313 - TOXLINE
TI - Relating soil geochemical properties to arsenic bioaccessibility through
hierarchical modeling.
AU - Nelson CM
AD - a National Exposure Research Laboratory, Office of Research and Development ,
U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.
AU - Li K
AD - b Department of Civil, Construction, and Environmental Engineering , North
Carolina State University , Raleigh , NC , USA.
AU - Obenour DR
AD - b Department of Civil, Construction, and Environmental Engineering , North
Carolina State University , Raleigh , NC , USA.
AU - Miller J
AD - b Department of Civil, Construction, and Environmental Engineering , North
Carolina State University , Raleigh , NC , USA.
AU - Misenheimer JC
AD - c Oak Ridge Institute for Science and Education Research Participant ,
Research Triangle Park , NC , USA.
AU - Scheckel K
AD - d Office of Research and Development , U.S. Environmental Protection Agency ,
Cincinnati , OH , USA.
AU - Betts A
AD - e Department of Plant and Soil Sciences , University of Delaware , Newark ,
DE , USA.
AU - Juhasz A
AD - f Centre for Environmental Risk Assessment and Remediation , University of
South Australia , Mawson Lakes , SA Australia.
AU - Thomas DJ
AD - g National Health and Environmental Effects Research Laboratory, Office of
Research and Development , U.S. Environmental Protection Agency , Research Triangle
Park , NC , USA.
AU - Bradham KD
AD - a National Exposure Research Laboratory, Office of Research and Development ,
U.S. Environmental Protection Agency , Research Triangle Park , NC , USA.
SO - J Toxicol Environ Health A. 2018; 81(6):160-172. [Journal of toxicology
and environmental health. Part A]
AB - Interest in improved understanding of relationships among soil properties
and arsenic (As) bioaccessibility has motivated the use of regression
models for As bioaccessibility prediction. However, limits in the numbers
and types of soils included in previous studies restrict the usefulness of
these models beyond the range of soil conditions evaluated, as evidenced
by reduced predictive performance when applied to new data. In response,
hierarchical models that consider variability in relationships among soil
properties and As bioaccessibility across geographic locations and
contaminant sources were developed to predict As bioaccessibility in 139
soils on both a mass fraction (mg/kg) and % basis. The hierarchical
approach improved the estimation of As bioaccessibility in studied soils.
In addition, the number of soil elements identified as statistically
significant explanatory variables increased when compared to previous
investigations. Specifically, total soil Fe, P, Ca, Co, and V were
significant explanatory variables in both models, while total As, Cd, Cu,
Ni, and Zn were also significant in the mass fraction model and Mg was
significant in the % model. This developed hierarchical approach provides
a novel tool to (1) explore relationships between soil properties and As
bioaccessibility across a broad range of soil types and As contaminant
sources encountered in the environment and (2) identify areas of future
mechanistic research to better understand the complexity of interactions
between soil properties and As bioaccessibility.
KW - arsenic
KW - bioaccessibility
KW - hierarchical modeling
KW - properties
KW - soil
LA - eng
IS - 1528-7394 (Print)
PT - Journal Article
TA - J Toxicol Environ Health A
YR - 2018
DATE- 20180201
CITO- NLM
CS - England
FJT - Journal of toxicology and environmental health. Part A
EDAT- 20180116
STAT- In-Data-Review
DOCNO- medline/29336680

314 - TOXLINE
TI - Brand switching and toxic chemicals in cigarette smoke: A national study.
AU - Mendel JR
AD - Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel
Hill, NC, United States of America.
AU - Baig SA
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, United States of America.
AU - Hall MG
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, United States of America.
AU - Jeong M
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, United States of America.
AU - Byron MJ
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, United States of America.
AU - Morgan JC
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, United States of America.
AU - Noar SM
AD - School of Media and Journalism, University of North Carolina, Chapel Hill,
NC, United States of America.
AU - Ribisl KM
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, United States of America.
AU - Brewer NT
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina, Chapel Hill, NC, United States of America.
SO - PLoS One. 2018; 13(1):e0189928. [PloS one]
AB - INTRODUCTION: US law requires disclosure of quantities of toxic chemicals
(constituents) in cigarette smoke by brand and sub-brand. This information
may drive smokers to switch to cigarettes with lower chemical quantities,
under the misperception that doing so can reduce health risk. We sought to
understand past brand-switching behavior and whether learning about
specific chemicals in cigarette smoke increases susceptibility to brand
switching.
AB - METHODS: Participants were US adult smokers surveyed by phone (n = 1,151,
probability sample) and online (n = 1,561, convenience sample). Surveys
assessed whether smokers had ever switched cigarette brands or styles to
reduce health risk and about likelihood of switching if the smoker learned
their brand had more of a specific chemical than other cigarettes.
Chemicals presented were nicotine, carbon monoxide, lead, formaldehyde,
arsenic, and ammonia.
AB - RESULTS: Past brand switching to reduce health risk was common among
smokers (43% in phone survey, 28% in online survey). Smokers who were
female, over 25, and current "light" cigarette users were more likely to
have switched brands to reduce health risks (all p < .05). Overall,
61-92% of smokers were susceptible to brand switching based on information
about particular chemicals. In both samples, lead, formaldehyde, arsenic,
and ammonia led to more susceptibility to switch than nicotine (all p <
.05).
AB - CONCLUSIONS: Many US smokers have switched brands or styles to reduce
health risks. The majority said they might or would definitely switch
brands if they learned their cigarettes had more of a toxic chemical than
other brands. Brand switching is a probable unintended consequence of
communications that show differences in smoke chemicals between brands.
RN - 1HG84L3525
RN - 2P299V784P
RN - 6M3C89ZY6R
RN - 7664-41-7
RN - 7U1EE4V452
RN - N712M78A8G
LA - eng
IS - 1932-6203 (Electronic)
PT - Journal Article
PT - Research Support, N.I.H., Extramural
PT - Research Support, Non-U.S. Gov't
TA - PLoS One
YR - 2018
DATE- 20180130
CITO- NLM
CS - United States
CSET- IM
FJT - PloS one
EDAT- 20180111
STAT- MEDLINE
CM - Cites: MMWR Morb Mortal Wkly Rep. 2012 Nov 9;61(44):889-94 (medline
/23134971)
CM - Cites: Tob Control. 2016 Sep;26(5):592-599 (medline /27924009)
CM - Cites: J Health Soc Behav. 1985 Sep;26(3):156-82 (medline /3905939)
CM - Cites: Nicotine Tob Res. 2002;4 Suppl 2:S147-55 (medline /12573176)
CM - Cites: Soc Sci Med. 2000 May;50(10):1385-401 (medline /10741575)
CM - Cites: Nicotine Tob Res. 2016 Jul;18(7):1566-74 (medline /26681775)
CM - Cites: Tob Control. 2002 Mar;11(1):14-9 (medline /11891362)
CM - Cites: BMC Public Health. 2016 Jun 23;16:516 (medline /27333921)
CM - Cites: J Adolesc Health. 2014 Jan;54(1):33-9 (medline /24012064)
CM - Cites: Am J Prev Med. 1998 Jul;15(1):9-16 (medline /9651633)
CM - Cites: J Health Commun. 2014 Sep;19(9):1064-75 (medline /24628465)
CM - Cites: J Behav Med. 2017 Aug;40(4):553-564 (medline /28224264)
CM - Cites: Nicotine Tob Res. 2014 Mar;16(3):343-50 (medline /24151139)
CM - Cites: Tob Control. 2015 Nov;24(6):609-15 (medline /25260750)
CM - Cites: Tob Control. 2009 Dec;18(6):485-90 (medline /19892697)
CM - Cites: Med Decis Making. 2001 Jan-Feb;21(1):37-44 (medline /11206945)
CM - Cites: Tob Control. 2007 Dec;16(6):e7 (medline /18048597)
CM - Cites: Tob Control. 2001;10 Suppl 1:i17-23 (medline /11740040)
CM - Cites: Tob Control. 2016 Sep;25(5):517-20 (medline /26628496)
CM - Cites: Am J Public Health. 1996 Jan;86(1):18-24 (medline /8561236)
CM - Cites: N Engl J Med. 1989 Jun 15;320(24):1619-21 (medline /2725602)
DOCNO- medline/29324749

315 - TOXLINE
TI - Vacuolar transporters for cadmium and arsenic in plants and their
applications in phytoremediation and crop development.
AU - Zhang J
AD - Department of Integrative Bioscience &amp; Biotechnology, Pohang University
of Science and Technology, Pohang, Korea.
AU - Martinoia E
AD - Institut f�r Pflanzenbiologie, Universit�t Z�rich, Zollikerstrasse 107, 8008
Z�rich, Switzerland.
AU - Lee Y
AD - Department of Life Science, Pohang University of Science and Technology,
Pohang, Korea.
SO - Plant Cell Physiol. 2018, Jan 18. [Plant & cell physiology]
AB - Soil contamination by heavy metals and metalloids such as cadmium (Cd) and
arsenic (As) poses a major threat to the environment and to human health.
Vacuolar sequestration is one of the main mechanisms by which plants
control toxic materials including Cd and As. Understanding the mechanisms
of heavy metal tolerance and accumulation can be useful both for
phytoremediation and safe crop development. In this review, we summarize
recent advances in deciphering the molecular mechanisms underlying
vacuolar sequestration of Cd and As, and discuss potential
biotechnological applications of this knowledge and efforts towards
attaining these goals.
KW - Arsenic
KW - cadmium
KW - phytoremediation
KW - safe crop
KW - vacuolar transporter
LA - eng
IS - 1471-9053 (Electronic)
PT - Journal Article
TA - Plant Cell Physiol
YR - 2018
DATE- 20180123
CI - &copy; The Author 2018. Published by Oxford University Press on behalf of
Japanese Society of Plant Physiologists. All rights reserved. For
Permissions, please e-mail: journals.permissions@oup.com.
CITO- NLM
CS - Japan
FJT - Plant &amp; cell physiology
EDAT- 20180118
STAT- Publisher
DOCNO- medline/29361141

316 - TOXLINE
TI - Epigallocatechin-3-gallate partially restored redox homeostasis in
arsenite-stressed keratinocytes.
AU - Sarkar N
AD - Department of Receptor Biology and Tumor Metastasis, Chittaranjan National
Cancer Institute, 37, S.P. Mukherjee Road, Kolkata, 700026, India.
AU - Sinha D
AD - Department of Receptor Biology and Tumor Metastasis, Chittaranjan National
Cancer Institute, 37, S.P. Mukherjee Road, Kolkata, 700026, India.
SO - J Appl Toxicol. 2018, Aug; 38(8):1071-1080. [Journal of applied toxicology
: JAT]
AB - Arsenite (AsIII) is known for inducing severe oxidative stress and skin
carcinogenesis. Contrastingly, phytochemical, epigallocatechin-3-gallate
(EGCG) combats toxic insults. Our study focused on the effect of EGCG on
redox status of AsIII-stressed normal human keratinocytes, HaCaT cells.
EGCG (50 &mu;m) increased the cell viability by 29% in AsIII
(50 &mu;m) insulted HaCaT cells but exhibited pro-oxidant activity by
elevated expression of the oxidative stress markers. EGCG was effective
not only in reducing AsIII-induced nuclear expression of Nrf2 and
Nrf2Ser40 but also in increasing nuclear expression of Keap1 both at
protein and mRNA level. EGCG did not have similar effects on all Nrf2
downstream targets. EGCG elevated expression of HO-1 and
&gamma;-GCL,showed no change in MRP1 but decreased superoxide dismutase,
NAD(P)H dehydrogenase quinone 1 and glutathione S transferase activity in
AsIII-treated HaCaT cells. EGCG along with AsIII caused decreased
phosphorylation of Nrf2 at ser40 residue, which might have facilitated
Keap1-mediated nuclear export and degradation of Nrf2 and paved the
pro-survival signal for AsIII-insulted HaCaT cells. In conclusion, it
might be indicated that EGCG in spite of inducing the pro-oxidant effect
was effective in increasing the viability of AsIII-treated HaCaT cells by
partially restoring the Nrf2/Keap1-mediated signaling axis.
KW - Arsenite
KW - EGCG
KW - Keap1
KW - Nrf2
KW - pro-oxidant
KW - redox homeostasis
LA - eng
IS - 1099-1263 (Electronic)
PT - Journal Article
TA - J Appl Toxicol
YR - 2018
DATE- 20180612
CI - Copyright &copy; 2018 John Wiley &amp; Sons, Ltd.
CITO- NLM
CS - England
FJT - Journal of applied toxicology : JAT
EDAT- 20180323
STAT- In-Data-Review
DOCNO- medline/29572906

317 - TOXLINE
TI - Arsenic-induced nutrient uptake in As-hyperaccumulator Pteris vittata and
their potential role to enhance plant growth.
AU - Liu X
AD - Research Center for Soil Contamination and Remediation, Southwest Forestry
University, Kunming, 650224, China.
AU - Feng HY
AD - State Key Lab of Pollution Control and Resource Reuse, School of the
Environment, Nanjing University, Jiangsu, 210023, PR China.
AU - Fu JW
AD - State Key Lab of Pollution Control and Resource Reuse, School of the
Environment, Nanjing University, Jiangsu, 210023, PR China.
AU - Chen Y
AD - State Key Lab of Pollution Control and Resource Reuse, School of the
Environment, Nanjing University, Jiangsu, 210023, PR China.
AU - Liu Y
AD - Research Center for Soil Contamination and Remediation, Southwest Forestry
University, Kunming, 650224, China. Electronic address: yungenliu@swfu.edu.cn.
AU - Ma LQ
AD - Research Center for Soil Contamination and Remediation, Southwest Forestry
University, Kunming, 650224, China; Soil and Water Science Department, University
of Florida, Gainesville, FL, 32611, United States. Electronic address:
lqma@ufl.edu.
SO - Chemosphere. 2018, May; 198:425-431. [Chemosphere]
AB - It is known that arsenic (As) promotes growth of As-hyperaccumulator
Pteris vittata (PV), however, the associated mechanisms are unclear. Here
we examined As-induced nutrient uptake in P. vittata and their
potential role to enhance plant growth in sterile agar by excluding
microbial effects. As-hyperaccumulator P. multifida (PM) and
non-hyperaccumulator P. ensiformis (PE) belonging to the Pteris genus
were used as comparisons. The results showed that, after 40&#8239;d of
growth, As induced biomass increase in hyperaccumulators PV and PM by
5.2-9.4 fold whereas it caused 63% decline in PE. The data suggested that
As played a beneficial role in promoting hyperaccumulator growth. In
addition, hyperaccumulators PV and PM accumulated 7.5-13, 1.4-3.6, and
1.8-4.4 fold more As, Fe, and P than the non-hyperaccumulator PE. In
addition, nutrient contents such as K and Zn were also increased while Ca,
Mg, and Mn decreased or unaffected under As treatment. This study
demonstrated that As promoted growth in hyperaccumulators and enhanced Fe,
P, K, and Zn uptake. Different plant growth responses to As among
hyperaccumulators PV and PM and non-hyperaccumulator PE may help to better
understand why hyperaccumulators grow better under As-stress.
KW - Phytoremediation
KW - Plant growth
KW - Pteris ensiformis
KW - Pteris multifida
KW - Pteris vittata
KW - Sterile
RN - 27YLU75U4W
RN - N712M78A8G
RN - N762921K75
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180530
CI - Published by Elsevier Ltd.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180203
STAT- MEDLINE
DOCNO- medline/29421759

318 - TOXLINE
TI - In vivo assessment of polydatin, a natural polyphenol compound, on
arsenic-induced free radical overproduction, gene expression, and
genotoxicity.
AU - Arslan-Acaroz D
AD - Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe
University, 03200, Afyonkarahisar, Turkey.
AU - Zemheri F
AD - Department of Molecular Biology and Genetics, Faculty of Art and Science,
Bartin University, 74100, Bartin, Turkey.
AU - Demirel HH
AD - Bayat Vocational School, Afyon Kocatepe University, Bayat, Afyonkarahisar,
Turkey.
AU - Kucukkurt I
AD - Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe
University, 03200, Afyonkarahisar, Turkey.
AU - Ince S
AD - Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine,
Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey. since@aku.edu.tr.
AU - Eryavuz A
AD - Department of Physiology, Faculty of Veterinary Medicine, Afyon Kocatepe
University, 03200, Afyonkarahisar, Turkey.
SO - Environ Sci Pollut Res Int. 2018, Jan; 25(3):2614-2622. [Environmental
science and pollution research international]
AB - Arsenic (As) is a well-known contaminant of global groundwater. Its
exposure causes several hazardous effects on animals and human via
oxidative stress. The present study examined the effect of polydatin (PD)
on free radical overproduction in rats exposed to As. Thirty-five male
rats randomly allocated into five equal groups. To the control group,
physiological saline was given orally and to the second group only
100 mg/L As was given by drinking water for 60 days. The other
groups were treated with As (100 mg/L) and PD orally at 50, 100, and
200 mg/kg/day, respectively. Treatment with As enhanced
malondialdehyde level but decreased glutathione level in blood, liver,
kidney, brain, lung, and heart of rats. Also, As decreased superoxide
dismutase and catalase activities of erythrocyte, liver, kidney, brain,
lung, and heart in rats. Furthermore, As treatment gave rise to increased
DNA damage and gene expressions of interleukin 1 beta (IL-1&beta;),
nuclear factor kappa beta (NF&kappa;B), p53, and tumor necrosis
factor-&alpha; (TNF-&alpha;) in the lung, brain, kidney, and liver.
However, treatment of PD ameliorated As-exposed lipid peroxidation,
antioxidant enzymes activities, DNA damage, gene expressions, and
histopathological changes in tissues. In conclusion, PD has a
dose-dependent protective effect on lipid peroxidation and antioxidant
defense mechanism in rats against As exposure.
KW - Arsenic
KW - DNA damage
KW - Gene expression
KW - Oxidative stress
KW - Polydatin
KW - Rat
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180121
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171112
STAT- In-Process
CM - Cites: Toxicology. 2003 May 1;187(1):39-48 (medline /12679051)
CM - Cites: J Lab Clin Med. 1963 May;61:882-8 (medline /13967893)
CM - Cites: Mutat Res. 2005 Aug 1;585(1-2):71-8 (medline /16005255)
CM - Cites: World J Gastroenterol. 1999 Feb;5(1):41-44 (medline /11819383)
CM - Cites: Clin Chem. 1988 Mar;34(3):497-500 (medline /3349599)
CM - Cites: Toxicol Appl Pharmacol. 1999 Aug 15;159(1):65-75 (medline
/10448126)
CM - Cites: Toxicol Appl Pharmacol. 2016 Sep 1;306:98-104 (medline /27425828)
CM - Cites: Mol Pharmacol. 1999 Jul;56(1):102-9 (medline /10385689)
CM - Cites: Food Chem Toxicol. 2014 Oct;72:147-53 (medline /25051394)
CM - Cites: Toxicol Pathol. 2004 Jan-Feb;32(1):64-72 (medline /14713550)
CM - Cites: J Biochem Mol Toxicol. 2015 Dec;29(12 ):564-71 (medline /26184899)
CM - Cites: Environ Health Perspect. 2003 May;111(6):825-35 (medline /12760830)
CM - Cites: J Nat Sci Biol Med. 2013 Jul;4(2):393-5 (medline /24082739)
CM - Cites: Toxicol Ind Health. 2016 Mar;32(3):410-21 (medline /24105067)
CM - Cites: Talanta. 2002 Aug 16;58(1):201-35 (medline /18968746)
CM - Cites: Toxicol Ind Health. 2013 Nov;29(10):904-14 (medline /22609855)
CM -Cites: Exp Toxicol Pathol. 2010 Sep;62(5):543-7 (medline /19674877)
CM -Cites: Biomolecules. 2015 Sep 24;5(4):2184-93 (medline /26404387)
CM -Cites: Drug Deliv. 2011 Aug;18(6):451-9 (medline /21554158)
CM -Cites: Methods Enzymol. 1990;186:421-31 (medline /2233309)
CM -Cites: Toxicol Mech Methods. 2009 Feb;19(2):169-82 (medline /19778263)
CM -Cites: Mol Cell Endocrinol. 2012 Oct 15;362(1-2):183-93 (medline
/22732364)
CM - Cites: J Natl Cancer Inst. 2002 Nov 20;94(22):1688-96 (medline /12441324)
CM - Cites: Anal Biochem. 1979 Jun;95(2):351-8 (medline /36810)
CM - Cites: Chemosphere. 2014 Aug;108:197-204 (medline /24530163)
CM - Cites: Carcinogenesis. 2003 Apr;24(4):747-56 (medline /12727804)
CM - Cites: Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8103-7 (medline
/9653147)
CM - Cites: Toxicol Appl Pharmacol. 2005 Apr 1;204(1):18-26 (medline /15781290)
CM - Cites: J Biol Chem. 1951 Nov;193(1):265-75 (medline /14907713)
CM - Cites: Toxicol Appl Pharmacol. 2004 May 1;196(3):396-403 (medline
/15094310)
CM - Cites: J Lab Clin Med. 1975 Feb;85(2):337-41 (medline /803541)
CM - Cites: Circ Res. 2000 Mar 17;86(5):514-9 (medline /10720412)
CM - Cites: J Biochem Mol Toxicol. 2008 Feb;22(1):15-26 (medline /18273903)
DOCNO- medline/29130132

319 - TOXLINE
TI - Effect of rhizobacteria on arsenic uptake by macrophyte Eichhornia
crassipes (Mart.) Solms.
AU - Kaur P
AD - a Department of Biotechnology , Lovely Professional University , Phagwara ,
Punjab , India.
AU - Singh S
AD - a Department of Biotechnology , Lovely Professional University , Phagwara ,
Punjab , India.
AU - Kumar V
AD - a Department of Biotechnology , Lovely Professional University , Phagwara ,
Punjab , India.
AU - Singh N
AD - b Department of Microbiology , Akal College of Basic Sciences, Eternal
University , Baru Sahib , Himachal Pradesh , India.
AU - Singh J
AD - a Department of Biotechnology , Lovely Professional University , Phagwara ,
Punjab , India.
SO - Int J Phytoremediation. 2018, Jan 28; 20(2):114-120. [International
journal of phytoremediation]
AB - Wastewater flowing in streams and nallahs across India carries several
trace metals, including metalloid arsenic (As), which are considered
serious environmental contaminants due to their toxicity, and recalcitrant
nature. In this study, we determined the phytoremediation of As by
Eichhornia crassipes (Mart.) Solms either alone or in association with
plant growth-promoting rhizobacteria. Pseudomonas and Azotobacter
inoculation to E. crassipes resulted in enhanced As removal compared to
uninoculated control. Co-inoculation with a consortium of Pseudomonas,
Azotobacter, Azospirillum, Actinomyces, and Bacillus resulted in a higher
As (p < 0.05) phytoaccumulation efficiency. P. aeruginosa strain jogii
was found particularly effective in augmenting As removal by E. crassipes.
Our findings indicate that the synergistic association of E. crassipes and
various rhizobacteria is an effective strategy to enhance removal of As
and thus may be utilized as an efficient biological alternative for the
removal of this metalloid from wastewaters.
KW - Arsenic
KW - Eichhornia crassipes
KW - macrophyte
KW - phytoremediation
KW - rhizobacteria
LA - eng
IS - 1549-7879 (Electronic)
PT - Journal Article
TA - Int J Phytoremediation
YR - 2018
DATE- 20180119
CITO- NLM
CS - United States
FJT - International journal of phytoremediation
STAT- In-Process
DOCNO- medline/28613914

320 - TOXLINE
TI - Rhizophagus irregularis influences As and P uptake by alfafa and the
neighboring non-host pepperweed growing in an As-contaminated soil.
AU - Zhang X
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Electronic address: xinzhang@rcees.ac.cn.
AU - Ren B
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
AU - Wu S
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
AU - Sun Y
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
AU - Chen B
AD - State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
AU - Li R
AD - Yunnan Forestry Technological College, Kunming 650224, China.
SO - J Environ Sci (China). 2018, May; 67:36-44. [Journal of environmental
sciences (China)]
AB - It was documented that arbuscular mycorrhiza fungi (AMF) play an important
role in protecting host plants against arsenic (As) contamination.
However, most terrestrial ecosystems contain a considerable number of
nonmycorrhizal plants. So far little information is available for the
interaction of such non-host plants with AMF under As contaminations. By
using a dual compartment cultivation system with a plastic board or a
nylon mesh separating roots of non-host pepperweed from roots of the
AM-host alfafa plants, avoiding direct root competition, the two plant
species were grown separately or partially separated (with rhizosphere
effects) in the presence or absence of the AMF Rhizophagus irregularis in
As-contaminated soil. The results indicated that mycorrhiza caused
phosphorus (P) concentration decrease in the non-host pepperweed, but
promoted the P concentration of the AM host alfafa. Mycorrhiza is
potentially helpful for non-host pepperweed to adapt to As contamination
by decreasing root As concentration and showing no suppressing effect on
biomass production. The study provides further evidence for the protective
effects of AMF on non-host plants against As contamination, and improved
our understanding of the potential role of AMF for non-host plant
adaptation to As contaminated soils.
KW - AM fungi
KW - Arsenic contamination
KW - Interaction
KW - Non-host plant
RN - 27YLU75U4W
RN - N712M78A8G
LA - eng
IS - 1001-0742 (Print)
PT - Journal Article
TA - J Environ Sci (China)
YR - 2018
DATE- 20180601
CI - Copyright &copy; 2017. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Journal of environmental sciences (China)
EDAT- 20170715
STAT- MEDLINE
DOCNO- medline/29778169

321 - TOXLINE
TI - Arsenic methylation by a novel ArsM As(III) S-adenosylmethionine
methyltransferase that requires only two conserved cysteine residues.
AU - Huang K
AD - Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization,
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource
Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural
University, Nanjing, 210095, China.
AU - Xu Y
AD - Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization,
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource
Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural
University, Nanjing, 210095, China.
AU - Packianathan C
AD - Department of Cellular Biology and Pharmacology, Herbert Wertheim College of
Medicine, Florida International University, Miami, FL, USA.
AU - Gao F
AD - Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization,
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource
Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural
University, Nanjing, 210095, China.
AU - Chen C
AD - Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization,
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource
Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural
University, Nanjing, 210095, China.
AU - Zhang J
AD - Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization,
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource
Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural
University, Nanjing, 210095, China.
AU - Shen Q
AD - Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization,
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource
Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural
University, Nanjing, 210095, China.
AU - Rosen BP
AD - Department of Cellular Biology and Pharmacology, Herbert Wertheim College of
Medicine, Florida International University, Miami, FL, USA.
AU - Zhao FJ
AD - Jiangsu Provincial Key Laboratory for Organic Solid Waste Utilization,
Jiangsu Collaborative Innovation Center for Solid Organic Waste Resource
Utilization, College of Resources and Environmental Sciences, Nanjing Agricultural
University, Nanjing, 210095, China.
SO - Mol Microbiol. 2018, Jan; 107(2):265-276. [Molecular microbiology]
AB - Arsenic (As) biomethylation is an important component of the As
biogeochemical cycle that can influence As toxicity and mobility in the
environment. Biomethylation of As is catalyzed by the enzyme arsenite
(As[III]) S-adenosylmethionine methyltransferase (ArsM). To date, all
identified ArsM orthologs with As(III) methylation activities have four
conserved cysteine residues, which are thought to be essential for As(III)
methylation. Here, we isolated an As(III)-methylating bacterium, Bacillus
sp. CX-1, and identified a gene encoding a S-adenosylmethionine
methyltranserase termed BlArsM with low sequence similarities
(&le; 39%) to other ArsMs. BlArsM has six cysteine residues (Cys10,
Cys11, Cys145, Cys193, Cys195 and Cys268), three of which (Cys10, Cys145
and Cys195) align with conserved cysteine residues found in most ArsMs.
BlarsM is constitutively expressed in Bacillus sp. CX-1. Heterologous
expression of BlarsM conferred As(III) resistance. Purified BlArsM
methylated both As(III) and methylarsenite (MAs[III]), with a final
product of dimethylarsenate (DMAs[V]). When all six cysteines were
individually altered to serine residues, only C145S and C195S derivatives
lost the ability to methylate As(III) and MAs(III). The derivative
C10S/C11S/C193S/C268S was still active. These results suggest that BlArsM
is a novel As(III) S-adenosylmethionine methyltransferase requiring only
two conserved cysteine residues. A model of As(III) methylation by BlArsM
is proposed.
LA - eng
IS - 1365-2958 (Electronic)
PT - Journal Article
TA - Mol Microbiol
YR - 2018
DATE- 20180110
CI - &copy; 2017 John Wiley &amp; Sons Ltd.
CITO- NLM
CS - England
FJT - Molecular microbiology
EDAT- 20171123
STAT- In-Data-Review
CM - Cites: Appl Environ Microbiol. 2015 Apr;81(8):2852-60 (medline /25681184)
CM - Cites: Nucleic Acids Res. 2009 Jan;37(Database issue):D387-92 (medline
/18931379)
CM - Cites: Chem Res Toxicol. 2004 Dec;17(12):1621-9 (medline /15606138)
CM - Cites: Proc Natl Acad Sci U S A. 2014 May 27;111(21):7701-6 (medline
/24821808)
CM - Cites: Mol Microbiol. 2017 Apr;104(2):250-259 (medline /28127843)
CM - Cites: Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):505-15
(medline /25760600)
CM - Cites: Plant Physiol. 2011 Jul;156(3):1631-8 (medline /21562336)
CM - Cites: Environ Microbiol. 2012 Dec;14(12):3097-109 (medline /23057575)
CM - Cites: Biomed J. 2016 Feb;39(1):5-13 (medline /27105594)
CM - Cites: Oral Microbiol Immunol. 1989 Mar;4(1):47-51 (medline /2628868)
CM - Cites: Toxicol Appl Pharmacol. 2000 Mar 1;163(2):203-7 (medline /10698679)
CM - Cites: Arch Toxicol. 2000 Aug;74(6):289-99 (medline /11005674)
CM - Cites: Arch Toxicol. 2005 Apr;79(4):183-91 (medline /15526190)
CM - Cites: Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5213-7 (medline
/19276121)
CM - Cites: Environ Microbiol. 2015 Jun;17(6):1897-909 (medline /25039305)
CM - Cites: Microbiol Mol Biol Rev. 2002 Jun;66(2):250-71 (medline /12040126)
CM -Cites: Trends Plant Sci. 2012 Mar;17(3):155-62 (medline /22257759)
CM -Cites: Environ Int. 2009 Apr;35(3):647-54 (medline /19110310)
CM -Cites: J Bacteriol. 1995 Feb;177(4):981-6 (medline /7860609)
CM -Cites: New Phytol. 2005 Dec;168(3):551-8 (medline /16313638)
CM -Cites: Sci Rep. 2017 Mar 07;7:42198 (medline /28266584)
CM -Cites: Biochemistry. 2012 Jul 10;51(27):5476-85 (medline /22712827)
CM -Cites: Annu Rev Earth Planet Sci. 2014 May 1;42:443-467 (medline
/26778863)
CM - Cites: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2075-80 (medline
/16452170)
CM - Cites: Plant Physiol. 2010 Apr;152(4):2211-21 (medline /20130102)
CM - Cites: Environ Sci Technol. 2014 Nov 4;48(21):12706-13 (medline /25295694)
CM - Cites: Toxicol Appl Pharmacol. 2012 Jul 15;262(2):185-93 (medline
/22575231)
CM - Cites: Environ Sci Technol. 2016 Jun 21;50(12 ):6389-96 (medline
/27258163)
CM - Cites: BMC Struct Biol. 2006 Mar 09;6:4 (medline /16526955)
CM - Cites: Appl Environ Microbiol. 2015 Oct;81(19):6718-24 (medline /26187966)
CM - Cites: Biochemistry. 2012 Feb 7;51(5):944-51 (medline /22257120)
CM - Cites: Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W363-7 (medline
/15980490)
CM - Cites: Waste Manag. 2017 Jun;64:333-339 (medline /28320622)
CM - Cites: Chem Res Toxicol. 2014 Nov 17;27(11):1979-89 (medline /25325836)
CM - Cites: Aquat Toxicol. 2014 Apr;149:50-7 (medline /24561426)
CM - Cites: Bioinformatics. 2011 Feb 1;27(3):343-50 (medline /21134891)
CM - Cites: J Biol Chem. 2002 Mar 29;277(13):10795-803 (medline /11790780)
DOCNO- medline/29134708

322 - TOXLINE
TI - The role of molecular modelling strategies in validating the effects of
chrysin on sodium arsenite-induced chromosomal and DNA damage.
AU - Babangida S
AD - 1 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
AU - Ibrahim S
AD - 1 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
AU - Muhammad A
AD - 1 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
AU - Arthur DE
AD - 2 Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.
AU - Uzairu A
AD - 2 Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria.
AU - Garba A
AD - 1 Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria.
SO - Hum Exp Toxicol. 2018, Jan 01:960327117751233. [Human & experimental
toxicology]
AB - Chrysin (CHR) is a food-based bioactive ingredient whereas, sodium
arsenite (SA) is one of the major contaminant in drinking water. When
ingested, SA contributes to tissue damage due to bioactivation by
S-adenosyl methionine (SAM)-dependent methyltransferase. Hence, the needs
to nullify this effect by investigating the potentials of CHR on
SA-induced genotoxicity in rats. The experiment was divided into two
successive stages (ameliorative and preventive, curative studies) for 1
week. Rats were divided into four groups: distilled water, 10mg/kg SA,
10mg/kg CHR and co-administration. In stage 2, the experimental groups
were given either CHR or SA for 1 week, and treated in reversed order for
additional week. Lipid peroxidation, protein carbonyl and DNA
fragmentation in liver, blood brain and bone marrow cells micronucleus
were assayed for using standard protocols. Molecular docking of
SAM-dependent methyltransferase in the presence of CHR was conducted. CHR
significantly ( p < 0.05) decreased the level of lipid peroxidation,
protein carbonyls and DNA fragmentation in blood, liver and brain tissues
as against group treated with SA. It also significantly ( p < 0.05)
reduced the level of micronuclei generated in bone marrow cells. The
effects of CHR were shown to be ameliorative, preventive and curative in
nature. Furthermore, CHR was able to dock (with binding energy of -24.81
kcal/mol and predicted inhibition kinetic constant (Ki) of 0.959 &micro;M)
into the active site of SAM-dependent methyltransferase with strong
hydrogen bond and hydrophobic interactions. The study might have
unravelled the potentials of CHR against SA-induced chromosomal and DNA
damage, which might be due to inhibition of SAM-dependent
methyltransferase.
KW - DNA damage
KW - S-adenosyl methionine-dependent methyltransferase
KW - Sodium arsenite
KW - chrysin
KW - modelling
LA - eng
IS - 1477-0903 (Electronic)
PT - Journal Article
TA - Hum Exp Toxicol
YR - 2018
DATE- 20180108
CITO- NLM
CS - England
FJT - Human &amp; experimental toxicology
EDAT- 20180101
STAT- Publisher
DOCNO- medline/29308674

323 - TOXLINE
TI - Development of a kelp powder (Thallus laminariae) Standard Reference
Material.
AU - Yu LL
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA. lee.yu@nist.gov.
AU - Browning JF
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Burdette CQ
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Caceres GC
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Chieh KD
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Davis WC
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Kassim BL
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Long SE
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Murphy KE
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Oflaz R
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Paul RL
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Sharpless KE
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Wood LJ
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
AU - Yen JH
AD - Statistical Engineering Division, National Institute of Standards and
Technology, Gaithersburg, MD, 20899, USA.
AU - Zeisler R
AD - Chemical Sciences Division, National Institute of Standards and Technology,
Gaithersburg, MD, 20899, USA.
SO - Anal Bioanal Chem. 2018, Feb; 410(4):1265-1278. [Analytical and
bioanalytical chemistry]
AB - A Standard Reference Material (SRM) of seaweed, SRM 3232 Kelp Powder
(Thallus laminariae) has been developed to support food and dietary
supplement measurements in compliance with the Food Safety Modernization
Act (FSMA) and the Dietary Supplement Health and Education Act of 1994
(DSHEA). The material was characterized for nutritional minerals, arsenic
species, isomers of vitamin K1, proximates, and toxic elements. Kelp is a
rich source of vitamins and minerals, and it is an excellent source of
dietary iodine. Kelp also contains a large amount of arsenic, which is
toxic as inorganic species but much less so as organic species. To capture
the dietary profile of kelp, certified values were issued for As, Ca, Cd,
Cr, Cu, Fe, Hg, I, K, Mg, Mn, Mo, Na, Pb, and Zn. Reference values for
proximates were assigned. For the first time, a certified value for
iodine, reference values for isomers of vitamin K1, and reference values
for arsenic species including arsenosugars were assigned in a seaweed. SRM
3232 fills a gap in Certified Reference Materials (CRMs) needed for
quality assurance and method validation in the compositional measurements
of kelp and similar seaweeds used as food and as dietary supplements.
Graphical Absract Arsenic species and isomers of vitamin K1 were
determined in the development of SRM 3232 Kelp Powder (Thallus
laminariae).
KW - Arsenosugar
KW - Iodine
KW - Kelp
KW - Laminaria
KW - SRM
KW - Vitamin K1
LA - eng
IS - 1618-2650 (Electronic)
PT - Journal Article
TA - Anal Bioanal Chem
YR - 2018
DATE- 20180502
CITO- NLM
CS - Germany
CSET- IM
FJT - Analytical and bioanalytical chemistry
EDAT- 20171209
STAT- MEDLINE
DOCNO- medline/29222652

324 - TOXLINE
TI - Interaction of Sb(III) with iron sulfide under anoxic conditions:
Similarities and differences compared to As(III) interactions.
AU - Han YS
AD - Geologic Environment Division, Korea Institute of Geoscience and Mineral
Resources, 124 Gwahak-ro, Yuseong-gu, Daejeon, 34132, Republic of Korea.
AU - Seong HJ
AD - Department of Energy &amp; Resources Engineering, Korea Maritime and Ocean
University, 727 Taejong-ro, Yeongdo-Gu, Busan, 49112, Republic of Korea.
AU - Chon CM
AD - Geologic Environment Division, Korea Institute of Geoscience and Mineral
Resources, 124 Gwahak-ro, Yuseong-gu, Daejeon, 34132, Republic of Korea.
AU - Park JH
AD - School of Crop Science and Agricultural Chemistry, Chungbuk National
University, Cheongju, Chungbuk, 28644, Republic of Korea.
AU - Nam IH
AD - Geologic Environment Division, Korea Institute of Geoscience and Mineral
Resources, 124 Gwahak-ro, Yuseong-gu, Daejeon, 34132, Republic of Korea.
AU - Yoo K
AD - Department of Energy &amp; Resources Engineering, Korea Maritime and Ocean
University, 727 Taejong-ro, Yeongdo-Gu, Busan, 49112, Republic of Korea.
AU - Ahn JS
AD - Geologic Environment Division, Korea Institute of Geoscience and Mineral
Resources, 124 Gwahak-ro, Yuseong-gu, Daejeon, 34132, Republic of Korea. Electronic
address: jsahn@kigam.re.kr.
SO - Chemosphere. 2018, Mar; 195:762-770. [Chemosphere]
AB - This study examined the reaction mechanism of arsenite, As(III), and
antimonite, Sb(III), with iron sulfide and compared their pH-dependent
reaction behaviors under strictly anoxic environments. The comparison of
Sb(III) with As(III), based on their chemical similarity, may provide
useful insight into understanding the geochemical behavior of the less
studied Sb(III). The pH-dependent batch sorption studies revealed that
As(III) and Sb(III) displayed similar removal trends with pH in terms of
the removal efficiency. However, the aqueous As(III) species transformed
to thioarsenite species, while aqueous Sb(III) species remained inert
under the highly sulfidic anoxic system. An X-ray absorption spectroscopy
study demonstrated the reaction of As(III) and Sb(III) at acidic pH was
closely related to the precipitation of sulfide minerals As2S3 and Sb2S3,
respectively, as a consequence of the reaction with sulfide produced
through mackinawite dissolution. Meanwhile, the removal at basic pH was
inferred as a surface reaction, possibly through surface complexation,
surface-precipitation, or both. In this study, the pH-dependent Sb(III)
uptake mechanisms proved to be similar to the corresponding mechanisms for
As(III) uptake, with mackinawite demonstrating a superior capacity to
scavenge Sb(III) in ferrous and sulfide-rich reducing environments.
KW - Antimony
KW - Arsenic
KW - Iron sulfide
KW - Sulfide mineral
KW - Surface complexation
RN - 39349-74-1
RN - 9IT35J3UV3
RN - E1UOL152H7
RN - N5509X556J
RN - TH5J4TUX6S
LA - eng
IS - 1879-1298 (Electronic)
PT - Comparative Study
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180502
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171226
STAT- MEDLINE
DOCNO- medline/29289022

325 - TOXLINE
TI - Diminution of arsenic accumulation in rice seedlings co-cultured with
Anabaena sp.: Modulation in the expression of lower silicon transporters,
two nitrogen dependent genes and lowering of antioxidants activity.
AU - Ranjan R
AD - CSIR-National Botanical Research Institute, Lucknow, India; University of
Lucknow, Lucknow, India.
AU - Kumar N
AD - CSIR-National Botanical Research Institute, Lucknow, India.
AU - Dubey AK
AD - CSIR-National Botanical Research Institute, Lucknow, India.
AU - Gautam A
AD - CSIR-National Botanical Research Institute, Lucknow, India.
AU - Pandey SN
AD - University of Lucknow, Lucknow, India.
AU - Mallick S
AD - CSIR-National Botanical Research Institute, Lucknow, India. Electronic
address: shekharm@nbri.res.in.
SO - Ecotoxicol Environ Saf. 2018, Apr 30; 151:109-117. [Ecotoxicology and
environmental safety]
AB - The present study was intended to investigate the role of algae, Anabaena
sp. in the amelioration of As toxicity, when co-cultured with rice
seedlings. The reduction of growth in rice seedlings against As(III) and
As(V) was recovered with Anabaena sp. The Anabaena sp. also reduced the
accumulation of As, where it was more efficient against 60&micro;M As(III)
(49%) than As(V) (23%) in rice shoot. Similarly, with reduction of As
accumulation, lower silicon transporters (Lsi-1 and Lsi-2) was found to be
suppressed against As treatments. However, the expression of two nitrogen
dependent genes i.e., NR and SAMT were found to be enhanced with the
Anabaena sp. Likewise, the activity of antioxidant enzyme, GST, was
enhanced, whereas, the activity of other enzymes such as SOD, APX, GPX, GR
and DHAR were decreased with As+Algae combinations. Overall, the result
suggested that the Anabaena sp. reduces As accumulation, modulates gene
expressions and antioxidants to ameliorate the As toxicity in Oryza sativa
L.
KW - Anabaena sp.
KW - Arsenic
KW - Lower silicon transporter
KW - Oryza sativa L.
KW - S-adenosylmethionine-dependent methyltransferases
RN - N712M78A8G
RN - N762921K75
RN - Z4152N8IUI
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180530
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180110
STAT- MEDLINE
DOCNO- medline/29331724

326 - TOXLINE
TI - Exposure to toxic metals triggers unique responses from the rat gut
microbiota.
AU - Richardson JB
AD - Center for Genome Sciences, United States Army Medical Research Institute of
Infectious Diseases, Fort Detrick, MD, 21702, USA.
joshua.b.richardson2.ctr@mail.mil.
AU - Dancy BCR
AD - United States Army Center for Environmental Health Research, Fort Detrick,
MD, 21702, USA.
AU - Horton CL
AD - United States Army Center for Environmental Health Research, Fort Detrick,
MD, 21702, USA.
AU - Lee YS
AD - United States Army Center for Environmental Health Research, Fort Detrick,
MD, 21702, USA.
AU - Madejczyk MS
AD - United States Army Center for Environmental Health Research, Fort Detrick,
MD, 21702, USA.
AU - Xu ZZ
AD - Department of Pediatrics, University of California, San Diego, La Jolla, CA,
92093, USA.
AU - Ackermann G
AD - Department of Pediatrics, University of California, San Diego, La Jolla, CA,
92093, USA.
AU - Humphrey G
AD - Department of Pediatrics, University of California, San Diego, La Jolla, CA,
92093, USA.
AU - Palacios G
AD - Center for Genome Sciences, United States Army Medical Research Institute of
Infectious Diseases, Fort Detrick, MD, 21702, USA.
AU - Knight R
AD - Center for Microbiome Innovation, University of California, San Diego, La
Jolla, CA, 92093, USA.
AU - Lewis JA
AD - United States Army Center for Environmental Health Research, Fort Detrick,
MD, 21702, USA.
SO - Sci Rep. 2018, Apr 26; 8(1):6578. [Scientific reports]
AB - Our understanding of the interaction between the gut microbiota and host
health has recently improved dramatically. However, the effects of toxic
metal exposure on the gut microbiota remain poorly characterized. As this
microbiota creates a critical interface between the external environment
and the host's cells, it may play an important role in host outcomes
during exposure. We therefore used 16S ribosomal RNA (rRNA) gene
sequencing to track changes in the gut microbiota composition of rats
exposed to heavy metals. Rats were exposed daily for five days to arsenic,
cadmium, cobalt, chromium, nickel, or a vehicle control. Significant
changes to microbiota composition were observed in response to high doses
of chromium and cobalt, and significant dose-dependent changes were
observed in response to arsenic, cadmium and nickel. Many of these
perturbations were not uniform across metals. However, bacteria with
higher numbers of iron-importing gene orthologs were overly represented
after exposure to arsenic and nickel, suggesting some possibility of a
shared response. These findings support the utility of the microbiota as a
pre-clinical tool for identifying exposures to specific heavy metals. It
is also clear that characterizing changes to the functional capabilities
of microbiota is critical to understanding responses to metal exposure.
LA - eng
IS - 2045-2322 (Electronic)
PT - Journal Article
TA - Sci Rep
YR - 2018
DATE- 20180503
CITO- NLM
CS - England
FJT - Scientific reports
EDAT- 20180426
STAT- In-Data-Review
CM - Cites: Genome Biol. 2011 Jun 24;12(6):R60 (medline /21702898)
CM - Cites: Toxicol Appl Pharmacol. 2015 Dec 15;289(3):397-408 (medline
/26529668)
CM - Cites: EXS. 2012;101:133-64 (medline /22945569)
CM - Cites: Science. 2009 Dec 18;326(5960):1694-7 (medline /19892944)
CM - Cites: Curr Med Chem. 2014;21(33):3721-40 (medline /25039781)
CM - Cites: Environ Pollut. 2017 Mar;222:1-9 (medline /28086130)
CM - Cites: Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5 (medline
/16033867)
CM - Cites: Nature. 2012 Jun 13;486(7402):207-14 (medline /22699609)
CM - Cites: Lancet Oncol. 2009 May;10(5):453-4 (medline /19418618)
CM - Cites: Science. 2012 Jun 8;336(6086):1268-73 (medline /22674334)
CM - Cites: BMC Pharmacol Toxicol. 2013 Dec 11;14:62 (medline /24325943)
CM - Cites: ISME J. 2012 Aug;6(8):1621-4 (medline /22402401)
CM - Cites: Front Cell Infect Microbiol. 2013 Dec 09;3:94 (medline /24367767)
CM - Cites: Inflamm Bowel Dis. 2016 Apr;22(4):817-25 (medline /26937623)
CM - Cites: Food Funct. 2016 Aug 10;7(8):3524-30 (medline /27425201)
CM - Cites: Microbiome. 2016 Jul 07;4(1):36 (medline /27388460)
CM - Cites: PLoS One. 2014 Feb 03;9(2):e85323 (medline /24498261)
CM - Cites: Bioinformatics. 2010 Jan 15;26(2):266-7 (medline /19914921)
CM - Cites: Nat Methods. 2010 May;7(5):335-6 (medline /20383131)
CM - Cites: PLoS One. 2013 Apr 22;8(4):e61217 (medline /23630581)
CM - Cites: Chemosphere. 2014 Oct;112:1-8 (medline /25048881)
CM - Cites: Environ Health Perspect. 2012 Mar;120(3):332-9 (medline /22042266)
CM - Cites: NPJ Biofilms Microbiomes. 2016 May 04;2:16003 (medline /28721242)
CM - Cites: MBio. 2014 Oct 07;5(5):e01580-14 (medline /25293764)
CM - Cites: Science. 2005 Jun 10;308(5728):1635-8 (medline /15831718)
CM - Cites: Microbiome. 2015 Nov 16;3:53 (medline /26568112)
CM - Cites: PLoS Comput Biol. 2014 Apr 03;10(4):e1003531 (medline /24699258)
CM - Cites: Appl Environ Microbiol. 2005 Dec;71(12):8228-35 (medline /16332807)
CM - Cites: Nat Biotechnol. 2013 Sep;31(9):814-21 (medline /23975157)
CM - Cites: Dis Model Mech. 2015 Jan;8(1):1-16 (medline /25561744)
CM - Cites: Bioinformatics. 2010 Jun 1;26(11):1463-4 (medline /20395285)
CM - Cites: Cell. 2014 Aug 14;158(4):705-721 (medline /25126780)
CM - Cites: ISME J. 2014 Jul;8(7):1403-17 (medline /24500617)
CM - Cites: Cell. 2012 Mar 16;148(6):1258-70 (medline /22424233)
CM - Cites: Cell Host Microbe. 2015 May 13;17(5):592-602 (medline /25974301)
CM -Cites: Bioinformatics. 2010 Oct 1;26(19):2460-1 (medline /20709691)
CM -Cites: Diabetes Care. 2015 Jan;38(1):159-65 (medline /25538312)
CM -Cites: Can J Microbiol. 2008 Mar;54(3):163-72 (medline /18388987)
CM -Cites: Ecotoxicol Environ Saf. 2014 Nov;109:70-6 (medline /25164205)
CM -Cites: Environ Health Perspect. 2014 Mar;122(3):284-91 (medline /24413286)
CM -Cites: Genome Biol. 2013 Jan 24;14(1):R4 (medline /23347395)
CM -Cites: ISME J. 2012 Mar;6(3):610-8 (medline /22134646)
CM -Cites: ISME J. 2013 Nov;7(11):2116-25 (medline /23823492)
CM -Cites: IARC Monogr Eval Carcinog Risks Hum. 2006;86:1-294 (medline
/16906675)
CM - Cites: Genome Biol. 2014;15(12):550 (medline /25516281)
DOCNO- medline/29700420

327 - TOXLINE
TI - Blood Mercury, Arsenic, Cadmium, and Lead in Children with Autism Spectrum
Disorder.
AU - Li H
AD - Children's Hospital of Zhejiang University School of Medicine, Hangzhou,
People's Republic of China.
AU - Li H
AD - Laboratory of Neuroinflammation, StVincent's Centre for Applied Medical
Research and University of New South Wales, Sydney, NSW, Australia.
AU - Li Y
AD - Children's Hospital of Zhejiang University School of Medicine, Hangzhou,
People's Republic of China.
AU - Liu Y
AD - Children's Hospital of Zhejiang University School of Medicine, Hangzhou,
People's Republic of China.
AU - Zhao Z
AD - Department of Pediatric Health Care, Children's Hospital of Zhejiang
University School of Medicine, 57 Zhuganxiang Road, Hangzhou, People's Republic of
China, 310003. zhaozy@zju.edu.cn.
SO - Biol Trace Elem Res. 2018, Jan; 181(1):31-37. [Biological trace element
research]
AB - Environmental factors have been implicated in the etiology of autism
spectrum disorder (ASD); however, the role of heavy metals has not been
fully defined. This study investigated whether blood levels of mercury,
arsenic, cadmium, and lead of children with ASD significantly differ from
those of age- and sex-matched controls. One hundred eighty unrelated
children with ASD and 184 healthy controls were recruited. Data showed
that the children with ASD had significantly (p < 0.001)
higher levels of mercury and arsenic and a lower level of cadmium. The
levels of lead did not differ significantly between the groups. The
results of this study are consistent with numerous previous studies,
supporting an important role for heavy metal exposure, particularly
mercury, in the etiology of ASD. It is desirable to continue future
research into the relationship between ASD and heavy metal exposure.
KW - Autism spectrum disorder
KW - Developmental neurotoxicity
KW - Heavy metals
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20171230
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170508
STAT- In-Process
DOCNO- medline/28480499

328 - TOXLINE
TI - Comparision of photocatalysis and photolysis processes for arsenic
oxidation in water.
AU - Fontana KB
AD - Universidade Tecnol�gica Federal do Paran�, Departamento de Engenharia
Qu�mica, Av. Monteiro Lobato s / n, CEP: 84016-210 Ponta Grossa, Paran�, Brasil.
AU - Lenzi GG
AD - Universidade Tecnol�gica Federal do Paran�, Departamento de Engenharia
Qu�mica, Av. Monteiro Lobato s / n, CEP: 84016-210 Ponta Grossa, Paran�, Brasil.
Electronic address: gianeg@utfpr.edu.br.
AU - Se�ra ECR
AD - Universidade Tecnol�gica Federal do Paran�, Departamento de Engenharia
Qu�mica, Av. Monteiro Lobato s / n, CEP: 84016-210 Ponta Grossa, Paran�, Brasil.
AU - Chaves ES
AD - Universidade Tecnol�gica Federal do Paran�, Departamento de Engenharia
Qu�mica, Av. Monteiro Lobato s / n, CEP: 84016-210 Ponta Grossa, Paran�, Brasil.
SO - Ecotoxicol Environ Saf. 2018, Apr 30; 151:127-131. [Ecotoxicology and
environmental safety]
AB - The oxidation of As(III) to As(V) in aqueous solution was evaluated using
heterogeneous photocatalysis and photolysis. The influence of TiO2 as
catalyst in different crystalline (rutile, anatase) and commercial forms
was evaluated in a batch reactor and an insignificant difference was
observed between them. The process by photocatalysis reached up to 97%
As(III) oxidation and no significant difference was observed comparing to
results obtained by photolysis. The photolysis experiments (UV radiation
only), also carried out in a batch system, showed a high oxidation rate of
As(III) (90% in 20min). The influence of different matrices (well water,
river water and public water supply) were evaluated. Additionally, the
effect of As(V) concentration, generated during the oxidation process, was
studied. Continuous photolysis experiments using only UV radiation were
performed, resulting in a high As(III) oxidation rate. Using a flow rate
of 5mLmin-1 and an initial concentration of As(III) 200&micro;gL-1, gave
an oxidation percentage of As(III) of up to 72%, showing a simple and
economical alternative to the oxidation step of As(III) to As(V) in the
treatment of water contaminated with arsenic.
KW - Arsenic oxidation
KW - Heterogeneous photocatalysis
KW - Photolysis
KW - Titanium dioxide
RN - 059QF0KO0R
RN - 15FIX9V2JP
RN - D1JT611TNE
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Comparative Study
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180530
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180111
STAT- MEDLINE
DOCNO- medline/29331917

329 - TOXLINE
TI - Environmental behavior, potential phytotoxicity, and accumulation of
copper oxide nanoparticles and arsenic in rice plants.
AU - Liu J
AD - Department of Environmental Science, Baylor University, Waco, Texas, USA.
AU - Dhungana B
AD - Department of Environmental Science, Baylor University, Waco, Texas, USA.
AU - Cobb GP
AD - Department of Environmental Science, Baylor University, Waco, Texas, USA.
SO - Environ Toxicol Chem. 2018, Jan; 37(1):11-20. [Environmental toxicology
and chemistry]
AB - Copper oxide nanoparticles (CuO NPs) are widely used in many industries.
The increasing release of CuO NPs from both intentional and unintentional
sources into the environment may pose risks to rice plants, thereby
reducing the quality or quantity of this staple grain in the human diet.
Not only has arsenic (As) contamination decreased rice yield, but As
accumulation in rice has also been a great human health concern for a few
decades. New technologies have succeeded in removing As from water by
nanomaterials. By all accounts, few studies have addressed CuO NP
phytotoxicity to rice, and the interactions of CuO NPs with As are poorly
described. The present study 1) reviews studies about the environmental
behavior and phytotoxicity of CuO NPs and As and research about the
interaction of CuO NPs with As in the environment, 2) discusses critically
the potential mechanisms of CuO NP and As toxicity in plants and their
interaction, and 3) proposes future research directions for solving the As
problem in rice. Environ Toxicol Chem 2018;37:11-20. &copy; 2017 SETAC.
KW - Arsenic
KW - Bioaccumulation
KW - Copper oxide nanoparticle
KW - Phytotoxicity
KW - Rice
KW - Speciation
LA - eng
IS - 1552-8618 (Electronic)
PT - Journal Article
PT - Review
TA - Environ Toxicol Chem
YR - 2018
DATE- 20171228
CI - &copy; 2017 SETAC.
CITO- NLM
CS - United States
FJT - Environmental toxicology and chemistry
EDAT- 20171110
STAT- In-Data-Review
DOCNO- medline/28796373

330 - TOXLINE
TI - Arsenic, cadmium, and mercury-induced hypertension: mechanisms and
epidemiological findings.
AU - da Cunha Martins A Jr
AD - a Laborat�rio de Toxicologia e Essencialidade de Metais, Depto. de An�lises
Cl�nicas, Toxicol�gicas e Bromatol�gicas, Faculdade de Ci�ncias Farmac�uticas de
Ribeir�o Preto , Universidade de S�o Paulo , Ribeir�o Preto-SP , Brazil.
AU - Carneiro MFH
AD - a Laborat�rio de Toxicologia e Essencialidade de Metais, Depto. de An�lises
Cl�nicas, Toxicol�gicas e Bromatol�gicas, Faculdade de Ci�ncias Farmac�uticas de
Ribeir�o Preto , Universidade de S�o Paulo , Ribeir�o Preto-SP , Brazil.
AU - Grotto D
AD - b Laborat�rio de Pesquisa em Toxicologia , Universidade de Sorocaba ,
Sorocaba-SP , Brazil.
AU - Adeyemi JA
AD - a Laborat�rio de Toxicologia e Essencialidade de Metais, Depto. de An�lises
Cl�nicas, Toxicol�gicas e Bromatol�gicas, Faculdade de Ci�ncias Farmac�uticas de
Ribeir�o Preto , Universidade de S�o Paulo , Ribeir�o Preto-SP , Brazil.
AU - Barbosa F Jr
AD - a Laborat�rio de Toxicologia e Essencialidade de Metais, Depto. de An�lises
Cl�nicas, Toxicol�gicas e Bromatol�gicas, Faculdade de Ci�ncias Farmac�uticas de
Ribeir�o Preto , Universidade de S�o Paulo , Ribeir�o Preto-SP , Brazil.
SO - J Toxicol Environ Health B Crit Rev. 2018; 21(2):61-82. [Journal of
toxicology and environmental health. Part B, Critical reviews]
AB - Arsenic (As), cadmium (Cd), and mercury (Hg) are toxic elements widely
distributed in the environment. Exposure to these elements was attributed
to produce several acute and chronic illnesses including hypertension. The
aim of this review is to provide a summary of the most frequently proposed
mechanisms underlying hypertension associated with As, Cd, and Hg exposure
including: oxidative stress, impaired nitric oxide (NO) signaling,
modified vascular response to neurotransmitters and disturbed vascular
muscle Ca2+ signaling, renal damage, and interference with the
renin-angiotensin system. Due to the complexity of the vascular system, a
combination rather than a singular mechanism needs to be considered. In
addition, epidemiological findings showing the relationship between
various biomarkers of metal exposure and hypertension are described. Given
the complex etiology of hypertension, further epidemiological studies
evaluating the roles of confounding factors such as age, gender, and life
style are still necessary.
LA - eng
IS - 1521-6950 (Electronic)
PT - Journal Article
TA - J Toxicol Environ Health B Crit Rev
YR - 2018
DATE- 20180531
CITO- NLM
CS - England
FJT - Journal of toxicology and environmental health. Part B, Critical reviews
EDAT- 20180215
STAT- In-Data-Review
DOCNO- medline/29446707

331 - TOXLINE
TI - DNA methylation of a non-CpG island promoter represses NQO1 expression in
rat arsenic-transformed lung epithelial cells.
AU - Huang N
AD - State Key Laboratory of Cellular Stress Biology, School of Life Sciences,
Xiamen University, Xiamen, China.
AU - Pei X
AD - Department of Pathology, Shenzhen Hospital of Southern Medical University,
Shenzhen, China.
AU - Lin W
AD - State Key Laboratory of Cellular Stress Biology, School of Life Sciences,
Xiamen University, Xiamen, China.
AU - Chiu JF
AD - School of Biomedical Sciences, LKS Faculty of Medicine, University of Hong
Kong, Hong Kong, China.
AU - Tao T
AD - State Key Laboratory of Cellular Stress Biology, School of Life Sciences,
Xiamen University, Xiamen, China.
AU - Li G
AD - Department of Biochemistry, The Key Lab of Molecular Biology for High Cancer
Incidence Coastal Chaoshan Area, Shantou University Medical College, Shantou,
China.
SO - Acta Biochim Biophys Sin (Shanghai). 2018, Jun 08. [Acta biochimica et
biophysica Sinica]
AB - NAD(P)H:quinone oxidoreductase 1 (NQO1), a phase II flavoenzyme that
catalyzes reduction reactions to protect cells against electrophiles and
oxidants, is involved in tumorigenesis. Altered methylation of the NQO1
gene has been observed and is speculated to result in aberrant NQO1
expression in rat cells undergoing chemical carcinogenesis, although this
has not been proven experimentally. In this study, we first investigated
the potential epigenetic mechanisms underlying the phenomenon of NQO1
differential expression in individual subclones of rat arsenic-transformed
lung epithelial cells (TLECs). NQO1 expression of TLEC subclones with or
without 5-aza-2'-deoxycytidine (5-Aza-CdR) treatment was assessed by
reverse transcriptase-polymerase chain reaction (RT-PCR), western blot
analysis, and real-time PCR. Methylation status of the NQO1 promoter in
TLEC subclones was analyzed by bisulfite sequencing. Transcriptional
activity of NQO1 promoter in vitro methylated was determined by luciferase
assay using a CpG-free luciferase reporter driven by the NQO1 promoter
region (-435 to +229). We found that non-CpG island (non-CpGI) within the
NQO1 promoter was hyper- or hypo-methylated in TLEC subclones and
corresponded to low and high gene expressions, respectively. Following the
treatment with 5-Aza-CdR, transcription of the NQO1 gene in the
hypermethylated subclones was restored, accompanied by demethylation of
the NQO1 promoter. In vitro promoter methylation almost completely
silenced reporter activity in TLECs. These results indicate that DNA
methylation of the non-CpGI promoter contributes to epigenetic silencing
of NQO1 in rat TLECs.
LA - eng
IS - 1745-7270 (Electronic)
PT - Journal Article
TA - Acta Biochim Biophys Sin (Shanghai)
YR - 2018
DATE- 20180611
CITO- NLM
CS - China
FJT - Acta biochimica et biophysica Sinica
EDAT- 20180608
STAT- Publisher
DOCNO- medline/29889218

332 - TOXLINE
TI - Supercritical water treatment of heavy metal and arsenic
metalloid-bioaccumulating-biomass.
AU - Li J
AD - Institute of Energy and Environmental Engineering, Ningbo Institute of
Technology, Zhejiang University, Ningbo 315000, China.
AU - Chen J
AD - Institute of Energy and Environmental Engineering, Ningbo Institute of
Technology, Zhejiang University, Ningbo 315000, China. Electronic address:
mrchen@nit.net.cn.
AU - Chen S
AD - Institute of Energy and Environmental Engineering, Ningbo Institute of
Technology, Zhejiang University, Ningbo 315000, China; School of Energy
Engineering, Zhejiang University, Hangzhou 310000, China.
SO - Ecotoxicol Environ Saf. 2018, Aug 15; 157:102-110. [Ecotoxicology and
environmental safety]
AB - Hyperaccumulator biomass, as a promising resource for renewable energy
that can be converted into valuable fuel productions with high conversion
efficiency, must be considered as hazardous materials and be carefully
treated before further reuse due to the high contents of heavy metals. In
this study, Pteris vittata L., an As-hyperaccumulator biomass was treated
by an effective and environmental friendly method-supercritical water
gasification (SCWG) using a bench-scale batch reactor. The contents of
heavy metals (Cd, Pb and Zn) and arsenic metalloid in solid, liquid and
gaseous products during SCWG process were thoroughly investigated. The
speciation fractions including exchangeable, reducible, oxidizable and
residual fractions of each heavy metal as the proportion of the total
contents in solid residue were presented and the transformations trend of
these heavy metals during the SCWG process was especially demonstrated.
The significant operating parameters, including reaction temperature
(395-445&#8239;&deg;C), pressure (21-27&#8239;MPa) and residence time
(0-40&#8239;min) were varied to explore their effects on the contents and
forms. Moreover, the environmental risks of heavy metals in solid residues
were evaluated based on risk assessment code, taking into consideration
the speciation fractions and bioavailability. It was highlighted that
although heavy metals particularly Pb and Zn tended to accumulate in solid
residues with a maximum increment of about 50% in the total content, they
were mostly converted to more stable oxidizable and residual fractions,
and thus the ecotoxicity and bioavailability were greatly mitigated with
no obvious increase in direct toxicity fractions. Each tested heavy metal
presented no or low risk to the environments after SCWG treatments,
meaning that the environmental pollution levels were markedly reduced with
no or low risk to the environment. This study highlights the remarkable
ability of SCWG for the heavy metal stabilization.
KW - Heavy metals
KW - Hyperaccumulator biomass
KW - Stabilization
KW - Supercritical water
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180424
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180331
STAT- In-Process
DOCNO- medline/29609106

333 - TOXLINE
TI - Intracellular Mechanism by which Arsenite Activates Yeast Stress MAPK
Hog1.
AU - Lee J
AD - Department of Molecular and Cell Biology, Boston University Goldman School of
Dental Medicine, Boston, Massachusetts, USA.
AU - Levin DE
AD - Department of Microbiology Boston University School of Medicine, Boston,
Massachusetts, USA.
SO - Mol Biol Cell. 2018, May 30:mbcE18030185. [Molecular biology of the cell]
AB - Stress-activated MAPKs (SAPKs) respond to a wide variety of stressors. In
most cases, the pathways through which specific stress signals are
transmitted to the SAPKs are not known. In this study, we delineate the
intracellular signaling pathway by which the trivalent toxic metalloid
arsenite [As(III)] activates the yeast SAPK Hog1. We demonstrate that, to
activate Hog1, As(III) must enter the cell through the glycerol channel
Fps1 and requires metabolism to methylarsenite [MAs(III)] by the dimeric
methyltransferase Mtq2:Trm112. We found that Mtq2:Trm1 displays
SAM-dependent methyltransferase activity toward both As(III) and MAs(III).
Additionally, we present genetic and biochemical evidence that MAs(III),
but not As(III), is a potent inhibitor of the protein tyrosine
phosphatases (Ptp2 and Ptp3) that normally maintain Hog1 in an inactive
state. Inhibition of Ptp2 and Ptp3 by MAs(III) results in elevated Hog1
phosphorylation without activation of the protein kinases that act
upstream of the SAPK and raises the possibility that other Hog1-activating
stressors act intracellularly at different points along the canonical Hog1
activation pathway. Finally, we show that arsenate [As(V)], a pentavalent
form of arsenic, also activates Hog1, but though a pathway that is
distinct from that of As(III) and involves activation of the Hog1 MEK
Pbs2.
LA - eng
IS - 1939-4586 (Electronic)
PT - Journal Article
TA - Mol Biol Cell
YR - 2018
DATE- 20180530
CITO- NLM
CS - United States
FJT - Molecular biology of the cell
EDAT- 20180530
STAT- Publisher
DOCNO- medline/29846136

334 - TOXLINE
TI - Heavy metal contamination and health risk assessment in three commercial
fish species in the Persian Gulf.
AU - Keshavarzi B
AD - Department of Earth Sciences, College of Sciences, Shiraz University, Shiraz
71454, Iran. Electronic address: bkeshavarzi@shirazu.ac.ir.
AU - Hassanaghaei M
AD - Department of Earth Sciences, College of Sciences, Shiraz University, Shiraz
71454, Iran.
AU - Moore F
AD - Department of Earth Sciences, College of Sciences, Shiraz University, Shiraz
71454, Iran.
AU - Rastegari Mehr M
AD - Department of Applied Geology, Faculty of Earth Science, Kharazmi University,
Tehran 15614, Iran.
AU - Soltanian S
AD - Aquatic Animal Health and Diseases of Veterinary Medicine, Shiraz University,
Shiraz 71441-69155, Iran.
AU - Lahijanzadeh AR
AD - Khuzestan Environmental Protection Office, Ahvaz, Iran.
AU - Sorooshian A
AD - Department of Chemical and Environmental Engineering, University of Arizona,
Tucson, AZ 85721, USA; Department of Hydrology and Atmospheric Sciences, University
of Arizona, Tucson, AZ 85721, USA.
SO - Mar Pollut Bull. 2018, Apr; 129(1):245-252. [Marine pollution bulletin]
AB - Five heavy metals/metalloids and related potential health risks were
investigated in three commercially important fish species (Anodontostoma
chacunda, Belangerii, and Cynoglossurs arel) in Musa Estuary and Mahshahr
Harbour of the Persian Gulf. A total of 116 fish samples were collected,
and their liver and muscle organs were separately analyzed using ICP-MS.
Results revealed that studied metals concentrations (with some exceptions)
varied among sampling stations, fish species and their organs. Human
health risk is evaluated using different indices. The results indicated
that arsenic and mercury are the most hazardous elements. Estimated daily
intake (EDI) for the metals exceeded the provisional tolerable daily
intake (PTDI) for all studied fish species. Also, target risk (TR) of
arsenic indicated that consumption over a long period of time may result
in a carcinogenic effect. The results are expected to create awareness
among the public on the safety of consuming food products grown in
particular areas.
KW - Carcinogenic risk
KW - Commercial fish
KW - Contamination
KW - Health risk
KW - Heavy metals
LA - eng
IS - 1879-3363 (Electronic)
PT - Journal Article
TA - Mar Pollut Bull
YR - 2018
DATE- 20180422
CI - Copyright &copy; 2018. Published by Elsevier Ltd.
CITO- NLM
CS - England
FJT - Marine pollution bulletin
EDAT- 20180227
STAT- In-Process
DOCNO- medline/29680544

335 - TOXLINE
TI - Endocrine active metals, prenatal stress and enhanced neurobehavioral
disruption.
AU - Sobolewski M
AD - Dept. of Environmental Medicine, University of Rochester School of Medicine,
Rochester, NY, United States. Electronic address:
marissa:sobolewski@urmc.rochester.edu.
AU - Conrad K
AD - Dept. of Environmental Medicine, University of Rochester School of Medicine,
Rochester, NY, United States.
AU - Marvin E
AD - Dept. of Environmental Medicine, University of Rochester School of Medicine,
Rochester, NY, United States.
AU - Allen JL
AD - Dept. of Environmental Medicine, University of Rochester School of Medicine,
Rochester, NY, United States.
AU - Cory-Slechta DA
AD - Dept. of Environmental Medicine, University of Rochester School of Medicine,
Rochester, NY, United States.
SO - Horm Behav. 2018, May; 101:36-49. [Hormones and behavior]
AB - Metals, including lead (Pb), methylmercury (MeHg) and arsenic (As), are
long-known developmental neurotoxicants. More recently, environmental
context has been recognized to modulate metals toxicity, including
nutritional state and stress exposure. Modulation of metal toxicity by
stress exposure can occur through shared targeting of endocrine systems,
such as the hypothalamic-pituitary-adrenal axis (HPA). Our previous rodent
research has identified that prenatal stress (PS) modulates neurotoxicity
of two endocrine active metals (EAMs), Pb and MeHg, by altering HPA and
CNS systems disrupting behavior. Here, we review this research and further
test the hypothesis that prenatal stress modulates metals neurotoxicity by
expanding to test the effect of developmental As&#8239;&plusmn;&#8239;PS
exposure. Serum corticosterone and behavior was assessed in offspring of
dams exposed to As&#8239;&plusmn;&#8239;PS. PS increased female offspring
serum corticosterone at birth, while developmental As exposure decreased
adult serum corticosterone in both sexes. As&#8239;+&#8239;PS induced
reductions in locomotor activity in females and reduced response rates on
a Fixed Interval schedule of reinforcement in males, with the latter
suggesting unique learning deficits only in the combined exposure.
As-exposed males showed increased time in the open arms of an elevated
plus maze and decreased novel object recognition whereas females did not.
These data further confirm the hypothesis that combined exposure to
chemical (EAMs) and non-chemical (PS) stressors results in enhanced
neurobehavioral toxicity. Given that humans are exposed to multiple
environmental risk factors that alter endocrine function in development,
such models are critical for risk assessment and public health protection,
particularly for children.
KW - Arsenic
KW - Behavior
KW - Corticosterone
KW - Lead
KW - Metals
KW - Methylmercury
KW - Prenatal stress
LA - eng
IS - 1095-6867 (Electronic)
PT - Journal Article
TA - Horm Behav
YR - 2018
DATE- 20180529
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Hormones and behavior
EDAT- 20180201
STAT- In-Data-Review
CM - Cites: Toxicol Sci. 2017 Apr 1;156(2):492-508 (medline /28087836)
CM - Cites: Environ Health Perspect. 2005 Jul;113(7):894-9 (medline /16002379)
CM - Cites: Epigenetics. 2017 Jan 2;12 (1):1-10 (medline /27830979)
CM - Cites: Toxicol Appl Pharmacol. 2000 Jul 1;166(1):1-12 (medline /10873713)
CM - Cites: Neurotoxicology. 2008 Nov;29(6):928-39 (medline /18951918)
CM - Cites: Toxicol Sci. 2017 Sep 1;159(1):137-158 (medline /28903487)
CM - Cites: Toxicol Appl Pharmacol. 2009 Jan 1;234(1):117-27 (medline
/18977374)
CM - Cites: Neurobiol Learn Mem. 2007 Mar;87(3):385-90 (medline /17118678)
CM - Cites: Cogn Process. 2012 May;13(2):93-110 (medline /22160349)
CM - Cites: Neurotoxicology. 2000 Dec;21(6):1069-80 (medline /11233753)
CM - Cites: Neurotoxicol Teratol. 1988 Nov-Dec;10(6):497-503 (medline /3244341)
CM - Cites: Neurotoxicology. 2016 May;54:65-71 (medline /27018513)
CM - Cites: Semin Reprod Med. 2009 Sep;27(5):358-68 (medline /19711246)
CM - Cites: Toxicol Sci. 2010 Oct;117(2):427-38 (medline /20639260)
CM - Cites: Infant Behav Dev. 2007 Feb;30(1):134-45 (medline /17292786)
CM - Cites: Endocr Rev. 2012 Jun;33(3):378-455 (medline /22419778)
CM - Cites: Neurochem Res. 2002 Nov;27(11):1525-33 (medline /12512957)
CM - Cites: Chem Res Toxicol. 2006 Dec;19(12):1619-29 (medline /17173375)
CM - Cites: Synapse. 2009 Sep;63(9):794-804 (medline /19489049)
CM - Cites: J Commun Disord. 2015 Sep-Oct;57:41-65 (medline /26255253)
CM - Cites: Neurotoxicology. 1990 Fall;11(3):427-41 (medline /2284049)
CM - Cites: J Pharmacol Exp Ther. 1998 Aug;286(2):794-805 (medline /9694936)
CM - Cites: Neurotoxicology. 2005 Aug;26(4):491-510 (medline /16112317)
CM - Cites: Int J Hyg Environ Health. 2016 Nov;219(8):832-842 (medline
/27503636)
CM - Cites: J Toxicol. 2016;2016:4763434 (medline /27375740)
CM - Cites: Nat Rev Neurosci. 2009 Jun;10(6):434-45 (medline /19401723)
CM - Cites: Endocrinology. 2008 Oct;149(10):4892-900 (medline /18566122)
CM - Cites: Brain Res. 2006 Sep 27;1112(1):91-8 (medline /16904659)
CM - Cites: EBioMedicine. 2015 May 01;2(6):536-43 (medline /26288817)
CM - Cites: J Pediatr. 2017 Jun;185:218-223 (medline /28258736)
CM - Cites: Environ Health Perspect. 2007 Sep;115(9):1371-5 (medline /17805430)
CM - Cites: J Neurosci Methods. 1985 Aug;14(3):149-67 (medline /2864480)
CM - Cites: Ergeb Physiol. 1968;60:1-56 (medline /4874179)
CM - Cites: Neurotoxicology. 2008 Jul;29(4):647-55 (medline /18573533)
CM - Cites: Am J Med. 2016 Nov;129(11):1213-1218 (medline /27341956)
CM - Cites: Exp Neurol. 2016 Jul;281:66-80 (medline /27094122)
CM - Cites: J Reprod Fertil. 1993 Nov;99(2):283-90 (medline /8107008)
CM - Cites: Environ Health. 2017 Jun 14;16(1):59 (medline /28615018)
CM - Cites: Behav Brain Res. 2015 Mar 15;281:1-8 (medline /25496779)
CM - Cites: Bull Environ Contam Toxicol. 2008 Dec;81(6):539-42 (medline
/18787750)
CM - Cites: Toxicology. 2013 Jun 7;308:20-33 (medline /23537661)
CM - Cites: Psychoneuroendocrinology. 2014 Sep;47:31-42 (medline /25001954)
CM - Cites: Psychopharmacology (Berl). 2011 Mar;214(1):107-20 (medline
/21088961)
CM - Cites: J Neurosci. 2009 Oct 14;29(41):12815-23 (medline /19828794)
CM - Cites: J Racial Ethn Health Disparities. 2016 Mar;3(1):145-53 (medline
/26896114)
CM - Cites: Neurotoxicology. 2011 Jan;32(1):83-99 (medline /20875452)
CM - Cites: Int J Dev Neurosci. 2003 Feb;21(1):1-12 (medline /12565691)
CM - Cites: J Am Chem Soc. 2008 Jul 2;130(26):8148-9 (medline /18529053)
CM - Cites: Neurotoxicol Teratol. 2009 Sep-Oct;31(5):312-7 (medline /19464365)
CM - Cites: Annu Rev Pharmacol Toxicol. 2004;44:525-57 (medline /14744257)
CM - Cites: Environ Health. 2014 Jun 10;13(1):50 (medline /24916609)
CM - Cites: J Vis Exp. 2008 Dec 22;(22):null (medline /19229173)
CM - Cites: J Neurosci Res. 2004 May 15;76(4):488-96 (medline /15114621)
CM - Cites: Neurotoxicology. 2014 Mar;41:123-40 (medline /24502960)
CM - Cites: Environ Health Perspect. 2004 May;112(6):717-30 (medline /15121516)
CM - Cites: Dev Neuropsychol. 2004;26(1):513-40 (medline /15276907)
CM - Cites: Sci Total Environ. 2013 Jun 1;454-455:562-77 (medline /23570911)
CM - Cites: Cortex. 2016 Jan;74:358-69 (medline /26109549)
CM - Cites: Toxicol Sci. 2007 Jul;98(1):75-86 (medline /17283378)
CM - Cites: Exp Clin Psychopharmacol. 2017 Apr;25(2):64-73 (medline /28287789)
CM - Cites: Am J Prev Med. 2005 Nov;29(4):353-65 (medline /16242602)
CM - Cites: Environ Res. 2017 Apr;154:261-268 (medline /28110240)
CM - Cites: Neurotoxicology. 2012 Oct;33(5):1338-45 (medline /22960421)
CM - Cites: Biomed Res Int. 2015;2015:159015 (medline /26114099)
CM - Cites: Lancet. 1986 May 10;1(8489):1077-81 (medline /2871345)
CM - Cites: Neurotoxicology. 2014 Sep;44:169-83 (medline /25010656)
CM - Cites: Toxicol Appl Pharmacol. 1998 May;150(1):174-85 (medline /9630467)
CM - Cites: Pharmacol Biochem Behav. 2009 Dec;94(2):271-7 (medline /19751756)
CM - Cites: Neurotoxicology. 1993 Summer-Fall;14(2-3):329-46 (medline /8247407)
CM - Cites: Neurotoxicology. 1997;18(3):673-88 (medline /9339816)
CM - Cites: Chemosphere. 2017 Sep;182:745-752 (medline /28535482)
CM - Cites: Cell Biol Toxicol. 2004 May;20(3):171-82 (medline /15250541)
CM - Cites: Behav Brain Res. 2000 Jan;107(1-2):45-58 (medline /10628729)
CM - Cites: N Engl J Med. 2003 Apr 17;348(16):1517-26 (medline /12700371)
CM - Cites: Adv Exp Med Biol. 2017;975:255-269 (medline /28849461)
CM - Cites: Biol Sex Differ. 2017 Aug 15;8(1):27 (medline /28810930)
CM - Cites: Am J Public Health. 2016 Feb;106(2):283-90 (medline /26691115)
CM - Cites: Toxicol Appl Pharmacol. 2007 Nov 15;225(1):1-27 (medline /17904601)
CM - Cites: Curr Environ Health Rep. 2014 Mar 21;1:132-147 (medline /24860722)
CM - Cites: Chem Res Toxicol. 2004 Aug;17(8):1064-76 (medline /15310238)
CM - Cites: Brain Res. 2000 Dec 15;886(1-2):172-189 (medline /11119695)
CM - Cites: Cell Biol Toxicol. 2001;17(3):169-77 (medline /11693578)
CM - Cites: Reprod Toxicol. 2017 Oct;73:184-195 (medline /28793237)
CM - Cites: Toxicol Appl Pharmacol. 2001 Apr 1;172(1):1-10 (medline /11264017)
CM - Cites: Neurotoxicol Teratol. 2015 Jan-Feb;47:66-79 (medline /25459689)
CM - Cites: Toxicol Sci. 2005 Oct;87(2):469-82 (medline /16049266)
CM - Cites: Eur J Clin Invest. 2017 Mar;47(3):262-269 (medline /28074555)
CM - Cites: Cereb Cortex. 2015 Sep;25(9):3132-43 (medline /24860018)
CM - Cites: Behav Brain Res. 2009 Dec 14;205(1):76-87 (medline /19631235)
CM - Cites: Front Mol Neurosci. 2017 Sep 07;10 :286 (medline /28936164)
CM - Cites: J Korean Med Sci. 2017 Jul;32(7):1097-1104 (medline /28581265)
CM - Cites: Am J Hum Biol. 2014 Nov-Dec;26(6):723-30 (medline /24599586)
CM - Cites: Brain Res. 1997 Aug 1;764(1-2):253-6 (medline /9295219)
CM - Cites: Toxicol Sci. 2013 Jan;131(1):194-205 (medline /22930682)
CM - Cites: Prog Neurobiol. 2017 Sep;156:164-188 (medline /28576664)
CM - Cites: Metab Brain Dis. 2013 Mar;28(1):85-92 (medline /23315312)
CM - Cites: Neurotoxicol Teratol. 1996 Sep-Oct;18(5):565-75 (medline /8888021)
CM - Cites: J Neuroendocrinol. 2009 Mar;21(4):415-20 (medline /19187468)
CM - Cites: Carcinogenesis. 2000 Nov;21(11):2097-104 (medline /11062174)
CM - Cites: Behav Brain Res. 1999 Jul;102(1-2):181-94 (medline /10403026)
CM - Cites: Neurotoxicology. 2012 Dec;33(6):1410-9 (medline /22659293)
CM - Cites: Mol Pharmacol. 1996 Apr;49(4):612-20 (medline /8609888)
CM - Cites: Neurosci Biobehav Rev. 2005;29(8):1193-205 (medline /16084592)
CM - Cites: Toxicol Ind Health. 1997 Jan-Feb;13(1):57-66 (medline /9098950)
CM - Cites: Endocrinology. 2015 Oct;156(10):3416-21 (medline /26241070)
CM - Cites: Environ Health Perspect. 2016 Jul;124(7):1114-20 (medline
/26713676)
CM - Cites: Transl Psychiatry. 2015 Mar 10;5:e522 (medline /25756805)
CM - Cites: Child Neuropsychol. 2014;20(5):527-38 (medline /23971942)
CM - Cites: Neurosci Biobehav Rev. 2005 Feb;29(1):3-38 (medline /15652252)
CM - Cites: Neurotoxicology. 2008 Sep;29(5):812-27 (medline /18440644)
CM - Cites: J Biol Chem. 2015 Jul 24;290(30):18361-9 (medline /26063799)
CM - Cites: Biol Trace Elem Res. 2017 Jun;177(2):288-296 (medline /27787814)
CM - Cites: Nat Rev Neurosci. 2013 Feb;14(2):97-111 (medline /23324667)
CM - Cites: JAMA. 2009 Jun 3;301(21):2252-9 (medline /19491187)
CM - Cites: Neurotoxicol Teratol. 2012 Jan-Feb;34(1):143-51 (medline /21875665)
CM - Cites: Environ Health Perspect. 2004 Sep;112(13):1329-33 (medline
/15345348)
CM - Cites: Neurotoxicology. 2016 May;54:22-33 (medline /26943976)
CM - Cites: Environ Health Perspect. 1998 Jun;106 Suppl 3:841-7 (medline
/9646047)
CM - Cites: Neurotoxicology. 2017 Sep;62:207-217 (medline /28712943)
CM - Cites: Environ Health Perspect. 2002 Oct;110 Suppl 5:689-94 (medline
/12426113)
CM - Cites: Chem Res Toxicol. 2017 Oct 16;30(10 ):1911-1920 (medline /28927277)
CM - Cites: Epigenetics. 2017 Aug;12 (8):607-615 (medline /28548590)
CM - Cites: Neurotoxicology. 2017 Mar;59:140-154 (medline /26721665)
CM - Cites: Pharmacol Biochem Behav. 1997 May-Jun;57(1-2):271-9 (medline
/9164582)
CM - Cites: Toxicol Lett. 2000 Mar 15;112-113:227-31 (medline /10720735)
CM - Cites: J Cell Physiol. 2018 Mar;233(3):1975-1984 (medline /28158904)
CM - Cites: Met Ions Life Sci. 2011;8:305-17 (medline /21473385)
CM - Cites: Brain Sci. 2016 Dec 30;7(1):null (medline /28042822)
CM - Cites: Neurotoxicology. 2014 Dec;45:121-30 (medline /25454719)
CM - Cites: Chronic Stress (Thousand Oaks). 2017 Jan-Dec;1:null (medline
/28856337)
CM - Cites: Mol Neurobiol. 2018 Jan;55(1):445-461 (medline /27966075)
CM - Cites: J Toxicol Environ Health B Crit Rev. 2009 Mar;12(3):206-23 (medline
/19466673)
CM - Cites: JAAPA. 2017 Feb;30(2):43-46 (medline /28072613)
DOCNO- medline/29355495

336 - TOXLINE
TI - Comparative effects of cadmium, zinc, arsenic and chromium on
olfactory-mediated neurobehavior and gene expression in larval zebrafish
(Danio rerio).
AU - Heffern K
AD - Department of Environmental and Occupational Health Sciences, University of
Washington, Seattle, WA 98105-6099, United States.
AU - Tierney K
AD - Department of Biological Sciences, University of Alberta, Edmonton, AB T6G
2R3, Canada.
AU - Gallagher EP
AD - Department of Environmental and Occupational Health Sciences, University of
Washington, Seattle, WA 98105-6099, United States. Electronic address:
evang3@uw.edu.
SO - Aquat Toxicol. 2018, May 28; 201:83-90. [Aquatic toxicology (Amsterdam,
Netherlands)]
AB - Studies have shown that olfactory-mediated behaviors that are critical to
survival can be disrupted by exposure to certain metals. Polluted
waterways often contain elevated levels of metals, yet only a subset have
been characterized for their potential to cause olfactory toxicity. A
larval zebrafish behavioral assay was developed to characterize
concentration-response curves for zinc (Zn), hexavalent chromium (Cr), and
arsenate (As) olfaction inhibition. Cadmium (Cd), an established olfactory
toxicant, was used as a positive control. As expected, following a 24-hour
exposure to Cd, we observed a reduced response to taurocholic acid (TCA),
a substrate for ciliated olfactory sensory neurons (OSNs), thus validating
the behavioral assay. Zn exposure similarly decreased the olfactory
response toward TCA, (IC50: 36&#8239;&mu;g/L and 76&#8239;&mu;g/L, for Cd
and Zn, respectively). The response towards a secondary odorant L-cysteine
(Cys), a substrate for ciliated and microvillous OSNs, was significantly
altered by both Cd and Zn exposure, although the response to Cys was not
completely removed in Zn treated larvae, suggesting preferential toxicity
towards ciliated OSNs. No significant changes in olfactory responses were
observed following Cr and As exposures. Exposures to binary mixtures of Cd
and Zn indicated that Zn had a protective effect against Cd toxicity at
low Zn concentrations. QuantiGene (QDP) RNA analysis revealed Cd to be a
potent inducer of metallothionein 2 (mt2) mRNA in zebrafish larvae, and Zn
to be a weak mt2 inducer, suggesting a protective role of mt2 in Cd and Zn
olfactory injury. By contrast, QDP analysis of eight other genes important
in mitigating the effects of oxidative stress suggested an antioxidant
response to Cd, but not Zn, As, and Cr suggesting that oxidative stress
was not a primary mechanism of Zn-induced olfactory dysfunction. In
summary, our study indicates that Zn inhibits zebrafish olfaction at
environmental concentrations and may potentially mitigate Cd induced
olfactory dysfunction when present in mixtures. The zebrafish behavioral
trough assay incorporating the odorants L-cysteine and TCA is an effective
assay to assess the effects of metals on olfactory function.
KW - Antioxidant gene expression
KW - Metallothionein
KW - Metals
KW - Olfaction
KW - Olfactory sensory neurons
KW - Zebrafish
LA - eng
IS - 1879-1514 (Electronic)
PT - Journal Article
TA - Aquat Toxicol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Aquatic toxicology (Amsterdam, Netherlands)
EDAT- 20180528
STAT- Publisher
DOCNO- medline/29890505

337 - TOXLINE
TI - Melarsoprol Resistance in African Trypanosomiasis.
AU - Fairlamb AH
AD - The Wellcome Trust Centre for Anti-Infectives Research, School of Life
Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK; ORCID:
http://orcid.org/0000-0001-5134-0329.
AU - Horn D
AD - The Wellcome Trust Centre for Anti-Infectives Research, School of Life
Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK; ORCID:
http://orcid.org/0000-0001-5173-9284. Electronic address: d.horn@dundee.ac.uk.
SO - Trends Parasitol. 2018, Jun; 34(6):481-492. [Trends in parasitology]
AB - Arsenicals were introduced as monotherapies for the treatment of human
African trypanosomiasis, or sleeping sickness, over 100 years ago.
Toxicity has always been an issue but these drugs have proven to be both
effective and quite durable. Unfortunately, melarsoprol-resistant
parasites emerged as early as the 1970s and were widespread by the late
1990s. Resistance was due to mutations affecting an aquaglyceroporin
(AQP2), a parasite solute and drug transporter. This is the only example
of widespread drug resistance in trypanosomiasis patients for which the
genetic basis is known. This link between melarsoprol and AQP2 illustrates
how a drug transporter can improve drug selectivity but, at the same time,
highlights the risk of resistance when the drug uptake mechanism is
dispensable for parasite viability and virulence.
KW - AQP2
KW - AT1
KW - Trypanosoma brucei
KW - adenosine transporter
KW - aquaglyceroporin
KW - arsenic
KW - pentamidine
LA - eng
IS - 1471-5007 (Electronic)
PT - Journal Article
PT - Review
TA - Trends Parasitol
YR - 2018
DATE- 20180527
CI - Copyright &copy; 2018 The Authors. Published by Elsevier Ltd.. All rights
reserved.
CITO- NLM
CS - England
FJT - Trends in parasitology
EDAT- 20180425
STAT- In-Data-Review
DOCNO- medline/29705579

338 - TOXLINE
TI - Stabilization of arsenic and lead by magnesium oxide (MgO) in different
seawater concentrations.
AU - Kameda K
AD - Department of Bioapplications and Systems Engineering, Tokyo University of
Agriculture and Technology, Japan; Obayashi Corporation, Japan.
AU - Hashimoto Y
AD - Department of Bioapplications and Systems Engineering, Tokyo University of
Agriculture and Technology, Japan. Electronic address: yhashim@cc.tuat.ac.jp.
AU - Ok YS
AD - Korea Biochar Research Center, O-Jeong Eco-Resilience Institute (OJERI) &amp;
Division of Environmental Science and Ecological Engineering, Korea University,
Republic of Korea.
SO - Environ Pollut. 2018, Feb; 233:952-959. [Environmental pollution (Barking,
Essex : 1987)]
AB - Ongoing sea level rise will have a major impact on mobility and migration
of contaminants by changing a number of natural phenomena that alter
geochemistry and hydrology of subsurface environment. In-situ
immobilization techniques may be a promising remediation strategy for
mitigating contaminant mobility induced by sea level rise. This study
investigated the reaction mechanisms of magnesium oxide (MgO) with aqueous
Pb and As under freshwater and seawater using XAFS spectroscopy. Initial
concentrations of Pb and As in freshwater strongly controlled the
characteristics of the reaction product of MgO. Our study revealed that i)
the removal of aqueous Pb and As by MgO was increased by the elevation of
seawater concentration, and ii) the removal of As was attributed primarily
to (inner-sphere) surface adsorption on MgO, independent on seawater
concentrations, and iii) the retention mechanism of Pb was dependent on
seawater concentrations where formations of Pb oxides and adsorption on
the MgO surface were predominant in solutions with low and high salinity,
respectively. The release of As fixed with MgO significantly increased in
seawater compared to freshwater, although the amount of As desorbed
accounted for < 0.2% of total As.
KW - Heavy metals
KW - Periclase
KW - Sea level rise
KW - Soil pollution
KW - XAFS
RN - 059QF0KO0R
RN - 2P299V784P
RN - 3A3U0GI71G
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180418
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171106
STAT- MEDLINE
DOCNO- medline/29122367

339 - TOXLINE
TI - Individual susceptibility to arsenic-induced diseases: the role of host
genetics, nutritional status, and the gut microbiome.
AU - Chi L
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
AU - Gao B
AD - NIH West Coast Metabolomics Center, University of California, Davis, CA,
95616, USA.
AU - Tu P
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
AU - Liu CW
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
AU - Xue J
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
AU - Lai Y
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
AU - Ru H
AD - Department of Population Health and Pathobiology, North Carolina State
University, Raleigh, NC, 27607, USA.
AU - Lu K
AD - Department of Environmental Sciences and Engineering, University of North
Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. kunlu@unc.edu.
SO - Mamm Genome. 2018, Feb; 29(1-2):63-79. [Mammalian genome : official
journal of the International Mammalian Genome Society]
AB - Arsenic (As) contamination in water or food is a global issue affecting
hundreds of millions of people. Although As is classified as a group 1
carcinogen and is associated with multiple diseases, the individual
susceptibility to As-related diseases is highly variable, such that a
proportion of people exposed to As have higher risks of developing related
disorders. Many factors have been found to be associated with As
susceptibility. One of the main sources of the variability found in As
susceptibility is the variation in the host genome, namely, polymorphisms
of many genes involved in As transportation, biotransformation, oxidative
stress response, and DNA repair affect the susceptibility of an individual
to As toxicity and then influence the disease outcomes. In addition,
lifestyles and many nutritional factors, such as folate, vitamin C, and
fruit, have been found to be associated with individual susceptibility to
As-related diseases. Recently, the interactions between As exposure and
the gut microbiome have been of particular concern. As exposure has been
shown to perturb gut microbiome composition, and the gut microbiota has
been shown to also influence As metabolism, which raises the question of
whether the highly diverse gut microbiota contributes to As
susceptibility. Here, we review the literature and summarize the factors,
such as host genetics and nutritional status, that influence As
susceptibility, and we also present potential mechanisms of how the gut
microbiome may influence As metabolism and its toxic effects on the host
to induce variations in As susceptibility. Challenges and future
directions are also discussed to emphasize the importance of
characterizing the specific role of these factors in interindividual
susceptibility to As-related diseases.
LA - eng
IS - 1432-1777 (Electronic)
PT - Journal Article
PT - Review
TA - Mamm Genome
YR - 2018
DATE- 20180615
CITO- NLM
CS - United States
FJT - Mammalian genome : official journal of the International Mammalian Genome
Society
EDAT- 20180210
STAT- In-Data-Review
CM - Cites: J Biomed Sci. 2010 Aug 26;17 :70 (medline /20796278)
CM - Cites: Pharmacol Ther. 1990;46(1):67-93 (medline /2181492)
CM - Cites: Food Chem Toxicol. 2010 Apr;48(4):1032-9 (medline /20096321)
CM - Cites: Chem Res Toxicol. 2007 Aug;20(8):1120-5 (medline /17630711)
CM - Cites: Int J Cancer. 2006 May 15;118(10):2470-8 (medline /16353154)
CM - Cites: Mutat Res. 2011 Jan 10;706(1-2):7-12 (medline /21035470)
CM - Cites: Chem Res Toxicol. 2014 Apr 21;27(4):457-61 (medline /24517124)
CM - Cites: Science. 2013 Mar 1;339(6123):1084-8 (medline /23328391)
CM - Cites: Toxicol Sci. 2011 May;121(1):132-9 (medline /21357384)
CM - Cites: Science. 2012 Jun 8;336(6086):1262-7 (medline /22674330)
CM - Cites: Eur J Biochem. 2000 Apr;267(7):2008-13 (medline /10727940)
CM - Cites: Environ Health Perspect. 2004 Jul;112(10):1104-9 (medline
/15238285)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):345-53 (medline
/15276414)
CM - Cites: Epidemiology. 2006 Jul;17(4):459-67 (medline /16755266)
CM - Cites: Toxicol Appl Pharmacol. 2014 Feb 15;275(1):22-7 (medline /24384392)
CM - Cites: Chem Res Toxicol. 2002 May;15(5):692-8 (medline /12018991)
CM - Cites: Toxicol Appl Pharmacol. 2009 Mar 15;235(3):338-50 (medline
/19168087)
CM - Cites: Mol Cell Biol. 1990 Dec;10(12):6160-71 (medline /2247054)
CM - Cites: Nature. 2014 Oct 9;514(7521):181-6 (medline /25231862)
CM - Cites: Biomed Res Int. 2015;2015:892579 (medline /26295053)
CM - Cites: Food Chem Toxicol. 2014 Apr;66:262-77 (medline /24508525)
CM - Cites: J Environ Sci (China). 2016 Nov;49:38-58 (medline /28007179)
CM - Cites: Toxicol Lett. 2002 Jul 7;133(1):1-16 (medline /12076506)
CM - Cites: Carcinogenesis. 2007 Mar;28(3):672-6 (medline /17050553)
CM - Cites: Cancer Lett. 2003 Nov 10;201(1):57-65 (medline /14580687)
CM - Cites: Chem Res Toxicol. 2014 Feb 17;27(2):172-4 (medline /24490651)
CM - Cites: Exp Biol Med (Maywood). 2008 Mar;233(3):377-84 (medline /18296743)
CM - Cites: Mutat Res. 2008 Jan 1;637(1-2):80-92 (medline /17850829)
CM - Cites: Environ Health Perspect. 2007 Apr;115(4):599-605 (medline
/17450230)
CM - Cites: Clin Chem Lab Med. 2005;43(10):1069-75 (medline /16197300)
CM - Cites: Chemosphere. 2017 Oct;184:460-466 (medline /28618278)
CM - Cites: Chem Res Toxicol. 2001 Jun;14(6):651-6 (medline /11409934)
CM - Cites: Toxicol Sci. 2017 Dec 1;160(2):193-204 (medline /28973555)
CM - Cites: Vitam Horm. 2008;79:1-44 (medline /18804690)
CM - Cites: Toxicol Appl Pharmacol. 2010 Sep 1;247(2):138-45 (medline
/20600216)
CM - Cites: Nature. 2006 Dec 21;444(7122):1027-31 (medline /17183312)
CM - Cites: Curr Opin Biotechnol. 2013 Apr;24(2):160-8 (medline /22940212)
CM - Cites: Toxicol Appl Pharmacol. 2011 Dec 15;257(3):349-55 (medline
/21982800)
CM - Cites: Nature. 2012 Jun 13;486(7402):207-14 (medline /22699609)
CM - Cites: Environ Health Perspect. 2008 Apr;116(4):501-5 (medline /18414634)
CM - Cites: Chemosphere. 2012 Jul;88(4):432-8 (medline /22440634)
CM - Cites: Toxicol Lett. 1987 Jun;37(1):41-6 (medline /3590229)
CM - Cites: J Environ Pathol Toxicol Oncol. 2010;29(2):91-100 (medline
/20932244)
CM - Cites: Annu Rev Nutr. 2000;20:153-67 (medline /10940330)
CM - Cites: Nature. 2012 May 09;486(7402):222-7 (medline /22699611)
CM - Cites: J Agric Food Chem. 2016 Feb 3;64(4):923-31 (medline /26766512)
CM - Cites: Arch Toxicol. 2000 Aug;74(6):289-99 (medline /11005674)
CM - Cites: Pharmacogenet Genomics. 2006 Dec;16(12):863-71 (medline /17108810)
CM - Cites: Science. 2006 Jun 2;312(5778):1355-9 (medline /16741115)
CM - Cites: Environ Geochem Health. 2016 Apr;38(2):339-51 (medline /26169729)
CM - Cites: Toxicol Appl Pharmacol. 2011 Oct 15;256(2):174-8 (medline
/21864556)
CM - Cites: Toxicol Appl Pharmacol. 2013 Oct 1;272(1):30-6 (medline /23727622)
CM - Cites: N Engl J Med. 1981 Oct 1;305(14):789-94 (medline /7266632)
CM - Cites: PLoS One. 2015 Sep 14;10 (9):e0137810 (medline /26368803)
CM - Cites: Antioxid Redox Signal. 2005 May-Jun;7(5-6):813-22 (medline
/15890029)
CM - Cites: Atherosclerosis. 1998 Dec;141(2):249-57 (medline /9862173)
CM - Cites: FEBS Lett. 2014 Nov 17;588(22):4244-9 (medline /24873878)
CM - Cites: J Toxicol Environ Health A. 2005 Sep;68(17-18):1471-84 (medline
/16076760)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1270-8 (medline
/17548696)
CM - Cites: PLoS One. 2012;7(4):e36095 (medline /22553482)
CM - Cites: Nutrients. 2011 Jan;3(1):118-34 (medline /22254078)
CM - Cites: Environ Health Perspect. 2006 Mar;114(3):334-40 (medline /16507454)
CM - Cites: Mutat Res Genet Toxicol Environ Mutagen. 2014 Jan 1;759:51-5
(medline /24361376)
CM - Cites: J Toxicol Environ Health A. 2007 Jan 15;70(2):159-70 (medline
/17365577)
CM - Cites: Toxicol Appl Pharmacol. 2012 Oct 1;264(1):121-30 (medline
/22868225)
CM - Cites: Mol Pharmacol. 2014 Aug;86(2):168-79 (medline /24870404)
CM - Cites: Microbiol Insights. 2014 Nov 11;7:25-34 (medline /25452698)
CM - Cites: Toxicol Lett. 2002 Nov 15;136(1):65-76 (medline /12368058)
CM - Cites: Pharmacogenomics. 2008 Aug;9(8):1113-32 (medline /18681785)
CM - Cites: Nat Commun. 2014;5:3114 (medline /24445449)
CM - Cites: Nat Rev Microbiol. 2016 Apr;14 (5):273-87 (medline /26972811)
CM - Cites: Toxicol Sci. 2009 Aug;110(2):282-92 (medline /19478237)
CM - Cites: Toxicol Appl Pharmacol. 2010 Aug 15;247(1):36-40 (medline
/20510259)
CM - Cites: Sci Total Environ. 2011 Jan 1;409(3):465-70 (medline /21094982)
CM - Cites: Mutat Res. 2016 Oct;809:50-56 (medline /27692299)
CM - Cites: Biochem Biophys Res Commun. 2003 Feb 7;301(2):516-20 (medline
/12565892)
CM - Cites: Biochem Pharmacol. 2016 Nov 15;120:72-82 (medline /27659809)
CM - Cites: Atherosclerosis. 2007 Jun;192(2):305-12 (medline /16973168)
CM - Cites: J Bacteriol. 1992 Aug;174(16):5340-5 (medline /1322884)
CM - Cites: Environ Health. 2013 Sep 02;12(1):73 (medline /24004508)
CM - Cites: Lancet. 2003 Feb 8;361(9356):512-9 (medline /12583961)
CM - Cites: Chem Res Toxicol. 2006 Aug;19(8):1010-8 (medline /16918239)
CM - Cites: J Trace Elem Med Biol. 2011 Dec;25(4):247-53 (medline /21924885)
CM - Cites: Environ Res. 2014 Jul;132:156-67 (medline /24792412)
CM - Cites: Am J Clin Nutr. 2007 Oct;86(4):1202-9 (medline /17921403)
CM - Cites: J Nutr Biochem. 2006 May;17(5):319-27 (medline /16214333)
CM - Cites: Annu Rev Genomics Hum Genet. 2012;13:151-70 (medline /22703178)
CM - Cites: Environ Sci Technol. 2015 Sep 1;49(17):10675-81 (medline /26248026)
CM - Cites: Environ Health Perspect. 2008 Mar;116(3):315-21 (medline /18335097)
CM - Cites: Environ Health. 2007 Feb 06;6:5 (medline /17284320)
CM - Cites: Toxicol Appl Pharmacol. 2005 Aug 7;206(2):198-206 (medline
/15967209)
CM - Cites: Toxicol Appl Pharmacol. 2010 Feb 1;242(3):352-62 (medline
/19914269)
CM - Cites: Science. 2001 Feb 16;291(5507):1284-9 (medline /11181991)
CM - Cites: JAMA. 2004 Dec 22;292(24):2984-90 (medline /15613666)
CM - Cites: Mutat Res. 2006 Oct 10;601(1-2):102-12 (medline /16930632)
CM - Cites: Am J Clin Nutr. 2015 Jun;101(6):1286-94 (medline /25788000)
CM - Cites: Environ Health Perspect. 2014 Aug;122(8):817-22 (medline /24833621)
CM - Cites: Environ Mol Mutagen. 2015 Dec;56(9):759-66 (medline /26031227)
CM - Cites: Science. 2017 Jun 23;356(6344): (medline /28642381)
CM - Cites: Environ Toxicol Pharmacol. 2016 Apr;43:68-73 (medline /26970057)
CM - Cites: Toxicol Appl Pharmacol. 2014 Sep 15;279(3):373-9 (medline
/25018058)
CM - Cites: Environ Int. 2014 Aug;69:148-58 (medline /24853282)
CM - Cites: J Appl Toxicol. 1981 Oct;1(5):278-83 (medline /7185888)
CM - Cites: Science. 2005 Jun 10;308(5728):1635-8 (medline /15831718)
CM - Cites: Int J Environ Res Public Health. 2013 Apr 12;10(4):1527-46 (medline
/23583964)
CM - Cites: Arch Toxicol. 2010 Jan;84(1):17-24 (medline /19834688)
CM - Cites: Toxicol Sci. 2002 Nov;70(1):13-9 (medline /12388830)
CM - Cites: Toxicol Appl Pharmacol. 2006 Nov 1;216(3):446-57 (medline
/16930657)
CM - Cites: Carcinogenesis. 2007 Jul;28(7):1520-5 (medline /17374727)
CM - Cites: Teratology. 1991 Aug;44(2):209-14 (medline /1925980)
CM - Cites: Science. 2005 Mar 25;307(5717):1915-20 (medline /15790844)
CM - Cites: Ecotoxicol Environ Saf. 2013 Jun;92:119-22 (medline /23537727)
CM - Cites: Environ Health Perspect. 2005 Jun;113(6):775-81 (medline /15929903)
CM - Cites: Environ Sci Technol. 2016 Jul 5;50(13):7189-97 (medline /27280682)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 1997 Aug;6(8):589-96 (medline
/9264271)
CM - Cites: Toxicol Appl Pharmacol. 2004 Aug 1;198(3):458-67 (medline
/15276427)
CM - Cites: Chem Res Toxicol. 2014 Nov 17;27(11):1979-89 (medline /25325836)
CM - Cites: Environ Health. 2012 Jun 29;11:43 (medline /22747749)
CM - Cites: Toxicol Sci. 2010 Oct;117(2):249-52 (medline /20660472)
CM - Cites: Chem Res Toxicol. 2013 Dec 16;26(12):1893-903 (medline /24134150)
CM - Cites: Environ Sci Technol. 2007 Aug 1;41(15):5542-7 (medline /17822130)
CM - Cites: Atherosclerosis. 2011 Dec;219(2):704-8 (medline /21945498)
CM - Cites: Environ Sci Pollut Res Int. 2017 Apr;24(11):10621-10629 (medline
/28283972)
CM - Cites: Asian Pac J Cancer Prev. 2003 Jul-Sep;4(3):233-7 (medline
/14507244)
CM - Cites: Mol Cell Biochem. 2005 Nov;279(1-2):105-12 (medline /16283519)
CM - Cites: Environ Health Perspect. 2005 Dec;113(12):1683-8 (medline
/16330347)
CM - Cites: Environ Health Perspect. 2007 Jul;115(7):1081-6 (medline /17637926)
CM - Cites: Arch Toxicol. 2007 Aug;81(8):545-51 (medline /17318627)
CM - Cites: Carcinogenesis. 2007 Aug;28(8):1697-702 (medline /17470448)
CM - Cites: Eur J Cancer Prev. 1997 Mar;6 Suppl 1:S43-5 (medline /9167138)
CM - Cites: Cent Nerv Syst Agents Med Chem. 2017;17 (3):187-195 (medline
/28155600)
CM - Cites: Hum Exp Toxicol. 2002 Dec;21(12):675-80 (medline /12540038)
CM - Cites: Environ Health Perspect. 2013 Mar;121(3):295-302 (medline
/23458756)
CM - Cites: Mutat Res. 1997 Jun;386(3):197-207 (medline /9219558)
CM - Cites: J Proteome Res. 2010 Oct 1;9(10):5284-95 (medline /20806900)
CM - Cites: Am J Respir Cell Mol Biol. 1996 Jul;15(1):9-19 (medline /8679227)
CM - Cites: Environ Health Perspect. 2014 Mar;122(3):284-91 (medline /24413286)
CM - Cites: Environ Res. 2010 Aug;110(6):580-7 (medline /20670920)
CM - Cites: Chem Res Toxicol. 2011 Apr 18;24(4):475-7 (medline /21388151)
CM - Cites: Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30 (medline
/17064664)
CM - Cites: Nature. 2013 Jan 3;493(7430):45-50 (medline /23222524)
CM - Cites: Environ Res. 2011 Aug;111(6):804-10 (medline /21605854)
CM - Cites: Free Radic Res. 2004 Oct;38(10):1037-54 (medline /15512792)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009
Apr;27(2):120-39 (medline /19412858)
CM - Cites: Science. 2016 Apr 29;352(6285):560-4 (medline /27126039)
CM - Cites: Arch Toxicol. 2012 Jun;86(6):869-78 (medline /22193621)
CM - Cites: Environ Health Perspect. 2009 May;117(5):825-31 (medline /19479028)
CM - Cites: Am J Epidemiol. 1991 Sep 15;134(6):545-51 (medline /1951260)
CM - Cites: Environ Health Perspect. 2010 Jul;118(7):1004-9 (medline /20603239)
CM - Cites: Mutat Res. 2013 Jul 4;755(1):1-5 (medline /23644288)
CM - Cites: Biochem Biophys Res Commun. 2004 Apr 16;316(4):1178-85 (medline
/15044109)
CM - Cites: Chem Res Toxicol. 2016 Jun 20;29(6):949-51 (medline /27268458)
DOCNO- medline/29429126

340 - TOXLINE
TI - Retention of arsenic, chromium and boron on an outcropping clay-rich rock
formation (the T�gulines Clay, eastern France).
AU - Debure M
AD - BRGM, French Geological Survey, 45060 Orl�ans, France. Electronic address:
m.debure@brgm.fr.
AU - Tournassat C
AD - BRGM, French Geological Survey, 45060 Orl�ans, France; UMR 7327 Institut des
Sciences de la Terre d'Orl�ans (ISTO), Universit� d'Orl�ans-CNRS/INSU-BRGM,
Orl�ans, France; Energy Geoscience Division, Lawrence Berkeley National Laboratory,
1 Cyclotron Rd., Berkeley, CA 94720, USA.
AU - Lerouge C
AD - BRGM, French Geological Survey, 45060 Orl�ans, France.
AU - Mad� B
AD - Andra, R&amp;D Division, Transfer Migration Group, 92298 Ch�tenay-Malabry,
France.
AU - Robinet JC
AD - Andra, R&amp;D Division, Transfer Migration Group, 92298 Ch�tenay-Malabry,
France.
AU - Fern�ndez AM
AD - CIEMAT, Dpto. Medio Ambiente, Avda./Complutense 40, 28040 Madrid, Spain.
AU - Grangeon S
AD - BRGM, French Geological Survey, 45060 Orl�ans, France.
SO - Sci Total Environ. 2018, Jun 11; 642:216-229. [The Science of the total
environment]
AB - The retention behavior of three toxic chemicals, As, Cr and B, was
investigated for an outcropping rock formation, the Albian
T�gulines Clay (France, Aube). At a shallow depth, T�gulines
Clay is affected by weathering processes leading to contrasted geochemical
conditions with depth. One of the main features of the weathering is the
occurrence of a redox transition zone near the surface. Batch sorption
experiments of As(V), As(III), Cr(VI) and B were performed on samples
collected at two depths representative either of oxidized or reduced
mineral assemblages. Batch sorption experiments highlighted a distinct
behavior between As, Cr and B oxyanions. Cr(VI) retention behavior was
dominated by redox phenomena, notably its reduction to Cr(III). The
in-situ redox state of the T�gulines Clay samples has a significant
effect on Cr retention. On the contrary, As(V) reduction into As(III) is
moderate and its retention slightly affected by the in-situ redox state of
the T�gulines Clay. As(V) retention is higher than As(III)
retention in agreement with literature data. B retention is strongly
related to its natural abundance in the T�gulines clay samples.
Distribution coefficient of B corrected from its natural content is
expected to be very low for in-situ conditions. Finally, the retention and
mobility of these oxyanions were affected by clay mineralogy, natural
abundance, and reducing capacity of the Tegulines Clay.
KW - Arsenic
KW - Boron
KW - Chromium
KW - Oxyanions retention
KW - Redox environment
KW - Tégulines Clay
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180611
STAT- Publisher
DOCNO- medline/29902620

341 - TOXLINE
TI - Trace Metal Levels in Rainbow Trout (Oncorhynchus mykiss) Cultured in Net
Cages in a Reservoir and Evaluation of Human Health Risks from
Consumption.
AU - Varol M
AD - Faculty of Fisheries, Department of Basic Aquatic Sciences, Inonu University,
Malatya, Turkey. memet.varol@inonu.edu.tr.
AU - Kaya GK
AD - Faculty of Fisheries, Department of Fish Processing Technology, Munzur
University, Tunceli, Turkey.
AU - Alp SA
AD - Faculty of Fisheries, Department of Fish Processing Technology, Munzur
University, Tunceli, Turkey.
AU - S�nb�l MR
AD - Aquaculture Research Institute, Elaz&#305;&#287;, Turkey.
SO - Biol Trace Elem Res. 2018, Jul; 184(1):268-278. [Biological trace element
research]
AB - Although fish consumption has positive health effects, metals accumulated
in fish can cause human health risks. In this study, the levels of ten
metals in rainbow trout (Oncorhynchus mykiss) farmed in the Keban Dam
Reservoir, which has the biggest rainbow trout production capacity in
Turkey, were determined and compared with the maximum permissible levels
(MPLs). Also, human health risks associated with rainbow trout consumption
were assessed. The metal concentrations in rainbow trout were found below
the MPLs. The estimated daily intake of each metal was much lower than the
respective tolerable daily intake. The target hazard quotient (THQ) for
individual metal and total THQ for combined metals did not exceed 1,
indicating no health risk for consumers. The cancer risk (CR) value for
inorganic arsenic was within the acceptable lifetime risk range of 10-6
and 10-4. For carcinogenic and non-carcinogenic effects, the maximum
allowable fish consumption rates were high enough to ensure the human
health. According to these results, the consumption of rainbow trout
farmed in the Keban Dam Reservoir does not pose a risk on human health.
KW - Bioconcentration factor
KW - Biomagnification factor
KW - Farmed rainbow trout
KW - Fish consumption advisories
KW - Metals
KW - Risk assessment
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180608
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170919
STAT- In-Process
DOCNO- medline/28929460

342 - TOXLINE
TI - Partitioning and potential mobilization of aluminum, arsenic, iron, and
heavy metals in tropical active and post-active acid sulfate soils:
Influence of long-term paddy rice cultivation.
AU - Sukitprapanon T
AD - Division of Soil Science and Environment, Department of Plant Science and
Natural Resources, Faculty of Agriculture, Khon Kaen University, Khon Kaen, 40002,
Thailand; Research Group of Soil Organic Matter Management and Problem Soils in
Northeast Thailand, Khon Kaen University, Khon Kaen, 40002, Thailand. Electronic
address: tanasuk@kku.ac.th.
AU - Suddhiprakarn A
AD - Department of Soil Science, Faculty of Agriculture, Kasetsart University,
Bangkok, 10900, Thailand.
AU - Kheoruenromne I
AD - Department of Soil Science, Faculty of Agriculture, Kasetsart University,
Bangkok, 10900, Thailand.
AU - Gilkes RJ
AD - School of Agriculture and Environment, The University of Western Australia,
35 Stirling Highway, Crawley, WA 6009, Australia.
SO - Chemosphere. 2018, Apr; 197:691-702. [Chemosphere]
AB - Drainage of potential acid sulfate soils (PASS) for paddy rice cultivation
results in the formation of active acid sulfate soils (AASS) and
subsequently post-active acid sulfate soils (PAASS). The drainage of PASS
causes severe environmental problems including acidification and metal
contamination of soil and water resources. This study examined the
vertical distribution and partitioning of Al, As, Co, Cu, Fe, Mn, Ni, Pb,
and Zn in six tropical acid sulfate soils representing AASS and PAASS
under long-term paddy rice cultivation ( > 145 years). The bulk soil
samples were analyzed for total concentrations of Al, As, Co, Cu, Fe, Mn,
Ni, Pb, and Zn. The partitioning of these elements was examined by a
sequential extraction procedure. Labile Al is higher in ASS which is
associated with low soil pH. During drainage, mobilization of As, Cu, and
Pb is limited by coprecipitation with (poorly) crystalline Fe oxides
minerals in the topsoil and partly oxidized layer of both soil types.
These elements are associated with iron (mono) sulfides in unoxidized
layer. When PASS are exposed to air, Co, Mn, Ni, and Zn are leached from
the soils and are dominantly associated with iron sulfides in the
unoxidized sediments. Labile Mn, Ni, and Zn are elevated in the unoxidized
layer of PAASS because these elements are leached from the partly oxidized
layers and adsorbed onto soil constituents. Cobalt is probably
precipitated or adsorbed onto (poorly) crystalline minerals.
KW - Long-term paddy rice cultivation
KW - Potentially toxic elements
KW - Sequential extraction
KW - Tropical active and post-active acid sulfate soils
RN - CPD4NFA903
RN - E1UOL152H7
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180525
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180203
STAT- MEDLINE
DOCNO- medline/29407833

343 - TOXLINE
TI - Arsenic hyperaccumulation in Pityrogramma calomelanos L. (Link): adaptive
traits to deal with high metalloid concentrations.
AU - Campos NV
AD - N�cleo em Ecologia e Desenvolvimento S�cio-Ambiental de Maca� (NUPEM),
Universidade Federal do Rio de Janeiro, Maca�, RJ, 27965-045, Brazil.
AU - Arcanjo-Silva S
AD - Departamento de Biologia Vegetal, Universidade Federal de Vi�osa, Avenida
Peter Henry Rolfs, s/n, Vi�osa, MG, 36570-900, Brazil.
AU - Freitas-Silva L
AD - Departamento de Biologia Vegetal, Universidade Federal de Vi�osa, Avenida
Peter Henry Rolfs, s/n, Vi�osa, MG, 36570-900, Brazil.
AU - de Ara�jo TO
AD - Departamento de Biologia Vegetal, Universidade Federal de Vi�osa, Avenida
Peter Henry Rolfs, s/n, Vi�osa, MG, 36570-900, Brazil.
AU - Souza-Fernandes DP
AD - Departamento de Biologia Vegetal, Universidade Federal de Vi�osa, Avenida
Peter Henry Rolfs, s/n, Vi�osa, MG, 36570-900, Brazil.
AU - Azevedo AA
AD - Departamento de Biologia Vegetal, Universidade Federal de Vi�osa, Avenida
Peter Henry Rolfs, s/n, Vi�osa, MG, 36570-900, Brazil. aazevedo@ufv.br.
SO - Environ Sci Pollut Res Int. 2018, Apr; 25(11):10720-10729. [Environmental
science and pollution research international]
AB - Pityrogramma calomelanos is interestingly the single non-Pteris arsenic
(As)-hyperaccumulating fern. It has been pointed as a potential species
for phytoremediation and a model plant to study the As toxicity and its
mechanisms of action. In order to investigate the morphoanatomical traits
associated to As tolerance, P. calomelanos plants were exposed to
different As concentrations in hydroponic solution. At low As dose
(1 mM As), 90% of the As accumulated in plants was allocated in
shoots, and no symptoms of As stress were observed in fronds and roots.
Under higher As exposure (10 and 30 mM As), 81-74% of the total As in
plants was present in shoots, and apical and marginal necroses on pinnae
were observed. Anatomical observations showed that As induces damages
mainly in the secondary veins and adjacent cells. High amounts of phenols
were observed in pinna tissues of control and treated plants. In the
roots, As promoted slight alterations as detachment of border-like cells
and accumulation of granular substances in cortical cells. The high
root-to-shoot As translocation and the constitutive presence of phenols
and border-like cells protecting the root tips showed to be adaptive
traits that allow P. calomelanos to survive in contaminated sites.
KW - Anatomic alterations
KW - Border-like cells
KW - Metalloid
KW - Phenols
KW - Tolerance
KW - Translocation
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180416
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180202
STAT- In-Process
CM - Cites: Int J Phytoremediation. 2012 Sep;14(8):786-95 (medline /22908644)
CM - Cites: J Zhejiang Univ Sci B. 2008 Mar;9(3):210-20 (medline /18357623)
CM - Cites: Plant Cell. 2010 Jun;22(6):2045-57 (medline /20530755)
CM - Cites: Plant Physiol. 2012 Jul;159(3):1149-58 (medline /22635118)
CM - Cites: Physiol Plant. 2016 Jun;157(2):135-46 (medline /26853807)
CM - Cites: Curr Opin Plant Biol. 2011 Oct;14(5):554-62 (medline /21820943)
CM - Cites: Environ Sci Technol. 2010 Jun 15;44(12):4735-40 (medline /20459123)
CM - Cites: Toxicol Pathol. 2003 Nov-Dec;31(6):575-88 (medline /14585726)
CM - Cites: New Phytol. 2016 Jan;209(2):762-72 (medline /26010225)
CM - Cites: New Phytol. 2009 Mar;181(4):777-94 (medline /19207683)
CM - Cites: J Plant Physiol. 2018 Jan;220:34-42 (medline /29145070)
CM - Cites: J Hazard Mater. 2012 Oct 15;235-236:271-8 (medline /22906843)
CM - Cites: Front Cell Dev Biol. 2017 Jul 18;5:67 (medline /28770198)
CM - Cites: New Phytol. 2016 Jan;209(2):746-61 (medline /26372374)
CM - Cites: Environ Sci Pollut Res Int. 2015 Aug;22(15):11265-74 (medline
/25797017)
CM - Cites: Sci Total Environ. 2002 Feb 4;284(1-3):27-35 (medline /11846172)
CM - Cites: Chemosphere. 2006 Feb;62(5):803-9 (medline /15972226)
CM - Cites: J Environ Sci (China). 2007;19(6):714-8 (medline /17969645)
CM - Cites: Planta. 2014 May;239(5):1055-64 (medline /24519545)
CM - Cites: Plant Physiol Biochem. 2015 Dec;97:28-35 (medline /26408808)
CM - Cites: J Prev Med Public Health. 2014 Sep;47(5):253-7 (medline /25284196)
CM - Cites: J Exp Bot. 2005 May;56(415):1335-42 (medline /15781440)
CM - Cites: Front Physiol. 2012 Jul 23;3:275 (medline /22934029)
CM - Cites: Nature. 2001 Feb 1;409(6820):579 (medline /11214308)
DOCNO- medline/29396820

344 - TOXLINE
TI - Monitoring of metallic contaminants in energy drinks using ICP-MS.
AU - Kilic S
AD - Food Safety and Agricultural Research Center, Akdeniz University, 07058,
Antalya, Turkey.
AU - Cengiz MF
AD - Food Safety and Agricultural Research Center, Akdeniz University, 07058,
Antalya, Turkey. fcengiz@akdeniz.edu.tr.
AU - Kilic M
AD - Food Safety and Agricultural Research Center, Akdeniz University, 07058,
Antalya, Turkey.
SO - Environ Monit Assess. 2018, Mar 09; 190(4):202. [Environmental monitoring
and assessment]
AB - In this study, an improved method was validated for the determination of
some metallic contaminants (arsenic (As), chromium (Cr), cadmium (Cd),
lead (Pb), iron (Fe), nickel (Ni), copper (Cu), Mn, and antimony (Sb)) in
energy drinks using inductive coupled plasma mass spectrometry (ICP-MS).
The validation procedure was applied for the evaluation of linearity,
repeatability, recovery, limit of detection, and quantification. In
addition, to verify the trueness of the method, it was participated in an
interlaboratory proficiency test for heavy metals in soft drink organized
by the LGC (Laboratory of the Government Chemist) Standard. Validated
method was used to monitor for the determination of metallic contaminants
in commercial energy drink samples. Concentrations of As, Cr, Cd, Pb, Fe,
Ni, Cu, Mn, and Sb in the samples were found in the ranges of 0.76-6.73,
13.25-100.96, 0.16-2.11, 9.33-28.96, 334.77-937.12, 35.98-303.97,
23.67-60.48, 5.45-489.93, and 0.01-0.42 &mu;g L-1, respectively.
The results were compared with the provisional guideline or parametric
values of the elements for drinking waters set by the WHO (World Health
Organization) and EC (European Commission). As, Cd, Cu, and Sb did not
exceed the WHO and EC provisional guideline or parametric values. However,
the other elements (Cr, Pb, Fe, Ni, and Mn) were found to be higher than
their relevant limits at various levels.
KW - Energy drinks
KW - ICP-MS
KW - Method validation
KW - Monitoring
KW - Proficiency tests
RN - 00BH33GNGH
RN - 0R0008Q3JB
RN - 2P299V784P
RN - 42Z2K6ZL8P
RN - 789U1901C5
RN - 7OV03QG267
RN - 9IT35J3UV3
RN - E1UOL152H7
RN - N712M78A8G
LA - eng
IS - 1573-2959 (Electronic)
PT - Journal Article
PT - Validation Studies
TA - Environ Monit Assess
YR - 2018
DATE- 20180614
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Environmental monitoring and assessment
EDAT- 20180309
STAT- MEDLINE
CM - Cites: Environ Monit Assess. 2014 Dec;186(12):8499-507 (medline /25179943)
CM - Cites: Biol Trace Elem Res. 2016 Apr;170(2):485-95 (medline /26286964)
CM - Cites: J Mass Spectrom. 2007 Apr;42(4):419-27 (medline /17385793)
CM - Cites: J AOAC Int. 2001 May-Jun;84(3):936-9 (medline /11417656)
CM - Cites: Sci Total Environ. 1999 Oct 29;241(1-3):143-50 (medline /10588071)
CM - Cites: J Agric Food Chem. 2005 Oct 5;53(20):7863-9 (medline /16190643)
CM - Cites: J Environ Biol. 2005 Jun;26(2 Suppl):301-13 (medline /16334259)
CM - Cites: Clin Lab Med. 2006 Mar;26(1):67-97, viii (medline /16567226)
CM - Cites: Toxicol Rep. 2015 Feb 07;2:384-390 (medline /28962372)
CM - Cites: Toxics. 2016 Dec 22;5(1):null (medline /29051433)
DOCNO- medline/29520489

345 - TOXLINE
TI - Comparative In Vitro Toxicity Evaluation of Heavy Metals (Lead, Cadmium,
Arsenic, and Methylmercury) on HT-22 Hippocampal Cell Line.
AU - Karri V
AD - Environmental Engineering Laboratory, Departament d'Enginyeria Quimica,
Universitat Rovira i Virgili, Av. Pa�sos Catalans 26, 43007, Tarragona, Spain.
AU - Kumar V
AD - Environmental Engineering Laboratory, Departament d'Enginyeria Quimica,
Universitat Rovira i Virgili, Av. Pa�sos Catalans 26, 43007, Tarragona, Spain.
vikas.kumar@urv.cat.
AU - Ramos D
AD - Plataforma de Prote�mica, Parc Cient�fic de Barcelona, C/ Baldiri Reixac, 10-
12, 08028, Barcelona, Spain.
AU - Oliveira E
AD - Unidad de Toxicologia, Parc Cient�fic de Barcelona, C/ Baldiri Reixac, 10-12,
08028, Barcelona, Spain.
AU - Schuhmacher M
AD - Environmental Engineering Laboratory, Departament d'Enginyeria Quimica,
Universitat Rovira i Virgili, Av. Pa�sos Catalans 26, 43007, Tarragona, Spain.
SO - Biol Trace Elem Res. 2018, Jul; 184(1):226-239. [Biological trace element
research]
AB - Heavy metals are considered some of the most toxic environmental
pollutants. Exposure to heavy metals including lead (Pb), cadmium (Cd),
arsenic (As), and methyl mercury (MeHg) has long been known to cause
damage to human health. Many recent studies have supported the hippocampus
as the major target for these four metals for inflicting cognitive
dysfunction. In the present study, we proposed hippocampal relevant in
vitro toxicity of Pb, Cd, As, and MeHg in HT-22 cell line. This study
reports, initially, cytotoxic effects in acute, subchronic, chronic
exposures. We further investigated the mechanistic potency of DNA damage
and apoptosis damage with the observed cytotoxicity. The genotoxicity and
apoptosis were measured by using the comet assay, annexin-V FTIC /
propidium iodide (PI) assay, respectively. The results of cytotoxicity
assay clearly demonstrated significant concentration and time-dependent
effects on HT-22 cell line. The genotoxic and apoptosis effects also
concentration-dependent fashion with respect to their potency in the range
of IC10-IC30, maximal level of damage observed in MeHg. In conclusion, the
obtained result suggests concentration and potency-dependent response; the
maximal level of toxicity was observed in MeHg. These novel findings
support that Pb, Cd, As, and MeHg induce cytotoxic, genotoxic, and
apoptotic effects on HT-22 cells in potency-dependent manner; MeHg >
As > Cd > Pb. Therefore, the toxicity of Pb, Cd, As, and MeHg could be
useful for knowing the common underlying molecular mechanism, and also for
estimating the mixture impacts on HT-22 cell line.
KW - Apoptosis
KW - DNA damage
KW - Dose response
KW - HT-22 cell line
KW - Heavy metals in vitro toxicity
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180608
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20171009
STAT- In-Process
DOCNO- medline/28994012

346 - TOXLINE
TI - Reducing Arsenic Concentration in Panax notoginseng via Contaminant
Immobilization in Soil Using Fe-Ce Oxide.
AU - Lin L
AU - Zhong L
AU - Yan X
AU - Fei Y
SO - J Environ Qual. 2018, Mar; 47(2):312-317. [Journal of environmental
quality]
AB - (Burk.) F.H. Chen, a valuable Chinese medicine, is currently confronted
with arsenic (As) contamination in China due to soil pollution. Our
previous research demonstrated that Fe(0) and zeolite had a certain
inhibitory effect on As accumulation in . In order to further reduce As
accumulation in the plant, a synthetic iron material (Fe-Ce oxide [FC])
with high As adsorption capacity was tested for As remediation. In the
study, after FC was applied to the As-contaminated soil, was planted in
the soil. The As leaching behavior of the treated soil and As accumulation
in were evaluated. The results showed that FC immobilized As more
effectively than Fe(0) and zeolite in soils with high As concentrations.
When the FC dosage was 0.5 % (w/w), As concentration of root (the main
medicinal part) decreased by 56%, and root biomass increased by 55%.
Results indicated FC could reduce the non-specifically adsorbed As
fraction (F1) and specifically adsorbed As fraction (F2) by 22 to 31% and
5 to 17%, respectively, thus reducing the toxicity characteristic leaching
procedure leachable As concentration by 41 to 67%. The finding of an iron
plaque coating on the plant root and its function as a barrier to As
uptake by is reported here for the first time. The occurrence of iron
plaque led to a reduction in As concentration in the phellem and
xylem-phloem by 66 to 80% and 43 to 70%, respectively. Our findings will
help in developing As contamination control in areas where is planted and
set a foundation for a FC-based As immobilization technology.
LA - eng
IS - 0047-2425 (Print)
PT - Journal Article
TA - J Environ Qual
YR - 2018
DATE- 20180410
CI - Copyright &copy; by the American Society of Agronomy, Crop Science Society
of America, and Soil Science Society of America, Inc.
CITO- NLM
CS - United States
FJT - Journal of environmental quality
STAT- In-Data-Review
DOCNO- medline/29634792

347 - TOXLINE
TI - Characteristics of arsenic in humic substances extracted from natural
organic sediments.
AU - Hara J
AD - Geological Survey of Japan, National Institute of Advanced Industrial Science
and Technology, Higashi 1-1-1, Tsukuba, Ibaraki, 305-8567, Japan.
j.hara@aist.go.jp.
AU - Norota S
AD - Geological Survey of Hokkaido, Environmental and Geological Research
Department, Hokkaido Research Organization, Kita 19 Nishi 11, Kita-ku, Sapporo,
Hokkaido, 060-0819, Japan.
AU - Kawebe Y
AD - Geological Survey of Japan, National Institute of Advanced Industrial Science
and Technology, Higashi 1-1-1, Tsukuba, Ibaraki, 305-8567, Japan.
AU - Sugita H
AD - Geological Survey of Japan, National Institute of Advanced Industrial Science
and Technology, Higashi 1-1-1, Tsukuba, Ibaraki, 305-8567, Japan.
AU - Zhang M
AD - Geological Survey of Japan, National Institute of Advanced Industrial Science
and Technology, Higashi 1-1-1, Tsukuba, Ibaraki, 305-8567, Japan.
SO - Environ Sci Pollut Res Int. 2018, Jun; 25(16):15680-15691. [Environmental
science and pollution research international]
AB - The stability and dispersion of naturally occurring As have been receiving
increasing attention, because As is toxic and its contamination is a
widespread problem in many countries. This study investigated As
fractionation and speciation in organic sediments collected from different
depositional settings to elucidate the existence of stable As in humic
substances. Eleven organic sediment samples were collected from marine and
terrestrial alluvial regions in Hokkaido prefecture, Japan, and the
chemical fraction of As and species of humic substances were identified by
sequential extraction. In addition, stable As bound in organic matter was
evaluated by FT-IR spectroscopy. The As fraction mainly comprised
inorganic substances, especially sulfur, iron, and manganese, and
terrestrial sediments (lacustrine and inland deposits) were rich in
sulfides and Fe and Al (hydr)oxides. When the residual fraction was
excluded, the organic fraction of As was higher in seawater sediments than
in terrestrial sediments. Among humic substances, cellulose, humic acid,
and hydrophilic fulvic acid were clearly associated with As accumulation,
and As speciation showed that the As was of organic origin. Cellulose, an
organic compound of plant origin, was abundant in As=S and As (III)=O
bonds, and As accumulation was higher in sulfur-rich peat sediments,
corresponding with the physiological activities of As in plants.
Hydrophilic fulvic acid and humic acid in these sediments, originating
from small animals and microorganisms in addition to plants, denote higher
As contents and abound in As (III, V)=C and C-H, CH3 bonds even in
sulfur-rich sediments. The methylated As bonds reflect the ecological
transition of organisms.
KW - Arsenic
KW - Bioaccumulation
KW - Chemical extraction
KW - Depositional setting
KW - Humic substances
KW - Organic sediments
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180608
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180325
STAT- In-Process
CM - Cites: Aquat Toxicol. 2008 Jan 31;86(2):205-15 (medline /18096252)
CM - Cites: Chemosphere. 2004 Sep;56(11):1105-12 (medline /15276723)
CM - Cites: J Hazard Mater. 2013 Nov 15;262:970-9 (medline /22964390)
CM -Cites: ScientificWorldJournal. 2014;2014:304524 (medline /25374935)
CM -Cites: J Hazard Mater. 2013 Nov 15;262:980-8 (medline /22809631)
CM -Cites: J Environ Qual. 2002 Jul-Aug;31(4):1115-23 (medline /12175028)
CM -Cites: Anal Chem. 2010 Jul 1;82(13):5534-40 (medline /20524641)
CM -Cites: Chemosphere. 2011 Jun;84(2):234-40 (medline /21530997)
CM -Cites: Environ Sci Technol. 2010 Jun 15;44(12):4479-85 (medline /20433135)
CM -Cites: Environ Pollut. 2004 Oct;131(3):337-45 (medline /15261396)
CM -Cites: Chemosphere. 2003 Jun;51(8):757-63 (medline /12668034)
CM -Cites: Toxicol Lett. 2007 Aug;172(3):91-105 (medline /17624697)
CM -Cites: Sci Total Environ. 2006 Feb 1;354(2-3):179-90 (medline /16398994)
CM -Cites: Biomed J. 2016 Feb;39(1):5-13 (medline /27105594)
CM -Cites: Toxicol Appl Pharmacol. 2000 Mar 1;163(2):203-7 (medline /10698679)
CM -Cites: J Contam Hydrol. 2011 Nov 1;126(3-4):216-25 (medline /22115087)
CM -Cites: Water Res. 2010 Nov;44(19):5556-74 (medline /20875661)
CM -Cites: Environ Sci Technol. 2006 Nov 1;40(21):6568-74 (medline /17144279)
CM -Cites: Chemosphere. 2009 Apr;75(2):156-62 (medline /19157491)
CM -Cites: Science. 2002 Nov 22;298(5598):1602-6 (medline /12446905)
CM -Cites: J Colloid Interface Sci. 2015 Dec 15;460:310-20 (medline /26348657)
CM -Cites: Metallomics. 2010 Apr;2(4):261-70 (medline /21069168)
CM -Cites: J Colloid Interface Sci. 2001 Feb 1;234(1):204-216 (medline
/11161507)
CM - Cites: Environ Sci Technol. 2011 Nov 15;45(22):9550-7 (medline /21985502)
CM - Cites: Talanta. 2015 Mar;134:530-537 (medline /25618704)
CM - Cites: Environ Sci Technol. 2006 Sep 1;40(17):5380-7 (medline /16999114)
CM - Cites: Environ Sci Technol. 2011 Apr 15;45(8):3210-6 (medline /21322632)
CM - Cites: Chemosphere. 2010 Nov;81(7):890-6 (medline /20801484)
CM - Cites: Chemosphere. 2009 Jan;74(2):274-9 (medline /18977015)
CM - Cites: Environ Sci Technol. 2006 Oct 1;40(19):6015-20 (medline /17051793)
CM - Cites: J Hazard Mater. 2014 Aug 30;279:569-78 (medline /25108831)
CM - Cites: J Hazard Mater. 2009 Sep 15;168(2-3):721-6 (medline /19297087)
CM - Cites: Sci Total Environ. 2014 Jan 15;468-469:1014-27 (medline /24095965)
CM - Cites: Environ Sci Technol. 2008 Jun 15;42(12):4268-73 (medline /18605543)
CM - Cites: J Hazard Mater. 2007 Mar 6;141(1):53-60 (medline /16890346)
DOCNO- medline/29574644

348 - TOXLINE
TI - Toxic metal(loid)-based pollutants and their possible role in autism
spectrum disorder.
AU - Bj�rklund G
AD - Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
Electronic address: bjorklund@conem.org.
AU - Skalny AV
AD - Peoples' Friendship University of Russia (RUDN University), Moscow, Russia;
Yaroslavl State University, Yaroslavl, Russia; All-Russian Research Institute of
Medicinal and Aromatic Plants, Moscow, Russia.
AU - Rahman MM
AD - Department of Environmental Sciences, Jahangirnagar University, Dhaka,
Bangladesh; Graduate School of Environmental Science, Hokkaido University, Japan.
AU - Dadar M
AD - Razi Vaccine and Serum Research Institute, Agricultural Research, Education
and Extension Organization (AREEO), Karaj, Iran.
AU - Yassa HA
AD - Faculty of Medicine, Assiut University, Assiut, Egypt.
AU - Aaseth J
AD - Faculty of Health and Social Sciences, Inland Norway University of Applied
Sciences, Elverum, Norway; Department of Research, Innlandet Hospital Trust,
Brumunddal, Norway.
AU - Chirumbolo S
AD - Department of Neurological and Movement Sciences, University of Verona,
Verona, Italy.
AU - Skalnaya MG
AD - Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.
AU - Tinkov AA
AD - Peoples' Friendship University of Russia (RUDN University), Moscow, Russia;
Yaroslavl State University, Yaroslavl, Russia.
SO - Environ Res. 2018, Jun 11; 166:234-250. [Environmental research]
AB - Autism spectrum disorder (ASD) is a neurodevelopmental disorder
characterized by deficits in social interaction, verbal and non-verbal
communication, and stereotypic behaviors. Many studies support a
significant relationship between many different environmental factors in
ASD etiology. These factors include increased daily exposure to various
toxic metal-based environmental pollutants, which represent a cause for
concern in public health. This article reviews the most relevant toxic
metals, commonly found, environmental pollutants, i.e., lead (Pb), mercury
(Hg), aluminum (Al), and the metalloid arsenic (As). Additionally, it
discusses how pollutants can be a possible pathogenetic cause of ASD
through various mechanisms including neuroinflammation in different
regions of the brain, fundamentally occurring through elevation of the
proinflammatory profile of cytokines and aberrant expression of nuclear
factor kappa B (NF-&kappa;B). Due to the worldwide increase in toxic
environmental pollution, studies on the role of pollutants in
neurodevelopmental disorders, including direct effects on the developing
brain and the subjects' genetic susceptibility and polymorphism, are of
utmost importance to achieve the best therapeutic approach and preventive
strategies.
KW - Aluminum
KW - Arsenic
KW - Autism
KW - Inflammatory response
KW - Lead
KW - Mercury
KW - Neuroinflammation
LA - eng
IS - 1096-0953 (Electronic)
PT - Journal Article
PT - Review
TA - Environ Res
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Environmental research
EDAT- 20180611
STAT- Publisher
DOCNO- medline/29902778

349 - TOXLINE
TI - Estimation of daily intake of arsenolipids in Japan based on a market
basket survey.
AU - Amin MHA
AD - Department of Environmental Studies, The University of Tokyo, Kashiwa, Chiba
277-8563, Japan.
AU - Xiong C
AD - Institute of Chemistry- NAWI Graz, University of Graz, Universitaetsplatz 1,
8010 Graz, Austria.
AU - Glabonjat RA
AD - Institute of Chemistry- NAWI Graz, University of Graz, Universitaetsplatz 1,
8010 Graz, Austria.
AU - Francesconi KA
AD - Institute of Chemistry- NAWI Graz, University of Graz, Universitaetsplatz 1,
8010 Graz, Austria.
AU - Oguri T
AD - National Institute for Environmental Studies, Onogawa 16-2, Tsukuba, Ibaraki
305-8506, Japan.
AU - Yoshinaga J
AD - Faculty of Life Sciences, Toyo University, Izumino 1-1-1, Itakura, Ora, Gunma
374-0193, Japan. Electronic address: yoshinaga@toyo.jp.
SO - Food Chem Toxicol. 2018, May 10; 118:245-251. [Food and chemical
toxicology : an international journal published for the British Industrial
Biological Research Association]
AB - Arsenolipid concentrations were measured in 17 food composites prepared
from 152 food items purchased in Shizuoka city, Japan, to (1) determine
the food contributing to daily intake of arsenolipids, and (2) estimate
the daily intake of arsenolipids. Analysis of arsenolipids was performed
by high performance liquid chromatography-inductively coupled plasma mass
spectrometry/electrospray ionization tandem mass spectrometry
(HPLC-ICP-MS/ESI-MS-MS). Arsenic containing hydrocarbons (AsHCs), arsenic
containing fatty acids (AsFAs), and arsenosugar phospholipids (AsSugPLs)
were detected only in "algae" and "fish and shellfish" of the 17 food
composites in a concentration range of 4.4-233&#8239;ng As/g fresh weight
(fw). Two cytotoxic arsenolipids, AsHC332 and AsHC360, were detected in
"algae" and "fish and shellfish" in the concentrations range of
33-40&#8239;ng As/g fw. The estimated average daily intake of AsHC332 and
AsHC360 was ca 3000 and 360&#8239;ng As/person/day, or 50 and 6.0&#8239;ng
As/kg bw/day, respectively. The present study indicated that arsenolipids
from "algae" and "fish and shellfish" consumption contributed to the daily
intake of toxic AsHCs, though the margin of exposure for the AsHC332 and
AsHC360 does not appear to pose a health risk for the general Japanese
population.
KW - Algae
KW - Arsenolipids
KW - Daily intake
KW - Fish and shellfish
KW - Health risk
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018. Published by Elsevier Ltd.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180510
STAT- Publisher
DOCNO- medline/29752981

350 - TOXLINE
TI - Human health tradeoffs in wellhead drinking water treatment: Comparing
exposure reduction to embedded life cycle risks.
AU - Gifford M
AD - Arizona State University, School of Sustainable Engineering and the Built
Environment, Tempe, AZ 85281, USA.
AU - Chester M
AD - Arizona State University, School of Sustainable Engineering and the Built
Environment, Tempe, AZ 85281, USA.
AU - Hristovski K
AD - Arizona State University, The Polytechnic School, Mesa, AZ 85212, USA.
AU - Westerhoff P
AD - Arizona State University, School of Sustainable Engineering and the Built
Environment, Tempe, AZ 85281, USA. Electronic address: p.westerhoff@asu.edu.
SO - Water Res. 2018, 01 01; 128:246-254. [Water research]
AB - Treatment of drinking water decreases human health risks by reducing
pollutants, but the required materials, chemicals, and energy emit
pollutants and increase health risks. We explored human carcinogenic and
non-carcinogenic disease tradeoffs of water treatment by comparing
pollutant dose-response curves against life cycle burden using USEtox
methodology. An illustrative wellhead sorbent groundwater treatment system
removing hexavalent chromium or pentavalent arsenic serving 3200 people
was studied. Reducing pollutant concentrations in drinking water from
20 &mu;g L-1 to 10 &mu;g L-1 avoided 37 potential
cancer cases and 64 potential non-cancer disease cases. Human
carcinogenicity embedded in treatment was 0.2-5.3 cases, and
non-carcinogenic toxicity was 0.2-14.3 cases, depending on technology and
degree of treatment. Embedded toxicity impacts from treating Cr(VI) using
strong-base anion exchange were < 10% of those from using weak base
anion exchange. Acidification and neutralization contributed > 90% of
the toxicity impacts for treatment options requiring pH control. In
scenarios where benefits exceeded burdens, tradeoffs still existed.
Benefits are experienced by a local population but burdens are born
externally where the materials and energy are produced, thus exporting the
health risks. Even when burdens clearly exceeded benefits, cost
considerations may still drive selecting a detrimental treatment level or
technology.
KW - *Arsenic
KW - *Hexavalent chromium
KW - *Life cycle assessment
KW - *Water treatment tradeoffs
LA - eng
IS - 1879-2448 (Electronic)
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
PT - Research Support, U.S. Gov't, Non-P.H.S.
TA - Water Res
YR - 2018
DATE- 20180409
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Water research
EDAT- 20171009
STAT- In-Process
DOCNO- medline/29107909

351 - TOXLINE
TI - Systematic Characterization of Stress-Induced RNA Granulation.
AU - Namkoong S
AD - Department of Molecular and Integrative Physiology, University of Michigan,
Ann Arbor, MI 48109, USA.
AU - Ho A
AD - Department of Molecular and Integrative Physiology, University of Michigan,
Ann Arbor, MI 48109, USA.
AU - Woo YM
AD - Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY
14853, USA.
AU - Kwak H
AD - Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY
14853, USA. Electronic address: hk572@cornell.edu.
AU - Lee JH
AD - Department of Molecular and Integrative Physiology, University of Michigan,
Ann Arbor, MI 48109, USA. Electronic address: leeju@umich.edu.
SO - Mol Cell. 2018, Apr 05; 70(1):175-187.e8. [Molecular cell]
AB - Upon stress, cytoplasmic mRNA is sequestered to insoluble
ribonucleoprotein (RNP) granules, such as the stress granule (SG).
Partially due to the belief that translationally suppressed mRNAs are
recruited to SGs in bulk, stress-induced dynamic redistribution of mRNA
has not been thoroughly characterized. Here, we report that endoplasmic
reticulum (ER) stress targets only a small subset of translationally
suppressed mRNAs into the insoluble RNP granule fraction (RG). This
subset, characterized by extended length and adenylate-uridylate (AU)-rich
motifs, is highly enriched with genes critical for cell survival and
proliferation. This pattern of RG targeting was conserved for two other
stress types, heat shock and arsenite toxicity, which induce distinct
responses in the total cytoplasmic transcriptome. Nevertheless,
stress-specific RG-targeting motifs, such as guanylate-cytidylate
(GC)-rich motifs in heat shock, were also identified. Previously
underappreciated, transcriptome profiling in the RG may contribute to
understanding human diseases associated with RNP dysfunction, such as
cancer and neurodegeneration.
KW - AU-rich elements
KW - ER stress
KW - RNA-seq
KW - RNP granule
KW - arsenite toxicity
KW - heat shock
KW - stress granule
KW - transcriptome
LA - eng
IS - 1097-4164 (Electronic)
PT - Journal Article
TA - Mol Cell
YR - 2018
DATE- 20180406
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Molecular cell
EDAT- 20180322
STAT- In-Data-Review
DOCNO- medline/29576526

352 - TOXLINE
TI - Defective magnesium ferrite nano-platelets for the adsorption of As(V):
The role of surface hydroxyl groups.
AU - Wu C
AD - School of Environment and Energy, South China University of Technology, The
Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters
(Ministry of Education), Guangdong Engineering and Technology Research Center for
Environmental Nanomaterials, Guangzhou Higher Education Mega Center, Guangzhou,
Guangdong 510006, China.
AU - Tu J
AD - School of Environment and Energy, South China University of Technology, The
Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters
(Ministry of Education), Guangdong Engineering and Technology Research Center for
Environmental Nanomaterials, Guangzhou Higher Education Mega Center, Guangzhou,
Guangdong 510006, China.
AU - Tian C
AD - School of Environment and Energy, South China University of Technology, The
Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters
(Ministry of Education), Guangdong Engineering and Technology Research Center for
Environmental Nanomaterials, Guangzhou Higher Education Mega Center, Guangzhou,
Guangdong 510006, China.
AU - Geng J
AD - School of Environment and Energy, South China University of Technology, The
Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters
(Ministry of Education), Guangdong Engineering and Technology Research Center for
Environmental Nanomaterials, Guangzhou Higher Education Mega Center, Guangzhou,
Guangdong 510006, China. Electronic address: estianchen@scut.edu.cn.
AU - Lin Z
AD - School of Environment and Energy, South China University of Technology, The
Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters
(Ministry of Education), Guangdong Engineering and Technology Research Center for
Environmental Nanomaterials, Guangzhou Higher Education Mega Center, Guangzhou,
Guangdong 510006, China. Electronic address: zlin@scut.edu.cn.
AU - Dang Z
AD - School of Environment and Energy, South China University of Technology, The
Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters
(Ministry of Education), Guangdong Engineering and Technology Research Center for
Environmental Nanomaterials, Guangzhou Higher Education Mega Center, Guangzhou,
Guangdong 510006, China.
SO - Environ Pollut. 2018, Apr; 235:11-19. [Environmental pollution (Barking,
Essex : 1987)]
AB - In this work, magnesium ferrite (MgFe2O4) nano-platelets with rich defects
and abundant surface hydroxyl groups were synthesized, and used for the
removal of low concentration As(V) in aqueous solution. Results from
scanning electron microscopy (SEM) showed that the as-synthesized MgFe2O4
nano-platelets were consisted of many individual nanospheres. Rietveld
refinement of X-ray diffraction (XRD) data indicated that the Mg2+ ions
substituted the Fe3+ ions at both the octahedral and the tetrahedral sites
of the crystal structure. Batch adsorption experiment showed that the
equilibrium concentration of As(V) could be reduced down to
4.9&#8239;&mu;g&middot;L-1 when the initial concentration of As(V) is
1&#8239;mg&middot;L-1, which complied with the drinking water standard of
WHO (10&#8239;&mu;g&middot;L-1). The adsorption capacity of synthesized
MgFe2O4 towards As(V) was higher than commonly used iron oxide adsorbents
(Fe3O4, &gamma;-Fe2O3 and &alpha;-Fe2O3). Mechanistic studies proved that
the superior adsorption capacity was attributed to: (1) increased amount
of surface hydroxyl groups that resulted from the surface defects. (2)
formation of tridentate hexanuclear surface complexes instead of bidentate
binuclear complexes, and (3) formation of excess Mg-OH surface hydroxyl
groups and As-Mg monodentate mononuclear surface complexes. This work
disclosed the correlation of the superior As(V) adsorption ability with
the surface hydroxyl groups in defective MgFe2O4, and propose MgFe2O4 as a
potential candidate for the remediation of As-contaminated water.
KW - Arsenic
KW - Defect
KW - Hydroxyl group
KW - Spinel ferrite
KW - Surface complex
RN - 12068-86-9
RN - 1K09F3G675
RN - 3352-57-6
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180523
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171220
STAT- MEDLINE
DOCNO- medline/29274533

353 - TOXLINE
TI - Ecological and health risks assessment and spatial distribution of
residual heavy metals in the soil of an e-waste circular economy park in
Tianjin, China.
AU - Han W
AD - Ministry of Education Key Laboratory of Pollution Processes and Environmental
Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering, Nankai University,
Tianjin 300350, China.
AU - Gao G
AD - Ministry of Education Key Laboratory of Pollution Processes and Environmental
Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering, Nankai University,
Tianjin 300350, China. Electronic address: gaoguanghai@homail.com.
AU - Geng J
AD - Ministry of Education Key Laboratory of Pollution Processes and Environmental
Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering, Nankai University,
Tianjin 300350, China.
AU - Li Y
AD - Ministry of Education Key Laboratory of Pollution Processes and Environmental
Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering, Nankai University,
Tianjin 300350, China.
AU - Wang Y
AD - Ministry of Education Key Laboratory of Pollution Processes and Environmental
Criteria, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering, Nankai University,
Tianjin 300350, China. Electronic address: wangyy@nankai.edu.cn.
SO - Chemosphere. 2018, Apr; 197:325-335. [Chemosphere]
AB - Ziya Circular Economy Park is the biggest e-waste recycle park in North
China before 2011, its function was then transformed in response to
regulations and rules. In this paper, investigation was conducted to
research the residual concentrations of 14 analytes (12 heavy metals and 2
non-metals) in the surface soil of Ziya Circular Economy Park and
surrounding area. Both ecological and health assessments were evaluated
using GI (geo-accumulation index) and NPI (Nemerow pollution index), and
associated health risk was assessed by using USEPA model. According to the
ecological risk assessment, Cu, Sb, Cd, Zn and Co were seriously enriched
in the soil of the studied area. The health risk assessment proposed by
USEPA indicated no significant health risks to the population. Soil
properties, such as pH and organic matter, were found to correlate with
the enrichment of heavy metals. Arsenic concentrations in the soil were
found positively correlated to dead bacteria concentrations. Spatial
distribution of heavy metals revealed that Ziya Circular Economy Park was
the dominant pollution source in the studied area. Findings in this study
suggest that enough attention should be payed to the heavy metal pollution
in Ziya Circular Economy Park.
KW - E-waste
KW - Geo-accumulation index (GI)
KW - Health risk
KW - Heavy metal
KW - Incremental lifetime cancer risk (ILCR)
KW - Nemerow Pollution index(NPI)
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180523
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180112
STAT- MEDLINE
DOCNO- medline/29366953

354 - TOXLINE
TI - Evaluation of Arsenic, Cadmium, Nickel and Lead in Common Spices in
Pakistan.
AU - Baig JA
AD - National Centre of Excellence in Analytical Chemistry, University of Sindh,
Jamshoro, 76080, Pakistan. jab_mughal@yahoo.com.
AU - Bhatti S
AD - National Centre of Excellence in Analytical Chemistry, University of Sindh,
Jamshoro, 76080, Pakistan.
AU - Kazi TG
AD - National Centre of Excellence in Analytical Chemistry, University of Sindh,
Jamshoro, 76080, Pakistan.
AU - Afridi HI
AD - National Centre of Excellence in Analytical Chemistry, University of Sindh,
Jamshoro, 76080, Pakistan.
SO - Biol Trace Elem Res. 2018, Jun 07. [Biological trace element research]
AB - The quantitative assessments and daily intake of arsenic (As), cadmium
(Cd), nickel (Ni) and lead (Pb) were conducted in the 26 common spices
collected from the market of Hyderabad, Pakistan. Conventional acid
digestion procedure was applied for dissolution of common spices and the
contents of toxic elemental were determined by graphite furnace atomic
absorption spectrometry. The conventional acid digestion method was
validated by certified reference materials and standard addition. A wide
variability was observed in the levels of toxic elements in common spices.
The toxic elements in common spices were found in decreasing order as
Ni&thinsp; > &thinsp;Pb&thinsp; > &thinsp;As&thinsp; > &thinsp;Cd. The
contents of As, Cd, Ni and Pb in common spices were observed highest in
coriander seed, allspices, nigella seed and black cumin seed,
respectively. The current study revealed that the toxic elements in common
spices were varied from region to region. However, the estimated intake of
As, Cd, Ni and Pb from common spices were within the WHO tolerable weekly
intake. The data of risk assessment indicated that As, Cd, Ni, and Pb in
common spices may not have any toxic risk except the As in carom,
coriander and nigella seeds.
KW - Common spices
KW - Estimated dietary intake
KW - Risk assessment
KW - Toxic elements
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180608
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180607
STAT- Publisher
DOCNO- medline/29882119

355 - TOXLINE
TI - Heavy metals and arsenic content in water along the southern Caspian
coasts in Iran.
AU - Abadi M
AD - Environmental Science Research Laboratory, Department of Environmental
Science, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran.
AU - Zamani A
AD - Environmental Science Research Laboratory, Department of Environmental
Science, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran.
zamani@znu.ac.ir.
AU - Parizanganeh A
AD - Environmental Science Research Laboratory, Department of Environmental
Science, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran.
AU - Khosravi Y
AD - Environmental Science Research Laboratory, Department of Environmental
Science, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran.
AU - Badiee H
AD - Department of Chemistry, Faculty of Science, Guilan University-University
Campus, Rasht, Iran.
SO - Environ Sci Pollut Res Int. 2018, Jun 06. [Environmental science and
pollution research international]
AB - Due to the importance of pollution monitoring in marine ecosystems and
lack of a coherent and systematic investigation of heavy metal ions along
the southern shores of the Caspian Sea, in the present study, the amount
of these metals and As ions in coastal waters along its 780-km-long coast
in Iran have been studied. Heavy metals (cobalt, nickel, copper, zinc,
cadmium, mercury, lead) and a poisonous metalloid (arsenic) were selected
in 59 sampling stations and determined using differential pulse
polarography method. The multivariate statistical tools were applied to
describe and interpret the experimental data. The overall mean
concentrations of studied metals (in microgram per liter; &mu;g L-1)
in the samples were found in the order Zn (10.9) > Ni (7.4) > Cu
(5.5) > Pb (1.9) > Hg (1.4) > As (1.3) > Co (1.1) > Cd
(0.2). The results when compared with reported international standards
confirmed that the sampled waters do contain some of these elements above
the suggested maximum permissible limits. Hg and Cu were detected in 54.2
and 72.9% of the samples, almost all above the permissible limits. Ni, Zn,
Pb, and Co were detected in 100, 96.6, 93.2, and 88.1%, respectively,
while 8.5, 22.0, 3.4, and 1.7% were above the permissible limits. Cd and
As were present in 61 and 93% of the samples, and their concentrations
were higher than the rate presented by Russian System of Management
Chemicals (RSMC). In addition, spatial distribution of heavy metal
concentrations showed that Gorgan Bay is an ecosystem serving as a filter,
trapping natural and anthropogenic materials that are brought from
industrial, commercial, and urbanized areas. The multivariate data
analysis reveals that Caspian Sea is contaminated by both anthropogenic as
well as pedo-geochemical sources.
KW - Coastal waters
KW - Contamination
KW - Differential pulse polarography
KW - Environmental impact
KW - Gorgan Bay, Iran
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180607
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180606
STAT- Publisher
DOCNO- medline/29876847

356 - TOXLINE
TI - Metals and arsenic in fish from a Ramsar site under past and present human
pressures: Consumption risk factors to the local population.
AU - Gusso-Choueri PK
AD - Post-Graduation Program in Ecology and Conservation, Universidade Federal do
Paran�, P.O. Box 19031, 81531-990 Curitiba, PR, Brazil; Laborat�rio de Toxicologia
Celular, Departamento de Biologia Celular, Universidade Federal do Paran�, CP19031,
81531-990 Curitiba, PR, Brazil; NEPEA, Campus do Litoral Paulista, Universidade
Estadual Paulista J�lio de Mesquita Filho, Pra�a Infante Dom Henrique, s/n, 11330-
900 S�o Vicente, SP, Brazil. Electronic address: pgusso@yahoo.com.br.
AU - Ara�jo GS
AD - NEPEA, Campus do Litoral Paulista, Universidade Estadual Paulista J�lio de
Mesquita Filho, Pra�a Infante Dom Henrique, s/n, 11330-900 S�o Vicente, SP, Brazil.
AU - Cruz ACF
AD - NEPEA, Campus do Litoral Paulista, Universidade Estadual Paulista J�lio de
Mesquita Filho, Pra�a Infante Dom Henrique, s/n, 11330-900 S�o Vicente, SP, Brazil.
AU - Stremel TRO
AD - Post-Graduation Program in Applied Chemistry, Universidade Estadual de Ponta
Grossa, Av. General Carlos Cavalcanti, 4748, 84030-900, Uvaranas, Ponta Grossa, PR,
Brazil.
AU - Campos SX
AD - Post-Graduation Program in Applied Chemistry, Universidade Estadual de Ponta
Grossa, Av. General Carlos Cavalcanti, 4748, 84030-900, Uvaranas, Ponta Grossa, PR,
Brazil.
AU - Abessa DMS
AD - NEPEA, Campus do Litoral Paulista, Universidade Estadual Paulista J�lio de
Mesquita Filho, Pra�a Infante Dom Henrique, s/n, 11330-900 S�o Vicente, SP, Brazil.
AU - Oliveira Ribeiro CA
AD - Post-Graduation Program in Ecology and Conservation, Universidade Federal do
Paran�, P.O. Box 19031, 81531-990 Curitiba, PR, Brazil; Laborat�rio de Toxicologia
Celular, Departamento de Biologia Celular, Universidade Federal do Paran�, CP19031,
81531-990 Curitiba, PR, Brazil.
AU - Choueri RB
AD - Departamento de Ci�ncias do Mar, Universidade Federal de S�o Paulo, Rua
Carvalho de Mendon�a, 144, 11070-100 Santos, SP, Brazil.
SO - Sci Total Environ. 2018, Jul 01; 628-629:621-630. [The Science of the
total environment]
AB - The risk of metals and As in seafood for traditional populations living in
a Marine Protected Areas (MPA) is seldom assessed, although the risk of
human exposure to contaminants is one of the indicators associated with
the socioeconomic goals of MPAs. The current study aimed to estimate the
potential risk of some metals (Cd, Pb, and Zn) and arsenic (As) for human
health through the ingestion of fish locally harvested in a Ramsar site,
the Canan�ia-Iguape-Peru�be Environmental Protected Area
(APA-CIP). Previous studies showed environmental impacts in this area due
to former mining activities and urbanization. Cathorops spixii, a catfish
largely consumed by the local population, was collected along the estuary
in three seasons with different rain regimes. Metals and As loads in
muscle tissue were quantified and it was estimated (i) the target hazard
quotient (THQ) and (ii) the daily intake (EDI) for metals and As, (iii)
the cancer risk (CRisk) only for As, and (iv) the number of eligible meals
per month. Cd, Pb, and As were found at concentrations above action levels
for human consumption. Depending on the level of exposure of the local
population, the consumption of C. spixii may pose risk to human health.
Highest THQs were estimated for fish collected in sites closer to the main
contamination sources in the APA-CIP, i.e. the mouth of Ribeira de Iguape
River (P1) and the city of Canan�ia (P4, P5, and P6). Arsenic
showed high levels of cancer risk, although restricted to the area close
to the city. The exposure of the local population to metal and As
contaminated seafood cannot be disregarded in environmental studies and
management of the APA-CIP.
KW - Allowable daily consumption
KW - Consumption limits
KW - Human exposure
KW - Mining activity
KW - Toxic metals
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180327
CI - Copyright &copy; 2018. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180220
STAT- In-Process
DOCNO- medline/29454203

357 - TOXLINE
TI - Monitoring of toxicity of As(V) solutions by AMPHITOX test without and
with treatment with zerovalent iron nanoparticles.
AU - P�rez Coll CS
AD - Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET),
Argentina; Instituto de Investigaci�n e Ingenier�a Ambiental, Universidad Nacional
de Gral. San Mart�n, Campus Miguelete, Av. 25 de Mayo y Francia, 1650, San Mart�n,
Provincia de Buenos Aires, Argentina; Escuela de Ciencia y Tecnolog�a, Instituto de
Investigaci�n e Ingenier�a Ambiental, Universidad Nacional de San Mart�n, Campus
Miguelete, Av.25 de Mayo y Francia, 1650, San Mart�n, Provincia de Buenos Aires,
Argentina. Electronic address: perezcoll@unsam.edu.ar.
AU - Pab�n-Reyes C
AD - Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET),
Argentina; Instituto de Investigaci�n e Ingenier�a Ambiental, Universidad Nacional
de Gral. San Mart�n, Campus Miguelete, Av. 25 de Mayo y Francia, 1650, San Mart�n,
Provincia de Buenos Aires, Argentina; Gerencia Qu�mica, Centro At�mico
Constituyentes, Comisi�n Nacional de Energ�a At�mica, Av. Gral. Paz 1499, 1650, San
Mart�n, Provincia de Buenos Aires, Argentina.
AU - Meichtry JM
AD - Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET),
Argentina; Gerencia Qu�mica, Centro At�mico Constituyentes, Comisi�n Nacional de
Energ�a At�mica, Av. Gral. Paz 1499, 1650, San Mart�n, Provincia de Buenos Aires,
Argentina.
AU - Litter MI
AD - Consejo Nacional de Investigaciones Cient�ficas y T�cnicas (CONICET),
Argentina; Instituto de Investigaci�n e Ingenier�a Ambiental, Universidad Nacional
de Gral. San Mart�n, Campus Miguelete, Av. 25 de Mayo y Francia, 1650, San Mart�n,
Provincia de Buenos Aires, Argentina; Gerencia Qu�mica, Centro At�mico
Constituyentes, Comisi�n Nacional de Energ�a At�mica, Av. Gral. Paz 1499, 1650, San
Mart�n, Provincia de Buenos Aires, Argentina.
SO - Environ Toxicol Pharmacol. 2018, Jun; 60:138-145. [Environmental
toxicology and pharmacology]
AB - Changes in toxicity of As(V) solutions from acute to chronic exposure have
been evaluated by the AMPHITOX test. This test employs Rhinella arenarum,
a widely distributed toad in Argentine areas. LOEC values were 6.37 and
1.88&#8239;mg L-1 for embryos and larvae, respectively, and serious
sublethal effects have been observed. Toxicity of As(V) solutions has been
also evaluated after treatment with zerovalent iron nanoparticles (nZVI).
After 60&#8239;min of treatment with nZVI, As(V) removal was 77%, and
neither lethal nor sublethal effects were observed. However, nZVI had to
be eliminated before the bioassay because they caused adverse effects in
both embryos and larvae. This work highlights the high sensitivity of R.
arenarum to As(V), the relevance to assess toxicity on different periods
of the lifecycle, and the need to expand exposure to As(V) to chronic
times. The utility of the test for monitoring toxicity changes in As(V)
solutions after nZVI treatment has been also shown.
KW - Arsenate
KW - Arsenic
KW - Rhinella arenarum
KW - Toxicity bioassays
KW - Zerovalent iron nanoparticles
LA - eng
IS - 1872-7077 (Electronic)
PT - Journal Article
TA - Environ Toxicol Pharmacol
YR - 2018
DATE- 20180615
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Environmental toxicology and pharmacology
EDAT- 20180424
STAT- In-Process
DOCNO- medline/29723714

358 - TOXLINE
TI - Simultaneous suppression of acid mine drainage formation and arsenic
release by Carrier-microencapsulation using aluminum-catecholate
complexes.
AU - Park I
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Graduate School of Engineering, Hokkaido
University, Japan. Electronic address: ihp2035@gmail.com.
AU - Tabelin CB
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University,
Japan.
AU - Seno K
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Graduate School of Engineering, Hokkaido
University, Japan.
AU - Jeon S
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Graduate School of Engineering, Hokkaido
University, Japan.
AU - Ito M
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University,
Japan.
AU - Hiroyoshi N
AD - Laboratory of Mineral Processing and Resources Recycling, Division of
Sustainable Resources Engineering, Faculty of Engineering, Hokkaido University,
Japan.
SO - Chemosphere. 2018, Aug; 205:414-425. [Chemosphere]
AB - Pyrite (FeS2), the most common sulfide mineral in nature, plays an
important role in the formation of acid mine drainage (AMD), one of the
most serious environmental problems after the closure of mines and mineral
processing operations. Likewise, arsenopyrite (FeAsS) is an important
sulfide mineral because its dissolution releases toxic arsenic (As) into
the environment. To mitigate the serious environmental problems caused by
pyrite and arsenopyrite, this study investigated
carrier-microencapsulation (CME) using Al-catecholate complexes, a
technique that selectively forms protective coatings on the surfaces of
sulfide minerals, by electrochemical techniques and batch leaching
experiments coupled with surface sensitive characterization techniques.
Cyclic voltammetry (CV) of Al-catecholate complexes (mono-, bis-,
tris-catecholate) suggest that these three species could be oxidatively
decomposed in this order:
[Al(cat)3]3-&rarr;[Al(cat)2]-&rarr;[Al(cat)]+&rarr;Al3+, and these
reactions were irreversible. Among these three species, [Al(cat)]+ was the
most effective in suppressing pyrite and arsenopyrite oxidations because
it requires less steps for complete decomposition than the other two
complexes. Analyses of CME treated minerals by scanning electron
microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and diffuse
reflectance infrared Fourier transform spectroscopy (DRIFTS) indicated
that they were covered with Al-oxyhydroxide (&gamma;-AlO(OH)), which
became more extensive at higher [Al(cat)]+ concentrations. In addition,
this coating was stable even at relatively high applied potentials that
simulated surface oxidizing conditions. Based on these results, a detailed
mechanism of Al-based CME is proposed: (1) adsorption of [Al(cat)]+ on the
surface of mineral, (2) oxidative decomposition of [Al(cat)]+ and release
of "free" Al3+, and (3) precipitation and formation of Al-oxyhydroxide
coating.
KW - Acid mine drainage
KW - Al-catecholate complexes
KW - Arsenopyrite
KW - Microencapsulation
KW - Pyrite
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180519
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20180416
STAT- In-Process
DOCNO- medline/29704849

359 - TOXLINE
TI - Direct Observation of Simultaneous Immobilization of Cadmium and Arsenate
at the Brushite-Fluid Interface.
AU - Zhai H
AD - College of Resources and Environment , Huazhong Agricultural University ,
Wuhan 430070 , P. R. China.
AU - Wang L
AD - College of Resources and Environment , Huazhong Agricultural University ,
Wuhan 430070 , P. R. China.
AU - Qin L
AD - College of Resources and Environment , Huazhong Agricultural University ,
Wuhan 430070 , P. R. China.
AU - Zhang W
AD - College of Resources and Environment , Huazhong Agricultural University ,
Wuhan 430070 , P. R. China.
AU - Putnis CV
AD - Institut f�r Mineralogie , University of M�nster , 48149 M�nster , Germany.
AU - Putnis A
AD - Institut f�r Mineralogie , University of M�nster , 48149 M�nster , Germany.
SO - Environ Sci Technol. 2018, Mar 20; 52(6):3493-3502. [Environmental science
& technology]
AB - Cadmium (Cd2+) and Arsenate (As5+) are the main toxic elements in soil
environments and are easily taken up by plants. Unraveling the kinetics of
the adsorption and subsequent precipitation/immobilization on mineral
surfaces is of considerable importance for predicting the fate of these
dissolved species in soils. Here we used in situ atomic force microscopy
(AFM) to image the dissolution on the (010) face of brushite (dicalcium
phosphate dihydrate, CaHPO4&middot;2H2O) in CdCl2- or Na2HAsO4-bearing
solutions over a broad pH and concentration range. During the initial
dissolution processes, we observed that Cd or As adsorbed on step edges to
modify the morphology of etch pits from the normal triangular shape to a
four-sided trapezium. Following extended reaction times, the respective
precipitates were formed on brushite through a coupled
dissolution-precipitation mechanism. In the presence of both CdCl2 and
Na2HAsO4 in reaction solutions at pH 8.0, high-resolution transmission
electron microscopy (HRTEM) showed a coexistence of both amorphous and
crystalline phases, i.e., a mixed precipitate of amorphous and crystalline
Cd(5- x)Ca x(AsO4)(3- y)(PO4) yOH phases was detected. These direct
dynamic observations of the transformation of adsorbed species to surface
precipitates may improve the mechanistic understanding of the calcium
phosphate mineral interface-induced simultaneous immobilization of both Cd
and As and subsequent sequestration in diverse soils.
LA - eng
IS - 1520-5851 (Electronic)
PT - Journal Article
TA - Environ Sci Technol
YR - 2018
DATE- 20180320
CITO- NLM
CS - United States
FJT - Environmental science &amp; technology
EDAT- 20180305
STAT- In-Data-Review
DOCNO- medline/29488373

360 - TOXLINE
TI - Capacity and recycling of polyoxometalate applied in As(III) oxidation by
Fe(II)-Amended zero-valent aluminum.
AU - Hsu LC
AD - Scientific Research Division, National Synchrotron Radiation Research Center,
101 Hsin-Ann Road, Hsinchu 300, Taiwan.
AU - Cho YL
AD - Department of Soil and Environmental Sciences, National Chung-Hsing
University, 145 Xingda Rd., Taichung 402, Taiwan.
AU - Liu YT
AD - Department of Soil and Environmental Sciences, National Chung-Hsing
University, 145 Xingda Rd., Taichung 402, Taiwan. Electronic address:
yliu@nchu.edu.tw.
AU - Tzou YM
AD - Department of Soil and Environmental Sciences, National Chung-Hsing
University, 145 Xingda Rd., Taichung 402, Taiwan.
AU - Teah HY
AD - Division of Environmental Studies, Graduate School of Frontier Sciences, The
University of Tokyo, 332 Building of Environmental Studies, 5-1-5 Kashiwanoha,
Kashiwa City, Chiba 277-8563, Japan.
SO - Chemosphere. 2018, Jun; 200:1-7. [Chemosphere]
AB - Arsenic remediation is often initiated by oxidizing As(III) to As(V) to
alleviate its toxicity and mobility. Due to the easy availability,
zero-valent Al (ZVAl) like Al can was considered as potential alternatives
to facilitate As(III) oxidation. This study determined the capability and
recycling of polyoxometalate (POM) to catalyze As(III) oxidation in
Fe(II)-amended ZVAl systems. POM acquired electrons from ZVAl more
effectively at pH 1 than at pH 2. While 76% of the reduced POM [POM(e-)]
reacted with O2(g) to generate H2O2 at pH 1, only 60% of POM(e-) was used
to produce H2O2 at pH 2. The remaining POM(e-) was oxidized by the
generated H2O2. Such additional consumption of POM(e-) and H2O2 led to the
incomplete As(III) oxidation in the system without residual ZVAl and
emphasized the need for a continuous electron supply from ZVAl to
compensate the depletion of POM(e-). After the hydrolyzation at pH 6.0,
the XANES data evidenced that not only As(V) but WO4 released from the POM
retained on surfaces of Al/Fe hydroxides. The competition for sorption
sites on Al/Fe hydroxides between As(V) and WO4 led to the incomplete As
removal. Despite the loss of WO4, the POM re-polymerized at pH 1 still
showed the comparable capability to catalyze As(III) oxidation with
original POM. This study revealed electron transfer pathways from ZVAl to
As(III) as catalyzed by POM and evidenced the effective POM recycling
after As removal, which lowers the cost of POM application and turns the
ZVAl/Fe(II)/POM/O2 system into a practical strategy for As remediation.
KW - Arsenic
KW - Oxidation
KW - Polyoxometalate
KW - Recycling
KW - Zero-valent aluminum
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180319
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20180212
STAT- In-Process
DOCNO- medline/29471163

361 - TOXLINE
TI - Chronic kidney disease of unknown etiology and the effect of
multiple-ion interactions.
AU - Dharma-Wardana MWC
AD - Universit� de Montreal, Montreal, H3C 3J7l, Canada. chandre.dharma-
wardana@nrc-cnrc.gc.ca.
SO - Environ Geochem Health. 2018, Apr; 40(2):705-719. [Environmental
geochemistry and health]
AB - High incidence of chronic kidney disease of unknown etiology (CKDU)
prevalent in many countries (e.g., Sri Lanka, equatorial America) is
reviewed in the context of recent experimental work and using our
understanding of the hydration of ions and proteins. Qualitative
considerations based on Hofmeister-type action of these ions, as well as
quantitative electrochemical models for the Gibbs free energy change for
ionpair formation, are used to explain why (1) fluoride and water hardness
due to magnesium ions (but not due to calcium ions) and similarly (2)
cadmium ions in the presence of suitable pairing ions can be expected to
be more nephrotoxic, while arsenite in the presence of fluoride and
hardness may be expected to be less nephrotoxic. No synergy of arsenic
with calcium hardness is found. The analysis is applied to a variety of
ionic species that may be found in typical water sources to predict their
likely combined electrochemical action. These results clarify the origins
of chronic kidney disease that has reached epidemic proportions in the
North Central Province of Sri Lanka as being most likely due to the joint
presence of fluoride and magnesium ions in drinking water. The conclusion
is further strengthened by a study of the dietary load of Cd and other
toxins in the affected regions and in the healthy regions where the
dietary toxin loads and lifestyles are similar, and found to be safe
especially when the mitigating effects of micronutrient ionic forms of Zn,
Se, as well as corrections for bioavailability are taken into account. The
resulting etiological picture is consistent with the views of most workers
in the field who have suspected that fluoride and other ions found in the
hard water stagnant in shallow household wells were the major causative
factors of the disease. Similar incidence of CKDu found in other hot
tropical climates is likely to have similar origins.
KW - Electrolytes
KW - Fertilizers
KW - Fluoride
KW - Kidney disease
KW - Metal toxins
KW - Protein denaturing
KW - Soils
KW - Sri Lanka
KW - Water quality
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180318
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20170901
STAT- In-Process
CM - Cites: Sci Rep. 2017 Feb 14;7:42516 (medline /28195172)
CM - Cites: Arh Hig Rada Toksikol. 2011 Mar;62(1):65-76 (medline /21421535)
CM - Cites: Inorg Chem. 2004 May 3;43(9):2954-9 (medline /15106984)
CM - Cites: BMC Nephrol. 2014 Feb 21;15:36 (medline /24559433)
CM - Cites: Environ Geochem Health. 2013 Aug;35(4):439-54 (medline /23475496)
CM - Cites: Biophys J. 1997 Jan;72(1):65-76 (medline /8994593)
CM - Cites: Environ Geochem Health. 2016 Jun;38(3):679-90 (medline /26183039)
CM - Cites: BMC Nephrol. 2015 Aug 19;16:145 (medline /26282933)
CM - Cites: Chem Soc Rev. 2014 Nov 7;43(21):7358-77 (medline /25099516)
CM - Cites: Springerplus. 2015 Feb 24;4:90 (medline /25763302)
CM - Cites: Environ Geochem Health. 2005 Feb;27(1):55-64 (medline /15688131)
CM - Cites: Environ Geochem Health. 2015 Apr;37(2):221-31 (medline /25119535)
CM - Cites: Springerplus. 2016 Oct 24;5(1):1864 (medline /27843741)
CM - Cites: Biomed Environ Sci. 2006 Dec;19(6):439-44 (medline /17319268)
CM - Cites: Environ Sci Technol. 2013 Jun 4;47(11):5613-8 (medline /23668419)
CM - Cites: BMC Nephrol. 2014 Jun 13;15:90 (medline /24927636)
CM - Cites: Environ Sci Technol. 2009 Mar 1;43(5):1612-7 (medline /19350943)
CM - Cites: ChemMedChem. 2012 Jun;7(6):977-82 (medline /22555964)
CM - Cites: J Occup Health. 2014;56(1):28-38 (medline /24351856)
CM - Cites: Rev Environ Contam Toxicol. 2008;192:29-66 (medline /18020303)
CM - Cites: Food Chem Toxicol. 2001 Oct;39(10):967-80 (medline /11524135)
CM - Cites: Nefrologia. 2005;25(1):31-8 (medline /15789534)
CM - Cites: Environ Int. 2016 Mar;88:299-309 (medline /26851498)
CM - Cites: Ceylon Med J. 2013 Mar;58(1):6-10 (medline /23549716)
CM - Cites: Int J Environ Res Public Health. 2014 Feb 20;11(2):2125-47 (medline
/24562182)
CM - Cites: BMC Nephrol. 2013 Aug 27;14:180 (medline /23981540)
CM - Cites: BMC Nephrol. 2011 Jul 05;12:32 (medline /21726464)
CM - Cites: Curr Med Chem. 2011;18(17):2630-7 (medline /21568886)
DOCNO- medline/28864964

362 - TOXLINE
TI - On the aqueous solvation of AsO(OH)3vs. As(OH)3. Born-Oppenheimer
molecular dynamics density functional theory cluster studies.
AU - Ram�rez-Sol�s A
AD - Depto. de F�sica, Centro de Investigaci�n en Ciencias, IICBA, Universidad
Aut�noma del Estado de Morelos, Cuernavaca, Morelos 62209, Mexico. alex@uaem.mx.
AU - Amaro-Estrada JI
AD - Instituto de Ciencias F�sicas, Universidad Nacional Aut�noma de M�xico, Apdo.
Postal 48-3, Cuernavaca, Morelos 62251, Mexico.
AU - Le�n-Pimentel CI
AD - Instituto de Ciencias F�sicas, Universidad Nacional Aut�noma de M�xico, Apdo.
Postal 48-3, Cuernavaca, Morelos 62251, Mexico.
AU - Hern�ndez-Cobos J
AD - Instituto de Ciencias F�sicas, Universidad Nacional Aut�noma de M�xico, Apdo.
Postal 48-3, Cuernavaca, Morelos 62251, Mexico.
AU - Garrido-Hoyos SE
AD - Instituto Mexicano de Tecnolog�a del Agua, Jiutepec, Morelos 62550, Mexico.
AU - Saint-Martin H
AD - Instituto de Ciencias F�sicas, Universidad Nacional Aut�noma de M�xico, Apdo.
Postal 48-3, Cuernavaca, Morelos 62251, Mexico.
SO - Phys Chem Chem Phys. 2018, Jun 06. [Physical chemistry chemical physics :
PCCP]
AB - While arsenous acid, As(OH)3, has been the subject of a plethora of
studies due to its worldwide ubiquity and its toxicity, pentavalent As in
the form of arsenic acid, AsO(OH)3, has recently been found in rivers in
central Mexico as the most abundant naturally occurring arsenic species.
To better understand the solvation patterns of both toxic acids at the
molecular level, we report the results of Born-Oppenheimer molecular
dynamics simulations on the aqueous solvation of the AsO(OH)3 and As(OH)3
molecules at room temperature using the cluster microsolvation approach
including 30 water molecules at the B3LYP/6-31G** level of theory. We
found that the average per-molecule water binding energy is ca. 1 kcal
mol-1 larger for the As(v) species as compared to the As(iii) one. To
account for the asymmetry of both molecules, the hydration patterns were
studied separately for a "lower" hemisphere, defined by the initially
protonated oxygens, and for the opposite "upper" hemisphere. Similar lower
hydration patterns were found for both As(iii) and As(v), with the same
coordination number CN = 7. The upper pattern for As(iii) was found to be
of a hydrophobic type, whereas that for As(v) showed the fourth oxygen to
be hydrogen-bonded to the water network, yielding CN = 3.7; moreover, a
proton "hopped" from the lower to the upper side, through the Grotthuss
mechanism. Theoretical EXAFS spectra were obtained that showed good
agreement with experimental data for As(iii) and As(v) in liquid water,
albeit with somewhat longer As-O distances due to the level of theory
employed. Proton transfer processes were also addressed; we found that the
singly deprotonated H2AsO3- species largely dominated (99% of the
simulation) for the As(iii) case, and that the deprotonated H2AsO4- and
HAsO42- species were almost equally present (45% and 55%, respectively)
for the As(v) case, which is in line with the experimental data pKa1 =
2.24 and pKa2 = 6.96. Through vibrational analysis the features of the
Eigen and Zundel ions were found in the spectra of the microsolvated
As(iii) and As(v) species, in good agreement with experimental data in
aqueous solutions.
LA - eng
IS - 1463-9084 (Electronic)
PT - Journal Article
TA - Phys Chem Chem Phys
YR - 2018
DATE- 20180606
CITO- NLM
CS - England
FJT - Physical chemistry chemical physics : PCCP
EDAT- 20180606
STAT- Publisher
DOCNO- medline/29873361

363 - TOXLINE
TI - Toxic heavy metals in human blood in relation to certain food and
environmental samples in Kerala, South India.
AU - Jose A
AD - Department of Zoology, Assumption College, Changanacherry, Kottayam, Kerala,
India.
AU - Ray JG
AD - School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala, India.
jgray@mgu.ac.in.
SO - Environ Sci Pollut Res Int. 2018, Mar; 25(8):7946-7953. [Environmental
science and pollution research international]
AB - Toxic heavy metals such as arsenic (As), lead (Pb), and mercury (Hg) are
systemic toxicants that are hazardous to human health. However, as these
elements are increasing in the environment due to fast urbanization,
industrialization, and chemicalized agricultural activities, accumulation
of the same in human body anywhere in the world is quite interesting to
global assessment of environment quality. In this connection, random
examination of blood samples of human population in Kerala, South India,
was carried out to assess the threat of heavy metal contamination to
humans in this part of the globe, especially in relation to the amount of
such metals in food and other environmental samples. Except pure
vegetarians, people of Kerala consume rice as the staple food with a lot
of fish. Therefore, the amount of these three heavy metals in drinking
water, fish, rice, and paddy soils was done. Heavy metals in the blood
were examined in relation to age, gender, and dietary habits such as
frequency of fish eating or vegetarianism. Influence of dental amalgam
fillings on blood mercury levels was also analyzed. Quantitative
assessment of metals in samples was done by inductively coupled
plasma-mass spectrometry (ICP-MS). The levels of arsenic, lead, and
mercury were found well below the reference values, though diet seemed to
pull them up as the amount of metals in blood showed significant
differences between vegetarians and non-vegetarians. Evidence to the
influence of dental amalgam fillings on blood mercury levels could not be
established with the present samples.
KW - Arsenic
KW - Heavy metal contamination
KW - Human blood
KW - Lead
KW - Mercury
KW - Metal toxicity
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180318
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180104
STAT- In-Process
CM - Cites: Indian J Pharmacol. 2011 May;43(3):246-53 (medline /21713085)
CM - Cites: Ind Health. 2000 Apr;38(2):153-64 (medline /10812838)
CM - Cites: Int J Mol Sci. 2015 Dec 10;16(12):29592-630 (medline /26690422)
CM - Cites: Int J Environ Res Public Health. 2010 Jun;7(6):2666-91 (medline
/20644695)
CM - Cites: J Toxicol. 2014;2014:401012 (medline /25349606)
CM - Cites: Int J Clin Pediatr Dent. 2014 Sep-Dec;7(3):180-5 (medline
/25709298)
CM - Cites: Int J Occup Med Environ Health. 2001;14(3):223-9 (medline
/11764849)
CM - Cites: J Trace Elem Med Biol. 2014 Jan;28(1):32-4 (medline /24210170)
CM - Cites: Environ Monit Assess. 2012 Jul;184(7):4233-45 (medline /21822576)
CM - Cites: J Trace Elem Med Biol. 2006;20(4):253-62 (medline /17098585)
CM - Cites: Sci Total Environ. 1990 Jun;95:89-105 (medline /2402627)
CM - Cites: Environ Sci Pollut Res Int. 2017 Aug;24(22):18010-18024 (medline
/28624940)
CM - Cites: Biomed Res Int. 2014;2014:545473 (medline /24995308)
CM - Cites: Talanta. 2002 Aug 16;58(1):201-35 (medline /18968746)
CM - Cites: J Matern Fetal Neonatal Med. 2016 Nov;29(22):3665-9 (medline
/26898132)
CM - Cites: Environ Toxicol Pharmacol. 2008 Nov;26(3):263-71 (medline
/21791373)
CM - Cites: Int J Hyg Environ Health. 2016 Jul;219(4-5):412-8 (medline
/27107843)
CM - Cites: Sci Total Environ. 2016 Jan 15;541:149-154 (medline /26406109)
CM - Cites: J Trace Elem Med Biol. 2012 Oct;26(4):215-26 (medline /22658719)
CM - Cites: Environ Sci Technol. 2005 Aug 1;39(15):5531-40 (medline /16124284)
CM - Cites: Environ Res. 2013 Oct;126:118-24 (medline /23890969)
CM - Cites: Int J Hyg Environ Health. 2002 Apr;205(3):205-11 (medline
/12040918)
CM - Cites: Clin Chem. 1988 Mar;34(3):474-81 (medline /3280162)
CM - Cites: J Adhes Dent. 2012 Aug;14(5):407-31 (medline /23082310)
CM - Cites: Sci Total Environ. 1995 Apr 21;166:89-135 (medline /7754357)
CM - Cites: J Trace Elem Med Biol. 2015 Apr;30:66-76 (medline /25467850)
CM - Cites: Environ Health Perspect. 2009 Dec;117(12):1860-6 (medline
/20049204)
CM - Cites: J Dent Res. 1989 May;68(5):780-5 (medline /2715470)
DOCNO- medline/29302906

364 - TOXLINE
TI - Interaction of Arsenous Acid with the Dithiol-Type Chelator British
Anti-Lewisite (BAL): Structure and Stability of Species Formed in an
Unexpectedly Complex System.
AU - Szekeres LI
AD - Department of Inorganic and Analytical Chemistry , University of Szeged , D�m
t�r 7 , Szeged H-6720 , Hungary.
AU - Gyurcsik B
AD - Department of Inorganic and Analytical Chemistry , University of Szeged , D�m
t�r 7 , Szeged H-6720 , Hungary.
AU - Kiss T
AD - Department of Inorganic and Analytical Chemistry , University of Szeged , D�m
t�r 7 , Szeged H-6720 , Hungary.
AU - Kele Z
AD - Department of Medical Chemistry , University of Szeged , D�m t�r 8 , Szeged
H-6720 , Hungary.
AU - Jancs� A
AD - Department of Inorganic and Analytical Chemistry , University of Szeged , D�m
t�r 7 , Szeged H-6720 , Hungary.
SO - Inorg Chem. 2018, Jun 18; 57(12):7191-7200. [Inorganic chemistry]
AB - British anti-Lewisite (2,3-dimerkaptopropan-1-ol, dimercaprol, BAL) is one
of the best-known chelator-type therapeutic agents against toxic metal
ions and metalloids, especially arsenicals. Surprisingly, the mechanisms
of action at the molecular level, as well as the coordination features of
this traditional drug toward various arsenicals, are still poorly
revealed. The present study on the interaction of arsenous acid (H3AsO3)
with BAL, involving UV and NMR titrations, electrospray ionization mass
spectrometry, and 2D NMR experiments combined with MP2 calculations,
demonstrates that the reaction of H3AsO3 with BAL at pH = 7.0 results in a
more complex speciation than was assumed before. The three reactive
hydroxyl groups of H3AsO3 allow for interaction with three thiol moieties
via condensation reaction, leading to the observed AsBAL2 and As2BAL3
complexes besides the AsBAL species. This indicates the strong propensity
of inorganic As(III) to saturate its coordination sphere with thiolate
groups. The alcoholic hydroxyl group of the ligand may also directly bind
to As(III) in AsBAL. Compared to dithiothreitol or dithioeritritol, the
preference of BAL to form complexes with such a tridentate binding mode is
much lower owing to the more strained bridged bicyclic structure with an
&alpha;AsSC < 90&deg; bond angle and an unfavorable condensed boat-type
six-membered ring. On the basis of the NMR data, the predominating,
bidentately bound AsBAL species, including a five-membered chelate ring,
exists in rapidly interconverting envelope forms of E and Z stereoisomers.
The conditional stability constants calculated for the three macrospecies
from a series of UV data [log &beta;pH=7.0 = 6.95 (AsBAL), 11.56 (AsBAL2),
and 22.73 (As2BAL3)] reflect that BAL is still the most efficient, known,
dithiol-type chelator of H3AsO3.
LA - eng
IS - 1520-510X (Electronic)
PT - Journal Article
TA - Inorg Chem
YR - 2018
DATE- 20180618
CITO- NLM
CS - United States
FJT - Inorganic chemistry
EDAT- 20180601
STAT- In-Process
DOCNO- medline/29856616

365 - TOXLINE
TI - Toxic Effect of Cadmium, Lead, and Arsenic on the Sertoli Cell: Mechanisms
of Damage Involved.
AU - Ramos-Trevi�o J
AD - 1 Department of Reproductive Biology, Biomedical Research Center, Faculty of
Medicine, Autonomous University of Coahuila (UAdeC) , Torre�n, Coahuila, Mexico .
AU - Bassol-Mayagoitia S
AD - 1 Department of Reproductive Biology, Biomedical Research Center, Faculty of
Medicine, Autonomous University of Coahuila (UAdeC) , Torre�n, Coahuila, Mexico .
AU - Hern�ndez-Ibarra JA
AD - 1 Department of Reproductive Biology, Biomedical Research Center, Faculty of
Medicine, Autonomous University of Coahuila (UAdeC) , Torre�n, Coahuila, Mexico .
AU - Ruiz-Flores P
AD - 2 Department of Genetics and Molecular Medicine, Biomedical Research Center,
Faculty of Medicine, Autonomous University of Coahuila (UAdeC) , Torre�n, Coahuila,
Mexico .
AU - Nava-Hern�ndez MP
AD - 1 Department of Reproductive Biology, Biomedical Research Center, Faculty of
Medicine, Autonomous University of Coahuila (UAdeC) , Torre�n, Coahuila, Mexico .
SO - DNA Cell Biol. 2018, May 10. [DNA and cell biology]
AB - Over the past decades, an increase has been described in exposure to
environmental toxins; consequently, a series of studies has been carried
out with the aim of identifying problems associated with health. One of
the main risk factors is exposure to heavy metals. The adverse effects
that these compounds exert on health are quite complex and difficult to
elucidate, in that they act at different levels and there are various
signaling pathways that are implicated in the mechanisms of damage. The
Sertoli cells plays a role of vital importance during the process of
spermatogenesis, and it has been identified as one of the principal
targets of heavy metals. In the present review, cadmium, lead, and arsenic
are broached as altering the physiology of the Sertoli cells, citing
mechanisms that have been cited in the literature.
KW - Sertoli cells
KW - heavy metals
KW - signaling pathways
LA - eng
IS - 1557-7430 (Electronic)
PT - Journal Article
TA - DNA Cell Biol
YR - 2018
DATE- 20180510
CITO- NLM
CS - United States
FJT - DNA and cell biology
EDAT- 20180510
STAT- Publisher
DOCNO- medline/29746152

366 - TOXLINE
TI - Analysis and probabilistic risk assessment of bioaccessible arsenic in
polished and husked jasmine rice sold in Bangkok.
AU - Hensawang S
AD - Hazardous Substance and Environmental Management (Interdisciplinary Program),
Graduate School, Chulalongkorn University, Bangkok 10330, Thailand.
AU - Chanpiwat P
AD - Environmental Research Institute, Chulalongkorn University, Phayathai Road,
Pathumwan, Bangkok 10330, Thailand; Center of Excellence on Hazardous Substance
Management (HSM), Phayathai Road, Pathumwan, Bangkok 10330, Thailand. Electronic
address: Penradee.C@chula.ac.th.
SO - Chemosphere. 2018, Sep; 207:637-648. [Chemosphere]
AB - Food is one of the major sources of arsenic (As) exposure in humans. The
objectives of this study were to determine the bioaccessible concentration
of As in rice grain sold in Bangkok and to evaluate the potential health
risks associated with rice consumption. Polished (n&#8239;=&#8239;32) and
husked (n&#8239;=&#8239;17) jasmine rice were collected from local
markets. In vitro digestion was performed to determine the
bioaccessible As concentrations, which were used for probabilistic health
risk assessments in different age groups of the population. Approximately
43.0% and 44.4% of the total As in the grain of polished and husked rice,
respectively, was in the form of bioaccessible As. Significantly higher
bioaccessible As concentrations were found in husked rice than in polished
rice (1.5-3.8 times greater). The concentrations of bioaccessible As in
polished and husked rice were lower than the Codex standard for As in
rice. The average daily dose of As via rice consumption is equivalent to
the daily ingestion of 2&#8239;L of water containing approximately
3.2-7.2&#8239;&mu;g&#8239;L-1 of As. Approximately 0.2%-13.7% and
10.7%-55.3% of the population may experience non-carcinogenic effects from
polished and husked rice consumption, respectively. Approximately 1%-11.6%
of children and 74.1%-99.8% of adults were at risk of cancer. The maximum
cancer probabilities were 3 children and 6 adults in 10,000 individuals.
The probabilistic risk results indicated that children and adults were at
risk of both non-carcinogenic and carcinogenic effects from both types of
rice consumption.
KW - Bioavailable
KW - Daily exposure
KW - Human digestive system
KW - Market-based study
KW - Probabilistic risk
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180612
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20180522
STAT- In-Process
DOCNO- medline/29852463
367 - TOXLINE
TI - Change in metals and arsenic distribution in soil and their
bioavailability beside old tailing ponds.
AU - Gabarr�n M
AD - Sustainable Use, Management and Reclamation of Soil and Water Research Group,
Universidad Polit�cnica de Cartagena, Paseo Alfonso XIII 48, 30203, Cartagena,
Spain.
AU - Faz A
AD - Sustainable Use, Management and Reclamation of Soil and Water Research Group,
Universidad Polit�cnica de Cartagena, Paseo Alfonso XIII 48, 30203, Cartagena,
Spain.
AU - Mart�nez-Mart�nez S
AD - Sustainable Use, Management and Reclamation of Soil and Water Research Group,
Universidad Polit�cnica de Cartagena, Paseo Alfonso XIII 48, 30203, Cartagena,
Spain.
AU - Acosta JA
AD - Sustainable Use, Management and Reclamation of Soil and Water Research Group,
Universidad Polit�cnica de Cartagena, Paseo Alfonso XIII 48, 30203, Cartagena,
Spain. Electronic address: ja.acosta@upct.es.
SO - J Environ Manage. 2018, Apr 15; 212:292-300. [Journal of environmental
management]
AB - The objectives of this study were to determine the metals and arsenic
transfer from mining ponds to agricultural and forest soils, and identify
the dynamic of metal(loid)s in the soil-plant system for a native plant
species (Ballota hirsuta) in two old mining districts: La Uni�n and
Mazarr�n (Spain). Soils and plants from mining ponds and natural
and agricultural areas were collected and analyzed for soil properties,
and chemical partitioning of Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Zn and As.
Results showed that mine, forest and agricultural soils were contaminated
by As, Cd, Cu, Pb, and Zn. Chemical partitioning revealed higher mobility
of metals in mining ponds than natural and agricultural soils except for
Fe and As which were mostly bound to soil matrix due to the mineralogical
compositions of soils. The accumulation of metal(loid)s in B. hirsuta
in La Uni�n decreased as
Fe&#8239; > &#8239;As&#8239; > &#8239;Cr&#8239; >
Ni&#8239; > &#8239;Cu&#8239; > &#8239;Zn&#8239; >
Cd&#8239; > &#8239;Mn&#8239; > &#8239;Co&#8239; > &#8239;Pb while in
Mazarr�n was
As&#8239; > &#8239;Fe&#8239; > &#8239;Cr&#8239; > &#8239;Pb&#8239; >
&#8239;Cu&#8239; > &#8239;Ni&#8239; > &#8239;Co&#8239; > &#8239;Mn&#8239; >
&#8239;Zn&#8239; > &#8239;Cd,
showing that B. hirsuta has high ability to bio-accumulate Fe, As,
Cr, Cu and Ni; and Pb (in Mazarr�n), transferring a significant
concentration of theses metal(loid)s, except Pb, to edible parts without
exceeding the toxicity limits for animals. Therefore, B. hirsuta
could be useful as phytoextractor species for Cr, Cu, As and Ni, while it
can be used as phytostabilizer species for Zn, Co, Pb and Cd.
KW - Ballota hirsuta
KW - Bioaccumulation
KW - Chemical partitioning
KW - Mining pond
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180222
STAT- In-Process
DOCNO- medline/29448183

368 - TOXLINE
TI - The influence of Arsenic on the toxicity of carbon nanoparticles in
bivalves.
AU - Freitas R
AD - Department of Biology &amp; Center for Environmental and Marine Studies
(CESAM), University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address:
rosafreitas@ua.pt.
AU - Coppola F
AD - Department of Biology &amp; Center for Environmental and Marine Studies
(CESAM), University of Aveiro, 3810-193, Aveiro, Portugal.
AU - De Marchi L
AD - Department of Biology &amp; Center for Environmental and Marine Studies
(CESAM), University of Aveiro, 3810-193, Aveiro, Portugal.
AU - Codella V
AD - Department of Biology &amp; Center for Environmental and Marine Studies
(CESAM), University of Aveiro, 3810-193, Aveiro, Portugal.
AU - Pretti C
AD - Department of Veterinary Sciences, University of Pisa, San Piero a Grado,
Pisa, 56122, Italy.
AU - Chiellini F
AD - Department of Chemistry and Industrial Chemistry, University of Pisa, Udr
INSTM Pisa, Pisa, 56126, Italy.
AU - Morelli A
AD - Department of Chemistry and Industrial Chemistry, University of Pisa, Udr
INSTM Pisa, Pisa, 56126, Italy.
AU - Polese G
AD - Department of Biology, University of Napoli Federico II, 80126, Napoli,
Italy.
AU - Soares AMVM
AD - Department of Biology &amp; Center for Environmental and Marine Studies
(CESAM), University of Aveiro, 3810-193, Aveiro, Portugal.
AU - Figueira E
AD - Department of Biology &amp; Center for Environmental and Marine Studies
(CESAM), University of Aveiro, 3810-193, Aveiro, Portugal.
SO - J Hazard Mater. 2018, Jun 02. [Journal of hazardous materials]
AB - Although an increasing number of studies have been published on the
effects of emergent pollutants such as carbon nanoparticles, there is
still scarce information on the impact of these contaminants on marine
organisms when acting in combination with classical pollutants such as
meta(loid)s. The present study evaluated the impacts of Arsenic and
Multi-Walled Carbon Nanotubes (MWCNTs) in the clam Ruditapes
philippinarum, assessing the effects induced when both contaminants were
acting individually (As, NP) and as a mixture (As&#8239;+&#8239;NP).
Metabolic capacity (electron transport system activity), oxidative stress
(antioxidant and biotransformation enzymes activity and cellular damage)
and neurotoxicity (Acetylcholinesterase activity) biomarkers were
evaluated in clams after a 28 days exposure period. The results obtained
showed that the accumulation of As was not affected by the presence of the
NPs. Our results demonstrated that higher injuries were noticed in clams
exposed to NPs, with higher metabolic depression and oxidative stress,
regardless of the presence of As. Furthermore, higher neurotoxicity was
observed in clams exposed to the combination of both contaminants in
comparison to the effects of As and NPs individually.
KW - Functionalized multi-walled carbon nanotubes
KW - Metabolism
KW - Mixture of contaminants
KW - Neurotoxicity
KW - Oxidative stress
KW - Ruditapes philippinarum
LA - eng
IS - 1873-3336 (Electronic)
PT - Journal Article
TA - J Hazard Mater
YR - 2018
DATE- 20180617
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of hazardous materials
EDAT- 20180602
STAT- Publisher
DOCNO- medline/29908840

369 - TOXLINE
TI - Antimony-Induced Neurobehavioral and Biochemical Perturbations in Mice.
AU - Tanu T
AD - Department of Biochemistry and Molecular Biology, University of Rajshahi,
Rajshahi, 6205, Bangladesh.
AU - Anjum A
AD - Department of Biochemistry and Molecular Biology, University of Rajshahi,
Rajshahi, 6205, Bangladesh.
AU - Jahan M
AD - Department of Biochemistry and Molecular Biology, University of Rajshahi,
Rajshahi, 6205, Bangladesh.
AU - Nikkon F
AD - Department of Biochemistry and Molecular Biology, University of Rajshahi,
Rajshahi, 6205, Bangladesh.
AU - Hoque M
AD - Department of Biochemistry and Molecular Biology, University of Rajshahi,
Rajshahi, 6205, Bangladesh.
AU - Roy AK
AD - Department of Genetic Engineering and Biotechnology, University of Rajshahi,
Rajshahi, 6205, Bangladesh.
AU - Haque A
AD - Department of Microbiology and Immunology, Medical University of South
Carolina, Charleston, SC, 29425, USA.
AU - Himeno S
AD - Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical
Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan.
AU - Hossain K
AD - Department of Biochemistry and Molecular Biology, University of Rajshahi,
Rajshahi, 6205, Bangladesh.
AU - Saud ZA
AD - Department of Biochemistry and Molecular Biology, University of Rajshahi,
Rajshahi, 6205, Bangladesh. zasaud@ru.ac.bd.
SO - Biol Trace Elem Res. 2018, Mar 08. [Biological trace element research]
AB - Groundwater used for drinking has been contaminated with naturally
occurring inorganic arsenic and other metals, and metal-contaminated
drinking water is the biggest threat to public health in Bangladesh. Toxic
metals present in the drinking water have a strong relationship with
chronic diseases in humans. Antimony (Sb), a naturally occurring metal,
has been reported to be present in the drinking water along with other
heavy metals in Bangladesh. Although Sb is present in the environment,
very little attention has been given to the toxic effects of Sb. The
present study was designed to investigate the in vivo effects of Sb on
neurobehavioral changes like anxiety, learning and memory impairment, and
blood indices related to organ dysfunction. Mice exposed to antimony
potassium-tartrate hydrate (Sb) (10 mg/kg body weight) significantly
(p&thinsp; < &thinsp;0.05) decreased the time spent in open arms while
increased the time spent in closed arms compared to the control mice in
elevated plus maze. The mean latency time of control group to find the
platform decreased (p&thinsp; < &thinsp;0.05) significantly during
7 days learning as compared to Sb-treated group in Morris water maze
test, and Sb-exposed group spent significantly (p&thinsp; < &thinsp;0.05)
less time in the desired quadrant as compared to the control group in
probe trial. Sb treatment also significantly altered blood indices related
to liver and kidney dysfunction. Additionally, Sb-induced biochemical
alterations were associated with significant perturbations in histological
architecture of liver and kidney of Sb-exposed mice. These data suggest
that Sb has a toxic effect on neurobehavioral and biochemical changes in
mice.
KW - Antimony
KW - Anxiety
KW - Groundwater
KW - Learning
KW - Spatial memory
KW - Toxicity
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180309
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180308
STAT- Publisher
DOCNO- medline/29520725

370 - TOXLINE
TI - Genotoxicity evaluation of multi-component mixtures of polyaromatic
hydrocarbons (PAHs), arsenic, cadmium, and lead using flow cytometry based
micronucleus test in HepG2 cells.
AU - Muthusamy S
AD - The University of Queensland, National Research Centre for Environmental
Toxicology (Entox), Member of Queensland Alliance for Environmental Health Science
(QAEHS), Coopers Plains, Brisbane, QLD, 4108, Australia; CRC CARE, The University
of Newcastle, University Drive, Callaghan, NSW, 2308, Australia.
AU - Peng C
AD - The University of Queensland, National Research Centre for Environmental
Toxicology (Entox), Member of Queensland Alliance for Environmental Health Science
(QAEHS), Coopers Plains, Brisbane, QLD, 4108, Australia; CRC CARE, The University
of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. Electronic
address: c.peng@uq.edu.au.
AU - Ng JC
AD - The University of Queensland, National Research Centre for Environmental
Toxicology (Entox), Member of Queensland Alliance for Environmental Health Science
(QAEHS), Coopers Plains, Brisbane, QLD, 4108, Australia; CRC CARE, The University
of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. Electronic
address: j.ng@uq.edu.au.
SO - Mutat Res. 2018, Mar; 827:9-18. [Mutation research]
AB - Some polyaromatic hydrocarbons (PAHs) and metals are known human
carcinogens and the combined toxicity data of these co-contaminants are
important for assessing their health risk. In this study, we have
evaluated the combined genotoxicity, AhR activity and cell cycle
parameters of four PAHs (benzo[a]pyrene (Ba]P), naphthalene (Nap),
phenanthrene (Phe) and pyrene (Pyr)) and three metals (arsenic (As),
cadmium (Cd), and lead (Pb)) in HepG2 cells using a flow cytometry based
micronucleus (MN) test CAFLUX assay and nuclear fluorescence assay,
respectively. The mixtures of B[a]P and metals induced a maximum of four
fold increase in the MN formation compared to B[a]P alone. The higher
combination of PAHs and metals did not significantly increase the MN
formation. The mixtures of metals or non-carcinogenic PAHs were found to
increase or decrease the aryl hydrocarbon receptor (AhR) activation of
B[a]P in HepG2 cell based CAFLUX assay. Overall, the results showed that
combined genotoxicity of PAHs and metals in HepG2 cells vary depending on
the concentrations and number of the chemicals that are present in the
mixtures and the effects of higher order combinations appear to be largely
unpredictable from binary combinations. In this study, we have
demonstrated the use of flow cytometry based MN test to screen the
genotoxicity of environmental chemicals and its mixtures.
KW - AhR
KW - Cell cycle
KW - Chemical mixtures
KW - Co-genotoxicity
KW - Flow cytometry
KW - In-vitro micronucleus test
KW - PAHs and metals
LA - eng
IS - 1873-135X (Electronic)
PT - Journal Article
TA - Mutat Res
YR - 2018
DATE- 20180305
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Mutation research
EDAT- 20180110
STAT- In-Data-Review
DOCNO- medline/29502740

371 - TOXLINE
TI - Aromatic organoarsenic compounds (AOCs) occurrence and remediation
methods.
AU - Fei J
AD - School of Metallurgy and Environment, Central South University, Changsha,
410083, China.
AU - Wang T
AD - College of Resources and Environment, Hunan Agricultural University, Changsha
410128, China.
AU - Zhou Y
AD - College of Resources and Environment, Hunan Agricultural University, Changsha
410128, China. Electronic address: zhouyy@hunau.edu.cn.
AU - Wang Z
AD - South China Institute of Environmental Sciences, Ministry of Environmental
Protection, Guangzhou 510655, China.
AU - Min X
AD - School of Metallurgy and Environment, Central South University, Changsha,
410083, China. Electronic address: mxbcsu@163.com.
AU - Ke Y
AD - School of Metallurgy and Environment, Central South University, Changsha,
410083, China.
AU - Hu W
AD - School of Metallurgy and Environment, Central South University, Changsha,
410083, China.
AU - Chai L
AD - School of Metallurgy and Environment, Central South University, Changsha,
410083, China.
SO - Chemosphere. 2018, Sep; 207:665-675. [Chemosphere]
AB - Many researchers at home and abroad have made a body of researches and
have gained great achievements on the environmental occurrence, fate, and
toxicity of inorganic arsenic. But there is less research on the use of
aromatic organoarsenic compounds (AOCs), which are common feed additives
for livestock in the poultry industry. In this review, we outline the
current state of knowledge acquired on the occurrence and remediation of
AOCs, respectively. We also identify knowledge gaps and research needs,
including the elucidation of the environmental fate of AOCs, metabolic
pathway, the impact of metabolic modification on toxicity, and advanced
analytical or repaired methods that allows for monitoring, identification
or removal of the degradation products.
KW - Occurrence
KW - Organoarsenic compounds
KW - Remediation
KW - Roxarsone
KW - p-Arsanilic acid
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
PT - Review
TA - Chemosphere
YR - 2018
DATE- 20180612
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20180524
STAT- In-Process
DOCNO- medline/29857198

372 - TOXLINE
TI - Systematic review and health risk assessment of arsenic and lead in the
fished shrimps from the Persian gulf.
AU - Fakhri Y
AD - Department of Environmental Health Engineering, Student Research Committee,
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran,
Iran. Electronic address: Ya.fakhri@gmail.com.
AU - Mohseni-Bandpei A
AD - Environmental and Occupational Hazards Control Research Center, Shahid
Beheshti University of Medical Sciences, Tehran, Iran.
AU - Oliveri Conti G
AD - Environmental and Food Hygiene Laboratories (LIAA), 'G.F. Ingrassia'
Department, Hygiene and Public Health, University of Catania, Catania, Italy.
AU - Ferrante M
AD - Environmental and Food Hygiene Laboratories (LIAA), 'G.F. Ingrassia'
Department, Hygiene and Public Health, University of Catania, Catania, Italy.
AU - Cristaldi A
AD - Environmental and Food Hygiene Laboratories (LIAA), 'G.F. Ingrassia'
Department, Hygiene and Public Health, University of Catania, Catania, Italy.
AU - Jeihooni AK
AD - Department of Public Health, Fasa University of Medical Sciences, Fasa, Iran.
AU - Karimi Dehkordi M
AD - Department of Clinical Pathology, Faculty of Veterinary Medicine, Shahrekord
Branch, Islamic Azad University, Shahrekord, Iran.
AU - Alinejad A
AD - Department of Public Health, Fasa University of Medical Sciences, Fasa, Iran.
AU - Rasoulzadeh H
AD - Department of Environmental Health Engineering, Student Research Committee,
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran,
Iran; Environmental and Occupational Hazards Control Research Center, Shahid
Beheshti University of Medical Sciences, Tehran, Iran.
AU - Mohseni SM
AD - Department of Environmental Health Engineering, School of Public Health, Qom
University of Medical Sciences, Qom, Iran.
AU - Sarkhosh M
AD - Department of Environmental Health Engineering, School of Health, Mashhad
University of Medical Sciences, Mashhad, Iran.
AU - Keramati H
AD - Department of Environmental Health Engineering, School of Public Health,
Semnan University of Medical Sciences, Semnan, Iran.
AU - Moradi B
AD - Department of Health Public, Kermanshah University of Medical Sciences,
Kermanshah, Iran.
AU - Amanidaz N
AD - Environmental Health Research Center, Golestan University of Medical
Sciences, Golestan, Iran.
AU - Baninameh Z
AD - Sina Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
SO - Food Chem Toxicol. 2018, Mar; 113:278-286. [Food and chemical toxicology :
an international journal published for the British Industrial Biological
Research Association]
AB - The ingestion of heavy metals through contaminated seafood can causes
significant outcomes on human health. In recent years, consume fishes and
shrimps has increased in Iran, and several study about heavy metals
content in fishes and shrimps from Persian Gulf were carried out to check
their food safety. The aims of these systematic reviews and meta-analysis
was to summarize the evidence on the relation of the intakes of Arsenic
(As) and lead (Pb) levels, based on the origin and sub-groups of shrimp
species consumed, Hence that we can estimate the risk of oral cancer
induced by Pb and As in these groups of shrimp from the persian gulf. We
carried out a search of all suitable studies published between 1995 and
2017 in Scopus, Science Direct, PubMed and Web of Science databases. Since
the heterogeneity among studied was significant, we used the random effect
model (REM) to perform meta-analysis of data. Data were obtained from 9
articles (14 studies), with 511 samples, and it was reported that pooled
levels of As and Pb in the muscle shrimps were 1.37 (95% CI:
0.66-2.08&#8239;mg/kg d.w.) and 0.58 (95% CI: 0.33-0.82&#8239;mg/kg d.w.),
respectively. This pooled levels in muscle shrimps were higher than safe
dose reported on Food and Agriculture Organization/World Health
Organization guidelines (FAO/WHO). The rank order of shrimps species based
on As was Panulirus homarus&#8239; > &#8239;Penaeus semisulcatus and for
the Pb levels was Litopenaeus vannamei&#8239; > &#8239;Panulirus
homarus&#8239; > &#8239;Fenneropenaeus
indicus&#8239; > &#8239;Metapenaeus affinis. The lowest and highest risk
levels of oral cancer, divided by consumers age groups, were respectively
45-54 (6.94E-04) and 15-24 (8.42E-04) for the Pb, and 45-54 (2.87E-01) and
15-24 (3.51E-01) for arsenic. Incremental Lifetime Cancer Risk (ILCR) of
Pb and As was higher than 10-4 and 10-3, respectively. All groups (age) of
consumers are subject to the cancer risk of due to the consumption of
shrimps contaminated by Pb and As, therefore, should be started a control
plan for the reduction of the heavy metal bioaccumulation levels in
shrimps of the Persian Gulf coupled to a capillary food safety
communication.
KW - As
KW - Bioconcentration
KW - Carcinogenic risk
KW - Food safety
KW - Pb
KW - Risk assessment
KW - Shrimps
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180228
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180131
STAT- In-Process
DOCNO- medline/29407475

373 - TOXLINE
TI - Prevalence of exposure of heavy metals and their impact on health
consequences.
AU - Rehman K
AD - Institute of Pharmacy, Physiology, and Pharmacology, University of
Agriculture, Faisalabad, Pakistan.
AU - Fatima F
AD - Institute of Pharmacy, Physiology, and Pharmacology, University of
Agriculture, Faisalabad, Pakistan.
AU - Waheed I
AD - Institute of Pharmacy, Physiology, and Pharmacology, University of
Agriculture, Faisalabad, Pakistan.
AU - Akash MSH
AD - Department of Pharmaceutical Chemistry, Government College University
Faisalabad, Faisalabad, Pakistan.
SO - J Cell Biochem. 2018, 01; 119(1):157-184. [Journal of cellular
biochemistry]
AB - Even in the current era of growing technology, the concentration of heavy
metals present in drinking water is still not within the recommended
limits as set by the regulatory authorities in different countries of the
world. Drinking water contaminated with heavy metals namely; arsenic,
cadmium, nickel, mercury, chromium, zinc, and lead is becoming a major
health concern for public and health care professionals. Occupational
exposure to heavy metals is known to occur by the utilization of these
metals in various industrial processes and/or contents including color
pigments and alloys. However, the predominant source resulting in
measurable human exposure to heavy metals is the consumption of
contaminated drinking water and the resulting health issues may include
cardiovascular disorders, neuronal damage, renal injuries, and risk of
cancer and diabetes. The general mechanism involved in heavy metal-induced
toxicity is recognized to be the production of reactive oxygen species
resulting oxidative damage and health related adverse effects. Thus
utilization of heavy metal-contaminated water is resulting in high
morbidity and mortality rates all over the world. Thereby, feeling the
need to raise the concerns about contribution of different heavy metals in
various health related issues, this article has discussed the global
contamination of drinking water with heavy metals to assess the health
hazards associated with consumption of heavy metal-contaminated water. A
relationship between exposure limits and ultimate responses produced as
well as the major organs affected have been reviewed. Acute and chronic
poisoning symptoms and mechanisms responsible for such toxicities have
also been discussed.
KW - *cancer
KW - *diabetes mellitus
KW - *heavy metals
KW - *oxidative stress
KW - *reactive oxygen species
RN - 00BH33GNGH
RN - 2P299V784P
RN - 7OV03QG267
RN - N712M78A8G
LA - eng
IS - 1097-4644 (Electronic)
PT - Journal Article
PT - Review
PT - Research Support, Non-U.S. Gov't
TA - J Cell Biochem
YR - 2018
DATE- 20180613
CI - &copy; 2017 Wiley Periodicals, Inc.
CITO- NLM
CS - United States
CSET- IM
FJT - Journal of cellular biochemistry
EDAT- 20170802
STAT- MEDLINE
DOCNO- medline/28643849

374 - TOXLINE
TI - Comparative sensitivity of Crassostrea angulata and Crassostrea gigas
embryo-larval development to As under varying salinity and temperature.
AU - Moreira A
AD - Department of Biology &amp; CESAM, University of Aveiro, Campus Universit�rio
de Santiago, Aveiro, Portugal.
AU - Figueira E
AD - Department of Biology &amp; CESAM, University of Aveiro, Campus Universit�rio
de Santiago, Aveiro, Portugal.
AU - Libralato G
AD - Department of Biology, University of Naples Federico II, via Cinthia ed. 7,
80126, Naples, Italy.
AU - Soares AMVM
AD - Department of Biology &amp; CESAM, University of Aveiro, Campus Universit�rio
de Santiago, Aveiro, Portugal.
AU - Guida M
AD - Department of Biology, University of Naples Federico II, via Cinthia ed. 7,
80126, Naples, Italy.
AU - Freitas R
AD - Department of Biology &amp; CESAM, University of Aveiro, Campus Universit�rio
de Santiago, Aveiro, Portugal. Electronic address: rosafreitas@ua.pt.
SO - Mar Environ Res. 2018, Jun 07. [Marine environmental research]
AB - Oysters are a diverse group of marine bivalves that inhabit coastal
systems of the world's oceans, providing a variety of ecosystem services,
and represent a major socioeconomic resource. However, oyster reefs have
become inevitably impacted from habitat destruction, overfishing,
pollution and disease outbreaks that have pushed these structures to the
break of extinction. In addition, the increased frequency of climate
change related events promise to further challenge oyster species survival
worldwide. Oysters' early embryonic development is likely the most
vulnerable stage to climate change related stressors (e.g. salinity and
temperature shifts) as well as to pollutants (e.g. arsenic), and therefore
can represent the most important bottleneck that define populations'
survival in a changing environment. In light of this, the present study
aimed to assess two important oyster species, Crassostrea angulata and
Crassostrea gigas embryo-larval development, under combinations of
salinity (20, 26 and 33), temperature (20, 24 and 28&#8239;&deg;C) and
arsenic (As) exposure (0, 30, 60, 120, 240, 480, 960 and 1920&#8239;&mu;g.
As L-1), to infer on different oyster species capacity to cope with these
environmental stressors under the eminent threat of climate change and
increase of pollution worldwide. Results showed differences in each
species range of salinity and temperature for successful embryonic
development. For C angulata, embryo-larval development was successful at a
narrower range of both salinity and temperature, compared to C. gigas.
Overall, As induced higher toxicity to C. angulata embryos, with
calculated EC50 values at least an order of magnitude lower than those
calculated for C. gigas. The toxicity of As (measured as median effective
concentration, EC50) showed to be influenced by both salinity and
temperature in both species. Nonetheless, salinity had a greater influence
on embryos' sensitivity to As. This pattern was mostly noticed for C.
gigas, with lower salinity inducing higher sensitivity to As. Results were
discussed considering the existing literature and suggest that C. angulata
populations are likely to become more vulnerable under near future
predictions for temperature rise, salinity shifts and pollution.
KW - Arsenic
KW - Climate change
KW - Development
KW - Embryotoxicity
KW - Oyster
KW - Thermohaline
LA - eng
IS - 1879-0291 (Electronic)
PT - Journal Article
TA - Mar Environ Res
YR - 2018
DATE- 20180618
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Marine environmental research
EDAT- 20180607
STAT- Publisher
DOCNO- medline/29910029

375 - TOXLINE
TI - Unraveling mechanisms of toxicant-induced oxidative stress in
cardiovascular disease.
AU - Dugas TR
AD - Department of Comparative Biomedical Sciences, LSU School of Veterinary
Medicine, Skip Bertman Drive, Baton Rouge, LA 70803.
SO - Curr Opin Toxicol. 2018, Feb; 7:1-8. [Current opinion in toxicology]
AB - To date, numerous clinical studies examining correlations between
oxidative stress biomarkers and cardiovascular diseases (CVD) have
repeatedly suggested a role for oxidant injury in the pathogenesis of
diseases such as atherosclerosis. Despite this, antioxidant
supplementation trials have not demonstrated a reduction in disease
progression. Nevertheless, small animal and epidemiological studies have
linked exposures to certain toxicants with increased CVD risk involving
putative oxidative stress mechanisms. A few prototypical vascular
toxicants will be discussed as examples of toxicants that likely act via
oxidative stress mechanisms. For discussion, we will classify these
toxicants as those that induce direct (e.g., arsenic, nucleoside reverse
transcriptase inhibitors) versus indirect (particulate matter, ozone)
oxidative stress mechanisms, and those that likely induce CVD through both
direct and indirect mechanisms (cigarette smoke). Finally, new findings in
oxidative stress research, including the emerging importance of reactive
sulfur species, hydrogen peroxide as a presumed endothelium-derived
hyperpolarizing factors, etc., will be discussed, as well as the need to
determine the role of toxicants in modulating these newly identified
pathways. Moreover, given the lack of success in conclusively
demonstrating the roles of oxidative stress in CVD risk stratification,
research probing the roles of toxicant exposures in propagating CVD
pathogenesis may be a novel approach for more conclusively delineating the
causal role of oxidative stress in CVD initiation and progression.
KW - arsenic
KW - atherosclerosis
KW - cardiovascular
KW - cigarette smoke
KW - endothelial dysfunction
KW - oxidative stress
KW - ozone
KW - particulate matter
LA - eng
IS - 2468-2934 (Print)
PT - Journal Article
TA - Curr Opin Toxicol
YR - 2018
DATE- 20180213
CITO- NLM
CS - Netherlands
FJT - Current opinion in toxicology
EDAT- 20171012
STAT- PubMed-not-MEDLINE
CM - Cites: Toxicol Appl Pharmacol. 2008 Jan 1;226(1):94-106 (medline
/17904600)
CM - Cites: AIDS. 2000 Feb 18;14(3):F25-32 (medline /10716495)
CM - Cites: N Engl J Med. 1995 May 4;332(18):1198-203 (medline /7700313)
CM - Cites: Cardiovasc Toxicol. 2010 Sep;10(3):227-38 (medline /20694523)
CM - Cites: AIDS. 1998 May 7;12(7):F51-8 (medline /9619798)
CM - Cites: Methods Enzymol. 2013;528:129-54 (medline /23849863)
CM - Cites: Int J Environ Res Public Health. 2016 Jun 08;13(6): (medline
/27338429)
CM - Cites: Environ Sci Technol. 2017 Jul 18;51(14 ):7936-7944 (medline
/28613843)
CM - Cites: Toxicol Sci. 2009 Feb;107(2):312-23 (medline /19015167)
CM - Cites: Free Radic Biol Med. 2002 Jun 1;32(11):1076-83 (medline /12031892)
CM - Cites: J Am Coll Cardiol. 2003 Oct 1;42(7):1149-60 (medline /14522472)
CM - Cites: Redox Biol. 2013 Oct 08;1:483-91 (medline /24251116)
CM - Cites: J Air Waste Manag Assoc. 2006 Jun;56(6):709-42 (medline /16805397)
CM - Cites: BMJ. 2014 Jan 21;348:f7412 (medline /24452269)
CM - Cites: Clin Cardiol. 1997 May;20(5):426-32 (medline /9134272)
CM - Cites: Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1586-97 (medline
/19270193)
CM - Cites: J Pharmacol Exp Ther. 2015 Jun;353(3):458-64 (medline /25788710)
CM - Cites: Free Radic Biol Med. 2003 Jul 1;35(1):102-13 (medline /12826260)
CM - Cites: Arterioscler Thromb Vasc Biol. 2003 Feb 1;23(2):168-75 (medline
/12588755)
CM - Cites: Arterioscler Thromb Vasc Biol. 2003 Mar 1;23(3):434-9 (medline
/12615693)
CM - Cites: AIDS. 1999 Dec 24;13(18):2493-505 (medline /10630518)
CM - Cites: Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1485-91 (medline
/15217803)
CM - Cites: J Recept Signal Transduct Res. 2011 Apr;31(2):157-67 (medline
/21385100)
CM - Cites: Toxicol Lett. 2015 Jan 22;232(2):422-8 (medline /25482063)
CM - Cites: Int J Cancer. 2016 Sep 15;139(6):1261-9 (medline /27163125)
CM - Cites: J Am Coll Cardiol. 2006 Jun 6;47(11):2212-8 (medline /16750686)
CM - Cites: Redox Biol. 2017 Aug;12 :325-339 (medline /28285261)
CM - Cites: Circulation. 1998 Apr 28;97(16):1536-9 (medline /9593557)
CM - Cites: Toxicol Sci. 2010 Oct;117(2):537-46 (medline /20634294)
CM - Cites: Handb Exp Pharmacol. 2015 ;230:29-59 (medline /26162828)
CM - Cites: Free Radic Res. 2005 Oct;39(10):1071-81 (medline /16298732)
CM - Cites: PLoS One. 2014 Feb 07;9(2):e88578 (medline /24516670)
CM - Cites: Circulation. 2002 Apr 2;105(13):1534-6 (medline /11927516)
CM - Cites: JAMA. 2008 May 7;299(17):2027-36 (medline /18460663)
CM - Cites: Free Radic Biol Med. 2002 Dec 1;33(11):1490-8 (medline /12446206)
CM - Cites: Antiviral Res. 2014 Nov;111:136-42 (medline /25260898)
CM - Cites: Circulation. 1999 Aug 17;100(7):700-5 (medline /10449690)
CM - Cites: Eur Heart J. 2008 Jan;29(2):224-30 (medline /18156137)
CM - Cites: Clin Chim Acta. 2008 Aug;394(1-2):59-62 (medline /18440308)
CM - Cites: Atherosclerosis. 2005 Mar;179(1):193-200 (medline /15721027)
CM - Cites: Circulation. 1998 Dec 22-29;98(25):2822-8 (medline /9860782)
CM - Cites: Coron Artery Dis. 2003 May;14(3):213-8 (medline /12702924)
CM - Cites: Environ Sci Technol. 2011 Oct 1;45(19):8559-66 (medline /21823585)
CM - Cites: Toxicol Lett. 1995 Dec;82-83:287-93 (medline /8597067)
CM - Cites: J Natl Cancer Inst. 2014 Oct 01;106(11):null (medline /25274579)
CM - Cites: Cardiovasc Toxicol. 2004;4(3):217-28 (medline /15470270)
CM - Cites: Mol Pharmacol. 2013 May;83(5):1133-40 (medline /23478803)
CM - Cites: Am J Respir Cell Mol Biol. 2013 Feb;48(2):188-97 (medline
/23087054)
CM - Cites: Int J Cancer. 2010 Oct 15;127(8):1875-81 (medline /20104528)
CM - Cites: Toxicol Appl Pharmacol. 2007 Oct 1;224(1):60-71 (medline /17669453)
CM - Cites: Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):295-307 (medline
/26715682)
CM - Cites: Arch Intern Med. 2004 Nov 22;164(21):2335-42 (medline /15557412)
CM - Cites: Environ Sci Technol. 2011 Aug 1;45(15):6356-65 (medline /21732664)
CM - Cites: J Hazard Mater. 2008 Aug 15;156(1-3):277-84 (medline /18249066)
CM - Cites: Intern Emerg Med. 2014 Mar;9(2):123-31 (medline /24057419)
CM - Cites: Br J Pharmacol. 2017 Apr 21;:null (medline /28430357)
CM - Cites: Toxicol Sci. 2013 Aug;134(2):304-11 (medline /23650127)
CM - Cites: Circulation. 2001 Jun 12;103(23):2810-5 (medline /11401937)
CM - Cites: JAMA. 2001 Nov 7;286(17):2136-42 (medline /11694155)
CM - Cites: Crit Rev Food Sci Nutr. 2015;55(14):1968-91 (medline /24941429)
CM - Cites: Circulation. 1997 Nov 18;96(10):3314-20 (medline /9396422)
CM - Cites: Arch Intern Med. 2007 Aug 13-27;167(15):1610-8 (medline /17698683)
CM - Cites: J Cardiovasc Pharmacol. 2008 Dec;52(6):510-7 (medline /19034034)
CM - Cites: Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1523-32 (medline
/16987008)
CM - Cites: Free Radic Biol Med. 2017 Aug;109 :4-10 (medline /27988339)
CM - Cites: JAMA. 2002 Nov 20;288(19):2432-40 (medline /12435256)
CM - Cites: Am J Physiol Lung Cell Mol Physiol. 2009 Aug;297(2):L209-16
(medline /19395667)
CM - Cites: Toxicol Appl Pharmacol. 2014 Oct 1;280(1):107-16 (medline
/25058445)
CM - Cites: Toxicol Sci. 2017 Mar 1;156(1):300-310 (medline /28115642)
CM - Cites: Chem Res Toxicol. 2013 Dec 16;26(12):1862-71 (medline /24224526)
CM - Cites: J Am Heart Assoc. 2016 Apr 28;5(5):null (medline /27126478)
CM - Cites: J Clin Invest. 1997 Oct 15;100(8):2028-34 (medline /9329967)
CM - Cites: Clin Chim Acta. 2012 Jan 18;413(1-2):25-9 (medline /22024218)
CM - Cites: Int J Vitam Nutr Res. 1998;68(1):3-20 (medline /9503043)
CM - Cites: Arch Intern Med. 2012 Feb 13;172(3):229-34 (medline /22332153)
CM - Cites: Chem Biol Interact. 2015 Jul 25;237:104-14 (medline /26079204)
CM - Cites: Free Radic Biol Med. 2001 Nov 1;31(9):1132-8 (medline /11677046)
CM - Cites: Toxicol Res. 2014 Sep;30(3):149-57 (medline /25343008)
CM - Cites: Biochemistry. 1998 Apr 21;37(16):5633-42 (medline /9548949)
CM - Cites: Nat Med. 1995 May;1(5):417-22 (medline /7585087)
CM - Cites: Circulation. 1999 Jan 19;99(2):224-9 (medline /9892587)
DOCNO- medline/29423456

376 - TOXLINE
TI - Comparative uptake study of arsenic, boron, copper, manganese and zinc
from water by different green microalgae.
AU - Saavedra R
AD - Department of Chemical Engineering and Environmental Technology, Valladolid
University, Dr. Mergelina, s/n, 47011 Valladolid, Spain; Department of Chemical
Engineering, Antofagasta University, Universidad de Antofagasta Avenue 02800, CP
1240000 Antofagasta, Chile.
AU - Mu�oz R
AD - Department of Chemical Engineering and Environmental Technology, Valladolid
University, Dr. Mergelina, s/n, 47011 Valladolid, Spain.
AU - Taboada ME
AD - Department of Chemical Engineering, Antofagasta University, Universidad de
Antofagasta Avenue 02800, CP 1240000 Antofagasta, Chile.
AU - Vega M
AD - Department of Analytical Chemistry, Valladolid University, Campus Miguel
Delibes, Paseo Bel�n 7, 47011 Valladolid, Spain.
AU - Bolado S
AD - Department of Chemical Engineering and Environmental Technology, Valladolid
University, Dr. Mergelina, s/n, 47011 Valladolid, Spain. Electronic address:
silvia@iq.uva.es.
SO - Bioresour Technol. 2018, Apr 26; 263:49-57. [Bioresource technology]
AB - This work represents a comparative uptake study of the toxic elements
arsenic, boron, copper, manganese and zinc in monometallic and
multimetallic solutions by four green microalgae species (Chlamydomonas
reinhardtii, Chlorella vulgaris, Scenedesmus almeriensis and an indigenous
Chlorophyceae spp.), evaluating the effect of pH and contact time. Maximum
removal efficiencies for each toxic element were 99.4% for Mn (C.
vulgaris, pH 7.0, 3&#8239;h), 91.9% for Zn (Chlorophyceae spp., pH 5.5,
3&#8239;h), 88% for Cu (Chlorophyceae spp., pH 7.0, 10&#8239;min), 40.7%
for As (S. almeriensis, pH 9.5, 3&#8239;h) and 38.6% for B (S.
almeriensis, pH 5.5, 10&#8239;min). B removal efficiencies decreased
remarkably in multimetallic solutions (down to 0.2% in C. reinhardtii),
except for Chlorophyceae spp., the only species isolated from a polluted
environment. FTIR spectra shown the highest interactions for As
(1150-1300&#8239;cm-1) and Cu (3300, 1741, 1535, 1350-1400&#8239;cm-1).
Results confirm microalgae biomass as a potential biosorbent for toxic
elements.
KW - Adsorption
KW - Bioremediation
KW - Heavy metals
KW - Microalgae
KW - Toxic elements
LA - eng
IS - 1873-2976 (Electronic)
PT - Journal Article
TA - Bioresour Technol
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Bioresource technology
EDAT- 20180426
STAT- Publisher
DOCNO- medline/29729541

377 - TOXLINE
TI - Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming
growth factor (TGF-&beta;) pathways in placental JEG-3 trophoblast cells
via reactive oxygen species.
AU - Adebambo OA
AD - Department of Biological Sciences, North Carolina State University, USA.
AU - Shea D
AD - Department of Biological Sciences, North Carolina State University, USA.
AU - Fry RC
AD - Department of Environmental Science and Engineering, Gillings School of
Global Public Health, University of North Carolina at Chapel Hill, USA. Electronic
address: rfry@unc.edu.
SO - Toxicol Appl Pharmacol. 2018, Feb 08; 342:108-115. [Toxicology and applied
pharmacology]
AB - Epidemiologic studies indicate an association between exposure to cadmium
(Cd) and placental-related pregnancy disorders. While a precise mechanism
is unknown, oxidative imbalance and dysregulation of the hypoxia inducible
factor (HIF) and transforming growth factor beta (TGF-&beta;) pathways
have been implicated in placental disease pathogenesis. Here we
investigated key oxidative and placentation pathways in JEG-3 placental
trophoblast cells treated with Cd alone, environmental water samples
predominated by Cd with low concentrations of other metals (e.g. inorganic
arsenic (iAs)) collected from a waste-site, and a matched mixture of Cd
and iAs prepared in the laboratory. The induction of cytosolic reactive
oxygen species (ROS), expression of metallothionein (MT) isoforms,
HIF1&alpha; and downstream targets, and expression of TGF&beta;
pathway-associated genes and proteins were assessed. Additionally, the
effect of pre-treatment with the antioxidant N-acetyl cysteine (NAC) on
ROS generation and effects on HIF, MT and TGF-&beta; signaling pathways
was examined. Cd and Cd-mixture treated cells displayed higher levels of
ROSs with accompanying disruption of HIF and TGF&beta; pathway signaling
versus controls, with the Cd-mixture eliciting a greater effect.
Conversely, pretreatment with NAC reduced Cd-induced ROS production and
disruption of HIF, MT and TGF&beta; pathway signaling. The results
indicate that treatment of placental trophoblast cells with Cd results in
increased production of ROSs that disrupt placentation pathways involved
in disease pathogenesis. Also, co-occurrence of Cd with other toxic
metals, particularly arsenic, may induce detrimental health effects that
are currently underestimated when analyzed as single metals.
KW - Cadmium
KW - Gene expression
KW - Growth factor
KW - Hypoxia
KW - Placentation
KW - Reactive oxygen species
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180211
CI - Copyright &copy; 2018. Published by Elsevier Inc.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20180208
STAT- Publisher
DOCNO- medline/29408318

378 - TOXLINE
TI - [The establishment of the immortalized mouse brain microvascular pericytes
model and its preliminary application in screening of cerebrovascular
toxicants].
AU - Zhao HP
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Gao YF
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Xia D
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Zhao ZQ
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Wu S
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Wang XH
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Liu HX
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Xiao C
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - Xing XM
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
AU - He Y
AD - Sun Yat-sen University School of Public Health, Guangzhou 510080, China.
SO - Zhonghua Yu Fang Yi Xue Za Zhi. 2018, May 06; 52(5):538-544. [Zhonghua yu
fang yi xue za zhi [Chinese journal of preventive medicine]]
AB - Objective: To establish the immortalized mouse brain microvascular
pericytes model and to apply to the cerebrovascular toxicants screening
study. Methods: Brain pericytes were isolated from 3 weeks of mice by
tissue digestion. Immortalized pericyte cell line was constructed by
infecting with LT retrovirus. Monoclone was selected to purify the
immortalized pericyte cell line. The pericyte characteristics and purity
were explored by immunocytochemistry. Cell proliferation was measured by
using the Pomega MTS cell Proliferation Colorimetric Assay Kit. Pericytes
were treated with 0, 160, 320, 640, 1 280, 2 560 &mu;mol/L lead acetate,
0, 5, 10, 20, 40, 80 &mu;mol/L cadmium chloride and 0, 5, 10, 20, 40, 80
&mu;mol/L sodium arsenite in 24 hours. Cell toxicity of each group was
determined by MTS assay, median lethal dose (LD(50)) was calculated in
linear regression. Results: Mouse brain pericytes were successfully
isolated by tissue separation and enzyme digestion method. After
immortalized by LT retroviruses, monoclone was selected and expanded to
establish pericyte cell line. The brain pericytes exhibited typical long
spindle morphology and positive staining for &alpha;-SMA and Vimentin. The
proliferation of brain pericytes cell lines was very slowly, and the
doubling time was about 48 hours. The proliferation of immortalized brain
pericytes cell lines was very quickly, and the doubling time was about 24
hours. After lead acetate, cadmium chloride and sodium arsenite treatment
for 24 hours respectively, gradual declines in cell viability were
observed. The LD(50) of lead acetate was 2 025.0 &mu;mol/L, the LD(50) of
cadmium chloride was 36.6 &mu;mol/L, and the LD(50) of sodium arsenite was
33.2 &mu;mol/L. Conclusion: The immortalized mouse brain microvascular
pericyte model is established successfully by infecting with LT
retrovirus, and can be applied to screen cerebrovascular toxicants. The
toxicity of these toxicants to immortalized mouse brain microvascular
pericyte is in sequence: sodium arsenite,cadmium chloride, lead acetate.
AB - &#30446;&#30340;&#65306;

&#24314;&#31435;&#23567;&#40736;&#33041;&#24494;&#34880;&#31649;&#21608;&#32454;&#3
2990;&#27704;&#29983;&#21270;&#27169;&#22411;&#24182;&#24212;&#29992;&#20110;&#3304
1;&#34880;&#31649;&#27602;&#29289;&#31579;&#26597;&#30740;&#31350;&#12290;
&#26041;&#27861;&#65306;

&#21462;3&#21608;&#40836;&#38596;&#24615;C57BL/6&#23567;&#40736;2&#21482;&#65292;&#
21462;&#23567;&#40736;&#22823;&#33041;&#30382;&#36136;&#65292;&#29992;&#32452;&#324
55;&#20998;&#31163;&#21644;&#37238;&#28040;&#21270;&#27861;&#22521;&#20859;&#21407;
&#20195;&#23567;&#40736;&#33041;&#24494;&#34880;&#31649;&#21608;&#32454;&#32990;&#6
5292;&#36870;&#36716;&#24405;&#30149;&#27602;&#36716;&#26579;LT&#36136;&#31890;&#26
500;&#24314;&#27704;&#29983;&#21270;&#32454;&#32990;&#26666;&#12290;&#37319;&#29992
;&#21333;&#20811;&#38534;&#27861;&#32431;&#21270;&#32454;&#32990;&#65292;&#37319;&#
29992;&#32454;&#32990;&#20813;&#30123;&#33639;&#20809;&#37492;&#23450;&#32454;&#329
90;&#32431;&#24230;&#65292;MTS&#27861;&#32472;&#21046;&#32454;&#32990;&#29983;&#382
71;&#26354;&#32447;&#65292;&#23558;&#27704;&#29983;&#21270;&#23567;&#40736;&#33041;
&#24494;&#34880;&#31649;&#21608;&#32454;&#32990;&#20998;&#21035;&#26292;&#38706;&#2
0110;0&#12289;160&#12289;320&#12289;640&#12289;1
280&#12289;2 560

&mu;mol/L&#30340;&#37259;&#37240;&#38085;&#21644;0&#12289;5&#12289;10&#12289;20&#12
289;40&#12289;80

&mu;mol/L&#30340;&#27695;&#21270;&#38217;&#21450;0&#12289;5&#12289;10&#12289;20&#12
289;40&#12289;80
&mu;mol/L&#30340;&#20122;&#30775;&#37240;&#38048;24

h&#21518;&#65292;&#29992;MTS&#27861;&#26816;&#27979;&#32454;&#32990;&#27963;&#21147
;&#65292;&#29992;&#32447;&#24615;&#22238;&#24402;&#27861;&#35745;&#31639;&#19981;&#
21516;&#27602;&#29289;&#21322;&#25968;&#33268;&#27515;&#37327;&#65288;LD(50)&#65289
;&#12290;
&#32467;&#26524;&#65306;

&#27704;&#29983;&#21270;&#33041;&#24494;&#34880;&#31649;&#21608;&#32454;&#32990;&#2
1576;&#38271;&#26797;&#24418;&#29983;&#38271;&#65292;&#34920;&#36798;&#21608;&#3245
4;&#32990;&#29305;&#24322;&#24615;&#26631;&#35760;&#29289;&alpha;-
&#24179;&#28369;&#32908;&#32908;&#21160;&#34507;&#30333;&#65288;&alpha;-
SMA&#65289;&#65292;&#19988;&#37117;&#34920;&#36798;&#21151;&#33021;&#24615;&#25910;
&#32553;&#34507;&#30333;&#20013;&#38388;&#19997;&#34507;&#30333;-
&#27874;&#24418;&#34507;&#30333;&#65288;Vimentin&#65289;&#65307;&#21407;&#20195;&#3
3041;&#24494;&#34880;&#31649;&#21608;&#32454;&#32990;&#22686;&#27542;&#32531;&#2493
0;&#65292;&#25509;&#31181;&#31532;3&#22825;&#36827;&#20837;&#23545;&#25968;&#29983;
&#38271;&#26399;&#65292;&#20493;&#22686;&#26102;&#38388;&#20026;48

h&#65307;&#27704;&#29983;&#21270;&#33041;&#24494;&#34880;&#31649;&#21608;&#32454;&#
32990;&#22686;&#27542;&#26106;&#30427;&#65292;&#25509;&#31181;&#31532;3&#22825;&#36
827;&#20837;&#23545;&#25968;&#29983;&#38271;&#26399;&#65292;&#20493;&#22686;&#26102
;&#38388;&#20026;24

h&#65307;&#27704;&#29983;&#21270;&#33041;&#24494;&#34880;&#31649;&#21608;&#32454;&#
32990;&#29983;&#23384;&#29575;&#38543;&#21508;&#27602;&#29289;&#26579;&#27602;&#210
58;&#37327;&#30340;&#22686;&#21152;&#21576;&#29616;&#19979;&#38477;&#36235;&#21183;
&#65292;&#37259;&#37240;&#38085;LD(50)&#20026;2
025.0 &mu;mol/L&#65292;&#27695;&#21270;&#38217;LD(50)&#20026;36.6
&mu;mol/L&#65292;&#20122;&#30775;&#37240;&#38048;LD(50)&#20026;33.2
&mu;mol/L&#12290; &#32467;&#35770;&#65306;

&#21033;&#29992;&#36870;&#36716;&#24405;&#30149;&#27602;&#36716;&#26579;LT&#36136;&
#31890;&#21487;&#25104;&#21151;&#26500;&#24314;&#27704;&#29983;&#21270;&#23567;&#40
736;&#33041;&#24494;&#34880;&#31649;&#21608;&#32454;&#32990;&#65292;&#24182;&#21487
;&#24212;&#29992;&#20110;&#33041;&#34880;&#31649;&#27602;&#29289;&#31579;&#26597;&#
30740;&#31350;&#65292;&#23545;&#27704;&#29983;&#21270;&#23567;&#40736;&#33041;&#244
94;&#34880;&#31649;&#21608;&#32454;&#32990;&#30340;&#27602;&#24615;&#22823;&#23567;
&#20381;&#27425;&#20026;&#20122;&#30775;&#37240;&#38048;&#12289;&#27695;&#21270;&#3
8217;&#12289;&#37259;&#37240;&#38085;&#12290;.
KW - Cadmium chloride
KW - Cell toxicity
KW - Lead acetate
KW - Pericytes
KW - Sodium arsenite
LA - chi
IS - 0253-9624 (Print)
PT - English Abstract
PT - Journal Article
TA - Zhonghua Yu Fang Yi Xue Za Zhi
YR - 2018
DATE- 20180510
CITO- NLM
CS - China
FJT - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
STAT- In-Process
DOCNO- medline/29747347

379 - TOXLINE
TI - Public health risk of trace metals in fresh chicken meat products on the
food markets of a major production region in southern China.
AU - Hu Y
AD - MOE Laboratory of Groundwater Circulation and Evolution, School of Water
Resources and Environment, China University of Geosciences (Beijing), Beijing
100083, China.
AU - Zhang W
AD - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of
Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
AU - Chen G
AD - Department of Civil &amp; Environmental Engineering, Florida A&amp;M
University-Florida State University, Tallahassee, FL 32310, United States.
AU - Cheng H
AD - MOE Key Laboratory for Earth Surface Processes, College of Urban and
Environmental Sciences, Peking University, Beijing 100871, China. Electronic
address: hefac@umich.edu.
AU - Tao S
AD - MOE Key Laboratory for Earth Surface Processes, College of Urban and
Environmental Sciences, Peking University, Beijing 100871, China.
SO - Environ Pollut. 2018, Mar; 234:667-676. [Environmental pollution (Barking,
Essex : 1987)]
AB - Because most chickens are reared in intensive farms, where a range of feed
additives are used routinely, concerns have been raised on the potential
public health risk of chicken product consumption. This study was
conducted to characterize the contents of trace metals in fresh chicken
tissues (354 samples) on the food markets in Guangdong province of
southern China, a major region of chicken production with heavy per capita
chicken consumption, and to assess the public health risk from chronic
dietary exposure to the trace metals through chicken consumption. With the
exception of Cr, Ni, and Pb, the contents of trace metals were generally
higher in the chicken giblets (livers, gizzards, hearts, and kidneys)
compared to muscles (breasts and drumsticks). Chicken tissues from the
urban markets generally contained higher levels of As, Cu, Mn, and Zn than
those from the rural markets, while the contents of Pb were typically
higher in the chicken muscles from the rural markets. Results of
statistical analyses indicate that Cu, Zn, and As in the chicken tissues
derived mainly from the feeds, which is consistent with the widespread use
of Cu, Zn, and phenylarsenic compounds as feed supplements/additives in
intensive poultry farming. No non-carcinogenic risk is found with the
consumption of fresh chicken meat products on the food markets, while
approximately 70% of the adult population in Guangzhou and 30% of those in
Lianzhou have bladder and lung cancer risk above the serious or priority
level (10-4), which arises from the inorganic arsenic contained in the
chicken tissues. These findings indicate that the occurrence of inorganic
arsenic at elevated levels in chicken tissues on the food markets in
Guangdong province poses a significant public health risk, thus the use of
phenylarsenic feed additives in China's poultry farming should be
significantly reduced and eventually phased out.
KW - Cancer risk
KW - Chicken tissue
KW - Chronic dietary exposure
KW - Inorganic arsenic
KW - Phenylarsenic feed additive
KW - Trace metal
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180210
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171221
STAT- In-Process
DOCNO- medline/29227952

380 - TOXLINE
TI - Effects of washing, soaking and domestic cooking on cadmium, arsenic and
lead bioaccessibilities in rice.
AU - Liu K
AD - College of Food Science and Technology, Henan University of Technology,
Zhengzhou, China.
AU - Zheng J
AD - College of Food Science and Technology, Henan University of Technology,
Zhengzhou, China.
AU - Chen F
AD - College of Food Science and Technology, Henan University of Technology,
Zhengzhou, China.
SO - J Sci Food Agric. 2018, Aug; 98(10):3829-3835. [Journal of the science of
food and agriculture]
AB - BACKGROUND: The health risk of heavy metals such as cadmium (Cd), arsenic
(As) and lead (Pb) in rice can be assessed by their concentration and
bioaccessibility. In this work, japonica cultivar Xinfeng 2 and indica
cultivar T-You 15 were washed, soaked and cooked using three common
domestic cooking methods. The present study investigated the effects of
washing, soaking, normal cooking, high-pressure cooking and microwave
cooking on the concentration, bioaccessibility and health risk of Cd, As
and Pb in rice.
AB - RESULTS: Washing significantly reduced concentrations of Cd, As and Pb,
and all three types of cooking reduced bioaccessibilities of these
elements. No significant differences in bioaccessibility were observed
among rice prepared with different cooking methods. Concentrations and
bioaccessibilities of Cd, As and Pb highly affected the values of average
daily dose, hazard quotient and lifetime cancer risk. High concentration
and bioaccessibility cause As to pose non-carcinogenic and carcinogenic
health risks to adults and children. Moreover, compared with adults,
children have a high chance of exposure to non-carcinogenic and
carcinogenic health risks.
AB - CONCLUSION: Washing and cooking of rice lowered the health risk by
reducing Cd, As and Pb concentrations and bioaccessibilities respectively.
&copy; 2018 Society of Chemical Industry.
KW - bioaccessibility
KW - health risk assessment
KW - heavy metals
KW - rice cooking
LA - eng
IS - 1097-0010 (Electronic)
PT - Journal Article
TA - J Sci Food Agric
YR - 2018
DATE- 20180612
CI - &copy; 2018 Society of Chemical Industry.
CITO- NLM
CS - England
FJT - Journal of the science of food and agriculture
EDAT- 20180312
STAT- In-Process
DOCNO- medline/29363749

381 - TOXLINE
TI - Using urine as a biomarker in human exposure risk associated with arsenic
and other heavy metals contaminating drinking groundwater in intensively
agricultural areas of Thailand.
AU - Wongsasuluk P
AD - Center of Excellence on Hazardous Substance Management (HSM), Chulalongkorn
University, Bangkok, 10330, Thailand.
AU - Chotpantarat S
AD - Research Unit on Site Remediation on Metals Management from Industry and
Mining (Site Rem), Chulalongkorn University, Bangkok, Thailand. csrilert@gmail.com.
AU - Siriwong W
AD - College of Public Health Science, Chulalongkorn University, Bangkok, 10330,
Thailand.
AU - Robson M
AD - School of Environmental and Biological Sciences, Rutgers University, New
Brunswick, NJ, USA.
SO - Environ Geochem Health. 2018, Feb; 40(1):323-348. [Environmental
geochemistry and health]
AB - Urine used as a biomarker was collected and compared between two groups of
participants: (1) a groundwater-drinking group and (2) a
non-groundwater-drinking group in intensively agricultural areas in Ubon
Ratchathani province, Thailand. The statistical relationship with the
metal concentration in shallow groundwater wells was established with
urine data. According to the groundwater data, the health risk assessment
results for four metals appeared to be higher for participants who drank
groundwater than for the other group. The carcinogenic risk and
non-carcinogenic risk of arsenic (As) were found in 25.86 and 31.03% of
participants, respectively. For lead (Pb), 13.79% of the participants had
a non-carcinogenic risk. Moreover, 30 of the 58 participants in the
groundwater-drinking group had As urine higher than the standard, and 26,
2 and 9 of the 58 participants had above-standard levels for cadmium (Cd),
Pb and mercury (Hg) in urine, respectively. Both the risk assessment and
biomarker level of groundwater-drinking participants were higher than in
the other group. The results showed an average drinking rate of
approximately 4.21 &plusmn; 2.73 L/day, which is twice as
high as the standard. Interestingly, the As levels in the groundwater
correlated with those in the urine of the groundwater-drinking
participants, but not in the non-groundwater-drinking participants, as
well as with the As-related cancer and non-carcinogenic risks. The hazard
index (HI) of the 100 participants ranged from 0.00 to 25.86, with an
average of 1.51 &plusmn; 3.63 higher than the acceptable level,
revealing that 28 people appeared to have non-carcinogenic risk levels (24
and 4 people for groundwater-drinking participants and
non-groundwater-drinking participants, respectively). Finally, the
associated factors of heavy metals in urine were the drinking water
source, body weight, smoking, sex and use of personal protective
equipment.
KW - Biomarker
KW - Groundwater
KW - Heavy metals
KW - Risk assessment
KW - Thailand
KW - Urine
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180209
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20170207
STAT- In-Process
CM - Cites: Environ Int. 2010 Aug;36(6):563-9 (medline /20471088)
CM - Cites: Best Pract Res Clin Endocrinol Metab. 2010 Feb;24(1):77-88 (medline
/20172472)
CM - Cites: J Expo Sci Environ Epidemiol. 2014 Mar-Apr;24(2):127-34 (medline
/24192660)
CM - Cites: Environ Res. 2009 Jul;109(5):575-81 (medline /19419713)
CM - Cites: Environ Res. 2008 Feb;106(2):212-8 (medline /17900556)
CM - Cites: Regul Toxicol Pharmacol. 2014 Jun;69(1):49-54 (medline /24582650)
CM - Cites: Int J Hyg Environ Health. 2010 Nov;213(6):414-27 (medline
/20956086)
CM -Cites: Environ Int. 2011 Jan;37(1):80-5 (medline /20678797)
CM -Cites: Talanta. 2013 Nov 15;116:764-9 (medline /24148471)
CM -Cites: Sci Rep. 2016 May 09;6:25656 (medline /27156998)
CM -Cites: Sci Total Environ. 2006 Apr 1;358(1-3):97-120 (medline /16055168)
CM -Cites: Eur J Clin Nutr. 2000 Apr;54(4):361-3 (medline /10745289)
CM -Cites: Environ Geochem Health. 2014 Feb;36(1):169-82 (medline /23771812)
CM -Cites: J Expo Sci Environ Epidemiol. 2015 May;25(3):308-16 (medline
/25073435)
CM - Cites: Sci Total Environ. 2011 Feb 15;409(6):1172-80 (medline /21211822)
CM - Cites: Environ Int. 2012 Feb;39(1):150-71 (medline /22208756)
CM - Cites: J Epidemiol Community Health. 2006 Feb;60(2):168-72 (medline
/16415269)
CM - Cites: Environ Res. 2013 Oct;126:134-44 (medline /23777639)
CM - Cites: Sci Total Environ. 2004 Jun 29;326(1-3):33-47 (medline /15142763)
CM - Cites: Environ Geochem Health. 2009 Apr;31 Suppl 1:9-21 (medline
/19137402)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008
Jul-Sep;26(3):300-16 (medline /18781539)
CM - Cites: Environ Monit Assess. 2015 Mar;187(3):63 (medline /25647791)
CM - Cites: Maedica (Buchar). 2011 Oct;6(4):247-57 (medline /22879836)
CM - Cites: Environ Geochem Health. 2014 Oct;36(5):845-54 (medline /24737417)
CM - Cites: Environ Int. 2009 Apr;35(3):455-60 (medline /18774174)
CM - Cites: Environ Res. 2007 Feb;103(2):191-7 (medline /16890218)
CM - Cites: Sci Total Environ. 2011 Sep 15;409(20):4222-8 (medline /21831408)
CM - Cites: Sci Total Environ. 2011 Sep 15;409(20):4484-8 (medline /21784505)
DOCNO- medline/28176197

382 - TOXLINE
TI - Nevada desert dust with heavy metals suppresses IgM antibody production.
AU - Keil DE
AD - Department of Microbiology and Immunology, Montana State University, PO Box
173520, Bozeman, MT, 59717, USA.
AU - Buck B
AD - Department of Geoscience, University of Nevada Las Vegas, 4505 S. Maryland
Pkwy., Las Vegas, NV, 89154, USA.
AU - Goossens D
AD - Department of Earth and Environmental Sciences, KU Leuven, Celestijnenlaan
200E, 3001 Leuven, Belgium.
AU - McLaurin B
AD - Department of Environmental, Geographical, and Geological Sciences,
Bloomsburg University of Pennsylvania, Bloomsburg, PA, 17815, USA.
AU - Murphy L
AD - Department of Microbiology and Immunology, Montana State University, PO Box
173520, Bozeman, MT, 59717, USA.
AU - Leetham-Spencer M
AD - Department of Microbiology and Immunology, Montana State University, PO Box
173520, Bozeman, MT, 59717, USA.
AU - Teng Y
AD - Department of Geoscience, University of Nevada Las Vegas, 4505 S. Maryland
Pkwy., Las Vegas, NV, 89154, USA.
AU - Pollard J
AD - Department of Geoscience, University of Nevada Las Vegas, 4505 S. Maryland
Pkwy., Las Vegas, NV, 89154, USA.
AU - Gerads R
AD - Brooks Applied Labs, 18804 North Creek Parkway, Bothell, WA, 98011, USA.
AU - DeWitt JC
AD - Department of Pharmacology and Toxicology, East Carolina University, 600 Moye
Blvd., Greenville, NC, 27834, USA.
SO - Toxicol Rep. 2018; 5:258-269. [Toxicology reports]
AB - Systemic health effects from exposure to a complex natural dust containing
heavy metals from the Nellis Dunes Recreation Area (NDRA) near Las Vegas,
NV, were evaluated. Several toxicological parameters were examined
following lung exposure to emissive dust from three geologic sediment
types heavily used for recreational off-road activities: yellow sand very
rich in arsenic (termed CBN 5); a shallow cover of loose dune sand
overlying a gravelly subsoil bordering dune fields (termed CBN 6); and
brown claystone and siltstone (termed CBN 7). Adult female B6C3F1 mice
were exposed by oropharyngeal administration to these three types of
geogenic dusts at 0.01-100&#8239;mg of dust/kg of body weight, once per
week for four weeks. The median grain sizes were 4.6, 3.1, and
4.4&#8239;&mu;m, for CBN 5, 6, and 7, respectively. Each type of dust
contained quantifiable amounts of aluminum, vanadium, chromium, manganese,
iron, cobalt, copper, zinc, arsenic, strontium, cesium, lead, uranium, and
others. Descriptive markers of immunotoxicity, neurotoxicity, hematology,
and clinical chemistry parameters were assessed. Notable among all three
CBN units was a systemic, dose-responsive decrease in antigen-specific IgM
antibody responses. Geogenic dust from CBN 5 produced more than a 70%
suppression in IgM responses, establishing a lowest adverse effect level
(LOAEL) of 0.01&#8239;mg/kg. A suppression in IgM responses and a
corresponding increase in serum creatinine determined a LOAEL of
0.01&#8239;mg/kg for CBN 6. The LOAEL for CBN 7 was 0.1&#8239;mg/kg and
also was identified from suppression in IgM responses. These results are
of concern given the frequent off-road vehicle traffic and high visitor
rates at the NDRA, estimated at 300,000 each year.
KW - Geogenic dust
KW - Heavy metals
KW - Immunotoxicity
KW - Neurotoxicity
KW - Particulate matter
LA - eng
IS - 2214-7500 (Electronic)
PT - Journal Article
TA - Toxicol Rep
YR - 2018
DATE- 20180603
CITO- NLM
CS - Ireland
FJT - Toxicology reports
EDAT- 20180209
STAT- PubMed-not-MEDLINE
CM - Cites: Interdiscip Toxicol. 2012 Jun;5(2):47-58 (medline /23118587)
CM - Cites: Environ Health Perspect. 2009 Jul;117(7):1108-15 (medline
/19654921)
CM - Cites: Neurotoxicology. 2008 Jan;29(1):109-15 (medline /18001836)
CM - Cites: Toxicol Appl Pharmacol. 2016 Aug 1;304:79-89 (medline /27221630)
CM - Cites: J Epidemiol Community Health. 2013 Feb;67(2):125-31 (medline
/22826296)
CM - Cites: Fundam Appl Toxicol. 1993 Jul;21(1):71-82 (medline /8365588)
CM - Cites: Toxicol Sci. 2007 Nov;100(1):75-87 (medline /17682005)
CM - Cites: Sci Total Environ. 2009 Dec 1;407(24):6196-204 (medline /19793609)
CM - Cites: Environ Res. 2008 Mar;106(3):393-400 (medline /17959168)
CM - Cites: Epidemiology. 2008 Nov;19(6):800-7 (medline /18938653)
CM - Cites: Air Qual Atmos Health. 2012 Mar;5(1):63-77 (medline /22408694)
CM - Cites: Toxicol Rep. 2016 Sep 23;3:785-795 (medline /28959605)
CM - Cites: J Appl Toxicol. 2016 Oct;36(10 ):1276-83 (medline /26922875)
CM - Cites: Am J Respir Crit Care Med. 2010 Dec 15;182(12):1475-81 (medline
/20656941)
CM - Cites: J Clin Immunol. 2009 Jul;29(4):461-9 (medline /19247822)
CM - Cites: Environ Health Perspect. 2016 Apr;124(4):413-9 (medline /26219103)
CM - Cites: Environ Health Perspect. 2016 Nov;124(11):1735-1743 (medline
/27128449)
CM - Cites: Environ Health Perspect. 1999 Oct;107 Suppl 5:767-75 (medline
/10502543)
CM - Cites: Toxicol Appl Pharmacol. 2009 Dec 15;241(3):253-9 (medline
/19800901)
CM - Cites: Toxicol Rep. 2016 Dec 08;4:19-31 (medline /28959621)
CM - Cites: Environ Health Perspect. 2008 Apr;116(4):524-31 (medline /18414638)
CM - Cites: Chem Res Toxicol. 2014 Apr 21;27(4):690-8 (medline /24611629)
CM - Cites: Environ Health Perspect. 1994 Dec;102(12):1052-6 (medline /7536156)
CM - Cites: Springerplus. 2015 Aug 21;4:438 (medline /26312203)
CM - Cites: PLoS One. 2014 Apr 08;9(4):e93920 (medline /24714590)
CM - Cites: J Environ Manage. 2009 Aug;90(11):3458-69 (medline /19540651)
CM - Cites: Toxicol Sci. 2009 Mar;108(1):110-23 (medline /19141786)
CM - Cites: Chemosphere. 2005 May;59(8):1197-206 (medline /15833495)
CM - Cites: Toxicol Appl Pharmacol. 2016 Jan 15;291:1-12 (medline /26644169)
CM - Cites: Toxicol Appl Pharmacol. 2010 Jun 15;245(3):344-51 (medline
/20353797)
DOCNO- medline/29854597

383 - TOXLINE
TI - Seabirds as regional biomonitors of legacy toxicants on an urbanized
coastline.
AU - Clatterbuck CA
AD - San Diego State University, Biology Department, San Diego, CA, USA;
University of California-Davis, Graduate Group in Ecology, Davis, CA, USA.
Electronic address: cclatterbuck@ucdavis.edu.
AU - Lewison RL
AD - San Diego State University, Biology Department, San Diego, CA, USA.
AU - Dodder NG
AD - San Diego State University Research Foundation, San Diego, CA, USA.
AU - Zeeman C
AD - US Fish and Wildlife Service, Carlsbad Fish &amp; Wildlife Office, Carlsbad,
CA, USA.
AU - Schiff K
AD - Southern California Coastal Water Research Project, Costa Mesa, CA, USA.
SO - Sci Total Environ. 2018, Apr 01; 619-620:460-469. [The Science of the
total environment]
AB - Seabirds are often cited as sentinels of the marine environment, but are
rarely used in traditional ocean and coastal contaminant monitoring. Four
classes of persistent organic pollutants (POPs, n=68) and three trace
elements (mercury, selenium, and arsenic) were measured in the eggs of
California least terns (Sterna antillarum browni), caspian terns
(Hydroprogne caspia), double-crested cormorants (Phalacrocorax auritus),
and western gulls (Larus occidentalis) that nest in the Southern
California Bight. Building on a periodic five year regional monitoring
program, we measured contaminant exposure and assessed the utility of
seabirds as regional contaminant biomonitors. We found that the eggs of
larger, more piscivorous species generally had the highest concentrations
of POPs and trace elements while California least terns had the lowest
concentrations, except for mercury which was higher in least terns. As
expected, DDT concentrations were elevated near the Palos Verdes Superfund
site. However, we also detected a previously unknown latitudinal pattern
in PBDE concentrations in least terns. POP congener profiles also
confirmed differences in contamination in urban least tern colonies
closest to urban centers. Though toxicants were at detectable levels
across species and sites, concentrations were below those known to cause
adverse effects in avian taxa and are steady or declining compared to
previous studies in this region. Our results suggest that regional seabird
monitoring can inform site-specific remediation and support management and
protection of regionally-threatened wildlife and coastal systems.
Integration of seabird contaminant data with traditional sediment, water,
bivalve and fish monitoring is needed to further our understanding of
exposure pathways and food web contaminant transfer.
KW - Arsenic
KW - Biomonitoring
KW - Chlordanes
KW - DDTs
KW - Mercury
KW - PBDEs
KW - PCBs
KW - POPs
KW - Seabirds
KW - Selenium
KW - Trace elements
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180209
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20171129
STAT- In-Process
DOCNO- medline/29156266

384 - TOXLINE
TI - High-sensitivity quantitative analysis reveals the non-linear relationship
between the dose and deposition of diphenylarsinic acid in the rat central
nervous system following its subchronic exposure.
AU - Masuda T
AD - Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki
305-8575, Japan; Doctoral and Master's Programs in Kansei, Behavioral and Brain
Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba,
Ibaraki 305-8577, Japan. Electronic address: tmasu@md.tsukuba.ac.jp.
AU - Ishii K
AD - Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki
305-8575, Japan. Electronic address: kazishii@md.tsukuba.ac.jp.
AU - Nakayama T
AD - Department of Pediatrics, Ibaraki Prefectural University of Health Sciences,
Ibaraki 300-0331, Japan.
AU - Iwasaki N
AD - Department of Pediatrics, Ibaraki Prefectural University of Health Sciences,
Ibaraki 300-0331, Japan.
AU - Shibata Y
AD - Center for Environmental Measurement and Analysis, National Institute for
Environmental Studies, Ibaraki 305-8506, Japan.
AU - Tamaoka A
AD - Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki
305-8575, Japan.
SO - Neurotoxicol Teratol. 2018 Jan - Feb; 65:26-33. [Neurotoxicology and
teratology]
AB - In the year 2003, the residents of Kamisu, Japan, were exposed to
pentavalent organic arsenic diphenylarsinic acid (DPAA[V]) via their
normal drinking water. Following the exposure, they developed cerebellar
and brainstem symptoms. Although the relatively high dose of DPAA(V) is
assumed to have caused their symptoms, the relationship between the
exposed dose of DPAA(V) and the level of their deposition in the central
nervous system (CNS) remains unclear. Using liquid chromatography-tandem
mass spectrometry, we examined the deposition of DPAA(V) and its
pentavalent metabolites in the CNS tissues of Crl:CD(SD) rats following
the administration of DPAA(V) for 28days. We found that the concentrations
of DPAA(V) in the CNS were very high, given a dose of 5.0mg/kg/day.
However, very low concentrations of DPAA(V) were detected at a dose of 0.3
or 1.2mg/kg/day, suggesting the absence of a linear dose-response
relationship between the dose and deposition of DPAA(V). We also found
that this non-linear relationship was commonly observed in various non-CNS
tissues, including the excretory system. Our study showed for the first
time the exact relationship between the dose and tissue deposition of the
organic arsenic following its subchronic administration.
KW - Arsenic compound
KW - Cerebrum
KW - LC–MS/MS
KW - Rodent
LA - eng
IS - 1872-9738 (Electronic)
PT - Journal Article
TA - Neurotoxicol Teratol
YR - 2018
DATE- 20180207
CI - Copyright &copy; 2017 The Authors. Published by Elsevier Inc. All rights
reserved.
CITO- NLM
CS - United States
FJT - Neurotoxicology and teratology
EDAT- 20171207
STAT- In-Data-Review
DOCNO- medline/29225007

385 - TOXLINE
TI - Status and interrelationship of toenail elements in Pacific children.
AU - Karatela S
AD - University of Queensland, Faculty of Medicine School of Public Health,
Herston Road, Herston, QLD 4006, Australia. Electronic address:
s.karatela@uq.edu.au.
AU - Ward NI
AD - University of Surrey, Department of Chemistry FEPS, Guildford, Surrey GU2
7XH, UK.
AU - Zeng IS
AD - Middlemore Hospital, 100 Hospital Road, Otahuhu, 1640, Auckland, New Zealand.
AU - Paterson J
AD - AUT University, School of Public Health and Psychosocial Studies, Auckland,
New Zealand.
SO - J Trace Elem Med Biol. 2018, Mar; 46:10-16. [Journal of trace elements in
medicine and biology : organ of the Society for Minerals and Trace
Elements (GMS)]
AB - OBJECTIVE: Elemental deficiencies or in excess effects growth and
development. Pacific population are at a disadvantage due to food
insecurity as compared to New Zealand European households. This study aims
to evaluate the status and interrelationship of elements (essential,
non-essential and toxic) in nine-year-old Pacific children who were part
of the Pacific Island Families Study living in New Zealand.
AB - MATERIALS AND METHODS: This observational study included 278 eligible
nine-year-old children. Essential elements (including calcium, chromium,
cobalt, copper, iodine, iron, magnesium, manganese, selenium, zinc,
molybdenum), non-essential and toxic elements (arsenic, aluminum,
antimony, boron, cadmium, lead, mercury, nickel,) were determined in
toenails and after acid digestion, analysed using inductively coupled
plasma mass spectrometry. Principal component analysis and multivariate
analysis of covariance was used to identify differences in the groups of
elements and the inter-correlations between elements.
AB - RESULTS: The mean calcium (868&mu;g/g Ca), selenium (0.35&mu;g/g Se) and
zinc (129&mu;g/g Zn) concentrations were lower while the mean cadmium
(0.21&mu;g/g Cd) lead (0.86&mu;g/g Pb) and mercury (0.72&mu;g/g Hg)
concentrations were higher than the optimal health requirements. Ethnic
differences in relation to toenail elemental concentrations were observed
for aluminium and iron. Gender differences were observed for aluminium,
antimony, arsenic and lead. Selenium and molybdenum were inversely
associated with mercury. Manganese, zinc and calcium were positively
associated.
AB - CONCLUSIONS: This research contributes to the understanding of the
elemental concentrations for Pacific children by using tissue samples from
toenails, which improves the completeness of sampling than other tissues
and provides a longer exposure time frame. The study also reports several
inter-correlations between essential, non-essential and toxic elements in
Pacific Island population.
KW - Trace elements
KW - child nutrition
KW - nail biomarker
LA - eng
IS - 1878-3252 (Electronic)
PT - Journal Article
TA - J Trace Elem Med Biol
YR - 2018
DATE- 20180207
CI - Copyright &copy; 2017 Elsevier GmbH. All rights reserved.
CITO- NLM
CS - Germany
FJT - Journal of trace elements in medicine and biology : organ of the Society
for Minerals and Trace Elements (GMS)
EDAT- 20171110
STAT- In-Process
DOCNO- medline/29413098

386 - TOXLINE
TI - Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two
Interrelated Public Health Problems on the Rise.
AU - Bonini MG
AD - Department of Pathology, University of Illinois at Chicago, Chicago, IL, USA.
AU - Sargis RM
AD - Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
SO - Curr Opin Toxicol. 2018, Feb; 7:52-59. [Current opinion in toxicology]
AB - Rates of type 2 diabetes mellitus (T2DM) are rising rapidly across the
globe and the impact of this devastating disease threatens to plague the
21st century. While some contributing factors are well-recognized (e.g.
sedentary lifestyles and caloric excess), others diabetes-promoting risk
factors are less established or poorly appreciated. The latter category
includes environmental exposures to diabetogenic contaminants. Herein we
review some of the latest concepts and mechanisms by which environmental
exposures may contribute to rising rates of T2DM with a particular focus
on mechanisms involving mitochondrial dysfunction and imbalances in
reactive oxygen species (ROS). Furthermore, while the pathogenesis of
diabetes includes impairments in insulin sensitivity as well as insulin
secretion, we will specifically delve into the links between environmental
exposures to toxicants such as arsenic and disruptions in insulin release
from pancreatic &beta;-cells. Since &beta;-cell death or dysfunction lies
at the heart of both T2DM as well as type 1 diabetes mellitus (T1DM),
environmental endocrine disrupting chemicals (EDCs) that disrupt the
production or regulated release of the glucose-lowering hormone insulin
are likely contributors to diabetes risk. Importantly, understanding the
contribution of toxicants to diabetes risk as well as improved
understanding of their mechanisms of action offer unique opportunities to
modulate diabetes risk via targeted therapeutics or public policy
interventions to reduce and remediate exposures.
KW - Arsenic
KW - Endocrine Disrupting Chemicals
KW - Oxidative Stress
KW - Selenium
KW - Type 2 Diabetes
LA - eng
IS - 2468-2934 (Print)
PT - Journal Article
TA - Curr Opin Toxicol
YR - 2018
DATE- 20180206
CITO- NLM
CS - Netherlands
FJT - Current opinion in toxicology
EDAT- 20171012
STAT- PubMed-not-MEDLINE
CM - Cites: Free Radic Biol Med. 1999 Oct;27(7-8):830-7 (medline /10515587)
CM - Cites: Free Radic Biol Med. 2011 Oct 1;51(7):1454-60 (medline /21816219)
CM - Cites: Food Chem Toxicol. 2014 Aug;70:144-50 (medline /24859355)
CM - Cites: Sci Rep. 2014 Nov 04;4:6894 (medline /25367288)
CM - Cites: J Endocrinol. 2012 Nov;215(2):303-11 (medline /22946080)
CM - Cites: Antioxid Redox Signal. 2014 Mar 20;20(9):1423-35 (medline
/23919724)
CM - Cites: Diabetes. 2010 Apr;59(4):861-71 (medline /20103705)
CM - Cites: Toxicol Appl Pharmacol. 2009 Aug 15;239(1):29-36 (medline
/19446573)
CM - Cites: Int J Mol Sci. 2012 Sep 26;13(10 ):12349-66 (medline /23202902)
CM - Cites: Antioxid Redox Signal. 2014 May 10;20(14):2114-29 (medline
/24252128)
CM - Cites: Diabetologia. 2006 Jun;49(6):1254-63 (medline /16570159)
CM - Cites: PLoS One. 2013;8(2):e54374 (medline /23405080)
CM - Cites: PLoS One. 2015 Dec 01;10 (12 ):e0142818 (medline /26624291)
CM - Cites: PLoS One. 2010 Dec 28;5(12):e15912 (medline /21206533)
CM - Cites: Toxicology. 1997 Sep 5;121(3):229-37 (medline /9231701)
CM - Cites: Diabetologia. 2008 Aug;51(8):1515-24 (medline /18560803)
CM - Cites: Toxicology. 2012 Sep 28;299(2-3):165-71 (medline /22664483)
CM - Cites: Metabolism. 2004 Apr;53(4):488-94 (medline /15045697)
CM - Cites: Diabetes. 2009 Mar;58(3):673-81 (medline /19073765)
CM - Cites: Diabetes Care. 2013 Apr;36(4):1033-46 (medline /23468086)
CM - Cites: Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8852-7 (medline
/15184668)
CM - Cites: Toxicology. 2017 Nov 1;391:84-89 (medline /28750850)
CM - Cites: Arch Physiol Biochem. 2014 Feb;120(1):22-8 (medline /24040897)
CM - Cites: Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E134-44 (medline
/20959538)
CM - Cites: Environ Health. 2011 Aug 24;10:73 (medline /21864395)
CM - Cites: Environ Health Perspect. 2012 Dec;120(12 ):1658-70 (medline
/22889723)
CM - Cites: Eur J Clin Invest. 2013 Jun;43(6):579-88 (medline /23590571)
CM - Cites: Environ Health. 2013 Jul 01;12:52 (medline /23816141)
CM - Cites: Curr Environ Health Rep. 2017 Jun;4(2):208-222 (medline /28432637)
CM - Cites: Arch Toxicol. 2017 Sep;91(9):3135-3144 (medline /28180948)
CM - Cites: Biochim Biophys Acta. 2017 Aug;1858(8):628-632 (medline /28087256)
CM - Cites: J Cell Mol Med. 2015 Mar;19(3):581-94 (medline /25418486)
CM - Cites: Diabetes. 2006 Jun;55(6):1614-24 (medline /16731823)
CM - Cites: Pulm Circ. 2013 Dec;3(4):816-30 (medline /25006397)
CM - Cites: Trials. 2016 Apr 27;17 (1):218 (medline /27121115)
CM - Cites: Toxicol Rep. 2014 Aug 02;1:513-521 (medline /28962265)
CM - Cites: Diabetes Care. 2016 Jan;39 Suppl 1:S60-71 (medline /26696684)
CM - Cites: Ann Intern Med. 2007 Aug 21;147(4):217-23 (medline /17620655)
CM - Cites: Environ Res. 2007 Jul;104(3):383-9 (medline /17475235)
CM - Cites: Biomed Res Int. 2015;2015:368087 (medline /26000288)
CM - Cites: Circ Res. 2010 Oct 29;107(9):1058-70 (medline /21030723)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):207-13 (medline
/17301251)
CM - Cites: Arch Biochem Biophys. 1993 Feb 1;300(2):535-43 (medline /8434935)
CM - Cites: Sci Rep. 2016 Jun 13;6:27882 (medline /27292372)
CM - Cites: Environ Res. 2015 Oct;142:257-63 (medline /26186133)
CM - Cites: Cancer Cell. 2011 Mar 8;19(3):416-28 (medline /21397863)
CM - Cites: Nutr J. 2016 May 04;15(1):48 (medline /27142520)
CM - Cites: Cell Death Dis. 2013 Jan 17;4:e460 (medline /23328667)
CM - Cites: Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1791-806 (medline
/16987032)
CM - Cites: Environ Health Perspect. 2011 Nov;119(11):1665-70 (medline
/21742576)
CM - Cites: Biochim Biophys Acta. 2010 Feb;1802(2):240-6 (medline /19883754)
CM - Cites: Adv Exp Med Biol. 2012;771:272-87 (medline /23393685)
CM - Cites: Diabetes. 2007 Jul;56(7):1783-91 (medline /17400930)
CM - Cites: Free Radic Biol Med. 2011 May 15;50(10):1213-4 (medline /21338673)
CM - Cites: Science. 1938 Jul 22;88(2273):81 (medline /17841356)
CM - Cites: JAMA. 2011 Oct 12;306(14):1549-56 (medline /21990298)
CM - Cites: Ann Nutr Metab. 2012;60(2):157-68 (medline /22517293)
CM - Cites: Environ Health Perspect. 2009 Jul;117(7):1059-64 (medline
/19654913)
CM - Cites: Free Radic Biol Med. 2002 May 1;32(9):841-59 (medline /11978486)
CM - Cites: Chem Biol Interact. 2017 Mar 1;265:8-15 (medline /28115068)
CM - Cites: Environ Toxicol Pharmacol. 2015 Jan;39(1):16-26 (medline /25434758)
CM - Cites: Diabetes Care. 2016 Jan;39 Suppl 1:S72-80 (medline /26696685)
CM - Cites: Biochemistry (Mosc). 2016 Oct;81(10 ):1089-1100 (medline /27908234)
CM - Cites: Toxicol Sci. 2015 Aug;146(2):290-300 (medline /25979314)
CM - Cites: Reprod Toxicol. 2017 Mar;68:3-33 (medline /27760374)
CM - Cites: Diabetes Metab J. 2014 Feb;38(1):13-24 (medline /24627823)
CM - Cites: Mutat Res Genet Toxicol Environ Mutagen. 2014 Jul 15;769:29-33
(medline /25344109)
CM - Cites: Physiol Res. 2012;61(1):81-8 (medline /22188104)
CM - Cites: IUBMB Life. 2014 Mar 26;:null (medline /24668617)
CM - Cites: Circ Arrhythm Electrophysiol. 2014 Aug;7(4):701-10 (medline
/25017399)
CM - Cites: JAMA. 2009 Jan 7;301(1):39-51 (medline /19066370)
CM - Cites: Chem Res Toxicol. 2006 Aug;19(8):1080-5 (medline /16918248)
CM - Cites: Environ Health Perspect. 2000 Sep;108(9):847-51 (medline /11017889)
CM - Cites: J Nutr Biochem. 2016 Jun;32:128-41 (medline /27142746)
CM - Cites: Endocrinology. 1999 Aug;140(8):3422-8 (medline /10433196)
CM - Cites: J Exp Med. 2015 Sep 21;212(10 ):1725-38 (medline /26324446)
CM - Cites: Free Radic Biol Med. 1996;20(3):463-6 (medline /8720919)
DOCNO- medline/29392186

387 - TOXLINE
TI - Toxic elements as biomarkers for breast cancer: a meta-analysis study.
AU - Jouybari L
AD - Nursing Research Center, Goletsan University of Medical Sciences, Gorgan,
Iran.
AU - Saei Ghare Naz M
AD - Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti
University of Medical Sciences, Tehran, Iran.
AU - Sanagoo A
AD - Nursing Research Center, Goletsan University of Medical Sciences, Gorgan,
Iran.
AU - Kiani F
AD - Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
AU - Sayehmiri F
AD - Proteomics Research Center, Shahid Beheshti University of Medical Sciences,
Tehran, Iran.
AU - Sayehmiri K
AD - Department of Social Medicine, School of Medicine, Ilam University of Medical
Sciences, Ilam, Iran.
AU - Hasanpour Dehkordi A
AD - Department of Medical Surgical, Nursing and Midwifery, Shahrekord University
of Medical Sciences, Shahrekord, Iran.
SO - Cancer Manag Res. 2018; 10:69-79. [Cancer management and research]
AB - Aims and background: Breast cancer (BC) is responsible for a large
proportion of incidence of cancer in the world. Identifying the risk
factors contributing to the incidence of BC is crucial to find efficient
preventive and management strategies for this disease. Several studies
have examined Arsenic (As), Cadmium (Cd), and Nickel (Ni) as risk factors
for BC. The present study aimed at studying the link between As, Cd, and
Ni concentrations and BC by using a meta-analysis.
AB - Materials and methods: All case-control studies addressing the
relationship between As, Cd, and Ni concentrations with BC were identified
through electronic search databases (Scopus, ISI Web of Science, PubMed,
EmBase, and Cochrane Library). The relevant data obtained from these
papers were analyzed by a random-effects model. The heterogeneity of
studies was secured by using I2 index. Funnel plots and Egger's test were
used to examine publication bias.
AB - Results: In the present study, due to different measurement methods used
for measuring As, Cd, and Ni, the concentration of these elements was
measured in various subgroups (1: plasma, 2: breast tissue, and 3: scalp
hair and nail) of individuals with BC and healthy subjects. The overall
integration of data from the 3 groups led to the conclusion that there was
a significant difference in Cd and Ni statuses between healthy and BC
patients; the standard mean difference was 2.65 (95% CI: 1.57-3.73;
P=0.000) and 2.06 (95% CI: 1.20-3.32; P=0.000), respectively. Whereas,
there was no significant statistical difference in As status between
healthy subjects and BC patients; the standard mean difference between
them being 0.52 (95% CI: -0.12-1.16; P=0.114).
AB - Conclusion: The present study indicates that there is a direct and
positive association between Cd and Ni concentrations and BC risk. It is a
warning to health care providers and policy makers to find viable
solutions and take requisite measures to reduce BC risk in the society.
COI - Disclosure The authors report no conflicts of interest in this work.
KW - arsenic
KW - breast cancer
KW - cadmium
KW - malignancy
KW - meta-analysis
KW - nickel
KW - toxic element
LA - eng
IS - 1179-1322 (Print)
PT - Journal Article
PT - Review
TA - Cancer Manag Res
YR - 2018
DATE- 20180204
CITO- NLM
CS - New Zealand
FJT - Cancer management and research
EDAT- 20180110
STAT- PubMed-not-MEDLINE
CM - Cites: Biol Trace Elem Res. 2011 Dec;144(1-3):360-79 (medline /21660533)
CM - Cites: IARC Monogr Eval Carcinog Risks Hum. 1993;58:119-237 (medline
/8022055)
CM - Cites: Endocrinology. 2003 Jun;144(6):2425-36 (medline /12746304)
CM - Cites: J BUON. 2010 Jul-Sep;15(3):455-61 (medline /20941810)
CM - Cites: IARC Monogr Eval Carcinog Risk Chem Hum. 1980;23:39-141 (medline
/7000668)
CM - Cites: Toxicol Appl Pharmacol. 2009 Dec 15;241(3):269-74 (medline
/19766132)
CM - Cites: Oncotarget. 2015 Jun 10;6(16):14165-78 (medline /25909173)
CM - Cites: J Environ Pathol Toxicol Oncol. 2014;33(3):183-94 (medline
/25272057)
CM - Cites: Clin Cancer Res. 2010 Jul 15;16(14):3607-17 (medline /20519360)
CM - Cites: Environ Health Perspect. 2003 Feb;111(2):187-93 (medline /12573904)
CM - Cites: Mol Endocrinol. 2000 Apr;14(4):545-53 (medline /10770491)
CM - Cites: Cancer Biol Med. 2014 Jun;11(2):101-15 (medline /25009752)
CM - Cites: Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 (medline /12583988)
CM - Cites: Int J Environ Health Res. 2003 Sep;13(3):271-84 (medline /12909558)
CM - Cites: J Zhejiang Univ Sci B. 2007 Jan;8(1):1-13 (medline /17173356)
CM - Cites: Asian Pac J Cancer Prev. 2013;14(5):3105-8 (medline /23803087)
CM - Cites: Cas Lek Cesk. 1997 Nov 19;136(22):698-701 (medline /9476382)
CM - Cites: J Immunol. 2000 Oct 15;165(8):4290-7 (medline /11035063)
CM - Cites: Future Oncol. 2012 Jun;8(6):697-702 (medline /22764767)
CM - Cites: Am J Public Health. 2004 May;94(5):741-4 (medline /15117692)
CM - Cites: Cancer Res. 1994 Aug 1;54(15):4045-51 (medline /8033135)
CM - Cites: Oncotarget. 2015 Apr 20;6(11):9502-16 (medline /25909161)
CM - Cites: J Appl Toxicol. 2006 May-Jun;26(3):191-7 (medline /16489580)
CM - Cites: Med Oncol. 2011 Dec;28(4):1225-54 (medline /20458559)
CM - Cites: Cancer Res. 1984 Nov;44(11):5390-4 (medline /6488192)
CM - Cites: Reprod Biol Endocrinol. 2010 Jul 02;8:80 (medline /20598115)
CM - Cites: Pol J Pathol. 2011 Dec;62(4):257-61 (medline /22246912)
CM - Cites: Neuro Endocrinol Lett. 2006 Dec;27 Suppl 1:36-9 (medline /16804515)
CM - Cites: BMJ. 2009 Jul 21;339:b2700 (medline /19622552)
CM - Cites: Occup Environ Med. 1996 Oct;53(10):708-13 (medline /8943837)
CM - Cites: Asian Pac J Cancer Prev. 2016;17 (S3):43-6 (medline /27165206)
CM - Cites: Sci Total Environ. 1996 Jul 30;186(3):251-6 (medline /8677430)
CM - Cites: Mutat Res. 2009 Mar 31;674(1-2):109-15 (medline /18996220)
CM - Cites: Clin Lab Med. 1998 Dec;18(4):673-85 (medline /9891606)
CM - Cites: Sci Total Environ. 2007 Sep 20;383(1-3):52-8 (medline /17570463)
CM - Cites: Toxicol Sci. 2007 Jul;98(1):75-86 (medline /17283378)
CM - Cites: Toxicol Appl Pharmacol. 2013 Dec 1;273(2):281-8 (medline /23811327)
CM - Cites: Toxicol Sci. 2000 May;55(1):17-23 (medline /10788555)
CM - Cites: Aging (Albany NY). 2010 Nov;2(11):804-14 (medline /21071816)
CM - Cites: Biol Trace Elem Res. 1994 Dec;46(3):185-202 (medline /7702976)
CM - Cites: BMC Womens Health. 2010 Oct 20;10:28 (medline /20961453)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev.
2012;30(3):189-224 (medline /22970719)
CM - Cites: CA Cancer J Clin. 2015 Mar;65(2):87-108 (medline /25651787)
CM - Cites: IARC Monogr Eval Carcinog Risk Chem Man. 1976;11:75-112 (medline
/791825)
CM - Cites: Clin Med Insights Oncol. 2014 Jan 09;8:1-13 (medline /24453505)
CM - Cites: Curr Oncol. 2015 Apr;22(2):e51-60 (medline /25908921)
CM - Cites: Biol Trace Elem Res. 2010 May;134(2):160-73 (medline /19644659)
CM - Cites: J Natl Cancer Inst. 2006 Jun 21;98(12):869-73 (medline /16788160)
CM - Cites: J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):63-73 (medline
/23338949)
CM - Cites: J Cell Biochem. 2010 Dec 15;111(6):1546-55 (medline /20862710)
CM - Cites: Biol Trace Elem Res. 2010 Aug;136(2):127-39 (medline /20195925)
CM - Cites: J Biol Chem. 1979 Mar 25;254(6):1781-4 (medline /217870)
CM - Cites: Hum Exp Toxicol. 2011 Dec;30(12):2013-22 (medline /21558145)
CM - Cites: Cancer Res. 2012 Mar 15;72(6):1459-66 (medline /22422990)
CM - Cites: Lipids. 1982 May;17(5):331-7 (medline /7098774)
CM - Cites: Occup Environ Med. 2012 Feb;69(2):87-92 (medline /22039095)
CM - Cites: Anal Chim Acta. 2008 Aug 1;622(1-2):77-84 (medline /18602537)
CM - Cites: Oncotarget. 2015 Jun 20;6(17):15283-96 (medline /25909172)
CM - Cites: CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 (medline /21296855)
CM - Cites: Environ Health Perspect. 2012 Sep;120(9):1265-71 (medline
/22626610)
CM - Cites: Mol Cell Biol. 1995 May;15(5):2547-57 (medline /7537850)
CM - Cites: Clin Chim Acta. 2015 Jan 15;439:178-84 (medline /25446879)
CM - Cites: Biomed Sci Instrum. 2010;46:404-9 (medline /20467115)
CM - Cites: Ren Fail. 2004 Nov;26(6):607-11 (medline /15600250)
CM - Cites: Mol Pharmacol. 2001 Aug;60(2):302-9 (medline /11455017)
CM - Cites: J Toxicol. 2011;2011:159619 (medline /21804822)
CM - Cites: Am J Epidemiol. 1996 Oct 1;144(7):653-60 (medline /8823061)
CM - Cites: Qual Health Res. 2011 Jun;21(6):783-95 (medline /21411761)
CM - Cites: Cell Signal. 2002 Apr;14(4):327-40 (medline /11858940)
CM - Cites: Cancer Res. 1989 Aug 1;49(15):4210-5 (medline /2743308)
DOCNO- medline/29391828

388 - TOXLINE
TI - Distribution and transfer of potentially toxic metal(loid)s in Juncus
effusus from the indigenous zinc smelting area, northwest region of
Guizhou Province, China.
AU - Peng Y
AD - College of Resources and Environmental Engineering, Guizhou University,
Guiyang 550025, China.
AU - Chen J
AD - College of Resources and Environmental Engineering, Guizhou University,
Guiyang 550025, China.
AU - Wei H
AD - College of Resources and Environmental Engineering, Guizhou University,
Guiyang 550025, China.
AU - Li S
AD - Institute of Land Resources Survey and Plan of Guizhou Province, Guiyang
550004, China.
AU - Jin T
AD - Institute of Mountain Resources of Guizhou Province, Guizhou Academy of
Sciences, Guiyang 550001, China.
AU - Yang R
AD - College of Resources and Environmental Engineering, Guizhou University,
Guiyang 550025, China. Electronic address: rdyang@gzu.edu.cn.
SO - Ecotoxicol Environ Saf. 2018, May 15; 152:24-32. [Ecotoxicology and
environmental safety]
AB - We collected samples (i.e., the aerial parts and roots of Juncus effusus
and their growth media) in the indigenous zinc smelting area in the
northwest region of Guizhou Province, China, and we measured and analyzed
potentially toxic metal(loid)s (arsenic, As; cadmium, Cd; chromium, Cr;
copper, Cu; mercury, Hg; lead, Pb and zinc, Zn) in these samples. The
results include the following: First, there is a high concentration of one
or more potentially toxic metal(loid)s in the slag and surrounding soil in
the research area. This situation might be caused by metal(loid) damage or
contamination due to the circumstances. Additionally, Juncus effusus in
the indigenous zinc smelting area are contaminated by some potentially
toxic metal(loid)s; since they are used for Chinese medical materials, it
is especially significant that their As, Cd and Pb concentrations are
greater than their limited standard values. Finally, both the
bioconcentration factors and transfer factors for most potentially toxic
metal(loid)s in Juncus effusus are less than 1 in the study area.
Therefore, we suggest that Juncus effusus could be used for
phytostabilization or as a pioneer plant for phytoremediation of
potentially toxic metal(loid)s because it has a tolerance and exclusion
mechanism for these metal(loid)s in the research district.
KW - Bioconcentration factor
KW - Indigenous zinc smelting
KW - Juncus effusus
KW - Potentially toxic metal(loid)s
KW - Transfer factor
RN - J41CSQ7QDS
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180601
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180204
STAT- MEDLINE
DOCNO- medline/29367113

389 - TOXLINE
TI - Metals in mangrove ecosystems and associated biota: A global perspective.
AU - Kulkarni R
AD - Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune
University, Pune 411007, India.
AU - Deobagkar D
AD - Indian Space Research Organization Cell, Savitribai Phule Pune University,
Pune 411007, India.
AU - Zinjarde S
AD - Institute of Bioinformatics and Biotechnology, Savitribai Phule Pune
University, Pune 411007, India; Department of Microbiology, Savitribai Phule Pune
University, Pune 411007, India. Electronic address: smita@unipune.ac.in.
SO - Ecotoxicol Environ Saf. 2018, May 30; 153:215-228. [Ecotoxicology and
environmental safety]
AB - Mangrove forests prevalent along the intertidal regions of tropical and
sub-tropical coastlines are inimitable and dynamic ecosystems. They
protect and stabilize coastal areas from deleterious consequences of
natural disasters such as hurricanes and tsunamis. Although there are
reviews on ecological aspects, industrial uses of mangrove-associated
microorganisms and occurrence of pollutants in a region-specific manner,
there is no exclusive review detailing the incidence of metals in mangrove
sediments and associated biota in these ecosystems on a global level. In
this review, mangrove forests have been classified in a continent-wise
manner. Most of the investigations detail the distribution of metals such
as zinc, chromium, arsenic, copper, cobalt, manganese, nickel, lead and
mercury although in some cases levels of vanadium, strontium, zirconium
and uranium have also been studied. Seasonal, tidal, marine, riverine, and
terrestrial components are seen to influence occurrence, speciation,
bioavailability and fate of metals in these ecosystems. In most of the
cases, associated plants and animals also accumulate metals to different
extents and are of ecotoxicological relevance. Levels of metals vary in a
region specific manner and there is disparity in the pollution status of
different mangrove areas. Protecting these vulnerable ecosystems from
metal pollutants is important from environmental safety point of view.
KW - Bioavailability
KW - Biota
KW - Mangrove forests
KW - Metal pollution
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
PT - Review
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180601
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180213
STAT- MEDLINE
DOCNO- medline/29448175

390 - TOXLINE
TI - Moss bag monitoring as screening technique to estimate the relevance of
methylated arsine emission.
AU - Arndt J
AD - Environmental Geochemistry, Bayreuth Center for Ecology and Environmental
Research (BayCEER), University of Bayreuth, Universitaetsstrasse 30, 95440
Bayreuth, Germany.
AU - Planer-Friedrich B
AD - Environmental Geochemistry, Bayreuth Center for Ecology and Environmental
Research (BayCEER), University of Bayreuth, Universitaetsstrasse 30, 95440
Bayreuth, Germany. Electronic address: b.planer-friedrich@uni-bayreuth.de.
SO - Sci Total Environ. 2018, Jan 01; 610-611:1590-1594. [The Science of the
total environment]
AB - Volatile arsenic (As) species, like arsine, mono-, di-, and
trimethylarsine (AsH3, MeAsH2, Me2AsH, Me3As) are difficult to sample in
remote areas without sophisticated equipment. The application of moss bags
is an easy-to-apply screening technique which has been used for trapping
total (mostly particulate) As from different emission sources before. We
evaluated its potential for additional volatile As species screening. We
found Me2AsH and Me3As in N2 atmosphere to be quantitatively trapped on
the mosses and to be recoverable as their respective pentavalent acids
(and/or oxyanions) when ground mosses were heated for 90min at 90&deg;C in
0.1M HNO3/3% H2O2. MeAsH2 was trapped partially while AsH3 was not
trapped. The most likely mechanism is covalent bonding to the moss
surface. While moss monitoring does not replace more sophisticated
techniques for volatile As sampling, it can easily be used as screening
technique to determine whether besides particulate As volatile methylated
As species could have any relevance in environments with yet unknown As
emissions.
KW - AsH(3)
KW - Biogas
KW - Sphagnum
KW - Trimethylarsine
KW - Volcanic emissions
RN - V1I29R0RJQ
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180504
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20170623
STAT- MEDLINE
DOCNO- medline/28648372

391 - TOXLINE
TI - The possible repositioning of an oral anti-arthritic drug, auranofin, for
Nrf2-activating therapy: The demonstration of Nrf2-dependent
anti-oxidative action using a zebrafish model.
AU - Fuse Y
AD - Department of Molecular and Developmental Biology, Faculty of Medicine,
University of Tsukuba, Tsukuba 305-8575, Japan; Doctoral Program in Biomedical
Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba,
Tsukuba 305-8575, Japan; Japan Society for the Promotion of Science, Japan.
AU - Endo Y
AD - Department of Molecular and Developmental Biology, Faculty of Medicine,
University of Tsukuba, Tsukuba 305-8575, Japan; College of Biological Sciences,
University of Tsukuba, Tsukuba 305-8575, Japan.
AU - Araoi S
AD - Graduate School of Life and Environmental Sciences, University of Tsukuba,
Tsukuba 305-8577, Japan; Life Science Center, Tsukuba Advanced Research Alliance,
University of Tsukuba, Tsukuba 305-8577, Japan.
AU - Daitoku H
AD - Life Science Center, Tsukuba Advanced Research Alliance, University of
Tsukuba, Tsukuba 305-8577, Japan.
AU - Suzuki H
AD - Department of Experimental Pathology, Faculty of Medicine, University of
Tsukuba, Tsukuba 305-8575, Japan.
AU - Kato M
AD - Department of Experimental Pathology, Faculty of Medicine, University of
Tsukuba, Tsukuba 305-8575, Japan.
AU - Kobayashi M
AD - Department of Molecular and Developmental Biology, Faculty of Medicine,
University of Tsukuba, Tsukuba 305-8575, Japan. Electronic address:
makobayash@md.tsukuba.ac.jp.
SO - Free Radic Biol Med. 2018, Feb 01; 115:405-411. [Free radical biology &
medicine]
AB - The Nrf2 pathway is a biological defense system against oxidative stress.
The pharmacological activation of the Nrf2 pathway is a promising therapy
for oxidative stress-related diseases, but it has been challenging to find
an Nrf2 activator with acceptable toxicity. To circumvent this problem, we
focused on an already approved oral anti-arthritic drug, auranofin that
has been reported to have the potential to activate Nrf2. We used a
zebrafish model to investigate whether auranofin has protective action
against oxidative stress in vivo. Auranofin pre-treatment considerably
improved the survival of zebrafish larvae that were challenged with a
lethal dose of hydrogen peroxide. This protective effect was not observed
in an Nrf2 mutant zebrafish strain, suggesting that the activation of the
biological defense against oxidative stress was Nrf2-dependent.
Auranofin-induced protection was further tested by challenges with
redox-active heavy metals. A clear protective effect was observed against
arsenite, a highly redox-reactive toxicant. In addition, this effect was
also demonstrated to be Nrf2-dependent based on the analysis of an Nrf2
mutant strain. These results clearly demonstrate the anti-oxidative action
of auranofin and encourage the repositioning of auranofin as a drug that
improves oxidative stress-related pathology.
KW - Arsenite toxicity
KW - Auranofin-induced protection
KW - Heavy metal
KW - Nrf2 pathway
KW - Oxidative stress
KW - Zebrafish genetics
LA - eng
IS - 1873-4596 (Electronic)
PT - Journal Article
TA - Free Radic Biol Med
YR - 2018
DATE- 20180114
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Free radical biology &amp; medicine
EDAT- 20171219
STAT- In-Data-Review
DOCNO- medline/29277393

392 - TOXLINE
TI - Arsenic removal by periphytic biofilm and its application combined with
biochar.
AU - Zhu N
AD - State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil
Sciences, Chinese Academy of Sciences, 71 East Beijing Road, Nanjing 210008, China;
Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
AU - Zhang J
AD - Resources &amp; Environment Business Dept., International Engineering
Consulting Corporation, Beijing 100048, China.
AU - Tang J
AD - State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil
Sciences, Chinese Academy of Sciences, 71 East Beijing Road, Nanjing 210008, China;
Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
AU - Zhu Y
AD - State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil
Sciences, Chinese Academy of Sciences, 71 East Beijing Road, Nanjing 210008, China;
Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
AU - Wu Y
AD - State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil
Sciences, Chinese Academy of Sciences, 71 East Beijing Road, Nanjing 210008, China.
Electronic address: yhwu@issas.ac.cn.
SO - Bioresour Technol. 2018, Jan; 248(Pt B):49-55. [Bioresource technology]
AB - A biochar and periphyton-based system (BPS) comprising of a biochar column
and a periphyton bioreactor was designed to avoid the toxicity issue
associated with removing As(III) from wastewater. Results showed that the
periphyton can grow when As(III) is less than 5.0mgL-1. The BPS obtained a
high As(III) removal rate (&sim;90.2-95.4%) at flow rate=1.0mLmin-1 and
initial concentration of As(III)=2.0mgL-1. About 60% of the As(III) was
pre-treated (adsorbed) in the biochar column and the removal of the
remaining As(III) was attributed to the periphyton bioreactor. The As(III)
removal process by periphytic biofilm in the initial stage fits a
pseudo-second-kinetic model. The calcite in the periphytic biofilm
surfaces and the OH and CO groups were responsible for the As(III)
removal. This study indicates the feasibility of the BPS for As(III)
removal in practice.
KW - As(III) removal
KW - Biochar
KW - Periphytic biofilm
RN - 16291-96-6
RN - N712M78A8G
LA - eng
IS - 1873-2976 (Electronic)
PT - Journal Article
TA - Bioresour Technol
YR - 2018
DATE- 20180530
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Bioresource technology
EDAT- 20170708
STAT- MEDLINE
DOCNO- medline/28720276

393 - TOXLINE
TI - Decoding the role of hypothetical protein All3255 of Anabaena PCC7120 in
heavy metal stress management in Escherichia coli.
AU - Singh PK
AD - Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh,
221005, India.
AU - Tang M
AD - State Key Laboratory of Cotton Biology, Henan Key Laboratory of Plant Stress
Biology, Henan University, Kaifeng, 475004, Henan, China.
AU - Kumar S
AD - Department of Botany, Banaras Hindu University, Varanasi, Uttar Pradesh,
221005, India.
AU - Shrivastava AK
AD - Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar,
845401, India. alokshrivastava@mgcub.ac.in.
SO - Arch Microbiol. 2018, Apr; 200(3):463-471. [Archives of microbiology]
AB - Cadmium is a non-essential toxic heavy metal for organisms, including
plants and cyanobacteria. Cadmium resistance transporters involved in
resistance of cells against various toxicants such as drugs and effluxes
cytotoxic compounds from cells. However, cadmium resistance-associated
protein (CadD) has never been reported from a diazotrophic cyanobacterium
Anabaena sp. To test whether the hypothetical protein All3255 of Anabaena
sp. PCC7120 a homolog of cadmium resistance-associated protein (CadD)
involved in cadmium or heavy metal resistance or not, cloning and
heterologous expression analysis of all3255 performed in Escherichia coli
BL21 (DE3). Our results revealed that the strain transformed with
pGEX-5X-2&thinsp;+&thinsp;all3255 showed resistant towards not only to
cadmium but also other heavy metals such as nickel, copper, zinc, lead and
cobalt in addition to arsenic than those of transformed with empty vector
(pGEX-5X-2). Furthermore, the results of metal accumulation analysis of
these cells unveil a lower accumulation of tested heavy metals in
all3255-overexpressing E. coli cells than those transformed with empty
vector. This study strongly supports the role of All3255 of Anabaena sp.
PCC7120 as a CadD efflux pump of heavy metals in E.coli.
KW - Anabaena sp. PCC7120
KW - Cadmium resistance transporter (CadD)
KW - Escherichia coli BL21 (DE3)
KW - Heavy metals
KW - Hypothetical proteins
KW - Resistance
RN - 00BH33GNGH
RN - 789U1901C5
RN - N712M78A8G
LA - eng
IS - 1432-072X (Electronic)
PT - Journal Article
TA - Arch Microbiol
YR - 2018
DATE- 20180530
CITO- NLM
CS - Germany
CSET- IM
FJT - Archives of microbiology
EDAT- 20171130
STAT- MEDLINE
DOCNO- medline/29189890

394 - TOXLINE
TI - Assessing the effects of seawater temperature and pH on the
bioaccumulation of emerging chemical contaminants in marine bivalves.
AU - Maulvault AL
AD - Division of Aquaculture and Upgrading (DivAV), Portuguese Institute for the
Sea and Atmosphere (IPMA, I.P.), Lisbon, Portugal; Interdisciplinary Centre of
Marine and Environmental Research (CIIMAR), University of Porto, Porto, Portugal;
MARE - Marine and Environmental Sciences Centre, Faculty of Sciences, University of
Lisbon (FCUL), Lisboa, Portugal. Electronic address: aluisa@ipma.pt.
AU - Camacho C
AD - Division of Aquaculture and Upgrading (DivAV), Portuguese Institute for the
Sea and Atmosphere (IPMA, I.P.), Lisbon, Portugal.
AU - Barbosa V
AD - Division of Aquaculture and Upgrading (DivAV), Portuguese Institute for the
Sea and Atmosphere (IPMA, I.P.), Lisbon, Portugal.
AU - Alves R
AD - Division of Aquaculture and Upgrading (DivAV), Portuguese Institute for the
Sea and Atmosphere (IPMA, I.P.), Lisbon, Portugal.
AU - Anacleto P
AD - Division of Aquaculture and Upgrading (DivAV), Portuguese Institute for the
Sea and Atmosphere (IPMA, I.P.), Lisbon, Portugal; Interdisciplinary Centre of
Marine and Environmental Research (CIIMAR), University of Porto, Porto, Portugal;
MARE - Marine and Environmental Sciences Centre, Faculty of Sciences, University of
Lisbon (FCUL), Lisboa, Portugal.
AU - Foga�a F
AD - EMBRAPA, Embrapa Meio-Norte, Parna�ba, Brazil.
AU - Kwadijk C
AD - Wageningen University &amp; Research, AB Ijmuiden, The Netherlands.
AU - Kotterman M
AD - Wageningen University &amp; Research, AB Ijmuiden, The Netherlands.
AU - Cunha SC
AD - LAQV-REQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy,
University of Porto, Porto, Portugal.
AU - Fernandes JO
AD - LAQV-REQUIMTE, Laboratory of Bromatology and Hydrology, Faculty of Pharmacy,
University of Porto, Porto, Portugal.
AU - Rasmussen RR
AD - National Food Institute, Technical University of Denmark, S�borg, Denmark.
AU - Sloth JJ
AD - National Food Institute, Technical University of Denmark, S�borg, Denmark.
AU - Aznar-Alemany �
AD - Water and Soil Quality Research Group, Department of Environmental Chemistry,
Institute of Environmental Assessment and Water Research, (IDAEA-CSIC), Barcelona,
Spain.
AU - Eljarrat E
AD - Water and Soil Quality Research Group, Department of Environmental Chemistry,
Institute of Environmental Assessment and Water Research, (IDAEA-CSIC), Barcelona,
Spain.
AU - Barcel� D
AD - Water and Soil Quality Research Group, Department of Environmental Chemistry,
Institute of Environmental Assessment and Water Research, (IDAEA-CSIC), Barcelona,
Spain.
AU - Marques A
AD - Division of Aquaculture and Upgrading (DivAV), Portuguese Institute for the
Sea and Atmosphere (IPMA, I.P.), Lisbon, Portugal.
SO - Environ Res. 2018, Feb; 161:236-247. [Environmental research]
AB - Emerging chemical contaminants [e.g. toxic metals speciation, flame
retardants (FRs) and perfluorinated compounds (PFCs), among others], that
have not been historically recognized as pollutants nor their
toxicological hazards, are increasingly more present in the marine
environment. Furthermore, the effects of environmental conditions (e.g.
temperature and pH) on bioaccumulation and elimination mechanisms of these
emerging contaminants in marine biota have been poorly studied until now.
In this context, the aim of this study was to assess, for the first time,
the effect of warmer seawater temperatures (&Delta; = + 4&deg;C) and lower
pH levels (&Delta; = - 0.4 pH units), acting alone or combined, on the
bioaccumulation and elimination of emerging FRs (dechloranes 602, 603 and
604, and TBBPA), inorganic arsenic (iAs), and PFCs (PFOA and PFOS) in two
estuarine bivalve species (Mytilus galloprovincialis and Ruditapes
philippinarum). Overall, results showed that warming alone or combined
with acidification promoted the bioaccumulation of some compounds (i.e.
dechloranes 602, 604, TBBPA), but also facilitated the elimination of
others (i.e. iAs, TBBPA). Similarly, lower pH also resulted in higher
levels of dechloranes, as well as enhanced iAs, PFOA and PFOS elimination.
Data also suggests that, when both abiotic stressors are combined,
bivalves' capacity to accumulate contaminants may be time-dependent,
considering significantly drastic increase observed with Dec 602 and
TBBPA, during the last 10 days of exposure, when compared to reference
conditions. Such changes in contaminants' bioaccumulation/elimination
patterns also suggest a potential increase of human health risks of some
compounds, if the climate continues changing as forecasted. Therefore,
this first study pointed out the urgent need for further research on the
effects of abiotic conditions on emerging contaminants kinetics, to
adequately estimate the potential toxicological hazards associated to
these compounds and develop recommendations/regulations for their presence
in seafood, considering the prevailing environmental conditions expected
in tomorrow's ocean.
KW - Acidification
KW - Bioaccumulation
KW - Emerging chemical contaminants
KW - Flame retardants
KW - Perfluorinated compounds
KW - Toxic elements
KW - Warming
LA - eng
IS - 1096-0953 (Electronic)
PT - Journal Article
TA - Environ Res
YR - 2018
DATE- 20171230
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Environmental research
STAT- In-Data-Review
DOCNO- medline/29169098

395 - TOXLINE
TI - The mechanism of protective effect of crocin against liver mitochondrial
toxicity caused by arsenic III.
AU - Yousefsani BS
AD - a Department of Pharmacodynamy and Toxicology, School of Pharmacy ,
Pharmaceutical Research Center, Mashhad University of Medical Sciences , Mashhad ,
Iran.
AU - Pourahmad J
AD - b Department of Pharmacology and Toxicology, Faculty of Pharmacy , Shahid
Beheshti University of Medical Sciences , Tehran , Iran.
AU - Hosseinzadeh H
AD - a Department of Pharmacodynamy and Toxicology, School of Pharmacy ,
Pharmaceutical Research Center, Mashhad University of Medical Sciences , Mashhad ,
Iran.
SO - Toxicol Mech Methods. 2018, Feb; 28(2):105-114. [Toxicology mechanisms and
methods]
AB - In this study, we want to understand whether crocin could prevent
mitochondrial damage caused by As III. For this purpose, we determined
different mitochondrial toxicity endpoints caused by As III. We evaluated
mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane
potential (MMP) collapse, mitochondrial outer membrane integrity and
cytochrome c release. Our results showed that pretreatment with crocin at
a concentration of 25&thinsp;&micro;g/ml significantly
(p&thinsp; < &thinsp;0.001) reduced As III-induced mitochondrial ROS
formation, lipid peroxidation, MMP collapse and mitochondrial swelling.
Crocin also protected the mitochondria by decreasing the mitochondrial
outer membrane damage that leads to reduce the amount of cytochrome c
release. These results demonstrated that crocin is a promising antidotal
candidate by ameliorating As III-induced oxidative stress through
mitochondrial targeting.
KW - Arsenic (As III)
KW - antioxidant
KW - crocin
KW - hepatoprotection
KW - mitochondrial targeting
KW - oxidative stress
LA - eng
IS - 1537-6524 (Electronic)
PT - Journal Article
TA - Toxicol Mech Methods
YR - 2018
DATE- 20171228
CITO- NLM
CS - England
FJT - Toxicology mechanisms and methods
EDAT- 20170831
STAT- In-Process
DOCNO- medline/28812436

396 - TOXLINE
TI - Assessment of Genotoxic Effects by Constructing a 3D Cellular System with
Highly Sensitive Mutagenic Human-Hamster Hybrid Cells.
AU - Zhang Y
AD - Key Laboratory of Environmental Toxicology and Pollution Control Technology
of Anhui Province , Hefei , Anhui 230031 , China.
AU - Xu S
AD - Key Laboratory of Environmental Toxicology and Pollution Control Technology
of Anhui Province , Hefei , Anhui 230031 , China.
AU - Wu T
AD - Key Laboratory of Environmental Toxicology and Pollution Control Technology
of Anhui Province , Hefei , Anhui 230031 , China.
AU - Hu K
AD - School of Environment Science and Spatial Informatics , China University of
Mining and Technology , Xuzhou 221116 , China.
AU - Chen S
AD - Key Laboratory of Environmental Toxicology and Pollution Control Technology
of Anhui Province , Hefei , Anhui 230031 , China.
AU - Xu A
AD - Key Laboratory of Environmental Toxicology and Pollution Control Technology
of Anhui Province , Hefei , Anhui 230031 , China.
AU - Wu L
AD - Key Laboratory of Environmental Toxicology and Pollution Control Technology
of Anhui Province , Hefei , Anhui 230031 , China.
SO - Chem Res Toxicol. 2018, Jun 19. [Chemical research in toxicology]
AB - Owing to complex microenvironmental conditions, it is challenging to
reflect the actual biological responses of tissues or the body in a
two-dimensional (2D) cellular system. In the present study, a
low-attachment-cultivation technique was employed to establish a highly
sensitive 3D human-hamster hybrid (AL) model to study the mutagenic
effects of environmental pollutants. The results showed that the
established 3D system has apparent organizational characteristics. The
average diameter and average cell number of the 3D cells were
approximately 240 &mu;m and 1500, respectively. The expression of stemness
and cell-junction genes (biomarkers for 3D cells) was higher than that in
2D cells. The present study analyzed the mutagenic effects of the
environmental carcinogens arsenite and silver nanoparticles using the
established 3D system to demonstrate its efficiency in mutagenic
assessment. The results showed that the mutagenic effects of arsenite (10
&mu;M) and silver nanoparticles (10 &mu;g/mL) were 70 &plusmn; 3 and 99
&plusmn; 7 per 105 survivors, respectively. These values were much lower
than those from 2D AL cells and comparable to those from the in vivo
system. These results suggest that the developed 3D-cell-culture model
based on the 2D AL cellular system more effectively reflects the actual
gene-mutation frequency of mutagens in vivo.
LA - eng
IS - 1520-5010 (Electronic)
PT - Journal Article
TA - Chem Res Toxicol
YR - 2018
DATE- 20180619
CITO- NLM
CS - United States
FJT - Chemical research in toxicology
EDAT- 20180619
STAT- Publisher
DOCNO- medline/29882401

397 - TOXLINE
TI - An in vitro cytotoxic approach to assess the toxicity of heavy metals and
their binary mixtures on hippocampal HT-22 cell line.
AU - Karri V
AD - Environmental Engineering Laboratory, Departament d'Enginyeria Quimica,
Universitat Rovira i Virgili, Av. Pa�sos Catalans 26, 43007 Tarragona, Spain.
AU - Kumar V
AD - Environmental Engineering Laboratory, Departament d'Enginyeria Quimica,
Universitat Rovira i Virgili, Av. Pa�sos Catalans 26, 43007 Tarragona, Spain.
Electronic address: vikas.kumar@urv.cat.
AU - Ramos D
AD - Plataforma de Prote�mica, Parc Cient�fic de Barcelona, C/Baldiri Reixac, 10-
12, 08028, Barcelona, Spain.
AU - Oliveira E
AD - Unidad de Toxicologia, Parc Cient�fic de Barcelona, C/Baldiri Reixac, 10-12,
08028, Barcelona, Spain.
AU - Schuhmacher M
AD - Environmental Engineering Laboratory, Departament d'Enginyeria Quimica,
Universitat Rovira i Virgili, Av. Pa�sos Catalans 26, 43007 Tarragona, Spain.
SO - Toxicol Lett. 2018, Jan 05; 282:25-36. [Toxicology letters]
AB - Humans are exposed to a cocktail of heavy metal toxicants in the
environment. Though heavy metals are deleterious, there is a paucity of
information on the toxicity of mixtures. In this study, four common
neurotoxicity heavy metals lead (Pb) cadmium (Cd), arsenic (As), and
methylmercury (MeHg) were exposed individually and as mixtures to HT-22
cell line for 8days. The study established that low dose exposures induced
toxicity to the HT-22 cell line during 8days. The results indicates
potency dependent response, the toxicity of single metals on the HT-22
cells; MeHg > As > Cd > Pb. The cytotoxicity data of single
metals were used to determine the mixtures interaction profile by using
the dose additivity and effect additivity method. Metal mixtures showed
higher toxicities compared to individual metals. Synergistic, antagonistic
or additive effects of the toxicity were observed in different mixtures in
low dose exposure. The interactive responses of mixtures depend on the
co-exposure metal and their respective concentration. We concluded that
the combined effects should be considered in the risk assessment of heavy
metal co-exposure and potency. In future, comprehensive mechanistic based
investigations needed for understanding the real interactive mixtures
effects at molecular level.
KW - Apoptosis
KW - Cytotoxicity
KW - Isobologram analysis
KW - Metal mixtures
KW - Mixture toxicity
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20171201
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Toxicology letters
EDAT- 20171005
STAT- MEDLINE
DOCNO- medline/28988819

398 - TOXLINE
TI - Investigations of water-extractability of As in excavated urban soils
using sequential leaching tests: Effect of testing parameters.
AU - Li J
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan; Research Fellow of Japan
Society for the Promotion of Science, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083,
Japan. Electronic address: ljn006.edu@gmail.com.
AU - Kosugi T
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan.
AU - Riya S
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan.
AU - Hashimoto Y
AD - Department of Bioapplications and Systems Engineering (BASE), Tokyo
University of Agriculture and Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588,
Japan.
AU - Hou H
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Dayangfang 8, Beijing 100012, PR China.
AU - Terada A
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan.
AU - Hosomi M
AD - Department of Chemical Engineering, Tokyo University of Agriculture and
Technology, 2-24-16 Naka, Koganei, Tokyo 184-8588, Japan. Electronic address:
hosomi@cc.tuat.ac.jp.
SO - J Environ Manage. 2018, Jul 01; 217:297-304. [Journal of environmental
management]
AB - Excavated soils with low-level As contamination obtained from construction
projects during city development have been of great concern in Japan.
Water-extractable As represents the most easily mobilized and
ecotoxicologically relevant fraction in the soil environment. In the
present study, the water-extractability of As in excavated alkaline urban
soils was assessed using sequential leaching tests (SLTs) with a focus on
the effects of test parameters. In addition, the potentially
water-leachable As over an extremely long period was assessed using the
pollution potential leaching index (PPLI), from which one can estimate the
number of extractions required to reduce the As in the cumulative
leachates to below the Japanese environmental standard
(10&#8239;&mu;g&#8239;L-1). Total As concentrations varied from 6.75 to
79.4&#8239;mg&#8239;kg-1, and As was continuously detectable among
replicate SLT experiments. The water-extractable As obtained in the first
step of the SLT accounted for 0.41%-7.60% of total As (average: 2.36%),
while the cumulative released As in the SLTs corresponded to 1.30%-21.6%
of the total (average: 10.6%). The variability of the water-soluble
fractions was sensitive to the test conditions. The shaking time at each
SLT step had the largest effect on the As water-extractability; followed
by sample storage, shaking speed and shaking interruption. A longer
shaking time in the standard leaching test of excavated soils is suggested
for regulatory purposes in Japan. The use of the PPLI concept for quick
estimation of the potential As leachability from excavated soils was
supported by the good reproducibility of PPLI results obtained from SLTs
under different test parameters.
KW - Arsenic
KW - Excavated urban soils
KW - Sequential leaching test
KW - Water-extractability
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180430
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180405
STAT- In-Process
DOCNO- medline/29614478

399 - TOXLINE
TI - Effect of long-term aerobic, anaerobic and aerobic-anaerobic physical
training in seric toxic minerals concentrations.
AU - Maynar-Mari�o M
AD - Department of Physiology, School of Sport Sciences, University of
Extremadura, University Avenue, C�ceres, C�ceres, 0071, Spain. Electronic address:
mmaynarm@gmail.com.
AU - Llerena F
AD - Department of Medical-Surgical Therapeutics, School of Medicine, University
of Extremadura, Elvas Avenue, Badajoz, Badajoz, 06071, Spain.
AU - Bartolom� I
AD - Department of Physiology, School of Sport Sciences, University of
Extremadura, University Avenue, C�ceres, C�ceres, 0071, Spain.
AU - Crespo C
AD - Department of Physiology, School of Sport Sciences, University of
Extremadura, University Avenue, C�ceres, C�ceres, 0071, Spain.
AU - Mu�oz D
AD - Department of Medical-Surgical Therapeutics, School of Medicine, University
of Extremadura, Elvas Avenue, Badajoz, Badajoz, 06071, Spain.
AU - Robles MC
AD - Department of Medical-Surgical Therapeutics, School of Medicine, University
of Extremadura, Elvas Avenue, Badajoz, Badajoz, 06071, Spain.
AU - Caballero MJ
AD - Department of Medical-Surgical Therapeutics, School of Medicine, University
of Extremadura, Elvas Avenue, Badajoz, Badajoz, 06071, Spain.
SO - J Trace Elem Med Biol. 2018, Jan; 45:136-141. [Journal of trace elements
in medicine and biology : organ of the Society for Minerals and Trace
Elements (GMS)]
AB - BACKGROUND: Many substances poured out from industries can be toxic to
humans and can impair physical performance. Besides, physical training may
modify the body concentrations of these substances as a result of
physiological adaptations.
AB - OBJECTIVES: The aim of the study was to determine if different modalities
of exercise might affect serum concentrations of toxic trace elements in
sportsmen.
AB - METHODS: 80 Spanish national sportsmen were recruited before the start of
their training period. All the athletes had been training regularly for
the previous two years with a rigorous training target at high-level
competition. 31 sedentary participants from the same geographic area
formed the control group. Serum arsenic, beryllium, cadmium, cesium and
lead samples were analyzed with an ICP-MS.
AB - RESULTS: Serum concentrations were higher among the sportsmen group than
among the control group, being highly significant in cases of Be from
0.043&plusmn;0.019 to 0.074&plusmn;0.029&mu;g/L, Cs from
0.693&plusmn;0.305 to 1.358&plusmn;0.569&mu;g/L and Pb from
0.162&plusmn;0.171 to 2.375&plusmn;1.699&mu;g/L; and significant in the
case of Cd from 0.046&plusmn;0.027 to 0.067&plusmn;0.059&mu;g/L. However,
if they were separated according to different sport modalities, it was
found that, although they had higher concentrations than controls, there
were elements that changed their concentrations in relation to the
metabolic type of activity performed.
AB - CONCLUSIONS: In some cases physical exercise induces favorable adaptations
to avoid environmental pollution damage. Endurance training (65-75%
VO2max) can be considered the most effective exercise to prevent toxicity
effects. However, integral-matrixes analysis are required in further
research to overcome some controversial behaviors of some elements.
KW - Energetic metabolism
KW - Performance
KW - Serum
KW - Toxic minerals
KW - Toxicity
KW - Training
LA - eng
IS - 1878-3252 (Electronic)
PT - Journal Article
TA - J Trace Elem Med Biol
YR - 2018
DATE- 20171127
CI - Copyright &copy; 2017 Elsevier GmbH. All rights reserved.
CITO- NLM
CS - Germany
FJT - Journal of trace elements in medicine and biology : organ of the Society
for Minerals and Trace Elements (GMS)
EDAT- 20171018
STAT- In-Process
DOCNO- medline/29173470

400 - TOXLINE
TI - Manganese in blood cells as an exposure biomarker in manganese-exposed
workers healthy cohort.
AU - Ge X
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Wang F
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Zhong Y
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Lv Y
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Jiang C
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Zhou Y
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Li D
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Xia B
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Su C
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Cheng H
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China.
AU - Ma Y
AD - Department of Toxicology, School of Public Health, Guangxi Medical
University, Nanning 530021, China.
AU - Xiong F
AD - Department of Toxicology, School of Public Health, Guangxi Medical
University, Nanning 530021, China.
AU - Shen Y
AD - Department of Neurology, The First Affiliated Hospital of Guangxi Medical
University, Nanning 530021, China.
AU - Zou Y
AD - Department of Toxicology, School of Public Health, Guangxi Medical
University, Nanning 530021, China.
AU - Yang X
AD - Department of Occupational Health and Environmental Health, School of Public
Health, Guangxi Medical University, Nanning 530021, China; Center for Genomic and
Personalized Medicine, Guangxi Medical University, Nanning 530021, China.
Electronic address: yxbo21021@163.com.
SO - J Trace Elem Med Biol. 2018, Jan; 45:41-47. [Journal of trace elements in
medicine and biology : organ of the Society for Minerals and Trace
Elements (GMS)]
AB - Elevated exposure to manganese (Mn) has long been a public health concern.
However, there is currently no consensus on the best exposure biomarker.
Here we aimed to investigate the exposomic characteristics of plasma
metals among Mn-exposed workers and explore the potential biomarkers of Mn
exposure in the blood pool. First, total sixteen plasma metals (Calcium,
Magnesium, Iron, Zinc, Copper, Selenium, Lead, Chromium, Arsenic,
Manganese, Nickel, Molybdenum, Cadmium, Mercury, Thallium, and Cobalt)
were determined among 40 occupationally Mn-exposed subjects. Second, Mn
levels in both plasma and blood cells were detected among 234 workers from
the manganese-exposed workers healthy cohort (MEWHC), respectively.
Analysis of plasma metal exposome showed that the plasma Mn concentrations
were positively correlated to plasma Fe (r=0.361), Ni (r=0.363), Cr
(r=0.486), and Hg (r=0.313) (all p < 0.05). Mn concentrations in plasma
were not significantly correlated to external exposure levels
(ptrend=0.200), and it was further confirmed among the 234 subjects
(ptrend=0.452). However, Mn concentrations in blood cells progressively
increased as the external exposure dose increased (low-exposure group vs
high-exposure group, median 11.53&mu;g/L vs 20.41&mu;g/L, ptrend=0.001).
Our results suggest that Mn in blood cells, but not plasma, could serve as
a potential internal exposure biomarker. Larger validation studies are
needed to establish the utility of this biomarker.
KW - Biomarkers
KW - Blood cells
KW - Exposome
KW - Manganese
KW - Plasma
LA - eng
IS - 1878-3252 (Electronic)
PT - Journal Article
TA - J Trace Elem Med Biol
YR - 2018
DATE- 20171127
CI - Copyright &copy; 2017. Published by Elsevier GmbH.
CITO- NLM
CS - Germany
FJT - Journal of trace elements in medicine and biology : organ of the Society
for Minerals and Trace Elements (GMS)
EDAT- 20170919
STAT- In-Process
DOCNO- medline/29173481

401 - TOXLINE
TI - Bioaccessibility assessment of toxic and essential elements in produced
pulses, Bahia, Brazil.
AU - Santos WPC
AD - Instituto Federal de Educa��o, Ci�ncia e Tecnol�gica da Bahia, Campus
Salvador, Departamento de Qu�mica, 40300-010, Salvador, BA, Brazil. Electronic
address: wagna.ifba@gmail.com.
AU - Ribeiro NM
AD - Instituto Federal de Educa��o, Ci�ncia e Tecnol�gica da Bahia, Campus
Salvador, Departamento de Qu�mica, 40300-010, Salvador, BA, Brazil.
AU - Santos DCMB
AD - Universidade Federal da Bahia, Instituto de Qu�mica, Campus Universit�rio de
Ondina Salvador, 40170-115 Salvador, Bahia, Brazil.
AU - Korn MGA
AD - Universidade Federal da Bahia, Instituto de Qu�mica, Campus Universit�rio de
Ondina Salvador, 40170-115 Salvador, Bahia, Brazil.
AU - Lopes MV
AD - Universidade do Estado da Bahia, Campus Cabula, 41.150-000 Salvador, BA,
Brazil.
SO - Food Chem. 2018, Feb 01; 240:112-122. [Food chemistry]
AB - The objective of this study was to analyze the effect of heat treatment on
the bioaccessibility of major (K, Ca, Mg, P) and trace elements (As, Ba,
Cu, Fe, Mn, Cd, Cr, Hg, Mo, Ni, Pb, Se, Sb, Sn, and Zn) in three different
pulse species: Vigna unguiculata L. Walp (cowpea beans), Cajanus cajan L.
(pigeon pea) and Lablab purpureus L. Sweet (mangalo). Analyte
concentrations were determined in the samples by inductively coupled
plasma mass spectrometry and inductively coupled plasma optical emission
spectrometry. The results showed that thermal processing can affect the
concentrations of the elements investigated in pulse samples. The
influence of the heat treatment can range between legume species and
chemical elements, as well as with the type of heat treatment, dry, wet,
conductive heating and using microwaves.
KW - Arsenic (PubChem CID: 5359596)
KW - Barium (PubChem CID: 5355457)
KW - Bioaccessibility
KW - Cadmium (PubChem CID: 23973)
KW - Calcium (PubChem CID: 5460341)
KW - Copper (PubChem CID: 23978)
KW - Essential and toxic elements
KW - Heat treatment
KW - Iron (PubChem CID: 23925)
KW - Magnesium (PubChem CID: 5462224)
KW - Manganese (PubChem CID: 23930)
KW - Pulses
KW - Traces elements
KW - Zinc (PubChem CID: 23994)
RN - FXS1BY2PGL
LA - eng
IS - 0308-8146 (Print)
PT - Journal Article
TA - Food Chem
YR - 2018
DATE- 20171113
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Food chemistry
EDAT- 20170711
STAT- MEDLINE
DOCNO- medline/28946232

402 - TOXLINE
TI - Environmental Influences on the Epigenome: Exposure- Associated DNA
Methylation in Human Populations.
AU - Martin EM
AD - Department of Environmental Sciences and Engineering, and Curriculum in
Toxicology, Gillings School of Global Public Health, University of North Carolina,
Chapel Hill, North Carolina 27599, USA; email: emsebas@live.unc.edu , rfry@unc.edu.
AU - Fry RC
AD - Department of Environmental Sciences and Engineering, and Curriculum in
Toxicology, Gillings School of Global Public Health, University of North Carolina,
Chapel Hill, North Carolina 27599, USA; email: emsebas@live.unc.edu , rfry@unc.edu.
SO - Annu Rev Public Health. 2018, Apr 01; 39:309-333. [Annual review of public
health]
AB - DNA methylation is the most well studied of the epigenetic regulators in
relation to environmental exposures. To date, numerous studies have
detailed the manner by which DNA methylation is influenced by the
environment, resulting in altered global and gene-specific DNA
methylation. These studies have focused on prenatal, early-life, and adult
exposure scenarios. The present review summarizes currently available
literature that demonstrates a relationship between DNA methylation and
environmental exposures. It includes studies on aflatoxin B1, air
pollution, arsenic, bisphenol A, cadmium, chromium, lead, mercury,
polycyclic aromatic hydrocarbons, persistent organic pollutants, tobacco
smoke, and nutritional factors. It also addresses gaps in the literature
and future directions for research. These gaps include studies of
mixtures, sexual dimorphisms with respect to environmentally associated
methylation changes, tissue specificity, and temporal stability of the
methylation marks.
KW - environment
KW - epigenetics
KW - human studies
KW - molecular epidemiology
LA - eng
IS - 1545-2093 (Electronic)
PT - Journal Article
TA - Annu Rev Public Health
YR - 2018
DATE- 20180402
CITO- NLM
CS - United States
FJT - Annual review of public health
EDAT- 20180112
STAT- In-Data-Review
DOCNO- medline/29328878

403 - TOXLINE
TI - Remediation of arsenic(III) from aqueous solutions using zero-valent iron
(ZVI) combined with potassium permanganate and ferrous ions.
AU - Deng W
AD - Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal
University, Tianjin 300387, China E-mail: liutingyi@tju.edu.cn.
AU - Zhou Z
AD - Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal
University, Tianjin 300387, China E-mail: liutingyi@tju.edu.cn.
AU - Zhang X
AD - Baoding Environmental Monitoring Center of Hebei Province, Baoding 071000,
China.
AU - Yang Y
AD - Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal
University, Tianjin 300387, China E-mail: liutingyi@tju.edu.cn.
AU - Sun Y
AD - Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal
University, Tianjin 300387, China E-mail: liutingyi@tju.edu.cn.
AU - Wang Y
AD - Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal
University, Tianjin 300387, China E-mail: liutingyi@tju.edu.cn.
AU - Liu T
AD - Tianjin Key Laboratory of Water Resources and Environment, Tianjin Normal
University, Tianjin 300387, China E-mail: liutingyi@tju.edu.cn.
SO - Water Sci Technol. 2018, Jan; 77(1-2):375-386. [Water science and
technology : a journal of the International Association on Water Pollution
Research]
AB - A system of zerovalent iron combined with potassium permanganate and
ferrous irons (Fe(II)-KMnO4-ZVI) was used to remove As(III), one of the
most poisonous wastewater pollutants. The Fe(II)-KMnO4-ZVI system was
characterized by using X-ray photoelectron spectroscopy and scanning
electron microscopy. The As(III) removal efficiency by the
Fe(II)-KMnO4-ZVI system under different conditions was investigated and
the experimental data were fitted to adsorption kinetics and isotherm
models. As(III) could be removed by both physisorption and chemisorption
through mixing adsorbents in a very short time (minute scale) with high
removal ratios (more than 99.5%) over a wide range of pH (1-9) and
concentration (20-100 mg/L). The removal of As(III) by the
Fe(II)-KMnO4-ZVI system agreed well with pseudo-first-order reaction
kinetics and pseudo-second-order reaction kinetics. The Freundlich
isotherm provided a good model of the adsorption system, indicating that
the Fe(II)-KMnO4-ZVI system has heterogeneous structure. The results show
that the Fe(II)-KMnO4-ZVI system exhibited a high removal efficiency for
As(III), which suggested that it might be an effective material for
As(III) remediation.
RN - 00OT1QX5U4
RN - E1UOL152H7
LA - eng
IS - 0273-1223 (Print)
PT - Journal Article
TA - Water Sci Technol
YR - 2018
DATE- 20180426
CITO- NLM
CS - England
CSET- IM
FJT - Water science and technology : a journal of the International Association
on Water Pollution Research
STAT- MEDLINE
DOCNO- medline/29377822

404 - TOXLINE
TI - Development of an in vitro toxicological test system based on zebrafish
(Danio rerio) sperm analysis.
AU - Koll�r T
AD - Department of Aquaculture, Szent Istv�n University, P�ter K�roly u. 1.,
G�d�ll&#337;, H-2100, Hungary.
AU - K�sa E
AD - Department of Aquaculture, Szent Istv�n University, P�ter K�roly u. 1.,
G�d�ll&#337;, H-2100, Hungary.
AU - Ferincz �
AD - Department of Aquaculture, Szent Istv�n University, P�ter K�roly u. 1.,
G�d�ll&#337;, H-2100, Hungary.
AU - Urb�nyi B
AD - Department of Aquaculture, Szent Istv�n University, P�ter K�roly u. 1.,
G�d�ll&#337;, H-2100, Hungary.
AU - Csenki-Bakos Z
AD - Department of Aquaculture, Szent Istv�n University, P�ter K�roly u. 1.,
G�d�ll&#337;, H-2100, Hungary. Csenki.Zsolt@mkk.szie.hu.
AU - Horv�th �
AD - Department of Aquaculture, Szent Istv�n University, P�ter K�roly u. 1.,
G�d�ll&#337;, H-2100, Hungary. Horvath.Akos@mkk.szie.hu.
SO - Environ Sci Pollut Res Int. 2018, May; 25(15):14426-14436. [Environmental
science and pollution research international]
AB - The effect of seven heavy metals on the motility parameter of zebrafish
sperm was tested in order to develop an in vitro toxicological test system
as an alternative to live animal testing. In vitro test systems are
currently preferred in ecotoxicology due to their practical and ethical
advantages and fish sperm can be a suitable model. A number of studies had
been carried out previously on this topic, but the described methods had
not been standardized in numerous aspects (donor species, measured
endpoint, etc.). In this study, heavy metals (mercury, arsenic, chromium,
zinc, nickel, copper, cadmium) were used as reference toxicants with known
toxicity to develop a standardized fish sperm in vitro assay. The tested
concentrations were determined based on preliminary range finding tests.
The endpoints were progressive motility (PMOT, %), curvilinear velocity
(VCL, &mu;m/s), and linearity (LIN, %) measured by a computer-assisted
sperm analysis (CASA) system. According to our results, PMOT was the most
sensitive of the three investigated parameters: dose-response curves were
observed for each metal at relatively low concentrations. VCL values were
less sensitive: higher concentrations were needed to observe changes. Of
the three parameters, LIN was the least affected: dose-response
relationship was observed only in the case of mercury (e.g., lowest
observed effect concentration (LOEC) of Hg at 120 min: 1 mg/L
for PMOT, 2.5 mg/L for VCL, 5 mg/L for LIN; LOEC of Cu at
120 min: 1 mg/L for PMOT, 5 mg/L for VCL, any for LIN). The
order of toxicity as determined by PMOT was as follows:
Hg2+&thinsp; > &thinsp;As3+&thinsp; > &thinsp;Cd2+&thinsp; >
&thinsp;Cu2+&thinsp; > &thinsp;Zn2+&thinsp; > &thinsp;Cr3+&thinsp; >
&thinsp;Ni2+.
In conclusion, we found that PMOT of zebrafish sperm was an accurate and
fast bioindicator of heavy metal load. Sperm analysis can be adopted to
estimate the possible toxic effects of various chemicals in vitro. Future
investigations should concentrate on the applicability of this assay to
other contaminants (e.g., organic pollutants).
KW - CASA
KW - Heavy metals
KW - In vitro
KW - LIN
KW - Progressive motility
KW - Sperm
KW - VCL
KW - Zebrafish
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180531
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180310
STAT- In-Process
CM - Cites: Ecotoxicol Environ Saf. 2012 Oct;84:293-8 (medline /22889497)
CM - Cites: PLoS One. 2015 Dec 30;10(12):e0146021 (medline /26717316)
CM - Cites: Comp Biochem Physiol C Toxicol Pharmacol. 2011 May;153(4):422-9
(medline /21349348)
CM - Cites: Chem Biol Interact. 2010 Dec 5;188(3):473-7 (medline /20836996)
CM - Cites: Chemosphere. 2010 Jul;80(5):530-4 (medline /20466407)
CM - Cites: Aquat Toxicol. 2010 May 10;97(4):277-84 (medline /20044150)
CM - Cites: Ecotoxicology. 2012 Nov;21(8):2419-29 (medline /22732941)
CM - Cites: Ecotoxicology. 2017 Dec;26(10 ):1314-1326 (medline /29127661)
CM - Cites: Biol Bull. 1974 Aug;147(1):236-46 (medline /4210846)
CM - Cites: Environ Monit Assess. 2006 Nov;122(1-3):101-9 (medline /16738765)
CM - Cites: Arch Environ Contam Toxicol. 2000 May;38(4):455-63 (medline
/10787096)
CM - Cites: Environ Technol. 2001 Apr;22(4):439-45 (medline /11329806)
CM - Cites: Environ Toxicol Chem. 2003 Jun;22(6):1295-301 (medline /12785587)
CM - Cites: Arch Environ Contam Toxicol. 2014 Oct;67(3):297-309 (medline
/24862981)
CM - Cites: PLoS One. 2013 Jun 03;8(6):e65282 (medline /23755209)
CM - Cites: J Exp Biol. 2015 Apr 15;218(Pt 8):1116-21 (medline /25714567)
CM - Cites: Aquat Toxicol. 2011 Oct;105(3-4):385-93 (medline /21820385)
CM - Cites: Reprod Biol. 2009 Nov;9(3):295-301 (medline /19997481)
CM - Cites: Chem Biol Interact. 2013 Apr 25;203(2):377-85 (medline /23376258)
CM - Cites: Ecotoxicol Environ Saf. 2010 Oct;73(7):1588-95 (medline /20537390)
CM - Cites: Mar Pollut Bull. 2002 Jul;44(7):583-9 (medline /12222880)
CM - Cites: Aquat Toxicol. 2003 Nov 19;65(3):309-16 (medline /13678849)
CM - Cites: Mycotoxin Res. 2017 Nov;33(4):297-308 (medline /28741250)
CM - Cites: Theriogenology. 2007 Feb;67(3):661-72 (medline /17137620)
CM - Cites: Aquat Toxicol. 2011 Oct;105(3-4):355-60 (medline /21819815)
CM - Cites: Ecotoxicol Environ Saf. 2016 Jan;123:53-9 (medline /26318919)
CM - Cites: Comp Biochem Physiol C Toxicol Pharmacol. 2001 Dec;130(4):425-33
(medline /11738630)
CM - Cites: J Exp Zool. 1982 Jul 20;222(1):81-8 (medline /7119705)
CM - Cites: Aquat Toxicol. 2014 Jul;152:273-83 (medline /24800870)
CM - Cites: Cell Biol Toxicol. 2013 Feb;29(1):59-73 (medline /23224722)
CM - Cites: Pak J Biol Sci. 2007 Sep 1;10(17):2862-7 (medline /19090189)
CM - Cites: Sci Total Environ. 1999 Jan 12;225(1-2):3-11 (medline /10028699)
DOCNO- medline/29525864

405 - TOXLINE
TI - Evidence of transboundary mercury and other pollutants in the
Puyango-Tumbes River basin, Ecuador-Peru.
AU - Marshall BG
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Veiga MM
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Kaplan RJ
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Adler Miserendino R
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Schudel G
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Bergquist BA
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Guimar�es JRD
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Sobral LGS
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
AU - Gonzalez-Mueller C
AD - Norman B. Keevil Institute of Mining Engineering, University of British
Columbia, 517-6350 Stores Road, Vancouver, B.C. V6T 1Z4, Canada.
bruce.marshall@ubc.ca.
SO - Environ Sci Process Impacts. 2018, Apr 25; 20(4):632-641. [Environmental
science. Processes & impacts]
AB - In Portovelo in southern Ecuador, 87 gold processing centers along the
Puyango-Tumbes River produce an estimated 6 tonnes of gold per annum using
a combination of mercury amalgamation and/or cyanidation and processing
poly-metallic ores. We analysed total Hg, Hg isotopes, total arsenic,
cadmium, copper, lead and zinc in water and sediment along the Puyango in
2012-2014. The highest total mercury (THg) concentrations in sediments
were found within a 40 km stretch downriver from the processing plants,
with levels varying between 0.78-30.8 mg kg-1 during the dry season and
1.80-70.7 mg kg-1 during the wet season, with most concentrations above
the CCME (Canadian Council of Ministers of the Environment) Probable
Effect Level (PEL) of 0.5 mg kg-1. Data from mercury isotopic analyses
support the conclusion that mercury use during gold processing in
Portovelo is the source of Hg pollution found downstream in the Tumbes
Delta in Peru, 160 km away. The majority of the water and sediment samples
collected from the Puyango-Tumbes River had elevated concentrations of,
arsenic, cadmium, copper, lead and zinc exceeding the CCME thresholds for
the Protection of Aquatic Life. At monitoring points immediately below the
processing plants, total dissolved concentrations of these metals exceeded
the thresholds by 156-3567 times in surface waters and by 19-740 times in
sediment. The results illustrate a significant transboundary pollution
problem involving Hg and other toxic metals, amplified by the fact that
the Puyango-Tumbes River is the only available water source in the
semi-arid region of northern Peru.
LA - eng
IS - 2050-7895 (Electronic)
PT - Journal Article
TA - Environ Sci Process Impacts
YR - 2018
DATE- 20180427
CITO- NLM
CS - England
FJT - Environmental science. Processes &amp; impacts
STAT- In-Process
DOCNO- medline/29492485

406 - TOXLINE
TI - Association between serum heavy metals level and cancer incidence in
darbandikhan and Kalar Area, Kurdistan Region, Iraq.
AU - Marouf BH
AD - Department of Pharmacology and Toxicology, Faculty of Medical Sciences,
School of Pharmacy, University of Sulaimani, Kurdistan, Iraq.
SO - Niger J Clin Pract. 2018, Jun; 21(6):766-771. [Nigerian journal of
clinical practice]
AB - Background: : Exposure to heavy metals is considered as the main threat to
human health and biological system. Darbandikhan Lake is one of the three
large lakes in Kurdistan, Northern Iraq; it is currently at a high risk of
pollution by sewage and municipal wastes. The current study was designed
to highlight the potential association between concentration of heavy
metals and carcinogenicity in people who live in Darbandikhan and the
surrounding area.
AB - Materials and Methods: : A case-control study was carried out on 29
cancerous patients and 25 healthy individuals from Darbandikhan, Kalar,
and the surrounding area; the patients were admitted to the Hiwa Oncology
Center in Sulaimani City. Determination of serum concentrations of copper
(Cu), iron (Fe), cadmium (Cd), arsenic (As), chromium (Cr), lead (Pb), and
zinc (Zn), was performed by an inductively coupled plasma atomic
absorption spectrophotometer.
AB - Results: : Serum concentration of Pb, Fe, and Cu was higher in cancer
group compared with control in nonsignificantly different (P > 0.05)
for Pb, whereas significantly (P < 0.05) for Cu and Fe. Higher serum Cd
concentration was detected in control group compared with the cancer
group. Differences not detected in Cr and As serum concentration analysis
between both groups. Serum level of Zn was nonsignificantly higher in
control group compared with the cancer group (P > 0.05).
AB - Conclusion: Discrepancies in the serum level of heavy metals of cancer
group might reveal the involvement of heavy metal as a contributing factor
of carcinogenicity in these areas.
COI - There are no conflicts of interest
KW - Cancer
KW - Darbandikhan
KW - Kalar
KW - heavy metals
KW - water sources
LA - eng
IS - 1119-3077 (Print)
PT - Journal Article
TA - Niger J Clin Pract
YR - 2018
DATE- 20180611
CITO- NLM
CS - India
FJT - Nigerian journal of clinical practice
STAT- In-Process
DOCNO- medline/29888725

407 - TOXLINE
TI - Realgar transforming solution suppresses angiogenesis and tumor growth by
inhibiting VEGF receptor 2 signaling in vein endothelial cells.
AU - Song P
AD - Key Laboratory of Prevention and Treatment for Chronic Disease by Traditional
Chinese Medicine of Gansu Province, Jiayuguan West Road No. 732, Lanzhou, 730000,
China.
AU - Hai Y
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Wang X
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Zhao L
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Chen B
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Cui P
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Xie Q
AD - School of Life Sciences, Institute of Microbiology, Lanzhou University,
Tianshui Road No. 222, Lanzhou, 730000, China.
AU - Yu L
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Li Y
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Wu Z
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China.
AU - Li H
AD - School of Pharmacy, Lanzhou University, Donggang Road No. 199, Lanzhou,
730000, China. lihy@lzu.edu.cn.
SO - Arch Pharm Res. 2018, Apr; 41(4):467-480. [Archives of pharmacal research]
AB - Realgar (As4S4), as an arsenic sulfide mineral drug, has a good
therapeutic reputation for anticancer in Traditional Chinese Medicine, and
has recently been reported to inhibit angiogenesis in tumor growth.
However, considering the poor solubility and low bioavailability of
realgar, large dose of realgar and long period of treatment are necessary
for achieving the effective blood medicine concentration. In present
study, we resolved the crucial problem of poor solubility of realgar by
using intrinsic biotransformation in microorganism, and investigated
underlying mechanisms of realgar transforming solution (RTS) for
antiangiogenesis. Our results demonstrated that RTS had a strong activity
to inhibit HUVECs proliferation, migration, invasion, and tube formation.
Moreover, RTS inhibited VEGF/bFGF-induced phosphorylation of VEGFR2 and
the downstream protein kinases including ERK, FAK, and Src. In vivo
zebrafish and chicken chorioallantoic membrane model experiments showed
that RTS remarkably blocked angiogenesis. Finally, compared with the
control, administration of 2.50 mg/kg RTS reached more than 50%
inhibition against H22 tumor allografts in KM mice, but caused few toxic
effects in the host. The antiangiogenic effect was indicated by CD31
immunohistochemical staining and alginate-encapsulated tumor cell assay.
In summary, our findings suggest that RTS inhibits angiogenesis and may be
a potential drug candidate in anticancer therapy.
KW - Angiogenesis
KW - Realgar transforming solution
KW - Tumor growth
KW - VEGF receptor 2
KW - Vein endothelial cell
LA - eng
IS - 0253-6269 (Print)
PT - Journal Article
TA - Arch Pharm Res
YR - 2018
DATE- 20180425
CITO- NLM
CS - Korea (South)
FJT - Archives of pharmacal research
EDAT- 20180315
STAT- In-Process
DOCNO- medline/29542005

408 - TOXLINE
TI - Underutilized and Under Threat: Environmental Policy as a Tool to Address
Diabetes Risk.
AU - Shaikh S
AD - Program on Global Environment, Social Science Collegiate Division, University
of Chicago, Chicago, IL, USA.
AU - Jagai JS
AD - Environmental and Occupational Health Sciences Division, School of Public
Health, University of Illinois at Chicago, Chicago, IL, USA.
AU - Ashley C
AD - Harris School of Public Policy, University of Chicago, Chicago, IL, USA.
AU - Zhou S
AD - Harris School of Public Policy, University of Chicago, Chicago, IL, USA.
AU - Sargis RM
AD - Division of Endocrinology, Diabetes and Metabolism, Department of Medicine,
University of Illinois at Chicago, 835 S. Wolcott; Suite E625, Chicago, IL, 60612,
USA. rsargis@uic.edu.
SO - Curr Diab Rep. 2018, Mar 26; 18(5):25. [Current diabetes reports]
AB - PURPOSE OF REVIEW: Diabetes is a burgeoning threat to public health in the
USA. Importantly, the burden of diabetes is not equally borne across
society with marked disparities based on geography, race/ethnicity, and
income. The etiology of global and population-specific diabetes risk
remains incompletely understood; however, evidence linking environmental
toxicants acting as endocrine-disrupting chemicals (EDCs), such as
particulate matter and arsenic, with diabetes suggests that environmental
policies could play an important role in diabetes risk reduction.
AB - RECENT FINDINGS: Evidence suggests that disproportionate exposures to EDCs
may contribute to subgroup-specific diabetes risk; however, no federal
policies regulate EDCs linked to diabetes based upon diabetogenic
potential. Nevertheless, analyses of European Union data indicate that
such regulation could reduce diabetes-associated costs and disease burden.
Federal laws only regulate EDCs indirectly. The accumulating evidence
linking these chemicals with diabetes risk should encourage policymakers
to adopt stricter environmental standards that consider both health and
economic impacts.
KW - Diabetes
KW - Endocrine-disrupting chemical
KW - Environmental justice
KW - Environmental policy
KW - Pollution
KW - Toxicant
LA - eng
IS - 1539-0829 (Electronic)
PT - Journal Article
PT - Review
TA - Curr Diab Rep
YR - 2018
DATE- 20180425
CITO- NLM
CS - United States
FJT - Current diabetes reports
EDAT- 20180326
STAT- In-Data-Review
CM - Cites: Environ Health Perspect. 2010 Sep;118(9):1235-42 (medline
/20444671)
CM - Cites: Hypertension. 2016 Jan;67(1):77-85 (medline /26573709)
CM - Cites: Annu Rev Public Health. 2006;27:103-24 (medline /16533111)
CM - Cites: Am J Epidemiol. 2008 Apr 1;167(7):847-58 (medline /18192277)
CM - Cites: Environ Int. 2015 Jul;80:26-32 (medline /25863281)
CM - Cites: Circulation. 2012 Feb 14;125(6):767-72 (medline /22219348)
CM - Cites: PLoS One. 2009 Oct 19;4(10):e7503 (medline /19838294)
CM - Cites: Environ Health Perspect. 2009 Jul;117(7):1076-82 (medline
/19654916)
CM - Cites: Curr Diab Rep. 2013 Dec;13(6):814-23 (medline /24037313)
CM - Cites: Diabetes Care. 2013 Apr;36(4):1033-46 (medline /23468086)
CM - Cites: Environ Pollut. 2016 Oct;217:124-33 (medline /26846187)
CM - Cites: Diabetes. 2011 Jul;60(7):1838-48 (medline /21709279)
CM - Cites: Environ Health Perspect. 2013 Feb;121(2):153-61 (medline /23131992)
CM - Cites: Diabetes Care. 2018 Jan;41(1):193-205 (medline /29142003)
CM - Cites: Bioethics. 2007 May;21(4):230-41 (medline /17845481)
CM - Cites: Lancet Public Health. 2017 Nov;2(11):e513-e521 (medline /29250608)
CM - Cites: Am J Prev Med. 2011 Apr;40(4):434-9 (medline /21406277)
CM - Cites: Toxicol Appl Pharmacol. 2006 Jul 1;214(1):30-4 (medline /16413591)
CM - Cites: Environ Health Perspect. 2012 Dec;120(12 ):1658-70 (medline
/22889723)
CM - Cites: J Epidemiol Community Health. 2017 Feb;71(2):111-114 (medline
/27789757)
CM - Cites: Curr Environ Health Rep. 2017 Jun;4(2):208-222 (medline /28432637)
CM - Cites: J Epidemiol Community Health. 2014 Feb;68(2):176-84 (medline
/24133074)
CM - Cites: Diabetes Care. 2014;37(5):1279-86 (medline /24574350)
CM - Cites: Endocrinology. 2012 Sep;153(9):4097-110 (medline /22733974)
CM - Cites: Am J Epidemiol. 2001 Jun 1;153(11):1031-44 (medline /11390319)
CM - Cites: Biomed Res Int. 2015;2015:368087 (medline /26000288)
CM - Cites: Endocr Rev. 2009 Jun;30(4):293-342 (medline /19502515)
CM - Cites: Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R294-R303
(medline /29118024)
CM -Cites: Environ Health Perspect. 2010 Sep;118(9):1273-9 (medline /20504758)
CM -Cites: Environ Sci Technol. 2013 Sep 3;47(17):10032-40 (medline /23885945)
CM -Cites: Circ Res. 2015 Jan 2;116(1):108-15 (medline /25348167)
CM -Cites: Environ Health Perspect. 2010 Jun;118(6):864-70 (medline /20100676)
CM -Cites: Toxicol Appl Pharmacol. 2008 Sep 15;231(3):291-9 (medline
/18597805)
CM - Cites: Sci Total Environ. 2013 Mar 15;448:66-71 (medline /22901427)
CM - Cites: Toxicol Appl Pharmacol. 2013 Feb 15;267(1):11-5 (medline /23261974)
CM - Cites: Environ Health. 2015 Jun 19;14:53 (medline /26087770)
CM - Cites: Endocrinology. 2015 Dec;156(12):4458-73 (medline /26465197)
CM - Cites: BMC Health Serv Res. 2006 Oct 03;6:124 (medline /17018153)
CM - Cites: Endocrinology. 2016 Sep;157(9):3469-81 (medline /27560547)
CM - Cites: Endocr Rev. 2015 Dec;36(6):E1-E150 (medline /26544531)
CM - Cites: Am J Epidemiol. 2015 Mar 1;181(5):327-36 (medline /25693777)
CM - Cites: Occup Environ Med. 2014 Sep;71(9):629-35 (medline /24727735)
CM - Cites: Diabetes Care. 2011 Aug;34(8):1778-84 (medline /21700918)
CM - Cites: Lancet Public Health. 2017 Nov;2(11):e488-e489 (medline /29253371)
CM - Cites: Diabetologia. 2013 Aug;56(8):1696-704 (medline /23666166)
CM - Cites: Diabetes Care. 2013 Oct;36(10):3313-20 (medline /23780947)
DOCNO- medline/29582168

409 - TOXLINE
TI - Impact assessment of fly ash on ground water quality: An experimental
study using batch leaching tests.
AU - Dandautiya R
AD - Civil Engineering Department, Birla Institute of Technology and Science,
Pilani, India.
AU - Singh AP
AD - Civil Engineering Department, Birla Institute of Technology and Science,
Pilani, India.
AU - Kundu S
AD - Civil Engineering Department, Birla Institute of Technology and Science,
Pilani, India.
SO - Waste Manag Res. 2018, May 01:734242X18775484. [Waste management &
research : the journal of the International Solid Wastes and Public
Cleansing Association, ISWA]
AB - The fly ash, generated at the coal-based thermal power plant, is always a
cause of concern to environmentalists owing to its adverse impact on air,
water and land. There exists a high environmental risk when it is disposed
to the environment. Thus, two different type of fly ash samples (FA-1 and
FA-2) have been considered in this study to examine the leaching potential
of the elements magnesium, aluminium, silicon, calcium, titanium,
vanadium, chromium, manganese, iron, nickel, cobalt, copper, zinc,
arsenic, selenium, strontium, cadmium, barium and lead for different types
of leachant. Toxicity characteristics leaching procedure and ASTM tests
have been performed in the laboratory to simulate different natural
leaching scenarios. Characterisation of samples have been done through
X-ray diffraction and field emission gun scanning electron microscope. The
effect of different liquid to solid ratios (i.e. 5, 10, 20 and 50) on the
mobilisation of elements has been analysed. The results indicated that the
maximum leaching of all elements occurred at a liquid to solid ratio of 5
except for arsenic, barium and silicon. The groundwater analysis has also
been done to understand the actual effects of leachate. The elements
presenting the highest leachability in the two fly ash samples under all
tested conditions were magnesium, aluminium, silicon and calcium. It has
been observed that calcium exhibits greater leaching effects than all
other constituents. The study presented here has been found very useful
for assessing contamination levels in groundwater owing to leaching
effects of fly ash under different scenarios, which can be helpful to
prevent spreading of the contaminants by efficient management of fly ash.
KW - Groundwater
KW - fly ash
KW - inductively coupled plasma mass spectrometry test
KW - leaching
KW - toxicity characteristics leaching procedure
LA - eng
IS - 1096-3669 (Electronic)
PT - Journal Article
TA - Waste Manag Res
YR - 2018
DATE- 20180531
CITO- NLM
CS - England
FJT - Waste management &amp; research : the journal of the International Solid
Wastes and Public Cleansing Association, ISWA
EDAT- 20180501
STAT- Publisher
DOCNO- medline/29848219

410 - TOXLINE
TI - An Adult Zebrafish Diet Contaminated with Chromium Reduces the Viability
of Progeny.
AU - Tye MT
AD - 1 Zebrafish Core Facility, University of Minnesota Twin-Cities , Minneapolis,
Minnesota.
AU - Montgomery JE
AD - 2 Department of Neuroscience, University of Minnesota Twin-Cities ,
Minneapolis, Minnesota.
AU - Hobbs MR
AD - 3 Centralized Zebrafish Animal Resource, University of Utah , Salt Lake City,
Utah.
AU - Vanpelt KT
AD - 2 Department of Neuroscience, University of Minnesota Twin-Cities ,
Minneapolis, Minnesota.
AU - Masino MA
AD - 2 Department of Neuroscience, University of Minnesota Twin-Cities ,
Minneapolis, Minnesota.
SO - Zebrafish. 2018, 04; 15(2):179-187. [Zebrafish]
AB - The lack of standardized diet for laboratory animals can have profound
effects on animal health and lead to less reproducible research outcomes.
Live diets are commonly used in zebrafish culture and, although they are a
more natural feed than flake or pellet food, are also a potential source
of pathogens and toxic compounds. Heavy metals are a group of such
compounds, which can accumulate in fish leading to developmental
abnormalities, reduced growth, and increased rates of mortality. Two to
three weeks after feeding adult zebrafish a new lot of nonhatching
decapsulated brine shrimp cysts (Decaps), embryos at the University of
Minnesota Zebrafish Core Facility (ZCF) and the University of Utah
Centralized Zebrafish Animal Resource (CZAR) began to exhibit an orange
color in the yolk, and larval health began to decline. The concentration
of chromium in the Decaps (69.6&thinsp;mg/kg) was more than 30 times that
of other zebrafish diets tested (up to 2.1&thinsp;mg/kg) and is thought to
be the cause of the observed symptoms. Within 3 weeks of removing the
Decaps from the feeding regimen, the orange coloration in the yolks began
to diminish, the morphological abnormalities began to subside, and larval
survival rates began to increase. Thus, implementation of standardized
zebrafish diets and regular feed-quality testing may help to prevent the
introduction of contaminants to zebrafish research facilities.
KW - *arsenic
KW - *barium
KW - *brine shrimp
KW - *chromium
KW - *diet
KW - *zebrafish
LA - eng
IS - 1557-8542 (Electronic)
PT - Journal Article
TA - Zebrafish
YR - 2018
DATE- 20180424
CITO- NLM
CS - United States
FJT - Zebrafish
EDAT- 20180102
STAT- In-Process
CM - Cites: Oecologia. 1987 Aug;73(1):91-98 (medline /28311410)
CM - Cites: Bull Environ Contam Toxicol. 2016 Mar;96(3):341-6 (medline
/26758458)
CM - Cites: Cell Stem Cell. 2008 Feb 7;2(2):183-9 (medline /18371439)
CM - Cites: Natl Toxicol Program Tech Rep Ser. 2008 Jul;(546):1-192 (medline
/18716633)
CM - Cites: Zebrafish. 2015 Dec;12(6):457-61 (medline /25495227)
CM - Cites: Arch Environ Contam Toxicol. 2000 Apr;38(3):283-97 (medline
/10667925)
CM - Cites: Aquat Toxicol. 2016 Jul;176:208-16 (medline /27162070)
CM - Cites: Fish Physiol Biochem. 2009 Nov;35(4):625-40 (medline /19020985)
CM - Cites: Fundam Appl Toxicol. 1992 Nov;19(4):527-37 (medline /1426711)
CM - Cites: Ecotoxicol Environ Saf. 2016 Mar;125:78-84 (medline /26680530)
CM - Cites: Aquat Toxicol. 2002 May;57(3):153-66 (medline /11891004)
CM - Cites: Comp Biochem Physiol C Toxicol Pharmacol. 2010 Sep;152(3):338-45
(medline /20566315)
CM - Cites: ILAR J. 2012;53(2):144-60 (medline /23382346)
CM - Cites: Zebrafish. 2016 Oct;13(5):405-12 (medline /27140519)
CM - Cites: J Appl Toxicol. 1993 May-Jun;13(3):217-24 (medline /8326093)
CM - Cites: Aquat Toxicol. 2014 Jul;152:152-63 (medline /24768856)
CM - Cites: J Toxicol Clin Toxicol. 1999;37(2):173-94 (medline /10382554)
CM - Cites: Arch Environ Contam Toxicol. 1991 Nov;21(4):518-27 (medline
/1759847)
CM - Cites: Toxicol Appl Pharmacol. 2007 Jun 15;221(3):329-38 (medline
/17499830)
CM - Cites: Aquat Toxicol. 2009 Feb 19;91(3):229-37 (medline /19110324)
CM - Cites: Aquat Toxicol. 2016 Feb;171:59-68 (medline /26748265)
CM - Cites: Environ Health Perspect. 1995 Dec;103 Suppl 9:23-34 (medline
/8635436)
CM - Cites: Toxicol Appl Pharmacol. 2004 May 1;196(3):431-7 (medline /15094314)
CM - Cites: Rev Environ Contam Toxicol. 1993;130:31-77 (medline /8419988)
CM - Cites: Comp Med. 2002 Aug;52(4):354-8 (medline /12211280)
DOCNO- medline/29293412

411 - TOXLINE
TI - From sea squirts to squirrelfish: facultative trace element
hyperaccumulation in animals.
AU - Thompson ED
AD - Department of Biological Sciences, Northern Kentucky University, SC 245 Nunn
Dr Highland Heights, KY 41099, USA. thompsone1@nku.edu.
AU - Hogstrand C
AD - Faculty of Life Sciences and Medicine, King's College London, UK.
AU - Glover CN
AD - Faculty of Science and Technology and Athabasca River Basin Research
Institute, Athabasca University, Canada and Department of Biological Sciences,
University of Alberta, Canada.
SO - Metallomics. 2018, May 31. [Metallomics : integrated biometal science]
AB - The hyperaccumulation of trace elements is a widely characterized
phenomenon in plants, bacteria, and fungi, but has received little
attention in animals. However, there are numerous examples of animals that
specifically and facultatively accumulate trace elements in the absence of
elevated environmental concentrations. Metal hyperaccumulating animals are
usually marine invertebrates, likely owing to environmental (e.g. constant
exposure via the water) and physiological (e.g. osmoconforming and reduced
integument permeability) factors. However, there are examples of
terrestrial animals (insect larvae) and marine vertebrates (e.g.
squirrelfish) that accumulate high body and/or tissue metal burdens. This
review examines examples of animal hyperaccumulation of the elements
arsenic, copper, iron, titanium, vanadium and zinc, describing mechanisms
by which accumulation occurs and, where possible, hypothesizing functional
roles. Groups such as the ascidians (sea squirts), molluscs (gastropods,
bivalves and cephalopods) and polychaete annelids feature prominently as
animals with hyperaccumulating capacity. Many of these species are
potential model organisms offering insight into fundamental processes
underlying metal handling, with relevance to human disease and aquatic
metal toxicity, and some offer promise in applied fields such as
bioremediation.
LA - eng
IS - 1756-591X (Electronic)
PT - Journal Article
PT - Review
TA - Metallomics
YR - 2018
DATE- 20180531
CITO- NLM
CS - England
FJT - Metallomics : integrated biometal science
EDAT- 20180531
STAT- Publisher
DOCNO- medline/29850752

412 - TOXLINE
TI - Bioaccumulation and trophic transfer of metals, As and Se through a
freshwater food web affected by antrophic pollution in C�rdoba,
Argentina.
AU - Griboff J
AD - ICYTAC, Instituto de Ciencia y Tecnolog�a de Alimentos C�rdoba, CONICET and
Facultad de Ciencias Qu�micas, Universidad Nacional de C�rdoba, Bv. Dr. Juan Filloy
s/n, Ciudad Universitaria, 5000 C�rdoba, Argentina.
AU - Horacek M
AD - BLT Wieselburg, HBLFA Francisco-Josephinum, Rottenhauserstrasse, 1, 3250
Wieselburg, Austria; Institute of Lithospheric Research, Vienna University,
Althanstr. 14, 1090 Vienna, Austria.
AU - Wunderlin DA
AD - ICYTAC, Instituto de Ciencia y Tecnolog�a de Alimentos C�rdoba, CONICET and
Facultad de Ciencias Qu�micas, Universidad Nacional de C�rdoba, Bv. Dr. Juan Filloy
s/n, Ciudad Universitaria, 5000 C�rdoba, Argentina.
AU - Monferran MV
AD - ICYTAC, Instituto de Ciencia y Tecnolog�a de Alimentos C�rdoba, CONICET and
Facultad de Ciencias Qu�micas, Universidad Nacional de C�rdoba, Bv. Dr. Juan Filloy
s/n, Ciudad Universitaria, 5000 C�rdoba, Argentina. Electronic address:
mmonferran@fcq.unc.edu.ar.
SO - Ecotoxicol Environ Saf. 2018, Feb; 148:275-284. [Ecotoxicology and
environmental safety]
AB - The concentration of metals (Al, Cr, Mn, Fe, Ni, Cu, Zn, Ag, Cd, Hg, Pb,
U), As and Se in different ecosystem components (water, sediment,
plankton, shrimp, and fish muscle) has been determined in a eutrophic
reservoir in the Province of C�rdoba (Argentina). Los Molinos Lake
(LML) was sampled during the dry (DS) and wet seasons (WS) in order to
examine the bioaccumulation and transfer of these inorganic elements
through the food web. Stable nitrogen isotope (&delta;15N) was used to
investigate trophic interactions. According to this, samples were divided
into three categories: plankton, shrimp (Palaemonetes argentinus) and fish
(Silverside, Odontesthes bonariensis). The bioaccumulation factor (BAF)
was calculated for the organisms, and it was determined that the elements
analyzed undergo bioaccumulation, especially in organisms such as
plankton. The invertebrates were characterized by the highest BAF for Cu
and Zn in both seasons, As (DS), and Cd and Hg (WS). The fish muscle was
characterized by the highest BAF for Se (WS), Ag and Hg (DS). On the other
hand, a significant decrease in Al, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Cd and
U concentrations through the analyzed trophic web during both seasons was
observed. Moreover, a significant increase in Hg levels was observed with
increasing trophic levels in the DS, indicating its biomagnification.
Despite the increasing impact of metals, As and Se pollution in the
studied area due to urban growth and agricultural and livestock
activities, no previous study has focused on the behavior and
relationships of these pollutants with the biotic and abiotic components
of this aquatic reservoir. We expect that these findings may be used for
providing directions or guidance for future monitoring and environmental
protection policies.
KW - Aquatic organisms
KW - As
KW - Biomagnification
KW - Food web
KW - Metals
KW - Stable isotopes
RN - H6241UJ22B
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180615
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171106
STAT- MEDLINE
DOCNO- medline/29078130

413 - TOXLINE
TI - Simultaneous exposure of sulphur and calcium hinder As toxicity:
Up-regulation of growth, mineral nutrients uptake and antioxidants system.
AU - Singh R
AD - Ranjan Plant Physiology and Biochemistry Laboratory, Department of Botany,
University of Allahabad, Allahabad 211002, India. Electronic address:
rachanaranjansingh@gmail.com.
AU - Parihar P
AD - Ranjan Plant Physiology and Biochemistry Laboratory, Department of Botany,
University of Allahabad, Allahabad 211002, India. Electronic address:
parulprhr336@gmail.com.
AU - Prasad SM
AD - Ranjan Plant Physiology and Biochemistry Laboratory, Department of Botany,
University of Allahabad, Allahabad 211002, India. Electronic address:
profsmprasad@gmail.com.
SO - Ecotoxicol Environ Saf. 2018, Jun 08; 161:318-331. [Ecotoxicology and
environmental safety]
AB - The current study was carried out to investigate the role of exogenous
sulphur (K2SO4: S; 60&#8239;mg&#8239;S&#8239;kg-1 sand) and calcium
(CaCl2: Ca; 250&#8239;mg Ca&#8239;kg-1 sand) individually as well as in
combination (S + Ca) in ameliorating the inhibitory effect of As
(Na2HAsO4&middot;7H2O: As1; 15&#8239;mg As&#8239;kg-1 sand and As2;
30&#8239;mg As&#8239;kg-1 sand) by analyzing biomass accumulation, mineral
nutrients uptake, photosynthetic pigments content, redox status of the
cell, enzymatic and non-enzymatic defense system in Brassica juncea
L. seedlings. Biomass accumulation, uptake of mineral nutrients,
photosynthetic pigments (chlorophyll a, b and carotenoids) content and the
activity of proline dehydrogenase (ProDH) declined with increasing
accumulation of As in root as well as leaves in As dose dependent manner.
Contrary to this, exogenous application of S, Ca and S + Ca, markedly
reduced the negative impact of As on above captioned traits except ProDH
activity. On the other hand, ROS and their biomarkers (superoxide radical;
O&#8322;&#729;-, hydrogen peroxide; H2O2, malondialdehyde; MDA equivalents
content and membrane damage; electrolyte leakage), activities of enzymatic
(superoxide dismutase; SOD, peroxidase; POD, catalase; CAT and
glutathione-S-transferase; GST) and non-enzymatic antioxidant i.e. proline
(Pro) content and its enzyme pyrroline-5-carboxylate synthetase; P5CS
activity were increased in root and leaves under As stress. While,
exogenous application of S, Ca and S + Ca, further enhanced the activities
of above mentioned enzymes and Pro content thereby causing considerable
reduction in O&#8322;&#729;-, H2O2, MDA equivalents content and
electrolyte leakage. This study suggests that exogenous application of S
and/or Ca efficiently (particularly S + Ca) lowered the negative impact of
As on biomass accumulation in Brassica seedlings by improving the uptake
of essential mineral nutrients', content of photosynthetic pigments,
activities of enzymatic and content of non-enzymatic antioxidants.
KW - Antioxidant system
KW - Arsenic
KW - Calcium
KW - Mineral nutrients
KW - Oxidative stress
KW - Sulphur
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180608
STAT- Publisher
DOCNO- medline/29890433
414 - TOXLINE
TI - Health risk assessment of heavy metals in freshwater fish in the central
and eastern North China.
AU - Zhong W
AD - Key Laboratory of Pollution Processes and Environmental Criteria of Ministry
of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering of Nankai University,
Tianjin 300350, China.
AU - Zhang Y
AD - Key Laboratory of Pollution Processes and Environmental Criteria of Ministry
of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering of Nankai University,
Tianjin 300350, China.
AU - Wu Z
AD - Key Laboratory of Pollution Processes and Environmental Criteria of Ministry
of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering of Nankai University,
Tianjin 300350, China.
AU - Yang R
AD - Key Laboratory of Pollution Processes and Environmental Criteria of Ministry
of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering of Nankai University,
Tianjin 300350, China.
AU - Chen X
AD - Key Laboratory of Pollution Processes and Environmental Criteria of Ministry
of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering of Nankai University,
Tianjin 300350, China.
AU - Yang J
AD - Key Laboratory of Pollution Processes and Environmental Criteria of Ministry
of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering of Nankai University,
Tianjin 300350, China.
AU - Zhu L
AD - Key Laboratory of Pollution Processes and Environmental Criteria of Ministry
of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution
Control, College of Environmental Science and Engineering of Nankai University,
Tianjin 300350, China. Electronic address: zhuly@nankai.edu.cn.
SO - Ecotoxicol Environ Saf. 2018, Aug 15; 157:343-349. [Ecotoxicology and
environmental safety]
AB - The distribution and potential health risks of eight heavy metals (Copper
(Cu), Chromium (Cr), Zinc (Zn), Lead (Pb), Arsenic (As), Cadmium (Cd),
Manganese (Mn), Nickel (Ni)) in 16 freshwater systems from central and
eastern North China, were investigated. The fish were divided as wild
fish, which grew naturally without artificially feeding, and farmed fish.
The total concentrations of the eight heavy metals ranged from 82.9 to
226&#8239;&mu;g/L in the surface water samples and 3.32-27.6&#8239;mg/kg
dw in the fish samples. There was no significant difference in the heavy
metal concentrations between natural and farmed water systems. The
concentrations of toxic metals, including Pb, As, Cd, Cr, are similar in
all kinds of fish. However, the essential metals (Zn, Cu, Mn, Ni) in
crucian carp (15.9&#8239;mg/kg) was much higher than other kinds of fish.
Comparing the wild and farmed fish, the average concentrations of each
heavy metal in wild crucian carp, bighead carp, grass carp were higher
than those in farmed fish. The average log BCFs (bioconcentration factor)
of Zn, Cr and Cu were the highest (2.14, 2.04, 2.00&#8239;L/kg) while that
of Cd (0.65&#8239;L/kg) was the lowest. The non-carcinogenic and
carcinogenic health risks to adults and children resulting from consuming
the fish were assessed based on the target hazard quotients (THQ). The
results indicated that the non-carcinogenic health risk to humans by
consuming fish products, no matter wild or farmed fish, was relatively
low. The carcinogenic risk of inorganic As was
5.11&#8239;&times;&#8239;10-6-1.95&#8239;&times;&#8239;10-4 for children
and 2.71&#8239;&times;&#8239;10-6-1.04&#8239;&times;&#8239;10-4 for adult,
which are within the acceptable range. The results indicated that the
concentrations of heavy metals in the freshwater fish in central and
eastern North China were relatively low, and did not cause considerable
human health risks.
KW - Farmed fish
KW - Freshwater
KW - Heavy metals
KW - Human health risk
KW - Wild fish
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180424
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180406
STAT- In-Process
DOCNO- medline/29627419

415 - TOXLINE
TI - Anticancer drugs-related QTc prolongation, torsade de pointes and sudden
death: current evidence and future research perspectives.
AU - Duan J
AD - Division of Cardiology, Department of Internal Medicine, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China.
AU - Tao J
AD - Division of Cardiology, Department of Internal Medicine, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China.
AU - Zhai M
AD - Division of Cardiology, Department of Internal Medicine, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China.
AU - Li C
AD - Department of Cardiology, Wuhan Hospital of Integrated Traditional Chinese
and Western Medicine, Wuhan, P.R. China.
AU - Zhou N
AD - Division of Cardiology, Department of Internal Medicine, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China.
AU - Lv J
AD - Division of Cardiology, Department of Internal Medicine, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China.
AU - Wang L
AD - Division of Cardiology, Department of Internal Medicine, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China.
AU - Lin L
AD - Division of Cardiology, Department of Internal Medicine, Tongji Hospital,
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R.
China.
AU - Bai R
AD - Texas Cardiac Arrhythmia Institute at St. David's Medical Center, Austin, TX,
USA.
SO - Oncotarget. 2018, May 22; 9(39):25738-25749. [Oncotarget]
AB - Anticancer drugs may have proarrhythmic effects including drug-induced QT
interval prolongation, which is of particular importance because it can
lead to a fatal polymorphic ventricular tachycardia termed torsade de
pointes (TdP). QT interval prolongation and TdP are rare life-threatening
untoward effects of anticancer therapy, particularly with arsenic
trioxides and anthracyclines, and even some novel molecular targeted drugs
touted as 'tumor specific'. Several factors that affect myocardial
repolarization can further increase the risk of TdP. This article reviews
the mechanism of QT interval prolongation, risk factors for TdP and the QT
toxicity of anticancer drugs as well as its management. Specific attention
should be paid to high-risk populations such as patients with underlying
heart diseases, electrolyte imbalance and bradycardia. To minimize the
occurrence of QT interval prolongation and TdP, it is advisable to conduct
a careful risk factor assessment before antitumor therapy. To this end,
several new biomarkers have been introduced to predict TdP triggering and
recent studies have pointed out the potential clinical relevance of
genetic testing.
COI - CONFLICTS OF INTEREST The author states no conflict of interest.
KW - QT interval prolongation
KW - anticancer therapy
KW - molecularly targeted drugs
KW - torsade de pointes
LA - eng
IS - 1949-2553 (Electronic)
PT - Journal Article
PT - Review
TA - Oncotarget
YR - 2018
DATE- 20180610
CITO- NLM
CS - United States
FJT - Oncotarget
EDAT- 20180522
STAT- PubMed-not-MEDLINE
CM - Cites: Pharmacol Res. 2010 Nov;62(5):384-90 (medline /20674746)
CM - Cites: Jpn J Clin Oncol. 2004 May;34(5):262-8 (medline /15231861)
CM - Cites: Recent Results Cancer Res. 2014;201:197-205 (medline /24756793)
CM - Cites: Swiss Med Wkly. 2007 Oct 6;137(39-40):556-8 (medline /17990147)
CM - Cites: Case Rep Hematol. 2017;2017:4027908 (medline /28326207)
CM - Cites: J Altern Complement Med. 2006 Dec;12(10):1011-4 (medline /17212573)
CM - Cites: Clin Cancer Res. 2010 Jan 15;16(2):664-72 (medline /20068097)
CM - Cites: Am J Cardiol. 2013 Nov 1;112(9):1379-83 (medline /23972343)
CM - Cites: J Am Coll Cardiol. 2007 Jan 23;49(3):320-8 (medline /17239713)
CM - Cites: J Intern Med. 2006 Jan;259(1):59-69 (medline /16336514)
CM - Cites: Drug Saf. 2013 May;36(5):295-316 (medline /23620167)
CM - Cites: J Am Coll Cardiol. 2009 Mar 17;53(11):982-91 (medline /19281931)
CM - Cites: Clin Toxicol (Phila). 2009 Jul;47(6):592-4 (medline /19586358)
CM - Cites: J Clin Oncol. 2001 Sep 15;19(18):3852-60 (medline /11559723)
CM - Cites: Eur J Pharmacol. 2013 Apr 5;705(1-3):1-10 (medline /23474023)
CM - Cites: Circulation. 2003 Oct 21;108(16):1985-9 (medline /14517173)
CM - Cites: Arch Mal Coeur Vaiss. 1966 Feb;59(2):263-72 (medline /4956181)
CM - Cites: Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4474-81 (medline /17671132)
CM - Cites: Eur J Pharmacol. 2000 Oct 6;406(1):25-32 (medline /11011028)
CM - Cites: Br J Cancer. 2015 Jan 20;112(2):296-305 (medline /25349964)
CM - Cites: Heart Rhythm. 2006 Sep;3(9):1003-7 (medline /16945790)
CM - Cites: Circulation. 2010 Mar 2;121(8):1047-60 (medline /20142454)
CM - Cites: Ann Noninvasive Electrocardiol. 2008 Oct;13(4):401-20 (medline
/18973498)
CM - Cites: Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):96-100 (medline /14734457)
CM - Cites: Tex Heart Inst J. 2010;37(2):218-20 (medline /20401299)
CM - Cites: Lancet Oncol. 2016 Dec;17 (12 ):1643-1652 (medline /27751847)
CM - Cites: Clin Cardiol. 2009 Dec;32(12 ):E80-4 (medline /20014213)
CM - Cites: J Clin Oncol. 2010 Dec 10;28(35):5174-81 (medline /21060028)
CM - Cites: Basic Res Cardiol. 2007 Jan;102(1):42-51 (medline /16817026)
CM - Cites: Heart Rhythm. 2014 Mar;11(3):485-91 (medline /24252288)
CM - Cites: Clin Cancer Res. 2009 Nov 15;15(22):7045-52 (medline /19903787)
CM - Cites: Haematologica. 2012 Jun;97(6):883-9 (medline /22271904)
CM - Cites: Clin Transl Oncol. 2008 May;10(5):298-9 (medline /18490248)
CM - Cites: Nat Rev Cardiol. 2010 Oct;7(10):564-75 (medline /20842180)
CM - Cites: N Engl J Med. 2004 Mar 4;350(10):1013-22 (medline /14999113)
CM - Cites: Can J Cardiol. 2016 Jul;32(7):863-870.e5 (medline /27117975)
CM - Cites: Circulation. 2004 Jan 6;109(1):26-9 (medline /14691044)
CM - Cites: Pacing Clin Electrophysiol. 2001 Apr;24(4 Pt 1):474-85 (medline
/11341085)
CM - Cites: J Electrocardiol. 1992;25 Suppl:131-6 (medline /1297679)
CM - Cites: Circ Arrhythm Electrophysiol. 2011 Aug;4(4):441-7 (medline
/21593198)
CM - Cites: Pacing Clin Electrophysiol. 2001 Apr;24(4 Pt 1):515-7 (medline
/11341093)
CM - Cites: Ann Pharmacother. 2012 Oct;46(10):1340-8 (medline /22968522)
CM - Cites: J Am Coll Cardiol. 2011 Sep 20;58(13):1309-24 (medline /21920259)
CM - Cites: Tumori. 2013 Nov-Dec;99(6):288e-92e (medline /24503806)
CM - Cites: Eur J Pharmacol. 2011 Jan 10;650(1):335-41 (medline /21034734)
CM - Cites: Blood. 2001 Mar 1;97(5):1514-6 (medline /11222403)
CM - Cites: Anticancer Res. 2014 Jul;34(7):3243-9 (medline /24982327)
CM - Cites: Clin Ther. 2008 Nov;30(11):1956-75 (medline /19108785)
CM - Cites: Cardiovasc Res. 2012 Oct 1;96(1):90-8 (medline /22853924)
CM - Cites: Biol Pharm Bull. 2013;36(2):268-75 (medline /23196655)
CM - Cites: Prog Cardiovasc Dis. 2010 Sep-Oct;53(2):105-13 (medline /20728697)
CM - Cites: BMC Pharmacol Toxicol. 2013 Jan 14;14:7 (medline /23316779)
CM - Cites: Leuk Lymphoma. 2013 Sep;54(9):1996-2002 (medline /23256542)
CM - Cites: Oncologist. 2014 Oct;19(10):e5-11 (medline /25170012)
CM - Cites: Int J Hematol. 2006 May;83(4):318-23 (medline /16757431)
CM - Cites: J Pharmacol Toxicol Methods. 2012 Sep;66(2):135-44 (medline
/22445855)
CM - Cites: Drug Saf. 2015 Oct;38(10):855-67 (medline /26108299)
CM - Cites: Cancer J. 2014 Jan-Feb;20(1):18-24 (medline /24445759)
CM - Cites: J Altern Complement Med. 2013 Dec;19(12):973-5 (medline /23841836)
CM - Cites: Invest New Drugs. 2013 Aug;31(4):900-9 (medline /23143778)
CM - Cites: Curr Drug Saf. 2010 Jan;5(1):93-6 (medline /20210725)
CM - Cites: Oncologist. 2012;17(7):917-24 (medline /22673631)
CM - Cites: ScientificWorldJournal. 2012;2012:212178 (medline /22593664)
CM - Cites: Circulation. 1991 Sep;84(3):1136-44 (medline /1884444)
CM - Cites: Heart Rhythm. 2007 May;4(5):603-7 (medline /17467628)
CM - Cites: Clin Cancer Res. 2006 Jul 1;12(13):3997-4003 (medline /16818698)
CM - Cites: Basic Clin Pharmacol Toxicol. 2010 Jul;107(1):614-8 (medline
/20406211)
CM - Cites: J Clin Oncol. 2003 Oct 1;21(19):3609-15 (medline /14512391)
CM - Cites: Int J Cancer. 2012 Aug 1;131(3):E304-11 (medline /22065400)
CM - Cites: Oncotarget. 2015 Nov 3;6(34):35589-601 (medline /26431495)
CM - Cites: Pharmacol Rep. 2009 Jan-Feb;61(1):154-71 (medline /19307704)
CM - Cites: N Engl J Med. 2016 Oct 13;375(15):1457-1467 (medline /27732808)
CM - Cites: Naunyn Schmiedebergs Arch Pharmacol. 2003 Jul;368(1):41-8 (medline
/12827215)
CM - Cites: Curr Pharm Biotechnol. 2007 Dec;8(6):388-400 (medline /18289048)
CM - Cites: Acta Oncol. 2013 Aug;52(6):1223-4 (medline /23368679)
CM - Cites: PLoS One. 2013 Oct 24;8(10):e78768 (medline /24205315)
CM - Cites: Cancer Chemother Pharmacol. 2013 Jun;71(6):1599-607 (medline
/23609479)
CM - Cites: J Cardiovasc Electrophysiol. 2006 Mar;17(3):333-6 (medline
/16643414)
CM - Cites: Physiol Rev. 2012 Jul;92 (3):1393-478 (medline /22988594)
CM - Cites: Med Oncol. 2012 Dec;29(5):3265-71 (medline /22752572)
CM - Cites: Drug Saf. 2015 Aug;38(8):693-710 (medline /26008987)
CM - Cites: J Clin Oncol. 2015 Oct 20;33(30):3488-515 (medline /26324367)
CM - Cites: J Cancer Res Clin Oncol. 2008 Jan;134(1):75-82 (medline /17636329)
CM - Cites: Card Electrophysiol Clin. 2016 Jun;8(2):481-93 (medline /27261836)
CM - Cites: Expert Opin Pharmacother. 2012 Dec;13(17 ):2533-43 (medline
/23094782)
CM - Cites: Ther Clin Risk Manag. 2008 Dec;4(6):1367-70 (medline /19337443)
CM - Cites: Clin Lymphoma Myeloma. 2008 Aug;8(4):253-5 (medline /18765315)
CM - Cites: J Electrocardiol. 2004;37 Suppl:81-90 (medline /15534815)
CM - Cites: Anticancer Drugs. 2007 Apr;18(4):493-8 (medline /17351403)
CM - Cites: J Chin Med Assoc. 2013 Aug;76(8):466-9 (medline /23769882)
CM - Cites: J Pharmacol Toxicol Methods. 2013 Sep-Oct;68(2):250-259 (medline
/23337247)
CM - Cites: Acta Oncol. 2009;48(1):156-7 (medline /18618340)
CM - Cites: Cancer Chemother Pharmacol. 2014 Jun;73(6):1109-17 (medline
/24658627)
CM - Cites: Cancer. 2010 Mar 15;116(6):1582-91 (medline /20108303)
CM - Cites: Cardiol J. 2012;19(4):434-8 (medline /22825908)
CM - Cites: Eur J Pharmacol. 2010 Mar 10;629(1-3):96-103 (medline /20006599)
CM - Cites: Clin Pharmacol Ther. 2007 May;81(5):719-28 (medline /17329992)
DOCNO- medline/29876021

416 - TOXLINE
TI - Trace elements bioavailability to winter wheat (Triticum aestivum L.)
grown subsequent to high biomass plants in a greenhouse study.
AU - Neu S
AD - a Institute of General Ecology and Environmental Protection, Technische
Universit�t Dresden , Tharandt , Germany.
AU - M�ller I
AD - b Saxon State Office for Environment, Agriculture, and Geology , Dresden,
Pillnitz , Germany.
AU - Herzig R
AD - c Phytotech Foundation and AGB , Bern , Switzerland.
AU - Dudel EG
AD - a Institute of General Ecology and Environmental Protection, Technische
Universit�t Dresden , Tharandt , Germany.
SO - Int J Phytoremediation. 2018, May 12; 20(6):574-580. [International
journal of phytoremediation]
AB - Multielement-contaminated agricultural land requires the adaptation of
agronomic practices to meet legal requirements for safe biomass
production. The incorporation of bioenergy plants with, at least, moderate
phytoextraction capacity into crop rotations with cereals can affect trace
elements (TE) phytoavailability and, simultaneously, constitute economic
revenues for farmers outside the food or forage sector. Hence, in a crop
rotation pot study sunflower (Helianthus annuus L.), modified for high
biomass and TE accumulation by chemical mutagenesis, was compared to
winter oilseed rape (Brassica napus L.) as pre-crop. On two agricultural
soils with different TE loads, the crops&acute; potential for
phytoextraction and for impacts on TE uptake by subsequent winter wheat
(Triticum aestivum L.) was studied. The results showed that rape tolerated
high-level mixed contamination with metals (Cd, Pb and Zn) and As more
than sunflower. In both soils, labile metals concentration increased and
soil acidity remained high following sunflower. Furthermore, enhanced
grain As accumulation in subsequent wheat was observed. By contrast, soil
acidity and Cd or Zn accumulation of subsequent wheat decreased following
rape. In the short term, moderate phytoextraction was superimposed by
nutrient use or rhizosphere effects of pre-crops, which should be
carefully monitored when designing crop rotations for contaminated land.
KW - Heavy metals and arsenic
KW - enhanced sunflower
KW - winter oilseed rape
LA - eng
IS - 1549-7879 (Electronic)
PT - Journal Article
TA - Int J Phytoremediation
YR - 2018
DATE- 20180424
CITO- NLM
CS - United States
FJT - International journal of phytoremediation
STAT- In-Process
DOCNO- medline/29688048

417 - TOXLINE
TI - Removal of metal(oid)s from contaminated water using iron-coated peat
sorbent.
AU - Kasiuliene A
AD - Department of Civil, Environmental and Natural Resources Engineering, Lulea
University of Technology, SE-97187, Lule�, Sweden. Electronic address:
alfreda.kasiuliene@ltu.se.
AU - Carabante I
AD - Department of Civil, Environmental and Natural Resources Engineering, Lulea
University of Technology, SE-97187, Lule�, Sweden.
AU - Bhattacharya P
AD - Department of Sustainable Development, Environmental Science and Engineering,
Royal Institute of Technology, Teknikringen 76, SE-100 44, Stockholm, Sweden.
AU - Caporale AG
AD - Department of Agricultural Sciences, University of Naples Federico II, Via
Universit�, 100-80055, Portici, Italy.
AU - Adamo P
AD - Department of Agricultural Sciences, University of Naples Federico II, Via
Universit�, 100-80055, Portici, Italy.
AU - Kumpiene J
AD - Department of Civil, Environmental and Natural Resources Engineering, Lulea
University of Technology, SE-97187, Lule�, Sweden.
SO - Chemosphere. 2018, May; 198:290-296. [Chemosphere]
AB - This study aimed at combining iron and peat to produce a sorbent suitable
for a simultaneous removal of cations and anions from a solution. Peat
powder, an industrial residue, was coated with iron by immersing peat into
iron salt solutions. The adsorption efficiency of the newly produced
sorbent towards As, Cr, Cu and Zn was tested by means of batch adsorption
experiments at a constant pH value of 5. Coating of Fe on peat
significantly increased the adsorption of As (from < 5% to 80%) and Cr
(from < 3% to 25%) in comparison to uncoated peat. Removal of cations on
coated peat slightly decreased (by 10-15%), yet remained within acceptable
range. Electron Microscopy combined with X-Ray Energy Dispersive
Spectroscopy revealed that iron coating on the peat was rather homogenous
and As and Cr were abundantly adsorbed on the surface. By contrast, Cu and
Zn displayed a sparing distribution on the surface of the iron coated
peat. These results indicate that iron-peat simultaneously target
sufficient amounts of both cations and anions and can be used for a
one-step treatment of contaminated groundwater.
KW - Arsenic
KW - Copper
KW - Iron oxide
KW - Metals
KW - Sorption
KW - Trace elements
RN - E1UOL152H7
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180529
CI - Copyright &copy; 2018 The Authors. Published by Elsevier Ltd.. All rights
reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180206
STAT- MEDLINE
DOCNO- medline/29421741

418 - TOXLINE
TI - Determination of Trace Elements in Infant Formulas Available on Polish
Market.
AU - Chajduk E
AD - Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-190, Warsaw,
Poland. e.chajduk@ichtj.waw.pl.
AU - Pyszynska M
AD - Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-190, Warsaw,
Poland.
AU - Polkowska-Motrenko H
AD - Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-190, Warsaw,
Poland.
SO - Biol Trace Elem Res. 2018, Apr 21. [Biological trace element research]
AB - The aim of this study was to assess the levels of 13 essential and toxic
elements (As, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, Se, V, Zn) in the infant
formulas, available on Polish market. Selected food samples were of animal
(cow- and goat-based milks) and plant (soy-based milk, hypoallergic
products, grain porridges) origin. Two analytical techniques, inductively
coupled plasma mass spectrometry (ICP-MS) and neutron activation analysis
(NAA), have been complementarily applied to analyze elemental content of
16 formulas dedicated for infants between 0 and 8 months. For arsenic
determinations, the radiochemical mode of NAA was also used. The daily
intake of some micronutrients in the age 0-8 months for non-breastfed
infants was estimated and compared with present safety limits. Certified
reference materials (CRMs) have been used for the validation of the
methods: Non-fat Milk Powder 1549 (National Bureau of Standards-NBS), Soya
Bean Flour INCT-SBF-4 (Institute of Nuclear Chemistry and
Technology-INCT), Rice Flour SRM 1568b (National Institute of Standards
and Technology-NIST).
KW - Estimated daily intakes for infants
KW - ICP-MS
KW - Infant formulas
KW - NAA
KW - Trace elements
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180421
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180421
STAT- Publisher
DOCNO- medline/29679351

419 - TOXLINE
TI - Influence of ore processing activity on Hg, As and Sb contamination and
fractionation in soils in a former mining site of Monte Amiata ore
district (Italy).
AU - Protano G
AD - Department of Environmental, Earth and Physical Sciences, University of
Siena, Via del Laterino 8, I-53100, Siena, Italy. Electronic address:
giuseppe.protano@unisi.it.
AU - Nannoni F
AD - Department of Environmental, Earth and Physical Sciences, University of
Siena, Via del Laterino 8, I-53100, Siena, Italy.
SO - Chemosphere. 2018, May; 199:320-330. [Chemosphere]
AB - A geochemical study was carried out at the former Abbadia San Salvatore
(ASS) mining site of the Monte Amiata ore district (Italy). Hg, As and Sb
total contents and fractionation using a sequential extraction procedure
were determined in soil and mining waste samples. Ore processing
activities provided a different contribution to Hg contamination and
concentration in soil fractions, influencing its behaviour as volatility
and availability. Soils of roasting zone showed the highest Hg
contamination levels mainly due to the deposition of Hg released as Hg0 by
furnaces during cinnabar roasting. High Hg contents were also measured in
waste from the lower part of mining dump due to the presence of cinnabar.
The fractionation pattern suggested that Hg was largely as volatile
species in both uncontaminated and contaminated soils and mining waste,
and concentrations of these Hg species increased as contamination
increased. These findings were in agreement with the fact that the ASS
mining site is characterized by high Hg concentrations in the air and the
presence of Hg0 liquid droplets in soil. Volatile Hg species were also
prevalent in uncontaminated soils likely because the Monte Amiata region
is an area characterized by anomalous fluxes of gaseous Hg from natural
and anthropogenic inputs. At the ASS mining site soils were also
contaminated by Sb, while As contents were comparable with its local
background in soil. In all soil and waste samples Sb and As were
preferentially in residual fraction.
KW - Contamination
KW - Fractionation
KW - Mercury
KW - Mining waste
KW - Sequential extraction
KW - Soil
RN - 9IT35J3UV3
RN - FXS1BY2PGL
RN - N712M78A8G
RN - ZI0T668SF1
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180608
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180209
STAT- MEDLINE
DOCNO- medline/29448200

420 - TOXLINE
TI - Can in vitro assays account for interactions between inorganic
co-contaminants observed during in vivo relative bioavailability
assessment?
AU - Ollson CJ
AD - Future Industries Institute, University of South Australia, Mawson Lakes, SA
5095, Australia; Cooperative Research Centre for Contamination Assessment and
Remediation of Environment (CRC CARE), University of Newcastle, Callaghan, NSW,
2308, Australia. Electronic address: cameron.ollson@mymail.unisa.edu.au.
AU - Smith E
AD - Future Industries Institute, University of South Australia, Mawson Lakes, SA
5095, Australia.
AU - Juhasz AL
AD - Future Industries Institute, University of South Australia, Mawson Lakes, SA
5095, Australia.
SO - Environ Pollut. 2018, Feb; 233:348-355. [Environmental pollution (Barking,
Essex : 1987)]
AB - In vitro assays act as surrogate measurements of relative
bioavailability (RBA) for inorganic contaminants. The values derived from
these assays are routinely used to refine human health risk assessments
(HHRA). Extensive in vitro research has been performed on three major
inorganic contaminants; As, Cd and Pb. However, the majority of these
studies have evaluated the contaminants individually, even in cases when
they are found as co-contaminants. Recently, in vivo studies (animal
model) have determined that when the three aforementioned contaminants are
present in the same soil matrix, they have the ability to influence each
other's individual bioavailability. Since in vitro assays are used to
inform HHRA, this study investigated whether bioaccessibility methods
including the Solubility/Bioavailability Research Consortium (SBRC) assay,
and physiologically based extraction test (PBET), have the ability to
detect interactions between As, Cd and Pb. Using a similar dosing
methodology to recently published in vivo studies, spiked aged (12
years) soil was assessed by evaluating contaminant bioaccessibility
individually, in addition to tertiary combinations. In two spiked aged
soils (grey and brown chromosols), there was no influence on contaminant
bioaccessibility when As, Cd and Pb we present as co-contaminants.
However, in a red ferrosol, the presence of As and Pb significantly
decreased (p < 0.05) the bioaccessibility of Cd when assessed
using gastric and intestinal phases of the SBRC assay and the PBET.
Conceivable, differences in key physico-chemical properties (TOC, Fe, Al,
P) between the study soils influenced contaminant interactions and
bioaccessibility outcomes. Although bioaccessibility methods may not
account for interactions between elements as demonstrated in in vivo
models, in vitro assessment provides a conservative prediction of
contaminant RBA under co-contaminant scenarios.
KW - Arsenic
KW - Bioaccessibility
KW - Cadmium
KW - Lead
KW - Spiked aged soil
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180418
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20171105
STAT- MEDLINE
DOCNO- medline/29096308

421 - TOXLINE
TI - Concentration of heavy metals in seafood (fishes, shrimp, lobster and
crabs) and human health assessment in Saint Martin Island, Bangladesh.
AU - Baki MA
AD - Faculty of Life and Earth Science, Department of Zoology, Jagannath
University, Dhaka 1100, Bangladesh. Electronic address: mabaki@gmail.com.
AU - Hossain MM
AD - Faculty of Life and Earth Science, Department of Zoology, Jagannath
University, Dhaka 1100, Bangladesh.
AU - Akter J
AD - Faculty of Life and Earth Science, Department of Zoology, Jagannath
University, Dhaka 1100, Bangladesh.
AU - Quraishi SB
AD - Analytical Chemistry Laboratory, Atomic Energy Centre Dhaka, Bangladesh
Atomic Energy Commission, Bangladesh.
AU - Haque Shojib MF
AD - Faculty of Life and Earth Science, Department of Zoology, Jagannath
University, Dhaka 1100, Bangladesh.
AU - Atique Ullah AKM
AD - Analytical Chemistry Laboratory, Atomic Energy Centre Dhaka, Bangladesh
Atomic Energy Commission, Bangladesh.
AU - Khan MF
AD - Centre for Tropical Climate Change System, Institute of Climate Change,
University Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
SO - Ecotoxicol Environ Saf. 2018, Sep 15; 159:153-163. [Ecotoxicology and
environmental safety]
AB - A contaminated aquatic environment may end up in the food chain and pose
risks to tourist health in a tourist destination. To assess the health
risk for tourists that visit St. Martine Island, which is a popular
domestic and foreign tourist destination in Bangladesh, a study is
undertaken to analyse the level of heavy metal contamination from chromium
(Cr), manganese (Mn), copper (Cu), zinc (Zn), arsenic (As), cadmium (Cd),
lead (Pb), mercury (Hg) and iron (Fe) in six of the most consumed fish (L.
fasciatus, R. kanagurta, H. nigrescens, P. cuneatus, P. annularis and S.
rubrum) and five crustacean species, which consist of a shrimp (P.
sculptilis), a lobster (P. versicolor) and three crabs (P. sanguinolentus,
T. crenata and M. victor) captured. The samples were analysed for trace
metals using atomic absorption spectrometer, and the concentrations of the
metals were interpreted using the United State Environmental Protection
Agency (USEPA) health risk model. The muscle and carapace/exoskeleton of
shrimp, lobster and crabs were analysed and contained various
concentrations of Pb, Hg, As, Cr, Cd, Fe, Cu, Zn and Mn. The hierarchy of
the heavy metal in marine fish is Fe > &#8239;Cd > &#8239;Zn
> &#8239;Pb > &#8239;Cu > &#8239;Cr > &#8239;Mn > &#8239;Hg. The
concentrations of Pb in the species R. kanagurta, H. nigresceus and S.
rubrum were above the food safety guideline by Australia, New Zealand and
other legislations in most marine fish and crustaceans. Crabs showed
higher mean heavy metal concentrations than shrimp and lobster. Acceptable
carcinogen ranges were observed in three fish species (R. kanagurata, H.
nigresceus and S. rubrum) and one crustacean species (P. sculptilis)
samples.
KW - Health risk
KW - Heavy metals
KW - Sea food
KW - St. Martin Island
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180527
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180507
STAT- In-Process
DOCNO- medline/29747150

422 - TOXLINE
TI - Fractionation and mobility of thallium in areas impacted by
mining-metallurgical activities: Identification of a water-soluble Tl(I)
fraction.
AU - Cruz-Hern�ndez Y
AD - Laboratorio de Geoqu�mica Ambiental, Instituto de Geolog�a, Universidad
Nacional Aut�noma de M�xico Ciudad Universitaria, 04510, Ciudad de M�xico, Mexico.
AU - Ruiz-Garc�a M
AD - Laboratorio de Geoqu�mica Ambiental, Instituto de Geolog�a, Universidad
Nacional Aut�noma de M�xico Ciudad Universitaria, 04510, Ciudad de M�xico, Mexico.
AU - Villalobos M
AD - Laboratorio de Geoqu�mica Ambiental, Instituto de Geolog�a, Universidad
Nacional Aut�noma de M�xico Ciudad Universitaria, 04510, Ciudad de M�xico, Mexico.
Electronic address: mar.villa@stanfordalumni.org.
AU - Romero FM
AD - Laboratorio de Geoqu�mica Ambiental, Instituto de Geolog�a, Universidad
Nacional Aut�noma de M�xico Ciudad Universitaria, 04510, Ciudad de M�xico, Mexico.
AU - Meza-Figueroa D
AD - Departamento de Geolog�a, Divisi�n de Ciencias Exactas y Naturales,
Universidad de Sonora, 83000, Hermosillo, Sonora, Mexico.
AU - Garrido F
AD - Museo Nacional de Ciencias Naturales (CSIC), C/ Jos� Guti�rrez Abascal, 2,
28026, Madrid, Spain.
AU - Hern�ndez-Alvarez E
AD - Laboratorio de ICP-MS, Instituto de Geof�sica, Universidad Nacional Aut�noma
de M�xico Ciudad Universitaria, 04510, Ciudad de M�xico, Mexico.
AU - Pi-Puig T
AD - Laboratorio de DRX, Instituto de Geolog�a, Universidad Nacional Aut�noma de
M�xico Ciudad Universitaria, 04510, Ciudad de M�xico, Mexico.
SO - Environ Pollut. 2018, Jun; 237:154-165. [Environmental pollution (Barking,
Essex : 1987)]
AB - Mining and metallurgy generate residues that may contain thallium (Tl), a
highly toxic metal, for which it is currently not feasible to determine
its geochemical speciation through X-ray absorption spectroscopy due to a
combination of very low contents and the interference of accompanying high
arsenic contents. Therefore, fractionation studies in residues and soils
are required to analyze the mobility and bioavailability of this metal,
which in turn provide information to infer its speciation. For this
purpose, in this work a modification of the BCR procedure was applied to
residues and contaminated soils from three mining zones of Mexico and two
mining zones of Spain, spanning samples with acidic to alkaline pH values.
The Tl extraction procedure consisted of the following fractions: (1)
water-extractable, (2) easily exchangeable and associated to carbonates,
associated to (3) poorly-crystalline and (4) crystalline Fe and Mn
oxyhydroxides, and (5) associated to organic matter and sulfides; and
finally a residual fraction as associated to refractory primary and other
secondary minerals. The extracted contents were analyzed by
Inductively-Coupled Plasma with Mass Spectrometry. Surprisingly,
water-soluble, in Tl(I) oxidation state, was detected in most areas,
regardless of the pH, a fact that has not been reported before in these
environments, and alerts to potential health risks not previously
identified. Most of the samples from a metallurgy area showed high levels
of Tl in non-residual fractions and a strong correlation was obtained
between extracted Mn and Tl in the third fraction, suggesting its
association to poorly crystalline manganese oxides. In the majority of
samples from purely mining environments, most of the Tl was found in the
residual fraction, most probably bound to alumino-silicate minerals. The
remaining Tl fractions were extracted mainly associated to the reducible
mineral fractions, and in one case also in the oxidizable fraction
(presumably associated to sulfides). Capsule: Soluble Tl(I) was found in
all soil samples contaminated with either mining or metallurgical wastes.
Additionally, in those affected by metallurgical wastes a very strong
Tl-Mn correlation was found.
KW - Mining residues
KW - Mn oxides
KW - Sequential extraction
KW - Thallium speciation
KW - Water-soluble
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180419
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180223
STAT- In-Process
DOCNO- medline/29482021

423 - TOXLINE
TI - Establishment of a dietary exposure assay for evaluating the toxicity of
insecticidal compounds to Apolygus lucorum (Hemiptera: Miridae).
AU - Zhao M
AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests,
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing,
100193, China.
AU - Li Y
AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests,
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing,
100193, China.
AU - Yuan X
AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests,
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing,
100193, China.
AU - Liang G
AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests,
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing,
100193, China. Electronic address: gmliang@ippcaas.cn.
AU - Wang B
AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests,
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing,
100193, China.
AU - Liu C
AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests,
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing,
100193, China.
AU - Khaing MM
AD - State Key Laboratory for Biology of Plant Diseases and Insect Pests,
Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing,
100193, China.
SO - Environ Pollut. 2018, Jun; 237:414-423. [Environmental pollution (Barking,
Essex : 1987)]
AB - With the commercialization of transgenic cotton that expresses Bt
(Bacillus thuringiensis) insecticidal proteins, mirid bugs have become key
pests in cotton and maize fields in China. Genetically engineered (GE)
crops for controlling mirids are unavailable owing to a lack of suitable
insecticidal genes. In this study, we developed and validated a dietary
exposure assay for screening insecticidal compounds and for assessing the
potential effects of insecticidal proteins produced by GE plants on
Apolygus lucorum, one of the main mirid pests of Bt cotton and Bt maize.
Diets containing potassium arsenate (PA) or the cysteine protease
inhibitor E-64 were used as positive controls for validating the efficacy
of the dietary exposure assay. The results showed that with increasing
concentrations of PA or E-64, A. lucorum larval development time was
prolonged and adult weight and fecundity were decreased, suggesting that
the dietary exposure assay was useful for detecting the toxicity of
insecticidal compounds to A. lucorum. This assay was then used to
assess the toxicity of Cry1Ab, Cry1Ac, Cry1F, Cry2Aa, and Cry2Ab proteins,
which have been transformed into several crops, against A. lucorum.
The results showed that A. lucorum did not show a negative effect by
feeding on an artificial diet containing any of the purified Cry proteins.
No significant changes in the activities of digestive, detoxifying, or
antioxidant enzymes were detected in A. lucorum that fed on a diet
containing Cry proteins, but A. lucorum fitness was reduced when the
insect fed on a diet containing E-64 or PA. These results demonstrate that
A. lucorum is not sensitive to the tested Cry proteins and that the
dietary exposure assay is useful for evaluating the toxicity of
insecticidal compounds to this species.
KW - Apolygus lucorum
KW - Cry protein
KW - E-64
KW - Environmental risk assessment
KW - Genetically engineered crop
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180419
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180315
STAT- In-Process
DOCNO- medline/29502004

424 - TOXLINE
TI - Potential health risks via consumption of six edible shellfish species
collected from Piura - Peru.
AU - Loaiza I
AD - Ghent University, Department of Biology, Marine Biology, Krijgslaan 281/S8,
B-9000 Ghent, Belgium; University of Antwerp, SPHERE - Systematic Physiological and
Ecotoxicological Research, Groenenborgerlaan 171, 2020 Antwerp, Belgium; Carrera de
Biolog�a Marina, Universidad Cient�fica del Sur. Av. Antigua Carretera Panamericana
Sur km 19 Villa El Salvador, Lima 42, Peru. Electronic address:
ivan.loaizaalamo@ugent.be.
AU - De Troch M
AD - Ghent University, Department of Biology, Marine Biology, Krijgslaan 281/S8,
B-9000 Ghent, Belgium.
AU - De Boeck G
AD - University of Antwerp, SPHERE - Systematic Physiological and Ecotoxicological
Research, Groenenborgerlaan 171, 2020 Antwerp, Belgium.
SO - Ecotoxicol Environ Saf. 2018, Sep 15; 159:249-260. [Ecotoxicology and
environmental safety]
AB - Scallops and their potential predators were collected in Sechura Bay and
in front of the Illescas Reserved Zone (north Peru), during El
Ni�o-Southern Oscillation (ENSO) 2016, and analyzed for the metals
chromium (Cr), manganese (Mn), iron (Fe), nickel (Ni), copper (Cu), zinc
(Zn), arsenic (As), cadmium (Cd) and lead (Pb). This study showed that
~20% of the molluscs exceeded the maximum residual levels (MRLs) for human
consumption in inorganic As, while ~30% of the crustaceans did. For Cd,
around 10% and 40% of the molluscs and the crustaceans were above the
MRLs, respectively. The cephalopod Octopus mimus exhibited As
concentrations, but not Cd concentrations, that exceeded the MRLs. Cr, Ni,
Cu, Zn and Pb in muscle exhibited generally concentrations below the MRLs.
Integrated risk indices were estimated to determine if there is a health
risk for consumption. Target hazard quotients (THQs) and total hazard
indices (HIs) were mostly < &#8239;1, implying no human health risk.
Provisional tolerable weekly intake (PTWI) for Cd was exceeded in Bursa
ventricosa at Illescas Reserved Zone. Target cancer risks (TRs) for
inorganic As were always higher than the threshold
(1&#8239;&times;&#8239;10-6), therefore an actual cancer risk is present.
KW - Argopecten purpuratus
KW - Health risk
KW - Piura
KW - Predator
KW - Trace metal
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180527
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180521
STAT- In-Process
DOCNO- medline/29758509

425 - TOXLINE
TI - [Progress in research of relationship between heavy metal exposure and
cardiovascular disease].
AU - Lu F
AD - National Institute of Environmental Health, Chinese Center for Disease
Control and Prevention, Beijing 100021, China.
AU - Zhao F
AD - National Institute of Environmental Health, Chinese Center for Disease
Control and Prevention, Beijing 100021, China.
AU - Cai JY
AD - National Institute of Environmental Health, Chinese Center for Disease
Control and Prevention, Beijing 100021, China.
AU - Liu L
AD - National Institute of Environmental Health, Chinese Center for Disease
Control and Prevention, Beijing 100021, China.
AU - Shi XM
AD - National Institute of Environmental Health, Chinese Center for Disease
Control and Prevention, Beijing 100021, China.
SO - Zhonghua Liu Xing Bing Xue Za Zhi. 2018, Jan 10; 39(1):102-106. [Zhonghua
liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi]
AB - Heavy metal is one of pollutants existed widely in the environment, its
relationship with cardiovascular disease has attracted more and more
attention. In this review, the concentrations of heavy metals, including
lead, cadium and asenic, in the body from several national surveillance
networks and the epidemiological studies on the effects of the exposure of
three heavy metals on cardiovascular system were summarized. It is
suggested to strengthen nationwide surveillance for body concentrations of
heavy metals in general population in order to provide baseline data for
quantitative evaluation of the risk of heavy metal exposure on
cardiovascular disease.
AB -
&#37325;&#37329;&#23646;&#26159;&#37325;&#35201;&#29615;&#22659;&#27745;&#26579;&#2
9289;&#20043;&#19968;&#65292;&#20854;&#23545;&#24515;&#34880;&#31649;&#31995;&#3247
9;&#30340;&#25439;&#23475;&#24050;&#22791;&#21463;&#22269;&#20869;&#22806;&#23398;&
#32773;&#30340;&#20851;&#27880;&#12290;&#26412;&#25991;&#22522;&#20110;&#37325;&#37
329;&#23646;&#20154;&#20307;&#36127;&#33655;&#27700;&#24179;&#12289;&#37325;&#37329
;&#23646;&#26292;&#38706;&#23545;&#24515;&#34880;&#31649;&#31995;&#32479;&#21361;&#
23475;&#30340;&#30456;&#20851;&#30740;&#31350;&#25104;&#26524;&#65292;&#32508;&#368
48;&#38085;&#12289;&#38217;&#12289;&#30775;3&#31181;&#24120;&#35265;&#37325;&#37329
;&#23646;&#26292;&#38706;&#19982;&#24515;&#34880;&#31649;&#30142;&#30149;&#20851;&#
31995;&#30340;&#27969;&#34892;&#30149;&#23398;&#30740;&#31350;&#36827;&#23637;&#652
92;&#24182;&#25552;&#20986;&#24212;&#21152;&#24378;&#20840;&#22269;&#33539;&#22260;
&#19968;&#33324;&#20154;&#32676;&#37325;&#37329;&#23646;&#36127;&#33655;&#27700;&#2
4179;&#30340;&#30417;&#27979;&#65292;&#20197;&#21033;&#20110;&#23450;&#37327;&#3578
0;&#20272;&#37325;&#37329;&#23646;&#26292;&#38706;&#25152;&#33268;&#30340;&#24515;&
#34880;&#31649;&#30142;&#30149;&#39118;&#38505;&#12290;.
KW - Arsenic
KW - Cadmium
KW - Cardiovascular disease
KW - Heavy metal
KW - Lead
RN - 00BH33GNGH
RN - 2P299V784P
LA - chi
IS - 0254-6450 (Print)
PT - Journal Article
TA - Zhonghua Liu Xing Bing Xue Za Zhi
YR - 2018
DATE- 20180417
CITO- NLM
CS - China
CSET- IM
FJT - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
STAT- MEDLINE
DOCNO- medline/29374907

426 - TOXLINE
TI - Heavy metal contamination, microbiological spoilage and biogenic amine
content in sushi available on the Polish market.
AU - Kulawik P
AD - Department of Animal Product Technology, Faculty of Food Technology,
University of Agriculture, Krakow, Poland.
AU - Dordevic D
AD - Department of Plant Origin Foodstuffs Hygiene and Technology, Faculty of
Veterinary Hygiene and technology, University of Veterinary and Pharmacutical
Sciences Brno, Czech Republic.
AU - Gambu&#347; F
AD - Department of Agricultural and Environmental Chemistry, Faculty of
Agriculture and Economies, University of Agriculture, Krakow, Poland.
AU - Szczurowska K
AD - Department of Agricultural and Environmental Chemistry, Faculty of
Agriculture and Economies, University of Agriculture, Krakow, Poland.
AU - Zaj&#261;c M
AD - Department of Animal Product Technology, Faculty of Food Technology,
University of Agriculture, Krakow, Poland.
SO - J Sci Food Agric. 2018, May; 98(7):2809-2815. [Journal of the science of
food and agriculture]
AB - BACKGROUND: The present study determined the heavy metal contamination
(mercury, cadmium, lead, arsenic and nickel) of nori, restaurant-served
sushi and ready-to-eat sushi meals available via retail chains. Moreover,
both microbiological load and biogenic amine content in ready-to-eat sushi
meals were analysed.
AB - RESULTS: All of the nori samples contained high levels of Cd
(2.122&thinsp;mg kg-1 ), Ni (0.715&thinsp;mg kg-1 ), As (34.56&thinsp;mg
kg-1 ) and Pb (0.659&thinsp;mg kg-1 ). The studied sushi samples contained
high levels of Ni and Pb, reaching 0.194 and 0.142&thinsp;mg kg-1 wet
weight, respectively, being potentially hazardous to women during
pregnancy and lactation and small children. None of the studied samples
contained high levels of Hg. Overall, 37% of ready-to-eat sushi meals
exceeded a microbiological load of 106 &thinsp;cfu g-1 . However, biogenic
amine content in all of the samples was low, with a highest histamine
content of 2.05&thinsp;mg kg-1 .
AB - CONCLUSION: Sushi is not the source of high levels of biogenic amines even
with high microbiological loads. Nevertheless, the high microbiological
loads at the end of the shelf-life indicate that some processors might
have problems with the distribution chain or implement a poor hygienic
regime. Moreover as a result of possible risk associated with heavy metal
contamination, the present study highlights the need to establish new
regulations regarding the contamination of nori and sushi. &copy; 2017
Society of Chemical Industry.
KW - biogenic amines
KW - heavy metals
KW - nori
KW - sushi
KW - total viable count
LA - eng
IS - 1097-0010 (Electronic)
PT - Journal Article
TA - J Sci Food Agric
YR - 2018
DATE- 20180416
CI - &copy; 2017 Society of Chemical Industry.
CITO- NLM
CS - England
CSET- IM
FJT - Journal of the science of food and agriculture
EDAT- 20171214
STAT- MEDLINE
DOCNO- medline/29134651

427 - TOXLINE
TI - Assessment of blood levels of heavy metals including lead and manganese in
healthy children living in the Katanga settlement of Kampala, Uganda.
AU - Cusick SE
AD - Department of Pediatrics, University of Minnesota, 717 Delaware Street SE,
Minneapolis, MN, 55414, USA. scusick@umn.edu.
AU - Jaramillo EG
AD - Icahn School of Medicine at Mount Sinai, 1428 Madison Avenue, New York, NY,
10029, USA.
AU - Moody EC
AD - Icahn School of Medicine at Mount Sinai, 1428 Madison Avenue, New York, NY,
10029, USA.
AU - Ssemata AS
AD - Department of Psychology, Makerere University, Kampala, Uganda.
AU - Bitwayi D
AD - Global Health Uganda, Kampala, Uganda.
AU - Lund TC
AD - Department of Pediatrics, University of Minnesota, 717 Delaware Street SE,
Minneapolis, MN, 55414, USA.
AU - Mupere E
AD - Department of Paediatrics and Child Health, Makerere University, Kampala,
Uganda.
SO - BMC Public Health. 2018, Jun 08; 18(1):717. [BMC public health]
AB - BACKGROUND: Exposure to environmental heavy metals is common among African
children. Although many of these metals are known neurotoxicants, to date,
monitoring of this exposure is limited, even in countries such as Uganda
that are undergoing rapid industrialization. An assessment of the burden
and potential causes of metal exposure is a critical first step in gauging
the public health burden of metal exposure and in guiding its elimination.
AB - METHODS: In May 2016, we enrolled 100 children between the ages of 6 and
59 months living in the Katanga urban settlement of Kampala, Uganda.
We measured whole blood concentrations of antimony, arsenic, barium,
cadmium, cesium, chromium, cobalt, copper, lead, manganese, nickel,
selenium, and zinc. Applying reference cutoffs, we identified metals whose
prevalence of elevated blood concentrations was > &thinsp;10%. We also
administered an environmental questionnaire to each child's caregiver to
assess potential exposures, including source of drinking water, cooking
location and fuel, materials used for roof, walls, and floor, and
proximity to potential pollution sources such as main roads, garbage
landfills, and fuel stations. We compared log-transformed blood metal
concentrations by exposure category, using t-test for dichotomous
comparisons and ANOVA for comparisons of three categories, using Tukeys
test to adjust for multiple comparisons.
AB - RESULTS: The prevalence of high blood levels was elevated for six of the
metals: antimony (99%), copper (12%), cadmium (17%), cobalt (19.2%), lead
(97%), and manganese (36.4%). Higher blood manganese was significantly
associated with having cement walls (p&thinsp;=&thinsp;0.04) or floors
(p&thinsp;=&thinsp;0.04). Cadmium was greater among children who attended
school ( < &thinsp;0.01), and cobalt was higher among children who lived
near a garbage landfill (p&thinsp;=&thinsp;0.01).
AB - CONCLUSIONS: Heavy metal exposure is prevalent in the Katanga settlement
and may limit neurodevelopment of children living there. Future studies
are needed to definitively identify the sources of exposure and to correct
potential nutritional deficiencies that may worsen metal absorption.
KW - Africa
KW - Environment
KW - Lead
KW - Manganese
KW - Metals
LA - eng
IS - 1471-2458 (Electronic)
PT - Journal Article
TA - BMC Public Health
YR - 2018
DATE- 20180609
CITO- NLM
CS - England
FJT - BMC public health
EDAT- 20180608
STAT- In-Data-Review
DOCNO- medline/29884149

428 - TOXLINE
TI - Assisted phytostabilization of a multicontaminated mine technosol using
biochar amendment: Early stage evaluation of biochar feedstock and
particle size effects on As and Pb accumulation of two Salicaceae species
(Salix viminalis and Populus euramericana).
AU - Lebrun M
AD - University of Orleans, INRA USC1328, LBLGC EA 1207, rue de Chartres, BP 6759,
45067, Orl�ans Cedex 2, France; Universit� degli Studi del Molise, Dipartimento di
Bioscienze e Territorio, 86090, Pesche, Italy.
AU - Miard F
AD - University of Orleans, INRA USC1328, LBLGC EA 1207, rue de Chartres, BP 6759,
45067, Orl�ans Cedex 2, France.
AU - Nandillon R
AD - University of Orleans, INRA USC1328, LBLGC EA 1207, rue de Chartres, BP 6759,
45067, Orl�ans Cedex 2, France.
AU - L�ger JC
AD - La Carbonerie, Crissey, France.
AU - Hattab-Hambli N
AD - University of Orleans, INRA USC1328, LBLGC EA 1207, rue de Chartres, BP 6759,
45067, Orl�ans Cedex 2, France.
AU - Scippa GS
AD - Universit� degli Studi del Molise, Dipartimento di Bioscienze e Territorio,
86090, Pesche, Italy.
AU - Bourgerie S
AD - University of Orleans, INRA USC1328, LBLGC EA 1207, rue de Chartres, BP 6759,
45067, Orl�ans Cedex 2, France.
AU - Morabito D
AD - University of Orleans, INRA USC1328, LBLGC EA 1207, rue de Chartres, BP 6759,
45067, Orl�ans Cedex 2, France. Electronic address: domenico.morabito@univ-
orleans.fr.
SO - Chemosphere. 2018, Mar; 194:316-326. [Chemosphere]
AB - Soil contamination by metal(loid)s is one of the most important
environmental problem. It leads to loss of environment biodiversity and
soil functions and can have harmful effects on human health. Therefore,
contaminated soils could be remediated, using phytoremediation. Indeed,
plant growth will improve soil conditions while accumulating metal(loid)s
and modifying their mobility. However, due to the poor fertility and high
metal(loid)s levels of these soils, amendments, like biochar, has to be
applied. This study was performed on a former mine technosol contaminated
by As and Pb and aimed to study (i) the effect of biochar on soil
physico-chemical properties and plant phytostabilization potential (ii)
biochar feedstock and particle size effects. In this goal, a mesocosm
experiment was set up using four different biochars, obtained from two
feedstocks (lightwood and pinewood) and harboring two particle sizes (inf.
0.1 mm and 0.2-0.4 mm) and two Salicaceae species. Soil and soil
pore water physico-chemical properties as well as plant growth and
metal(loid)s distribution were assessed. The results showed that biochar
was efficient in improving soil physico-chemical properties and reducing
Pb soil pore water concentrations. This amelioration allowed plant growth
and increased dry weight production of both species. Regarding
metal(loid)s distribution, willow and poplar showed an As and Pb
accumulation in roots and low translocation towards edible parts, i.e
stems and leaves, which shows a phytostabilization potential. Finally, the
2 biochar parameters, feedstock and particle size, only affected soil and
soil pore water physico-chemical properties while having no effect on
plant growth.
KW - Assisted phytostabilization
KW - Biochar
KW - Feedstock
KW - Particle size
KW - Salicaceae
RN - 16291-96-6
RN - 2P299V784P
RN - N712M78A8G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180416
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171128
STAT- MEDLINE
DOCNO- medline/29220748

429 - TOXLINE
TI - A Fluorescence-Based Sensor Assay that Monitors General Protein
Aggregation in Human Cells.
AU - Pereira M
AD - iBiMED - Institute of Biomedicine Department of Medical Sciences University
of Aveiro, 3810-193 Aveiro, Portugal.
AU - Tom� D
AD - iBiMED - Institute of Biomedicine Department of Medical Sciences University
of Aveiro, 3810-193 Aveiro, Portugal.
AU - Domingues AS
AD - iBiMED - Institute of Biomedicine Department of Medical Sciences University
of Aveiro, 3810-193 Aveiro, Portugal.
AU - Varanda AS
AD - iBiMED - Institute of Biomedicine Department of Medical Sciences University
of Aveiro, 3810-193 Aveiro, Portugal.
AU - Paulo C
AD - iBiMED - Institute of Biomedicine Department of Medical Sciences University
of Aveiro, 3810-193 Aveiro, Portugal.
AU - Santos MAS
AD - iBiMED - Institute of Biomedicine Department of Medical Sciences University
of Aveiro, 3810-193 Aveiro, Portugal.
AU - Soares AR
AD - iBiMED - Institute of Biomedicine Department of Medical Sciences University
of Aveiro, 3810-193 Aveiro, Portugal.
SO - Biotechnol J. 2018, Apr; 13(4):e1700676. [Biotechnology journal]
AB - Protein conformational disorders are characterized by disruption of
protein folding and toxic accumulation of protein aggregates. Here we
describe a sensitive and simple method to follow and monitor general
protein aggregation in human cells. Heat shock protein 27 (HSP27) is an
oligomeric small heat shock protein that binds and keeps unfolded proteins
in a folding competent state. This high specificity of HSP27 for
aggregated proteins can be explored to monitor aggregation in living cells
by fusing it to a fluorescent protein as Green Fluorescent Protein (GFP).
We have constructed a HeLa stable cell line expressing a HSP27:GFP
chimeric reporter protein and after validation, this stable cell line is
exposed to different agents that interfere with proteostasis, namely
Arsenite, MG132, and A&beta;-peptide. Exposure to proteome destabilizers
lead to re-localization of HSP27:GFP fluorescence to foci, confirming that
our reporter system is functional and can be used to detect and follow
protein aggregation in living cells. This reporter is a valuable tool to
setup wide-genetic screens to identify genes and pathways involved in
protein misfolding and aggregation.
KW - GFP
KW - HSP27
KW - fluorescence sensor assay
KW - human cells
KW - protein aggregation
LA - eng
IS - 1860-7314 (Electronic)
PT - Journal Article
TA - Biotechnol J
YR - 2018
DATE- 20180416
CI - &copy; 2018 The Authors. Biotechnology Journal Published by
Wiley-VCHVerlag GmbH &amp; Co. KGaA, Weinheim.
CITO- NLM
CS - Germany
FJT - Biotechnology journal
EDAT- 20180305
STAT- In-Process
DOCNO- medline/29345424

430 - TOXLINE
TI - Clinical outcomes, histopathological patterns, and chemical analysis of
Ayurveda and herbal medicine associated with severe liver injury-A
single-center experience from southern India.
AU - Philips CA
AD - Department of Hepatology and Liver Transplant Medicine, PVS Memorial
Hospital, Kochi, 682 025, India. abbyphilips@gmail.com.
AU - Paramaguru R
AD - Department of Pathology, PVS Memorial Hospital, Kochi, 682 025, India.
AU - Joy AK
AD - Sophisticated Test and Instrumentation Centre, Cochin University of Science
and Technology, Kochi, 682 022, India.
AU - Antony KL
AD - Envirodesigns Eco Labs, Kochi, 682 025, India.
AU - Augustine P
AD - Department of Gastroenterology, PVS Memorial Hospital, Kochi, 682 025, India.
SO - Indian J Gastroenterol. 2018, 01; 37(1):9-17. [Indian journal of
gastroenterology : official journal of the Indian Society of
Gastroenterology]
AB - INTRODUCTION: Ayurvedic and herbal medicines (AHM) are known to cause
varying degrees of drug-induced liver injury (DILI). Clinical,
biochemical, histological spectrum and outcomes of AHM linked to severe
DILI are not well studied.
AB - METHODS: Out of 1440 liver disease patients, 94 were found to have a
severe liver injury and associated AHM intake. Thirty-three patients were
suspected to have AHM-DILI on Roussel Uclaf Causality Assessment Scoring
Method. Forty-seven and 30 of retrieved AHM samples were analyzed for
heavy metals and hepatotoxic volatile organic compounds (hVOCs),
respectively. Eleven patients ingested AHM from unregistered traditional
healers (UTH). Clinicopathological outcomes were analyzed in 27 patients
(who underwent liver biopsy) and outcomes with respect to chemical
analyses were studied in 33 patients.
AB - RESULTS: Males predominated (70.4%) with mean age 46.9&plusmn;15.8 years.
Mean follow up was 119.2&plusmn;81.4 days. The median duration of drug
intake was 28 days (10 - 84). Five patients died (18.5%). Hepatic
encephalopathy, hypoalbuminemia, and hepatic necrosis were significantly
associated with mortality (p&thinsp; < &thinsp;0.005). Arsenic and
mercury ingestion was significantly associated with death
(p&thinsp; < &thinsp;0.005). hVOCs were detected in more than 70% of
samples. AHM intake from UTH was associated with higher mortality.
AB - CONCLUSION: Adequate regulation and scrutiny regarding AHM use among the
general population is an unmet need. Early liver biopsy after clinical
identification of at-risk patients can expedite definitive treatment with
a liver transplant.
KW - *Ayurveda
KW - *Drug-induced liver injury
KW - *Fibrosis
KW - *Heavy metals
KW - *Hepatotoxicity
KW - *Herbal medicines
KW - *Histopathology
KW - *Liver biopsy
KW - *Liver injury
KW - *Liver necrosis
KW - *Volatile organic compounds
LA - eng
IS - 0975-0711 (Electronic)
PT - Journal Article
TA - Indian J Gastroenterol
YR - 2018
DATE- 20180416
CITO- NLM
CS - India
FJT - Indian journal of gastroenterology : official journal of the Indian
Society of Gastroenterology
EDAT- 20180224
STAT- In-Process
CM - Comment in: Indian J Gastroenterol. 2018 Jan;37(1):5-7 (medline /29423815)
CM - Cites: Dig Dis Sci. 2011 Apr;56(4):958-76 (medline /21327704)
CM - Cites: Biomed Res Int. 2014;2014:640754 (medline /25184144)
CM - Cites: Toxicol Pathol. 2013 Feb;41(2):343-60 (medline /23262638)
CM - Cites: Hepatology. 2014 Feb;59(2):661-70 (medline /24037963)
CM - Cites: Int J Mol Sci. 2017 Sep 12;18(9):null (medline /28895915)
CM - Cites: Clin Pharmacol Ther. 2011 Jun;89(6):806-15 (medline /21544079)
CM - Cites: Springerplus. 2015 Dec 22;4:802 (medline /26702391)
CM - Cites: Aliment Pharmacol Ther. 2013 Jan;37(1):3-17 (medline /23121117)
CM - Cites: Semin Liver Dis. 2009 Nov;29(4):364-72 (medline /19826970)
CM - Cites: Gastroenterol Hepatol. 2006 Jun-Jul;29(6):334-7 (medline /16790181)
CM - Cites: JAMA. 2008 Aug 27;300(8):915-23 (medline /18728265)
CM - Cites: Environ Res. 1999 Oct;81(3):206-14 (medline /10585016)
CM - Cites: Gastroenterology. 2015 Jun;148(7):1340-52.e7 (medline /25754159)
CM - Cites: Am J Gastroenterol. 2010 Nov;105(11):2396-404 (medline /20648003)
CM - Cites: Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4 (medline
/18955056)
CM - Cites: Hepatology. 2014 Oct;60(4):1399-408 (medline /25043597)
CM - Cites: Hepatology. 2010 Jun;51(6):2040-8 (medline /20512992)
CM - Cites: Liver. 1999 Aug;19(4):299-304 (medline /10459628)
CM - Cites: Am J Med. 2004 Apr 1;116(7):478-85 (medline /15047038)
CM - Cites: Clin Liver Dis. 2017 Feb;21(1):135-149 (medline /27842768)
CM - Cites: Clin Liver Dis. 2007 Aug;11(3):577-96, vii (medline /17723921)
CM - Cites: Aliment Pharmacol Ther. 2007 Jun 15;25(12 ):1411-21 (medline
/17539980)
CM - Cites: World J Gastroenterol. 2012 Jun 14;18(22):2756-66 (medline
/22719183)
CM - Cites: Clin Gastroenterol Hepatol. 2010 May;8(5):463-70 (medline
/20170750)
CM - Cites: J Clin Epidemiol. 1993 Nov;46(11):1323-30 (medline /8229110)
DOCNO- medline/29476406

431 - TOXLINE
TI - Distribution, relationship, and risk assessment of toxic heavy metals in
walnuts and growth soil.
AU - Han Y
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China.
AU - Ni Z
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China.
AU - Li S
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China.
AU - Qu M
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China.
AU - Tang F
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China.
AU - Mo R
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China.
AU - Ye C
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China.
AU - Liu Y
AD - Research Institute of Subtropical Forestry, Chinese Academy of Forestry,
Fuyang, 311400, China. liuyh@caf.ac.cn.
SO - Environ Sci Pollut Res Int. 2018, Apr 14. [Environmental science and
pollution research international]
AB - Walnut is one of the most popular nuts worldwide and contains various
mineral nutrients. Little is known, however, about the relationship
between toxic heavy metals in walnuts and growth soil. In this study, we
investigated the distribution, relationship, and risk assessment of five
toxic heavy metals-lead (Pb), arsenic (As), chromium (Cr), cadmium (Cd),
and mercury (Hg)-in walnuts and growth soil in the main production areas
of China. The results showed that the main heavy metal pollution in walnut
and soil was Pb and Cd. Regionally, positive relationships existed between
heavy metals and the pH and organic matter of soil. In addition, we
observed a notable uptake effect between walnut and growth soil. In this
study, we found a significant correlation (r =&thinsp;0.786,
P < &thinsp;0.05) between the bioconcentration factors and the
longitude of the sampling areas. The risks (total hazard quotients) of
five heavy metals toward children and adults by dietary walnut consumption
were 46.8 and 56.2%, respectively. The ability to identify toxic heavy
metal pollution in walnuts and growth soil could be helpful to screen
suitable planting sites to prevent and control heavy metal pollution and
improve the quality and safety of walnut.
KW - Health assessment
KW - Heavy metal
KW - Relationship
KW - Soil
KW - Walnut
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180415
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180414
STAT- Publisher
DOCNO- medline/29656354

432 - TOXLINE
TI - Uptake and accumulation of potentially toxic elements in colonized plant
species around the world's largest antimony mine area, China.
AU - Long J
AD - Hunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake
Area, College of Bioscience and Biotechnology, Hunan Agricultural University,
Changsha, 410128, Hunan, People's Republic of China.
AU - Tan D
AD - College of Resources and Environment, Hunan Agricultural University,
Changsha, 410128, Hunan, People's Republic of China.
AU - Deng S
AD - College of Resources and Environment, Hunan Agricultural University,
Changsha, 410128, Hunan, People's Republic of China.
AU - Lei M
AD - Hunan Provincial Key Laboratory of Rural Ecosystem Health in Dongting Lake
Area, College of Bioscience and Biotechnology, Hunan Agricultural University,
Changsha, 410128, Hunan, People's Republic of China. leiming8166@yahoo.com.
SO - Environ Geochem Health. 2018, Apr 11. [Environmental geochemistry and
health]
AB - To provide information on reclamation of multi-heavy metal polluted soils
with conception of phytostabilization, a field survey on the uptake and
accumulation of potentially toxic elements such as antimony (Sb), arsenic
(As), lead (Pb), cadmium (Cd), copper (Cu), and zinc (Zn) in colonized
plant species around the world's largest antimony mine area, China, was
conducted. Samples including leaves and shoots (including roots and stems)
of colonized plants as well as rhizospheric soils were collected from
eight sampling zones in the studied area. The results showed that the
contents of Cu, Zn, and Pb in rhizospheric soils below plants were
comparable to the corresponding background values of Hunan province,
otherwise Sb, Cd, and As contents were extremely high (17-106, 17-87, and
3-7 times of the corresponding background values). The highest
concentration of Sb was found in Aster subulatus (410 mg kg-1);
Cd, As, and Zn were in Herba bidentis bipinnatae (10.9, 264, and
265 mg kg-1, respectively); and Cu was in Artemisia
lavandulaefolia (27.1 mg kg-1). It also exhibited that all the
contents of As in leaves were several times of those in shoots of plants,
Cd and other heavy metals showed in a similar pattern in several studied
species, implying that the uptake route of these heavy metals via foliar
might contribute to the accumulation. With high bioconcentration factors
of heavy metals (more than 1, except for Zn), together with the growth
abundance, Herba bidentis bipinnatae was considered as the most suitable
colonized species for phytostabilization of the multi-heavy metal
pollution in soils on this antimony mine area.
KW - Bioconcentration
KW - Biodistribution
KW - Heavy metal tolerance
KW - Multi-heavy metal pollution
KW - Phytostabilization
KW - Potentially toxic elements
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180412
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20180411
STAT- Publisher
DOCNO- medline/29644506

433 - TOXLINE
TI - Arsenic and Diabetes: Assessing Risk at Low-to-Moderate Exposures.
AU - Seltenrich N
SO - Environ Health Perspect. 2018, Apr 09; 126(4):044002. [Environmental
health perspectives]
LA - eng
IS - 1552-9924 (Electronic)
PT - Journal Article
TA - Environ Health Perspect
YR - 2018
DATE- 20180410
CITO- NLM
CS - United States
FJT - Environmental health perspectives
EDAT- 20180409
STAT- In-Data-Review
DOCNO- medline/29634183

434 - TOXLINE
TI - Spatial clustering of metal and metalloid mixtures in unregulated water
sources on the Navajo Nation - Arizona, New Mexico, and Utah, USA.
AU - Hoover JH
AD - Community Environmental Health Program, College Of Pharmacy, University of
New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA. Electronic
address: johoover@salud.unm.edu.
AU - Coker E
AD - Center for Environmental Research and Children's Health, School of Public
Health, University of California Berkeley, USA.
AU - Barney Y
AD - Navajo Nation Environmental Protection Agency - Public Water Systems
Supervisory Program, PO Box 339, Window Rock, AZ 86515, USA.
AU - Shuey C
AD - Southwest Research and Information Center, 105 Stanford Drive SE,
Albuquerque, NM 87106, USA.
AU - Lewis J
AD - Community Environmental Health Program, College Of Pharmacy, University of
New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA.
SO - Sci Total Environ. 2018, Aug 15; 633:1667-1678. [The Science of the total
environment]
AB - Contaminant mixtures are identified regularly in public and private
drinking water supplies throughout the United States; however, the complex
and often correlated nature of mixtures makes identification of relevant
combinations challenging. This study employed a Bayesian clustering method
to identify subgroups of water sources with similar metal and metalloid
profiles. Additionally, a spatial scan statistic assessed spatial
clustering of these subgroups and a human health metric was applied to
investigate potential for human toxicity. These methods were applied to a
dataset comprised of metal and metalloid measurements from unregulated
water sources located on the Navajo Nation, in the southwest United
States. Results indicated distinct subgroups of water sources with similar
contaminant profiles and that some of these subgroups were spatially
clustered. Several profiles had metal and metalloid concentrations that
may have potential for human toxicity including arsenic, uranium, lead,
manganese, and selenium. This approach may be useful for identifying
mixtures in water sources, spatially evaluating the clusters, and help
inform toxicological research investigating mixtures.
KW - Metal and metalloid mixtures
KW - Spatial clustering
KW - Unregulated water sources
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 The Authors. Published by Elsevier B.V. All rights
reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180415
STAT- PubMed-not-MEDLINE
DOCNO- medline/29669690

435 - TOXLINE
TI - Bioaccumulation of cadmium by Enterobacter sp. and enhancement of rice
seedling growth under cadmium stress.
AU - Mitra S
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan 713104, West Bengal, India.
AU - Pramanik K
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan 713104, West Bengal, India.
AU - Sarkar A
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan 713104, West Bengal, India; Department of Botany,
Government General Degree College, Singur, Hooghly 712409, West Bengal, India.
AU - Ghosh PK
AD - Department of Marine Science, Calcutta University, Ballygunge Science
College, 35 B.C Road, Kolkata 700019, West Bengal, India.
AU - Soren T
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan 713104, West Bengal, India.
AU - Maiti TK
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan 713104, West Bengal, India. Electronic address:
tkmbu@yahoo.co.in.
SO - Ecotoxicol Environ Saf. 2018, Jul 30; 156:183-196. [Ecotoxicology and
environmental safety]
AB - Bacteria-mediated plant growth promotion and bioremediation of heavy metal
containing soil is a widely accepted eco-friendly method. The present
study is aimed to screen out cadmium resistant bacterial strain from metal
contaminated rice rhizosphere and evaluate its effects on the growth of
rice seedlings under cadmium stress. Among four different isolates
(designated as S1, S2, S3 and S5), the S2 isolate was screened on the
basis of different PGP traits and multi heavy metal resistance (minimum
inhibitory concentration for cadmium, lead and arsenic were 3500, 2500 and
1050&#8239;&micro;g/ml respectively). The selected S2 strain has ability
to produce ACC deaminase (236.11&#8239;ng &alpha;-keto-butyrate/mg
protein/h), IAA (726&#8239;&micro;g/ml), solubilize phosphate
(73.56&#8239;ppm) and fix nitrogen (4.4&#8239;&micro;g of nitrogen
fixed/h/mg protein). The selected strain was identified as Enterobacter
sp. on the basis of phenotypic characterization, MALDI-TOF MS analysis of
ribosomal proteins, FAME analysis and 16&#8239;S rDNA sequence homology.
The high cadmium removal efficiency ( > &#8239;95%) of this strain from
the growth medium was measured by Atomic Absorption Spectrophotometer and
it was due to intracellular cadmium accumulation evidenced by
SEM-EDX-TEM-EDX study. SEM analysis also revealed no distortion of surface
morphology of this strain even grown in the presence of high cadmium
concentration (3000&#8239;&micro;g/ml). Inoculation of this strain with
rice seedlings significantly enhanced various morphological, biochemical
characters of seedling growth compared with un-inoculated seedlings under
Cd stress. The strain also exhibited alleviation of cadmium-induced
oxidative stress, reduction of stress ethylene and decreased the
accumulation of cadmium in seedlings as well that conferred cadmium
tolerance to the plant. Thus the S2 strain could be considered as a potent
heavy metal resistant PGPR applicable in heavy metal contaminated
agricultural soil for bioremediation and plant growth promotion as well.
AB - MAIN FINDING: A cadmium resistant plant growth promoting Enterobacter sp.
was isolated that accumulated cadmium evidenced by SEM-TEM-EDX study. It
reduced Cd uptake and enhanced growth in rice seedlings.
KW - Bioaccumulation
KW - Bioremediation
KW - Cd resistant
KW - Enterobacter
KW - PGPR
KW - Stress Ethylene
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180407
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180320
STAT- In-Process
DOCNO- medline/29550436

436 - TOXLINE
TI - Characterization of Cd-resistant Klebsiella michiganensis MCC3089 and its
potential for rice seedling growth promotion under Cd stress.
AU - Mitra S
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan, 713104, West Bengal, India.
AU - Pramanik K
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan, 713104, West Bengal, India.
AU - Ghosh PK
AD - Department of Marine Science, Calcutta University, Ballygunge Science
College, 35 B.C Road, Kolkata, 700019, West Bengal, India.
AU - Soren T
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan, 713104, West Bengal, India.
AU - Sarkar A
AD - Department of Botany, Government General Degree College, Singur, Hooghly,
712409, West Bengal, India.
AU - Dey RS
AD - Institute of Nano Science and Technology, Mohali, Habitat Centre Sector 64,
Phase-10, S.A.S. Nagar, Mohali, 160062, Punjab, India.
AU - Pandey S
AD - Department of Botany, Banwarilal Bhalotia College, Asansol, West Bengal,
India.
AU - Maiti TK
AD - Microbiology Laboratory, UGC Centre for Advanced Study, Department of Botany,
Burdwan University, Burdwan, 713104, West Bengal, India. Electronic address:
tkmbu@yahoo.co.in.
SO - Microbiol Res. 2018, May; 210:12-25. [Microbiological research]
AB - Application of heavy metal resistant plant growth promoting rhizobacteria
has an important role as they help to evade metal-induced toxicity in
plants on one hand and enhance plant growth on the other. The present
study is therefore focused on the characterization of a cadmium resistant
bacterial strain isolated from heavy metal contaminated rhizospheric soil
designated as S8. This S8 strain was selected in terms of cadmium
resistance and plant growth promoting traits. Moreover, it also showed
resistance to lead and arsenic to a considerable extent. The selected
strain S8 was identified as Klebsiella michiganensis by modern approaches
of bacterial taxonomy. The plant growth promoting traits exhibited by the
strain include 1-aminocyclopropane-1-carboxylic acid deaminase activity
(58.33&#8239;ng &alpha;-keto butyrate/mg protein/h), Indole-3-acetic acid
production (671&#8239;&mu;g/ml), phosphate solubilization
(71.98&#8239;ppm), nitrogen fixation (3.72&#8239;&mu;g of nitrogen
fixed/h/mg protein) etc. Besides, the strain also exhibited high cadmium
removal efficiency (73-97%) from the medium and intracellular accumulation
as well. Its efficiency to alleviate cadmium-induced toxicity was
determined against a rice cultivar in terms of morphological and
biochemical changes. Enhanced growth and reduced oxidative stress were
detected in presence of the bacterium. On the basis of these results, it
can be concluded that K. michiganensis strain S8 is cadmium accumulating
plant growth promoting rhizobacterium that can be applied in cadmium
contaminated agricultural soil to achieve better productivity of rice.
KW - ACC deaminase
KW - Bioremediation
KW - Cadmium resistant bacteria
KW - Ethylene
KW - Klebsiella sp.
KW - PGPR
LA - eng
IS - 1618-0623 (Electronic)
PT - Journal Article
TA - Microbiol Res
YR - 2018
DATE- 20180407
CI - Copyright &copy; 2018 Elsevier GmbH. All rights reserved.
CITO- NLM
CS - Germany
FJT - Microbiological research
EDAT- 20180308
STAT- In-Process
DOCNO- medline/29625654

437 - TOXLINE
TI - Analysis and Risk Assessment of Seven Toxic Element Residues in Raw Bovine
Milk in China.
AU - Qu XY
AD - Ministry of Agriculture - Laboratory of Quality and Safety Risk Assessment
for Dairy Products (Beijing), No. 2, Yuan Ming Yuan West Road, Haidian District,
Beijing, 100193, People's Republic of China.
AU - Zheng N
AD - Ministry of Agriculture - Laboratory of Quality and Safety Risk Assessment
for Dairy Products (Beijing), No. 2, Yuan Ming Yuan West Road, Haidian District,
Beijing, 100193, People's Republic of China.
AU - Zhou XW
AD - Ministry of Agriculture - Laboratory of Quality and Safety Risk Assessment
for Dairy Products (Beijing), No. 2, Yuan Ming Yuan West Road, Haidian District,
Beijing, 100193, People's Republic of China.
AU - Li SL
AD - Ministry of Agriculture - Laboratory of Quality and Safety Risk Assessment
for Dairy Products (Beijing), No. 2, Yuan Ming Yuan West Road, Haidian District,
Beijing, 100193, People's Republic of China.
AU - Wang JQ
AD - Ministry of Agriculture - Laboratory of Quality and Safety Risk Assessment
for Dairy Products (Beijing), No. 2, Yuan Ming Yuan West Road, Haidian District,
Beijing, 100193, People's Republic of China.
AU - Zhang WJ
AD - College of Animal Science and Technology, Shihezi University, No. 4, the
North Road, Shihezi, Xinjiang, 832002, People's Republic of China.
Zhangwj1022@sina.com.
SO - Biol Trace Elem Res. 2018, May; 183(1):92-101. [Biological trace element
research]
AB - The object of this study is to analyze the levels of seven toxic elements
residues in raw bovine milk in China and assess the potential health risk
of those residues. The 178 raw bovine milk samples were collected from
eight main milk-producing provinces and from three types of milk stations
in China, and were analyzed for arsenic (As), lead (Pb), cadmium (Cd),
chromium (Cr), mercury (Hg), aluminum (Al), and nickel (Ni) using
inductively coupled plasma-mass spectrometry (ICP-MS). Al, Pb, Hg, Ni, Cr,
and As were detected in 47.8, 29.2, 28.1, 23.6, 12.4, and 9.0% of total
milk samples, respectively, and Cd were not detected in all samples. The
raw bovine milk samples with high levels of toxic elements were found in
industrial areas, such as Heilongjiang and Shanxi. Nemerow pollution index
analysis showed that the levels were lower in the samples from the
processing plants than that from the large-scale farms and small farm
cooperatives. The margin of exposure (MOE) values suggest that the levels
of As, Pb, Hg, Cr, Al, and Ni in the raw milk samples are not causing a
health risk for Chinese consumers, including adults and children.
Nevertheless, the risk of Pb for infant and young children was more
serious than adult.
KW - China
KW - ICP-MS
KW - Raw bovine milk
KW - Risk assessment
KW - Toxic elements
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180406
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170819
STAT- In-Process
DOCNO- medline/28825229

438 - TOXLINE
TI - Comparisons of human risk assessment models for heavy metal contamination
within abandoned metal mine areas in Korea.
AU - Lee SW
AD - Department of Geology and Research Institute of Natural Science (RINS),
Gyeongsang National University, Jinju, 52828, Republic of Korea.
AU - Cho HG
AD - Department of Geology and Research Institute of Natural Science (RINS),
Gyeongsang National University, Jinju, 52828, Republic of Korea.
AU - Kim SO
AD - Department of Geology and Research Institute of Natural Science (RINS),
Gyeongsang National University, Jinju, 52828, Republic of Korea. sokim@gnu.ac.kr.
SO - Environ Geochem Health. 2018, Apr 06. [Environmental geochemistry and
health]
AB - This study was initiated to develop a model specialized to conduct human
risk assessments (HRAs) of abandoned metal mine areas in Korea. The Korean
guideline (KG) model used in study was formulated via modification of the
original Korean guidelines on HRAs of soil contamination. In addition, the
newly developed model was applied to the HRAs of two abandoned metal mines
contaminated with arsenic (As) and heavy metals (Cd, Cu, Pb, and Zn). The
results of the KG model were compared with those of two internationally
renowned models [Contaminated land exposure assessment (CLEA) and CSOIL
models]. The HRA results of the three models indicated that the areas of
concern were unsafe when it came to both carcinogenic and non-carcinogenic
hazards. Furthermore, the hazards in both areas were mostly attributed to
As and the predominant exposure pathways were identified as crop intake in
the KG model and surface soil dermal contact in CLEA and CSOIL models.
Accordingly, measures to protect against As exposure should be established
immediately to prevent adverse health effects on inhabitants in these
areas. A comparison of HRA results revealed significant differences
between KG, CLEA, and CSOIL models due to the various types of exposure
pathways, contaminants, and input data, such as exposure factors and
receptor parameters. This study suggests that set-up of an exposure
scenario is crucial for the successful performance of HRAs, and the most
relevant HRA model should be deliberately selected to attain risk
assessment goals.
KW - Abandoned mine
KW - Carcinogenic risk
KW - Heavy metal contamination
KW - Human risk assessment
KW - Non-carcinogenic risk
KW - Remediation level
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180406
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20180406
STAT- Publisher
DOCNO- medline/29623519

439 - TOXLINE
TI - A comprehensive study including monitoring, assessment of health effects
and development of a remediation method for chromium pollution.
AU - Yoshinaga M
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan.
AU - Ninomiya H
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan; Voluntary Body for International
Healthcare in Universities, Nagoya, Aichi, Japan.
AU - Al Hossain MMA
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan; Voluntary Body for International
Healthcare in Universities, Nagoya, Aichi, Japan.
AU - Sudo M
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan; Voluntary Body for International
Healthcare in Universities, Nagoya, Aichi, Japan.
AU - Akhand AA
AD - Department of Genetic Engineering and Biotechnology, University of Dhaka,
Dhaka, Bangladesh.
AU - Ahsan N
AD - Department of Genetic Engineering and Biotechnology, University of Dhaka,
Dhaka, Bangladesh.
AU - Alim MA
AD - Institute of Public Health Nutrition, Directorate General of Health Services,
Dhaka, Bangladesh.
AU - Khalequzzaman M
AD - Department of Public Health and Informatics, Bangabandhu Sheikh Mujib Medical
University, Dhaka, Bangladesh.
AU - Iida M
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan; Voluntary Body for International
Healthcare in Universities, Nagoya, Aichi, Japan; Units of Environmental Health
Sciences, Department of Biomedical Sciences, College of Life and Health Sciences,
Chubu University, Kasugai, Aichi, Japan.
AU - Yajima I
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan; Voluntary Body for International
Healthcare in Universities, Nagoya, Aichi, Japan; Units of Environmental Health
Sciences, Department of Biomedical Sciences, College of Life and Health Sciences,
Chubu University, Kasugai, Aichi, Japan.
AU - Ohgami N
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan; Voluntary Body for International
Healthcare in Universities, Nagoya, Aichi, Japan; Units of Environmental Health
Sciences, Department of Biomedical Sciences, College of Life and Health Sciences,
Chubu University, Kasugai, Aichi, Japan.
AU - Kato M
AD - Department of Occupational and Environmental Health, Nagoya University
Graduate School of Medicine, Nagoya, Aichi, Japan; Voluntary Body for International
Healthcare in Universities, Nagoya, Aichi, Japan; Units of Environmental Health
Sciences, Department of Biomedical Sciences, College of Life and Health Sciences,
Chubu University, Kasugai, Aichi, Japan. Electronic address: katomasa@med.nagoya-
u.ac.jp.
SO - Chemosphere. 2018, Jun; 201:667-675. [Chemosphere]
AB - Chromium (Cr) pollution caused by wastewater from tanneries is a worldwide
environmental problem. To develop a countermeasure, we performed a
comprehensive study using Hazaribagh, the tannery area in Dhaka City,
Bangladesh, as a model. Our environmental monitoring indicated that the
soluble form of Cr, but not barium or arsenic, in Buriganga River is
derived from Hazaribagh. Our chemical analysis next showed that Cr, the
primary pollutant in canal water at Hazaribagh, consisted of
&le;0.7&#8239;&mu;M hexavalent Cr [Cr(VI)] and &le;1705&#8239;&mu;M
trivalent Cr [Cr(III)]. Our biological study then showed that coexposure
to Cr(VI) and Cr(III) at possible ratios in canal water at Hazaribagh
synergistically promotes transforming activity of human non-tumorigenic
HaCaT keratinocytes with activated MEK/ERK and AKT. Our environmental
engineering study finally indicated that a magnesium and iron-based
hydrotalcite-like compound (MF-HT), our original depurative, can maximally
adsorb 9.0&#8239;mg/g Cr(VI) and 1041&#8239;mg/g Cr(III). Our results
suggested the importance of removal of Cr(III) as well as Cr(VI) by
showing that Cr(III), which is generally recognized as a chemical with low
toxicity, synergistically promoted carcinogenicity of a low level of
Cr(VI). Therefore, we propose the use of our original high-efficient and
low-cost depurative as a countermeasure to address the worldwide problem
of environmental Cr pollution.
KW - Carcinogenic toxicity
KW - Chromium
KW - Depurative
KW - Tannery waste
KW - Water pollution
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180404
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20180305
STAT- In-Process
DOCNO- medline/29547855

440 - TOXLINE
TI - Neurotoxicity Linked to Dysfunctional Metal Ion Homeostasis and Xenobiotic
Metal Exposure: Redox Signaling and Oxidative Stress.
AU - Garza-Lomb� C
AD - 2 Departamento de Medicina Gen�mica y Toxicolog�a Ambiental, Instituto de
Investigaciones Biom�dicas , Universidad Nacional Aut�noma de M�xico, Mexico City,
M�xico .
AU - Posadas Y
AD - 4 Departamentos de Qu�mica, Centro de Investigaci�n y de Estudios Avanzados
(CINVESTAV) , Mexico City, M�xico .
AU - Quintanar L
AD - 4 Departamentos de Qu�mica, Centro de Investigaci�n y de Estudios Avanzados
(CINVESTAV) , Mexico City, M�xico .
AU - Gonsebatt ME
AD - 2 Departamento de Medicina Gen�mica y Toxicolog�a Ambiental, Instituto de
Investigaciones Biom�dicas , Universidad Nacional Aut�noma de M�xico, Mexico City,
M�xico .
AU - Franco R
AD - 1 Redox Biology Center and School of Veterinary Medicine and Biomedical
Sciences, University of Nebraska-Lincoln , Lincoln, Nebraska.
SO - Antioxid Redox Signal. 2018, Jun 20; 28(18):1669-1703. [Antioxidants &
redox signaling]
AB - SIGNIFICANCE: Essential metals such as copper, iron, manganese, and zinc
play a role as cofactors in the activity of a wide range of processes
involved in cellular homeostasis and survival, as well as during organ and
tissue development. Throughout our life span, humans are also exposed to
xenobiotic metals from natural and anthropogenic sources, including
aluminum, arsenic, cadmium, lead, and mercury. It is well recognized that
alterations in the homeostasis of essential metals and an increased
environmental/occupational exposure to xenobiotic metals are linked to
several neurological disorders, including neurodegeneration and
neurodevelopmental alterations. Recent Advances: The redox activity of
essential metals is key for neuronal homeostasis and brain function.
Alterations in redox homeostasis and signaling are central to the
pathological consequences of dysfunctional metal ion homeostasis and
increased exposure to xenobiotic metals. Both redox-active and
redox-inactive metals trigger oxidative stress and damage in the central
nervous system, and the exact mechanisms involved are starting to become
delineated.
AB - CRITICAL ISSUES: In this review, we aim to appraise the role of essential
metals in determining the redox balance in the brain and the mechanisms by
which alterations in the homeostasis of essential metals and exposure to
xenobiotic metals disturb the cellular redox balance and signaling. We
focus on recent literature regarding their transport, metabolism, and
mechanisms of toxicity in neural systems.
AB - FUTURE DIRECTIONS: Delineating the specific mechanisms by which metals
alter redox homeostasis is key to understand the pathological processes
that convey chronic neuronal dysfunction in neurodegenerative and
neurodevelopmental disorders. Antioxid. Redox Signal. 28, 1669-1703.
KW - essential metals
KW - heavy metals
KW - neurodegeneration
KW - neurotoxicity
KW - redox
LA - eng
IS - 1557-7716 (Electronic)
PT - Journal Article
TA - Antioxid Redox Signal
YR - 2018
DATE- 20180523
CITO- NLM
CS - United States
FJT - Antioxidants &amp; redox signaling
EDAT- 20180328
STAT- In-Data-Review
DOCNO- medline/29402131

441 - TOXLINE
TI - C. elegans as a model in developmental neurotoxicology.
AU - Ruszkiewicz JA
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States. Electronic address:
joanna.ruszkiewicz@einstein.yu.edu.
AU - Pinkas A
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States.
AU - Miah MR
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States. Electronic address:
mahfuzur.miah@phd.einstein.yu.edu.
AU - Weitz RL
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States.
AU - Lawes MJA
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States.
AU - Akinyemi AJ
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States; Department of Biochemistry, Afe Babalola
University, Ado-Ekiti, Ekiti State, Nigeria. Electronic address:
ayodele.akinyemi@einstein.yu.edu.
AU - Ijomone OM
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States; Department of Anatomy, School of Health and Health
Technology, Federal University of Technology Akure (FUTA), Nigeria. Electronic
address: omamuyovwi.ijomone@einstein.edu.yu.
AU - Aschner M
AD - Department of Molecular Pharmacology, Albert Einstein College of Medicine,
Bronx, New York, United States. Electronic address:
michael.aschner@einstein.yu.edu.
SO - Toxicol Appl Pharmacol. 2018, Mar 14. [Toxicology and applied
pharmacology]
AB - Due to many advantages Caenorhabditis elegans (C. elegans) has become a
preferred model of choice in many fields, including neurodevelopmental
toxicity studies. This review discusses the benefits of using C. elegans
as an alternative to mammalian systems and gives examples of the uses of
the nematode in evaluating the effects of major known neurodevelopmental
toxins, including manganese, mercury, lead, fluoride, arsenic and
organophosphorus pesticides. Reviewed data indicates numerous similarities
with mammals in response to these toxins. Thus, C. elegans studies have
the potential to predict possible effects of developmental neurotoxicants
in higher animals, and may be used to identify new molecular pathways
behind neurodevelopmental disruptions, as well as new toxicants.
KW - C. elegans
KW - Manganese
KW - Mercury
KW - Neurodevelopment
KW - Neurotoxicity
KW - Pesticides
LA - eng
IS - 1096-0333 (Electronic)
PT - Journal Article
TA - Toxicol Appl Pharmacol
YR - 2018
DATE- 20180403
CI - Copyright &copy; 2018 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Toxicology and applied pharmacology
EDAT- 20180314
STAT- Publisher
DOCNO- medline/29550512

442 - TOXLINE
TI - Mobility of multiple heavy metalloids in contaminated soil under various
redox conditions: Effects of iron sulfide presence and phosphate
competition.
AU - Park JH
AD - Korea Institute of Geoscience and Mineral Resources (KIGAM), Republic of
Korea; Department of Environmental Engineering, Chungbuk National University,
Republic of Korea.
AU - Kim SJ
AD - Korea Institute of Geoscience and Mineral Resources (KIGAM), Republic of
Korea.
AU - Ahn JS
AD - Korea Institute of Geoscience and Mineral Resources (KIGAM), Republic of
Korea.
AU - Lim DH
AD - Department of Environmental Engineering, Chungbuk National University,
Republic of Korea.
AU - Han YS
AD - Korea Institute of Geoscience and Mineral Resources (KIGAM), Republic of
Korea. Electronic address: yshan@kigam.re.kr.
SO - Chemosphere. 2018, Apr; 197:344-352. [Chemosphere]
AB - The mobility of heavy metalloids including As, Sb, Mo, W, and Cr in soil
was investigated under both reducing and oxidizing conditions. The effects
of soil mineralogy and the presence of competitive anions were studied as
important factors affecting the mobility of these contaminants. Batch
experiments conducted with the addition of oxidized and fresh FeS
exhibited enhanced sorption rates for As and W under oxidizing conditions,
and for Mo under reducing conditions. The inhibitory effect of phosphate
on the sorption rates was most apparent for As and Mo under both oxidizing
and reducing conditions, while only a small phosphate effect was observed
for Sb and W. For Sb and W mobility, pH was determined to be the most
important controlling factor. The results of long-term batch experiments
revealed that differences in the mobility of metalloids, particularly As,
were also influenced by microbial activity in the oxidizing and reducing
conditions.
KW - Fe(III)-(hydr)oxides
KW - FeS
KW - Redox-sensitive elements
KW - Remobilization
RN - 0R0008Q3JB
RN - 81AH48963U
RN - E1UOL152H7
RN - N712M78A8G
RN - V9306CXO6G
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180523
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20180203
STAT- MEDLINE
DOCNO- medline/29407804

443 - TOXLINE
TI - Surface Fe(II)/Fe(III) Cycle Promoted Ultra-Highly Sensitive
Electrochemical Sensing of Arsenic(III) with Dumbbell-Like Au/Fe3O4
Nanoparticles.
AU - Li SS
AD - University of Science and Technology of China , Hefei 230026 , People's
Republic of China.
AU - Zhou WY
AD - University of Science and Technology of China , Hefei 230026 , People's
Republic of China.
AU - Jiang M
AD - University of Science and Technology of China , Hefei 230026 , People's
Republic of China.
AU - Guo Z
AD - University of Science and Technology of China , Hefei 230026 , People's
Republic of China.
AU - Liu JH
AD - University of Science and Technology of China , Hefei 230026 , People's
Republic of China.
AU - Zhang L
AD - Key Laboratory of Pesticide &amp; Chemical Biology of Ministry of Education,
Institute of Environmental Chemistry , Central China Normal University , Wuhan
430079 , People's Republic of China.
AU - Huang XJ
AD - University of Science and Technology of China , Hefei 230026 , People's
Republic of China.
SO - Anal Chem. 2018, Apr 03; 90(7):4569-4577. [Analytical chemistry]
AB - Developing a new ultrasensitive interface to detect As(III) is highly
desirable because of its seriously toxic and low concentration in drinking
water. Recently, Fe3O4 nanoparticles of high adsorption toward As(III)
become very promising to be such an interface, which is still limited by
the poor understanding of their surface physicochemical properties.
Herein, we report that dumbbell-like Au/Fe3O4 nanoparticles, when being
modified the screen-printed carbon electrode, can serve as an efficient
sensing interface for As(III) detection with an excellent sensitivity of
9.43 &mu;A ppb-1 and a low detection limit of 0.0215 ppb. These
outstanding records were attributed to the participation of Fe(II)/Fe(III)
cycle on Fe3O4 surface in the electrochemical reaction of As(III) redox,
as revealed by X-ray photoelectron spectroscopy, X-ray absorption near
edge structure, and extended X-ray absorption fine structure. This work
provides new insight into the mechanism of electroanalysis from the
viewpoint of surface active atoms, and also helps to predict the
construction of ultrahighly sensitive electrochemical sensors for other
heavy metal ions with nonprecious redox active materials.
LA - eng
IS - 1520-6882 (Electronic)
PT - Journal Article
TA - Anal Chem
YR - 2018
DATE- 20180403
CITO- NLM
CS - United States
FJT - Analytical chemistry
EDAT- 20180323
STAT- In-Data-Review
DOCNO- medline/29557638

444 - TOXLINE
TI - Toxic elements in hair and in vitro fertilization outcomes: A prospective
cohort study.
AU - Garc�a-Fortea P
AD - Equipo provincial de Inspecci�n de M�laga, Consejer�a de Salud de la Junta de
Andaluc�a, Calle C�rdoba 11, 29001 M�laga, Spain. Electronic address:
pedro.garcia.fortea@juntadeandalucia.es.
AU - Cohen-Corcia I
AD - Obstetrics and Gynaecology Research Group at Malaga Regional and University
Hospital (IBIMA), Avda. Arroyo de los �ngeles, s/n, 29011 M�laga, Spain. Electronic
address: icohenc@gmail.es.
AU - C�rdoba-Do�a JA
AD - Delegaci�n Territorial de la Consejer�a de Salud de la Junta de Andaluc�a en
C�diz, Avenida Mar�a Auxiliadora 2, C�diz, Spain. Electronic address:
jantonio.cordoba@juntadeandalucia.es.
AU - Reche-Rosado A
AD - Obstetrics and Gynaecology Research Group at Malaga Regional and University
Hospital (IBIMA), Avda. Arroyo de los �ngeles, s/n, 29011 M�laga, Spain.
AU - Gonz�lez-Mesa E
AD - Obstetrics and Gynaecology Research Group at Malaga Regional and University
Hospital (IBIMA), Avda. Arroyo de los �ngeles, s/n, 29011 M�laga, Spain.
SO - Reprod Toxicol. 2018, Apr; 77:43-52. [Reproductive toxicology (Elmsford,
N.Y.)]
AB - We analysed the association between the concentration of four toxic
elements (As, Cd, Hg and Pb) and diverse reproductive outcomes in a cohort
of 194 women with fertility disorders undergoing IVF in a public hospital.
Concentration in hair specimens was explored as biomarker of exposure
during the three months prior to oocyte retrieval. The proportion of
negative results, especially regarding pregnancy and birth outcomes, is
remarkable. However, we found that the probability of mature oocytes was
inversely associated with the concentration of Hg in hair
(RR&#8239;=&#8239;0.81, 95% CI: 0.70-0.95) and directly associated with
that of Pb (RR&#8239;=&#8239;1.18, 95% CI: 1.03-1.35). These findings
provide insights for future research on the links between heavy metal
concentrations and IVF outcomes.
KW - Arsenic (As)
KW - Cadmium (Cd)
KW - Hair
KW - In vitro fertilization
KW - Lead (Pb)
KW - Mercury (Hg)
KW - Prospective cohort study
KW - Reproductive outcomes
LA - eng
IS - 1873-1708 (Electronic)
PT - Journal Article
TA - Reprod Toxicol
YR - 2018
DATE- 20180330
CI - Copyright &copy; 2018. Published by Elsevier Inc.
CITO- NLM
CS - United States
FJT - Reproductive toxicology (Elmsford, N.Y.)
EDAT- 20180210
STAT- In-Data-Review
DOCNO- medline/29438736

445 - TOXLINE
TI - Silicon improves growth and alleviates oxidative stress in rice seedlings
(Oryza sativa L.) by strengthening antioxidant defense and enhancing
protein metabolism under arsanilic acid exposure.
AU - Geng A
AD - Research Center of Trace Elements (Guangzhou), Huazhong Agricultural
University, Guangzhou 510640, Guangdong, PR China; Public Monitoring Center for
Agro-product of Guangdong Academy of Agricultural Sciences, Guangzhou 510640,
Guangdong, PR China.
AU - Wang X
AD - Research Center of Trace Elements (Guangzhou), Huazhong Agricultural
University, Guangzhou 510640, Guangdong, PR China; Public Monitoring Center for
Agro-product of Guangdong Academy of Agricultural Sciences, Guangzhou 510640,
Guangdong, PR China.
AU - Wu L
AD - College of resource and environment, Huazhong Agricultural University, Wuhan
430070, Hubei, PR China.
AU - Wang F
AD - Research Center of Trace Elements (Guangzhou), Huazhong Agricultural
University, Guangzhou 510640, Guangdong, PR China; Public Monitoring Center for
Agro-product of Guangdong Academy of Agricultural Sciences, Guangzhou 510640,
Guangdong, PR China. Electronic address: wfhwqs@163.com.
AU - Wu Z
AD - Public Monitoring Center for Agro-product of Guangdong Academy of
Agricultural Sciences, Guangzhou 510640, Guangdong, PR China; Key Laboratory of
Testing and Evaluation for Agro-Product Safety and Quality, Ministry of
Agriculture, PR China, Guangzhou 510640, Guangdong, PR China.
AU - Yang H
AD - Research Center of Trace Elements (Guangzhou), Huazhong Agricultural
University, Guangzhou 510640, Guangdong, PR China; Key Laboratory of Testing and
Evaluation for Agro-Product Safety and Quality, Ministry of Agriculture, PR China,
Guangzhou 510640, Guangdong, PR China.
AU - Chen Y
AD - Research Center of Trace Elements (Guangzhou), Huazhong Agricultural
University, Guangzhou 510640, Guangdong, PR China; Key Laboratory of Testing and
Evaluation for Agro-Product Safety and Quality, Ministry of Agriculture, PR China,
Guangzhou 510640, Guangdong, PR China.
AU - Wen D
AD - Public Monitoring Center for Agro-product of Guangdong Academy of
Agricultural Sciences, Guangzhou 510640, Guangdong, PR China.
AU - Liu X
AD - Public Monitoring Center for Agro-product of Guangdong Academy of
Agricultural Sciences, Guangzhou 510640, Guangdong, PR China.
SO - Ecotoxicol Environ Saf. 2018, Aug 30; 158:266-273. [Ecotoxicology and
environmental safety]
AB - Organoarsenic arsanilic acid (ASA) contamination of paddy soil is a
serious but less concerned hazard to agriculture and health of people
consuming rice as staple food, for rice is one major pathway of arsenic
(As) exposure to human food. To date little research has studied the
effect of ASA on biochemical process of rice. Silicon (Si) application is
able to reduce the toxicities of heavy metals in numerous plants, but
little information about ASA. This work investigated whether and how Si
influenced alleviation of ASA toxicity in rice at biochemical level to
have a better understanding of defense mechanism by Si against ASA stress.
Results showed that ASA reduced rice growth, disturbed protein metabolism,
increased lipid peroxidation but decreased the efficiencies of antioxidant
activities compared to control plants, more severe in roots than in
shoots. The addition of Si in ASA-stressed rice plants noticeably
increased growth and development as well as soluble protein contents, but
decreased malondialdehyde (MDA) contents in ASA-stressed rice plants,
suggesting that Si did have critical roles in ASA detoxification in rice.
Furthermore, increased superoxide dismutase (SOD), catalase (CAT) and
peroxidase (POD) activities along with elevated glutathione (GSH) and
ascorbic acid (AsA) contents implied the active involvement of ROS
scavenging and played, at least in part, to Si-mediated alleviation of ASA
toxicity in rice, and these changes were related to rice genotypes and
tissues. The study provided physio-chemical mechanistic evidence on the
beneficial effect of Si on organoarsenic ASA toxicity in rice seedlings.
KW - Arsanilic acid
KW - Growth
KW - Oxidative stress
KW - Rice
KW - Silicon
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180522
CI - Copyright &copy; 2018. Published by Elsevier Inc.
CITO- NLM
CS - Netherlands
FJT - Ecotoxicology and environmental safety
EDAT- 20180430
STAT- In-Process
DOCNO- medline/29715631

446 - TOXLINE
TI - Characterization and Antimicrobial Property of Some Heavy Metals
Containing Ayurvedic Drugs.
AU - Panta P
AD - Research Centre for Applied Science and Technology (RECAST), Tribhuvan
University, Kathmandu, Kirtipur, Nepal.
AU - Bhandari TR
AD - Research Centre for Applied Science and Technology (RECAST), Tribhuvan
University, Kathmandu, Kirtipur, Nepal.
AU - Lamsal B
AD - Research Centre for Applied Science and Technology (RECAST), Tribhuvan
University, Kathmandu, Kirtipur, Nepal.
AU - Adhikari R
AD - Research Centre for Applied Science and Technology (RECAST), Tribhuvan
University, Kathmandu, Kirtipur, Nepal. nepalpolymer@yahoo.com.
SO - Adv Exp Med Biol. 2018; 1052:75-81. [Advances in experimental medicine and
biology]
AB - Ayurvedic medicines are often used in different formulations, the heavy
metals, which are generally referred to as being toxic. In this work, we
report on the physicochemical characterization and biological activity of
some typical Ayurvedic drugs available in the market that contain arsenic,
mercury and lead with the emphasis on their antibacterial performance.
Among the formulations studied, some of the drugs with 'amorphous' texture
(and higher solubility) were found quite active against some bacterial
strains whereas the formulations possessing crystalline texture (and low
solubility) were found practically ineffective. The moderate activity of
some drugs against Gram-negative bacteria fairly suggested the presence of
the small-sized polar molecules which was also supported by the FTIR
spectroscopic data.
KW - Antimicrobial agent
KW - Ayurvedic drug
KW - FTIR
KW - Heavy metal
KW - Microscopy
LA - eng
IS - 0065-2598 (Print)
PT - Journal Article
TA - Adv Exp Med Biol
YR - 2018
DATE- 20180522
CITO- NLM
CS - United States
FJT - Advances in experimental medicine and biology
STAT- In-Data-Review
DOCNO- medline/29785482

447 - TOXLINE
TI - Heavy metal contamination in soils and vegetables and health risk
assessment of inhabitants in Daye, China.
AU - Yang J
AD - 2 School of Information and Safety Engineering, 12445 Zhongnan University of
Economics and Law.
AU - Ma S
AD - 2 School of Information and Safety Engineering, 12445 Zhongnan University of
Economics and Law.
AU - Zhou J
AD - 2 School of Information and Safety Engineering, 12445 Zhongnan University of
Economics and Law.
AU - Song Y
AD - 2 School of Information and Safety Engineering, 12445 Zhongnan University of
Economics and Law.
AU - Li F
AD - 2 School of Information and Safety Engineering, 12445 Zhongnan University of
Economics and Law.
SO - J Int Med Res. 2018, Jan 01:300060518758585. [The Journal of international
medical research]
AB - Objective This study was performed to evaluate the state of heavy metal
contamination in soil and vegetables and assess the health risk of
inhabitants in the mine-affected area and area far from the mine
(reference area) in Daye, China. Methods The heavy metal concentrations in
soil and vegetable samples were detected by inductively coupled plasma
mass spectrometry. Residents' exposure parameters were obtained through a
questionnaire survey. A health risk assessment model recommended by the
United States Environmental Protection Agency was used to evaluate the
residents' risk of oral exposure. Results The copper, lead, cadmium, and
arsenic concentrations in soil and in vegetables were higher in the
mine-affected area than in the reference area. The health risk of
residents in the reference area was within the acceptable range (hazard
index&thinsp; < &thinsp;1, carcinogen risk&thinsp; < &thinsp;10-4). In
the contaminated area, however, the mean hazard index was 2.25 for
children and 3.00 for adults, and the mean carcinogen risk was
4.749&thinsp;&times;&thinsp;10-4 for children and
0.587&thinsp;&times;&thinsp;10-4 for adults. Conclusions Potential health
risks exist for inhabitants near the mine area. Cadmium and arsenic should
be paid more attention as risk sources.
KW - Daye
KW - Heavy metal
KW - carcinogen risk
KW - hazard index
KW - health risk assessment
KW - soil
KW - vegetable
LA - eng
IS - 1473-2300 (Electronic)
PT - Journal Article
TA - J Int Med Res
YR - 2018
DATE- 20180328
CITO- NLM
CS - England
FJT - The Journal of international medical research
EDAT- 20180101
STAT- Publisher
DOCNO- medline/29557292

448 - TOXLINE
TI - A systematic review and meta-analysis of metal concentrations in canned
tuna fish in Iran and human health risk assessment.
AU - Rahmani J
AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food
Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AU - Fakhri Y
AD - Department of Environmental Health Engineering, Student Research Committee,
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran,
Iran. Electronic address: Ya.fakhri@gmail.com.
AU - Miri A
AD - Department of Nutrition, School of Health, Zabol University of Medical
Sciences, Zabol, Iran.
AU - Shahsavani A
AD - Environmental and Occupational Hazards Control Research Center, Shahid
Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:
Ashahsavani@sbmu.ac.ir.
AU - Bahmani Z
AD - Environmental Health Engineering, Developmental Center for Student Research
and Technology Talent, Faculty of School of Public Health Branch, Iran University
of Medical Sciences, Tehran, Iran.
AU - Urbina MA
AD - Departamento de Zoolog�a, Facultad de Ciencias Naturales y Oceanogr�ficas,
Universidad de Concepci�n, Casilla 160-C, Concepci�n, Chile.
AU - Chirumbolo S
AD - Department of Neurological and Movement Sciences, University of Verona,
Italy.
AU - Keramati H
AD - Department of Environmental Health Engineering, School of Public Health,
Semnan University of Medical Sciences, Semnan, Iran.
AU - Moradi B
AD - Research Center for Environmental Determinants of Health (RCEDH), Kermanshah
University of Medical Sciences, Kermanshah, Iran.
AU - Bay A
AD - Environmental Health Research Center, Golestan University of Medical
Sciences, Golestan, Iran.
AU - Bj�rklund G
AD - Council for Nutritional and Environmental Medicine, Mo i Rana, Norway.
Electronic address: bjorklund@conem.org.
SO - Food Chem Toxicol. 2018, Jun 15. [Food and chemical toxicology : an
international journal published for the British Industrial Biological
Research Association]
AB - Human consumption of fish protein, including canned tuna fish, is
increasing steadily worldwide. However, there are some concerns about the
potential exposure to elevated concentrations of metals in canned tuna
fish. Several studies have been conducted in Iran regarding the
concentration of metals in seafood, including copper (Cu), selenium (Se),
iron (Fe), zinc (Zn), mercury (Hg), lead (Pb), chromium (Cr), arsenic
(As), nickel (Ni), tin (Sn), and cadmium (Cd) in canned tuna fish. The
main aim of this study was to gather data from existing papers and to
perform a meta-analysis of the pooled concentrations of metals to evaluate
their non-carcinogenic and carcinogenic risks in children and adults
consumers. Search was conducted retrieving data from the international
biomedical databases with highly public access and consultation, e.g., Web
of Science, PubMed, Science Direct, and Scopus, and national database (SID
and Irandoc) between 1983 and November of 2017. Data from 23 articles and
1295 samples were assessed and extracted. The ranking order of metals
based on mean concentrations (&mu;g/g wet weight) were Fe
(13.17)&#8239; > &#8239;Zn (9.31)&#8239; > &#8239;Se
(2.23)&#8239; > &#8239;Al (1.8)&#8239; > &#8239;Cr
(1.63)&#8239; > &#8239;Cu (1.52)&#8239; > &#8239;As
(0.38)&#8239; > &#8239;Ni (0.33)&#8239; > &#8239;Pb
(0.24)&#8239; > &#8239;Cd (0.14)&#8239; > &#8239;Hg
(0.11)&#8239; > &#8239;Sn (0.1). Except for Cd and Se, concentrations of
other metals in the canned tuna fish were lower than the limits
recommended by the United States Environmental Protection Agency (USEPA),
World Health Organization (WHO), Food and Agriculture Organization (FAO)
and Iran National Standards Organization (INSO). The minimum and maximum
target hazard quotient (THQ) for adults were 5.55E-5 for Al and 2.23E-08
for Cr. For children, they were 7.23E-05 for Al and 2.91E-08 for Cr. THQ,
and total target hazard quotient (TTHQ) were &le;1.0 for adult and
children consumers. The Incremental Lifetime Cancer Risk (ILCR) of As was
3.21E-5 in adults and 4.18E-5 in children. Adults and children that
consume canned tuna fish in Iran are not at non-carcinogenic risk but have
a carcinogenic risk due to As.
KW - Canned tuna
KW - Food safety
KW - Heavy metal
KW - Iran
KW - Risk assessment
KW - Systematic review
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180618
CI - Copyright &copy; 2018. Published by Elsevier Ltd.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180615
STAT- Publisher
DOCNO- medline/29913231

449 - TOXLINE
TI - A DOC coagulant, gypsum treatment can simultaneously reduce As, Cd and Pb
uptake by medicinal plants grown in contaminated soil.
AU - Kim HS
AD - Department of Biological Environment, Kangwon National University, Chuncheon-
si, Gangwon-do 24341, Republic of Korea.
AU - Seo BH
AD - Department of Agronomy and Medicinal Plant Resources, Gyeongnam National
University of Science and Technology, Jinju 52725, Republic of Korea.
AU - Kuppusamy S
AD - Institute of Agriculture and Life Science, Gyeongsang National University,
Jinju 52828, Republic of Korea.
AU - Lee YB
AD - Institute of Agriculture and Life Science, Gyeongsang National University,
Jinju 52828, Republic of Korea.
AU - Lee JH
AD - Technical Review &amp; Quality Management Institute, Korea Rural Community
Corporation, Daejeon-si 35260, Republic of Korea.
AU - Yang JE
AD - Department of Biological Environment, Kangwon National University, Chuncheon-
si, Gangwon-do 24341, Republic of Korea.
AU - Owens G
AD - Environmental Contaminants Group, Future Industries Institute, University of
South Australian, Mawson Lakes, SA 5095, Australia.
AU - Kim KR
AD - Department of Agronomy and Medicinal Plant Resources, Gyeongnam National
University of Science and Technology, Jinju 52725, Republic of Korea. Electronic
address: kimkr419@gntech.ac.kr.
SO - Ecotoxicol Environ Saf. 2018, Feb; 148:615-619. [Ecotoxicology and
environmental safety]
AB - The efficiency of gypsum, as a dissolved organic carbon (DOC) coagulator,
for the simultaneous immobilization of two heavy metals (Cd and Pb) and
one metalloid (As) in agricultural soils near an abandoned mining site was
examined. The agricultural soil was defined as long-term contaminated as
As (1540mgkg-1), Cd (55mgkg-1) and Pb (1283mgkg-1) concentrations exceeded
the Korean guideline values for As (25mgkg-1), Cd (4mgkg-1), and Pb
(200mgkg-1). Gypsum was incorporated into the contaminated soil at 3%
(w/w). In comparison two commonly using immobilizing agents (lime and
compost), together with a mixture (lime+gypsum) were also included in the
pot trial for the cultivation of two medical plants (A. gigas and A.
macrocephala) and to evaluate the effectiveness of gypsum on As, Cd and Pb
immobilization. The results showed that even though pH change-induced
immobilizing agents such as lime were more effective than gypsum at
immobilizing Cd and Pb, addition of gypsum also effectively reduced heavy
metal phytoavailability as indicated by decreases in the concentration of
Cd and Pb in medicinal plants. Furthermore, gypsum and gypsum+ lime were
also most effective in reducing As concentrations in both plants studied.
This was mainly attributed to significant decreases in soil DOC (48-64%)
when gypsum and gypsum+lime were applied to the soil. Consequently, it was
concluded that enhanced DOC coagulation with gypsum, could be considered
as a promising technique for the immobilization of both metals (Cd and Pb)
and metalloids (As) in agricultural soils.
KW - Compost
KW - Heavy metals
KW - Immobilization
KW - Lime
KW - Metalloid
KW - Stabilization
RN - 00BH33GNGH
RN - 2P299V784P
RN - 7440-44-0
RN - C7X2M0VVNH
RN - N712M78A8G
RN - WAT0DDB505
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180518
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20171109
STAT- MEDLINE
DOCNO- medline/29128822

450 - TOXLINE
TI - The role of heavy metals and polychlorinated biphenyls (PCBs) in the
oncogenesis of head and neck tumors and thyroid diseases: a pilot study.
AU - Petrosino V
AD - ASL Salerno, Salerno, Italy. petrosino8@virgilio.it.
AU - Motta G
AD - ENT Clinic, University of Naples, via S. Pansini, 5, 80131, Naples, Italy.
AU - Tenore G
AD - Pharmaceutical Chemistry, University of Naples, Via Domenico Montesano, 49,
80131, Naples, Italy.
AU - Coletta M
AD - ENT Clinic, University of Naples, via S. Pansini, 5, 80131, Naples, Italy.
AU - Guariglia A
AD - ENT Clinic, University of Naples, via S. Pansini, 5, 80131, Naples, Italy.
AU - Testa D
AD - ENT Clinic, University of Naples, via S. Pansini, 5, 80131, Naples, Italy.
SO - Biometals. 2018, Apr; 31(2):285-295. [Biometals : an international journal
on the role of metal ions in biology, biochemistry, and medicine]
AB - Previous literature has highlighted the mechanisms of molecular toxicity
induced by substances such as arsenic, cadmium, chromium, nickel, lead,
barium and PCBs. The research was carried out on 20 volunteers, all the
patients gave their consent to the research: the aim of the study was to
evaluate the presence of metals and PCBs in these different matrices
(blood and hair), correlating the biochemical data to pathological
conditions present, and also to the area in which patients resided.
Various quantitative determinations were carried out on samples of blood
and hair for 14 heavy metals and on blood samples for 12 PCBs. For the 11
patients the results indicated that blood levels for half of the 14
displayed heavy metals measured considerably higher compared to the
reference values, whilst the levels measured in hair evidenced some
positive values significantly higher than the maximum reference. Of the 12
PCBs assayed in blood some showed higher positive values compared to the
maximum tabular reference (although there is no clear reference quantified
in the WHO-2005 report). In the 9 healthy patients heavy metals in the
blood were within the expected target range, with those showing positive
results (&le; 3 out of 14 heavy metals for each patient) having
values only slightly higher than the reference maximum. The levels of 14
heavy metals measured in hair were below thresholds, and levels for the 12
PCBs measured in blood showed negativity or positivity with values close
to the minimum benchmarks. The analyses carried out on biological matrices
have uncovered important and significant differences between healthy and
unhealthy subjects, both qualitative and quantitative differences with
respect to heavy metals and PCBs. All patients with head and neck cancer
enlisted for the study had heavy metal and PCB blood levels at least twice
the maximum reference level. The levels of heavy metals in hair were at
least double the maximum reference. In contrast, all healthy volunteers
enrolled showed no significant levels for either metals or PCBs.
KW - Head and neck tumors
KW - Heavy metals
KW - Oncogenesis
KW - PCB
LA - eng
IS - 1572-8773 (Electronic)
PT - Journal Article
TA - Biometals
YR - 2018
DATE- 20180323
CITO- NLM
CS - Netherlands
FJT - Biometals : an international journal on the role of metal ions in biology,
biochemistry, and medicine
EDAT- 20180308
STAT- In-Data-Review
DOCNO- medline/29520558

451 - TOXLINE
TI - Minimizing the risk to human health due to the ingestion of arsenic and
toxic metals in vegetables by the application of biochar, farmyard manure
and peat moss.
AU - Nawab J
AD - Key Laboratory of Tibetan Land Surface Processes, Institute of Tibetan
Plateau Research, Chinese Academy of Sciences, Beijing 100085, China; University of
Chinese Academy of Sciences, Beijing 100049, China; Department of Environmental
Sciences, Abdul Wali Khan University Mardan, Pakistan.
AU - Ghani J
AD - Department of Environmental and Conservation Sciences, University of Swat,
Swat 19130, Pakistan.
AU - Khan S
AD - Department of Environmental Sciences, University of Peshawar, Pakistan.
Electronic address: sardar.khan2008@yahoo.com.
AU - Xiaoping W
AD - Key Laboratory of Tibetan Land Surface Processes, Institute of Tibetan
Plateau Research, Chinese Academy of Sciences, Beijing 100085, China; University of
Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
wangxp@itpcas.ac.cn.
SO - J Environ Manage. 2018, May 15; 214:172-183. [Journal of environmental
management]
AB - Mining activity releases toxic metals (TMs) into the soil ecosystem and
creates serious problems for the environment and human beings due to their
adverse eco-toxilogical impacts. Currently, several remediation techniques
can be used to immobilize TMs within contaminated soil. The present study
focuses on the application of different organic amendments biochar (B),
farmyard manure (FYM) and peat moss (PTM) - at different application rates
(1%, 2% and 5%) in mining-impacted agricultural soil to immobilize TMs
(Ni, Cr, As, Zn, Cd and Pb) and minimize their bioaccumulation in pea
(Pisum sativum) and chili (Capsicum annuum) and the associated human
health risk. Among the organic amendments, the treatments at the 5%
application rate of B, FYM and PTM significantly
(p&#8239;&le;&#8239;0.001) reduced the bioavailability of TM
concentrations in amended soil and increased pea and chili plants' and
fruits' biomasses when compared with the control. Moreover, risk
assessments showed that B, FYM and PTM decreased the daily intake and
health risk associated with the consumption of vegetables effectively for
individual TMs compared with the control. The highest application rate of
5% significantly (p&#8239;&le;&#8239;0.001) reduced the average daily
intake of TMs and their health risk, as compared to 1% and 2%, for both
adults and children. The health risk index (HRI &#706; 1) values were
lower (and within safety limits) for adults and children consuming
vegetables grown on organic-amended soils. The results indicate that the
B5% treatment of this mining-impacted agricultural soil was the most
efficient at increasing plant and fruit biomasses and reducing the
bioavailability, bioaccumulation and daily intake of TMs and their
potential health risk through consumption of vegetables such as pea and
chili, as compared to FYM, PTM and the control treatment.
KW - Biomass
KW - Human health risk
KW - Mining-impacted agricultural soil
KW - Organic amendment
KW - Vegetables
LA - eng
IS - 1095-8630 (Electronic)
PT - Journal Article
TA - J Environ Manage
YR - 2018
DATE- 20180320
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Journal of environmental management
EDAT- 20180308
STAT- In-Process
DOCNO- medline/29525749

452 - TOXLINE
TI - Evaluation of trace element status of organic dairy cattle.
AU - Orjales I
AD - 1Departamento de Anatom�a,Produci�n Animal e Ciencias Cl�nicas Veterinarias,
Facultad de Veterinaria,Universidade de Santiago de Compostela,27002 Lugo,Spain.
AU - Herrero-Latorre C
AD - 2Departamento de Qu�mica Anal�tica,Nutrici�n e Bromatolox�a, Facultad de
Ciencias,Universidade de Santiago de Compostela,27002 Lugo,Spain.
AU - Miranda M
AD - 1Departamento de Anatom�a,Produci�n Animal e Ciencias Cl�nicas Veterinarias,
Facultad de Veterinaria,Universidade de Santiago de Compostela,27002 Lugo,Spain.
AU - Rey-Crespo F
AD - 3Centro Tecnol�xico Agroalimentario de Lugo (CETAL),27002 Lugo,Spain.
AU - Rodr�guez-Berm�dez R
AD - 4Departamento de Patolox�a Animal, Facultad de Veterinaria,Universidade de
Santiago de Compostela,27002 Lugo,Spain.
AU - L�pez-Alonso M
AD - 4Departamento de Patolox�a Animal, Facultad de Veterinaria,Universidade de
Santiago de Compostela,27002 Lugo,Spain.
SO - Animal. 2018, Jun; 12(6):1296-1305. [Animal : an international journal of
animal bioscience]
AB - The present study aimed to evaluate trace mineral status of organic dairy
herds in northern Spain and the sources of minerals in different types of
feed. Blood samples from organic and conventional dairy cattle and feed
samples from the respective farms were analysed by inductively coupled
plasma mass spectrometry to determine the concentrations of the essential
trace elements (cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), iodine
(I), manganese (Mn), molybdenum (Mo), nickel (Ni), selenium (Se) and zinc
(Zn)) and toxic trace elements (arsenic (As), cadmium (Cd), mercury (Hg)
and lead (Pb)). Overall, no differences between organic and conventional
farms were detected in serum concentrations of essential and toxic trace
elements (except for higher concentrations of Cd on the organic farms),
although a high level of inter-farm variation was detected in the organic
systems, indicating that organic production greatly depends on the
specific local conditions. The dietary concentrations of the essential
trace elements I, Cu, Se and Zn were significantly higher in the
conventional than in the organic systems, which can be attributed to the
high concentration of these minerals in the concentrate feed. No
differences in the concentrations of trace minerals were found in the
other types of feed. Multivariate chemometric analysis was conducted to
determine the contribution of different feed sources to the trace element
status of the cattle. Concentrate samples were mainly associated with Co,
Cu, I, Se and Zn (i.e. with the elements supplemented in this type of
feed). However, pasture and grass silage were associated with soil-derived
elements (As, Cr, Fe and Pb) which cattle may thus ingest during grazing.
KW - dairy cow nutrition
KW - forage
KW - organic farming
KW - soil ingestion
KW - trace element status
LA - eng
IS - 1751-732X (Electronic)
PT - Journal Article
TA - Animal
YR - 2018
DATE- 20180518
CITO- NLM
CS - England
FJT - Animal : an international journal of animal bioscience
EDAT- 20171106
STAT- In-Process
DOCNO- medline/29103395

453 - TOXLINE
TI - Arsenic and trace elements in soil, water, grapevine and onion in
J�chal, Argentina.
AU - Funes Pinter I
AD - Instituto de Biolog�a Agr�cola de Mendoza (IBAM, CONICET-UNCuyo), Almirante
Brown 500, M5528AHB Chacras de Coria, Argentina. Electronic address:
ifunespinter@fca.uncu.edu.ar.
AU - Salomon MV
AD - Instituto de Biolog�a Agr�cola de Mendoza (IBAM, CONICET-UNCuyo), Almirante
Brown 500, M5528AHB Chacras de Coria, Argentina. Electronic address:
msalomon@fca.uncu.edu.ar.
AU - Gil R
AD - Instituto de Qu�mica de San Luis (INQUISAL, CONICET-UNSL), Chacabuco y
Pedernera, D5700HOI San Luis, Argentina. Electronic address: ragil@unsl.edu.ar.
AU - Mastrantonio L
AD - C�tedra de Edafolog�a, Facultad de Ciencias Agrarias, UNCuyo, Almirante Brown
500, M5528AHB Chacras de Coria, Argentina. Electronic address: lmastra@uncu.edu.ar.
AU - Bottini R
AD - Instituto de Biolog�a Agr�cola de Mendoza (IBAM, CONICET-UNCuyo), Almirante
Brown 500, M5528AHB Chacras de Coria, Argentina. Electronic address:
rbottini@fca.uncu.edu.ar.
AU - Piccoli P
AD - Instituto de Biolog�a Agr�cola de Mendoza (IBAM, CONICET-UNCuyo), Almirante
Brown 500, M5528AHB Chacras de Coria, Argentina. Electronic address:
ppiccoli@fca.uncu.edu.ar.
SO - Sci Total Environ. 2018, Feb 15; 615:1485-1498. [The Science of the total
environment]
AB - Contamination by trace elements (TE) is an increasing concern worldwide.
In some areas, crop production could be limited by the presence of metals
and metalloids, so it is important to determine their concentrations and
mobility. The region of J�chal, province of San Juan, Argentina,
has good growing conditions for onion and grapevine production, but their
quality and yield are affected by high TE concentration in soils and
water. Soils, water, grapevine and onion were sampled and TE content
determined. In soils elevated As, B, Cr, Hg, and Tl concentrations were
detected (506&plusmn;46, 149&plusmn;3, 2714&plusmn;217, 16&plusmn;7, and
12&plusmn;3&mu;gg-1, respectively, for maximum values measured), and
physicochemical properties of the soil promotes these elements mobility.
Water samples had high As, B, Cr, and Fe concentrations (1438&plusmn;400,
10,871&plusmn;471, 11,516&plusmn;2363, and 3071&plusmn;257&mu;gL-1,
respectively, for maximum values measured) while in onion bulbs and
grapevine berries, As, Cr, Cu, and Fe (92&plusmn;7 and 171&plusmn;20,
1412&plusmn;18 and 2965&plusmn;32, 17&plusmn;3 and 126&plusmn;88, and
418&plusmn;204 and 377&plusmn;213&mu;gg-1, respectively, for maximum
values measured) exceeded the limits for food consumption established by
Argentinian law. Correlation analyses indicated that: i) there is a common
source of TE in this area, ii) each elements concentration in plants is
associated with different soil variables and different soils depths, and
iii) the lack of correlation between soil and water indicates that
concentration in water is not constant over the time and/or there exists a
differential accumulation of elements in soils depending on their own
properties. Data obtained demonstrate very high concentration of TE in
soil, grapevines, and onion plants in J�chal region, and different
remediation techniques are necessary to stabilize and minimize the
bioavailability of these elements.
KW - Correlation analysis
KW - ICP-MS
KW - Legal limits
KW - Toxic metals
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180316
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20170918
STAT- PubMed-not-MEDLINE
DOCNO- medline/28927807

454 - TOXLINE
TI - Geochemical behavior of fluoride-rich groundwater in Markapur, Andhra
Pradesh, South India.
AU - Sudarshan V
AD - Department of Applied Geochemistry, University College of Science, Osmania
University, Hyderabad 500007, India.
AU - Narsimha A
AD - Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region
of the Ministry of Education, Chang'an University, No. 126 Yanta Road, Xi'an
710054, Shaanxi, China.
AU - Das SVG
AD - Centre for Hydrological Education, Hyderabad 500010, India.
SO - Data Brief. 2018, Jun; 18:87-95. [Data in brief]
AB - Excess fluoride in drinking water has been one of the leading problem
faced by the arid and semi-arid regions of the world. Significantly in
India the people suffer from fluorosis comparing to other toxic elements
like Arsenic etc., in drinking water. Approximately, in India the
excessive fluoride in groundwater is noticed in 177 districts covering 21
states, affecting 66 million people, including 6 million children and
Moreover, the latest estimation gives nearly 200 million people, from
among 25 nations the world over, are affected by the deadly disease of
fluorosis [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12],
[13], [14]. The fluoride of the groundwater varies from 0.4 to
5.8&#8239;mg/L with a mean of 1.98&#8239;mg/L (Table 1 &amp; 2), which
indicates that the concentration of fluoride is not uniform in the study
area. In general intake of small quantities of fluoride in the permissible
limit of 0.5 to 1&#8239;mg/L is known to be beneficial for human health in
production and maintenance of proper health. However, in India safe limit
of fluoride in potable water is considered to be between 0.6 to
1.2&#8239;mg/L, less than 0.6&#8239;mg/L can cause dental caries, while
higher than 1.2&#8239;mg/L leads to fluorosis [1], [2], [3], [4], [5],
[6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16].
LA - eng
IS - 2352-3409 (Print)
PT - Journal Article
TA - Data Brief
YR - 2018
DATE- 20180615
CITO- NLM
CS - Netherlands
FJT - Data in brief
EDAT- 20180308
STAT- PubMed-not-MEDLINE
CM - Cites: Data Brief. 2017 Dec 06;16:717-723 (medline /29270454)
CM - Cites: Data Brief. 2017 Dec 06;16:752-757 (medline /29270457)
CM - Cites: Data Brief. 2017 Dec 06;16:693-699 (medline /29541666)
CM - Cites: Data Brief. 2018 Jan 31;17 :339-346 (medline /29876403)
DOCNO- medline/29896496

455 - TOXLINE
TI - Epigenetic mechanisms in developmental neurotoxicity.
AU - Raciti M
AD - Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden.
Electronic address: marilena.raciti@ki.se.
AU - Ceccatelli S
AD - Karolinska Institutet, Department of Neuroscience, Stockholm, Sweden.
SO - Neurotoxicol Teratol. 2018 Mar - Apr; 66:94-101. [Neurotoxicology and
teratology]
AB - The constant interplay between environment (including both exogenous and
endogenous factors) and epigenome (defined as the combination of
chromatin, its covalent modifications and noncoding RNAs) triggers
epigenetic events that, by modulating gene expression, capture information
about changes in the environment. In this mini review, we will focus on
the neurodevelopmental implications of exposure to adverse prenatal milieu
with emphasis on mechanistic and functional aspects. Several neurotoxic
insults have been shown to affect epigenetics with negative consequences
on the development of the nervous system; among them are methylmercury,
lead, arsenic and cadmium, as well as excess of glucocorticoids. Further
investigations on the individual susceptibility to epigenetic changes are
needed to propose and validate such modifications as possible biomarkers
for early identification of neurological/neurodevelopmental disorders and
for predicting/monitoring response to treatment.
LA - eng
IS - 1872-9738 (Electronic)
PT - Journal Article
PT - Review
TA - Neurotoxicol Teratol
YR - 2018
DATE- 20180316
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Neurotoxicology and teratology
EDAT- 20171206
STAT- In-Data-Review
DOCNO- medline/29221727

456 - TOXLINE
TI - Assessment of toxic metals in water and sediment of Pasur River in
Bangladesh.
AU - Ali MM
AD - Department of Aquaculture, Patuakhali Science and Technology University,
Patuakhali 8602, Bangladesh.
AU - Ali ML
AD - Department of Aquaculture, Patuakhali Science and Technology University,
Patuakhali 8602, Bangladesh; Centre for Research in Biotechnology for Agriculture,
University of Malaya, Kuala Lumpur 50603, Malaysia.
AU - Islam MS
AD - Department of Soil Science, Patuakhali Science and Technology University,
Patuakhali 8602, Bangladesh E-mail: msaifulpstu@yahoo.com; islam-md.saiful-
nj@ynu.jp.
AU - Rahman MZ
AD - Department of Fisheries, Fish Inspection and Quality Control Chemistry
Laboratory, Bangladesh.
SO - Water Sci Technol. 2018, Mar; 77(5-6):1418-1430. [Water science and
technology : a journal of the International Association on Water Pollution
Research]
AB - This study was conducted to assess the levels of toxic metals like arsenic
(As), chromium (Cr), cadmium (Cd), and lead (Pb) in water and sediments of
the Pasur River in Bangladesh. The ranges of Cr, As, Cd, Pb in water were
25.76-77.39, 2.76-16.73, 0.42-2.98 and 12.69-42.67 &mu;g/L and in
sediments were 20.67-83.70, 3.15-19.97, 0.39-3.17 and 7.34-55.32 mg/kg.
The level of studied metals in water samples exceeded the safe limits of
drinking water, indicating that water from this river is not safe for
drinking and cooking. Certain indices, including pollution load index
(PLI) and contamination factor (Cif) were used to assess the ecological
risk. The PLI indicated progressive deterioration of sediments by the
studied metals. Potential ecological risks of metals in sediment indicated
low to considerable risk. However, the Cif values of Cd ranged from 0.86
to 8.37 revealed that the examined sediments were strongly impacted by Cd.
Considering the severity of potential ecological risk (PER) for single
metal (Eir), the descending order of contaminants was Cd > Pb > As
> Cr. According the results, some treatment scheme must formulate and
implement by the researchers and related management organizations to save
the Pasur River from metals contamination.
LA - eng
IS - 0273-1223 (Print)
PT - Journal Article
TA - Water Sci Technol
YR - 2018
DATE- 20180606
CITO- NLM
CS - England
FJT - Water science and technology : a journal of the International Association
on Water Pollution Research
STAT- In-Process
DOCNO- medline/29528329

457 - TOXLINE
TI - Genotoxicity of 11 heavy metals detected as food contaminants in two human
cell lines.
AU - Kopp B
AD - Toxicology of Contaminants Unit, French Agency for Food, Environmental and
Occupational Health &amp; Safety, Foug�res, France.
AU - Zalko D
AD - Toxalim, Universit� de Toulouse, INRA, INP-ENVT, INP-EI-Purpan, Universit� de
Toulouse 3 Paul Sabatier, Toulouse, France.
AU - Audebert M
AD - Toxalim, Universit� de Toulouse, INRA, INP-ENVT, INP-EI-Purpan, Universit� de
Toulouse 3 Paul Sabatier, Toulouse, France.
SO - Environ Mol Mutagen. 2018, Apr; 59(3):202-210. [Environmental and
molecular mutagenesis]
AB - Heavy metals, such as arsenic (As), antimony (Sb), barium (Ba), cadmium
(Cd), cobalt (Co), germanium (Ge), lead (Pb), nickel (Ni), tellurium (Te),
and vanadium (V) are widely distributed in the environment and in the food
chain. Human exposure to heavy metals through water and food has been
reported by different international agencies. Although some of these heavy
metals are essential elements for human growth and development, they may
also be toxic at low concentrations due to indirect mechanisms. In this
study, the genotoxic and cytotoxic properties of 15 different oxidation
statuses of 11 different heavy metals were investigated using
high-throughput screening (&gamma;H2AX assay) in two human cell lines
(HepG2 and LS-174T) representative of target organs (liver and colon) for
food contaminants. Base on their lowest observed adverse effect
concentration, the genotoxic potency of each heavy metal in each cell line
was ranked in decreasing order, NaAsO2 &thinsp; > &thinsp;CdCl2
&thinsp; > &thinsp;PbCl2 (only in LS-174T cells)&thinsp; > &thinsp;As2
O5 &thinsp; > &thinsp;SbCl3 &thinsp; > &thinsp;K2 TeO3
&thinsp; > &thinsp;As2 O3 . No significant genotoxicity was observed with
the other heavy metals tested. Cell viability data indicate that several
heavy metals (As, Cd, Co, Ni, Sb, and Te) induce cytotoxicity at high
concentrations, whereas an increase in the number of cells was observed
for lead concentrations > 100 &micro;M in both cell lines tested,
suggesting that lead stimulates cell growth. All these results highlight
the possible human health hazards associated with the presence of heavy
metals present in food. Environ. Mol. Mutagen. 59:202-210, 2018. &copy;
2017 Wiley Periodicals, Inc.
KW - H2AX
KW - genotoxicity
KW - heavy metals
KW - human cells
LA - eng
IS - 1098-2280 (Electronic)
PT - Journal Article
TA - Environ Mol Mutagen
YR - 2018
DATE- 20180315
CI - &copy; 2017 Wiley Periodicals, Inc.
CITO- NLM
CS - United States
FJT - Environmental and molecular mutagenesis
EDAT- 20171118
STAT- In-Data-Review
DOCNO- medline/29150881

458 - TOXLINE
TI - Poisoned Wine: Regulation, Chemical Analyses, and Spanish-French Trade in
the 1930s.
AU - Suay-Matallana I
AD - a Centro Interuniversit�rio de Hist�ria das Ci�ncias e da Tecnologia ,
Universidade Nova de Lisboa , Lisbon , Portugal.
AU - Guillem-Llobat X
AD - b Lopez Pi�ero Institute for the History of Medicine and Science ,
Universitat de Val�ncia , Valencia , Spain.
SO - Ambix. 2018, May; 65(2):99-121. [Ambix]
AB - This paper describes the resources, scientific spaces, and experts
involved in the study of a mass poisoning caused by the drinking of
arsenic-contaminated wine exported from Spain to France in 1932. Local and
international periodicals record the poisoning of 300 French sailors, and
stressed the commercial implications of the case. We discuss the reports
prepared by different experts (mainly physicians, agricultural engineers,
and customs chemists). Their work was not limited to preparing technical
publications or chemical analyses; they also actively defended the quality
of their local wine, and played a major role in the discussions regarding
the regulation of the international wine market in the 1930s, when new
standards regarding the analysis of wine were being considered. Curiously,
this well-publicised case of mass poisoning did not have any noticeable
consequences in the international regulation of wine. This absence of
subsequent regulatory action and the role of experts are central topics of
the paper.
LA - eng
IS - 1745-8234 (Electronic)
PT - Journal Article
TA - Ambix
YR - 2018
DATE- 20180606
CITO- NLM
CS - England
FJT - Ambix
EDAT- 20180416
STAT- In-Process
DOCNO- medline/29661062

459 - TOXLINE
TI - Metal concentrations in fillet and gill of parrotfish (Scarus ghobban)
from the Persian Gulf and implications for human health.
AU - Fakhri Y
AD - Department of Environmental Health Engineering, Student Research Committee,
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran,
Iran.
AU - Saha N
AD - School of Earth and Environmental Sciences, The University of Queensland,
Queensland, Australia.
AU - Miri A
AD - Department of Nutrition, School of Health, Zabol University of Medical
Sciences, Zabol, Iran.
AU - Baghaei M
AD - Department of Environmental Engineering-Water and Wastewater, Bandar Abbas
Branch, Islamic Azad University, Bandar Abbas, Iran. Electronic address:
pofm@gmail.com.
AU - Roomiani L
AD - Department of Fisheries, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.
Electronic address: L.roomiani@iau.ac.ir.
AU - Ghaderpoori M
AD - Department of Environmental Health Engineering, School of Health and
Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran.
AU - Taghavi M
AD - Department of Environmental Health Engineering, School of Public Health,
Gonabad University of Medical Sciences, Gonabad, Iran.
AU - Keramati H
AD - Department of Environmental Health Engineering, School of Public Health,
Semnan University of Medical Sciences, Semnan, Iran.
AU - Bahmani Z
AD - Department of Environmental Health Engineering, School of Public Health, Iran
University of Medical Sciences, Tehran, Iran.
AU - Moradi B
AD - Department of Health Public, Kermanshah University of Medical Sciences,
Kermanshah, Iran.
AU - Bay A
AD - Environmental Health Research Center, Golstan University of Medical Sciences,
Golstan, Iran. Electronic address: abotaleb_bay@yahoo.com.
AU - Pouya RH
AD - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar
Abbas, Iran. Electronic address: s.roxana.hosseini@gmail.com.
SO - Food Chem Toxicol. 2018, May 18; 118:348-354. [Food and chemical
toxicology : an international journal published for the British Industrial
Biological Research Association]
AB - Despite the benefits of seafood's consumption, the bioaccumulation of
metals in fish can endanger consumers' health. This study analyzed lead
(Pb), mercury (Hg), Arsenic (As), and Cadmium (Cd) concentrations in
fillet and gill of parrotfish (Scarus ghobban) using flame atomic
adsorption spectroscopy (FAAS). The potential non-carcinogenic and
carcinogenic health risks due to consumption of Scarus ghobban fillet were
assessed by estimating average target hazard quotient (THQ) and total
target hazard quotient (TTHQ) and Incremental Lifetime Cancer Risk cancer
risk (ILCR) of the analyzed metals. This study indicated that Cd, Pb, As
and Hg concentrations were significantly (p&#8239; < &#8239;0.05) lower
than Food and Agriculture Organization (FAO) and national standard limits.
The meal concentrations (&mu;g/kg dry weight) in both fillet and gill were
ranked as follows
Pb&#8239; > &#8239;Cd&#8239; > &#8239;As&#8239; > &#8239;Hg. THQ and
TTHQ were lower than 1 for adults and children, indicating that consumers
were not at considerable non-carcinogenic risk. However, ILCR value for As
was greater than 10-4, indicating that consumers are at carcinogenic risk.
Overall, this research highlighted that although the consumption of
parrotfish from the Persian Gulf does not pose non-carcinogenic health
risks, carcinogenic risks derived from toxic As can be detrimental for
local consumers.
KW - Food safety
KW - Health risk
KW - Heavy metals
KW - Parrotfish
KW - Persian gulf
KW - Seafood
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180518
STAT- Publisher
DOCNO- medline/29782897

460 - TOXLINE
TI - Carcinogenic and non-carcinogenic health risks of metal(oid)s in tap water
from Ilam city, Iran.
AU - Fakhri Y
AD - Department of Environmental Health Engineering, Student Research Committee,
School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran,
Iran.
AU - Saha N
AD - School of Earth and Environmental Sciences, The University of Queensland,
Queensland, Australia.
AU - Ghanbari S
AD - Health Products Safety Research Center, Qazvin University of Medical Science,
Qazvin, Iran.
AU - Rasouli M
AD - Department of Immunology, Shahid Beheshti University of Medical Sciences,
Tehran, Iran.
AU - Miri A
AD - Department of Nutrition, School of Health, Zabol University of Medical
Sciences, Zabol, Iran.
AU - Avazpour M
AD - Department of Environmental Health Engineering, School of Public Health, Ilam
University of Medical Sciences, Ilam, Iran. Electronic address:
mo_f_1859@yahoo.com.
AU - Rahimizadeh A
AD - Food Health Research Center, Hormozgan University of Medical Sciences, Bandar
Abbas, Iran. Electronic address: Rahimizadeh10@gmail.com.
AU - Riahi SM
AD - Department of Public Health, Faculty of Health, Birjand University of Medical
Sciences, Birjand, Iran.
AU - Ghaderpoori M
AD - Department of Environmental Health Engineering, School of Health and
Nutrition, Lorestan University of Medical Sciences, Khorramabad, Iran; Nutritional
Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
AU - Keramati H
AD - Department of Environmental Health Engineering, School of Public Health,
Semnan University of Medical Sciences, Semnan, Iran.
AU - Moradi B
AD - Department of Health Public, Kermanshah University of Medical Sciences,
Kermanshah, Iran.
AU - Amanidaz N
AD - Environmental Health Research Center, Golestan University of Medical
Sciences, Golestan, Iran.
AU - Mousavi Khaneghah A
AD - Department of Food Science, Faculty of Food Engineering, State University of
Campinas (UNICAMP), Rua Monteiro Lobato, 80. Caixa Postal: 6121, CEP: 13083-862
Campinas, Sao Paulo, Brazil.
SO - Food Chem Toxicol. 2018, Apr 20; 118:204-211. [Food and chemical
toxicology : an international journal published for the British Industrial
Biological Research Association]
AB - One of the most important pathways for exposure to metals is drinking
water ingestion. Chronic or acute exposure to metals can endanger the
health of the exposed population, and hence, estimation of human health
risks is crucial. In the current study for the first time, the
concentrations of Mercury (Hg), Arsenic (As), Zinc (Zn), Lead (Pb) and
Cobalt (Co) in 120 collected tap water samples (2015, July-November) from
Ilam city, Iran were investigated using flame atomic absorption
spectrophotometer. Also, the metal-induced carcinogenic and
non-carcinogenic risks for consumers exposed to tap drinking water were
calculated. The average (range) concentrations of Hg, Zn, As, Pb and Co
were defined as 0.40 &plusmn; 0.10 &mu;g/L
(ND-0.9 &mu;g/L), 5014 &plusmn; 5707 &mu;g/L
(2900.00-5668.33 &mu;g/L),
21.008 &plusmn; 2.876 &mu;g/L (3.5-62 &mu;g/L),
30.38 &plusmn; 5.56 &mu;g/L (6-87 &mu;g/L), and
11.34 &plusmn; 1.61 &mu;g/L (0.1-50 &mu;g/L),
respectively. Average concentrations of all examined metals were
significantly higher than WHO and national standard recommended limits.
The ranking order of metals concentrations in the tap drinking water was
Zn > Pb > As > Co > Hg.
Except for Hg and Co, at least one age group consumers were at
considerable non-carcinogenic risks induced by Zn, As and Pb [Target
Hazard Quotient (THQ > 1)]. The rank order of age groups
consumers based on THQ and Incremental lifetime cancer risk (ILCR) was
< 1 years > 1-9
years > 20 + years > 10-19 years. The
calculated ILCR for As in all age groups were higher than 10-3 value. All
age groups of consumers in Ilam city, especially infants ( < 1 years) and
children (1-10 years), are at considerable non-carcinogenic and
carcinogenesis risk.
KW - Calculated incremental lifetime cancer risk (ILCR)
KW - Iran
KW - Risk assessment
KW - Tap water
KW - Target Hazard Quotient (THQ)
KW - Trace metal(oid)s
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180420
STAT- Publisher
DOCNO- medline/29684495

461 - TOXLINE
TI - An assessment of polyurethane foam passive samplers for atmospheric metals
compared with active samplers.
AU - Li Q
AD - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of
Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China; School of
Environment, Henan Normal University, Key Laboratory for Yellow River and Huai
River Water Environment and Pollution Control, Ministry of Education, Henan Key
Laboratory for Environmental Pollution Control, Xinxiang, Henan 453007, China.
AU - Yang K
AD - School of Environment, Henan Normal University, Key Laboratory for Yellow
River and Huai River Water Environment and Pollution Control, Ministry of
Education, Henan Key Laboratory for Environmental Pollution Control, Xinxiang,
Henan 453007, China.
AU - Li J
AD - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of
Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. Electronic
address: junli@gig.ac.cn.
AU - Zeng X
AD - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of
Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
AU - Yu Z
AD - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of
Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
AU - Zhang G
AD - State Key Laboratory of Organic Geochemistry, Guangzhou Institute of
Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.
SO - Environ Pollut. 2018, May; 236:498-504. [Environmental pollution (Barking,
Essex : 1987)]
AB - In this study, we conducted an assessment of polyurethane foam (PUF)
passive sampling for metals combining active sampling. Remarkably, we
found that the metals collected in the passive samples differed greatly
from those collected in active samples. By composition, Cu and Ni
accounted for significantly higher proportions in passive samples than in
active samples, leading to significantly higher uptake rates of Cu and Ni.
In assessing seasonal variation, metals in passive samples had higher
concentrations in summer (excluding Heshan), which differed greatly from
the pattern of active samples (winter&#8239; > &#8239;summer), indicating
that the uptake rates of most metals were higher in summer than in winter.
Overall, due to the stable passive uptake rates, we considered that PUF
passive samplers can be applied to collect atmospheric metals.
Additionally, we created a snapshot of the metal pollution in the Pearl
River Delta using principal component analysis of PUF samples and their
source apportionment.
KW - Metals
KW - PUF passive sampling
KW - Seasonal variation
KW - Source analysis
KW - Uptake rate
RN - 9009-54-5
RN - CPD4NFA903
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180618
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
STAT- MEDLINE
DOCNO- medline/29425957

462 - TOXLINE
TI - Assessing potential release tendency of As, Mo and W in the tributary
sediments of the Three Gorges Reservoir, China.
AU - Gao L
AD - State Key Laboratory of Simulation and Regulation of Water Cycle in River
Basin, China Institute of Water Resources and Hydropower Research, Beijing 100038,
China; State Key Laboratory of Water Environment Simulation, School of Environment,
Beijing Normal University, Beijing 100875, China.
AU - Gao B
AD - State Key Laboratory of Simulation and Regulation of Water Cycle in River
Basin, China Institute of Water Resources and Hydropower Research, Beijing 100038,
China. Electronic address: gaosky34@hotmail.com.
AU - Peng W
AD - State Key Laboratory of Simulation and Regulation of Water Cycle in River
Basin, China Institute of Water Resources and Hydropower Research, Beijing 100038,
China.
AU - Xu D
AD - State Key Laboratory of Simulation and Regulation of Water Cycle in River
Basin, China Institute of Water Resources and Hydropower Research, Beijing 100038,
China.
AU - Yin S
AD - State Key Laboratory of Simulation and Regulation of Water Cycle in River
Basin, China Institute of Water Resources and Hydropower Research, Beijing 100038,
China.
SO - Ecotoxicol Environ Saf. 2018, Jan; 147:342-348. [Ecotoxicology and
environmental safety]
AB - As the largest man-made reservoir in China, the Three Gorges Reservoir
(TGR) has significant influence on national drinking water safety. The
geochemical behavior of trace elements at the sediment-water interface
(SWI) is still unknown. The mobilization characteristics of trace elements
(As, Mo and W)-determined by diffusive gradients in thin films (DGT)-were
studied to quantitatively calculate the release trends in the SWI in three
typical tributaries and the mainstream of the TGR in the summer. The
results showed that concentrations of DGT-labile As, Mo and W in the
overlying water and sediment cores showed significant variations in the
ranges of 0.05-50.90, 0.30-1.63 and 0.01-0.42&mu;gL-1, respectively. The
apparent net diffusive fluxes were significantly positive in most sampling
sites (77.8% for As, 88.8% for Mo and 66.6% for W), suggesting that the
sediment was the source of these three elements. It was noteworthy that
the maximum net diffusive fluxes of As and W were found in the upstream of
Meixi tributary, which may be attributed to anthropogenic activities. In
addition, As, Mo and W may be incorporated in Fe and Mn oxyhydroxides and
these three elements simultaneously remobilized with Fe and Mn.
KW - Diffusive fluxes
KW - Diffusive gradients in thin films (DGT)
KW - Sediment cores
KW - Three Gorges Reservoir
KW - Trace elements
RN - 81AH48963U
RN - N712M78A8G
RN - V9306CXO6G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20170914
STAT- MEDLINE
DOCNO- medline/28858707

463 - TOXLINE
TI - Incorporating Bioaccessibility into Human Health Risk Assessment of Heavy
Metals in Rice ( Oryza sativa L.): A Probabilistic-Based Analysis.
AU - Li T
AD - Key Laboratory of Integrated Regulation and Resource Development on Shallow
Lake of Ministry of Education, College of Environment , Hohai University , Nanjing
210098 , Jiangsu Province , P.R. China.
AU - Song Y
AD - Key Laboratory of Integrated Regulation and Resource Development on Shallow
Lake of Ministry of Education, College of Environment , Hohai University , Nanjing
210098 , Jiangsu Province , P.R. China.
AU - Yuan X
AD - Key Laboratory of Integrated Regulation and Resource Development on Shallow
Lake of Ministry of Education, College of Environment , Hohai University , Nanjing
210098 , Jiangsu Province , P.R. China.
AU - Li J
AD - Key Laboratory of Integrated Regulation and Resource Development on Shallow
Lake of Ministry of Education, College of Environment , Hohai University , Nanjing
210098 , Jiangsu Province , P.R. China.
AU - Ji J
AD - Key Laboratory of Surficial Geochemistry, Ministry of Education, School of
Earth Sciences and Engineering , Nanjing University , Nanjing 210046 , Jiangsu
Province , P.R. China.
AU - Fu X
AD - Shandong Provincial Key Laboratory of Applied Microbiology, Ecology Institute
, Qilu University of Technology (Shandong Academy of Science) , Jinan 250014 ,
Shandong Province , P.R. China.
AU - Zhang Q
AD - Shandong Provincial Key Laboratory of Applied Microbiology, Ecology Institute
, Qilu University of Technology (Shandong Academy of Science) , Jinan 250014 ,
Shandong Province , P.R. China.
AU - Guo S
AD - Shandong Provincial Key Laboratory of Applied Microbiology, Ecology Institute
, Qilu University of Technology (Shandong Academy of Science) , Jinan 250014 ,
Shandong Province , P.R. China.
SO - J Agric Food Chem. 2018, Jun 06; 66(22):5683-5690. [Journal of
agricultural and food chemistry]
AB - A systematic investigation into total and bioaccessible heavy metal
concentrations in rice grains harvested from heavy metal-contaminated
regions was carried out to assess the potential health risk to local
residents. Arsenic, Cr, Cu, Pb, and Zn concentrations were within
acceptable levels while Cd and Ni concentrations appeared to be much
higher than in other studies. The bioaccessibity of As, Cd, and Ni was
high ( > 25%) and could be well predicted from their total
concentrations. The noncarcinogenic risk posed by As and Cd was
significant. The carcinogenic risk posed by all bioaccessible heavy metals
at the fifth percentile was 10-fold higher than the acceptable level, and
Cd and Ni were the major contributors. The contribution of each metal to
the combined carcinogenic risk indicates that taking pertinent precautions
for different types of cancer, aimed at individuals with different levels
of exposure to heavy metals, will greatly reduce morbidity and mortality
rates.
KW - Monte Carlo simulation
KW - bioaccessibility
KW - health risk assessment
KW - heavy metals
KW - rice
LA - eng
IS - 1520-5118 (Electronic)
PT - Journal Article
TA - J Agric Food Chem
YR - 2018
DATE- 20180606
CITO- NLM
CS - United States
FJT - Journal of agricultural and food chemistry
EDAT- 20180522
STAT- In-Process
DOCNO- medline/29749235

464 - TOXLINE
TI - Iron and sulfur cycling in acid sulfate soil wetlands under dynamic redox
conditions: A review.
AU - Karimian N
AD - Southern Cross GeoScience, Southern Cross University, Lismore, NSW, 2480,
Australia. Electronic address: niloofar.karimian@scu.edu.au.
AU - Johnston SG
AD - Southern Cross GeoScience, Southern Cross University, Lismore, NSW, 2480,
Australia.
AU - Burton ED
AD - Southern Cross GeoScience, Southern Cross University, Lismore, NSW, 2480,
Australia.
SO - Chemosphere. 2018, Apr; 197:803-816. [Chemosphere]
AB - Acid sulfate soils (ASS) contain substantial quantities of iron sulfide
minerals or the oxidation reaction products of these sulfidic minerals.
Transformation of iron (Fe) and sulfur (S) bearing minerals is an
important process in ASS wetlands with fluctuating redox conditions. A
range of potentially toxic metals and metalloids can either be adsorbed on
or incorporated into the structure of Fe and S bearing minerals.
Therefore, transformation of these minerals as affected by dynamic redox
conditions may regulate the mobility and bioavailability of associated
metals/metalloids. Better understanding of the interaction between Fe/S
biogeochemistry and trace metal/metalloid mobility under fluctuating redox
conditions is important for assessing contaminant risk to the environment.
This review paper provides an overview of current knowledge regarding
cycling of Fe, S and selected trace metal/metalloids in ASS wetlands under
fluctuating redox conditions and outlines future research challenges and
directions on this subject.
KW - Acid sulfate soils
KW - Antimony
KW - Arsenic
KW - Dynamic redox
KW - Iron
KW - Sulfur
RN - 70FD1KFU70
RN - E1UOL152H7
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
PT - Review
TA - Chemosphere
YR - 2018
DATE- 20180613
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
STAT- MEDLINE
DOCNO- medline/29407844

465 - TOXLINE
TI - River sediment quality assessment using sediment quality indices for the
Sydney basin, Australia affected by coal and coal seam gas mining.
AU - Ali AE
AD - Department of Environmental Sciences, Faculty of Science and Engineering,
Macquarie University NSW 2109, Australia.
AU - Strezov V
AD - Department of Environmental Sciences, Faculty of Science and Engineering,
Macquarie University NSW 2109, Australia. Electronic address:
vladimir.strezov@mq.edu.au.
AU - Davies PJ
AD - Department of Environmental Sciences, Faculty of Science and Engineering,
Macquarie University NSW 2109, Australia.
AU - Wright I
AD - School of Science and Health, University of Western Sydney, Locked Bag 1797,
South Penrith, NSW, Australia.
SO - Sci Total Environ. 2018, Mar; 616-617:695-702. [The Science of the total
environment]
AB - Coal mining activities in the Sydney basin have been historically
associated with significant environmental impacts. The region is facing
more recent coal seam gas extraction activities and the synergetic
environmental impacts of the new mining activities are still largely
unknown. The aim of this study was to provide environmental assessment of
river sediments comparing upstream to downstream areas relative to
industrial-discharge sites associated with coal and coal-seam-gas
extraction within the Sydney basin. Various contaminants were measured to
determine the sediment quality according to the Australian and New Zealand
Environment and Conservation Council (ANZECC) guidelines. Arsenic, nickel
and zinc were the main sediment contaminants in downstream samples
exceeding the ANZECC guidelines. Degree of contamination (Cd),
geoaccumulation index (Igeo), enrichment factor (EF), pollution load index
(PLI) and sediment environmental toxicity quotients' increment in
downstream sediment were estimated for the studied areas. Toxicology
indices of metals present in the sediments near industrial discharge sites
were used as an additional tool to compare the level of environmental
effects with their increment. The study revealed that the sediments from
coal mining sites were highly affected by increased concentrations of
manganese, zinc, cobalt, nickel and barium. The sediments associated with
coal mining activities were found to be substantially more affected than
the sediments near coal seam gas production sites, mainly attributed to
the different wastewater discharge licencing requirements. The approach
applied in this study can be used as an additional model to assess the
contribution of industrial and mining activities on aquatic environments.
KW - Coal mine
KW - Environmental effect
KW - Environmental toxicity quotient (ETQ)
KW - Mean effective range median quotient (ERMQ)
KW - Produced water
KW - Sediment quality guidelines value (SQGV)
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180309
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20171027
STAT- PubMed-not-MEDLINE
DOCNO- medline/29111250

466 - TOXLINE
TI - Geospatial distribution of metal(loid)s and human health risk assessment
due to intake of contaminated groundwater around an industrial hub of
northern India.
AU - Kashyap R
AD - High Altitude Biology Division, CSIR-Institute of Himalayan Bioresource
Technology, Palampur, Himachal Pradesh, 176 061, India. rachit198@gmail.com.
AU - Verma KS
AD - Department of Environmental Science, Dr Yashwant Singh Parmar University of
Horticulture, and Forestry, Nauni, Solan, Himachal Pradesh, 173 230, India.
AU - Uniyal SK
AD - High Altitude Biology Division, CSIR-Institute of Himalayan Bioresource
Technology, Palampur, Himachal Pradesh, 176 061, India.
AU - Bhardwaj SK
AD - Department of Environmental Science, Dr Yashwant Singh Parmar University of
Horticulture, and Forestry, Nauni, Solan, Himachal Pradesh, 173 230, India.
SO - Environ Monit Assess. 2018, Feb 12; 190(3):136. [Environmental monitoring
and assessment]
AB - The study focused on analyzing concentrations of metal(loid)s, their
geospatial distribution in groundwater around an industrial hub of
northern India. Human health risk posed due to the intake of contaminated
groundwater was also evaluated. For this, 240 samples were assayed using
inductively coupled plasma emission spectrophotometer. For risk
assessment, the methodology proposed by US Environmental Protection Agency
was adopted. Geometric mean of Al, As, Mo, Cd, Co, Cr, Fe, Mn, Ni, Pb, Se,
and Zn was 193.13, 27.35, 4.22, 2.85, 92.81, 14.97, 271.78, 25.76, 54.75,
19.50, 16.94, and 1830.27 &mu;g/l, respectively. Levels of Al (84%),
As (63%), Ni (63%), Pb (49%), and Se (41%) exceeded the Bureau of Indian
Standards (BIS). Principal component analysis is accounted for
~&thinsp;88% of the total variance and reflected pollution loads of Al,
As, Mo, Cr, Fe, Se, and Pb in the groundwater. Based on it, four sources
of metal(loid)s, namely geogenic (34.55%), mixed (industrial and
agricultural, 26.76%), waste dumping (15.31%), and industrial (11.25%)
were identified. Semi-variogram mapping model demonstrated significant
geospatial variations of the metal(loid)s. Hazard index (HI) suggested
potential non-carcinogenic risks to the inhabitants due to As, Al, Ni, Se,
and Pb, which were the largest contributors. Based on maximum
concentrations of metal(loid)s, HI for child and adult was above unity.
Arsenic was identified as the most hazardous pollutant that may have
chronic carcinogenic health implications. At western side of study area,
carcinogenic health risks exceeded critical threshold of
1&thinsp;&times;&thinsp;10-4, indicating that As posed health risks to
residents by intake of groundwater.
KW - Groundwater
KW - Health risk
KW - Industrial hub
KW - Metal(loid)s
KW - Northern India
RN - N712M78A8G
LA - eng
IS - 1573-2959 (Electronic)
PT - Journal Article
TA - Environ Monit Assess
YR - 2018
DATE- 20180515
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Environmental monitoring and assessment
EDAT- 20180212
STAT- MEDLINE
CM - Cites: J Toxicol Environ Health B Crit Rev. 2007;10 Suppl 1:1-269 (medline
/18085482)
CM - Cites: ScientificWorldJournal. 2014;2014:304524 (medline /25374935)
CM - Cites: Environ Monit Assess. 2015 Jul;187(7):397 (medline /26038318)
CM - Cites: Int J Environ Health Res. 2014;24(5):429-49 (medline /24266701)
CM - Cites: J Hazard Mater. 2011 May 30;189(3):640-6 (medline /21324586)
CM - Cites: Chemosphere. 2017 Jul;179:167-178 (medline /28365502)
CM - Cites: Bull Environ Contam Toxicol. 2016 Nov;97(5):737-742 (medline
/27638703)
CM - Cites: Water Res. 2006 Feb;40(4):753-67 (medline /16448684)
CM - Cites: J Hazard Mater. 2014 Jan 30;265:305-14 (medline /24184125)
CM - Cites: Int J Environ Res Public Health. 2005 Aug;2(2):214-8 (medline
/16705820)
CM - Cites: Health Phys. 1995 Apr;68(4):509-22 (medline /7883563)
CM - Cites: Environ Monit Assess. 2003 Nov;89(1):43-67 (medline /14609274)
CM - Cites: J Environ Manage. 2005 Apr;75(2):129-32 (medline /15763155)
CM - Cites: Chemosphere. 2007 Jan;66(3):505-13 (medline /16844191)
CM - Cites: Environ Monit Assess. 2015 Mar;187(3):63 (medline /25647791)
CM - Cites: Environ Monit Assess. 2010 Jun;165(1-4):103-12 (medline /19418235)
DOCNO- medline/29435679

467 - TOXLINE
TI - Air-Filled Porosity as a Key to Reducing Dissolved Arsenic and Cadmium
Concentrations in Paddy Soils.
AU - Nakamura K
AU - Katou H
AU - Suzuki K
AU - Honma T
SO - J Environ Qual. 2018, May; 47(3):496-503. [Journal of environmental
quality]
AB - Simultaneous suppression of rice ( L.) uptake of As and Cd is challenging
because these toxic elements are immobilized under contrasting redox
conditions. Given the notion that oxygen diffusion governs redox
conditions in temporarily drained paddy soil, we assume that the key to
simultaneous suppression of dissolved As and Cd concentrations is
air-filled porosity (AFP) of soil. The objectives of this study were to
reveal relationships between AFP and dissolved As and Cd concentrations in
paddy soils and to identify the optimum water management, in terms of AFP,
for simultaneous reduction of As and Cd. Dissolved As and Cd
concentrations were determined in soil cores collected at different depths
and times during rice growing seasons. Dissolved As concentrations were
appreciable ( > 3 &micro;g L) only when AFP was below a threshold value
of 0.04 to 0.10 m m, suggesting that dissolved As was rapidly immobilized
once AFP exceeded the threshold value on drainage. Dissolved Cd
concentrations were roughly proportional to AFP, with higher
concentrations associated with lower soil pH. Although dissolved As
concentrations tended to be low in soil samples with high dissolved Cd
concentrations and vice versa, both concentrations were low when AFP was
slightly above the threshold value for As immobilization. The results
suggest that dissolved As and Cd can be simultaneously kept at low levels
by appropriate water management practices that produce AFP slightly above
the threshold value for As immobilization.
LA - eng
IS - 0047-2425 (Print)
PT - Journal Article
TA - J Environ Qual
YR - 2018
DATE- 20180604
CI - Copyright &copy; by the American Society of Agronomy, Crop Science Society
of America, and Soil Science Society of America, Inc.
CITO- NLM
CS - United States
FJT - Journal of environmental quality
STAT- In-Data-Review
DOCNO- medline/29864174

468 - TOXLINE
TI - Dietary Intakes of Minerals, Essential and Toxic Trace Elements for Adults
from Eragrostis tef L.: A Nutritional Assessment.
AU - Koubov� E
AD - Department of Food Analysis and Chemistry, Tomas Bata University in Zl�n,
N�m&#283;st� T.G. Masaryka 5555, 760 01 Zl�n, Czech Republic. kotaskova@ft.utb.cz.
AU - Sumczynski D
AD - Department of Food Analysis and Chemistry, Tomas Bata University in Zl�n,
N�m&#283;st� T.G. Masaryka 5555, 760 01 Zl�n, Czech Republic. sumczynski@utb.cz.
AU - &Scaron;enk�rov� L
AD - Department of Environmental Protection Engineering, Tomas Bata University in
Zl�n, N�m&#283;st� T.G. Masaryka 5555, 760 01 Zl�n, Czech Republic.
lveverkova@ft.utb.cz.
AU - Orsavov� J
AD - Language Centre, Tomas Bata University in Zl�n, &Scaron;tef�nikova 5670, 760
01 Zl�n, Czech Republic. orsavova@fhs.utb.cz.
AU - Fi&scaron;era M
AD - Department of Food Analysis and Chemistry, Tomas Bata University in Zl�n,
N�m&#283;st� T.G. Masaryka 5555, 760 01 Zl�n, Czech Republic. fisera@utb.cz.
SO - Nutrients. 2018, Apr 12. [Nutrients]
AB - This study analysed the contents of thirty-six mineral and trace elements
in teff (Eragrostis tef L.) grains. What is more, dietary intakes were
calculated. Inductively coupled plasma mass spectrometry (ICP-MS) was used
to assess mineral and trace element contents. Consequently, the
appropriate Recommended Dietary Allowance (RDA) or adequate intake (AI),
and provisional tolerable weekly intake (PTWI) or provisional tolerable
monthly intake (PTMI) values for adults were determined according to the
Food and Agriculture Organization/World Health Organization (FAO/WHO) and
Institute of Medicine (IOM) regulations. Teff is a significant contributor
to RDAs and AIs for females in the following order: Mn > Cu > Zn
&ge; Mg > Fe &ge; P and Ca. For males, teff contributes in the order,
Mn > Cu > Fe > Zn &ge; P &ge; Mg > and Ca. The concentration
of arsenic (65.9 &micro;g/kg) in brown teff originating in Bolivia
exceeded the average acceptable value set by Reg. No. 1881 of 6-50
&micro;g/kg in cereals consumed in the EU. The PTWIs or PTMIs for Al, Cd,
Sn and Hg were all under 7%, which is below the limits of toxic element
intake related to the body weight of 65 kg for adult females and 80 kg for
males, set by the FAO/WHO. Teff grains can be recommended as a valuable
and safe source of minerals and trace elements.
COI - The authors declare no conflict of interest.
KW - Eragrostis tef
KW - ICP-MS
KW - dietary intakes
KW - essential trace elements
KW - minerals
KW - toxic trace elements
LA - eng
IS - 2072-6643 (Electronic)
PT - Journal Article
TA - Nutrients
YR - 2018
DATE- 20180516
CITO- NLM
CS - Switzerland
FJT - Nutrients
EDAT- 20180412
STAT- In-Process
CM - Cites: Environ Health Prev Med. 2013 May;18(3):230-6 (medline /23108579)
CM - Cites: Food Chem. 2012 Jun 1;132(3):1502-1513 (medline /29243642)
CM - Cites: Food Chem Toxicol. 2013 Dec;62:856-8 (medline /24416776)
CM - Cites: Int J Food Sci Nutr. 2013 Dec;64(8):915-20 (medline /23777527)
CM - Cites: Chemosphere. 2010 Jun;80(1):28-34 (medline /20413142)
CM - Cites: Appl Radiat Isot. 2008 Aug;66(8):1067-72 (medline /18424050)
CM - Cites: Food Chem. 2011 Jun 15;126(4):1787-99 (medline /25213958)
CM - Cites: J Alzheimers Dis. 2010;20(1):17-30 (medline /20378957)
CM - Cites: Sci Total Environ. 2004 Jan 5;318(1-3):223-44 (medline /14654287)
DOCNO- medline/29649158

469 - TOXLINE
TI - Detection and quantitative determination of heavy metals in electronic
cigarette refill liquids using Total Reflection X-ray Fluorescence
Spectrometry.
AU - Kamilari E
AD - Laboratory of Pharmaceutical Analysis, Department of Pharmacy, University of
Patras, Greece.
AU - Farsalinos K
AD - Laboratory of Molecular Biology and Immunology, Department of Pharmacy,
University of Patras, Greece; Onassis Cardiac Surgery Center, Athens, Greece.
AU - Poulas K
AD - Laboratory of Molecular Biology and Immunology, Department of Pharmacy,
University of Patras, Greece.
AU - Kontoyannis CG
AD - Laboratory of Pharmaceutical Analysis, Department of Pharmacy, University of
Patras, Greece; Institute of Chemical Engineering Sciences/Foundation for Research
and Technology Hellas, Patras, Greece.
AU - Orkoula MG
AD - Laboratory of Pharmaceutical Analysis, Department of Pharmacy, University of
Patras, Greece. Electronic address: malbie@upatras.gr.
SO - Food Chem Toxicol. 2018, Jun; 116(Pt B):233-237. [Food and chemical
toxicology : an international journal published for the British Industrial
Biological Research Association]
AB - Electronic cigarettes are considered healthier alternatives to
conventional cigarettes containing tobacco. They produce vapor through
heating of the refill liquids (e-liquids) which consist of propylene
glycol, vegetable glycerin, nicotine (in various concentrations), water
and flavoring agents. Heavy metals may enter the refill liquid during the
production, posing a risk for consumer's health due to their toxicity. The
objective of the present study was the development of a methodology for
the detection and quantitative analysis of cadmium (Cd), lead (Pb), nickel
(Ni), copper (Cu), arsenic (As) and chromium (Cr), employing Total
Reflection X-Ray Fluorescence Spectroscopy (TXRF) as an alternative
technique to ICP-MS or ICP-OES commonly used for this type of analysis.
TXRF was chosen due to its advantages, which include short analysis time,
promptness, simultaneous multi-element analysis capability and minimum
sample preparation, low purchase and operational cost. The proposed
methodology was applied to a large number of electronic cigarette liquids
commercially available, as well as their constituents, in order to
evaluate their safety. TXRF may be a valuable tool for probing heavy
metals in electronic cigarette refill liquids to serve for the protection
of human health.
KW - Electronic cigarette
KW - Heavy metals
KW - Refill liquid
KW - Total Reflection X-ray Fluorescence Spectroscopy
LA - eng
IS - 1873-6351 (Electronic)
PT - Journal Article
TA - Food Chem Toxicol
YR - 2018
DATE- 20180516
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Food and chemical toxicology : an international journal published for the
British Industrial Biological Research Association
EDAT- 20180418
STAT- In-Process
DOCNO- medline/29679608

470 - TOXLINE
TI - Serum Concentrations of 15 Elements Among Helicobacter Pylori-Infected
Residents from Lujiang County with High Gastric Cancer Risk in Eastern
China.
AU - Hu A
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Li L
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Hu C
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Zhang D
AD - Department of Gastroenterology, Lujiang County People's Hospital, Hefei,
Anhui Province, 231500, China.
AU - Wang C
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Jiang Y
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Zhang M
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Liang C
AD - Department of Hygiene Analysis and Detection, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Chen W
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Bo Q
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China.
AU - Zhao Q
AD - Department of Nutrition and Food Hygiene, School of Public Health, Anhui
Medical University, Hefei, Anhui Province, 230032, China. qihong@ahmu.edu.cn.
SO - Biol Trace Elem Res. 2018, Mar 03. [Biological trace element research]
AB - Helicobacter pylori (H. pylori) infection can interfere with the
absorption of most elements, and the variations of some element levels are
related to the incidence of gastric cancer. However, there have been
conflicting results concerning the influence of H. pylori infection on
serum element levels. The present study aimed to compare the serum element
concentrations of H. pylori-infected local residents with uninfected
residents from Lujiang County with high gastric cancer risk in Eastern
China. We used data and serum samples from the H. pylori screening-survey
program which was a cross-sectional study. We took 155 samples randomly
from the screening survey, identified 74 H. pylori-positive residents and
81 H. pylori-negative residents by a serological test. The serum
concentrations of 15 elements (calcium, magnesium, iron, zinc, selenium,
copper, molybdenum, chromium, cobalt, nickel, lead, cadmium, mercury,
arsenic, and aluminum) were determined using inductively coupled plasma
mass spectrometry. Serum cobalt was found at higher levels in the H.
pylori-infected residents than the H. pylori-uninfected residents (0.246
vs 0.205 &mu;g/L, P&thinsp;=&thinsp;0.022), but no statistically
significant differences in the serum levels of other elements were found.
This is the first study to report the serum concentrations of 15 elements
and their relationships with the infection status of H. pylori among local
residents from Lujiang County with high gastric cancer risk. Although the
International Agency for Research on Cancer has classified cobalt and
other soluble cobalt salts as possibly carcinogenic to human beings, our
results may provide a clue to the relationships between cobalt, H. pylori,
and gastric cancer.
KW - Cobalt
KW - Elements
KW - Gastric cancer
KW - Helicobacter pylori
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180304
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180303
STAT- Publisher
DOCNO- medline/29502251

471 - TOXLINE
TI - Phosgene oxime: Injury and associated mechanisms compared to vesicating
agents sulfur mustard and lewisite.
AU - Goswami DG
AD - Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and
Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO
80045, USA.
AU - Agarwal R
AD - Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and
Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO
80045, USA.
AU - Tewari-Singh N
AD - Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and
Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO
80045, USA. Electronic address: neera.tewari-singh@ucdenver.edu.
SO - Toxicol Lett. 2018, Sep 01; 293:112-119. [Toxicology letters]
AB - Phosgene Oxime (CX, Cl2CNOH), a halogenated oxime, is a potent chemical
weapon that causes immediate acute injury and systemic effects. CX,
grouped together with vesicating agents, is an urticant or nettle agent
with highly volatile, reactive, corrosive, and irritating vapor, and has
considerably different chemical properties and toxicity compared to other
vesicants. CX is absorbed quickly through clothing with faster cutaneous
penetration compared to other vesicating agents causing instantaneous and
severe damage. For this reason, it could be produced as a weaponized
mixture with other chemical warfare agents to enhance their deleterious
effects. The immediate devastating effects of CX and easy synthesis makes
it a dangerous chemical with both military and terrorist potentials.
Although CX is the most potent vesicating agent, it is one of the least
studied chemical warfare agents and the pathophysiology as well as long
term effects are largely unknown. CX exposure results in immediate pain
and inflammation, and it mainly affects skin, eye and respiratory system.
There are no antidotes available against CX-induced injury and the
treatment is only supportive. This review summarizes existing knowledge
regarding exposure, toxicity and the probable underlying mechanisms of CX
compared to other important vesicants' exposure.
KW - Nettle agent
KW - Phosgene oxime
KW - Skin damage
KW - Systemic toxicity
KW - Urticaria
KW - Vesicating agent
RN - 0N54LGU5WS
RN - 117K140075
RN - T8KEC9FH9P
LA - eng
IS - 1879-3169 (Electronic)
PT - Journal Article
PT - Review
TA - Toxicol Lett
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Toxicology letters
EDAT- 20171112
STAT- MEDLINE
CM - Cites: Curr Eye Res. 2001 Jan;22(1):42-53 (medline /11402378)
CM - Cites: Fundam Clin Pharmacol. 2005 Jun;19(3):297-315 (medline /15910653)
CM - Cites: Clin Exp Ophthalmol. 2006 May-Jun;34(4):342-6 (medline /16764654)
CM - Cites: Biochem Pharmacol. 2016 Jan 15;100:1-11 (medline /26476351)
CM - Cites: Crit Care Clin. 2005 Oct;21(4):707-18, vi (medline /16168310)
CM - Cites: Clin Rev Allergy Immunol. 2006 Feb;30(1):3-11 (medline /16461989)
CM - Cites: Environ Sci Technol. 2006 Jul 1;40(13):4219-25 (medline /16856738)
CM - Cites: Toxicology. 2011 Apr 11;282(3):129-38 (medline /21295104)
CM - Cites: Am J Respir Cell Mol Biol. 2011 Aug;45(2):323-31 (medline
/21642592)
CM - Cites: Toxicol Sci. 2009 Mar;108(1):194-206 (medline /19075041)
CM - Cites: Emerg Health Threats J. 2008;1:e7 (medline /22460216)
CM - Cites: J Pharmacol Exp Ther. 2011 Feb;336(2):450-9 (medline /20974699)
CM - Cites: Curr Eye Res. 2014 May;39(5):439-50 (medline /24215293)
CM - Cites: Toxicol Appl Pharmacol. 2009 Dec 1;241(2):154-62 (medline
/19682477)
CM - Cites: Toxicol Lett. 2011 Sep 10;205(3):293-301 (medline /21722719)
CM - Cites: Inhal Toxicol. 2007 May;19(5):451-6 (medline /17365048)
CM - Cites: Toxicol Pathol. 2003 Mar-Apr;31(2):185-90 (medline /12696578)
CM - Cites: Toxicol Appl Pharmacol. 2013 Nov 1;272(3):879-87 (medline
/23954561)
CM - Cites: Toxicol Appl Pharmacol. 2017 Feb 15;317:25-32 (medline /28087322)
CM - Cites: J Res Med Sci. 2013 Oct;18(10):855-9 (medline /24497855)
CM - Cites: Arch Toxicol. 2005 Nov;79(11):660-70 (medline /16001271)
CM - Cites: Toxicology. 2005 Oct 30;214(3):198-209 (medline /16084004)
CM - Cites: Sci Rep. 2016 Oct 11;6:34865 (medline /27725709)
CM - Cites: Cutan Ocul Toxicol. 2007;26(2):73-81 (medline /17612976)
CM - Cites: Exp Mol Pathol. 2011 Oct;91(2):515-27 (medline /21672537)
CM - Cites: Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L82-92
(medline /21964405)
CM - Cites: Chem Biol Interact. 2013 Dec 5;206(3):496-504 (medline /23810508)
CM - Cites: J Burns Wounds. 2007 Oct 30;7:e7 (medline /18091984)
CM - Cites: Toxicol Appl Pharmacol. 2016 Aug 15;305:1-11 (medline /27212445)
CM - Cites: J Appl Toxicol. 1998 Nov-Dec;18(6):409-20 (medline /9840748)
CM - Cites: Interdiscip Toxicol. 2008 Jun;1(1):22-6 (medline /21218101)
CM - Cites: Cutan Ocul Toxicol. 2013 Oct;32(4):304-24 (medline /23590683)
CM - Cites: J Clin Invest. 1946 Jul;25(4):541-8 (medline /21001628)
CM - Cites: Toxicol Sci. 2006 Apr;90(2):549-57 (medline /16141436)
CM - Cites: Ann N Y Acad Sci. 2010 Aug;1203:92-100 (medline /20716289)
CM - Cites: Toxicology. 2009 Sep 1;263(1):12-9 (medline /19651324)
CM - Cites: Ann N Y Acad Sci. 2016 Jun;1374(1):193-201 (medline /27327041)
CM - Cites: Urol J. 2013 Spring;10(2):837-46 (medline /23801464)
CM - Cites: J Appl Toxicol. 2000 Dec;20 Suppl 1:S173-5 (medline /11428631)
CM - Cites: Cornea. 2013 Apr;32(4):e44-50 (medline /23132440)
CM - Cites: Ann Pharmacother. 2008 Feb;42(2):237-46 (medline /18212254)
CM - Cites: Ann N Y Acad Sci. 2016 Jun;1374(1):184-92 (medline /27326543)
CM - Cites: Dermatol Res Pract. 2014;2014:674709 (medline /25120565)
CM - Cites: Toxicology. 2014 Jun 5;320:25-33 (medline /24631667)
CM - Cites: Basic Clin Pharmacol Toxicol. 2006 Oct;99(4):273-82 (medline
/17040211)
CM - Cites: Ann N Y Acad Sci. 2016 Aug;1378(1):143-157 (medline /27636894)
CM - Cites: Int J Dermatol. 2006 Sep;45(9):1025-31 (medline /16961503)
CM - Cites: Toxicology. 2009 Mar 29;257(3):105-12 (medline /19111594)
CM - Cites: Pathol Res Pract. 2006;202(10):739-44 (medline /16887283)
CM - Cites: Toxicol Lett. 2016 Feb 26;244:56-71 (medline /26383629)
CM - Cites: Skin Res Technol. 2010 Feb;16(1):114-24 (medline /20384890)
CM - Cites: Toxicol Ind Health. 2007 May;23(4):209-21 (medline /18429381)
CM - Cites: Inhal Toxicol. 2005 Oct;17(11):587-92 (medline /16033754)
CM - Cites: J Dermatol Sci. 1997 Feb;14(2):126-35 (medline /9039976)
CM - Cites: Toxicology. 2009 Sep 1;263(1):70-3 (medline /18852011)
CM - Cites: Toxicol Appl Pharmacol. 2012 Oct 1;264(1):23-31 (medline /22841772)
CM - Cites: Crit Rev Toxicol. 2011 May;41(5):384-403 (medline /21329486)
CM - Cites: Am J Ophthalmol. 1946 Oct;29:1215-27 (medline /21000610)
CM - Cites: Br J Pharmacol. 2004 Mar;141(5):795-802 (medline /14769780)
CM - Cites: J Biochem Mol Toxicol. 2002;16(6):263-72 (medline /12481301)
CM - Cites: Am J Pathol. 2016 Oct;186(10 ):2637-49 (medline /27528504)
CM - Cites: Ann N Y Acad Sci. 2016 Aug;1378(1):87-95 (medline /27384912)
CM - Cites: J Appl Toxicol. 2010 Oct;30(7):627-43 (medline /20836142)
CM - Cites: Invest Ophthalmol Vis Sci. 2005 May;46(5):1640-6 (medline
/15851563)
CM - Cites: Toxicol Lett. 2015 Jan 5;232(1):68-78 (medline /25275893)
CM - Cites: Pharmacol Rev. 1996 Jun;48(2):289-326 (medline /8804107)
CM - Cites: Toxicology. 2009 Sep 1;263(1):59-69 (medline /19061933)
CM - Cites: Invest Ophthalmol Vis Sci. 2003 Jul;44(7):2966-72 (medline
/12824239)
CM - Cites: Cutan Ocul Toxicol. 2013 Jun;32(2):115-23 (medline /23106194)
CM - Cites: J Cutan Pathol. 1995 Jun;22(3):260-8 (medline /7593821)
CM - Cites: Free Radic Biol Med. 2011 Dec 15;51(12):2272-80 (medline /21920433)
CM - Cites: Toxicol Sci. 2010 Mar;114(1):5-19 (medline /19833738)
CM - Cites: PLoS One. 2013 Jun 24;8(6):e67557 (medline /23826320)
CM - Cites: Rev Environ Contam Toxicol. 1989;110:75-115 (medline /2692088)
CM - Cites: Toxicology. 2006 May 1;222(1-2):8-16 (medline /16488528)
CM - Cites: Eplasty. 2008 Jun 10;8:e32 (medline /18615149)
CM - Cites: Toxicology. 2001 Jun 21;163(2-3):137-44 (medline /11516523)
CM - Cites: J Appl Toxicol. 2006 May-Jun;26(3):239-46 (medline /16489579)
CM - Cites: Clin Exp Dermatol. 2006 Jan;31(1):1-5 (medline /16309468)
CM - Cites: Chron Respir Dis. 2008;5(2):95-100 (medline /18539723)
CM - Cites: Cornea. 2012 Mar;31(3):280-90 (medline /22316652)
CM - Cites: Toxicol Appl Pharmacol. 2013 Oct 15;272(2):291-8 (medline
/23806213)
CM - Cites: Exp Toxicol Pathol. 2015 Feb;67(2):161-70 (medline /25481215)
CM - Cites: Cutan Ocul Toxicol. 2010 Dec;29(4):269-77 (medline /20868209)
CM - Cites: Environ Health Perspect. 1992 Nov;98 :259-80 (medline /1486858)
CM - Cites: Exp Toxicol Pathol. 2014 Mar;66(2-3):129-38 (medline /24373750)
CM - Cites: Chem Res Toxicol. 2010 Jun 21;23(6):1034-44 (medline /20469912)
CM - Cites: Cornea. 2016 Feb;35(2):257-66 (medline /26555588)
CM - Cites: Toxicol Appl Pharmacol. 2010 Jun 15;245(3):352-60 (medline
/20382172)
CM - Cites: J Pharm Bioallied Sci. 2010 Jul;2(3):166-78 (medline /21829312)
CM - Cites: Free Radic Biol Med. 2014 Jul;72:285-95 (medline /24815113)
CM - Cites: Am J Ophthalmol. 1947 Apr;30(4):421-35 (medline /20256316)
CM - Cites: Chem Biol Interact. 2013 Dec 5;206(3):512-22 (medline /23816402)
CM - Cites: Wound Repair Regen. 2014 Mar-Apr;22(2):272-80 (medline /24635178)
CM - Cites: Arch Ophthal. 1947 Jan;37(1):25-41 (medline /20285740)
CM - Cites: J Ocul Pharmacol Ther. 2010 Oct;26(5):407-19 (medline /20925577)
CM - Cites: Cutan Ocul Toxicol. 2016 Dec;35(4):319-28 (medline /27002633)
DOCNO- medline/29141200

472 - TOXLINE
TI - Investigations of microbial degradation of polycyclic aromatic
hydrocarbons based on 13C-labeled phenanthrene in a soil co-contaminated
with trace elements using a plant assisted approach.
AU - Wawra A
AD - Institute of Soil Research, University of Natural Resources and Life Sciences
(BOKU), Konrad-Lorenz-Stra&szlig;e 24, 3430, Tulln, Austria.
AU - Friesl-Hanl W
AD - Environmental Resources &amp; Technologies, AIT Austrian Institute of
Technology GmbH, Konrad-Lorenz-Stra&szlig;e 24, 3430, Tulln, Austria.
Wolfgang.Friesl-Hanl@ait.ac.at.
AU - J�ger A
AD - Environmental Resources &amp; Technologies, AIT Austrian Institute of
Technology GmbH, Konrad-Lorenz-Stra&szlig;e 24, 3430, Tulln, Austria.
AU - Puschenreiter M
AD - Institute of Soil Research, University of Natural Resources and Life Sciences
(BOKU), Konrad-Lorenz-Stra&szlig;e 24, 3430, Tulln, Austria.
AU - Soja G
AD - Environmental Resources &amp; Technologies, AIT Austrian Institute of
Technology GmbH, Konrad-Lorenz-Stra&szlig;e 24, 3430, Tulln, Austria.
AU - Reichenauer T
AD - Environmental Resources &amp; Technologies, AIT Austrian Institute of
Technology GmbH, Konrad-Lorenz-Stra&szlig;e 24, 3430, Tulln, Austria.
AU - Watzinger A
AD - Environmental Resources &amp; Technologies, AIT Austrian Institute of
Technology GmbH, Konrad-Lorenz-Stra&szlig;e 24, 3430, Tulln, Austria.
SO - Environ Sci Pollut Res Int. 2018, Mar; 25(7):6364-6377. [Environmental
science and pollution research international]
AB - Co-contaminations of soils with organic and inorganic pollutants are a
frequent environmental problem. Due to their toxicity and recalcitrance,
the heterogeneous pollutants may persist in soil. The hypothesis of this
study was that degradation of polycyclic aromatic hydrocarbons (PAHs) is
enhanced if heavy metals in soil are immobilized and their bioavailability
reduced. For metal immobilization and enhanced biodegradation, distinct
mineral and organic soil amendments (iron oxides, gravel sludge, biochar)
were deployed in an incubation batch experiment. The second part of the
experiment consisted of a greenhouse pot experiment applying fast-growing
and pollution-tolerant woody plants (willow and black locust). Soil
amendments initially immobilized NH4NO3-extractable zinc, cadmium, and
lead; after 100 days of incubation, soil amendments showed reductions
only for cadmium and a tendency to enhance arsenic mobility. In order to
monitor the remediation success, a 13C-phenanthrene (PHE) label was
applied. 13C-phospholipid fatty acid analysis (13C-PLFA) further enabled
the identification of PHE-degrading soil microorganisms. Both experiments
exhibited a similar PLFA profile. Gram-negative bacteria (esp. cy17:0,
16:1&omega;7&thinsp;+&thinsp;6, 18:1&omega;7c) were the most significant
microbial group taking up 13C-PHE. Plants effectively increased the label
uptake by gram-positive bacteria and increased the biomass of the fungal
biomarker, although their contribution to the degradation process was
minor. Plants tended to prolong PAH dissipation in soil; at the end of the
experiment, however, all treatments showed equally low total PAH
concentrations in soil. While black locust plants tended not to take up
potentially toxic trace elements, willows accumulated them in their
leaves. The results of this study show that the chosen treatments did not
enhance the remediation of the experimental soil.
KW - 13C-Phospholipid fatty acid analysis
KW - Phytoremediation
KW - Polycyclic aromatic hydrocarbons
KW - Soil pollution
KW - Stable isotopic label
KW - Trace metals
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180302
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171216
STAT- In-Process
DOCNO- medline/29249024

473 - TOXLINE
TI - Metal Concentrations in e-Cigarette Liquid and Aerosol Samples: The
Contribution of Metallic Coils.
AU - Olmedo P
AD - Department of Legal Medicine and Toxicology, School of Medicine, University
of Granada, Granada, Spain
AU - Goessler W
AD - Institute of Chemistry, University of Graz, Graz, Austria
AU - Tanda S
AD - Institute of Chemistry, University of Graz, Graz, Austria
AU - Grau-Perez M
AD - Department of Environmental Health Sciences, Columbia University Mailman
School of Public Health, New York, New York, USA
AU - Jarmul S
AD - Department of Environmental Health and Engineering, Johns Hopkins Bloomberg
School of Public Health, Baltimore, Maryland, USA
AU - Aherrera A
AD - Department of Environmental Health and Engineering, Johns Hopkins Bloomberg
School of Public Health, Baltimore, Maryland, USA
AU - Chen R
AD - Department of Environmental Health and Engineering, Johns Hopkins Bloomberg
School of Public Health, Baltimore, Maryland, USA
AU - Hilpert M
AD - Department of Environmental Health Sciences, Columbia University Mailman
School of Public Health, New York, New York, USA
AU - Cohen JE
AD - Institute of Global Tobacco Control, Johns Hopkins Bloomberg School of Public
Health, Baltimore, Maryland, USA
AU - Navas-Acien A
AD - Department of Environmental Health Sciences, Columbia University Mailman
School of Public Health, New York, New York, USA
AU - Rule AM
AD - Department of Environmental Health and Engineering, Johns Hopkins Bloomberg
School of Public Health, Baltimore, Maryland, USA
SO - Environ Health Perspect. 2018, 02 21; 126(2):027010. [Environmental health
perspectives]
AB - BACKGROUND: Electronic cigarettes (e-cigarettes) generate an aerosol by
heating a solution (e-liquid) with a metallic coil. Whether metals are
transferred from the coil to the aerosol is unknown.
AB - OBJECTIVE: Our goal was to investigate the transfer of metals from the
heating coil to the e-liquid in the e-cigarette tank and the generated
aerosol.
AB - METHODS: We sampled 56 e-cigarette devices from daily e-cigarette users
and obtained samples from the refilling dispenser, aerosol, and remaining
e-liquid in the tank. Aerosol liquid was collected via deposition of
aerosol droplets in a series of conical pipette tips. Metals were reported
as mass fractions (&mu;g/kg) in liquids and converted to mass
concentrations (mg/m3) for aerosols.
AB - RESULTS: Median metal concentrations (&mu;g/kg) were higher in samples
from the aerosol and tank vs. the dispenser (all p < 0.001): 16.3 and
31.2 vs. 10.9 for Al; 8.38 and 55.4 vs. < 0.5 for Cr; 68.4 and 233 vs.
2.03 for Ni; 14.8 and 40.2 vs. 0.476 for Pb; and 515 and 426 vs. 13.1 for
Zn. Mn, Fe, Cu, Sb, and Sn were detectable in most samples. Cd was
detected in 0.0, 30.4, and 55.1% of the dispenser, aerosol, and tank
samples respectively. Arsenic was detected in 10.7% of dispenser samples
(median 26.7&mu;g/kg) and these concentrations were similar in aerosol and
tank samples. Aerosol mass concentrations (mg/m3) for the detected metals
spanned several orders of magnitude and exceeded current health-based
limits in close to 50% or more of the samples for Cr, Mn, Ni, and Pb.
AB - CONCLUSIONS: Our findings indicate that e-cigarettes are a potential
source of exposure to toxic metals (Cr, Ni, and Pb), and to metals that
are toxic when inhaled (Mn and Zn). Markedly higher concentrations in the
aerosol and tank samples versus the dispenser demonstrate that coil
contact induced e-liquid contamination. https://doi.org/10.1289/EHP2175.
LA - eng
IS - 1552-9924 (Electronic)
PT - Journal Article
TA - Environ Health Perspect
YR - 2018
DATE- 20180301
CITO- NLM
CS - United States
FJT - Environmental health perspectives
EDAT- 20180221
STAT- In-Data-Review
DOCNO- medline/29467105

474 - TOXLINE
TI - Coadsorption and subsequent redox conversion behaviors of As(III) and
Cr(VI) on Al-containing ferrihydrite.
AU - Ding Z
AD - School of Environmental Science and Engineering and Institute of
Environmental Health and Pollution Control, Guangdong University of Technology,
Guangzhou 510006, China.
AU - Fu F
AD - School of Environmental Science and Engineering and Institute of
Environmental Health and Pollution Control, Guangdong University of Technology,
Guangzhou 510006, China. Electronic address: fufenglian2006@163.com.
AU - Dionysiou DD
AD - Environmental Engineering and Science Program, Department of Biomedical,
Chemical and Environmental Engineering (DBCEE), University of Cincinnati, OH 45221-
0012, USA.
AU - Tang B
AD - School of Environmental Science and Engineering and Institute of
Environmental Health and Pollution Control, Guangdong University of Technology,
Guangzhou 510006, China.
SO - Environ Pollut. 2018, Apr; 235:660-669. [Environmental pollution (Barking,
Essex : 1987)]
AB - Naturally occurring ferrihydrite often contains various impurities, and Al
is one of the most prominent impurities. However, little is known about
how these impurities impact the physical and chemical properties of
ferrihydrite with respect to metal(loid) adsorption. In this study, a
series of Al-containing ferrihydrites were synthesized and exposed to a
mixed solution containing As(III) and Cr(VI). The results showed that the
two contaminants can be quickly adsorbed onto the surface of Al-containing
ferrihydrite under acidic and neutral conditions. With the increase of Al
molar percentage in ferrihydrites from 0 to 30, the adsorption capacity of
As(III) decreased, whereas it increased for Cr(VI). On the other hand,
with the increase of pH value from 3.0 to 11.0, the decreasing rate of
As(III) was accelerated first, then slowed down, whereas the Cr(VI)
decreasing rate slowed down dramatically. X-ray diffraction (XRD),
Brunauer-Emmett-Teller (BET) analysis method, transmission electron
microscopy (TEM) analysis, energy dispersive spectroscopy (EDS) mapping,
Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
(ATR-FTIR), and X-ray photoelectron spectroscopy (XPS) were employed to
characterize Al-containing ferrihydrite. Interestingly, it was found that
the redox transformation occurred between As(III) and Cr(VI) after the two
contaminants were coadsorbed onto the surface of Al-containing
ferrihydrite. The oxidation of As(III) to As(V) and reduction of Cr(VI) to
Cr(III) would greatly lower the environmental hazard of the As(III) and
Cr(VI).
KW - Al-containing ferrihydrite
KW - As(III)
KW - Coadsorption
KW - Cr(VI)
KW - Redox
RN - 0R0008Q3JB
RN - 18540-29-9
RN - 87PZU03K0K
RN - CPD4NFA903
RN - N712M78A8G
LA - eng
IS - 1873-6424 (Electronic)
PT - Journal Article
TA - Environ Pollut
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2018 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Environmental pollution (Barking, Essex : 1987)
EDAT- 20180112
STAT- MEDLINE
DOCNO- medline/29331898

475 - TOXLINE
TI - Heavy Metals in Indigenous Preparations Used for Sex Selection During
Pregnancy in India.
AU - Ganguli A
AD - , Patiala, India.
AU - Rai P
AD - Public Health Foundation of India, Indian Institute of Public Health, Delhi,
India.
AU - Balachandran S
AD - CSIR-Institute of Genomics and Integrative Biology, Delhi, India.
AU - Gupta R
AD - Government of Haryana, Chandigarh, India.
AU - Sharma R
AD - Science for Equity, Empowerment and Development (SEED) Division, Department
of Science and Technology, Delhi, India.
AU - Neogi SB
AD - Public Health Foundation of India, Indian Institute of Public Health, Delhi,
India. sutapa.bneogi@iiphd.org.
SO - Biol Trace Elem Res. 2018, Jun 16. [Biological trace element research]
AB - Indigenous preparations (IPs) have evoked a considerable interest in
alleviating infections and chronic diseases and improving wellbeing. While
such formulations have been a part of traditional practice in several
countries and many have been reviewed scientifically for their claims,
several of them until date remain to be investigated. A class of IPs for
sex selection by Indian pregnant women exists with an aim of begetting a
male offspring. In view of the leads obtained from our previous studies on
detrimental effects of the newborn, for instance stillbirths and
congenital malformations, we attempted to investigate the samples for
heavy metal toxicity. Three samples were chosen following phytochemical
analysis and reproductive toxicity of such preparations under in vivo
conditions. The selected samples were examined for heavy metals-lead,
cadmium, arsenic, and mercury using Microwave-assisted atomic absorption
spectroscopy. The upper limit level of lead, mercury, and cadmium was
found to be 18.56, 0.11, and 0.84 mg/kg respectively whereas arsenic
was not detected. The levels of lead and mercury were found to be
manifolds high in the IP samples that were primarily contributed by its
constituents. The results of our study indicate the potential risk
conferred upon, to both the mother and fetus on account of high levels of
lead, mercury, and cadmium.
KW - Heavy metals
KW - Indigenous preparations
KW - Lead
KW - Mercury
KW - Pregnancy
KW - Sex selection
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180617
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20180616
STAT- Publisher
DOCNO- medline/29909490

476 - TOXLINE
TI - Metal concentrations in traditional and herbal teas and their potential
risks to human health.
AU - de Oliveira LM
AD - Research Center of Soil Contamination and Remediation, Southwest Forestry
University, Kunming 650224, China; Soil and Water Science Department, University of
Florida, Gainesville, FL 32611, USA.
AU - Das S
AD - Soil and Water Science Department, University of Florida, Gainesville, FL
32611, USA.
AU - da Silva EB
AD - Soil and Water Science Department, University of Florida, Gainesville, FL
32611, USA.
AU - Gao P
AD - Soil and Water Science Department, University of Florida, Gainesville, FL
32611, USA.
AU - Gress J
AD - Soil and Water Science Department, University of Florida, Gainesville, FL
32611, USA.
AU - Liu Y
AD - Research Center of Soil Contamination and Remediation, Southwest Forestry
University, Kunming 650224, China. Electronic address: henryliu1008@163.com.
AU - Ma LQ
AD - Research Center of Soil Contamination and Remediation, Southwest Forestry
University, Kunming 650224, China; Soil and Water Science Department, University of
Florida, Gainesville, FL 32611, USA. Electronic address: lqma@ufl.edu.
SO - Sci Total Environ. 2018, Aug 15; 633:649-657. [The Science of the total
environment]
AB - Food and beverage consumption is an important route for human exposure to
metals. Traditional tea (Camellia sinensis) is a widely-consumed beverage,
which may contain toxic metals. This study determined total and infusion
concentrations of 5 metals including Al, As, Cd, Cr, and Pb in 47
traditional and herbal teas from 13 countries and assessed their potential
risks to human health. The data showed that herbal teas exhibited higher
As (0.26mgkg-1), Cd (0.19mgkg-1) and Pb (2.32mgkg-1) than traditional
teas. Black tea from India had high Cr at 31mgkg-1 while white tea from
China had low Cr at 0.39mgkg-1. Arsenic, Cd and Pb did not exceed the WHO
limit for medicinal plants excluding one herbal tea with 1.1mgkg-1 As and
26.4mgkg-1 Pb. However, Cr in 47% herbal teas and 73% traditional teas
exceeded the Canada limit of 2mgkg-1. Metal concentrations in tea
infusions were below the MCL for drinking water except for Al. Total Al
and its infusion was lower in herbal teas (47-1745mgkg-1 and
0.09-3.95mgL-1) than traditional teas (50.3-2517mgkg-1 and
0.02-7.51mgL-1), with 0.9-22% and 4-49% of the Al being soluble in
infusion. The Al concentrations in infusion in all black tea and 83, 75
and 25% of the green, oolong and herbal teas exceeded the secondary MCL
for drinking water at 0.2mgL-1. However, the weekly intake of Al from
drinking tea (0.001-0.39 and 0.003-0.56mgkg-1 for children and adults) was
lower than the provisional tolerable weekly intake for Al at 1.0mgkg-1.
Our data showed that it is important to consider metal intake from tea
consumptions, especially for Cr and Al in heavy tea drinkers.
KW - Al and Cr
KW - Camellia sinensis
KW - Heavy metals
KW - Infusion
KW - Risk assessment
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180512
CI - Copyright &copy; 2018. Published by Elsevier B.V.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180328
STAT- In-Process
DOCNO- medline/29597162

477 - TOXLINE
TI - Multiple approaches to assess human health risks from carcinogenic and
non-carcinogenic metals via consumption of five fish species from a large
reservoir in Turkey.
AU - Varol M
AD - Inonu University, Faculty of Fisheries, Malatya, Turkey. Electronic address:
memet.varol@inonu.edu.tr.
AU - S�nb�l MR
AD - East Mediterranean Transitional Zone Agricultural Research of Institute,
Kahramanmara&#351;, Turkey.
SO - Sci Total Environ. 2018, Aug 15; 633:684-694. [The Science of the total
environment]
KW - Arsenic
KW - Fish consumption advisories
KW - Freshwater fish
KW - Metals
KW - Risk assessment methods
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180512
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20180328
STAT- In-Data-Review
DOCNO- medline/29602109

478 - TOXLINE
TI - Identifying Plant Stress Responses to Roxarsone in Soybean Root Exudates:
New Insights from Two-Dimensional Correlation Spectroscopy.
AU - Fu QL
AD - University of Chinese Academy of Sciences , Beijing 100049, People's Republic
of China.
AU - Blaney L
AD - Department of Chemical, Biochemical and Environmental Engineering, University
of Maryland, Baltimore County , 1000 Hilltop Circle, Baltimore, Maryland 21250,
United States.
AU - Zhou DM
AD - Key Laboratory of Soil Environment and Pollution Remediation, Institute of
Soil Science, Chinese Academy of Sciences , Nanjing, Jiangsu 210008, People's
Republic of China.
SO - J Agric Food Chem. 2018, Jan 10; 66(1):53-62. [Journal of agricultural and
food chemistry]
AB - Roxarsone (ROX) is an organoarsenic feed additive of increasing interest
used in the poultry industry. Soybean responses to ROX stress were
investigated in root exudates (REs) using two-dimensional correlation
spectroscopy (2D-COS) with fluorescence and Fourier transform infrared
spectra. Environmentally relevant ROX concentrations caused negligible
toxicity to crop growth and photosynthesis activity but blackened soybean
roots at high concentrations. 2D-COS analysis revealed that the
protein-like fluorophore and C&#9552;C and C&#9552;O, aliphatic OH, and
polysaccharide C-O-H moieties in soybean REs were most sensitive to ROX
stress. Heterospectral 2D-COS results suggested that aromatic, amide I,
quinone, ketone, and aliphatic functional groups were the foundational
components of protein-like and short-wavelength excited humic-like
fluorophores in soybean REs. Carboxyl and phenolic moieties were related
to the long-wavelength excited humic-like fluorophore. Overall, 2D-COS
combined with molecular-based spectral analysis of REs provided an
innovative approach to characterize the physiological responses of crops
to contaminants at sublethal levels.
KW - plant responses
KW - root exudates
KW - roxarsone
KW - two-dimensional correlation spectroscopy
RN - 1406-65-1
RN - H5GU9YQL7L
RN - N712M78A8G
LA - eng
IS - 1520-5118 (Electronic)
PT - Journal Article
TA - J Agric Food Chem
YR - 2018
DATE- 20180215
CITO- NLM
CS - United States
CSET- IM
FJT - Journal of agricultural and food chemistry
EDAT- 20171228
STAT- MEDLINE
DOCNO- medline/29240415

479 - TOXLINE
TI - Comparative genomic inference suggests mixotrophic lifestyle for
Thorarchaeota.
AU - Liu Y
AD - Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education
and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University,
Shenzhen, China.
AU - Zhou Z
AD - Laboratory of Environmental Microbiology and Toxicology, School of Biological
Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
AU - Pan J
AD - Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education
and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University,
Shenzhen, China.
AU - Baker BJ
AD - Department of Marine Science, University of Texas Austin, Marine Science
Institute, 750 Channel View Drive, Port Aransas, TX, 78373, USA.
AU - Gu JD
AD - Laboratory of Environmental Microbiology and Toxicology, School of Biological
Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
AU - Li M
AD - Institute for Advanced Study, Shenzhen University, Shenzhen, China.
limeng848@szu.edu.cn.
SO - ISME J. 2018, Feb 14. [The ISME journal]
AB - Thorarchaeota are a new archaeal phylum within the Asgard superphylum,
whose ancestors have been proposed to play possible ecological roles in
cellular evolution. However, little is known about the lifestyles of these
uncultured archaea. To provide a better resolution of the ecological roles
and metabolic capacity of Thorarchaeota, we obtained Thorarchaeota genomes
reconstructed from metagenomes of different depth layers in mangrove and
mudflat sediments. These genomes from deep anoxic layers suggest the
presence of Thorarchaeota with the potential to degrade organic matter,
fix inorganic carbon, reduce sulfur/sulfate and produce acetate. In
particular, Thorarchaeota may be involved in ethanol production, nitrogen
fixation, nitrite reduction, and arsenic detoxification. Interestingly,
these Thorarchaeotal genomes are inferred to contain the
tetrahydromethanopterin and tetrahydrofolate Wood-Ljungdahl (WL) pathways
for CO2 reduction, and the latter WL pathway appears to have originated
from bacteria. These archaea are predicted to be able to use various
inorganic and organic carbon sources, possessing genes inferred to encode
ribulose bisphosphate carboxylase-like proteins (normally without RuBisCO
activity) and a near-complete Calvin-Benson-Bassham cycle. The existence
of eukaryotic selenocysteine insertion sequences and many genes for
proteins previously considered eukaryote-specific in Thorarchaeota genomes
provide new insights into their evolutionary roles in the origin of
eukaryotic cellular complexity. Resolving the metabolic capacities of
these enigmatic archaea and their origins will enhance our understanding
of the origins of eukaryotes and their roles in ecosystems.
LA - eng
IS - 1751-7370 (Electronic)
PT - Journal Article
TA - ISME J
YR - 2018
DATE- 20180215
CITO- NLM
CS - England
FJT - The ISME journal
EDAT- 20180214
STAT- Publisher
DOCNO- medline/29445130

480 - TOXLINE
TI - Applicability of an in vitro gastrointestinal digestion method to
evaluation of toxic elements bioaccessibility from algae for human
consumption.
AU - Desideri D
AD - a Department of Biomolecular Sciences , Urbino University "Carlo Bo" , Urbino
, Italy.
AU - Roselli C
AD - a Department of Biomolecular Sciences , Urbino University "Carlo Bo" , Urbino
, Italy.
AU - Feduzi L
AD - a Department of Biomolecular Sciences , Urbino University "Carlo Bo" , Urbino
, Italy.
AU - Ugolini L
AD - a Department of Biomolecular Sciences , Urbino University "Carlo Bo" , Urbino
, Italy.
AU - Meli MA
AD - a Department of Biomolecular Sciences , Urbino University "Carlo Bo" , Urbino
, Italy.
SO - J Toxicol Environ Health A. 2018, Feb 13:1-6. [Journal of toxicology and
environmental health. Part A]
AB - This study aimed to investigate the bioaccessibility of toxic elements,
including aluminum (Al), arsenic (As), nickel (Ni), cadmium (Cd), and lead
(Pb) in five commercial algae consumed by humans in Italy. The degree of
bioaccessibility of these elements may have important implications for
human health. Simulation of gastrointestinal tract (GIT) digestion was
divided into three stages through use of synthetic saliva, gastric, and
bile-pancreas solutions. After pre-treatment with a saliva solution,
seaweed samples underwent one of the following treatments: (1) simulated
gastric digestion only or (2) simulated complete GIT digestion (gastric
digestion followed by bile-pancreas digestion). The bioaccessibility of
these toxic elements ranged from approximately 5% to 73% and from 4% to
77% in gastric and GIT digestion, respectively. The bioaccessibility of Al
and Pb is poor (5-15%), As and Ni were fairly (40-55%), while Cd displayed
a high bioaccessibility. No significant differences in toxic elements
mobility was found between samples that only underwent gastric digestion
compared to those that underwent a complete GIT digestion.
LA - eng
IS - 1528-7394 (Print)
PT - Journal Article
TA - J Toxicol Environ Health A
YR - 2018
DATE- 20180213
CITO- NLM
CS - England
FJT - Journal of toxicology and environmental health. Part A
EDAT- 20180213
STAT- Publisher
DOCNO- medline/29437544

481 - TOXLINE
TI - Potential Toxic Metal Accumulation in Soil, Forage and Blood Plasma of
Buffaloes Sampled from Jhang, Pakistan.
AU - Khan ZI
AD - Department of Botany, University of Sargodha, Sargodha, Pakistan.
AU - Ugulu I
AD - Buca Faculty of Education, Dokuz Eylul University, Izmir, Turkey.
ilkerugulu@gmail.com.
AU - Umar S
AD - Department of Chemistry, Government College University, Sargodha, Pakistan.
AU - Ahmad K
AD - Department of Botany, University of Sargodha, Sargodha, Pakistan.
AU - Mehmood N
AD - Department of Zoology, University of Sargodha, Sargodha, Pakistan.
AU - Ashfaq A
AD - Department of Botany, University of Sargodha, Sargodha, Pakistan.
AU - Bashir H
AD - Department of Botany, University of Sargodha, Sargodha, Pakistan.
AU - Sohail M
AD - Department of Botany, University of Sargodha, Sargodha, Pakistan.
SO - Bull Environ Contam Toxicol. 2018, May 12. [Bulletin of environmental
contamination and toxicology]
AB - This study was conducted to determine the concentration of toxic metals in
soil, forage and blood plasma of lactating and non-lactating buffaloes in
the district Jhang, Punjab, Pakistan. Soil samples were collected from
varying distances from the road side. Plasma separation was achieved by
centrifugation. The concentration of arsenic (As), selenium (Se), cadmium
(Cd), chromium (Cr), iron (Fe), zinc (Zn), copper (Cu) and cobalt (Co)
were determined by using Atomic Absorption Spectrophotometer. The results
of the study showed that the mean As, Se and Cd concentrations in soil
samples were lower while Cr, Fe, Zn, Cu and Co were higher than the
official guidelines. In plasma samples, mean concentration values of Co,
Zn, Fe, Cd, Se and As were lower while Cu and Cr were higher than the
recommended concentrations. According to the results of the study there
was no potential exposure of toxicity in buffaloes of the study area.
KW - Blood plasma
KW - Buffalo
KW - Forage
KW - Metals
KW - Soil
LA - eng
IS - 1432-0800 (Electronic)
PT - Journal Article
TA - Bull Environ Contam Toxicol
YR - 2018
DATE- 20180512
CITO- NLM
CS - United States
FJT - Bulletin of environmental contamination and toxicology
EDAT- 20180512
STAT- Publisher
DOCNO- medline/29752519

482 - TOXLINE
TI - Mineralogical and geochemical characterization of waste rocks from a gold
mine in northeastern Thailand: application for environmental impact
protection.
AU - Assawincharoenkij T
AD - Department of Geology, Faculty of Science, Chulalongkorn University, Bangkok,
10330, Thailand.
AU - Hauzenberger C
AD - NAWI Graz Geocenter, Petrology and Geochemistry, University of Graz,
Universit�tsplatz 2, 8010, Graz, Austria.
AU - Ettinger K
AD - NAWI Graz Geocenter, Petrology and Geochemistry, University of Graz,
Universit�tsplatz 2, 8010, Graz, Austria.
AU - Sutthirat C
AD - Research Unit of Site Remediation on Metals Management from Industry and
Mining (Site Rem), Chulalongkorn University, Bangkok, 10330, Thailand.
c.sutthirat@gmail.com.
SO - Environ Sci Pollut Res Int. 2018, Feb; 25(4):3488-3500. [Environmental
science and pollution research international]
AB - Waste rocks from gold mining in northeastern Thailand are classified as
sandstone, siltstone, gossan, skarn, skarn-sulfide, massive sulfide,
diorite, and limestone/marble. Among these rocks, skarn-sulfide and
massive sulfide rocks have the potential to generate acid mine drainage
(AMD) because they contain significant amounts of sulfide minerals, i.e.,
pyrrhotite, pyrite, arsenopyrite, and chalcopyrite. Moreover, both sulfide
rocks present high contents of As and Cu, which are caused by the
occurrence of arsenopyrite and chalcopyrite, respectively. Another main
concern is gossan contents, which are composed of goethite, hydrous ferric
oxide (HFO), quartz, gypsum, and oxidized pyroxene. X-ray maps using
electron probe micro-analysis (EPMA) indicate distribution of some toxic
elements in Fe-oxyhydroxide minerals in the gossan waste rock. Arsenic (up
to 1.37 wt.%) and copper (up to 0.60 wt.%) are found in
goethite, HFO, and along the oxidized rim of pyroxene. Therefore, the
gossan rock appears to be a source of As, Cu, and Mn. As a result, massive
sulfide, skarn-sulfide, and gossan have the potential to cause
environmental impacts, particularly AMD and toxic element contamination.
Consequently, the massive sulfide and skarn-sulfide waste rocks should be
protected from oxygen and water to avoid an oxidizing environment, whereas
the gossan waste rocks should be protected from the formation of AMD to
prevent heavy metal contamination.
KW - AMD
KW - Gold mine
KW - Gossan
KW - Heavy metal
KW - Waste rock
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180214
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171120
STAT- In-Process
DOCNO- medline/29159434

483 - TOXLINE
TI - Assessing the release of copper from nanocopper-treated and conventional
copper-treated lumber into marine waters I: Concentrations and rates.
AU - Parks AN
AD - Southern California Coastal Water Research Project, Costa Mesa, California,
USA.
AU - Cantwell MG
AD - Office of Research and Development/National Health and Environmental Effects
Research Laboratory, Atlantic Ecology Division, US Environmental Protection Agency,
Narragansett, Rhode Island, USA.
AU - Katz DR
AD - Office of Research and Development/National Health and Environmental Effects
Research Laboratory, Atlantic Ecology Division, US Environmental Protection Agency,
Narragansett, Rhode Island, USA.
AU - Cashman MA
AD - Department of Geosciences, University of Rhode Island, Kingston, Rhode
Island, USA.
AU - Luxton TP
AD - Office of Research and Development/National Health and Environmental Effects
Research Laboratory, Land Remediation and Pollution Control Division Division, US
Environmental Protection Agency, Cincinnati, Ohio, USA.
AU - Ho KT
AD - Office of Research and Development/National Health and Environmental Effects
Research Laboratory, Atlantic Ecology Division, US Environmental Protection Agency,
Narragansett, Rhode Island, USA.
AU - Burgess RM
AD - Office of Research and Development/National Health and Environmental Effects
Research Laboratory, Atlantic Ecology Division, US Environmental Protection Agency,
Narragansett, Rhode Island, USA.
SO - Environ Toxicol Chem. 2018, Mar 25. [Environmental toxicology and
chemistry]
AB - Little is known about the release of metal engineered nanomaterials (ENMs)
from consumer goods, including lumber treated with micronized copper.
Micronized copper is a recent form of antifouling wood preservative
containing nanosized copper particles for use in pressure-treated lumber.
The present study investigated the concentrations released and the release
rate of total copper over the course of 133 d under freshwater, estuarine,
and marine salinity conditions (0, 1, 10, and 30&permil;) for several
commercially available pressure-treated lumbers: micronized copper azole
(MCA) at 0.96 and 2.4&thinsp;kg/m3 , alkaline copper quaternary (ACQ) at
0.30 and 9.6&thinsp;kg/m3 , and chromated copper arsenate (CCA) at
40&thinsp;kg/m3 . Lumber was tested as blocks and as sawdust. Overall,
copper was released from all treated lumber samples. Under leaching
conditions, total release ranged from 2 to 55% of the measured copper
originally in the lumber, with release rate constants from the blocks of
0.03 to 2.71 (units per day). Generally, measured release and modeled
equilibrium concentrations were significantly higher in the estuarine
conditions compared with freshwater or marine salinities, whereas rate
constants showed very limited differences between salinities. Furthermore,
organic carbon was released during the leaching and demonstrated a
significant relationship with released copper concentrations as a function
of salinity. The results indicate that copper is released into
estuarine/marine waters from multiple wood treatments including lumber
amended with nanoparticle-sized copper. Environ Toxicol Chem
2018;9999:1-13. Published 2018 Wiley Periodicals Inc. on behalf of SETAC.
This article is a US government work and, as such, is in the public domain
in the United States of America.
KW - Copper
KW - Environmental fate
KW - Ionic copper
KW - Leaching
KW - Nanomaterials
KW - Pressure-treated lumber
LA - eng
IS - 1552-8618 (Electronic)
PT - Journal Article
TA - Environ Toxicol Chem
YR - 2018
DATE- 20180511
CI - Published 2018 Wiley Periodicals Inc. on behalf of SETAC. This article is
a US government work and, as such, is in the public domain in the United
States of America.
CITO- NLM
CS - United States
FJT - Environmental toxicology and chemistry
EDAT- 20180325
STAT- Publisher
DOCNO- medline/29575152

484 - TOXLINE
TI - Composition and Elution Behavior of Various Elements from Printed Circuit
Boards, Cathode-ray Tube Glass, and Liquid-crystal Displays in Waste
Consumer Electronics.
AU - Inaba K
AD - Department of Environmental Science, Azabu University.
AU - Murata T
AD - National Institute for Environmental Studies.
AU - Yamamura S
AD - National Institute for Environmental Studies.
AU - Nagano M
AD - National Institute for Minamata Disease.
AU - Iwasaki K
AD - National Institute for Environmental Studies.
AU - Nakajima D
AD - National Institute for Environmental Studies.
AU - Takigami H
AD - National Institute for Environmental Studies.
SO - Anal Sci. 2018; 34(5):583-588. [Analytical sciences : the international
journal of the Japan Society for Analytical Chemistry]
AB - The contents and elution behavior of metals in consumer electronics parts
were determined so as to understand their maximum environmental risk.
Elements contained most in printed-circuit boards were Cu, Si, Br, Ca, Al,
Sn, Pb, Sb, Ba, Fe, Ni, Ti, and Zn; in cathode-ray tube glass were Si, Pb,
Ba, Sr, Zn, Zr, Ca, and Sb; in arsenic contained liquid-crystal displays
were Si, Ca, Sr, Ba, As, and Fe; and in antimony contained liquid-crystal
displays were Si, Ba, Ca, Sb, Sr, Fe, and Sn. The elements eluted most
from printed-circuit boards were Zn, Pb, and Cu; from cathode-ray tube
glass were Pb, Zn, B, Ba, and Si; and from liquid-crystal displays were B
and Si, and the toxic As and Sb. The amount eluted was greatest at acidic
pH. It was revealed that officially recommended 6-h-shaking with a pure
water test was insufficient to understand the real environmental risk of
waste electronics.
KW - Content test
KW - acid rain
KW - dumped electronics
KW - elution test
KW - long-term elution
KW - toxic elements
LA - eng
IS - 1348-2246 (Electronic)
PT - Journal Article
TA - Anal Sci
YR - 2018
DATE- 20180510
CITO- NLM
CS - Japan
FJT - Analytical sciences : the international journal of the Japan Society for
Analytical Chemistry
STAT- PubMed-not-MEDLINE
DOCNO- medline/29743431

485 - TOXLINE
TI - Long-term neurological and neuropsychological complications of sulfur
mustard and Lewisite mixture poisoning in Chinese victims exposed to
chemical warfare agents abandoned at the end of WWII.
AU - Isono O
AD - Department of Neurology and Rehabilitation Medicine, Kyoto Min-iren Daini
Chuo Hospital, Kyoto, Japan. Electronic address: o-isono@shinwakai-min.jp.
AU - Kituda A
AD - Department of Neurology and Rehabilitation Medicine, Higashi-Osaka Seikyo
Hospital, Osaka, Japan.
AU - Fujii M
AD - Department of Internal medicine, Shiba Clinic, Tokyo, Japan.
AU - Yoshinaka T
AD - Department of Cardiology, Kyoto Min-iren Chuo Hospital, Kyoto, Japan.
AU - Nakagawa G
AD - Department of Pediatrics, Mimihara General Hospital, Osaka, Japan.
AU - Suzuki Y
AD - Department of Neurology, Usioda General Hospital, Yokohama, Japan.
SO - Toxicol Lett. 2018, Sep 01; 293:9-15. [Toxicology letters]
AB - In August 2003, 44 victims were poisoned by chemical warfare agents (CWAs)
leaked from five drums that were excavated at a construction site in
Qiqihar, Northeast China. The drums were abandoned by the former Japanese
imperial army during World War II and contained a mixture of Sulfur
mustard (SM) and Lewisite. We carried out a total of six regular check-ups
between 2006 and 2014, and from 2008 we added neurological evaluations
including neuropsychological test and autonomic nervous function test in
parallel with medical follow-up as much as was possible. Severe autonomic
failure, such as hyperhidrosis, pollakiuria, diarrhoea, diminished libido,
and asthenia appeared in almost all victims. Polyneuropathy occurred in
35% of the victims and constricted vision occurred in 20% of them. The
rates of abnormal response on cold pressor test (CPT), active standing
test (AST), Heart rate variability (CVR-R), performed in 2014, were 63.1%,
31.6%, and 15.9%, respectively. On neuropsychological testing evaluated in
2010, a generalized cognitive decline was observed in 42% of the victims.
Memories and visuospatial abilities were affected in the remaining
victims. Finally, a 17-item PTSD questionnaire and the Beck Depression
Inventory evaluated in 2014 revealed long-lasting severe PTSD symptoms and
depression of the victims. Our findings suggest that an SM/Lewisite
compound have significant adverse consequences directly in cognitive and
emotional network and autonomic nervous systems in the brain.
KW - Autonomic nervous system
KW - Chemical warfare agents
KW - Lewisite
KW - Neurocognitive dysfunction
KW - PTSD
KW - Sulfur mustard
RN - 0N54LGU5WS
RN - T8KEC9FH9P
LA - eng
IS - 1879-3169 (Electronic)
PT - Case Reports
PT - Historical Article
PT - Journal Article
TA - Toxicol Lett
YR - 2018
DATE- 20180604
CI - Copyright &copy; 2018 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Toxicology letters
EDAT- 20180424
STAT- MEDLINE
DOCNO- medline/29702200

486 - TOXLINE
TI - Contents of Heavy Metals in Chinese Edible Herbs: Evidence from a Case
Study of Epimedii Folium.
AU - Yang XH
AD - Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health,
Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic
of China.
AU - Zhang HF
AD - Graduate University, Wuhan Institute of Botany, Chinese Academy of Sciences,
Wuhan, 430074, People's Republic of China. isaacsau@sohu.com.
AU - Niu LL
AD - International Joint Research Center of Shaanxi Province for Food and Health
Sciences, Key Laboratory of Ministry of Education for Medicinal Resources and
Natural Pharmaceutical Chemistry, Shaanxi Normal University, Xi'an, 710062,
People's Republic of China.
AU - Wang Y
AD - Graduate University, Wuhan Institute of Botany, Chinese Academy of Sciences,
Wuhan, 430074, People's Republic of China.
AU - Lai JH
AD - Key Laboratory of Trace Elements and Endemic Diseases of Ministry of Health,
Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic
of China. laijh1011@mail.xjtu.edu.cn.
SO - Biol Trace Elem Res. 2018, Mar; 182(1):159-168. [Biological trace element
research]
AB - Toxic heavy metal contamination in Chinese edible herbs has raised a
worldwide concern. In this study, heavy metals in Epimedii Folium, an
edible medicinal plant in China, were quantitatively analyzed. Variations
of heavy metals in different species, in various organs (i.e., leaves,
stems, and roots), in wild-growing and cultivated plants, and in 35 market
samples of Epimedii Folium, were systematically investigated. In all of
Epimedium samples, Hg (mercury) was not detectable (0.00 &mu;g/g).
Four species, Epimedium pubescens, Epimedium sagittatum, Epimedium
brevicornu, and Epimedium wushanense, were found to contain Cu (copper)
and Pb (lead). And contents of Cu and Pb in E. brevicornu were
significantly higher than those in other species (P < 0.01).
In wild-growing and cultivated Epimedium plants, Cd (cadmium) and As
(arsenic) were not detectable, and concentrations of Cu and Pb in
wild-growing plants were significantly higher than those in cultivated
plants (P < 0.01). Cd was not detectable in leaves, roots,
and stems, while organ specificity was apparent in the distribution of Cu,
As, and Pb. And the highest levels of Cu and Pb were observed in roots and
leaves, respectively. In Chinese markets, several samples of Epimedii
Folium contained excessive Cu, Cd, As, and Pb beyond the national
permissible limits. In summary, there was a large variation of heavy
metals among Epimedii Folium samples, and Cu and Pb were the most
important heavy metals contaminating the edible medicinal plant.
Application of Epimedii Folium to drug and food industries will need to
focus more on toxic heavy metal contamination.
KW - Epimedii Folium
KW - Heavy metals
KW - Market samples
KW - Risk assessment
KW - Species
LA - eng
IS - 1559-0720 (Electronic)
PT - Journal Article
TA - Biol Trace Elem Res
YR - 2018
DATE- 20180211
CITO- NLM
CS - United States
FJT - Biological trace element research
EDAT- 20170616
STAT- In-Process
DOCNO- medline/28620728

487 - TOXLINE
TI - A three year study of metal levels in skin biopsies of whales in the Gulf
of Mexico after the Deepwater Horizon oil crisis.
AU - Wise JP Jr
AD - Wise Laboratory of Environmental and Genetic Toxicology, Department of
Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St,
Louisville, KY, 40292, USA.
AU - Wise JTF
AD - Wise Laboratory of Environmental and Genetic Toxicology, Department of
Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St,
Louisville, KY, 40292, USA; Department of Pharmacology and Nutritional Sciences,
Division of Nutritional Sciences, College of Medicine, University of Kentucky,
Lexington, KY 40536, USA.
AU - Wise CF
AD - Wise Laboratory of Environmental and Genetic Toxicology, Department of
Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St,
Louisville, KY, 40292, USA.
AU - Wise SS
AD - Wise Laboratory of Environmental and Genetic Toxicology, Department of
Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St,
Louisville, KY, 40292, USA.
AU - Gianios C Jr
AD - Wise Laboratory of Environmental and Genetic Toxicology, Department of
Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St,
Louisville, KY, 40292, USA.
AU - Xie H
AD - Wise Laboratory of Environmental and Genetic Toxicology, Department of
Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St,
Louisville, KY, 40292, USA.
AU - Walter R
AD - Texas State University, Department of Chemistry &amp; Biochemistry, 419
Centennial Hall, 601 University Drive, San Marcos, TX 78666, USA.
AU - Boswell M
AD - Texas State University, Department of Chemistry &amp; Biochemistry, 419
Centennial Hall, 601 University Drive, San Marcos, TX 78666, USA.
AU - Zhu C
AD - West China School of Public Health, Sichuan University, No.17 Section 3,
Renmin South Road, Chengdu, Sichuan 610044, China.
AU - Zheng T
AD - Brown University, Rhode Island, CT, USA.
AU - Perkins C
AD - Center for Environmental Sciences and Engineering, University of Connecticut,
Storrs, CT, United States.
AU - Wise JP Sr
AD - Wise Laboratory of Environmental and Genetic Toxicology, Department of
Pharmacology and Toxicology, University of Louisville, 505 S. Hancock St,
Louisville, KY, 40292, USA. Electronic address: john.wise@louisville.edu.
SO - Comp Biochem Physiol C Toxicol Pharmacol. 2018, Feb; 205:15-25.
[Comparative biochemistry and physiology. Toxicology & pharmacology : CBP]
AB - In response to the explosion of the Deepwater Horizon and the massive
release of oil that followed, we conducted three annual research voyages
to investigate how the oil spill would impact the marine offshore
environment. Most investigations into the ecological and toxicological
impacts of the Deepwater Horizon Oil crisis have mainly focused on the
fate of the oil and dispersants, but few have considered the release of
metals into the environment. From studies of previous oil spills, other
marine oil industries, and analyses of oil compositions, it is evident
that metals are frequently encountered. Several metals have been reported
in the MC252 oil from the Deepwater Horizon oil spill, including the
nonessential metals aluminum, arsenic, chromium, nickel, and lead;
genotoxic metals, such as these are able to damage DNA and can
bioaccumulate in organisms resulting in persistent exposure. In the Gulf
of Mexico, whales are the apex species; hence we collected skin biopsies
from sperm whales (Physeter macrocephalus), short-finned pilot whales
(Globicephala macrorhynchus), and Bryde's whales (Balaenoptera edeni). The
results from our three-year study of monitoring metal levels in whale skin
show (1) genotoxic metals at concentrations higher than global averages
previously reported and (2) patterns for MC252-relevant metal
concentrations decreasing with time from the oil spill.
KW - Chromium
KW - Deepwater Horizon
KW - Gulf of Mexico
KW - Metals
KW - Nickel
KW - Oil spill
KW - Whales
RN - 0R0008Q3JB
RN - 7OV03QG267
LA - eng
IS - 1532-0456 (Print)
PT - Comparative Study
PT - Journal Article
TA - Comp Biochem Physiol C Toxicol Pharmacol
YR - 2018
DATE- 20180611
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
CSET- IM
FJT - Comparative biochemistry and physiology. Toxicology &amp; pharmacology :
CBP
EDAT- 20171220
STAT- MEDLINE
CM - Cites: Environ Sci Technol. 2014;48(1):93-103 (medline /24350796)
CM - Cites: Ecotoxicol Environ Saf. 2013 Nov;97:166-75 (medline /23993648)
CM - Cites: Talanta. 2006 Jul 15;69(5):1072-8 (medline /18970684)
CM - Cites: Environ Sci Technol. 2014;48(3):1993-2000 (medline /24401096)
CM - Cites: Arch Toxicol. 2016 Apr;90(4):829-37 (medline /25998020)
CM - Cites: Am J Med. 2013 Nov;126(11):966-74 (medline /24050487)
CM - Cites: Mar Pollut Bull. 2017 Apr 15;117(1-2):462-477 (medline /28214010)
CM - Cites: Environ Sci Technol. 2015 Jul 21;49(14):8769-76 (medline /26115348)
CM - Cites: Environ Sci Technol. 2010 Dec 15;44(24):9383-9 (medline /21073188)
CM - Cites: Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20260-7 (medline
/22187459)
CM - Cites: Environ Mol Mutagen. 2011 Jan;52(1):43-9 (medline /20839228)
CM - Cites: Environ Sci Technol. 2014;48(5):2997-3006 (medline /24552566)
CM - Cites: Aquat Toxicol. 2013 Jun 15;134-135:74-81 (medline /23584427)
CM - Cites: J Acoust Soc Am. 2012 Mar;131(3):2306-14 (medline /22423725)
CM - Cites: Environ Pollut. 2003;121(3):345-7 (medline /12685763)
CM - Cites: Ecotoxicology. 2015 Nov;24(9):1831-47 (medline /26209168)
CM - Cites: Comp Biochem Physiol C Toxicol Pharmacol. 2012 Jan;155(1):143-50
(medline /21466859)
CM - Cites: Environ Sci Technol. 2012 Dec 4;46(23):12787-95 (medline /23131011)
CM - Cites: Mar Pollut Bull. 2013 Nov 15;76(1-2):158-69 (medline /24064373)
CM - Cites: Environ Sci Technol. 2013 Mar 5;47(5):2161-8 (medline /23383592)
CM - Cites: Mol Ecol. 2012 Feb;21(3):732-44 (medline /21951561)
CM - Cites: Chem Biodivers. 2004 Nov;1(11):1708-15 (medline /17191811)
CM - Cites: Environ Sci Technol. 2010 Dec 15;44(24):9431-7 (medline /21073185)
CM - Cites: Sci Total Environ. 2002 Jun 26;292(3):247-54 (medline /12146523)
CM - Cites: Environ Res. 2016 Apr;146:108-15 (medline /26745734)
CM - Cites: Mar Pollut Bull. 2016 Jun 15;107(1):216-223 (medline /27084200)
CM - Cites: Chemosphere. 2009 Jun;75(11):1461-7 (medline /19324391)
CM - Cites: Science. 2003 Dec 19;302(5653):2082-6 (medline /14684812)
CM - Cites: Proc Biol Sci. 2015 Nov 7;282(1818):20151944 (medline /26538595)
CM - Cites: Toxicol Ind Health. 2013 Mar;29(2):162-8 (medline /22082827)
CM - Cites: Mar Pollut Bull. 2017 Apr 15;117(1-2):392-405 (medline /28233527)
DOCNO- medline/29277452

488 - TOXLINE
TI - Health risk assessment of instant noodles commonly consumed in Port
Harcourt, Nigeria.
AU - Charles IA
AD - Department of Oncology, School of Medicine,Faculty of Medicine and Health
Sciences,, City Hospital Campus, University of Nottingham, NG5 1PB, Nottingham,
United Kingdom. Iniobong.charles@nottingham.ac.uk.
AU - Ogbolosingha AJ
AD - Department of Biochemistry, Faculty of Science, Federal University Otuoke,
PMB 126, Otuoke, Nigeria.
AU - Afia IU
AD - Department of Biochemistry, University of Port Harcourt, PMB 5323, Choba,
Nigeria.
SO - Environ Sci Pollut Res Int. 2018, Jan; 25(3):2580-2587. [Environmental
science and pollution research international]
AB - The current study investigated the levels of some heavy metals [lead (Pb),
arsenic (As), nickel (Ni), mercury (Hg), copper (Cu), cadmium (Cd),
aluminum (Al), and chromium (Cr)] and polycyclic aromatic hydrocarbons
(PAHs) in six brands of instant noodles (CFN, GFC, NGP, GAA, CUN, and FCS)
commonly consumed in Port Harcourt, Nigeria. Risks of consumption of
contaminated noodles were also assessed. Heavy metal content and PAHs were
determined using flame atomic absorption spectrophotometer and gas
chromatography, respectively. Concentrations of heavy metals as Pb, Ni,
Cu, Al, and Cr were detected while As, Hg, and Cd were not detected in
noodles. High average concentrations (mean &plusmn; SD mg/kg) of Pb were
observed in brands CFN (3.163 &plusmn; 0.21) and GFC
(1.022 &plusmn; 0.08) which were significantly higher
(P &le; 0.05) than in NGP (0.043 &plusmn; 0.15) and
GAA (0.276 &plusmn; 0.18), although all were above WHO
permissible limits (0.025 mg/kg). Target Hazard Quotient and Hazard
Index for Pb were > 1 in brands CFN and GFC indicating
unacceptable risk. Results of PAHs showed brands had total PAHs (mg/kg) in
the order CFN > CUN > GAA > NGP > FCS > GFC. Although
carcinogenic risks associated with these noodles are within permissible
range, consumption of CFN and GFC could pose greater health risk to
consumers. Long-term consumption of brands CUN, CFN, and GAA may have
higher probability of carcinogenesis among consumers. We therefore
recommend more diligent regulatory policies and monitoring by relevant
government agencies (WHO, NAFDAC, CPC, and SON) to ensure wholesome
noodles get to consumers.
KW - Carcinogenic risk
KW - Health risk
KW - Heavy metals
KW - Instant noodles
KW - PAHs
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180210
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171111
STAT- In-Process
CM - Cites: Environ Pollut. 2011 Oct;159(10):2575-85 (medline /21752504)
CM - Cites: Sci Total Environ. 2014 Jan 15;468-469:843-53 (medline /24076505)
CM - Cites: Ecotoxicol Environ Saf. 2012 Jul;81:55-64 (medline /22633085)
CM - Cites: Sci Total Environ. 2002 Feb 21;285(1-3):177-85 (medline /11874040)
CM - Cites: J Inorg Biochem. 2000 Apr;79(1-4):241-4 (medline /10830873)
CM - Cites: Southeast Asian J Trop Med Public Health. 2008 Mar;39(2):335-40
(medline /18564723)
CM -Cites: BMC Public Health. 2012 Jun 18;12:439 (medline /22709383)
CM -Cites: Sci Total Environ. 2005 Nov 1;350(1-3):28-37 (medline /16227070)
CM -Cites: Br Med Bull. 2003;68:167-82 (medline /14757716)
CM -Cites: Analyst. 1977 Apr;102(1213):225-68 (medline /327849)
CM -Cites: Int J Environ Res Public Health. 2016 Sep 23;13(10 ): (medline
/27669274)
CM - Cites: Environ Monit Assess. 2016 May;188(5):261 (medline /27037696)
CM - Cites: Chemosphere. 2011 Sep;85(1):67-73 (medline /21700309)
CM - Cites: Clin Biochem Rev. 2008 May;29(2):63-70 (medline /18787644)
CM - Cites: Crit Rev Toxicol. 2008;38(3):173-90 (medline /18324515)
CM - Cites: Toxicology. 2017 May 1;382:16-23 (medline /28315714)
CM - Cites: Sci Total Environ. 2009 Feb 15;407(5):1551-61 (medline /19068266)
DOCNO- medline/29128944

489 - TOXLINE
TI - Metal contamination in quail meat: residues, sources, molecular
biomarkers, and human health risk assessment.
AU - Darwish WS
AD - Food Control Department, Faculty of Veterinary Medicine, Zagazig University,
Zagazig, 44519, Egypt. wagehdarwish@yahoo.ca.
AU - Atia AS
AD - Department of Veterinary Hygiene, Faculty of Veterinary Medicine, Zagazig
University, Zagazig, 44519, Egypt.
AU - Khedr MHE
AD - Department of Veterinary Hygiene, Faculty of Veterinary Medicine, Zagazig
University, Zagazig, 44519, Egypt.
AU - Eldin WFS
AD - Educational Veterinary Hospital, Faculty of Veterinary Medicine, Zagazig
University, Zagazig, 44519, Egypt.
SO - Environ Sci Pollut Res Int. 2018, May 10. [Environmental science and
pollution research international]
AB - Quail meat is an emerging source of high-quality animal protein. Quails
are exposed to a wide range of xenobiotics such as heavy metals. In this
study, residual concentrations of four toxic metals, of significant public
health importance, including cadmium (Cd), lead (Pb), arsenic (As), and
nickel (Ni), were determined in edible tissues of quails. In addition,
metal loads were measured in water, feed, and litter samples collected
from same quail farms as possible sources for quail exposure to heavy
metals. The possible use of metallothionein (MT) and heat shock protein 70
(Hsp70) as molecular biomarkers of exposure to heavy metals was further
investigated. Furthermore, the dietary intake and the potential risk
assessment of the examined heavy metals among children and adults were
calculated. The edible tissues of quails contained high concentrations of
four heavy metals (contents (ppm/ww) ranging from 0.02 to 0.32 in Cd, 0.05
to 1.96 in Pb, 0.002 to 0.32 in As, and 1.17 to 3.94 in Ni), which
corresponded to the high contents of these metals in the feeds, water, and
litter. MT and Hsp70 mRNA expressions showed positive correlations with
the concentrations of heavy metals in tissues indicating the possibility
to use these proteins as biomarkers for quail's exposure to toxic metals.
Dietary intake of quail meat and risk assessment revealed potential risks
especially for children after prolonged exposure to the examined metals.
Thus, legislations should be established and continuous screening of metal
residues should be adopted in order to reduce the toxic metal
concentrations in feeds and drinking water for quails. Reduction of
exposure to heavy metals subsequently would lead to minimization of
exposure of such toxicants through consumption of quail meat.
KW - Biomarkers
KW - Heavy metals
KW - Quail
KW - Risk assessment
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180511
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20180510
STAT- Publisher
DOCNO- medline/29748799

490 - TOXLINE
TI - Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced
Hepatotoxicity via Reducing Oxidative Stress, MAPK Activation, and
Apoptotic Cell Death Pathway.
AU - Das S
AD - Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata 700032, India.
AU - Joardar S
AD - Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata 700032, India.
AU - Manna P
AD - Biological Science and Technology Division, CSIR-North East Institute of
Science and Technology, Jorhat, Assam 785006, India.
AU - Dua TK
AD - Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata 700032, India.
AU - Bhattacharjee N
AD - Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata 700032, India.
AU - Khanra R
AD - Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata 700032, India.
AU - Bhowmick S
AD - Department of Chemical Technology, University of Calcutta, Kolkata 700009,
India.
AU - Kalita J
AD - Biological Science and Technology Division, CSIR-North East Institute of
Science and Technology, Jorhat, Assam 785006, India.
AU - Saha A
AD - Department of Chemical Technology, University of Calcutta, Kolkata 700009,
India.
AU - Ray S
AD - Department of Pharmaceutical Sciences, Assam University, Silchar 788011,
India.
AU - De Feo V
AD - Department of Pharmacy, University of Salerno, Fisciano 84084, Italy.
AU - Dewanjee S
AD - Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata 700032, India.
SO - Oxid Med Cell Longev. 2018; 2018:1421438. [Oxidative medicine and cellular
longevity]
AB - The present studies have been executed to explore the protective mechanism
of carnosic acid (CA) against NaAsO2-induced hepatic injury. CA exhibited
a concentration dependent (1-4&thinsp;&mu;M) increase in cell viability
against NaAsO2 (12&thinsp;&mu;M) in murine hepatocytes. NaAsO2 treatment
significantly enhanced the ROS-mediated oxidative stress in the hepatic
cells both in in vitro and in vivo systems. Significant activation of
MAPK, NF-&kappa;B, p53, and intrinsic and extrinsic apoptotic signaling
was observed in NaAsO2-exposed hepatic cells. CA could significantly
counteract with redox stress and ROS-mediated signaling and thereby
attenuated NaAsO2-mediated hepatotoxicity. NaAsO2 (10&thinsp;mg/kg)
treatment caused significant increment in the As bioaccumulation,
cytosolic ATP level, DNA fragmentation, and oxidation in the liver of
experimental mice (n = 6). The serum biochemical and haematological
parameters were significantly altered in the NaAsO2-exposed mice (n = 6).
Simultaneous treatment with CA (10 and 20&thinsp;mg/kg) could
significantly reinstate the NaAsO2-mediated toxicological effects in the
liver. Molecular docking and dynamics predicted the possible interaction
patterns and the stability of interactions between CA and signal proteins.
ADME prediction anticipated the drug-likeness characteristics of CA.
Hence, there would be an option to employ CA as a new therapeutic agent
against As-mediated toxic manifestations in future.
LA - eng
IS - 1942-0994 (Electronic)
PT - Journal Article
TA - Oxid Med Cell Longev
YR - 2018
DATE- 20180603
CITO- NLM
CS - United States
FJT - Oxidative medicine and cellular longevity
EDAT- 20180502
STAT- In-Process
CM - Cites: Food Chem Toxicol. 2009 Oct;47(10):2679-85 (medline /19660513)
CM - Cites: Z Lebensm Unters Forsch. 1992 Aug;195(2):99-103 (medline /1529648)
CM - Cites: Biochem Biophys Res Commun. 2015 Jan 9;456(2):643-8 (medline
/25499816)
CM - Cites: J Vis Exp. 2015 Aug 01;(102):e52697 (medline /26273842)
CM - Cites: Xenobiotica. 1992 Feb;22(2):257-68 (medline /1378672)
CM - Cites: Bioorg Med Chem Lett. 2004 Apr 19;14(8):1943-6 (medline /15050633)
CM - Cites: Oncogene. 1999 Nov 22;18(49):6910-24 (medline /10602466)
CM - Cites: Nucleic Acids Res. 2000 Jan 1;28(1):235-42 (medline /10592235)
CM - Cites: Phytochemistry. 2015 Jul;115:9-19 (medline /25639596)
CM - Cites: J Cell Biochem. 2013 Oct;114(10):2334-45 (medline /23733596)
CM - Cites: J Photochem Photobiol B. 1999 Jan;48(1):63-7 (medline /10205880)
CM - Cites: Analyst. 1995 Mar;120(3):917-24 (medline /7741255)
CM - Cites: Biochem Biophys Res Commun. 1997 Jan 3;230(1):115-9 (medline
/9020024)
CM - Cites: PLoS One. 2015 Oct 16;10(10):e0139831 (medline /26473485)
CM - Cites: Nat Rev Mol Cell Biol. 2014 Jan;15(1):49-63 (medline /24355989)
CM - Cites: Food Chem Toxicol. 2013 Oct;60:188-98 (medline /23891759)
CM - Cites: Postgrad Med J. 2003 Jul;79(933):391-6 (medline /12897217)
CM - Cites: Int J Radiat Biol Relat Stud Phys Chem Med. 1980 Feb;37(2):213-7
(medline /6966267)
CM - Cites: Neuroreport. 2008 Aug 27;19(13):1301-4 (medline /18695511)
CM - Cites: Pharmacol Toxicol. 2001 Jul;89(1):1-5 (medline /11484904)
CM - Cites: Redox Rep. 2016 Jul;21(4):147-54 (medline /26066906)
CM - Cites: J Appl Toxicol. 2011 Mar;31(2):95-107 (medline /21321970)
CM - Cites: EMBO Rep. 2005 Jul;6 Spec No:S39-44 (medline /15995660)
CM - Cites: Food Chem Toxicol. 2010 May;48(5):1210-7 (medline /20156518)
CM - Cites: Biosci Rep. 1999 Feb;19(1):11-5 (medline /10379902)
CM - Cites: Free Radic Biol Med. 2010 Mar 15;48(6):749-62 (medline /20045723)
CM - Cites: Food Chem Toxicol. 2011 Dec;49(12):3090-7 (medline /21930180)
CM - Cites: Oncogene. 2004 Apr 12;23(16):2838-49 (medline /15077147)
CM -Cites: Chem Rev. 2013 Oct 9;113(10):7769-92 (medline /23808632)
CM -Cites: Food Chem Toxicol. 2010 Jan;48(1):326-35 (medline /19852998)
CM -Cites: Food Chem Toxicol. 2013 May;55:78-91 (medline /23291325)
CM -Cites: Food Chem Toxicol. 2017 Jul;105:322-336 (medline /28478100)
CM -Cites: J Pharmacol Exp Ther. 2001 Aug;298(2):461-8 (medline /11454906)
CM -Cites: MethodsX. 2015 Nov 07;2:440-5 (medline /26740924)
CM -Cites: Planta Med. 2007 Sep;73(11):1190-1 (medline /17713873)
CM -Cites: J Biol Chem. 2008 Jul 4;283(27):18969-79 (medline /18482988)
CM -Cites: J Biol Chem. 2004 Jul 30;279(31):32700-8 (medline /15161912)
CM -Cites: Clin Lab. 2011;57(11-12):859-66 (medline /22239015)
CM -Cites: Cancer Biol Ther. 2004 Feb;3(2):156-61 (medline /14764989)
CM -Cites: Int J Environ Res Public Health. 2010 May;7(5):2018-32 (medline
/20623008)
CM - Cites: Toxicol Appl Pharmacol. 2014 May 1;276(3):165-70 (medline
/24582688)
CM - Cites: Pharmacol Rep. 2010 Nov-Dec;62(6):1170-7 (medline /21273674)
CM - Cites: Cell Res. 2011 Jan;21(1):103-15 (medline /21187859)
CM - Cites: Biomed Pharmacother. 2017 Oct;94:726-741 (medline /28802226)
CM - Cites: Annu Rev Pharmacol Toxicol. 1997;37:397-419 (medline /9131259)
CM - Cites: Neurosci Lett. 2008 Apr 4;434(3):260-5 (medline /18329808)
CM - Cites: Front Pharmacol. 2017 May 08;8:251 (medline /28533752)
CM - Cites: Environ Health Perspect. 2011 Oct;119(10):1356-63 (medline
/21684831)
CM - Cites: Biochim Biophys Acta. 1998 Aug 10;1366(1-2):139-49 (medline
/9714780)
CM - Cites: Eur J Pharmacol. 2016 Nov 15;791:8-24 (medline /27568833)
CM - Cites: Free Radic Biol Med. 2010 Jun 1;48(11):1465-84 (medline /20188823)
CM - Cites: J Transl Med. 2015 Mar 05;13:81 (medline /25890105)
CM - Cites: Environ Toxicol Pharmacol. 2010 Jan;29(1):64-9 (medline /21787584)
DOCNO- medline/29854073

491 - TOXLINE
TI - Toxicity of formulants and heavy metals in glyphosate-based herbicides and
other pesticides.
AU - Defarge N
AD - University of Caen Normandy, Department of Biology and Network on Risks,
Quality and Sustainable Environment MRSH, Esplanade de la Paix, 14032 Caen Cedex,
France.
AU - Spiroux de Vend�mois J
AD - CRIIGEN, 81 Rue Monceau, 75008 Paris, France.
AU - S�ralini GE
AD - University of Caen Normandy, Department of Biology and Network on Risks,
Quality and Sustainable Environment MRSH, Esplanade de la Paix, 14032 Caen Cedex,
France.
SO - Toxicol Rep. 2018; 5:156-163. [Toxicology reports]
AB - The major pesticides of the world are glyphosate-based herbicides (GBH),
and their toxicity is highly debated. To understand their mode of action,
the comparative herbicidal and toxicological effects of glyphosate (G)
alone and 14 of its formulations were studied in this work, as a model for
pesticides. GBH are mixtures of water, with commonly 36-48% G claimed as
the active principle. As with other pesticides, 10-20% of GBH consist of
chemical formulants. We previously identified these by mass spectrometry
and found them to be mainly families of petroleum-based oxidized
molecules, such as POEA, and other contaminants. We exposed plants and
human cells to the components of formulations, both mixed and separately,
and measured toxicity and human cellular endocrine disruption below the
direct toxicity experimentally measured threshold. G was only slightly
toxic on plants at the recommended dilutions in agriculture, in contrast
with the general belief. In the short term, the strong herbicidal and
toxic properties of its formulations were exerted by the POEA formulant
family alone. The toxic effects and endocrine disrupting properties of the
formulations were mostly due to the formulants and not to G. In this work,
we also identified by mass spectrometry the heavy metals arsenic,
chromium, cobalt, lead and nickel, which are known to be toxic and
endocrine disruptors, as contaminants in 22 pesticides, including 11
G-based ones. This could also explain some of the adverse effects of the
pesticides. In in vivo chronic regulatory experiments that are used to
establish the acceptable daily intakes of pesticides, G or other declared
active ingredients in pesticides are assessed alone, without the
formulants. Considering these new data, this assessment method appears
insufficient to ensure safety. These results, taken together, shed a new
light on the toxicity of these major herbicides and of pesticides in
general.
KW - Arsenic
KW - Formulant
KW - G, glyphosate
KW - GBH, glyphosate-based herbicide
KW - Glyphosate
KW - Heavy metals
KW - Herbicide
KW - POEA
KW - POEA, polyoxyethylenamines (polyethoxylated tallowamine)
KW - Pesticide
KW - QAC, quaternary ammonium compounds
KW - R, Roundup
KW - Roundup
LA - eng
IS - 2214-7500 (Electronic)
PT - Journal Article
TA - Toxicol Rep
YR - 2018
DATE- 20180210
CITO- NLM
CS - Ireland
FJT - Toxicology reports
EDAT- 20171230
STAT- PubMed-not-MEDLINE
CM - Cites: Environ Health Perspect. 2005 Jun;113(6):716-20 (medline /15929894)
CM - Cites: J Chromatogr B Analyt Technol Biomed Life Sci. 2007 May
1;850(1-2):412-6 (medline /17270504)
CM - Cites: Chemosphere. 2003 Feb;50(7):871-901 (medline /12504127)
CM - Cites: J Epidemiol Community Health. 2016 Aug;70(8):741-5 (medline
/26941213)
CM - Cites: J Agric Food Chem. 2014 May 14;62(19):4227-40 (medline /24754346)
CM - Cites: Hum Exp Toxicol. 2017 Jun;36(6):554-564 (medline /28539089)
CM - Cites: PLoS One. 2011;6(11):e24139 (medline /22125591)
CM - Cites: Food Chem. 2014 Sep 1;158:473-9 (medline /24731372)
CM - Cites: Reprod Toxicol. 2002 Jan-Feb;16(1):45-56 (medline /11934531)
CM - Cites: Cell Biol Toxicol. 2005 Mar;21(2):127-37 (medline /16142586)
CM - Cites: Curr Environ Health Rep. 2016 Mar;3(1):1-12 (medline /26875182)
CM - Cites: Chem Res Toxicol. 2009 Jan;22(1):97-105 (medline /19105591)
CM - Cites: Comp Biochem Physiol C Toxicol Pharmacol. 2014 Sep;165:83-90
(medline /24955954)
CM - Cites: Food Chem Toxicol. 2017 May;103:188-193 (medline /28285934)
CM - Cites: J Chromatogr A. 2002 May 24;957(1):45-57 (medline /12102312)
CM - Cites: Environ Health Perspect. 2009 May;117(5):797-802 (medline
/19479024)
CM - Cites: Springerplus. 2015 Feb 24;4:90 (medline /25763302)
CM -Cites: Food Chem Toxicol. 2016 Oct;96:174-6 (medline /27515866)
CM -Cites: BMC Complement Altern Med. 2016 Jul 22;16:234 (medline /27450510)
CM -Cites: Lancet Oncol. 2015 May;16(5):490-1 (medline /25801782)
CM -Cites: J Steroid Biochem. 1989 Nov;33(5):949-54 (medline /2601340)
CM -Cites: Environ Res. 2017 Jul;156:818-833 (medline /28347490)
CM -Cites: Food Chem Toxicol. 2015 Oct;84:133-53 (medline /26282372)
CM -Cites: Environ Health Perspect. 2006 Dec;114(12):1803-6 (medline
/17185266)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2012;47(9):1249-60 (medline /22540648)
CM - Cites: Toxicology. 2012 Apr 11;294(2-3):94-103 (medline /22365945)
CM - Cites: Environ Toxicol Pharmacol. 2014 Jul;38(1):131-40 (medline
/24930125)
CM - Cites: Int Arch Occup Environ Health. 2009 Mar;82(4):529-37 (medline
/18820944)
CM - Cites: Toxicology. 2015 Jul 3;333:195-205 (medline /25896363)
CM - Cites: Int Arch Occup Environ Health. 1980;47(1):53-60 (medline /7429646)
CM - Cites: Arch Environ Contam Toxicol. 2007 Feb;52(2):217-21 (medline
/17165105)
CM - Cites: Food Chem Toxicol. 2017 Sep;107(Pt A):108-121 (medline /28645870)
CM - Cites: J Biol Chem. 1974 Sep 10;249(17):5364-72 (medline /4153532)
CM - Cites: Chemosphere. 2003 Aug;52(7):1189-97 (medline /12821000)
CM - Cites: Dev Biol. 2014 Apr 1;388(1):22-34 (medline /24530425)
CM - Cites: J Immunol Methods. 1983 Dec 16;65(1-2):55-63 (medline /6606682)
CM - Cites: Toxicol Appl Pharmacol. 1999 Oct 1;160(1):10-20 (medline /10502498)
CM - Cites: Food Chem. 2012 May 1;132(1):502-7 (medline /26434323)
CM - Cites: J Occup Med Toxicol. 2011 Jan 20;6(1):3 (medline /21251308)
CM - Cites: Toxicology. 2013 Nov 16;313(2-3):122-8 (medline /23000283)
CM - Cites: Environ Health Perspect. 1995 Apr;103(4):358-64 (medline /7607136)
CM - Cites: Int J Environ Res Public Health. 2016 Jan 16;13(1):null (medline
/26784217)
CM - Cites: Environ Sci Pollut Res Int. 2012 Nov;19(9):3798-819 (medline
/22864754)
CM - Cites: Int J Mol Sci. 2014 Nov 17;15(11):21253-69 (medline /25407529)
CM - Cites: Mutat Res Genet Toxicol Environ Mutagen. 2015 Dec;794:1-7 (medline
/26653977)
CM - Cites: Toxicology. 2009 Aug 21;262(3):184-91 (medline /19539684)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng.
2006;41(10):2399-428 (medline /17018421)
CM - Cites: Int J Environ Res Public Health. 2016 Feb 26;13(3):null (medline
/26927151)
CM - Cites: Bull Environ Contam Toxicol. 2013 Jun;90(6):742-9 (medline
/23604023)
CM - Cites: J Environ Sci (China). 2017 Mar;53:262-268 (medline /28372750)
CM - Cites: Am J Public Health. 1983 Jan;73(1):32-7 (medline /6847997)
CM - Cites: Regul Toxicol Pharmacol. 2000 Apr;31(2 Pt 1):117-65 (medline
/10854122)
CM - Cites: Reprod Toxicol. 2017 Mar;68:171-190 (medline /27443218)
CM - Cites: FEBS Lett. 1983 Apr 5;154(1):127-33 (medline /11968207)
CM - Cites: Arch Environ Contam Toxicol. 2007 Jul;53(1):126-33 (medline
/17486286)
CM - Cites: Interdiscip Toxicol. 2015 Jun;8(2):55-64 (medline /27486361)
CM - Cites: Environ Sci Eur. 2014;26(1):14 (medline /27752412)
CM - Cites: J Environ Sci Health B. 2014;49(12):971-7 (medline /25310813)
CM - Cites: Toxicol Rep. 2017 Jan 20;4:x-xi (medline /29276687)
DOCNO- medline/29321978

492 - TOXLINE
TI - Combined toxic effect of airborne heavy metals on human lung cell line
A549.
AU - Choi Y
AD - School of Earth Sciences and Environmental Engineering, Gwangju Institute of
Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Korea.
AU - Park K
AD - PM2.5 Research Center, Gwangju Institute of Science and Technology (GIST),
123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Korea.
AU - Kim I
AD - School of Earth Sciences and Environmental Engineering, Gwangju Institute of
Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Korea.
AU - Kim SD
AD - School of Earth Sciences and Environmental Engineering, Gwangju Institute of
Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-gu, Gwangju, 61005, Korea.
sdkim@gist.ac.kr.
SO - Environ Geochem Health. 2018, Feb; 40(1):271-282. [Environmental
geochemistry and health]
AB - Many studies have demonstrated that heavy metals existing as a mixture in
the atmospheric environment cause adverse effects on human health and are
important key factors of cytotoxicity; however, little investigation has
been conducted on a toxicological study of a metal mixture from
atmospheric fine particulate matter. The objective of this study was to
predict the combined effects of heavy metals in aerosol by using in vitro
human cells and obtain a suitable mixture toxicity model. Arsenic, nickel,
and lead were selected for mixtures exposed to A549 human lung cancer
cells. Cell proliferation (WST-1), glutathione (GSH), and interleukin
(IL)-8 inhibition were observed and applied to the prediction models of
mixture toxicity, concentration addition (CA) and independent action (IA).
The total mixture concentrations were set by an IC10-fixed ratio of
individual toxicity to be more realistic for mortality and enzyme
inhibition tests. The results showed that the IA model was statistically
closer to the observed results than the CA model in mortality, indicating
dissimilar modes of action. For the GSH inhibition, the results predicted
by the IA and CA models were highly overestimated relative to mortality.
Meanwhile, the IL-8 results were stable with no significant change in
immune reaction related to inflammation. In conclusion, the IA model is a
rapid prediction model in heavy metals mixtures; mortality, as a total
outcome of cell response, is a good tool for demonstrating the combined
toxicity rather than other biochemical responses.
KW - Concentration addition
KW - Heavy metals
KW - Human cells
KW - Independent action
KW - Mixture toxicity
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180209
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20161125
STAT- In-Process
CM - Cites: Environ Health Perspect. 1997 Sep;105 Suppl 5:1053-60 (medline
/9400700)
CM - Cites: Circulation. 2004 Jan 6;109(1):71-7 (medline /14676145)
CM - Cites: Sci Total Environ. 2012 Feb 15;417-418:45-54 (medline /22257507)
CM - Cites: Free Radic Biol Med. 1996;21(6):783-90 (medline /8902524)
CM - Cites: J Epidemiol Community Health. 2002 Oct;56(10):773-9 (medline
/12239204)
CM - Cites: Sci Total Environ. 2014 Feb 15;472:1001-9 (medline /24345860)
CM - Cites: Eur Respir J. 2000 Mar;15(3):553-9 (medline /10759452)
CM - Cites: Environ Toxicol Chem. 2015 Apr;34(4):821-32 (medline /25475765)
CM - Cites: Environ Health Perspect. 2007 Dec;115(12):1701-3 (medline
/18087586)
CM - Cites: Mutat Res. 2007 Nov-Dec;636(1-3):95-133 (medline /17951105)
CM - Cites: Toxicol In Vitro. 2013 Sep;27(6):1670-8 (medline /23628592)
CM - Cites: Clin Nutr. 2007 Aug;26(4):400-8 (medline /17499891)
CM - Cites: Mycopathologia. 2004 Nov;158(4):441-50 (medline /15630553)
CM - Cites: Environ Toxicol Chem. 2011 Jul;30(7):1697-703 (medline /21538486)
CM - Cites: Toxicol Appl Pharmacol. 1999 May 15;157(1):43-50 (medline
/10329506)
CM - Cites: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008
Oct-Dec;26(4):339-62 (medline /19034792)
CM - Cites: Epidemiology. 2008 Sep;19(5):680-9 (medline /18714438)
CM - Cites: Crit Rev Oncol Hematol. 2002 Apr;42(1):35-56 (medline /11923067)
CM - Cites: Inhal Toxicol. 2005 Apr;17(4-5):243-53 (medline /15804942)
CM - Cites: Integr Environ Assess Manag. 2011 Jan;7(1):99-115 (medline
/21184571)
CM - Cites: J Toxicol Environ Health A. 1998 Aug 7;54(7):529-45 (medline
/9726778)
CM - Cites: Environ Toxicol Chem. 2015 Apr;34(4):799-808 (medline /25336231)
CM - Cites: Environ Sci Pollut Res Int. 2013 Apr;20(4):2569-78 (medline
/22972615)
CM - Cites: Sci Total Environ. 2000 Apr 17;249(1-3):85-101 (medline /10813449)
CM - Cites: Environ Toxicol Chem. 2006 Aug;25(8):2107-13 (medline /16916030)
CM - Cites: Toxicol In Vitro. 2011 Feb;25(1):294-300 (medline /20854890)
CM - Cites: Toxicol Lett. 2003 Jan 31;137(1-2):65-83 (medline /12505433)
CM - Cites: Ecotoxicol Environ Saf. 2008 Mar;69(3):428-36 (medline /17631961)
CM - Cites: Mol Cell Biochem. 2004 Jan;255(1-2):67-78 (medline /14971647)
CM - Cites: Inhal Toxicol. 2005 Dec 1;17(13):775-87 (medline /16195213)
CM - Cites: Ecotoxicol Environ Saf. 1985 Feb;9(1):17-25 (medline /3987587)
DOCNO- medline/27888373

493 - TOXLINE
TI - Transcriptome analysis of silver, palladium, and selenium stresses in
Pantoea sp. IMH.
AU - Liu W
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; University of Chinese Academy of Sciences, Beijing 100049, China.
AU - Wang Y
AD - School of Environmental and Municipal Engineering, Xi'an University of
Architecture and Technology, Xi'an 710055, China.
AU - Jing C
AD - State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research
Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085,
China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic
address: cyjing@rcees.ac.cn.
SO - Chemosphere. 2018, May 29; 208:50-58. [Chemosphere]
AB - Heavy metal contamination is a significant environmental issue. Using
bacteria for removal and reduction of heavy metals is an attractive
alternative owing to its low-cost and eco-friendly properties. However,
the mechanisms of resistance to and reduction of Ag(I), Pd(II), and
Se(IV), especially in the same strain, remain unclear. Here, Pantoea sp.
IMH was examed for its reduction of Ag(I), Pd(II), and Se(IV) to
nanoparticles (NPs), and the molecular mechanism was investigated by
transcriptome analysis. The results revealed that genes encoding binding,
transport, catalytic activity, and metabolism were differentially
expressed in cells exposed to Ag(I), Pd(II), and Se(IV). The same
resistance mechanisms for all metals included multiple stress resistance
protein BhsA and glutathione detoxification metabolism. However, zinc
transport protein and sulfate metabolism played an important role in the
resistance to cationic metals (Ag+ and Pd2+), while the oxalate
transporter and arsenic resistance mechanisms were specifically involved
in the resistance to and reduction of anion (SeO32-). In addition, Ag(I)
was speculated to be reduced to AgNPs by glucose and cytochrome CpxP was
involved in Pd(II) reduction. Our results provided new clues on the
mechanisms of resistance to and reduction of Ag(I), Pd(II), and Se(IV).
KW - Bioreduction
KW - Metal resistance
KW - Nanoparticles
KW - Palladium
KW - Selenium
KW - Silver
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018. Published by Elsevier Ltd.
CITO- NLM
CS - England
FJT - Chemosphere
EDAT- 20180529
STAT- Publisher
DOCNO- medline/29860144

494 - TOXLINE
TI - Potential toxic elements in stream sediments, soils and waters in an
abandoned radium mine (central Portugal).
AU - Antunes IMHR
AD - CERENA Centre, Porto, Portugal. imantunes@dct.uminho.pt.
AU - Neiva AMR
AD - Department of Earth Sciences, University of Coimbra, Coimbra, Portugal.
AU - Albuquerque MTD
AD - Instituto Polit�cnico de Castelo Branco, Castelo Branco, Portugal.
AU - Carvalho PCS
AD - Department of Earth Sciences, University of Coimbra, Coimbra, Portugal.
AU - Santos ACT
AD - Department of Earth Sciences, University of Coimbra, Coimbra, Portugal.
AU - Cunha PP
AD - MARE - Marine and Environmental Sciences Centre, University of Coimbra,
Coimbra, Portugal.
SO - Environ Geochem Health. 2018, Feb; 40(1):521-542. [Environmental
geochemistry and health]
AB - The Alto da V�rzea radium mine (AV) exploited ore and U-bearing
minerals, such as autunite and torbernite. The mine was exploited
underground from 1911 to 1922, closed in 1946 without restoration, and
actually a commercial area is deployed. Stream sediments, soils and water
samples were collected between 2008 and 2009. Stream sediments are mainly
contaminated in As, Th, U and W, which is related to the AV radium mine.
The PTEs, As, Co, Cr, Sr, Th, U, W, Zn, and electrical conductivity
reached the highest values in soils collected inside the mine influence.
Soils are contaminated with As and U and must not be used for any purpose.
Most waters have pH values ranging from 4.3 to 6.8 and are poorly
mineralized (EC = 41-186 &micro;S/cm;
TDS = 33-172 mg/L). Groundwater contains the highest Cu, Cr
and Pb contents. Arsenic occurs predominantly as H2(AsO4)- and H(AsO4)2-.
Waters are saturated in goethite, haematite and some of them also in
lepidocrocite and ferrihydrite, which adsorbs As (V). Lead is divalent in
waters collected during the warm season, being mobile in these waters.
Thorium occurs mainly as Th(OH)3(CO3)-, Th(OH)2(CO3) and Th(OH)2(CO3) 22-
, which increase water Th contents. Uranium occurs predominantly as
UO2CO3, but CaUO2(CO3) 32- and CaUO2(CO3)3 also occur, decreasing its
mobility in water. The waters are contaminated in NO2-, Mn, Cu, As, Pb and
U and must not be used for human consumption and in agricultural
activities. The water contamination is mainly associated with the old
radium mine and human activities. A restoration of the mining area with
PTE monitoring is necessary to avoid a public hazard.
KW - Central Portugal
KW - Contamination
KW - Enrichment factor
KW - Radium mines
KW - Remediation
LA - eng
IS - 1573-2983 (Electronic)
PT - Journal Article
TA - Environ Geochem Health
YR - 2018
DATE- 20180209
CITO- NLM
CS - Netherlands
FJT - Environmental geochemistry and health
EDAT- 20170325
STAT- In-Process
CM - Cites: J Hazard Mater. 2011 Nov 15;195:355-64 (medline /21890271)
CM - Cites: Sci Total Environ. 2013 Jan 1;442:545-52 (medline /23220092)
CM - Cites: Sci Total Environ. 2004 May 25;324(1-3):173-82 (medline /15081704)
CM - Cites: Sci Total Environ. 2012 Aug 1;431:426-35 (medline /22704004)
CM - Cites: Chemosphere. 2006 May;63(5):802-10 (medline /16213554)
CM - Cites: Ecotoxicol Environ Saf. 2016 Nov;133:135-45 (medline /27448230)
CM - Cites: Rev Environ Contam Toxicol. 1996;146:53-89 (medline /8714221)
CM - Cites: Environ Int. 2005 Jan;31(1):53-61 (medline /15607779)
CM - Cites: Water Res. 2012 May 1;46(7):2324-32 (medline /22386884)
CM - Cites: Toxicol Sci. 2011 Oct;123(2):305-32 (medline /21750349)
DOCNO- medline/28343275

495 - TOXLINE
TI - Transformation of roxarsone in the anoxic-oxic process when treating the
livestock wastewater.
AU - Yin Y
AD - School of Chemical Engineering and Energy, Zhengzhou University, 100 Science
Avenue, 450001, PR China.
AU - Wan J
AD - School of Chemical Engineering and Energy, Zhengzhou University, 100 Science
Avenue, 450001, PR China. Electronic address: wanjunfeng@zzu.edu.cn.
AU - Li S
AD - School of Chemical Engineering and Energy, Zhengzhou University, 100 Science
Avenue, 450001, PR China.
AU - Li H
AD - School of Chemical Engineering and Energy, Zhengzhou University, 100 Science
Avenue, 450001, PR China.
AU - Dagot C
AD - GRESE EA 4330, Universit� de Limoges, 123 Avenue Albert Thomas, F-87060
Limoges Cedex, France; INSERM, U1092, Limoges, France.
AU - Wang Y
AD - School of Chemical Engineering and Energy, Zhengzhou University, 100 Science
Avenue, 450001, PR China.
SO - Sci Total Environ. 2018, Mar; 616-617:1235-1241. [The Science of the total
environment]
AB - In order to evaluate the influence of roxarsone (ROX) on the livestock
wastewater treatment, a lab-scale pilot employing an anoxic-oxic (A-O)
process was investigated by adding different concentrations of ROX at
different periods. The mass balance of arsenic (As) in the A-O system was
established through the analysis of As speciation and As migration in the
gas, liquid and solid phases. The results showed that around 80% of total
ROX (initial concentration was 50mgROXL-1) was eliminated in the anoxic
reactor (R1) in which at least about 11% of total ROX was transformed to
inorganic Asv (iAsv) due to the direct breaking of the C-As bond of ROX.
Inorganic AsIII (iAsIII) and arsine (AsH3) were produced in R1, while the
generated iAsIII in the effluent of R1 was almost completely oxidized to
iAsV in the aerobic reactor (R2). However, the concentration of ROX in the
effluent of R2 was almost the same as that in the effluent of R1. After
85days operation, iAsV and residual ROX as the main forms of As were
observed after the A-O process. Furthermore, the mass balance of As at
steady state revealed that around 0.08%, 3.91% and 96.01% of total As was
transformed into gas (biogas), solid (excess sludge) and liquid
(effluent). Additionally, the 16S rRNA analysis demonstrated that the
existence of ROX in livestock wastewater may play a crucial role in the
diversity of bacterial community in the A-O system.
KW - Anoxic-oxic process
KW - As speciation
KW - As transformation
KW - Roxarsone
RN - H5GU9YQL7L
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180509
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20171023
STAT- MEDLINE
DOCNO- medline/29074235

496 - TOXLINE
TI - Controlled burn and immediate mobilization of potentially toxic elements
in soil, from a legacy mine site in Central Victoria, Australia.
AU - Abraham J
AD - School of Applied and Biomedical Sciences, Faculty of Science and Technology,
Federation University Australia, Mount Helen Campus, VIC 3353, Australia.
Electronic address: J.abraham@federation.edu.au.
AU - Dowling K
AD - School of Applied and Biomedical Sciences, Faculty of Science and Technology,
Federation University Australia, Mount Helen Campus, VIC 3353, Australia.
AU - Florentine S
AD - School of Applied and Biomedical Sciences, Faculty of Science and Technology,
Federation University Australia, Mount Helen Campus, VIC 3353, Australia.
SO - Sci Total Environ. 2018, Mar; 616-617:1022-1034. [The Science of the total
environment]
AB - Conducting controlled burns in fire prone areas is an efficient and
economic method for forest management, and provides relief from the
incidence of high severity wild fires and the consequent damage to human
property and ecosystems. However, similar to wild fires, controlled burns
also affect many of the physical and biogeochemical properties of the
forest soil and may facilitate remobilization of potentially toxic
elements (PTEs) sequestered in vegetation and soil organic matter. The
objective of the current study is to investigate the mobilization of PTEs,
in Central Victorian forest soils in Australia after a controlled burn.
Surface soil samples were collected two days before and after the
controlled burn to determine the concentration of PTEs and to examine the
physicochemical properties. Results show that As, Cd, Mn, Ni and Zn
concentrations increased 1.1, 1.6, 1.7, 1.1 and 1.9 times respectively in
the post-burn environment, whereas the concentrations of Hg, Cr and Pb
decreased to 0.7, 0.9 and 0.9 times respectively, highlighting
considerable PTE mobility during and after a controlled burn. Whilst these
results do not identify very strong correlations between physicochemical
properties of soil and PTEs in the pre- and post-burn environments, PTEs
themselves demonstrated very strong and significant correlations. The
mobilization of As, Hg and other toxic elements raise potential health
concerns as the number of controlled burns are projected to increase in
response to climate change. Due to this increased level of PTE release and
remobilization, the use of any kinds of controlled burn must be carefully
considered before being used as a forest management strategy in
mining-affected landscapes which include areas with high PTE
concentrations.
KW - Arsenic and metals
KW - Environmental pollution
KW - Forest fire
KW - Historical mining
KW - Prescribed fire
KW - Soil and water pollution
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180509
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20171106
STAT- MEDLINE
DOCNO- medline/29107365

497 - TOXLINE
TI - Physiologically-based pharmacokinetic and toxicokinetic models for
estimating human exposure to five toxic elements through oral ingestion.
AU - Dede E
AD - Technologies for Sustainable Built Environments (TSBE) Centre, University of
Reading, Reading, RG6 6AF, UK; Institute of Occupational Medicine (IOM), Riccarton,
Edinburgh, EH14 4AP, UK. Electronic address: otidede@yahoo.co.uk.
AU - Tindall MJ
AD - Department of Mathematics and Statistics, University of Reading, Reading, RG6
6AX, UK; The Institute of Cardiovascular and Metabolic Research, University of
Reading, Reading, RG6 6AS, UK. Electronic address: m.tindall@reading.ac.uk.
AU - Cherrie JW
AD - Institute of Occupational Medicine (IOM), Riccarton, Edinburgh, EH14 4AP, UK;
Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt
University, Edinburgh, EH14 4AS, UK. Electronic address: j.cherrie@hw.ac.uk.
AU - Hankin S
AD - Institute of Occupational Medicine (IOM), Riccarton, Edinburgh, EH14 4AP, UK.
Electronic address: Steve.Hankin@iom-world.org.
AU - Collins C
AD - Soil Research Centre, University of Reading, Reading, RG6 6AB, UK. Electronic
address: c.d.collins@reading.ac.uk.
SO - Environ Toxicol Pharmacol. 2018, Jan; 57:104-114. [Environmental
toxicology and pharmacology]
AB - Biological monitoring and physiologically-based pharmacokinetic (PBPK)
modelling are useful complementary tools in quantifying human exposure to
elements in the environment. In this work, we used PBPK models to
determine the optimal time for collecting biological samples in a
longitudinal study to determine if participants who consumed allotment
produce had been exposed to arsenic, cadmium, chromium, nickel or lead.
There are a number of PBPK models for these elements published in the
literature, which vary in size, complexity and application, given the
differences in physiochemical properties of the elements, organs involved
in metabolism and exposure pathways affected. We selected PBPK models from
the literature to simulate the oral ingestion pathway from consumption of
allotment produce. Some models required modification by reducing or
removing selected compartments whilst still maintaining their original
predictability. The performance of the modified models was evaluated by
comparing the predicted urinary and blood elemental levels with
experimental data and other model simulations published in the literature.
Overall, the model predictions were consistent with literature data
(r&#8239; > &#8239;0.7, p&#8239; < &#8239;0.05), and were influential in
predicting when samples should be collected. Our results demonstrate the
use of mathematical modelling in informing and optimising the design of
longitudinal studies.
KW - Allotments
KW - Biomonitoring
KW - Exposure
KW - PBPK model
KW - Toxic elements
LA - eng
IS - 1872-7077 (Electronic)
PT - Journal Article
TA - Environ Toxicol Pharmacol
YR - 2018
DATE- 20180207
CI - Copyright &copy; 2017 The Author(s). Published by Elsevier B.V. All rights
reserved.
CITO- NLM
CS - Netherlands
FJT - Environmental toxicology and pharmacology
EDAT- 20171207
STAT- In-Process
DOCNO- medline/29253785

498 - TOXLINE
TI - Toxic and essential metals in Cyprinus carpio, Carassius gibelio, and
Luciobarbus esocinus tissues from Keban Dam Lake, Pertek, Turkey.
AU - Kaya G
AD - a Health Sciences Faculty, Department of Nutrition and Dietetic , Firat
University , Elazig , Turkey.
AU - Turkoglu S
AD - a Health Sciences Faculty, Department of Nutrition and Dietetic , Firat
University , Elazig , Turkey.
SO - Food Addit Contam Part B Surveill. 2018, Mar; 11(1):1-8. [Food additives &
contaminants. Part B, Surveillance]
AB - In various tissues of Luciobarbus esocinus, Cyprinus carpio, and Carassius
gibelio which were taken from Keban Dam Lake Pertek region's freshwaters,
Turkey in January-February 2016, concentrations of mercury, nickel, lead,
cadmium, arsenic, manganese, chromium, and cobalt were analysed by
inductively coupled plasma-mass spectrometry (ICP-MS) after microwave
digestion. In fish muscle mean chromium concentration (0.614 mg kg-1
in C. carpio muscle) was higher than the maximum limits as set by the
Federal Environmental Protection Agency and World Health Organisation.
Additionally, mean concentration of lead (0.380 mg kg-1 in C. gibelio
muscle) was higher compared to the maximum limit as set by Turkish
Standards. Furthermore, in the assessment of the potential health risk,
estimated weekly and daily intake of all metals were considerably below
permissible tolerable weekly intake (PTWI) and permissible tolerable daily
intake values. As a result, consumption of these fish species from this
region does not pose a problem on human health.
KW - Carassius gibelio
KW - Cyprinus carpio
KW - Heavy metal
KW - Keban Dam Lake
KW - Luciobarbus esocinus
KW - public health risk assessment
LA - eng
IS - 1939-3229 (Electronic)
PT - Journal Article
TA - Food Addit Contam Part B Surveill
YR - 2018
DATE- 20180207
CITO- NLM
CS - England
FJT - Food additives &amp; contaminants. Part B, Surveillance
EDAT- 20170709
STAT- In-Process
DOCNO- medline/28675125

499 - TOXLINE
TI - Comparison among ultrasonic, electrical apparatus, and toxic chemicals for
vestibular lesion in mice.
AU - Yamaoka Y
AD - Department of Physiology, Gifu University Graduate School of Medicine, Gifu,
Japan.
AU - Abe C
AD - Department of Physiology, Gifu University Graduate School of Medicine, Gifu,
Japan. Electronic address: chikara@gifu-u.ac.jp.
AU - Morita H
AD - Department of Physiology, Gifu University Graduate School of Medicine, Gifu,
Japan.
SO - J Neurosci Methods. 2018, Feb 01; 295:58-67. [Journal of neuroscience
methods]
AB - BACKGROUND: The vestibular lesion (VL) is required to examine the
physiological function of the vestibular system in animals. Toxic
chemicals or electrical apparatus have been used for the VL, however, they
are not ideal as they have low specificity, and can result in unintended
damage, and systemic toxic effect.
AB - NEW METHOD: Localized vibration-induced VL, using an ultrasonicator, is
expected to overcome the problems associated with chemical and electrical
lesions. Thus, we examined the effect of the ultrasonication on the VL
from the aspects of both the physiological function and histology in the
present study.
AB - RESULTS: and Comparison with Existing Method(s) Complete VL, which was
evaluated by deterioration of swimming skills, righting reflex, and body
stability, was induced using an ultrasonicator or electrical apparatus.
Histological evaluation shows that hair cell layers in the saccule and
utricle were completely destroyed in both methods Furthermore, significant
drop in body mass was observed in VL. However, abscess at the cranial base
was observed in VL induced by the electrical apparatus in ICR mice.
Complete chemically-induced VL was observed in C57BL/6J but not ICR mice,
and systemic leakage of the toxic chemicals (arsenic) was not detectable
even 1day after surgery.
AB - CONCLUSIONS: Compared to the electrical apparatus, the ultrasonicator is
useful for inducing VL in ICR and C57BL/6J mice, as it results in less
non-specific damage. Toxic chemicals can be used for inducing VL in
C57BL/6J mice; however, this method does not ensure complete disruption of
the hair cells in the saccule and utricle.
KW - Labyrinthectomy
KW - Saccule
KW - Space medicine
KW - Utricle
KW - Vestibular ganglion
LA - eng
IS - 1872-678X (Electronic)
PT - Journal Article
TA - J Neurosci Methods
YR - 2018
DATE- 20180206
CI - Copyright &copy; 2017 The Author(s). Published by Elsevier B.V. All rights
reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of neuroscience methods
EDAT- 20171202
STAT- In-Data-Review
DOCNO- medline/29198950

500 - TOXLINE
TI - An analysis of human exposure to trace elements from deliberate soil
ingestion and associated health risks.
AU - Ngole-Jeme VM
AD - Department of Environmental Sciences, School of Environmental Sciences,
College of Agriculture and Environmental Sciences, University of South Africa,
Florida 1710, Roodepoort, South Africa.
AU - Ekosse GE
AD - Directorate of Research and Innovation, University of Venda, Private Bag
X5050, Thohoyandou, Limpopo Province 0950, South Africa.
AU - Songca SP
AD - Office of the Deputy Vice Chancellor, Teaching and Learning, University of
Zululand, Private Bag X1001, KwaDlangezwa 3886, KwaZulu-Natal, South Africa.
SO - J Expo Sci Environ Epidemiol. 2018, Jan; 28(1):55-63. [Journal of exposure
science & environmental epidemiology]
AB - Fifty-seven samples of soils commonly ingested in South Africa, Swaziland,
Democratic Republic of Congo (DRC), and Togo were analyzed for the
concentrations of arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr),
copper (Cu), lead (Pb), manganese (Mn), nickel (Ni), and zinc (Zn) and
their bioaccessibility in the human gastrointestinal tract.
Bioaccessibility values were used to calculate daily intake, and hazard
quotient of each trace element, and chronic hazard index (CHI) of each
sample. Carcinogenic risk associated with As and Ni exposure were also
calculated. Mean pseudo-total concentrations of trace elements in all
samples were 7.2, 83.3, 77.1, 15.4, 28.6, 24.9, 56.1, 2.8, and
26.5&thinsp;mg/kg for As, Cr, Mn, Co, Ni, Cu, Zn, Cd, and Pb,
respectively. Percent bioaccessibility of Pb (13-49%) and Zn (38-56%) were
highest among trace elements studied. Average daily intake values were
lower than their respective reference doses for ell elements except for Pb
in selected samples. Samples from DRC presented the highest health risks
associated with trace element exposure with most of the samples having CHI
values between 0.5 and 1.0. Some samples had higher than unacceptable
values of carcinogenic risk associated with As and Ni exposure. Results
indicate low trace element exposure risk from ingesting most of the soil
samples.
LA - eng
IS - 1559-064X (Electronic)
PT - Comparative Study
PT - Journal Article
TA - J Expo Sci Environ Epidemiol
YR - 2018
DATE- 20180507
CITO- NLM
CS - United States
CSET- IM
FJT - Journal of exposure science &amp; environmental epidemiology
EDAT- 20161207
STAT- MEDLINE
CM - Cites: Environ Int. 2012 Dec 1;50:47-55 (medline /23073482)
CM - Cites: Am J Trop Med Hyg. 2009 Jan;80(1):36-43 (medline /19141837)
CM - Cites: Am J Trop Med Hyg. 2015 Jun;92(6):1117-24 (medline /25918214)
CM - Cites: Environ Geochem Health. 2010 Dec;32(6):517-27 (medline /20473633)
CM - Cites: Int J Environ Res Public Health. 2015 Jul 31;12(8):8933-55 (medline
/26264010)
CM - Cites: Environ Pollut. 2008 Mar;152(1):60-72 (medline /17601641)
CM - Cites: Arch Environ Contam Toxicol. 2003 Apr;44(3):281-7 (medline
/12712286)
CM - Cites: Environ Sci Pollut Res Int. 2013 May;20(5):3140-8 (medline
/23054795)
CM - Cites: J Hazard Mater. 2007 Feb 9;140(1-2):165-72 (medline /16973266)
CM - Cites: S Afr Med J. 2014 Jun 19;104(8):568-73 (medline /25213850)
CM - Cites: J Environ Sci Health A Tox Hazard Subst Environ Eng. 2010
Aug;45(10):1264-74 (medline /20635294)
CM - Cites: Trans R Soc Trop Med Hyg. 2010 Dec;104(12):787-95 (medline
/20889178)
CM - Cites: J Exp Biol. 2004 Jan;207(Pt 2):319-24 (medline /14668315)
CM - Cites: Chemosphere. 2013 Apr;91(4):455-61 (medline /23273879)
CM - Cites: J Toxicol Environ Health A. 2007 Oct;70(19):1700-11 (medline
/17763089)
CM - Cites: Appl Environ Microbiol. 2012 Sep;78(18):6397-404 (medline
/22798364)
CM - Cites: Environ Health. 2010 Dec 23;9:79 (medline /21182763)
CM - Cites: Anal Chim Acta. 2008 Aug 1;622(1-2):126-32 (medline /18602543)
CM - Cites: Gut. 1996 Nov;39(5):625-8 (medline /9026473)
CM - Cites: Environ Geochem Health. 2016 Feb;38(1):233-41 (medline /25980559)
CM - Cites: Trop Med Int Health. 1998 Jul;3(7):529-34 (medline /9705186)
CM - Cites: Sci Total Environ. 2010 Jan 15;408(4):726-33 (medline /19926116)
CM - Cites: PLoS One. 2013;8(1):e53304 (medline /23308189)
CM - Cites: Trans R Soc Trop Med Hyg. 1998 Sep-Oct;92(5):549-53 (medline
/9861377)
CM - Cites: Int J Environ Health Res. 2014;24(1):18-30 (medline /23574040)
CM - Cites: Med Anthropol. 1992 Jan;13(4):337-51 (medline /1545692)
CM - Cites: J Assoc Physicians India. 2005 Mar;53:205-7 (medline /15926605)
CM - Cites: PLoS One. 2012;7(11):e46793 (medline /23152752)
CM - Cites: Environ Pollut. 2011 May;159(5):1215-21 (medline /21345560)
CM - Cites: J Environ Monit. 2012 Mar;14(3):791-803 (medline /22237700)
CM - Cites: Environ Geochem Health. 2015 Apr;37(2):363-75 (medline /25416852)
CM - Cites: Am J Clin Nutr. 1968 Dec;21(12):1384-93 (medline /4881679)
DOCNO- medline/27924816

501 - TOXLINE
TI - Metal- and metalloid-containing drugs for the treatment of trypanosomatid
diseases.
AU - Colotti G
AD - CNR-Institute of Molecular Biology and Pathology, c/o Department of
Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Roma,
Italy.
AU - Fiorillo A
AD - CNR-Institute of Molecular Biology and Pathology, c/o Department of
Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Roma,
Italy.
AU - Ilari A
AD - CNR-Institute of Molecular Biology and Pathology, c/o Department of
Biochemical Sciences, Sapienza University of Rome, P.le A. Moro 5, 00185 Roma,
Italy, andrea.ilari@uniroma1.it.
SO - Front Biosci (Landmark Ed). 2018, Jan 01; 23:954-966. [Frontiers in
bioscience (Landmark edition)]
AB - The trypanosomatid-induced diseases are considered as neglected, because
the countries where they kill people are not important markets for western
big pharmaceutical companies. However, recently some effort has been made
to translate the use of already known drugs to neglected infectious
disease. Although many metals are essential to life, many disorders
affecting metal homeostasis and bioavailability are responsible for
several human diseases. Metals can be toxic even at very low
concentrations and semimetals are classified as toxic and dangerous for
the environment. However, metal- and metalloid-based therapeutic drugs
have existed for centuries. Some of them, as antimony and arsenic
compounds, are still the first line drugs used for the treatment of
leishmaniasis and trypanosomiases in developing countries. Other metal
complexes (as those of Ag, Pt, Pd and Au), already present in the market
for cancer therapies or to cure bacterial infection or for
anti-inflammatory treatments, have been proposed also against the
vector-borne infections caused by trypanosomatids. The use of novel
approaches based on nanotechnologies, allowing selective targeting, may
represent a promising strategy to decrease the toxicity of these drugs.
LA - eng
IS - 1093-4715 (Electronic)
PT - Journal Article
PT - Review
TA - Front Biosci (Landmark Ed)
YR - 2018
DATE- 20180601
CITO- NLM
CS - United States
CSET- IM
FJT - Frontiers in bioscience (Landmark edition)
EDAT- 20180101
STAT- MEDLINE
DOCNO- medline/28930584

502 - TOXLINE
TI - Identifying principles for effective messages about chemicals in cigarette
smoke.
AU - Noar SM
AD - School of Media and Journalism, University of North Carolina at Chapel Hill,
United States; Lineberger Comprehensive Cancer Center, University of North Carolina
at Chapel Hill, United States. Electronic address: noar@email.unc.edu.
AU - Kelley DE
AD - School of Media and Journalism, University of North Carolina at Chapel Hill,
United States.
AU - Boynton MH
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina at Chapel Hill, United States; Lineberger
Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United
States.
AU - Morgan JC
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina at Chapel Hill, United States.
AU - Hall MG
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina at Chapel Hill, United States; Lineberger
Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United
States.
AU - Mendel JR
AD - Lineberger Comprehensive Cancer Center, University of North Carolina at
Chapel Hill, United States.
AU - Ribisl KM
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina at Chapel Hill, United States; Lineberger
Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United
States.
AU - Brewer NT
AD - Department of Health Behavior, Gillings School of Global Public Health,
University of North Carolina at Chapel Hill, United States; Lineberger
Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United
States.
SO - Prev Med. 2018, Jan; 106:31-37. [Preventive medicine]
AB - US law requires the Food and Drug Administration (FDA) to disclose
information on harmful and potentially harmful chemicals in cigarette
smoke (i.e., constituents) to the public. To inform this effort, we sought
to identify principles for creating constituent messages that effectively
discourage smoking. Participants were an online convenience sample of 1148
US smokers ages 18+. We developed a library of 76 messages about
constituents only and constituents plus contextualizing information (i.e.,
toxic products that also contain the chemical, health effects, or both).
We randomized smokers to receive 1 message from each of 7 message panels
in a mixed between-/within-subjects experiment. Participants rated each
message on perceived message effectiveness. Results indicated that smokers
perceived messages about arsenic, formaldehyde, lead, uranium, and ammonia
as more effective than messages about nitrosamines. Messages that
contained information on toxic products, health effects, or both received
higher effectiveness ratings than constituent-only messages. Among
constituent-only messages, those that referenced multiple constituents
received higher effectiveness ratings than those with fewer constituents.
We conclude that chemical messages may have more impact if they pair known
constituents with toxic product or health effect information. These
message principles can be used to inform studies examining the impact of
constituent messages on smoking beliefs and behavior.
KW - Chemical
KW - Constituent
KW - Disclosure
KW - Experiment
KW - Messaging
KW - Smoking
KW - Tobacco
LA - eng
IS - 1096-0260 (Electronic)
PT - Journal Article
TA - Prev Med
YR - 2018
DATE- 20180201
CI - Copyright &copy; 2017 Elsevier Inc. All rights reserved.
CITO- NLM
CS - United States
FJT - Preventive medicine
EDAT- 20170908
STAT- In-Data-Review
CM - Cites: Health Commun. 2017 Aug;32(8):931-938 (medline /27435919)
CM - Cites: Health Educ Res. 2015 Feb;30(1):35-45 (medline /24848554)
CM - Cites: Tob Control. 2006 Jun;15 Suppl 3:iii19-25 (medline /16754942)
CM - Cites: Tob Control. 2016 Sep;26(5):592-599 (medline /27924009)
CM - Cites: Patient Educ Couns. 1999 Sep;38(1):33-42 (medline /14528569)
CM - Cites: Annu Rev Psychol. 2011;62:583-619 (medline /19575624)
CM - Cites: Ann Behav Med. 2016 Oct;50(5):736-750 (medline /27333895)
CM - Cites: Nicotine Tob Res. 2002;4 Suppl 2:S147-55 (medline /12573176)
CM - Cites: Soc Sci Med. 2016 Sep;164:118-129 (medline /27423739)
CM - Cites: Tob Control. 2003 Dec;12(4):424-30 (medline /14660781)
CM - Cites: Nicotine Tob Res. 2016 Jul;18(7):1566-74 (medline /26681775)
CM - Cites: JAMA. 2004 Mar 10;291(10):1238-45 (medline /15010446)
CM - Cites: Nicotine Tob Res. 2016 Aug;18(8):1749-56 (medline /27170707)
CM - Cites: Tob Control. 2014 Sep;23(5):412-8 (medline /23604496)
CM - Cites: Perspect Psychol Sci. 2011 Jan;6(1):3-5 (medline /26162106)
CM - Cites: Tob Control. 2016 Mar;25(2):153-9 (medline /25564282)
CM - Cites: Nicotine Tob Res. 2017 May 17;:null (medline /28521063)
CM - Cites: Nicotine Tob Res. 2004 Dec;6 Suppl 3:S333-40 (medline /15799596)
CM - Cites: J Behav Med. 2017 Aug;40(4):553-564 (medline /28224264)
CM - Cites: Ann Intern Med. 1997 Dec 1;127(11):966-72 (medline /9412301)
CM - Cites: Nicotine Tob Res. 2014 Mar;16(3):343-50 (medline /24151139)
CM - Cites: Public Health. 2012 Jul;126(7):613-9 (medline /22609086)
CM - Cites: Nicotine Tob Res. 2012 Jan;14(1):18-28 (medline /21324834)
CM - Cites: Med Decis Making. 2001 Jan-Feb;21(1):37-44 (medline /11206945)
CM - Cites: Tob Control. 2011 Sep;20(5):327-37 (medline /21606180)
CM - Cites: J Behav Med. 2017 Apr;40(2):352-359 (medline /27663553)
CM - Cites: J Theor Biol. 2012 Apr 21;299:172-9 (medline /21402081)
CM - Cites: Tob Control. 2014 Sep;23(5):385-8 (medline /23481906)
CM - Cites: Int J Environ Res Public Health. 2011 Feb;8(2):613-28 (medline
/21556207)
CM - Cites: Acc Chem Res. 2016 Jan 19;49(1):106-14 (medline /26678241)
DOCNO- medline/28890353

503 - TOXLINE
TI - Assessment of Electrolytes and Metals Profile of the Faro Lake (Capo
Peloro Lagoon, Sicily, Italy) and Its Impact on Mytilus galloprovincialis.
AU - Capillo G
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166,
S.Agata-Messina, Italy.
AU - Silvestro S
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166,
S.Agata-Messina, Italy.
AU - Sanfilippo M
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166,
S.Agata-Messina, Italy.
AU - Fiorino E
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166,
S.Agata-Messina, Italy.
AU - Giangrosso G
AD - Istituto Zooprofilattico Sperimentale della Sicilia, via Gino Marinuzzi, 3,
90129, Palermo, Italy.
AU - Ferrantelli V
AD - Istituto Zooprofilattico Sperimentale della Sicilia, via Gino Marinuzzi, 3,
90129, Palermo, Italy.
AU - Vazzana I
AD - Istituto Zooprofilattico Sperimentale della Sicilia, via Gino Marinuzzi, 3,
90129, Palermo, Italy.
AU - Faggio C
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166,
S.Agata-Messina, Italy.
SO - Chem Biodivers. 2018, May; 15(5):e1800044. [Chemistry & biodiversity]
AB - Faro Lake is a coastal meromictic lagoon with singular characteristics in
the Mediterranean (Messina, Sicily - Italy). It is part of the Natural
Oriented Reserve of Capo Peloro (38&deg; 15' 57&Prime; N; 15&deg; 37'
50&Prime; E). In this area, traditional mollusc farming activity persists,
producing 'autochthonous' mussels. This study reports of the Mytilus
galloprovincialis haemolymph chemical profile and water variables
determination of 1 year-lasted survey (April 2016 - March 2017). The
determinations of electrolytes (Na+ , Cl- , K+ , Ca2+ , Mg2+ , P
inorganic) and heavy metals in both Faro lake water and haemolymph have
been carried out. Heavy metals are elements with high density and are
quite toxic in low concentrations, such as Aluminum (Al), Arsenic (As),
Cobalt (Co), Chrome (Cr), Copper (Cu), Iron (Fe), Magnesium (Mg),
Manganese (Mn), Lead (Pb), Tin (Sn), Zinc (Zn). Heavy metals toxicity
depends, principally, on bioaccumulation processes. M. galloprovincialis
is a good bio-indicator, ideal for assess levels of environmental
pollution thanks to its biological, ecological and physiological
characteristics. The results of this study showed a typical fluctuation
range in haemolymph and water parameters, related to the water ones;
chemical-physical parameters affected the ions (electrolytes and metals)
levels in some period of the year. The study reports the interactions
between biotic (Mytilus galloprovincialis) and abiotic (water parameters)
components of Faro Lake, and creates reference data for further future
study on the same area or on similar ones.
KW - Mytilus galloprovincialis
KW - Capo Peloro Lagoon
KW - electrolytes
KW - haemolymph
KW - heavy metals
LA - eng
IS - 1612-1880 (Electronic)
PT - Journal Article
TA - Chem Biodivers
YR - 2018
DATE- 20180611
CI - &copy; 2018 Wiley-VHCA AG, Zurich, Switzerland.
CITO- NLM
CS - Switzerland
CSET- IM
FJT - Chemistry &amp; biodiversity
EDAT- 20180429
STAT- MEDLINE
DOCNO- medline/29520986

504 - TOXLINE
TI - Mercury Toxicity Following Unauthorized Siddha Medicine Intake - A
Mimicker of Acquired Neuromyotonia - Report of 32 Cases.
AU - Gnanashanmugam G
AD - Department of Neurology, PSGIMSR, Coimbatore, Tamil Nadu, India.
AU - Balakrishnan R
AD - Department of Neurology, PSGIMSR, Coimbatore, Tamil Nadu, India.
AU - Somasundaram SP
AD - Department of Neurology, PSGIMSR, Coimbatore, Tamil Nadu, India.
AU - Parimalam N
AD - Department of Neurology, PSGIMSR, Coimbatore, Tamil Nadu, India.
AU - Rajmohan P
AD - Department of Neurology, PSGIMSR, Coimbatore, Tamil Nadu, India.
AU - Pranesh MB
AD - Department of Neurology, PSGIMSR, Coimbatore, Tamil Nadu, India.
SO - Ann Indian Acad Neurol. 2018 Jan-Mar; 21(1):49-56. [Annals of Indian
Academy of Neurology]
AB - Context: Mercury is used extensively in the preparation of Siddha
medicines, after purification. In this study, we present 32 patients of
mercury toxicity following unauthorized Siddha medicine intake who
mimicked neuromyotonia clinically. We analyzed the clinical features of
these patients, the role of autoimmunity in etiopathology, and compared it
with acquired neuromyotonia.
AB - Subjects and Methods: This is a retrospective study to analyze inpatients
in a tertiary care center, admitted with mercury toxicity following Siddha
medicine intake from August 2012 to October 2016. We analyzed the clinical
features, laboratory data including mercury, arsenic and lead levels in
blood, and serum voltage-gated potassium channels (VGKC)-CASPR2 Ab in
selected patients.
AB - Results: Thirty-two patients who had high blood mercury levels following
Siddha medicine intake were included in the study. All patients (100%) had
severe intractable neuropathic pain predominantly involving lower limbs.
Twenty-six (81.25%) patients had fasciculations and myokymia. Fifteen
patients (46.86%) had autonomic dysfunction (postural hypotension and
resting tachycardia). Nine (28.12%) patients had encephalopathic features
such as dullness, apathy, drowsiness, or delirium. Anti-VGKC Ab was
positive in 12 patients with myokymia. All the patients in the study
consumed Siddha medicines obtained from unauthorized dealers.
AB - Conclusions: Mercury toxicity following Siddha medicine intake closely
mimics acquired neuromyotonia; severe intolerable neuropathic pain is the
hallmark feature; Positive VGKC-CASPR2 antibody in some patients must be
due to triggered autoimmunity secondary to mercury toxicity due to Siddha
medicine intake. The government should establish licensing system to
prevent distribution of unauthorized Siddha medicines.
COI - There are no conflicts of interest.
KW - Mercury toxicity
KW - Siddha medicine toxicity
KW - myokymia
KW - neuromyotonia
KW - voltage gated potassium channels-CASPR2 Ab
LA - eng
IS - 0972-2327 (Print)
PT - Journal Article
TA - Ann Indian Acad Neurol
YR - 2018
DATE- 20180507
CITO- NLM
CS - India
FJT - Annals of Indian Academy of Neurology
STAT- PubMed-not-MEDLINE
CM - Cites: J Neurol Sci. 2000 Dec 1;181(1-2):38-43 (medline /11099710)
CM - Cites: Trans Soc Occup Med. 1970 Apr;20(2):54-9 passim (medline /5432201)
CM - Cites: Eur Neurol. 2014;72(3-4):218-22 (medline /25227723)
CM - Cites: J Neurol Neurosurg Psychiatry. 1961 Nov;24(4):319-25 (medline
/21610902)
CM - Cites: J Anal At Spectrom. 2010;25(8):1275-1282 (medline /21643429)
CM - Cites: Sci Total Environ. 2013 Jun 1;454-455:9-15 (medline /23538135)
CM - Cites: Neurol India. 2006 Dec;54(4):382-6 (medline /17114847)
CM - Cites: Brain. 1993 Apr;116 ( Pt 2):453-69 (medline /8461975)
CM - Cites: Indian J Nephrol. 2013 Jul;23(4):301-3 (medline /23960350)
CM - Cites: Muscle Nerve. 2000 May;23(5):655-7 (medline /10797387)
CM - Cites: Acta Neurol Scand. 1977 Apr;55(4):273-88 (medline /857572)
CM - Cites: J Neurol. 1984;231(5):244-9 (medline /6440953)
CM - Cites: Pediatrics. 2000 Mar;105(3):E34 (medline /10699136)
CM - Cites: Lancet. 1991 Jul 13;338(8759):75-7 (medline /1676468)
CM - Cites: Brain. 2001 Dec;124(Pt 12):2417-26 (medline /11701596)
CM - Cites: Am J Med Sci. 2000 Apr;319(4):209-16 (medline /10768605)
CM - Cites: Ann Neurol. 1995 Nov;38(5):714-22 (medline /7486862)
DOCNO- medline/29720798

505 - TOXLINE
TI - Trace Element Removal in Distributed Drinking Water Treatment Systems by
Cathodic H2O2 Production and UV Photolysis.
AU - Barazesh JM
AD - Carollo Engineers, Inc. , Costa Mesa, California 92626, United States.
AU - Prasse C
AD - Department of Civil and Environmental Engineering, University of California
at Berkeley , Berkeley, California 94720 United States.
AU - Wenk J
AD - Department of Chemical Engineering and Water Innovation &amp; Research
Centre, University of Bath , Claverton Down, Bath, BA2 7AY United Kingdom.
AU - Berg S
AD - Environmental Chemistry &amp; Technology Program, University of Wisconsin-
Madison , Madison, Wisconsin 53706 United States.
AU - Remucal CK
AD - Department of Civil and Environmental Engineering, University of Wisconsin-
Madison , Madison, Wisconsin 53706 United States.
AU - Sedlak DL
AD - Department of Civil and Environmental Engineering, University of California
at Berkeley , Berkeley, California 94720 United States.
SO - Environ Sci Technol. 2018, Jan 02; 52(1):195-204. [Environmental science &
technology]
AB - As water scarcity intensifies, point-of-use and point-of-entry treatment
may provide a means of exploiting locally available water resources that
are currently considered to be unsafe for human consumption. Among the
different classes of drinking water contaminants, toxic trace elements
(e.g., arsenic and lead) pose substantial operational challenges for
distributed drinking water treatment systems. Removal of toxic trace
elements via adsorption onto iron oxides is an inexpensive and robust
treatment method; however, the presence of metal-complexing ligands
associated with natural organic matter (NOM) often prevents the formation
of iron precipitates at the relatively low concentrations of dissolved
iron typically present in natural water sources, thereby requiring the
addition of iron which complicates the treatment process and results in a
need to dispose of relatively large amounts of accumulated solids. A
point-of-use treatment device consisting of a cathodic cell that produced
hydrogen peroxide (H2O2) followed by an ultraviolet (UV) irradiation
chamber was used to decrease colloid stabilization and metal-complexing
capacity of NOM present in groundwater. Exposure to UV light altered NOM,
converting &sim;6 &mu;M of iron oxides into settable forms that
removed between 0.5 and 1 &mu;M of arsenic (As), lead (Pb), and copper
(Cu) from solution via adsorption. After treatment, changes in NOM
consistent with the loss of iron-complexing carboxylate ligands were
observed, including decreases in UV absorbance and shifts in the molecular
composition of NOM to higher H/C and lower O/C ratios. Chronoamperometric
experiments conducted in synthetic groundwater revealed that the presence
of Ca2+ and Mg2+ inhibited intramolecular charge-transfer within
photoexcited NOM, leading to substantially increased removal of iron and
trace elements.
LA - eng
IS - 1520-5851 (Electronic)
PT - Journal Article
TA - Environ Sci Technol
YR - 2018
DATE- 20180127
CITO- NLM
CS - United States
FJT - Environmental science &amp; technology
EDAT- 20171214
STAT- In-Data-Review
CM - Cites: Environ Sci Technol. 2002 Feb 15;36(4):617-24 (medline /11878375)
CM - Cites: Environ Sci Technol. 2015 Aug 18;49(16):9945-53 (medline /26172118)
CM - Cites: Environ Sci Technol. 2009 Feb 1;43(3):597-603 (medline /19244989)
CM - Cites: Anal Chem. 2007 Feb 15;79(4):1758-63 (medline /17297983)
CM - Cites: Environ Sci Technol. 2002 Apr 1;36(7):1467-76 (medline /11999052)
CM - Cites: Environ Sci Technol. 2013 Oct 15;47(20):11726-33 (medline
/24011169)
CM - Cites: Environ Sci Technol. 2016 Aug 2;50(15):8093-102 (medline /27377760)
CM - Cites: Science. 2000 Jul 14;289(5477):284-8 (medline /10894773)
CM - Cites: Environ Sci Technol. 2003 Mar 1;37(5):958-71 (medline /12666927)
CM - Cites: Environ Sci Technol. 2017 Sep 5;51(17 ):9624-9632 (medline
/28719191)
CM - Cites: Environ Sci Technol. 2013 Oct 1;47(19):11147-56 (medline /23978074)
CM - Cites: Environ Sci Technol. 2016 Dec 6;50(23 ):12532-12547 (medline
/27736067)
CM - Cites: Environ Sci Technol. 2009 Apr 1;43(7):2262-8 (medline /19452872)
CM - Cites: Environ Sci Technol. 2015 Aug 4;49(15):9133-42 (medline /26132788)
CM - Cites: Environ Sci Technol. 2017 Feb 21;51(4):2113-2123 (medline
/28121132)
CM - Cites: Anal Chem. 2006 Jul 1;78(13):4363-73 (medline /16808443)
CM - Cites: Environ Sci Technol. 2016 Sep 6;50(17 ):9736-45 (medline /27482620)
CM - Cites: Science. 2016 May 20;352(6288):928-33 (medline /27199414)
CM - Cites: Anal Chem. 2002 Sep 1;74(17):4397-409 (medline /12236348)
CM - Cites: Environ Sci Technol. 2016 Feb 2;50(3):1200-8 (medline /26790005)
CM -Cites: J Hazard Mater. 2007 Apr 2;142(1-2):1-53 (medline /17324507)
CM -Cites: Environ Sci Technol. 2013 Oct 1;47(19):10721-6 (medline /23650975)
CM -Cites: Environ Sci Technol. 2015 Jun 16;49(12):7391-9 (medline /26039560)
CM -Cites: Environ Sci Technol. 2012 Jan 17;46(2):986-94 (medline /22132945)
CM -Cites: Environ Sci Technol. 2016 Dec 20;50(24):13502-13510 (medline
/27993045)
CM - Cites: Photochem Photobiol. 2006 Nov-Dec;82(6):1505-16 (medline /16968114)
CM - Cites: Water Res. 2011 Jul;45(13):3811-22 (medline /21645916)
CM - Cites: Environ Sci Technol. 2013 Oct 1;47(19):10987-94 (medline /23952218)
CM - Cites: Chemphyschem. 2006 Apr 10;7(4):942-54 (medline /16521156)
CM - Cites: Environ Sci Technol. 2012 Nov 6;46(21):12038-45 (medline /22978489)
CM - Cites: Environ Sci Technol. 2003 Nov 1;37(21):4877-86 (medline /14620813)
CM - Cites: Biochem J. 2001 Aug 1;357(Pt 3):893-8 (medline /11463363)
CM - Cites: Environ Sci Technol. 2011 Apr 15;45(8):3196-201 (medline /21405118)
CM - Cites: Environ Sci Process Impacts. 2014 Apr;16(4):654-71 (medline
/24509887)
CM - Cites: Environ Sci Technol. 2014 Oct 21;48(20):11794-802 (medline
/25222517)
CM - Cites: Environ Sci Technol. 2016 Oct 4;50(19):10406-10412 (medline
/27631570)
CM - Cites: Environ Sci Technol. 2001 May 15;35(10):2114-21 (medline /11393995)
CM - Cites: Environ Sci Technol. 2003 Sep 15;37(18):4182-9 (medline /14524451)
CM - Cites: Environ Sci Technol. 2011 Feb 15;45(4):1334-40 (medline /21271693)
CM - Cites: Science. 2006 Aug 25;313(5790):1072-7 (medline /16931750)
CM - Cites: Environ Sci Technol. 2014;48(5):2688-96 (medline /24383955)
CM - Cites: Free Radic Biol Med. 1987;3(3):169-80 (medline /3666518)
CM - Cites: Environ Sci Technol. 2016 Apr 5;50(7):3545-53 (medline /26910810)
CM - Cites: Environ Sci Technol. 2012 May 1;46(9):4916-25 (medline /22463073)
CM - Cites: Sci Total Environ. 2014 Aug 1;488-489:539-46 (medline /24355249)
CM - Cites: Environ Sci Technol. 2011 Apr 1;45(7):2584-90 (medline /21405071)
CM - Cites: Water Res. 2017 Oct 1;122:42-52 (medline /28591660)
DOCNO- medline/29240414

506 - TOXLINE
TI - Prehistoric polydactylism: Biological evidence and rock art representation
from the Atacama Desert in northern Chile.
AU - Standen VG
AD - Departamento de Antropolog�a, Universidad de Tarapac�, Arica, Chile.
Electronic address: vstanden@uta.cl.
AU - Santoro CM
AD - Instituto de Alta Investigaci�n, Universidad de Tarapac�, Arica, Chile.
Electronic address: csantoro@uta.cl.
AU - Arriaza B
AD - Instituto de Alta Investigaci�n, Universidad de Tarapac�, Arica, Chile.
Electronic address: barriaza@uta.cl.
AU - Valenzuela D
AD - Departamento de Antropolog�a, Universidad de Tarapac�, Arica, Chile.
Electronic address: dvalenzu@uta.cl.
AU - Coleman D
AD - Department of Geological Sciences, University of North Carolina, USA.
Electronic address: dcoleman@unc.edu.
AU - Monsalve S
AD - Departamento de Antropolog�a, Universidad de Tarapac�, Arica, Chile.
SO - Int J Paleopathol. 2018, Jun 01; 22:54-65. [International journal of
paleopathology]
AB - A review of the bioarchaeological collections from the site Morro de Arica
in northern Chile allowed the identification of two cases of human
polydactyly. Both cases are from the Chinchorro culture, hunters, fishers,
and gatherers with a maritime orientation who inhabited the coast of the
Atacama Desert (9000-3400&#8239;BP). Additionally, the analyses of 75 rock
art sites in the area, from the Formative to Late Intermediate Periods
(3000-550&#8239;BP), allowed the identification of hands and feet with six
digits. Given the bioarchaeological record of polydactyly, it is highly
probable that the rock art images were based on real individuals with
polydactyly. However, the Sr chemical signal in a juvenile with
polydactyly is the same as the Sr chemical signal in the rest of the
individuals buried in the same site, proving that all the individuals were
born and lived on the coast. We discuss the idea that, although these
anomalies could have been the result of genetic mutations, endogamy and
exposition to ecotoxic environments could also be at play within the
Chinchorro groups.
KW - Chinchorro mummies
KW - Chronic arsenic poisoning
KW - Endogamy
KW - Polydactyly
KW - Strontium isotopes
LA - eng
IS - 1879-9825 (Electronic)
PT - Journal Article
TA - Int J Paleopathol
YR - 2018
DATE- 20180619
CI - Copyright &copy; 2018. Published by Elsevier Inc.
CITO- NLM
CS - Netherlands
FJT - International journal of paleopathology
EDAT- 20180601
STAT- Publisher
DOCNO- medline/29864653

507 - TOXLINE
TI - Whole blood and hair trace elements and minerals in children living in
metal-polluted area near copper smelter in Karabash, Chelyabinsk region,
Russia.
AU - Skalny AV
AD - RUDN University, Miklukho-Maklai str. 6, Moscow, 117198, Russia.
AU - Zhukovskaya EV
AD - Federal Scientific Clinical Centre of Pediatric Hematology Oncology
Immunology named after Dvitry Rogachev, Samory Mashela St., 1, 117997, Moscow,
Russia.
AU - Kireeva GN
AD - Chelyabinsk Regional Pediatric Hospital, Bluchera St. 42a, Chelyabinsk,
454076, Russia.
AU - Skalnaya MG
AD - RUDN University, Miklukho-Maklai str. 6, Moscow, 117198, Russia.
AU - Grabeklis AR
AD - Russian Society of Trace Elements in Medicine, ANO "Centre for Biotic
Medicine", Zemlyanoi Val St., 46, 105064, Moscow, Russia.
AU - Radysh IV
AD - RUDN University, Miklukho-Maklai str. 6, Moscow, 117198, Russia.
AU - Shakieva RA
AD - Kazakh Academy of Nutrition, Klochkov St., 66, Almaty, 050000, Republic of
Kazakhstan.
AU - Nikonorov AA
AD - Department of Biochemistry, Orenburg State Medical University, Sovetskaya
St., 6, Orenburg, 460000, Russia.
AU - Tinkov AA
AD - Department of Biochemistry, Orenburg State Medical University, Sovetskaya
St., 6, Orenburg, 460000, Russia. tinkov.a.a@gmail.com.
SO - Environ Sci Pollut Res Int. 2018, Jan; 25(3):2014-2020. [Environmental
science and pollution research international]
AB - The primary aim of the study is assessment of hair and whole blood trace
element and mineral levels in children living in a polluted area near a
copper smelter (Karabash) and two control locations (Varna, Tomino) using
inductively coupled plasma mass spectrometry. The obtained data indicates
that both blood and hair As, Pb, and Fe levels in children living in
Karabash significantly exceeded the control values. Whole blood levels of
copper in children living in Varna exceeded that in Tomino
(p = 0.155) and Karabash (p < 0.001) by 16 %.
Oppositely, hair concentration of Cu was maximal in children from
Karabash. Blood Ca and Mg content in children from Varna exceeded the
respective values from Tomino and Karabash by 32 %
(p = 0.021) and 42 % (p < 0.001), and
19 % (p < 0.001) and 9 % (p < 0.001),
respectively. Similar differences were observed in hair mineral content.
Oppositely, children living in Tomino and Karabash were characterized by
10 (p = 0.002) and 23 % (p < 0.001) higher
levels of blood phosphorus. At the same time, hair P content was maximal
in a polluted area. Therefore, children living in a polluted area near a
copper smelter had significantly higher values of heavy metals and
decreased Mg and Ca content in biosamples. It is supposed that adverse
health effects in persons living near a copper smelter may be associated
not only with toxic metal overexposure but also with altered mineral
homeostasis.
KW - Antagonism
KW - Arsenic
KW - Calcium
KW - Copper-smelter
KW - Magnesium
KW - Metal pollution
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180121
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20161019
STAT- In-Process
CM - Cites: Environ Pollut. 2009 Nov;157(11):3078-82 (medline /19573961)
CM - Cites: Lancet. 2006 Dec 16;368(9553):2167-78 (medline /17174709)
CM - Cites: Sci Total Environ. 2000 Jan 31;246(1):61-7 (medline /10682377)
CM - Cites: Environ Pollut. 2014 May;188:159-65 (medline /24598788)
CM - Cites: Am J Clin Nutr. 2009 Jun;89(6):2009S-2024S (medline /19420093)
CM - Cites: Proc Biol Sci. 2004 Feb 7;271(1536):221-6 (medline /15058430)
CM - Cites: Anal Chem. 1982 Sep;54(11):1844-9 (medline /7149260)
CM - Cites: Sci Total Environ. 2005 Jan 20;337(1-3):175-82 (medline /15626388)
CM - Cites: Sci Total Environ. 2012 Feb 15;417-418:138-47 (medline /22248854)
CM - Cites: J Nutr. 1977 Oct;107(10):1779-85 (medline /903822)
CM - Cites: Neurotoxicology. 2009 Jul;30(4):564-71 (medline /19635390)
CM - Cites: Mol Cell Biochem. 2004 Jan;255(1-2):47-55 (medline /14971645)
CM - Cites: Environ Health Perspect. 2000 Jun;108 Suppl 3:443-8 (medline
/10852843)
CM - Cites: Bull Environ Contam Toxicol. 1990 Oct;45(4):478-85 (medline
/2279110)
CM -Cites: Ecotoxicol Environ Saf. 2003 Sep;56(1):93-103 (medline /12915143)
CM -Cites: Br Med Bull. 2003;68:167-82 (medline /14757716)
CM -Cites: Talanta. 2002 Aug 16;58(1):201-35 (medline /18968746)
CM -Cites: Int J Environ Health Res. 2014 Aug;24(4):304-19 (medline /24044870)
CM -Cites: Biol Trace Elem Res. 2014 Oct;161(1):13-9 (medline /25048403)
CM -Cites: Environ Res. 2006 May;101(1):1-10 (medline /16171795)
CM -Cites: Annu Rev Nutr. 1997;17:37-50 (medline /9240918)
CM -Cites: Mol Aspects Med. 2005 Aug-Oct;26(4-5):235-44 (medline /16125765)
CM -Cites: Environ Monit Assess. 2004 Nov;98(1-3):235-59 (medline /15473539)
CM -Cites: Environ Health Perspect. 2002 Feb;110(2):197-204 (medline
/11836150)
CM - Cites: Sci Total Environ. 1999 May 7;229(1-2):121-4 (medline /10418166)
CM - Cites: Environ Pollut. 2008 Jan;151(2):362-7 (medline /17646040)
CM - Cites: Sci Total Environ. 2007 Nov 15;387(1-3):96-104 (medline /17765948)
CM - Cites: Environ Res. 1993 Aug;62(2):242-50 (medline /8344231)
DOCNO- medline/27761855

508 - TOXLINE
TI - Residential radon and cancer mortality in Galicia, Spain.
AU - L�pez-Abente G
AD - Cancer and Environmental Epidemiology Unit, National Epidemiology Center,
Carlos III, Institute of Health, Avda. Monforte de Lemos 5, 28029 Madrid, Spain;
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en
Epidemiolog�a y Salud P�blica - CIBERESP), Spain. Electronic address:
glabente@isciii.es.
AU - N��ez O
AD - Cancer and Environmental Epidemiology Unit, National Epidemiology Center,
Carlos III, Institute of Health, Avda. Monforte de Lemos 5, 28029 Madrid, Spain;
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en
Epidemiolog�a y Salud P�blica - CIBERESP), Spain.
AU - Fern�ndez-Navarro P
AD - Cancer and Environmental Epidemiology Unit, National Epidemiology Center,
Carlos III, Institute of Health, Avda. Monforte de Lemos 5, 28029 Madrid, Spain;
Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en
Epidemiolog�a y Salud P�blica - CIBERESP), Spain.
AU - Barros-Dios JM
AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBER
en Epidemiolog�a y Salud P�blica - CIBERESP), Spain; Department of Preventive
Medicine and Public Health, University of Santiago de Compostela, School of
Medicine, San Francisco Street, 15782 Santiago de Compostela, Galicia, Spain;
Preventive Medicine Unit, Santiago de Compostela Clinic University Hospital,
Santiago de Compostela, Galicia, Spain.
AU - Mart�n-M�ndez I
AD - Department of Geochemistry and Mineral Resources, Spanish Geological and
Mining Institute (Instituto Geol�gico y Minero de Espa�a/IGME), R�os Rosas, 23,
28003 Madrid, Spain.
AU - Bel-Lan A
AD - Department of Geochemistry and Mineral Resources, Spanish Geological and
Mining Institute (Instituto Geol�gico y Minero de Espa�a/IGME), R�os Rosas, 23,
28003 Madrid, Spain.
AU - Locutura J
AD - Department of Geochemistry and Mineral Resources, Spanish Geological and
Mining Institute (Instituto Geol�gico y Minero de Espa�a/IGME), R�os Rosas, 23,
28003 Madrid, Spain.
AU - Quind�s L
AD - RADON Group, Faculty of Medicine, University of Cantabria, c/Cardenal Herrera
Oria s/n, 39011 Santander, Cantabria, Spain.
AU - Sainz C
AD - RADON Group, Faculty of Medicine, University of Cantabria, c/Cardenal Herrera
Oria s/n, 39011 Santander, Cantabria, Spain.
AU - Ruano-Ravina A
AD - Consortium for Biomedical Research in Epidemiology and Public Health (CIBER
en Epidemiolog�a y Salud P�blica - CIBERESP), Spain; Department of Preventive
Medicine and Public Health, University of Santiago de Compostela, School of
Medicine, San Francisco Street, 15782 Santiago de Compostela, Galicia, Spain;
Preventive Medicine Unit, Santiago de Compostela Clinic University Hospital,
Santiago de Compostela, Galicia, Spain.
SO - Sci Total Environ. 2018, Jan 01; 610-611:1125-1132. [The Science of the
total environment]
AB - Residential radon exposure is a serious public health concern, and as such
appears in the recommendations of European Code Against Cancer. The
objective of this study was to assess the association between residential
radon levels and mortality due to different types of cancer, using
misaligned data analysis techniques. Mortality data (observed cases) for
each of the 313 Galician municipalities were drawn from the records of the
National Statistics Institute for the study period (1999-2008). Expected
cases were computed using Galician mortality rates for 14 types of
malignant tumors as reference, with a total of 56,385 deaths due to the
tumors analyzed. The effect estimates of indoor radon (3371 sampling
points) were adjusted for sociodemographic variables, altitude, and
arsenic topsoil levels (1069 sampling points), using
spatial/geostatistical models fitted with stochastic partial differential
equations and integrated nested Laplace approximations. These models are
capable of processing misaligned data. The results showed a statistical
association between indoor radon and lung, stomach and brain cancer in
women in Galicia. Apart from lung cancer (relative risk (RR)=1.09), in
which a twofold increase in radon exposure led to a 9% rise in mortality,
the association was particularly relevant in stomach (RR=1.17) and brain
cancer (RR=1.28). Further analytical epidemiologic studies are needed to
confirm these results, and an assessment should be made of the
advisability of implementing interventions targeting such exposure in
higher-risk areas.
KW - Cancer mortality
KW - Geochemistry
KW - Indoor radon
KW - Medical geology
KW - Misaligned data
KW - Residential radon
KW - Soil composition
KW - Spatial data analysis
RN - Q74S4N8N1G
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180504
CI - Copyright &copy; 2017 The Authors. Published by Elsevier B.V. All rights
reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20170830
STAT- MEDLINE
DOCNO- medline/28847132

509 - TOXLINE
TI -[Acute promyelocytic leukaemia].
AU -T�stesen M
AD -michael.tostesen@gmail.com.
AU -&Oslash;sterg�rd LSG
AD -michael.tostesen@gmail.com.
AU -Kjeldsen E
AD -michael.tostesen@gmail.com.
AU -Stentoft J
AD -michael.tostesen@gmail.com.
AU -N�rgaard JM
AD -michael.tostesen@gmail.com.
SO -Ugeskr Laeger. 2018, 01 15. [Ugeskrift for laeger]
AB -Acute promyelocytic leukaemia has changed from being a highly fatal to a
highly curable disease. Over time, key discoveries have identified the
genetic and molecular abnormalities, which cause the disease. First choice
of treatment has now changed from all-trans retinoic acid (ATRA) and
chemotherapy to a chemo-free combination of arsenic trixoide and ATRA.
This new regimen has shown equal responses and overall cure rates compared
with the previous standard of care containing conventional chemotherapy,
but with much lower toxicity. This will pave the way for better and easier
treatment for elderly and frail patients.
LA - dan
IS - 1603-6824 (Electronic)
PT - English Abstract
PT - Journal Article
TA - Ugeskr Laeger
YR - 2018
DATE- 20180119
CITO- NLM
CS - Denmark
FJT - Ugeskrift for laeger
STAT- In-Process
DOCNO- medline/29336301

510 - TOXLINE
TI - Single and combined metal contamination in coastal environments in China:
current status and potential ecological risk evaluation.
AU - Manzoor R
AD - Key Laboratory of Marine Environment and Ecology, Ministry of Education,
Ocean University of China, Qingdao, 266100, People's Republic of China.
AU - Zhang T
AD - Key Laboratory of Marine Environment and Ecology, Ministry of Education,
Ocean University of China, Qingdao, 266100, People's Republic of China.
AU - Zhang X
AD - Key Laboratory of Marine Environment and Ecology, Ministry of Education,
Ocean University of China, Qingdao, 266100, People's Republic of China.
AU - Wang M
AD - Key Laboratory of Marine Environment and Ecology, Ministry of Education,
Ocean University of China, Qingdao, 266100, People's Republic of China.
yihan@ouc.edu.cn.
AU - Pan JF
AD - College of Environmental Science and Engineering, Ocean University of China,
Qingdao, 266100, People's Republic of China. jfpan@ouc.edu.cn.
AU - Wang Z
AD - College of Environmental Science and Engineering, Ocean University of China,
Qingdao, 266100, People's Republic of China.
AU - Zhang B
AD - College of Environmental Science and Engineering, Ocean University of China,
Qingdao, 266100, People's Republic of China.
SO - Environ Sci Pollut Res Int. 2018, Jan; 25(2):1044-1054. [Environmental
science and pollution research international]
AB - With the development of industrialization and urbanization, metal and
metalloid pollution is one of the most serious environmental problems in
China. Current contamination status of metals and metalloid and their
potential ecological risks along China's coasts were reviewed in the
present paper by a comprehensive study on metal contents in marine waters
and sediments in the past few decades. The priority metals/metalloid
cadmium (Cd), mercury (Hg), chromium (Cr), lead (Pb), and arsenic (As),
which were the target elements of the designated project "Comprehensive
Prevention and Control of Heavy Metal Pollution" issued by the Chinese
government in 2011, were selected considering their high toxicity,
persistence, and prevalent existence in coastal environment. Commonly used
environmental quality evaluation methods for single and combined metals
were compared, and we accordingly suggest the comprehensive approach of
joint utilization of the Enrichment Factor and Effect Range Median
combined with Pollution Load Index and Mean Effect Range Median Quotient
(EEPME); this battery of guidelines may provide consistent,
internationally comparable, and accurate understanding of the environment
pollution status of combined metals/metalloid and their potential
ecological risk.
KW - China
KW - Coastal environment
KW - Combined contamination
KW - Environmental quality evaluation
KW - Heavy metal
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180116
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
EDAT- 20171110
STAT- In-Process
CM - Cites: Mar Pollut Bull. 2015 Jun 15;95(1):419-26 (medline /25840866)
CM - Cites: Chemosphere. 2011 Oct;85(6):1080-7 (medline /21862100)
CM - Cites: Environ Monit Assess. 2011 Apr;175(1-4):175-91 (medline /20535551)
CM - Cites: Mar Pollut Bull. 2013 Nov 15;76(1-2):7-15 (medline /24084375)
CM - Cites: Sci Total Environ. 2012 Apr 1;421-422:3-16 (medline /21470665)
CM - Cites: Environ Toxicol Chem. 2013 Apr;32(4):831-40 (medline /23354695)
CM - Cites: Mar Pollut Bull. 2003 Jan;46(1):123-31 (medline /12535978)
CM - Cites: Huan Jing Ke Xue. 2008 May;29(5):1153-62 (medline /18624172)
CM - Cites: Environ Monit Assess. 2010 Feb;161(1-4):349-58 (medline /19205912)
CM - Cites: Mar Environ Res. 2009 Oct;68(4):178-87 (medline /19586658)
CM - Cites: Mar Pollut Bull. 2009 Jan;58(1):134-44 (medline /18990413)
CM - Cites: Ambio. 2010 Jul-Sep;39(5-6):367-75 (medline /21053720)
CM - Cites: J Environ Sci (China). 2010;22(1):23-31 (medline /20397383)
CM - Cites: Anal Sci. 2006 Aug;22(8):1055-63 (medline /16896242)
CM - Cites: Mar Pollut Bull. 2008 Dec;56(12):2082-8 (medline /18945455)
CM - Cites: Mar Pollut Bull. 2010 Aug;60(8):1364-71 (medline /20705535)
CM - Cites: Mar Pollut Bull. 2012 Aug;64(8):1529-36 (medline /22704147)
CM - Cites: Environ Monit Assess. 2009 Oct;157(1-4):515-28 (medline /18839324)
CM - Cites: Mar Pollut Bull. 2013 Jul 15;72(1):281-8 (medline /23465622)
CM - Cites: Chemosphere. 2003 Sep;52(9):1647-58 (medline /12867199)
CM - Cites: Environ Sci Technol. 1995 Jun 1;29(6):1495-503 (medline /22276869)
CM - Cites: Sci Rep. 2014 Aug 08;4:5995 (medline /25104138)
CM - Cites: J Environ Sci (China). 2008;20(6):664-9 (medline /18763559)
CM - Cites: Mar Pollut Bull. 2014 Dec 15;89(1-2):427-434 (medline /25455380)
CM - Cites: Integr Environ Assess Manag. 2012 Oct;8(4):610-24 (medline
/22275113)
CM - Cites: Chemosphere. 2013 Nov;93(9):1957-64 (medline /23880240)
CM - Cites: Environ Sci Technol. 2013 Jul 2;47(13):7483-9 (medline /23745797)
CM - Cites: Chemosphere. 2016 Jul;155:564-572 (medline /27155472)
DOCNO- medline/29127640

511 - TOXLINE
TI - Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W.
Li and their potential application of preventing oxidative insults in
human lung epithelial cells.
AU - Zhou MX
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Li GH
AD - Department of Pharmacy, Jinan Maternity and Child Care Hospital, Jinan, PR
China.
AU - Sun B
AD - National Glycoengineering Research Center, Shandong University, Jinan 250012,
PR China.
AU - Xu YW
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Li AL
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Li YR
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Ren DM
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Wang XN
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Wen XS
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Lou HX
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China.
AU - Shen T
AD - Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences,
Shandong University, Jinan, PR China. Electronic address: shentao@sdu.edu.cn.
SO - Redox Biol. 2018, Apr; 14:154-163. [Redox biology]
AB - Human lung tissue, directly exposed to the environmental oxidants and
toxicants, is apt to be harmed to bring about acute or chronic oxidative
insults. The nuclear factor erythroid 2-related factor 2 (Nrf2) represents
a central cellular defense mechanism, and is a target for developing
agents against oxidative insult-induced human lung diseases. Our previous
study found that the EtOH extract of Cinnamomum chartophyllum protected
human bronchial epithelial cells against oxidative insults via Nrf2
activation. In this study, a systemic phytochemical investigation of the
aerial parts of C. chartophyllum led to the isolation of thirty chemical
constituents, which were further evaluated for their Nrf2 inducing
potential using NAD(P)H: quinone reductase (QR) assay. Among these
purified constituents, a sesquiterpenoid bearing &alpha;,
&beta;-unsaturated ketone group, 3S-(+)-9-oxonerolidol (NLD), and a
diphenyl sharing phenolic groups, 3, 3', 4, 4'-tetrahydroxydiphenyl (THD)
significantly activated Nrf2 and its downstream genes, NAD(P)H quinone
oxidoreductase 1 (NQO-1), and &gamma;-glutamyl cysteine synthetase
(&gamma;-GCS), and enhanced the nuclear translocation and stabilization of
Nrf2 in human lung epithelial cells. Importantly, NLD and THD had no
toxicities under the Nrf2 inducing doses. THD also demonstrated a
potential of interrupting Nrf2-Keap1 protein-protein interaction (PPI).
Furthermore, NLD and THD protected human lung epithelial cells against
sodium arsenite [As(III)]-induced cytotoxicity. Taken together, we
conclude that NLD and THD are two novel Nrf2 activators with potential
application of preventing acute and chronic oxidative insults in human
lung tissue.
KW - Arsenic
KW - Cinnamomum chartophyllum
KW - Nrf2 activator
KW - Oxidative insult
LA - eng
IS - 2213-2317 (Electronic)
PT - Journal Article
TA - Redox Biol
YR - 2018
DATE- 20171202
CI - Copyright &copy; 2017 The Authors. Published by Elsevier B.V. All rights
reserved.
CITO- NLM
CS - Netherlands
FJT - Redox biology
EDAT- 20170914
STAT- In-Process
CM - Cites: Free Radic Biol Med. 2006 Jan 15;40(2):183-92 (medline /16413400)
CM - Cites: Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1529-38 (medline
/24859871)
CM - Cites: Bioorg Med Chem Lett. 2013 May 15;23 (10 ):3039-43 (medline
/23562243)
CM - Cites: Antioxid Redox Signal. 2013 Nov 10;19(14 ):1647-61 (medline
/23394605)
CM - Cites: Environ Health Perspect. 2009 Nov;117(11):1718-23 (medline
/20049123)
CM - Cites: Org Biomol Chem. 2013 Jun 7;11(21):3553-7 (medline /23615671)
CM - Cites: Diabetes. 2011 Nov;60(11):3055-66 (medline /22025779)
CM - Cites: Annu Rev Pharmacol Toxicol. 2013;53:401-26 (medline /23294312)
CM - Cites: Genes Cells. 2005 Dec;10(12):1113-25 (medline /16324149)
CM - Cites: Toxicol Appl Pharmacol. 2012 Dec 15;265(3):292-9 (medline
/22975029)
CM - Cites: J Biochem Mol Toxicol. 2013 Feb;27(2):99-105 (medline /23188707)
CM - Cites: Redox Biol. 2017 Aug;12 :311-324 (medline /28285192)
CM - Cites: Mini Rev Med Chem. 2017;17 (1):33-43 (medline /26791737)
CM - Cites: J Appl Toxicol. 2011 Mar;31(2):95-107 (medline /21321970)
CM - Cites: Respir Med. 2009 Sep;103(9):1245-56 (medline /19464864)
CM - Cites: Toxicol Appl Pharmacol. 2010 Apr 1;244(1):43-56 (medline /19646463)
CM - Cites: Eur J Pharmacol. 2001 Oct 19;429(1-3):195-207 (medline /11698041)
CM - Cites: J Pediatr (Rio J). 2014 Sep-Oct;90(5):493-9 (medline /24878007)
CM - Cites: Annu Rev Pharmacol Toxicol. 1996;36:83-106 (medline /8725383)
CM - Cites: Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L478-88
(medline /18162601)
CM - Cites: J Med Chem. 2014 Mar 27;57(6):2736-45 (medline /24512214)
CM - Cites: Arch Toxicol. 2011 Apr;85(4):273-84 (medline /21369766)
CM - Cites: BMC Complement Altern Med. 2016 Sep 13;16:360 (medline /27623767)
CM - Cites: Planta Med. 2014 Mar;80(5):426-34 (medline /24585092)
CM - Cites: Environ Health Perspect. 2008 Sep;116(9):1154-61 (medline
/18795156)
CM - Cites: Eur Respir J. 2006 Feb;27(2):397-412 (medline /16452599)
CM - Cites: Environ Res. 2016 May;147:537-55 (medline /26891939)
CM - Cites: CA Cancer J Clin. 2015 Mar;65(2):87-108 (medline /25651787)
CM - Cites: Med Res Rev. 2012 Jul;32(4):687-726 (medline /22549716)
CM - Cites: Zhongguo Zhong Yao Za Zhi. 2015 Sep;40(18):3598-602 (medline
/26983207)
CM - Cites: Biochem Pharmacol. 2012 Apr 15;83(8):1033-40 (medline /22209713)
CM - Cites: Free Radic Biol Med. 2012 Jan 15;52(2):444-51 (medline /22107959)
CM - Cites: Antioxid Redox Signal. 2015 Sep 10;23(8):651-64 (medline /25891177)
CM - Cites: J Natl Cancer Inst. 2007 Jun 20;99(12):920-8 (medline /17565158)
CM - Cites: Trends Mol Med. 2011 Jul;17(7):363-71 (medline /21459041)
CM - Cites: Oncol Rep. 2013 Feb;29(2):676-84 (medline /23229154)
CM - Cites: Pharmacol Res. 2008 Nov-Dec;58(5-6):262-70 (medline /18838122)
CM - Cites: Curr Opin Chem Biol. 2011 Feb;15(1):162-73 (medline /21195017)
CM - Cites: Genes Dev. 2013 Oct 15;27(20):2179-91 (medline /24142871)
CM - Cites: J Med Chem. 2016 Apr 28;59(8):3991-4006 (medline /27031670)
CM - Cites: Arch Toxicol. 2013 Feb;87(2):383-96 (medline /22914984)
CM - Cites: Free Radic Biol Med. 2008 Mar 1;44(5):907-17 (medline /18166164)
CM - Cites: Free Radic Res. 2012 Oct;46(10 ):1220-9 (medline /22762311)
CM - Cites: Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):341-57 (medline
/9279209)
CM - Cites: Nat Prod Rep. 2014 Jan;31(1):109-39 (medline /24292194)
CM - Cites: Chem Res Toxicol. 2012 Sep 17;25(9):1805-24 (medline /22686525)
DOCNO- medline/28942193

512 - TOXLINE
TI - Influence of diet in urinary levels of metals in a biomonitoring study of
a child population of the Valencian region (Spain).
AU - P�rez R
AD - Foundation for the Promotion of Health and Biomedical Research in the
Valencian Region, FISABIO-Public Health, 21 Avenida Catalunya, 46020 Valencia,
Spain; Public Health Laboratory of Valencia, 21 Avenida Catalunya, 46020 Valencia,
Spain.
AU - Dom�nech E
AD - Institute of Food Engineering for Development (IUIAD), Department of Food
Technology (DTA), Universitat Polit�cnica de Val�ncia, Camino de Vera, 16, 46022
Valencia, Spain.
AU - Conchado A
AD - Department of Applied Statistics and Operational Research and Quality,
Universitat Polit�cnica de Val�ncia, Camino de Vera s/n, 46022 Valencia, Spain;
EDEM - Business School Marina Real Juan Carlos I, Spain.
AU - Sanchez A
AD - Public Health Laboratory of Alicante, 6 Plaza de Espa�a, 03010 Alicante,
Spain.
AU - Coscoll� C
AD - Foundation for the Promotion of Health and Biomedical Research in the
Valencian Region, FISABIO-Public Health, 21 Avenida Catalunya, 46020 Valencia,
Spain; Public Health Laboratory of Valencia, 21 Avenida Catalunya, 46020 Valencia,
Spain.
AU - Yus� V
AD - Foundation for the Promotion of Health and Biomedical Research in the
Valencian Region, FISABIO-Public Health, 21 Avenida Catalunya, 46020 Valencia,
Spain; Public Health Laboratory of Valencia, 21 Avenida Catalunya, 46020 Valencia,
Spain; Analytical Chemistry Department, University of Valencia, 50 Doctor Moliner,
46100 Burjassot, Spain. Electronic address: yusa_vic@gva.es.
SO - Sci Total Environ. 2018, Mar 15; 618:1647-1657. [The Science of the total
environment]
AB - Pollution by trace elements and its possible effect on organisms has
become a worldwide concern due to the increasing presence of trace
elements in the environment and especially in the food chain. Exposure to
chemicals has traditionally been measured using environmental samples,
however, human biomonitoring brings a different perspective, in which all
sources and exposure pathways are integrated. The objective of this paper
is to discern the possible relationship between children's diet and the
metals found in children urine. With this aim in mind, a total of 120
voluntaries participated in a diet survey carried out in a school-aged
population (age 6-11) from the Valencian region. In addition, twenty trace
elements were analysed in children urine (arsenic, antimony, barium,
beryllium, caesium, cadmium, cobalt, copper, lead, manganese, mercury,
molybdenum, nickel, platinum, selenium, thallium, thorium, uranium,
vanadium and zinc). Results permitted to compare metal levels in urine
with metal levels of other biomonitoring studies to conclude that values,
including ours, were similar in most studies. On the other hand, children
who ate more vegetables had the highest values in cadmium, copper,
molybdenum, antimony, thallium, vanadium, and zinc, while those who ate
more fish reached higher values in mercury. Finally, children who ate more
cereals and baked products had higher values in total arsenic.
KW - Biomonitoring
KW - Children
KW - Metals
KW - Urine
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180503
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - The Science of the total environment
EDAT- 20171018
STAT- MEDLINE
DOCNO- medline/29054627

513 - TOXLINE
TI - Release of Particulate Iron Sulfide during Shale-Fluid Interaction.
AU - Kreisserman Y
AD - Institute of Earth Sciences, The Hebrew University , Jerusalem 91904, Israel.
AU - Emmanuel S
AD - Institute of Earth Sciences, The Hebrew University , Jerusalem 91904, Israel.
SO - Environ Sci Technol. 2018, Jan 16; 52(2):638-643. [Environmental science &
technology]
AB - During hydraulic fracturing, a technique often used to extract
hydrocarbons from shales, large volumes of water are injected into the
subsurface. Although the injected fluid typically contains various
reagents, it can become further contaminated by interaction with minerals
present in the rocks. Pyrite, which is common in organic-rich shales, is a
potential source of toxic elements, including arsenic and lead, and it is
generally thought that for these elements to become mobilized, pyrite must
first dissolve. Here, we use atomic force microscopy and environmental
scanning electron microscopy to show that during fluid-rock interaction,
the dissolution of carbonate minerals in Eagle Ford shale leads to the
physical detachment, and mobilization, of embedded pyrite grains. In
experiments carried out over a range of pH, salinity, and temperature we
found that in all cases pyrite particles became detached from the shale
surfaces. On average, the amount of pyrite detached was equivalent to 6.5
&times; 10-11 mol m-2 s-1, which is over an order of magnitude greater
than the rate of pyrite oxidation expected under similar conditions. This
result suggests that mechanical detachment of pyrite grains could be an
important pathway for the mobilization of arsenic in hydraulic fracturing
operations and in groundwater systems containing shales.
LA - eng
IS - 1520-5851 (Electronic)
PT - Journal Article
TA - Environ Sci Technol
YR - 2018
DATE- 20180116
CITO- NLM
CS - United States
FJT - Environmental science &amp; technology
EDAT- 20171228
STAT- In-Data-Review
DOCNO- medline/29227634

514 - TOXLINE
TI - Consumption of water from ex-mining ponds in Klang Valley and Melaka,
Malaysia: A health risk study.
AU - Koki IB
AD - Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur,
50603, Malaysia; Department of Chemistry, Northwest University Kano, PMB, 3220,
Kano, Nigeria.
AU - Low KH
AD - Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur,
50603, Malaysia. Electronic address: lowkayin@um.edu.my.
AU - Juahir H
AD - East Coast Environmental Research Institute (ESERI), University Sultan Zainal
Abidin, Kuala Terengganu, Malaysia.
AU - Abdul Zali M
AD - Environmental Health Division, Department of Chemistry Malaysia, Jalan
Sultan, 46661, Petaling Jaya, Selangor, Malaysia.
AU - Azid A
AD - East Coast Environmental Research Institute (ESERI), University Sultan Zainal
Abidin, Kuala Terengganu, Malaysia.
AU - Zain SM
AD - Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur,
50603, Malaysia.
SO - Chemosphere. 2018, Mar; 195:641-652. [Chemosphere]
AB - Evaluation of health risks due to heavy metals exposure via drinking water
from ex-mining ponds in Klang Valley and Melaka has been conducted.
Measurements of As, Cd, Pb, Mn, Fe, Na, Mg, Ca, and dissolved oxygen, pH,
electrical conductivity, total dissolved solid, ammoniacal nitrogen, total
suspended solid, biological oxygen demand were collected from 12 ex-mining
ponds and 9 non-ex-mining lakes. Exploratory analysis identified As, Cd,
and Pb as the most representative water quality parameters in the studied
areas. The metal exposures were simulated using Monte Carlo methods and
the associated health risks were estimated at 95th and 99th percentile.
The results revealed that As was the major risk factor which might have
originated from the previous mining activity. For Klang Valley, adults
that ingested water from those ponds are at both non-carcinogenic and
carcinogenic risks, while children are vulnerable to non-carcinogenic
risk; for Melaka, only children are vulnerable to As complications.
However, dermal exposure showed no potential health consequences on both
adult and children groups.
KW - Arsenic
KW - Chemometrics
KW - Metals
KW - Monte Carlo
KW - Pollution
KW - Water quality
RN - 059QF0KO0R
LA - eng
IS - 1879-1298 (Electronic)
PT - Journal Article
TA - Chemosphere
YR - 2018
DATE- 20180503
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
CSET- IM
FJT - Chemosphere
EDAT- 20171219
STAT- MEDLINE
DOCNO- medline/29287272

515 - TOXLINE
TI - [Laser treatment of basal cell carcinoma].
AU - Salavastru C
AD - "Carol Davila" Universit�t f�r Medizin und Pharmazie, Bukarest, Rum�nien.
galati1968@yahoo.com.
AU - Tiplica GS
AD - 2. Dermatologische Klinik, Colentina Clinical Hospital, Bukarest, Rum�nien.
AU - Fritz K
AD - Haut�rzte und Laserzentrum, Landau (Pfalz), Deutschland.
SO - Hautarzt. 2018, Jan; 69(1):10-16. [Der Hautarzt; Zeitschrift fur
Dermatologie, Venerologie, und verwandte Gebiete]
AB - With a clear increase in the incidence and a continuously earlier onset,
the main risk factors for the development of basal cell carcinoma are
still exposure to sunlight, fair skin, immunosuppression, carcinogens such
as arsenic, chronic irritations and certain genodermatoses. Treatment
options for localized resectionable basal cell carcinoma include
micrographically controlled surgery, simple excision, curettage, laser
ablation, cryosurgery, imiquimod, 5&#8209;fluorouracil, photodynamic
treatment and radiotherapy. Non-surgical treatment options are more suited
for cases in which surgical procedures lead to disfigurement or functional
impairments or for patients with a high surgical risk. Laser treatment,
ablative and non-ablative as monotherapy or in combination can represent a
meaningful treatment option in selected cases. In recent years there has
been an increase in knowledge about the indications and effects of laser
treatment of basal cell carcinoma; nevertheless, further studies with a
high level of evidence are necessary.
KW - Ablative laser treatment
KW - Basal cell carcinoma
KW - Combination treatment
KW - Non-ablative laser treatment
KW - Patient satisfaction
LA - ger
IS - 1432-1173 (Electronic)
PT - English Abstract
PT - Journal Article
PT - Review
TA - Hautarzt
TT - Lasertherapie des Basalzellkarzinoms.
YR - 2018
DATE- 20180115
CITO- NLM
CS - Germany
FJT - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte
Gebiete
STAT- In-Process
CM - Cites: JAMA Dermatol. 2014 Sep;150(9):994-8 (medline /24827701)
CM - Cites: Lasers Surg Med. 1988;8(3):264-75 (medline /3134586)
CM - Cites: Dermatol Res Pract. 2014;2014:931657 (medline /25371667)
CM - Cites: Lasers Surg Med. 2009 Aug;41(6):417-22 (medline /19588534)
CM - Cites: Dermatol Surg. 2002 Mar;28(3):287-90 (medline /11896785)
CM - Cites: Br J Dermatol. 2014 Apr;170(4):809-15 (medline /24283541)
CM - Cites: J Am Acad Dermatol. 2015 Mar;72(3):558-60 (medline /25687314)
CM - Cites: J Invest Dermatol. 2012 Jun;132(6):1591-6 (medline /22377757)
CM - Cites: Lasers Med Sci. 2015 Sep;30(7):2009-14 (medline /25359622)
CM - Cites: Dermatol Surg. 2004 Sep;30(9):1214-8 (medline /15355363)
CM - Cites: Hautarzt. 2016 Jun;67(6):483-99 (medline /27206448)
CM - Cites: J Eur Acad Dermatol Venereol. 2016 Apr;30 Suppl 3:12-6 (medline
/26995017)
CM - Cites: Ann Plast Surg. 2014 Nov;73(5):552-8 (medline /23407256)
CM - Cites: Lasers Surg Med. 2016 Feb;48(2):133-9 (medline /26392001)
CM - Cites: Br J Dermatol. 2008 Jul;159(1):35-48 (medline /18593385)
CM - Cites: J Am Acad Dermatol. 2011 Apr;64(4):723-9 (medline /21414496)
CM - Cites: Lasers Surg Med. 2011 Feb;43(2):72-8 (medline /21384387)
CM - Cites: J Biomed Opt. 2014 Mar;19(3):30901 (medline /24604472)
CM - Cites: Lasers Surg Med. 2014 Jan;46(1):1-7 (medline /24272664)
CM - Cites: J Eur Acad Dermatol Venereol. 2009 Mar;23 (3):308-13 (medline
/19207641)
CM - Cites: Arch Dermatol Res. 2015 Aug;307(6):515-22 (medline /25832754)
CM - Cites: Br J Dermatol. 2015 Mar;172(3):677-83 (medline /25040296)
CM - Cites: Lasers Surg Med. 2015 Feb;47(2):106-10 (medline /25645536)
CM - Cites: Clin Dermatol. 2017 Nov - Dec;35(6):517-529 (medline /29191344)
CM - Cites: Eur J Dermatol. 2010 Nov-Dec;20(6):738-42 (medline /21056940)
CM - Cites: Acta Dermatovenerol Alp Pannonica Adriat. 2013 Sep;22(3):57-61
(medline /24089133)
CM - Cites: Lasers Surg Med. 2008 Feb;40(2):153-8 (medline /18306163)
CM - Cites: Br J Dermatol. 2015 Jan;172(1):215-22 (medline /24903544)
CM - Cites: Biomed Res Int. 2016;2016:7981640 (medline /27631010)
CM - Cites: J Skin Cancer. 2012;2012:286480 (medline /23316366)
CM - Cites: Dermatol Surg. 2003 Jan;29(1):80-4 (medline /12534517)
CM - Cites: J Am Acad Dermatol. 2016 May;74(5):981-1004 (medline /26936299)
CM - Cites: Oncol Lett. 2013 Oct;6(4):939-941 (medline /24137440)
CM - Cites: Arch Dermatol. 1998 Oct;134(10):1247-52 (medline /9801680)
CM - Cites: J Biomed Opt. 2017 Aug;22(8):1-13 (medline /28831793)
CM - Cites: Acta Derm Venereol. 2016 Mar;96(3):355-60 (medline /26537095)
CM - Cites: Lasers Med Sci. 2011 Sep;26(5):641-4 (medline /21748324)
CM - Cites: J Eur Acad Dermatol Venereol. 2016 Apr;30 Suppl 3:46-51 (medline
/26995023)
DOCNO- medline/29236125

516 - TOXLINE
TI - First-Principle Molecular Dynamics Investigation of Waterborne As-V
Species.
AU - Borah S
AD - Department of Physics , Indian Institute of Technology Guwahati , Guwahati ,
Assam 781039 , India.
AU - Kumar PP
AD - Department of Physics , Indian Institute of Technology Guwahati , Guwahati ,
Assam 781039 , India.
SO - J Phys Chem B. 2018, 03 29; 122(12):3153-3162. [The journal of physical
chemistry. B]
AB - The toxicity, mobility, and geochemical behaviors of arsenic are known to
vary enormously with its speciation and oxidation states. The present work
details results on the basis of ab initio molecular dynamics analysis of
various waterborne As-V species, namely, H3AsO4, H2AsO4-, HAsO42-, and
AsO43-. The nature of hydrogen bonding of these species with water and its
influence on the solvent structure and relaxation behavior are discussed.
Useful microscopic insights on the structural and spectroscopic signatures
of the species in aqueous media are reported. Comparison of normal-mode
frequencies of the species in gas phases to the vibrational density of
states in solution provides insights on the influences of solvation and H
bonding. The results are compared with the previous experimental and
simulation studies, where available.
LA - eng
IS - 1520-5207 (Electronic)
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
TA - J Phys Chem B
YR - 2018
DATE- 20180503
CITO- NLM
CS - United States
FJT - The journal of physical chemistry. B
EDAT- 20180315
STAT- PubMed-not-MEDLINE
DOCNO- medline/29494154

517 - TOXLINE
TI - Environmental Influences on the Epigenome: Exposure-Associated DNA
Methylation in Human Populations.
AU - Martin EM
AD - Department of Environmental Sciences and Engineering, and Curriculum in
Toxicology, Grillings School of Global Public Heatlh, University of North Carolina,
Chapel Hill, North Carolina 27599, USA; email: emsebas@live.unc.edu , rfry@unc.edu.
AU - Fry RC
AD - Department of Environmental Sciences and Engineering, and Curriculum in
Toxicology, Grillings School of Global Public Heatlh, University of North Carolina,
Chapel Hill, North Carolina 27599, USA; email: emsebas@live.unc.edu , rfry@unc.edu.
SO - Annu Rev Public Health. 2018, Jan 12. [Annual review of public health]
AB - DNA methylation is the most well studied of the epigenetic regulators in
relation to environmental exposures. To date, numerous studies have
detailed the manner by which DNA methylation is influenced by the
environment, resulting in altered global and gene-specific DNA
methylation. These studies have focused on prenatal, early-life, and adult
exposure scenarios. The present review summarizes currently available
literature that demonstrates a relationship between DNA methylation and
environmental exposures. It includes studies on aflatoxin B1, air
pollution, arsenic, bisphenol A, cadmium, chromium, lead, mercury,
polycyclic aromatic hydrocarbons, persistent organic pollutants, tobacco
smoke, and nutritional factors. It also addresses gaps in the literature
and future directions for research. These gaps include studies of
mixtures, sexual dimorphisms with respect to environmentally associated
methylation changes, tissue specificity, and temporal stability of the
methylation marks. Expected final online publication date for the Annual
Review of Public Health Volume 39 is April 1, 2018. Please see
http://www.annualreviews.org/page/journal/pubdates for revised estimates.
LA - eng
IS - 1545-2093 (Electronic)
PT - Journal Article
TA - Annu Rev Public Health
YR - 2018
DATE- 20180112
CITO- NLM
CS - United States
FJT - Annual review of public health
EDAT- 20180112
STAT- Publisher
DOCNO- medline/29328878

518 - TOXLINE
TI - Neuromast hair cells retain the capacity of regeneration during heavy
metal exposure.
AU - Montalbano G
AD - Department of Veterinary Sciences, University of Messina, Zebrafish
Neuromorphology Lab, Italy.
AU - Capillo G
AD - Department of Chemical, Biological, Pharmaceutical and Environmental
Sciences, University of Messina, Italy.
AU - Laur� R
AD - Department of Veterinary Sciences, University of Messina, Zebrafish
Neuromorphology Lab, Italy.
AU - Abbate F
AD - Department of Veterinary Sciences, University of Messina, Zebrafish
Neuromorphology Lab, Italy.
AU - Levanti M
AD - Department of Veterinary Sciences, University of Messina, Zebrafish
Neuromorphology Lab, Italy.
AU - Guerrera MC
AD - Department of Veterinary Sciences, University of Messina, Zebrafish
Neuromorphology Lab, Italy. Electronic address: mguerrera@unime.it.
AU - Ciriaco E
AD - Department of Veterinary Sciences, University of Messina, Zebrafish
Neuromorphology Lab, Italy.
AU - German� A
AD - Department of Veterinary Sciences, University of Messina, Zebrafish
Neuromorphology Lab, Italy.
SO - Ann Anat. 2018, Jul; 218:183-189. [Annals of anatomy = Anatomischer
Anzeiger : official organ of the Anatomische Gesellschaft]
AB - The neuromast is the morphological unit of the lateral line of fishes and
is composed of a cluster of central sensory cells (hair cells) surrounded
by support and mantle cells. Heavy metals exposure leads to disruption of
hair cells within the neuromast. It is well known that the zebrafish has
the ability to regenerate the hair cells after damage caused by toxicants.
The process of regeneration depends on proliferation, differentiation and
cellular migration of sensory and non-sensory progenitor cells. Therefore,
our study was made in order to identify which cellular types are involved
in the complex process of regeneration during heavy metals exposure. For
this purpose, adult zebrafish were exposed to various heavy metals
(Arsenic, cadmium and zinc) for 72h. After acute (24h) exposure,
immunohistochemical localization of S100 (a specific marker for hair
cells) in the neuromasts highlighted the hair cells loss. The
immunoreaction for Sox2 (a specific marker for stem cells), at the same
time, was observed in the support and mantle cells, after exposure to
arsenic and cadmium, while only in the support cells after exposure to
zinc. After chronic (72h) exposure the hair cells were regenerated,
showing an immunoreaction for S100 protein. At the same exposure time to
the three metals, a Sox2 immunoreaction was expressed in support and
mantle cells. Our results showed for the first time the regenerative
capacity of hair cells, not only after, but also during exposure to heavy
metals, demonstrated by the presence of different stem cells that can
diversify in hair cells.
KW - Hair cells
KW - Heavy metals
KW - Lateral line
KW - Neuromast
KW - Regeneration
KW - Zebrafish
LA - eng
IS - 1618-0402 (Electronic)
PT - Journal Article
TA - Ann Anat
YR - 2018
DATE- 20180612
CI - Copyright &copy; 2018 Elsevier GmbH. All rights reserved.
CITO- NLM
CS - Germany
FJT - Annals of anatomy = Anatomischer Anzeiger : official organ of the
Anatomische Gesellschaft
EDAT- 20180430
STAT- In-Process
DOCNO- medline/29719206

519 - TOXLINE
TI - Linkage between human population and trace elements in soils of the Pearl
River Delta: Implications for source identification and risk assessment.
AU - Lin Y
AD - Department of Environmental Health Sciences, Jonathan and Karin Fielding
School of Public Health, University of California, Los Angeles, CA 90095, United
States.
AU - Ma J
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Beijing 100012, China. Electronic
address: majin@craes.org.cn.
AU - Zhang Z
AD - School of Geography, South China Normal University, Guangzhou 510631, China.
AU - Zhu Y
AD - Department of Environmental Health Sciences, Jonathan and Karin Fielding
School of Public Health, University of California, Los Angeles, CA 90095, United
States.
AU - Hou H
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Beijing 100012, China.
AU - Zhao L
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Beijing 100012, China.
AU - Sun Z
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Beijing 100012, China.
AU - Xue W
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Beijing 100012, China.
AU - Shi H
AD - State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese
Research Academy of Environmental Sciences, Beijing 100012, China. Electronic
address: shihd@craes.org.cn.
SO - Sci Total Environ. 2018, Jan 01; 610-611:944-950. [The Science of the
total environment]
AB - The human population is both an emitter and receptor of metals. This study
aims to clarify how the relationship of metals and metalloids to human
populations influences their source characterization and health risk,
based on metal concentrations in 298 soil samples in the Pearl River Delta
(PRD) and the corresponding zip-code level population. Nickel (Ni), copper
(Cu), zinc (Zn), cadmium (Cd), mercury (Hg), and lead (Pb), but not
chromium (Cr) and arsenic (As), were significantly correlated with
population (p < 0.01), suggesting potential anthropogenic sources. A
principal component analysis (PCA) revealed three factors (i.e., F1, F2,
and F3) contributing to metal levels in the PRD: (1) metal transport from
rivers (F1), which explained the high levels of Cr, Ni, Cu, Zn, As, and Cd
in downstream areas; (2) industrial sources (F2), mainly contributing to
Ni, Cu, Zn, Cd, Hg, and Pb; and (3) natural and agricultural sources (F3),
mainly contributing to As and Pb. F2 was significantly correlated with
population, while F3 was not, indicating that an analysis of the
correlation with population could be used to identify industrial sources
of metals. Compared with directly calculated risks, the
population-weighted non-carcinogenic and carcinogenic risks were increased
by 4.2-4.9% and 7.7-9.2%, respectively. A unit increase in the
concentration of industrial metals led to higher extra risks than a
corresponding increase in natural metals due to the proximity to human
populations.
KW - Human population
KW - Metal and metalloid
KW - Risk assessment
KW - Soil
KW - Source identification
LA - eng
IS - 1879-1026 (Electronic)
PT - Journal Article
TA - Sci Total Environ
YR - 2018
DATE- 20180103
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - The Science of the total environment
EDAT- 20170819
STAT- In-Process
DOCNO- medline/28830054

520 - TOXLINE
TI - Arsenic-Induced Neuropathy by Improper Use of Chinese Medicine: A Case
Report.
AU - Chang RS
AD - Division of Neurology, Department of Medicine, Queen Mary Hospital, Hong
Kong, China.
AU - William Leung CY
AD - Department of Medicine, Queen Mary Hospital, Hong Kong, China.
AU - Cheung TT
AD - Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong
Kong, Hong Kong, China.
AU - Chan CK
AD - Hong Kong Poison Information Centre, United Christian Hospital, Hong Kong
SAR, China.
SO - Am J Ther. 2018 May/Jun; 25(3):e392-e393. [American journal of
therapeutics]
LA - eng
IS - 1536-3686 (Electronic)
PT - Journal Article
TA - Am J Ther
YR - 2018
DATE- 20180503
CITO- NLM
CS - United States
FJT - American journal of therapeutics
STAT- In-Data-Review
DOCNO- medline/28394768

521 - TOXLINE
TI - Novel bacterial selenite reductase CsrF responsible for Se(IV) and Cr(VI)
reduction that produces nanoparticles in Alishewanella sp. WH16-1.
AU - Xia X
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
AU - Wu S
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
AU - Li N
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
AU - Wang D
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
AU - Zheng S
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
AU - Wang G
AD - State Key Laboratory of Agricultural Microbiology, College of Life Science
and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China.
Electronic address: gejiao@mail.hzau.edu.cn.
SO - J Hazard Mater. 2018, Jan 15; 342:499-509. [Journal of hazardous
materials]
AB - Alishewanella sp. WH16-1 is a facultative anaerobic bacterium isolated
from mining soil. Under aerobic conditions, this bacterium efficiently
reduces selenite and chromate. A flavoprotein showing 37% amino acid
identity to E. coli chromate reductase ChrR was identified from the genome
(named CsrF). Gene mutation and complementation along with heterologous
expression revealed the ability of CsrF to reduce selenite and chromate in
vivo. The purified CsrF was yellow and showed an absorption spectra
similar to that of FMN. The molecular weight of CsrF was 23,906 for the
monomer and 47,960 for the dimer. In vitro, CsrF catalyzes the reduction
of Se(IV) and Cr(VI) using NAD(P)H as cofactors with optimal condition of
pH 7.0 and temperature of 30-37&deg;C. This enzyme also catalyze the
reduction of sulfate and ferric iron but not arsenate and nitrate. Using
NADPH as its electron donor, the Km for the reduction of Se(IV) and Cr(VI)
was 204.1&plusmn;27.91 and 250.6&plusmn;23.46&mu;mol/L, respectively.
Site-directed mutagenesis showed that Arg13 and Gly113 were essential for
the reduction of Se(IV) and Cr(VI). The products of the reduction of
Se(IV) and Cr(VI) were Se(0)- and Cr(III)-nanoparticles, respectively. To
our knowledge, CsrF is a novel and well-characterized bacterial aerobic
selenite reductase.
KW - Alishewanella
KW - Chromate reductase
KW - Cr(III)-nanoparticles
KW - Se(0)-nanoparticles
KW - Selenite reductase
LA - eng
IS - 1873-3336 (Electronic)
PT - Journal Article
TA - J Hazard Mater
YR - 2018
DATE- 20180103
CI - Copyright &copy; 2017 Elsevier B.V. All rights reserved.
CITO- NLM
CS - Netherlands
FJT - Journal of hazardous materials
EDAT- 20170824
STAT- In-Process
DOCNO- medline/28881274

522 - TOXLINE
TI - Correction to: Biochars mitigate greenhouse gas emissions and
bioaccumulation of potentially toxic elements and arsenic speciation in
Phaseolus vulgaris L.
AU - Ibrahim M
AD - University of Chinese Academy of Sciences, Beijing, 100049, People's Republic
of China.
AU - Li G
AD - Zhejiang Provincial Key Laboratory of Subtropic Soil and Plant Nutrition,
Zhejiang University, Hangzhou, 310058, People's Republic of China. gli@iue.ac.cn.
AU - Khan S
AD - Department of Environmental Sciences, University of Peshawar, Peshawar,
25120, Pakistan.
AU - Chi Q
AD - Key Laboratory of Urban Environment and Health, Institute of Urban
Environment, Chinese Academy of Sciences, Xiamen, 361021, People's Republic of
China.
AU - Xu Y
AD - Key Lab of Urban Environmental Processes and Pollution Control, Ningbo Urban
Environment Observatory and Monitoring Station, Chinese Academy of Sciences,
Ningbo, 315830, People's Republic of China.
AU - Zhu Y
AD - State Key Lab of Urban and Regional Ecology, Research Center for Eco-
Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, People's
Republic of China.
SO - Environ Sci Pollut Res Int. 2018, 05; 25(15):15264. [Environmental science
and pollution research international]
AB - The original version of this article unfortunately contained a mistake.
One affiliation and one author were missing. The corrected affiliations
and authors are given here.
LA - eng
IS - 1614-7499 (Electronic)
PT - Journal Article
PT - Published Erratum
TA - Environ Sci Pollut Res Int
YR - 2018
DATE- 20180611
CITO- NLM
CS - Germany
FJT - Environmental science and pollution research international
STAT- PubMed-not-MEDLINE
CM - Erratum for: Environ Sci Pollut Res Int. 2017 Aug;24(24):19524-19534
(medline /28681292)
DOCNO- medline/29063988

523 - TOXLINE
TI - Clinical Aspects of Opium Adulterated with Lead in Iran: A Review.
AU - Alinejad S
AD - Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University
of Medical Sciences, Birjand, Iran.
AU - Aaseth J
AD - Norway University of Applied Sciences, Elverum and Research Department,
Innlandet Hospital, Brumunddal, Norway.
AU - Abdollahi M
AD - Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran
University of Medical Sciences, Tehran, Iran.
AU - Hassanian-Moghaddam H
AD - Toxicological Research Center, Department of Clinical Toxicology, Shahid
Beheshti University of Medical Sciences, Tehran, Iran.
AU - Mehrpour O
AD - Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University
of Medical Sciences, Birjand, Iran.
SO - Basic Clin Pharmacol Toxicol. 2018, Jan; 122(1):56-64. [Basic & clinical
pharmacology & toxicology]
AB - Adulteration of drugs with poisonous substances during production or
consumption has caused numerous health problems. Among contaminants that
have the potential of producing poisonous effects are the heavy metals
lead, arsenic and thallium that make up an important group of toxic
substances. The emergence of these new health problems related to opioid
abuse has precipitated this MiniReview on the status of the most hazardous
and common opioid adulterants. In fact, adulterated opium is a major
public health problem and can threaten the health of users. In this study,
we searched for information on opium, opiates, lead poisoning, toxicity,
intoxication, Iran and heavy metals in the TUMS Digital Library, PubMed,
Scopus, EMBASE and Google Scholar bibliographical databases. This
MiniReview primarily included articles on lead poisoning, signs and
symptoms, and management in opioid-dependent individuals. Exclusion
criteria were articles dealing with animal studies, specific paediatric
studies, adulterants other than heavy metals and substances other than
opioids. Adulterated opium is one of the new sources of exposure to lead
and has precipitated an increase in lead-poisoned cases owing to the
widespread use of opium. The toxicology of lead and general guidelines on
diagnosis and treatment of lead poisoning is briefly reviewed. The
symptoms of lead toxicity mimic several diseases often leading to
unnecessary diagnostic methods, misdiagnoses and even surgery. Finally,
owing to the fact that lead toxicity shows non-specific signs and
symptoms, screening for this disease, by taking blood samples and
assessing blood lead levels in high-risk people, should be given an utmost
priority. It is recommended that screening tests are adopted and applied
for any drug-abusing patient with non-specific subacute signs and symptoms
like abdominal pain, constipation and anaemia.
LA - eng
IS - 1742-7843 (Electronic)
PT - Journal Article
PT - Review
TA - Basic Clin Pharmacol Toxicol
YR - 2018
DATE- 20171222
CI - &copy; 2017 Nordic Association for the Publication of BCPT (former Nordic
Pharmacological Society).
CITO- NLM
CS - England
FJT - Basic &amp; clinical pharmacology &amp; toxicology
EDAT- 20171018
STAT- In-Process
DOCNO- medline/28802093

524 - TOXLINE
TI - DUOX expression in human keratinocytes and bronchial epithelial cells:
Influence of vanadate.
AU - Hill T 3rd
AD - Department of Environmental Toxicology, University of California at Davis,
USA.
AU - Rice RH
AD - Department of Environmental Toxicology, University of California at Davis,
USA. Electronic address: rhrice@ucdavis.edu.
SO - Toxicol In Vitro. 2018, Feb; 46:257-264. [Toxicology in vitro : an
international journal published in association with BIBRA]
AB - Dual oxygenases (DUOX) 1 and 2, expressed in many animal tissues,
participate in host defense at mucosal surfaces and may have important
signaling roles through generation of reactive oxygen. Present work
addresses their expression in cultured human epidermal keratinocytes and
effects of cytokines and metal/metalloid compounds. Both DUOX1 and 2 were
expressed at much higher levels after confluence than in the preconfluent
state. Maximal DUOX1 mRNA levels were 50 fold those of DUOX2. DUOX1 and 2
were induced &asymp;3 fold by interleukin 4, but only DUOX1 was induced by
interferon gamma (IFN&gamma;). In human bronchial HBE1 cells, by contrast,
interleukin 4 induced only DUOX 1, and IFN&gamma; induced only DUOX2. A
survey in the keratinocytes of metal/metalloid compounds showed that
arsenite, antimonite, chromate, cadmium, copper, lead and vanadate
suppressed DUOX1 levels but did not prevent interleukin 4 stimulation.
Effects on DUOX2 were less dramatic, except that vanadate potentiated the
stimulation by IFN&gamma; up to 7 fold. The results indicate that
epithelial cell types of different tissue origins can differ in their
cytokine regulation and that epidermal cells can exhibit striking
alterations in response due to certain metal/metalloid exposures.
KW - DUOX
KW - Human bronchial cells
KW - Human epidermal keratinocytes
KW - Interferon γ
KW - Interleukin 4
KW - Vanadate
LA - eng
IS - 1879-3177 (Electronic)
PT - Journal Article
TA - Toxicol In Vitro
YR - 2018
DATE- 20171219
CI - Copyright &copy; 2017 Elsevier Ltd. All rights reserved.
CITO- NLM
CS - England
FJT - Toxicology in vitro : an international journal published in association
with BIBRA
EDAT- 20171012
STAT- In-Process
CM - Cites: Environ Chem. 2016;13(6):963-970 (medline /28713220)
CM - Cites: J Clin Invest. 2008 Dec;118(12):3980-9 (medline /19033667)
CM - Cites: J Dermatol Sci. 2014 Apr;74(1):56-63 (medline /24332816)
CM - Cites: JAKSTAT. 2014 Jan 1;3(1):e28087 (medline /24778927)
CM - Cites: J Biol Chem. 2006 Jul 7;281(27):18269-72 (medline /16651268)
CM - Cites: Environ Pollut. 2015 Jan;196:450-61 (medline /25468213)
CM - Cites: J Colloid Interface Sci. 2011 Jun 15;358(2):534-40 (medline
/21457993)
CM - Cites: Contact Dermatitis. 2013 Apr;68(4):232-8 (medline /23343440)
CM - Cites: Environ Sci Technol. 2007 May 15;41(10):3769-74 (medline /17547211)
CM - Cites: J Biol Chem. 2005 Aug 26;280(34):30046-54 (medline /15972824)
CM - Cites: Am J Respir Crit Care Med. 2007 Jan 15;175(2):174-83 (medline
/17082494)
CM - Cites: N Engl J Med. 2002 Jul 11;347(2):95-102 (medline /12110737)
CM - Cites: J Biol Chem. 2016 Oct 28;291(44):23282-23293 (medline /27650496)
CM - Cites: J Immunol. 2011 Apr 15;186(8):4762-70 (medline /21411736)
CM - Cites: Methods Enzymol. 1991;201:477-82 (medline /1943774)
CM - Cites: Biochimie. 2007 Sep;89(9):1107-12 (medline /17400358)
CM - Cites: Am J Physiol. 1993 May;264(5 Pt 1):C1219-30 (medline /7684560)
CM - Cites: J Biol Chem. 1999 Dec 24;274(52):37265-9 (medline /10601291)
CM - Cites: FASEB J. 2003 Aug;17(11):1502-4 (medline /12824283)
CM - Cites: Eur J Clin Invest. 1988 Oct;18(5):433-43 (medline /2852593)
CM - Cites: J Cell Physiol. 2003 Apr;195(1):99-107 (medline /12599213)
CM - Cites: Science. 2002 Jun 21;296(5576):2143-5 (medline /12077387)
CM - Cites: Annu Rev Pathol. 2014;9:119-45 (medline /24050626)
CM - Cites: Environ Sci Technol. 2007 Aug 1;41(15):5245-51 (medline /17822086)
CM - Cites: Environ Health Perspect. 2007 May;115(5):734-42 (medline /17520061)
CM - Cites: Biochem Biophys Res Commun. 2010 Apr 30;395(2):270-4 (medline
/20381453)
CM - Cites: Sci Total Environ. 2017 Feb 1;579:1643-1648 (medline /28040195)
CM - Cites: Mol Cell Biol. 1993 Dec;13(12):7515-21 (medline /8246969)
CM - Cites: J Invest Dermatol. 2008 Jan;128(1):214-22 (medline /17611574)
CM - Cites: FEBS J. 2008 Jul;275(13):3249-77 (medline /18513324)
CM - Cites: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10188-93 (medline
/10468584)
CM - Cites: FEBS Lett. 2005 Aug 29;579(21):4911-7 (medline /16111680)
CM - Cites: Sci Signal. 2013 Feb 05;6(261):ra8 (medline /23386745)
CM - Cites: Annu Rev Immunol. 1989;7:277-307 (medline /2523713)
CM - Cites: Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1549-61 (medline
/16987010)
CM - Cites: Science. 2007 Mar 23;315(5819):1659-61 (medline /17379786)
CM - Cites: Environ Health. 2016 Sep 01;15(1):94 (medline /27586245)
CM - Cites: Prev Vet Med. 2006 Oct 17;76(3-4):167-84 (medline /16797093)
CM - Cites: J Invest Dermatol. 2009 Jan;129(1):155-61 (medline /18633435)
CM - Cites: Biochem Soc Symp. 2004;(71):85-96 (medline /15777014)
CM - Cites: J Dairy Sci. 2013 Apr;96(4):2637-2648 (medline /23403202)
CM - Cites: J Invest Dermatol. 2007 Feb;127(2):354-61 (medline /16977326)
CM - Cites: Toxicol Appl Pharmacol. 2011 Aug 1;254(3):323-31 (medline
/21605584)
CM - Cites: Rev Environ Contam Toxicol. 2017;242:1-60 (medline /27464847)
CM - Cites: Int J Cancer. 2001 Dec 1;94(5):669-73 (medline /11745461)
CM - Cites: J Invest Dermatol. 2011 Jun;131(6):1216-25 (medline /21307872)
CM - Cites: Mol Biol Cell. 1993 Feb;4(2):185-94 (medline /8443416)
DOCNO- medline/29031483

525 - TOXLINE
TI - Bioaccumulation and sources of metal(loid)s in lilies and their potential
health risks.
AU - Sun H
AD - School of Environment, Beijing Normal University, Beijing 100875, China.
AU - Cheng H
AD - School of Environment, Beijing Normal University, Beijing 100875, China.
Electronic address: chg@bnu.edu.cn.
AU - Lin L
AD -School of Environment, Beijing Normal University, Beijing 100875, China.
AU -Deng K
AD -School of Environment, Beijing Normal University, Beijing 100875, China.
AU -Cui X
AD -School of Environment, Beijing Normal University, Beijing 100875, China.
SO -Ecotoxicol Environ Saf. 2018, Apr 30; 151:228-235. [Ecotoxicology and
environmental safety]
AB - Dietary intake of metal(loid)s can seriously affect human health, but the
levels, the bioaccumulation, sources and related health risks of As, Cd,
Cr and Pb in cultivated lilies, particularly for Lilium davidii var.
unicolor, remain unresolved. We collected 35 lily samples aged 1-6 years
from farmlands of two types of soil (heilu soils and loessal soils) in
Qilihe district in 2016 and analysed the concentrations of As, Cd, Cr and
Pb in bulbs, the soil-bulb bioaccumulation and the potential sources of
these elements in bulbs. Non-carcinogenic and carcinogenic risks by
consuming lilies were also assessed. Concentrations of four elements
decreased in the order of Cr > Pb > Cd > As, and soil-bulb BCFs
in the order of BCFCd > BCFCr > BCFPb > BCFAs. The Cd
concentration of bulbs of lilies which grew in heilu soils was
statistically higher than that of bulbs of lilies which grew in loessal
soils, and the Cd concentration of bulbs of lilies aged 1-3 years was
statistically higher than that of bulbs of lilies aged 4-6 years. Levels
and soil-bulb BCFs of Cr and Pb of two-bulbed lilies were statistically
higher than those of one-bulbed lilies. Farmyard manure may be a primary
source of Cd in soil. There existed overall potential non-carcinogenic
effects by exposure to the combination of four elements. Dietary intake of
Cr posed carcinogenic risks to both adults and children. Non-carcinogenic
and carcinogenic risks were higher for adults than children. Concluding,
the edible parts of lily were significantly polluted by Cr and Pb but not
by As and Cd. The number of bulbs significantly impacted concentrations
and soil-bulb BCFs of Cr and Pb, but the reason for which needs further
studies. Non-carcinogenic and carcinogenic risks caused by lily
consumption should not be neglected.
KW - Bioconcentration factor
KW - Dietary intake
KW - Lilium davidii var. unicolor
KW - Number of bulbs
KW - Soil type
KW - Trace elements
RN - 00BH33GNGH
RN - 0R0008Q3JB
RN - 2P299V784P
RN - N712M78A8G
LA - eng
IS - 1090-2414 (Electronic)
PT - Journal Article
TA - Ecotoxicol Environ Saf
YR - 2018
DATE- 20180530
CI - Copyright &copy; 2017. Published by Elsevier Inc.
CITO- NLM
CS - Netherlands
CSET- IM
FJT - Ecotoxicology and environmental safety
EDAT- 20180130
STAT- MEDLINE
DOCNO- medline/29353172

526 - TOXLINE
TI - Metal and Isotope Analysis of Bird Feathers in a Contaminated Estuary
Reveals Bioaccumulation, Biomagnification, and Potential Toxic Effects.
AU - Einoder LD
AD - c/o Prof. Stephen Garnett, Charles Darwin University, Darwin, NT, 0909,
Australia. lukeeinoder@gmail.com.
AU - MacLeod CK
AD - Tasmanian Aquaculture and Fisheries Institute, University of Tasmania,
Nubeena Cresent, Taroona, Hobart, TAS, 7053, Australia.
AU - Coughanowr C
AD - Derwent Estuary Program Ltd, 24 Davey Street, Hobart, TAS, 7001, Australia.
SO - Arch Environ Contam Toxicol. 2018, Jul; 75(1):96-110. [Archives of
environmental contamination and toxicology]
AB - The Derwent estuary, in south east Tasmania, is highly contaminated with
heavy metals, mainly due to past industrial pollution. This study sought
to determine the extent of contamination, bioaccumulation, and
biomagnification in the resident bird community and therefore to infer the
potential for adverse effects in birds. Thirteen metals were measured from
breast feathers (n&thinsp;=&thinsp;51 individuals) of eight sympatric
species of aquatic bird. Stable carbon (&delta;13C) and nitrogen
(&delta;15N) isotopes were used to identify dietary sources of
contaminants, trophic level, and potential biomagnification through food
chains. Generalised linear models revealed that metal burdens were often
poorly correlated with &delta; 13C, indicating their uptake from a range
of freshwater, brackish, and marine carbon sources-not surprising due to
widespread contamination across the tidal estuary. Feather mercury
increased significantly with trophic level (inferred from &delta;15N).
White-bellied Sea-eagle Haliaeetus leucogaster samples contained 240 times
more mercury than feral Goose Anser cygnoides. Feather arsenic and copper
concentrations were significantly higher in birds feeding lower in the
food chain. For several piscivorous species, both chick and adults were
sampled revealing significantly higher feather mercury, zinc, and selenium
in adults. Feathers from birds found dead along the banks of the estuary
had significantly higher lead loads than from live birds, and numerous
individuals had levels of mercury, zinc, and lead above toxic thresholds
reported in other studies. These results highlight the need to include
biota from higher trophic levels in contaminant monitoring programs to
understand fully the fate and broader implications of contaminants in the
environment.
RN - FXS1BY2PGL
RN - H6241UJ22B
RN - N712M78A8G
LA - eng
IS - 1432-0703 (Electronic)
PT - Journal Article
TA - Arch Environ Contam Toxicol
YR - 2018
DATE- 20180618
CITO- NLM
CS - United States
CSET- IM
FJT - Archives of environmental contamination and toxicology
EDAT- 20180505
STAT- MEDLINE
DOCNO- medline/29730716

You might also like