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Group 2C
This journal is a research article to characterize alloantibodies produced by patients with sickle cell
disease.
Authors: Woldie, I., Swerdlow, P., Bluth, M.H., Mohammad, U., Landolfi, E., Chaudrhy, S.,
Dyson, G., & O'Malley, B. A.
Title: Lifetime risk and characterization of red blood cell alloimmunization in chronically
transfused patients with sickle cell disease
International Journal of Blood Transfusion and Immunohatology, Volume 5; 2015; 1-5
Issues discussed: Lifetime risks of alloantibody generation in patients with sickle cell disease
Purpose: To estimate and characterize alloantibodies developing over a lifetime in patients with
sickle cell disease who are on chronic red cell transfusion.
Method: Descriptive statistical method
Conclusion: The study showed high rate of alloimmunization for patients with sickle cell disease on
chronic red cell exchange transfusion.
Is the abstract specific, representative of the article and in the correct form?
Yes. In the abstract, every part of the article is summarized properly and important points are
mentioned which makes it complete and interesting.
Is the objective of the experiment or of the observations important for the field?
Yes because many deaths are already recorded because of sickle cell disease so knowing the risks of
curing it can help prevent further complications and presenting the root cause of the complications
can help the people understand more.
Reference:
Woldie, I., Swerdlow, P., Bluth, M., Mohammad, U., Landolfi, E., Chaudrhy, S., . . . O'Malley, B.
(2015). Lifetime risk and characterization of red blood cell alloimmunization in chronically
transfused patients with sickle cell disease. International Journal of Blood Transfusion and
Immunohatology, 5, 1-5. doi:10.5348/ijbti-2015-15-OA-1