Ameba

Solutions from the earth. For a better planet. Mark Benedyk, PhD
Executive Director
mbenedyk@amebagone.com
© 2018 AmebaGone, Inc. 858.354.6013
 Ameba Company Summary
Sustainable solutions for bacterial crop disease
• Founded in 2010: Microbial biocontrol platform
• $3.3 M in non-dilutive funding raised to date
• $10M Series A for platform and two products
 AmebaGoneSR for Potato soft rot
 AmebaGoneFB for Non-citrus fruit fire blight
• Replace
 Copper formulations
− Most common pesticide residue in organic food
− Pathogen resistance already globally prevalent
 Antibiotics
− Eliminate contribution to antimicrobial resistance
− Pathogen resistance already globally prevalent

2 © 2018 AmebaGone, Inc.

 The Problem: Bacterial Plant Disease
415M tons of potatoes produced globally in 2016
75M tons of potatoes lost annually to a single disease
5.4M acres of land wasted every year
5.1T gallons of water, 4.4M tons of fertilizer wasted every year

Globally 200,000 tons/yr of copper salts used on crops

Copper Toxic to humans & waterway pollutant
Bacterial resistance to copper globally prevalent

100 tons/yr of antibiotics on US crops

Antibiotics Toxic to humans & waterway pollutant
Bacterial resistance to antibiotics globally prevalent

3 © 2018 AmebaGone, Inc.

 Re-Tasking Amoebas to Clear Infection

Spores Germinate to Amoebas Hunt Harmful Bacteria

Amoebas Harmful Bacteria Digested & Killed

4 © 2018 AmebaGone, Inc. © 2018 AmebaGone, Inc.

 Dictyostelium Hunting Bacteria

• Natural predators of bacteria

• Planktonic and biofilm bacteria targeted
• Soil and leaf microbiome resident
• Amoebas detect and consume bacteria
• Starvation → Amoeba fusion → Spore
• Spore stage is the pre- and post-harvest inoculant

5 © 2018 AmebaGone, Inc.

 3,000 Global Strains: Multiple Applications

6 © 2018 AmebaGone, Inc.

 Key Driver: Organic Food Mkt Growth

$47B in organic produce in 2016 $135B

80% of market in NA & EU

80% organic sales in 10 US states

14,000 US organic farms

0.7% of the 2.1 M US farms

LARGE: Global biocontrol market TAM = $3.3B

SIGNIFICANT: Microbials 63% of market: 17% CAGR to 2025
GROWING: Market to $11B by 2025: climate change is driver

7 © 2018 AmebaGone, Inc.

 US Market: AmebaGoneSR & AmebaGoneFB
AmebaGoneSR : Potato Soft Rot
• Potatoes
• 1 US crop, $4.0B value (2016)
• 0.92M acres planted in US (2016)
• 22.1M tons annual harvest (2016)
• 4M tons lost to soft rot (2016)
• Application pre- & post-harvest
• Increasing incidence
• Discussion w/ key US potato grower
8 © 2018 AmebaGone, Inc.
AmebaGoneFB : Fire Blight
• 12 species of non-citrus fruit
• 10 key US crops, $6.12B value (2016)
• 0.65M acres planted in US (2016)
• 8.4M tons annual harvest (2016)
• 1-3M (est) tons lost to fire blight (2016)
• Application pre-harvest
• Increasing incidence
• Discussion w/ key MX apple grower
© 2018 AmebaGone, Inc.
 1st Gen AmebaGoneFB vs. Apple Fire Blight
2.3%
α-AmebaGoneFB

0.5%
Streptomycin

1.1%
Kasugamycin

12.6%
AG Vehicle

18.9%
Water

0.0% 5.0% 10.0% 15.0% 20.0% 25.0%

% Blighted Floral Clusters
Source: AmebaGone internal field trial data, supported by NSF SBIR Phase II # 1534650

9 © 2018 AmebaGone, Inc. © 2018 AmebaGone, Inc.

 $10M Series A Use of Proceeds (x$1000)
Regulatory $210
2%
G&A $2,344
24%
Mfg $1,965
20%

Legal $340
4%

Consultants $660
Field Trials $1,875 7%
20%

R&D $2,204
23%

10 © 2018 AmebaGone, Inc.

 Go-to-Market Strategy to Drive Value
2 products & 1 partnership by 2020
Manufacturing & regulatory roadmap for multiple products
In discussions with leading apple and potato growers

Focus on top 10 plant diseases caused by 8 classes of bacteria

Build on $3.3M in non-dilutive grant funding to date
Expand IP portfolio from current 3 issued and 2 pending patents

Platform: monetize non-strategic applications

Build balance sheet and opex with non-dilutive partner revenue
License products to key strategic partners and distributors

11 © 2018 AmebaGone, Inc.

 Executive Team

LEADERSHIP

Mark Benedyk, PhD Marcin Filutowicz, PhD Lynne Rollins

Executive Director Founder, President & CSO CFO

SUPPORT

ADVISORS

Andy Renz, Dr. rer. nat. Leslie Hickle, PhD Bill Domann

12 © 2018 AmebaGone, Inc. © 2018 AmebaGone, Inc.

 Scientific Advisory Board

LEADERSHIP

Marcin Filutowicz, PhD

Chair, Scientific Advisory Board

SUPPORT

ADVISORS

Amy Charkowski, PhD Amanda Gevens, PhD Patty McManus, PhD

13 © 2018 AmebaGone, Inc. © 2018 AmebaGone, Inc.

 Ameba

Solutions from the earth. For a better planet. Mark Benedyk, PhD
Executive Director
mbenedyk@amebagone.com
© 2018 AmebaGone, Inc. 858.354.6013