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LEONES, CASMIN CLAIRE T.

Group 2C

This journal is a research article to characterize alloantibodies produced by patients with sickle cell
disease.

Authors: Woldie, I., Swerdlow, P., Bluth, M.H., Mohammad, U., Landolfi, E., Chaudrhy, S.,
Dyson, G., & O'Malley, B. A.
Title: Lifetime risk and characterization of red blood cell alloimmunization in chronically
transfused patients with sickle cell disease
International Journal of Blood Transfusion and Immunohatology, Volume 5; 2015; 1-5
Issues discussed: Lifetime risks of alloantibody generation in patients with sickle cell disease
Purpose: To estimate and characterize alloantibodies developing over a lifetime in patients with
sickle cell disease who are on chronic red cell transfusion.
Method: Descriptive statistical method
Conclusion: The study showed high rate of alloimmunization for patients with sickle cell disease on
chronic red cell exchange transfusion.

Is the title of the article appropriate and clear?


Yes, the authors made the title of the article as simple as possible in order for the readers to clearly
understand the topic to be discussed.

Is the abstract specific, representative of the article and in the correct form?
Yes. In the abstract, every part of the article is summarized properly and important points are
mentioned which makes it complete and interesting.

Is the purpose of the article made clear in the introduction?


Yes, the author also stated results from other researches and factors that may contribute to the
problem of the study. This can help the readers understand more the purpose of performing this
study.

Do you find errors of fact and interpretation?


No because the authors stated in the study the facts proven by the authors in its references. The
authors of this article also stated the contrasting results of some researches to prove that there is no
bias in the results.

Is all of the discussion relevant?


Yes. All possibilities and factors that can affect the result are discussed and elaborated. Many other
studies are cited to support the study and table of results are presented.

Has the author cited the pertinent literature?


Yes . As you can see in the references, all the articles used are related to the study in order to prove
the theories and results of the authors to make the article. Some are not directly related but are
useful for further investigations and more researches.

Is the objective of the experiment or of the observations important for the field?
Yes because many deaths are already recorded because of sickle cell disease so knowing the risks of
curing it can help prevent further complications and presenting the root cause of the complications
can help the people understand more.

Reference:
Woldie, I., Swerdlow, P., Bluth, M., Mohammad, U., Landolfi, E., Chaudrhy, S., . . . O'Malley, B.
(2015). Lifetime risk and characterization of red blood cell alloimmunization in chronically
transfused patients with sickle cell disease. International Journal of Blood Transfusion and
Immunohatology, 5, 1-5. doi:10.5348/ijbti-2015-15-OA-1

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