ACCELRYS

ABOUT ACCELRYS

Accelrys (NASDAQ: ACCL) is a software company headquartered in the San Diego, California,
USA with representation in Cambridge, UK, Europe and Tokyo, Japan. It provides software for
chemical research, especially in the areas of drug discovery and materials science. A global
company and a leader in innovation, Accelrys develops scientific business intelligence software
and solutions, ELN’s & modeling/simulation software for the life sciences, energy, chemicals,
aerospace, and consumer products industries.

Accelrys started in 2001 from the fusion of five companies: Molecular Simulations Inc. (MSI,
itself a result of the combination of Biodesign, Cambridge Molecular Design, Polygen and, later,
Biosym Technologies), Synopsys Scientific Systems, Oxford Molecular, the Genetics Computer
Group (GCG), and Synomics Ltd.

In 2004, Accelrys acquired SciTegic, producer of the Pipeline Pilot software. On July 1, 2010,
the merger between Accelrys, Inc. and Symyx Technologies, Inc. was completed. Both the teams
are excited to come together as the leading scientific informatics software company. Their
combined solutions enable customers to improve scientific performance by creating more open,
flexible and agile environments, streamlining workflows, reducing operating costs and increasing
the potential for innovation.

ACTIVITES

Customers include many Fortune 500 companies and other commercial entities, as well as
academic and government entities. It has activities in various fields like:
Academic
Aerospace
Automotive
Biotechnology
Chemicals
Consumer packaged goods
Electronics
Energy
Government
Pharmaceuticals
Accelrys has a vast portfolio of computer-aided design modeling and simulation offerings which
assist customers in conducting scientific experiments 'in silico' in order to reduce the duration
and cost of discovering and developing new drugs and materials. Its scientific business
intelligence platform underlies the company's computer-aided design modeling and simulation
offerings. The Accelrys platform can be used with both Accelrys and competitive products, as
well as with customers' proprietary predictive science products. Its flexibility, ease-of-use and
advanced chemical, text and image analysis and reporting capabilities enable customers to mine,
aggregate, analyze and report scientific data from disparate sources, thereby better utilizing
scientific data within their organizations. Also Accelrys manages a Nanotechnology Consortium
producing software tools for rational nanodesign.
BIOTECHNOLOGY INDUSTRY
From creating better drugs to more productive crops, biotechnology companies deliver change
that propels markets forward. But for many companies, the technology that helps drive
innovation can sometimes hinder it. There is too much data to manage. Software programs and
databases are disconnected. Teams cannot easily share their findings. Newly available algorithms
are difficult to integrate into existing workflows. Previously garnered insight doesn't transition
into new projects. Accelrys offers you unparalleled opportunity for customizing an integrated
discovery platform that helps you overcome these challenges and drive your research to new
levels.

How Accelrys can help in these areas of bioscience research:

• Bioanalysis
• Biomarkers
• Biotherapeutics
• Genomics
• Protein Engineering
• Proteomics
• Systems Biology
• Translational Research

Accelrys product offerings for biotechnology research include the following:

Scientific Informatics Platform

Pipeline Pilot lets you graphically create complex scientific analysis and reporting workflows
that can be automated, reused and shared.
With Pipeline Pilot you can:
 • Uncover insights hidden in your data by integrating and analyzing data that is isolated in
different repositories or research groups.
• Perform advanced scientific analysis with a robust collection of algorithms and best-
practice protocols, such as those for Mass Spectrometry for Proteomics, Gene
Expression, Sequence Analysis, Image Analysis, R Statistics, and more.
• Save time by automating cumbersome data gathering, analysis, and reporting processes.
• Leverage cutting-edge approaches by integrating newly available third-party or in-house
algorithms without destroying existing workflows.
• Enforce best practices and enhance collaboration by sharing results, real-time reports and
dashboards, detailed workflows, and task-based procedures.
Learn more about Pipeline Pilot.

Life Science Modeling and Simulation

Discovery Studio delivers the advanced life science modeling and simulation tools you need, on
a platform that enables process automation, custom workflow creation, and integration of
disparate data types, databases, and third-party or in-house tools.
With Discovery Studio you can:
• Uncover new targets by developing 3D protein structures using homology/antibody
modeling and simulating potential interactions.
• Quickly identify promising leads with sophisticated structure-based, ligand-based, and
pharmacophore-based modeling tools.
• Spot potential problems early with ADME, toxicology and activity profiling tools.
• Optimize candidates with library design, QSAR, SAR, pharmacophore, and fragment-
based design tools.
Learn more about Discovery Studio.

Informatics
Accelrys Informatics Products let you capture, manage, analyze and mine large quantities of
research data and information, including data on chemical compounds and biological entities.
With Accelrys Informatics Products, you can:
• Overcome the challenges of registering biological entities such as antibodies, vaccines,
and small molecules.
• Successfully manage chemical inventory with an integrated system that enables fine-
tuned searching, experimental planning and execution, location of compounds, analogues
and reagents available for purchase, and integration with other systems (e.g., corporate
requisition systems and electronic laboratory notebooks).
 • Create a custom corporate registration system that provides secure and easy access to
compound data alongside supportive data (e.g., biological and property data), as well as
additional services such as 2D structure checking, enhanced visualization, property
calculation, and reporting and dashboarding functionality.
• Mine, store, federate, and search data using tools that enable cleaning of data,
normalization of chemistry used, improvement of stereochemistry information, addition
of properties, and fine-tuned searching across databases and data types with a high-
degree of specificity.
• Store and process HTS data, leveraging data from libraries used in the screen, images,
numerical data, lab notebook data, and experiment design and notes.
Learn more about Accelrys Informatics Products.

Drawing
Accelrys Draw lets you edit, visualize, compare, and explore biological sequences along with
chemical structures and reactions, improving multidisciplinary collaboration, IP management,
and R&D efficiency.
With Accelrys Draw, you can:
• Create 1- and 3-letter peptide, DNA, or RNA sequences
• Draw crossing bonds, disulfide bridges, and attach side-chain protecting groups
• Convert text into chemically-significant sequences
• Expand residues in a sequence to full structure to illustrate chemical modifications
• Manage your complex biological entities (when used in combination with the Accelrys
Direct data cartridge and the award-winning Accelrys Biological Registration system).
○ Register and retrieve molecules, reactions, and biomolecular sequences including
peptides, oligonucleotides, and oligosaccharides
○ Import sequence files from UniProt for viewing, editing, and interpretation
○ Mutate and modify residues using standard and custom libraries of modifications
○ Add custom residues and linkers, PEGylation, and natural/unnatural
lactone/lactam formations
○ Protect IP by registering modified sequences in a corporate database; perform
duplicate checking, exact matching, molecular weight calculation, and
substructure searching
Learn more about Accelrys Draw.
Electronic Laboratory Notebook
Symyx Notebook by Accelrys for Biology streamlines the capture of biological information and
processes, and improves collaboration with colleagues and contract research organizations, with
a flexible, enterprise Electronic Laboratory Notebook (ELN).
With Symyx Notebook by Accelrys for Biology, you can:
• Record unstructured (microscopy, gel images, blots, etc.) and structured data (Excel
sheets, graphs)
• Improve collaboration across multiple scientific disciplines—from research to final
product
• Enhance personal productivity
• Consolidate experimental data
• Minimize data errors
• Protect intellectual property (IP)
• Streamline regulatory compliance
• Implement consistent processes across organizations.
Learn more about Symyx Notebook by Accelrys for Biology.

Decision Support
Isentris provides a complete, out-of-the-box solution for searching, browsing, organizing, and
reporting on corporate, project, and personal information used by R&D organizations.
With Isentris, you can:
• Integrate information and applications into scientific workflows to improve R&D
productivity
• Develop and extend applications
• Integrate specialized tools and gain access to internal and external data sources
• Support workflow processes and strengthen decision making
Learn more about Isentris.

Lab Execution and Analysis

Accelrys Lab Execution and Analysis Software offers unparalleled, high-throughput and
experiment automation support for laboratories, combined with comprehensive data visualization
and analysis capabilities. With Accelrys Lab Execution and Analysis Software, you can increase
R&D productivity by:
• Repeating fewer experiments
• Predicting more and experimenting less
• Improving results by better design
 • Failing early
• Innovating
Learn more about Accelrys Lab Execution and Analysis Software.

Lab Operations
Accelrys Lab Operations Software is an integrated set of applications that enables scientists to
manage the chemical and biological aspects of the discovery process.
With Accelrys Lab Operations Software, you can:
• Build the corporate compound registry
• Manage reagent procurement
• Manage plate and sample information
• Leverage the content value
• Streamline workflows
• Enhance lab productivity
• Support laboratory "back office" operations
Learn more about Accelrys Lab Operations Software.

Database Content and Access Portals

Accelrys offer a comprehensive collection of databases and reference works that cover
bioactivity, chemical sourcing, molecular properties, synthetic methodology, metabolism, and
toxicology information, as well unparalleled ways to access that data and source compounds,
such as through the DiscoveryGate portal.

BIOINFORMATICS
Bioinformatics is at the heart of many areas of modern biology and offers great opportunity for
scientific advancement, particularly in systems biology and personalized medicine. The
applications are numerous: biomarker analysis, drug discovery, toxicology, health and wellness,
disease diagnosis and monitoring, food safety, and counter-bioterrorism. However, the
enormous volume of disparate data that must be analyzed, along with the frequent availability of
new analysis techniques, presents a data management and analysis challenge that can threaten
project success.
Accelrys’ software for bioinformatics enable you to:
• Easily access and manage scientific data scattered across your organization
• Access datasets from past experiments reducing unnecessary re-testing
• Leverage experience of lead bioinformaticians by sharing best practices across the
organization
Accelrys Biological Registration System
Streamline your processes and protect your IP with the market's first multi-entity, fully-
integrated system for registering, relationship-tracking, querying, and reporting on complex
biological entities. Built in close collaboration with top pharmaceutical companies, this award-
winning system has the power and flexibility needed to integrate within existing infrastructures
and adapt to your organization's changing needs.

LAB EXECUTION AND ANALYSIS OVERVIEW

Accelrys Lab Execution and Analysis (LEA) software provides a complete laboratory
informatics environment to support high throughput, parallelized and automated experiment
design, execution, analysis and reporting in life science and non-life science industries.
A suite of over 200 common instrument integration protocols supports scientists in automating,
integrating and linking laboratory hardware and capturing instrument data in a centrally
accessible and shareable information store. LEA software captures design information, real-time
run information and analytical results together in one place for easy reporting and fast analytical
decisions.

Benefits of LEA
• One stop laboratory informatics solution
• Parallel, array-based experiment design
• Automated execution of experiments
• Collection and manipulation of analytical data
• Flexible reporting across experiments
The following Accelrys lab execution software offers vendor-neutral interfaces to facilitate the
capture and processing of data from third-party instruments:
Accelrys Library Studio: Intuitive graphical environment for designing complex libraries and
automating a variety of experimental applications
Accelrys Automation Studio: Integrated, multi-instrument automation and experiment control
with real-time data collection and data processing
The following Accelrys experiment analysis/decision support software offers real-time data
processing and dynamic data access to laboratory-warehoused data.
Accelrys PolyView: Sample-based data query and visualization across experimental activities
Accelrys Spectra Studio: Spectral clustering, comparison and sample identification
In addition, Accelrys Assay Explorer provides a powerful, customizable, and extensible
biological data management solution for capturing, analyzing, and reporting biological
experiments.

LAB OPERATIONS OVERVIEW

The Accelrys Lab Operations suite of products focuses on providing objects, services and
applications designed to support efficient, streamlined laboratory operations and collaboration.
Together they provide all or part of a master data management and workflow orchestration
environment for operational efficiencies within R&D labs—an environment where scientists can
manage and track entities such as work requests, equipment, containers, samples and other
critical objects and workflows across multiple applications and locations.
The current Metrology and Work Request Lab Operations applications are Web-based and can
be integrated into existing laboratory environments or deployed as out-of-the-box, integrated
applications with the Accelrys Lab Execution and Analysis (LEA) suite or Symyx Notebook by
Accelrys. Additional Materials and Procurement modules are planned.

What you can do with Lab Operations

The benefits of the Lab Operations suite are compelling. For the research manager and
supporting staff, project tasks across the organization gain visibility and are tracked in one
system. Reporting and searching tools give an overview of ongoing activities while providing
easy access to test results.
For the scientist, the ability to assign tasks to others and track their status increases productivity
and provides support for cross-site/department workflows that are often bottlenecks in project
progress. Scientists have access to a wealth of information about activities and tests that have
been done by others, enabling them to leverage the organizational knowledge base and work
smarter.

Other benefits of Lab Operations

• Modules share the same object definition and service layer, which increases usability
• Flexible infrastructure and service-oriented architecture
○ Modular architectural elements
○ Install only the necessary modules
• Integrated out-of-the-box with Accelrys software such as Symyx Notebook by Accelrys
and the Accelrys LEA suite
• Lower total cost of ownership than traditional LIMS solutions
• Faster deployment and payback period
• Smaller, more manageable projects and roll-outs
DATABASES OVERVIEW
Accelrys databases accelerate scientific research by delivering unique answers to your chemical
sourcing, synthetic methodology, and bioactivity questions. By providing easy access to
integrated, cross-referenced data from multiple sources, Accelrys enables you to search and
explore comprehensive information, when and how you want, in the context of your laboratory
workflows - saving time, reducing costs, and enhancing decision confidence.
Accelrys provides access to a comprehensive collection of chemical sourcing, synthesis and
bioactivity databases enabling scientists to explore essential information including:
• Commercial sources of compounds
• Preparations of known compounds
• Synthetic pathways to new compounds
• ADME/Tox information
• Chemical safety requirements
• Competitive intelligence
Accelrys databases include sourcing, bioactivity and synthetic methodology information and are
available in different packages:
• Discovery Package for DiscoveryGate
• Synthesis Package for DiscoveryGate
• Pharmacology Package for DiscoveryGate
• Discovery Package for Isentris
• Synthesis Package for Isentris
• Pharmacology Package for Isentris
• Sourcing Package for Isentris
Database Access Overview
Accelrys supports information-driven R&D by delivering unique answers to molecular property,
chemical sourcing, synthetic methodology, bioactivity, and metabolism/ toxicology questions in
the context of laboratory workflows—saving time, reducing costs, and enhancing decision
confidence.
Accelrys content is accessible out-of-the-box through:
• DiscoveryGate
• DiscoveryGate Web Service
• Isentris Client
• ISIS Browsers
 • Accelrys Logistics
• Symyx Notebook by Accelrys
ACCELRYS & CORPORATE GOVERNANCE
They have the following committees in place:
1. Code of Business Conduct and Ethics
2. Corporate Governance and Nominating Committee Charter
3. Audit Committee Charter
4. HR Committee Charter
They also intend to disclose on their website any amendments that they make to, or waivers that
they grant from, the Code affecting their principal executive officers, principal financial officer
and principal accounting officer or controller, or persons performing similar functions that relate
to deterring wrongdoing or promoting:
• Honest and ethical conduct, including the ethical handling of actual or apparent conflicts
of interest between personal and professional relationships.
• Full, fair, accurate, timely and understandable disclosure in reports and documents that
we file with, or submit to, the SEC and in our public communications.
• Compliance with applicable governmental laws, rules and regulations.
• The prompt internal reporting of violations of the Code to an appropriate person or
person(s) identified in the Code; or Accountability for adherence to the Code.