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Milk thistle is a powerful and safe herb for liver support. Its extract (silymarin) boosts detox, lowers
inflammation, and increases antioxidant defense, which is beneficial for liver and gallbladder issues,
diabetes, and autoimmune diseases. Read on to learn more, along with dosage information and smart ways
to improve the poor bioavailability of its active compound silybin.
CONTENTS [HIDE]
Milk Thistle Snapshot
What is Milk Thistle (Silymarin)?
The Health Benefits of Milk Thistle
Milk Thistle Synergies
Milk Thistle Dosage & Forms of Supplementation
Milk Thistle Safety and Side Effects
Buy Milk Thistle
Caveats and Limitations
Pros
Cons
Milk thistle (Silybum marianum) is a medicinal plant that belongs to a large family of flowering plants
(Asteraceae). It has been used traditionally for thousands of years as a “liver elixir” for a variety of
diseases to do with liver dysfunction or gallbladder problems. It was also used to protect the liver
against snake poison, insect stings, mushroom poisoning, and alcohol abuse [R, R, R].
Milk thistle is a relative of dandelion and regular artichoke. Sometimes it’s called “wild artichoke”. It’s
native to Southern Europe, Russia, Asia, and Africa and is now also cultivated throughout the world. The
seed-like fruits of the plant are used medicinally. Traditionally, though, the leaves were used in salads
and the fruit of the flower roasted as a coffee substitute [R, R, R].
Silymarin is a mix of active components that are highly concentrated in a standardized extract of
milk thistle seeds [R].
In the US, milk thistle is among the most popular herbal supplements. It’s also commonly used in other
parts of the world, especially in Germany — the largest producer of milk thistle (Madaus). The German
Scientific Board recommends its use for indigestion, toxin-induced liver damage, cirrhosis, and liver
inflammation [R, R, R].
Although more studies are needed, milk thistle is a great example of traditional plant knowledge being
successfully put to scientific scrutiny. Since the 1970s, milk thistle extracts and its main active component
(silybin) have been regarded as an official medicine for liver diseases [R].
Numerous high-quality clinical trials have investigated the health benefits of milk thistle in the 21st
century; over 70 human studies in total have been published so far. This article will take you through all
the latest scientific findings and their health implications.
Silymarin makes up to 3% of the dry fruit, while fruit extracts can have up to 80% [R].
Silymarin is a complex mixture of flavonoid complexes that includes [R]:
Since silybin is the main active compound of this mixture, most milk thistle supplements are
measured by how much of it they contain [R, R].
Silybin concentrations in various extracts can vary:
Tip: Don’t get confused when you look at the supplement label. Remember: Milk thistle extracts should be
high in silymarin (60-80%) and a large part of this silymarin complex should be silybin (at least 20% but
aim for those with 50-70%)!
However, silymarin has poor bioavailability (check the dosage section for ways to overcome this) . Plus,
absorbed silymarin is broken down and transformed into inactive metabolites in the liver. Most of it is
eliminated through bile, together with bile acids [R].
A combination of Milk thistle’s active compound, Silybin, phosphatidylcholine, and vitamin E over 1
year improved non-alcoholic fatty liver disease (NAFLD) in a clinical trial of 179 people. It reduced
liver enzymes, insulin resistance, and liver scarring with no serious side effects. Some of the included
Hepatitis C+ participants included in the trial experienced the same benefits [R, R].
However, the active ingredients can reach higher blood levels in people just with fatty liver disease than in
those with Hepatitis C. After being absorbed, silybin is secreted into the gut with bile. People with
Hepatitis C can’t absorb silybin again and “recycle” it, which lowers its blood concentration [R].
Overall, silybin from milk thistle improves fatty liver disease, even in people who also have Hepatitis C.
But those with Hepatitis C may need higher doses (2.1g/day of silybin) to compensate for the liver damage
that affects bioavailability [R].
Hepatitis C and B
An analysis of over 1k people concluded that people with hepatitis B or C who took milk thistle are less
likely to die of liver-related issues [R].
In an observational study of over 1000 people with hepatitis C, those with the more severe forms of the
disease who used silymarin were less likely to experience worsening and further liver damage (cirrhosis)
[R].
In one clinical trial of 36 people with hepatitis C who didn’t respond just to drugs (Peg interferon +
ribavirin), IV silybin alone or as an add-on to the anti-Hep C drugs greatly reduced viral activity and
load. In 7 people, the virus became completely undetectable after 6 weeks (15-20 mg/kg) [R].
However, in another trial of 154 people with Hepatitis C who previously didn’t respond to standard therapy
(interferons), oral silymarin (2.1g/day) did not lower liver enzymes or virus activity much after 6 months.
But the researchers didn’t measure the silybin content in the extract, blood levels of its active components,
nor focus on the virus load [R, R].
According to an analysis of almost 400 people, oral silymarin has modest effects on reducing the activity of
the Hepatitis C virus, not much different from the placebo. Silybin, the active ingredient, may work better
if given through a high-dose IV in people with Hepatitis C, but further studies are needed [R].
People with liver disease often have very high ferritin levels due to liver inflammation and injury. In a
trial of 37 people with Hepatitis C, silybin combined with phosphatidylcholine reduced ferritin levels in
~80% of the cases over 12 weeks [R, R]
People with any Hepatitis virus can experience a sudden, acute worsening and liver inflammation. In a
clinical trial of 105 people such cases, silymarin (420 mg/day) reduced symptoms, improved jaundice and
bile flow over 4 weeks [R].
Milk thistle was active against Hepatitis C in many cellular studies. Silymarin blocks the Hepatitis C
virus from entering cells, infecting them, and dividing. But in this cellular study, it wasn’t active against
all strains of the virus, so some people may not respond to it [R, R].
In one cellular study, silybin protected from the HIV virus, reduced its activity and division. It also
reduced immune activation and inflammation that contributes to the spreading of HIV [R].
In an observational study of over 600 people, a water-soluble Silymarin extract (420 mg/day) over 11
months safely lowered high liver enzymes and bilirubinin those with alcoholic liver disease [R].
Silymarin (450 mg/day) increased the master antioxidant glutathione and reduced oxidative stress in red
blood cells in a clinical trial of 60 people with alcoholic liver disease after 6 months. It didn’t affect liver
function or enzymes in this study, though [R].
Milk thistle may protect the liver from drugs and toxins [R].
In animals, silymarin and silybin protected the liver against damage from alcohol, toxins (carbon
tetrachloride and thallium), chemotherapy drugs (cisplatin), Tylenol (acetaminophen),
radiation, iron overload, and the poisonous mushroom death cap (Amanita phalloides) [R+, R].
In a clinical trial of 50 children with leukemia, milk thistle protected the liver and reduced damage from
chemotherapy drugs after 1 month [R].
In a woman with leukemia, silymarin (800 mg/day) reduced the side effects of chemotherapy drugs and
protected the liver over 4 months [R].
Milk thistle doesn’t protect the liver from all drugs. For example, it didn’t protect the liver from anti-
tuberculosis drugs in a study of 380 people. On the contrary, it even slightly increased the risk of liver
damage [R]
Most mushroom poisonings worldwide are from a mushroom called “death cap”. Milk thistle is the number
1 antidote for death cap poisoning, given as IV silybin (oral silybin doesn’t work). It saved lives in over
90% of 1500 cases in the US, which is better than any other antidote. It should be given within 48h to
prevented severe liver damage and increase survival [R, R, R].
Quality of Life
In a survey of 32 people who received liver transplants, those who used milk thistle and other herbal
products had better problem-solving skills, considered the supplement investment worthwhile, and reported
better overall health [R].
This does not speak to the benefits of milk thistle, but shows that people who tend to take their health into
their own hands actively seek natural alternatives.
The combination with berberine improves metabolic syndrome and type 1 diabetes [R, R]
Berberine and Milk thistle added on to statins improved blood lipid levels [R].
Silybin with Vitamin E and Phospholipids work together to reduce chronic liver damage [R].
Milk thistle increases antioxidant defense in combination with Bacopamonnieri, Ashwagandha, N-
acetyl cysteine, Curcumin (turmeric extract), green tea extract, gotu-kola powder, Ginkgo biloba leaf
extract, Aloe verapowder [R].
A combination with garlic, Aloe vera, black cumin, Plantago psyllium, and fenugreek was used for
advanced type 2 diabetes [R]
Milk thistle with red yeast rice extract and octacosanol improved blood fats and inflammation [R]
Milk thistle was combined with selenium to improve prostate health [R, R]
To reduce menopausal symptoms, milk thistle was combined with black cohosh, dong quai, red
clover, American ginseng, and chaste-tree berry [R]
In Iberogast for indigestion, milk thistle is combined with bitter candytuft, chamomile flower, peppermint
leaves, caraway fruit, licorice root, lemon balm leaves, angelica root, and celandine herbs [R]
Milk thistle is considered a very safe herbal supplement. Standardized milk thistle extracts should contain
70-80 % Silymarin. Ideally, the the silybin content should also be mentioned and account for ~40% (the
higher the better).
The typical silymarin dosage used in most studies was ~420 mg/day divided into 2 or 3 doses.
In people with liver disease, the typical dosage is higher, around 1.3 g/day of the standardized for 6-8
weeks (divided into 3 doses during the day). For maintenance, the dose can be reduced to 280 mg/day [R].
Silymarin doses up to 2.1 g per day may need to be used in people with viral hepatitis, especially in those
with a chronic hepatitis C infection. Even so, IV silybin may work better than oral extracts in people with
serious liver damage [R].
Very high doses of the silybin IV solution are used for mushroom poisoning
Milk thistle appears to be safe even if used daily for over 3 years. In cancer patients, the highest safe dose
was about 13 g/day. [R].
Milk thistle is available in many forms as a supplement. Milk thistle supplements, including silymarin
extracts, include all the following:
Capsules
Tablets
Tinctures
Intravenous solutions.
Milk thistle has a bitter taste, which you will notice if you take it as a tincture. This helps if you’re taking it
for indigestion but can be unpleasant otherwise.
Some people consider that taking organic milk thistle has additional benefits. Organically-grown plants
sometimes have higher concentrations of bioactive compounds, but this has not been confirmed for milk
thistle. It’s more important to make sure the supplement you decide to buy is standardized to the active
ingredients.
Berberine increases the bioavailability of silybin and the two act together in synergy [R]
Other flavonoids (such as quercetin) increase its absorption [R]
Fats, proteins, amino acids, and cholesterol increase its absorption [R]
Vitamin E helps dissolve silybin and increases bioavailability [R]
Soluble water extracts
Silymarin complexes with phospholipids like phosphatidylcholine (SIliphos)
Liposomal silymarin
Nano-silymarin or nano-silybin [R]
Purified extracts from the fruit [R]
Mixing it into small particles (micelles) with bile salts [R]
Soft gels [R]
Advanced formulations (microemulsions or solid dispersion systems)
Modifying silybin by binding it to sugars to make it water-soluble (still in the research phase) [R+]
Milk thistle and its active component silymarin is a safe herbal product as long as the researched doses are
not surpassed.
The main adverse effects reported are [R, R, R].
Drug Interactions
Although milk thistle generally safe, not much is known about its food and drug interactions [R].
Although some cellular studies found that it may affect CYP enzymes in the liver that metabolize
drugs, human studies show it doesn’t have a large enough effect to trigger drug interactions [R]
Milk thistle is probably safe to use in HIV positive people with Hep C alongside other medications (such as
darunavir, ritonavir, and indinavir) [R, R, R].
It doesn’t affect nifedipine, used in people with heart disease, digoxin used for heart failure, or antibiotics
[R, R, R]
Some animal studies suggest it may increase the effects of anti-seizure medications. Exercise caution and
consult your doctor if you are taking anti-seizure drugs or have epilepsy [R, R].
Amazon or iHerb
Although there is a fair amount of good quality clinical trials, more research is still needed to confirm many
of the listed benefits. Bioavailability was a big issue in some studies, especially in cases of disease when
high levels of the active compounds need to reach the blood. Intravenous silybin was used at times, which
can’t be considered the same as taking the regular oral supplements. Some studies were only done in
animals or in cells.
FDA Compliance
The information on this website has not been evaluated by the Food & Drug Administration or any other
medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is
shared for educational purposes only. You must consult your doctor before acting on any content on this
website, especially if you are pregnant, nursing, taking medication, or have a medical condition.
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JOE
COHEN
CEO, SelfHacked
About Joe
Growing up, Joe was plagued with a myriad of health issues such as gut problems,
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conventional and alternative doctors weren’t able to help him, so he decided to fix himself.
With lots of health questions and few satisfying answers, Joe decided to read every research
paper he could get his hands on and conduct thousands of experiments on his own body in
order to fix his health issues. Joe started SelfHacked in late 2013 when he successfully fixed
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