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October 2, 2018
NASDAQ: MNKD
©2018 MannKind Corporation. All rights reserved. No copying or distribution of this material may be made without written consent of MannKind Corporation.
Cautionary Statement
Today’s presentation includes forward-looking statements
relating to the development, commercialization and benefits
of our products and investigational product candidates,
including AFREZZA®, that are subject to certain risks and
uncertainties that could cause actual results to differ
materially from those projected herein. The words "believe,"
"expect," "intend," "anticipate," "plan," variations of such
words, and similar expressions identify forward-looking
statements, but their absence does not mean that a
statement is not forward-looking. These forward-looking
statements are not guarantees of future performance and
are subject to certain risks, uncertainties, and assumptions
that are difficult for us to predict and include, without
limitation, our ability to generate significant product sales,
our ability to manage our existing cash resources or raise
additional cash resources, stock price volatility and other
risks detailed in MannKind’s filings with the Securities and
Exchange Commission. For detailed information about the
risks and uncertainties that could cause actual results to
differ materially from those implied by, or anticipated in,
these forward looking statements, please refer to our current
and periodic reports filed with the Securities and Exchange
Commission from time to time, including our annual report
on Form 10-K for the year ended December 31, 2017.
2
Platform Technology:
Corporate Overview Technosphere particles enable drug molecules to be
delivered efficiently through the lungs
Founded in 1991, biopharma company focused
on inhaled therapeutic products for diabetes and Technosphere Pipeline:
pulmonary arterial hypertension (PAH)
• Treprostinil (TreT): Partnered with United Therapeutics upon
FTC clearance
Danbury, CT Westlake Village, CA • Approved for adults with diabetes in the US and filed in Brazil
R&D and Manufacturing Corporate Headquarters
>300,000 Sq Ft
• Addresses a large global population >400 Million people
Previously served as a Global VP Previously served as VP and CFO for Previously was in a series of senior sales Over 30 years in diabetes and metabolism
Lifecycle Management and Commercial Stryker’s International Group and compliance leadership roles at research, clinical management, research,
Lead for biosimilar portfolio at Amgen Astellas Pharma and policy advocacy
Prior to Stryker, served in a series of
Prior to Amgen, served in a variety of senior leadership roles at Bristol-Myers Prior to Astellas, held a sales leadership Most recently, served as Research
executive and commercial roles at BMS, Squibb role at Yamanouchi Pharma Physician and VP of Global Medical
Novartis, EMD Serono, DuPont and Affairs for Lilly Diabetes and prior to Chief
PharaAsset. Received a BA from Muhlenberg College Received an MBA from Kellogg School of Scientific and Medical Officer at the
Management, JD from South Texas American Diabetes Association
Received a BS from Philadelphia College Certified Public Accountant College of Law Houston and a BA from
of Pharmacy, Doctorate from MCPHS and Notre Dame Received his MD at University of
MBA from Wharton Business School Minnesota and a BA in Biology from St.
Olaf College
©2018 MannKind Corporation. All rights reserved. No copying or distribution of this material may be made without written consent of MannKind Corporation.
MannKind R&D Platform: Innovative Oral Inhalation Technology
Powder
Devices
Formulations
Digital Technology
5
Technosphere – Innovative Oral Inhalation Platform
Targeting Pulmonary Delivery of Therapeutic Agents
Rapid drug exposure – similar to I.V. Small Molecules, peptides and biologics
Avoids first pass liver metabolism Local drug delivery for lung disease
Consistent dose to dose delivery Systemic delivery for vaccines
Patient-focused
Business Advantages
Design
MannKind’s dry powder formulations with our proprietary inhalation devices ensure
successful drug delivery in first in human studies
STRICTLY CONFIDENTIAL 6
TECHNOSPHERE® PARTICLES: WHAT ARE THEY?
O O
H
HO
N
HN
O CRYSTALLINE
O HN
N
OH PARTICLE
H
O O
1000
100
AMORPHOUS
SOLUBILITY (mg/mL)
10 PARTICLE
1
0.1
0.01
0.001
0 2 4 6 8 10 12 1µm
pH
8
MannKind Innovative Inhalation Delivery Devices
Re-usable
Dreamboat®
Family
Single Use
Cricket® Family
©2018 MannKind Corporation. All rights reserved. No copying or distribution of this material may be made without written consent of MannKind Corporation.
We Have Redefined Our Filter for Development Candidates
11
Large Target Market
Over 20 million people in target patient population in US / >400M Globally
Approximately 1.25 million American children and adults have Type 1 diabetes
Over 20 million adults have Type 2 diabetes (95% of all people living with diabetes)
01 02 03 04 3+ OADs /05 06
1 Oral Pill / day 2 Oral Pills/ day day Oral or GLP-1 +
Diagnosis Diet & Exercise 3+ Oral Pills / day
(Metformin) or Oral w / GLP- Insulin or Insulin Only
1
Insulin Patients Achieving A1C Goals(1) Importance of Mealtime Control (PPG) for A1C(2)
100% 100%
90% 90%
> 9% FPG
80% 80%
55% 50% 30% PPG
70%
8 to 9% 70% 60%
% of Subjects
70%
60% 7 to 8% 60%
70%
Insulin Patients Achieving A1C Goals(1)
50% <7% 50%
50%
40% 40% 45%
40%
30% 30%
30%
20% 20%
10% 10%
0% 0%
<10.2 10.2 – 9.3 9.2 – 8.5 8.4 – 7.3 <7.3
A1C Range
Diabetes Care 2016 Mar; 39(3): e33-e35. https://doi.org/10.2337/d c15-2229 (2) Monnier L, et al. Diabetes Care. 2003;26:881-885 14
New STAT Data: Afrezza Started to Decrease Sugars in First 30
Minutes
Aspart Rx Afrezza Rx
195
185
Glucose (mg/dL)
175
165
30.2 31.7
28.8
10.1 11.5
8.6
2.9 2.9
0
Time in Hypoglycemia <70 mg/dL Time in Hypoglycemia <60 mg/dL Time in Hypoglycemia <50 mg/dL
16
Afrezza Business Continues to Build and Grow
Weekly Cartridge Sales Exceeding 110,000 per week
130,000
110,000
MannKind
Sales Team
Launched
90,000
70,000
50,000
30,000
10,000
1/6
1/20
2/3
2/17
3/3
3/17
3/31
4/14
4/28
5/12
5/26
6/9
6/23
7/7
7/21
8/4
8/18
9/1
9/15
9/29
10/13
10/27
11/10
11/24
12/8
12/22
1/5
1/19
2/2
2/16
3/2
3/16
3/30
4/13
4/27
5/11
5/25
6/8
6/22
7/6
7/20
8/3
8/17
8/31
9/14
2017 2018
MannKind
Sales Team TRx Writer Count TRx Share
Launched
4.5% 1,200
4.2%
4.1%
4.0% 4.0%
3.9% 3.9%
4.0% 3.8% 3.8% 3.8% 3.8% 1,000
3.7%
3.6%
Afrezza Market Share
3.5%
3.4%
3.5% 3.3% 3.4% 800
Writer Count
3.2%
3.1% 3.2% 3.1%
3.0% 600
2.5% 400
2.0% 200
1.5% -
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Jan Feb Mar Apr May Jun Jul Aug
2017 2018
Market: Admelog, Afrezza, Apidra, Fiasp, Humalog, Novolog
Writers: HCPs with 1+ Afrezza TRx within measurement month Source: Symphony Prescriber Data 18
Diabetes Care is Quickly Incorporating Feedback Loops and Digital
Integration
CLICK TO RESTART
19
©2018 MannKind Corporation. All rights reserved. No copying or distribution of this material may be made without written consent of MannKind Corporation. 19
United Therapeutics Collaboration Details
20
TREPROSTINIL (TreT) Cmax*: Well Tolerated to 150mcg
4000
3500
3000
2500
Cmax (pg/mL)
TreT
2000
Tyvaso
1500
1000
500
0 0 50 100 150 200
54 mcg dose (mcg)
Approved dose
475 32
>780 PROVIDE PROTECTION
to Afrezza® and related
technologies
U.S. PATENTS listed in
FDA’s Orange Book with
Afrezza NDA
TOTAL PATENTS
in force
worldwide
51 >300
>610 >170 U.S. PATENTS
listed in Afrezza’s Patent
Notice related to product
PENDING
Patent applications worldwide
in various technologies
Issued Issued markings
UTILITY DESIGN
patents patents
STRICTLY CONFIDENTIAL 22
Near Term Milestones and Key Events
The Foundation for Long-term Growth (as communicated September 2017)
✓ Completion of STAT Trial (Afrezza+Dexcom) – ADA Presentation & Publication (June 2018, September 2018)
✓ IND Filed for Technosphere Treprostinil (partnered with UTHR September 2018)
✓ International Expansion – BIOMM (Brazil, May 2017), Cipla (India, May 2018)
US Afrezza
Technosphere Platform
24
Thank You
Rose Alinaya, SVP Investor Relations
IR@mannkindcorp.com
©2018 MannKind Corporation. All rights reserved. No copying or distribution of this material may be made without written consent of MannKind Corporation.