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Aminoglycosides Ototoxicity
Nephrotoxicity
Pyrazinamide Hyperuricemia
APLASTIC Chloramphenicol
Phenytoin
ANEMIA Quinine
Carbamazepine
Felbamate
Phenylbutazone
PTU
Benzene
Asparaginase ALLeukemia
A dopamine agonist
Chloramphenicol Alternative drug for Typhoid fever Gray baby syndrome: because
of lack of glucuronyl transferase
Aplastic anemia (hypoplastic
bone marrow filled with fat)
Optic neuritis
Bone marrow suppression
Blocks the 50s ribosomal subunit
Cromolyn sodium Prototype of mast cell stabilizers used to treat the s ymptoms of a
condition called mastocytosis, which
can cause diarrhea, nausea,
vomiting, headaches, stomach pain,
itchy skin, and flushing (warmth or
redness under the skin)
Chemotherapy: leukemia,
hodgkin’s lymphoma, bladder
cancer
DIHYDROFOLATE Methotrexate
Trimethoprim
REDUCTASE Pyrimethamine
INHIBITOR Proguanil
Sulfasalazine
JPC-2056 (an experimental
antimalarial)
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DISULFIRAM-LIKE Metronidazole
st
Tolbutamide (1 gen sulfonylurea)
REACTION Cefoperazone
Cefotetan
Griseofulvin
Temposil
Alopecia
Gangcyclovir Cytomegalovirus
Oxide
Lamivudine Hepatitis B
Lidocaine Local and regional anesthetic It is acidic; therefore, does not work
in an acidic environment (e.g.
Lidocaine + Epinephrine: abscess)
For vasoconstriction ↓bleeding,
↓washing out of lidocaine ↑effect Lidocaine duration of action: 30-60
minutes
w/ Epinephrine: up to 4 hours
Ocreotide Acromegaly
OTOTOXICITY Aminoglycosides
Furosemide
Cisplatin
Streptom ycin
st
1st line drug for Migraine also Ergotamine or Sumatripan
SLE-LIKE INH
Methyldopa
SYNDROME Hydralazine
Procainamide
Statins Myositis
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PHARMACOLOGY
CYCLOPENTANOPERHYDROPHENANTHRENE: the carbon skeleton found in
steroids (uncountable). The steroid nucleus.
Which of the following is the drug of choice for complex partial seizures?
Carbamazepine
Which of the following drugs is not used as a treatment for Acute gouty arthritis?
Ans. Allopurinol (is for chronic gout)
Podophyllotoxin – Etoposide
In a patient with arthritis taking aspirin Tc fo anticoagulant for M.I leads to: no interaction
Actinomycin D.- can also be used in W ilm’s Tumor in combination with Vincristine
Vitamin C is administered with what drug to acidify urine & enhance drug
effect: Methenamine
Advantage of Fentanyl over Morphine: Fentanyl has 80x analgesic potency than
Morphine
Methamphetamine is a: stimulant
Longest -Acting anti-hyper glycemic drugs: Chlorpropamide (36 hrs. half life)
This insoluble starch is used in cases of portal HPN and hepatic encephalopathy due to
decrease intestinal absorption of ammonia transformed into ammonium
acidification of urine: Lactulose
This anticancer is also useful in the treatment of rheumatoid arthritis; its adverse effects
can be reversed by administration of leucovorin: methotrexate