Professional Documents
Culture Documents
Arellano - Cando
Digestion/Pancreatic secretions
Guyton & Hall (Chap 65, p.825)
Trypsin Inhibitor
- Formed in the glandular cells of the pancreas in order to prevent the activation of
trypsin and other digestive enzymes
- Pancreatic digestive enzymes must not be activated until they reach the small
intestine since their premature activation would digest the pancreas, and potentially
lead to acute pancreatitis
Digestion/Pancreatic secretions
Pancreatic Digestive Activated by Breaks Down
Enzyme
Phospholipase Phospholipid → FA +
phospholipids
Lack of water - temporary storage of enzymes in the acini & ducts until there is
fluid
2. Gastric
-nervous stimulation of enzyme secretion
- 5-10% of postmeal secretions
3. Intestinal
-Intestinal - large amounts of pancreatic secretion due to secretin
Cephalic and Gastric - little amounts of enzyme flow due to lack of fluid
Regulation
Secretin
-stimulates secretion of large amounts of bicarbonate ions
Bicarbonate → appropriate pH for pancreatic digestive enzymes (pH 7-8)
-released when pH is < 4.5-5
-pancreatic juice secretion (NaHCO3)
-Net result: HCl + NaHCO3 → NaCl + H2CO3
H2CO3 becomes CO2 and H2O
CO2 absorbed into the blood and expired through the lungs
NaCl in duodenum is neutralized
Regulation
Cholecystokinin (CCK)
- Stimulated by the presence of proteases, peptones, and long-chain fatty acids
in the upper small intestine
- Secreted by the I cells in the mucosa of duodenum and upper jejunum
- Result: increased secretion of pancreatic digestive enzymes by acinar cells
(70-80%)
Differences between pancreatic stimulatory effects of secretin and CCK
Regulation
Duodenum
-neutralization of acidic contents from the stomach
-blocking of peptic digestive activity of gastric juices