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NASCOP
The preliminary findings from Botswana identified 4 babies born with a neural
tube defect among 426 women who got pregnant while taking DTG. This neural
tube defect rate is approximately 0.9 percent, compared to a rate of 0.1 percent
among women who became pregnant while taking non-DTG-based regimens.
European Cohorts3
• 3/42 congenital abnormalities; no NTD
NASCOP September 2018
2. Antiretroviral Pregnancy Registry Interim Report, Dec 2017; 3. Thorne, IAS Conference 2017
NEURAL TUBE DEFECTS
22 -26 day old embryo
Anencephaly
Spina Bifida
• Other points
• Exclude pregnancy before starting DTG (EMA, FDA, SAHCS)
• If pregnancy is confirmed in the first trimester, switch to a non-DTG
containing regimen (EMA, SAHCS)
NASCOP September 2018
VIRAL LOAD MONITORING