LEONES, CASMIN CLAIRE T.

Group 2C

This journal is a research article to characterize alloantibodies produced by patients with sickle cell
disease.

Authors: Woldie, I., Swerdlow, P., Bluth, M.H., Mohammad, U., Landolfi, E., Chaudrhy, S.,
Dyson, G., & O'Malley, B. A.
Title: Lifetime risk and characterization of red blood cell alloimmunization in chronically
transfused patients with sickle cell disease
International Journal of Blood Transfusion and Immunohatology, Volume 5; 2015; 1-5
Issues discussed: Lifetime risks of alloantibody generation in patients with sickle cell disease
Purpose: To estimate and characterize alloantibodies developing over a lifetime in patients with
sickle cell disease who are on chronic red cell transfusion.
Method: Descriptive statistical method
Conclusion: The study showed high rate of alloimmunization for patients with sickle cell disease on
chronic red cell exchange transfusion.

The title is appropriate and clear. The authors made the title of the article as simple as possible in
order for the readers to clearly understand the topic to be discussed.

The abstract is very specific, representative of the article and in the correct order according to the
body of the article. In the abstract, every part of the article is summarized properly and important
points are mentioned which makes it complete and interesting.

The purpose of the article is stated clearly in the introduction and made it understandable for all
readers. The author also stated results from other researches and factors that may contribute to the
problem of the study. This can help the readers understand more the purpose of performing this
study.

I can't see any errors of fact and interpretation in the article because the authors stated in the study
the facts proven by the authors in its references. The authors of this article also stated the
contrasting results of some researches to prove that there is no bias in the results.

The discussion made is relevant. All possibilities and factors that can affect the result are discussed
and elaborated. Many other studies are cited to support the study and table of results are presented.

All the cited literature are connected and pertinent to the article. As you can see in the references,
all the articles used are related to the study in order to prove the theories and results of the authors
to make the article. Some are not directly related but are useful for further investigations and more
researches.

The objective of the experiment is important for the field because many deaths are already recorded
because of sickle cell disease so knowing the risks of curing it can help prevent further
complications and presenting the root cause of the complications can help the people understand
more.

Reference:
Woldie, I., Swerdlow, P., Bluth, M., Mohammad, U., Landolfi, E., Chaudrhy, S., . . . O'Malley, B.
(2015). Lifetime risk and characterization of red blood cell alloimmunization in chronically
transfused patients with sickle cell disease. International Journal of Blood Transfusion and
Immunohatology, 5, 1-5. doi:10.5348/ijbti-2015-15-OA-1