Top 15 Therapeutic 2008 PDF

SPECIAL REPORT NOVEMBER 2008
TOP 15
Therapeutic
GROUPs
What you will find in this special report
PharmaLive.com and Med Ad News editors present this

comprehensive listing of the top 15 therapeutic groups.
The therapeutic groups are presented in order determined by
the total number of products awaiting approval and in clinical
trials in the United States.
The lists for each therapeutic group detail:
• Product name
• Phase of development
• Disease/medical use
• Therapeutic category
• Developer/partner developer
Data provided by

TABLE OF CONTENTS
TOP 15 THERAPEUTIC GROUPS.......................................................................................3

CANCER..................................................................................................................4 to 34
CENTRAL NERVOUS SYSTEM...............................................................................35 to 45
INFECTIONS...........................................................................................................46 to 52
CARDIOVASCULAR..............................................................................................53 to 59
DIABETES AND METABOLIC DISORDERS............................................................60 to 63
PAIN/INFLAMMATION..........................................................................................64 to 67
RESPIRATORY........................................................................................................68 to 72
VACCINES.............................................................................................................73 to 75
GASTROINTESTINAL..............................................................................................76 to 79
OPHTHALMOLOGY..............................................................................................80 to 82
ARTHRITIS...............................................................................................................83 to 85
HEMATOLOGY......................................................................................................86 to 88
DERMATOLOGY...................................................................................................89 to 90
AUTOIMMUNE DISEASE.......................................................................................91 to 93
WOMEN’S HEALTH................................................................................................94 to 95

Top 15 Therapeutic GROUPs: Total Number of Products
(Awaiting approval and in clinical trials)
65 35
70
82
CANCER 635
635
82
CENTRAL NERVOUS SYSTEM 331
INFECTIONS 225
87
CARDIOVASCULAR 196
92 DIABETES & METABOLIC DISORDERS 153
PAIN/INFLAMMATION 133
97 RESPIRATORY 127
VACCINES 97
GASTROINTESTINAL 92
127
OPHTHALMOLOGY 87
ARTHRITIS 82
133 331 HEMATOLOGY 82
DERMATOLOGY 70
AUTOIMMUNE DISEASE 65
153
WOMEN’S HEALTH 35
196 225
Amongst the Top 15 Therapeutic Groups:
The combined total of products in the top 4 therapeutic groups (Cancer, CNS, Infections, and
Cardiovascular) account for 57.5% of all the drugs awaiting approval or in clinical-trials status
throughout the 15 therapeutic categories as of October 2008:
~ Cancer products in the pipeline account for 26.3%

~ Central Nervous System products comprise 13.7%
~ Infections products account for 9.3%
~ Cardiovascular products total 8.1%

TOP 15 THERAPEUTIC GROUPS: CANCER
Developer/partner
Product Phase Disease/medical use Therapeutic category
developer
131I-Labetuzumab Phase II clinical trials Colorectal cancer Cancer drugs Immunomedics Inc.
131I-TM-601 Phase II clinical trials Glioma Cancer drugs TransMolecular Inc.
131I-TM-601 Phase II clinical trials Melanoma Cancer drugs TransMolecular Inc.
1363089 Phase II clinical trials Gastric cancer Cancer drugs GlaxoSmithKline Inc.
1363089 Phase II clinical trials Papillary renal cell carcinoma Cancer drugs GlaxoSmithKline Inc.
1363089 Phase II clinical trials Head and neck cancer Cancer drugs GlaxoSmithKline Inc.
3F8 MAb Phase II clinical trials Neuroblastoma Cancer drugs United Therapeutics Corp.
3rd Generation Anti-CD20 Phase I clinical trials Chronic lymphocytic Cancer drugs Genentech Inc.
leukemia
3rd Generation Anti-CD20 Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Genentech Inc.
461364 Phase I clinical trials Cancer Cancer drugs GlaxoSmithKline Inc.
A-007 Phase II clinical trials Cervical intraepithelial Cancer drugs Tigris Pharmaceuticals Inc.
neoplasia
Abagovomab vaccine Phase III clinical trials Ovarian cancer Cancer drugs Menarini Group
ABI-008 Phase I/II clinical trials Hormone-refractory prostate Cancer drugs Abraxis BioScience Inc.
cancer
ABI-008 Phase I/II clinical trials Breast cancer Cancer drugs Abraxis BioScience Inc.
ABI-009 Phase I clinical trials Solid tumors Cancer drugs Abraxis BioScience Inc.
ABI-010 Phase I clinical trials Solid tumors Cancer drugs Abraxis BioScience Inc.
Abraxane Phase III clinical trials Non-small cell lung cancer Cancer drugs Abraxis BioScience Inc.
Abraxane Phase III clinical trials Ovarian cancer Cancer drugs Abraxis BioScience Inc.
Abraxane Phase III clinical trials Melanoma Cancer drugs Abraxis BioScience Inc.
Abraxane Phase III clinical trials Hormone-refractory prostate Cancer drugs Abraxis BioScience Inc.
cancer
Abraxane Phase II clinical trials Head and neck cancer Cancer drugs Abraxis BioScience Inc.
Abraxane Phase III clinical trials Pancreatic cancer Cancer drugs Abraxis BioScience Inc.
Abraxane Phase III clinical trials Breast cancer Cancer drugs Abraxis BioScience Inc.
ABT-263 Phase I/II clinical trials Chronic lymphocytic Cancer drugs Abbott Laboratories,
leukemia Genentech Inc.
ABT-263 Phase I clinical trials Lymphoid malignancies Cancer drugs Abbott Laboratories,
Genentech Inc.
ABT-263 Phase I clinical trials Small cell lung cancer Cancer drugs Abbott Laboratories,
Genentech Inc.
ABT-751 Phase II clinical trials Cancer Cancer drugs Abbott Laboratories
ABT-869 Phase II clinical trials Breast cancer Cancer drugs Abbott Laboratories,
Genentech Inc.
ABT-869 Phase II clinical trials Hepatocellular carcinoma Cancer drugs Abbott Laboratories,
Genentech Inc.
ABT-869 Phase II clinical trials Colorectal cancer Cancer drugs Abbott Laboratories,
Genentech Inc.
ABT-869 Phase II clinical trials Non-small cell lung cancer Cancer drugs Abbott Laboratories,
Genentech Inc.
ABT-869 Phase II clinical trials Renal cell carcinoma Cancer drugs Abbott Laboratories,
Genentech Inc.
ABT-888 Phase I clinical trials Cancer Cancer drugs Abbott Laboratories
AC220 Phase I clinical trials Acute myeloid leukemia Cancer drugs Ambit Biosciences Corp.
Acapodene Phase III clinical trials Prostate cancer Cancer drugs GTx Inc.
Actemra Phase II clinical trials Multiple myeloma Cancer drugs Chugai Pharmaceutical Co.
Actemra Phase I clinical trials Castleman’s disease Cancer drugs Chugai Pharmaceutical Co.

Developer/partner
developer
Adecatumumab Phase II clinical trials Metastatic breast cancer Cancer drugs EMD Serono Inc.,
Micromet Inc.
ADH-1 Plus Isolated Limb Phase I/II clinical trials Melanoma Cancer drugs Adherex Technologies Inc.
Infusion Melphalan
Advexin Phase II clinical trials Non-small cell lung cancer Cancer drugs Introgen Therapeutics Inc.
Advexin Awaiting approval Head and neck cancer Cancer drugs Introgen Therapeutics Inc.
Advexin Phase I clinical trials Bladder cancer Cancer drugs Introgen Therapeutics Inc.
Advexin Phase I clinical trials Ovarian cancer Cancer drugs Introgen Therapeutics Inc.
Advexin Phase I/II clinical trials Breast cancer Cancer drugs Introgen Therapeutics Inc.
Advexin Phase I clinical trials Prostate cancer Cancer drugs Introgen Therapeutics Inc.
Advexin Phase I clinical trials Brain cancer Cancer drugs Introgen Therapeutics Inc.
Advexin Phase I/II clinical trials Esophageal cancer Cancer drugs Introgen Therapeutics Inc.
AE37 Phase II clinical trials Breast cancer Cancer drugs Antigen Express Inc.
AE37 Phase I clinical trials Prostate cancer Cancer drugs Antigen Express Inc.
AE37 Phase I clinical trials Ovarian cancer Cancer drugs Antigen Express Inc.
AEG35156 Phase I/II clinical trials Pancreatic cancer Cancer drugs Aegera Therapeutics Inc.
AEG35156 Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Aegera Therapeutics Inc.
AEG35156 Phase II clinical trials Solid tumors Cancer drugs Aegera Therapeutics Inc.
AEG35156 Phase I/II clinical trials Leukemia Cancer drugs Aegera Therapeutics Inc.
AEG41174 Phase I clinical trials Acute myeloid leukemia Cancer drugs Aegera Therapeutics Inc.
Aezea Phase II clinical trials Acute myelogenous leukemia Cancer drugs Eleos Inc.
Aezea Phase II clinical trials Chronic lymphocytic Cancer drugs Eleos Inc.
leukemia
AEZS-112 Phase I clinical trials Solid tumors Cancer drugs AEterna Zentaris Inc.
AEZS-112 Phase I clinical trials Lymphoma Cancer drugs AEterna Zentaris Inc.
Afinitor Phase II clinical trials Solid tumors Cancer drugs Novartis
Pharmaceuticals Corp.
Afinitor Phase III clinical trials Pancreatic islet tumors Cancer drugs Novartis
Afinitor Awaiting approval Kidney cancer Cancer drugs Novartis
Afinitor Phase III clinical trials Carcinoid tumors Cancer drugs Novartis
Afinitor Phase III clinical trials Neuroendocrine tumors Cancer drugs Novartis
AFP-464 Phase I clinical trials Cancer Cancer drugs Tigris Pharmaceuticals Inc.
AGS-003 Phase II clinical trials Renal cell carcinoma Cancer drugs Argos Therapeutics Inc.,
Kyowa Hakko Kirin Co.
AGS-005 Phase I/II clinical trials B-cell chronic lymphocytic Cancer drugs Argos Therapeutics Inc.
leukemia
AGS-16M18 Phase I clinical trials Cancer Cancer drugs Astellas Pharma US Inc.
AGS-8M4 Phase I clinical trials Cancer Cancer drugs Astellas Pharma US Inc.
Al-850 Phase I clinical trials Breast cancer Cancer drugs Cephalon Inc.
ALB109564 Phase I clinical trials Cancer Cancer drugs AMRI
Alimta Phase III clinical trials Head and neck cancer Cancer drugs Eli Lilly and Co.
Alimta Awaiting approval Non-small cell lung cancer Cancer drugs Eli Lilly and Co.
Allovectin-7 Phase III clinical trials Metastatic melanoma Cancer drugs Vical Inc., AnGes MG Inc.
Alocrest Phase I clinical trials Solid tumors Cancer drugs Hana Biosciences Inc.
Alpharadin Phase I clinical trials Hormone-refractory prostate Cancer drugs Algeta ASA
cancer
ALS-357 Phase I clinical trials Melanoma Cancer drugs Advanced Life Sciences Inc.
ALT-801 Phase I/II clinical trials Solid tumors Cancer drugs Altor BioScience Corp.

Developer/partner
developer
Alvocidib Phase III clinical trials Chronic lymphocytic Cancer drugs Sanofi-Aventis
leukemia
ALXN6000 Phase I/II clinical trials B-cell chronic lymphocytic Cancer drugs Alexion Pharmaceuticals Inc.
leukemia
AMG 102 Phase II clinical trials Renal cell carcinoma Cancer drugs Amgen Inc.
AMG 102 Phase II clinical trials Glioblastoma multiforme Cancer drugs Amgen Inc.
AMG 386 Phase II clinical trials Renal cell cancer Cancer drugs Amgen Inc.
AMG 386 Phase II clinical trials Breast cancer Cancer drugs Amgen Inc.
AMG 386 Phase II clinical trials Ovarian cancer Cancer drugs Amgen Inc.
AMG 386 Phase II clinical trials Gastric cancer Cancer drugs Amgen Inc.
AMG 479 Phase II clinical trials Cancer Cancer drugs Amgen Inc.
AMG 479 Phase II clinical trials Ewing’s sarcoma Cancer drugs Amgen Inc.
AMG 655 Phase II clinical trials Cancer Cancer drugs Amgen Inc.
Amonafide dihydrochloride Phase II clinical trials Hormone-refractory prostate Cancer drugs ChemGenex
cancer Therapeutics Inc.
Amonafide dihydrochloride Phase II clinical trials Breast cancer Cancer drugs ChemGenex
Therapeutics Inc.
Amonafide dihydrochloride Phase II clinical trials Ovarian cancer Cancer drugs ChemGenex
Therapeutics Inc.
Amplimexon Phase II clinical trials Pancreatic cancer Cancer drugs AmpliMed Corp.
Amplimexon Phase I/II clinical trials Malignant melanoma Cancer drugs AmpliMed Corp.
Amrubicin Phase III clinical trials Small cell lung cancer Cancer drugs Celgene Corp.
ANA773 Phase I clinical trials Solid tumors Cancer drugs Anadys Pharmaceuticals Inc.
Angiocept Phase I clinical trials Cancer Cancer drugs Adnexus Therapeutics Inc.
Annamycin Phase I/II clinical trials Acute lymphocytic leukemia Cancer drugs Callisto Pharmaceuticals Inc.
Annamycin Phase I clinical trials Acute myelogenous leukemia Cancer drugs Callisto Pharmaceuticals Inc.
Anti-CD137 Antibody Phase I clinical trials Cancer Cancer drugs Bristol-Myers Squibb Co.
Anti-CD40 Phase II clinical trials Diffuse large B-cell lymphoma Cancer drugs Genentech Inc.
Anti-CD40 Phase I clinical trials Multiple myeloma Cancer drugs Genentech Inc.
Anti-CD40 Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Genentech Inc.
Anti-Cripto mAb Phase I clinical trials Solid tumors Cancer drugs Biogen Idec Inc.
Anti-IGF-1R Phase I clinical trials Solid tumors Cancer drugs Biogen Idec Inc.
Anvirzel Phase I clinical trials Cancer Cancer drugs Ozelle Pharmaceuticals Inc.
ANX-514 Phase I clinical trials Cancer Cancer drugs Adventrx
Pharmaceuticals Inc.
Anyara Phase III clinical trials Renal cancer Cancer drugs Active Biotech AB
AP24534 Phase I clinical trials Chronic myeloid leukemia Cancer drugs Ariad Pharmaceuticals Inc.
AP24534 Phase I clinical trials Hematological malignancies Cancer drugs Ariad Pharmaceuticals Inc.
Aplidin Phase II clinical trials Multiple myeloma Cancer drugs PharmaMar USA Inc.
Aplidin Phase II clinical trials Acute lymphoblastic Cancer drugs PharmaMar USA Inc.
leukemia
Apomab Phase II clinical trials Non-small cell lung cancer Cancer drugs Genentech Inc.
Apomab Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Genentech Inc.
Apomab Phase I clinical trials Colorectal cancer Cancer drugs Genentech Inc.
Apoptone Phase I/II clinical trials Hormone-refractory prostate Cancer drugs Hollis-Eden Pharmaceuticals
cancer Inc.
AQ4N Phase II clinical trials Acute lymphoblastic Cancer drugs Novacea Inc.
leukemia
Archexin Phase II clinical trials Renal cell carcinoma Cancer drugs Rexahn Pharmaceuticals
Armala Phase III clinical trials Renal cell cancer Cancer drugs GlaxoSmithKline Inc.
Armala Phase II clinical trials Non-small cell lung cancer Cancer drugs GlaxoSmithKline Inc.

Developer/partner
developer
Armala Phase I clinical trials Colorectal cancer Cancer drugs GlaxoSmithKline Inc.
Armala Phase II clinical trials Ovarian cancer Cancer drugs GlaxoSmithKline Inc.
Armala Phase II clinical trials Sarcoma Cancer drugs GlaxoSmithKline Inc.
Armala Plus Tykerb Phase III clinical trials Breast cancer Cancer drugs GlaxoSmithKline Inc.
Aroplatin Phase II clinical trials Colorectal cancer Cancer drugs Antigenics Inc.
Aroplatin Phase I clinical trials Solid tumors Cancer drugs Antigenics Inc.
Aroplatin Phase I clinical trials B-cell lymphoma Cancer drugs Antigenics Inc.
ARQ 197 Phase II clinical trials Solid tumors Cancer drugs ArQule Inc.
ARQ 197 Phase II clinical trials Pancreatic cancer Cancer drugs ArQule Inc.
ARQ 197 Phase I clinical trials Non-small cell lung cancer Cancer drugs ArQule Inc.
ARRY-380 Phase I clinical trials Cancer Cancer drugs Array BioPharma Inc.
ARRY-520 Phase I clinical trials Cancer Cancer drugs Array BioPharma Inc.
ARRY-520 Phase I/II clinical trials Acute myelogenous leukemia Cancer drugs Array BioPharma Inc.
ARRY-543 Phase I clinical trials Solid tumors Cancer drugs Array BioPharma Inc.
ARRY-543 Phase I clinical trials Breast cancer Cancer drugs Array BioPharma Inc.
ARRY-797 Phase I clinical trials Hematologic cancer Cancer drugs Array BioPharma Inc.
Arzoxifene Phase III clinical trials Breast cancer Cancer drugs Eli Lilly and Co.
AS1402 Phase II clinical trials Breast cancer Cancer drugs Antisoma Plc.
AS1409 Phase I clinical trials Renal cancer Cancer drugs Antisoma Plc.
AS1409 Phase I clinical trials Melanoma Cancer drugs Antisoma Plc.
AS1411 Phase II clinical trials Renal cancer Cancer drugs Antisoma Plc.
AS1411 Phase II clinical trials Acute myelogenous leukemia Cancer drugs Antisoma Plc.
AS1413 Phase III clinical trials Acute myeloid leukemia Cancer drugs Antisoma Plc.
AS602868 Phase I clinical trials Hematological malignancies Cancer drugs EMD Serono Inc.
ASA404 Phase III clinical trials Non-small cell lung cancer Cancer drugs Novartis
ASAP Phase II clinical trials Non-small cell lung cancer Cancer drugs Eli Lilly and Co.
ASAP Phase II clinical trials Melanoma Cancer drugs Eli Lilly and Co.
ASAP Phase II clinical trials Ovarian cancer Cancer drugs Eli Lilly and Co.
ASAP Phase II clinical trials Soft tissue sarcoma Cancer drugs Eli Lilly and Co.
ASP0265 Phase I clinical trials Prostate cancer Cancer drugs Astellas Pharma US Inc.
AT-101 Phase I/II clinical trials Prostate cancer Cancer drugs Ascenta Therapeutics Inc.
AT13387 Phase I clinical trials Cancer Cancer drugs Astex Therapeutics Ltd.
AT7519 Phase I clinical trials Solid tumors Cancer drugs Astex Therapeutics Ltd.
AT9283 Phase I/II clinical trials Hematologic cancer Cancer drugs Astex Therapeutics Ltd.
AT9283 Phase I clinical trials Solid tumors Cancer drugs Astex Therapeutics Ltd.
Atacicept Phase I clinical trials B-cell chronic lymphocytic Cancer drugs Merck Serono SA
leukemia
Atacicept Phase I clinical trials Multiple myeloma Cancer drugs Merck Serono SA
Atacicept Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Merck Serono SA
Atiprimod Phase I/II clinical trials Multiple myeloma Cancer drugs Callisto Pharmaceuticals Inc.
Atiprimod Phase II clinical trials Carcinoid tumors Cancer drugs Callisto Pharmaceuticals Inc.
ATN-161 Phase II clinical trials Malignant glioma Cancer drugs Attenuon LLC
ATN-224 Phase II clinical trials Multiple myeloma Cancer drugs Attenuon LLC
ATN-224 Phase II clinical trials Melanoma Cancer drugs Attenuon LLC
ATN-224 Phase II clinical trials Prostate cancer Cancer drugs Attenuon LLC
ATX-101 Phase I/II clinical trials Lipoma Cancer drugs Kythera
Biopharmaceuticals Inc.
AV-299 Phase I clinical trials Solid tumors Cancer drugs Schering-Plough Corp.

Developer/partner
developer
AV-299 Phase I clinical trials Lymphoma Cancer drugs Schering-Plough Corp.
AV-412 Phase I clinical trials Solid tumors Cancer drugs AVEO Pharmaceuticals Inc.
AV-951 Phase II clinical trials Metastatic renal cell Cancer drugs AVEO Pharmaceuticals Inc.
carcinoma
AV-951 Phase I clinical trials Solid tumors Cancer drugs AVEO Pharmaceuticals Inc.
Avastin Phase III clinical trials Hormone-refractory prostate Cancer drugs Genentech Inc.,
cancer Hoffmann-La Roche Inc.
Avastin Phase III clinical trials Ovarian cancer Cancer drugs Genentech Inc.,
Hoffmann-La Roche Inc.
Avastin Phase III clinical trials Glioblastoma multiforme Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Breast cancer Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Gastric cancer Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Non-small cell lung cancer Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Colon cancer Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Gastrointestinal stromal tumor Cancer drugs Genentech Inc.,
Avastin Phase II clinical trials Small cell lung cancer Cancer drugs Genentech Inc.,
Avastin Phase II clinical trials Multiple myeloma Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Renal cell cancer Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Diffuse large B-cell lymphoma Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials High-risk carcinoid Cancer drugs Genentech Inc.,
Avastin Phase III clinical trials Head and neck cancer Cancer drugs Genentech Inc.,
Avastin Plus Herceptin Phase III clinical trials Breast cancer Cancer drugs Genentech Inc.,
Avastin Plus Tarceva Phase III clinical trials Non-small cell lung cancer Cancer drugs Genentech Inc.,
AVE1642 Phase I clinical trials Solid tumors Cancer drugs Sanofi-Aventis
AVE1642 Phase I clinical trials Multiple myeloma Cancer drugs Sanofi-Aventis
AVE8062 Phase III clinical trials Sarcoma Cancer drugs Sanofi-Aventis
AVE9633 Phase I clinical trials Acute myelocytic leukemia Cancer drugs Sanofi-Aventis
AVI-4126 Phase I clinical trials Prostate cancer Cancer drugs AVI BioPharma Inc.
AVI-4126 Phase I clinical trials Breast cancer Cancer drugs AVI BioPharma Inc.
AVN944 Phase I clinical trials Hematological malignancies Cancer drugs Avalon Pharmaceuticals Inc.
AVN944 Phase II clinical trials Pancreatic cancer Cancer drugs Avalon Pharmaceuticals Inc.
AVN944 Phase II clinical trials Myelogenous leukemia Cancer drugs Avalon Pharmaceuticals Inc.
Avodart Phase III clinical trials Prostate cancer Cancer drugs GlaxoSmithKline Inc.
AVR118 Phase II clinical trials Cancer Cancer drugs Advanced Viral
Research Corp.
Axitinib Phase II clinical trials Lung cancer Cancer drugs Pfizer Inc.
Axitinib Phase III clinical trials Renal cell carcinoma Cancer drugs Pfizer Inc.
Axitinib Phase II clinical trials Thyroid cancer Cancer drugs Pfizer Inc.
Axitinib Phase III clinical trials Pancreatic cancer Cancer drugs Pfizer Inc.
Axitinib Phase II clinical trials Gastrointestinal cancer Cancer drugs Pfizer Inc.

Developer/partner
developer
Axitinib Phase II clinical trials Breast cancer Cancer drugs Pfizer Inc.
AZD0530 Phase II clinical trials Solid tumors Cancer drugs AstraZeneca
Pharmaceuticals LP
AZD0530 Phase II clinical trials Hematological malignancies Cancer drugs AstraZeneca
Pharmaceuticals LP
AZD1152 Phase I clinical trials Solid tumors Cancer drugs AstraZeneca
Pharmaceuticals LP
AZD1152 Phase I clinical trials Hematological malignancies Cancer drugs AstraZeneca
Pharmaceuticals LP
AZD2281 Phase II clinical trials Breast cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
AZD2281 Phase II clinical trials Ovarian cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
Pharmaceuticals LP
Pharmaceuticals LP
AZD4877 Phase II clinical trials Hematological malignancies Cancer drugs AstraZeneca
Pharmaceuticals LP
Pharmaceuticals LP
AZD6244 Phase II clinical trials Melanoma Cancer drugs AstraZeneca
Pharmaceuticals LP
AZD6244 Phase II clinical trials Non-small cell lung cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
Pharmaceuticals LP
AZD8055 Phase I clinical trials Range of tumors Cancer drugs AstraZeneca
Pharmaceuticals LP
Pharmaceuticals LP
Pharmaceuticals LP
Azedra Phase I/II clinical trials Malignant Cancer drugs Molecular Insight
pheochromocytoma Pharmaceuticals Inc.
Azedra Phase II clinical trials Neuroblastoma Cancer drugs Molecular Insight
Azixa Phase II clinical trials Glioblastoma multiforme Cancer drugs Myriad Pharmaceuticals Inc.
Azixa Phase II clinical trials Melanoma Cancer drugs Myriad Genetics Inc.
Azixa Phase II clinical trials Non-small cell lung cancer Cancer drugs Myriad Genetics Inc.
Bavituximab Anti-Cancer Phase II clinical trials Breast cancer Cancer drugs Peregrine
Bavituximab Anti-Cancer Phase II clinical trials Solid tumors Cancer drugs Peregrine
Bavituximab Anti-Cancer Phase II clinical trials Non-small cell lung cancer Cancer drugs Peregrine
Belinostat Phase II clinical trials Ovarian cancer Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials T-cell lymphoma Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials Multiple myeloma Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials Acute myelogenous leukemia Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials Mesothelioma Cancer drugs TopoTarget AS
Belinostat Phase I clinical trials Hematological malignancies Cancer drugs TopoTarget AS
Belinostat Phase I/II clinical trials Hepatocellular cancer Cancer drugs TopoTarget AS
Belinostat Phase I clinical trials Solid tumors Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials Myelodysplastic syndrome Cancer drugs TopoTarget AS

Developer/partner
developer
Belinostat Phase I/II clinical trials Colorectal cancer Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials Bladder cancer Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials B-cell lymphoma Cancer drugs TopoTarget AS
Belinostat Phase II clinical trials Cancer Cancer drugs TopoTarget AS
Belinostat Oral Phase I clinical trials Solid tumors Cancer drugs TopoTarget AS
Bexidem Phase II clinical trials Bladder cancer Cancer drugs IDM Pharma Inc.
BEZ235 Phase I clinical trials Breast cancer Cancer drugs Novartis
BEZ235 Phase I clinical trials Glioma Cancer drugs Novartis
BEZ235 Phase I clinical trials Prostate cancer Cancer drugs Novartis
BiovaxID Phase III clinical trials Follicular non-Hodgkin’s Cancer drugs Biovest International Inc.
lymphoma
BN 2629 Phase I clinical trials Cancer Cancer drugs Ipsen Inc.
BNC105 Phase I clinical trials Cancer Cancer drugs Bionomics Ltd.
Bonefos Phase III clinical trials Bone metastases Cancer drugs Bayer HealthCare
Bosutinib Phase II clinical trials Breast cancer Cancer drugs Wyeth Pharmaceuticals
Bosutinib Phase III clinical trials Chronic myelogenous Cancer drugs Wyeth Pharmaceuticals
leukemia
Breast Cancer Vaccine Phase II clinical trials Breast cancer Cancer drugs Generex Biotechnology Corp.
Brostallicin Phase I/II clinical trials Solid tumors Cancer drugs Cell Therapeutics Inc.
BSI-201 Phase I clinical trials Solid tumors Cancer drugs BiPar Sciences Inc.
BSI-201 Phase II clinical trials Breast cancer Cancer drugs BiPar Sciences Inc.
BSI-201 Phase II clinical trials Uterine cancer Cancer drugs BiPar Sciences Inc.
BSI-201 Phase II clinical trials Ovarian cancer Cancer drugs BiPar Sciences Inc.
BSI-201 Phase II clinical trials Gioblastoma multiforme Cancer drugs BiPar Sciences Inc.
BZL101 Phase I/II clinical trials Breast cancer Cancer drugs BioNovo Inc.
CAL-101 Phase I clinical trials Hematologic cancer Cancer drugs Calistoga
CALAA01 Phase I clinical trials Solid tumors Cancer drugs Calando
Carfilzomib Phase II clinical trials Multiple myeloma Cancer drugs Proteolix Inc.
Carfilzomib Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Proteolix Inc.
Carfilzomib Phase II clinical trials Solid tumors Cancer drugs Proteolix Inc.
CAT-8015 Phase I clinical trials Hematological malignancies Cancer drugs AstraZeneca
Pharmaceuticals LP
Cavatak Phase I clinical trials Melanoma Cancer drugs Viralytics Ltd.
Cavatak Phase I clinical trials Prostate cancer Cancer drugs Viralytics Ltd.
Cavatak Phase I clinical trials Breast cancer Cancer drugs Viralytics Ltd.
CB3304 Phase I clinical trials Hematological malignancies Cancer drugs Cougar Biotechnology Inc.
CB3304 Phase I clinical trials Multiple myeloma Cancer drugs Cougar Biotechnology Inc.
CB7630 Phase III clinical trials Prostate cancer Cancer drugs Cougar Biotechnology Inc.
CBP501 Phase I clinical trials Lung cancer Cancer drugs CanBas Co.,
Takeda Pharmaceuticals
North America Inc.
CBP501 Phase I clinical trials Mesothelioma Cancer drugs CanBas Co.,
North America Inc.
CC-4047 Phase II clinical trials Myelofibrosis Cancer drugs Celgene Corp.
CC-4047 Phase II clinical trials Multiple myeloma Cancer drugs Celgene Corp.
10
Developer/partner
developer
CC-4047 Phase II clinical trials Solid tumors Cancer drugs Celgene Corp.
CD20 Antibody Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Eli Lilly and Co.
CDP-791 Phase II clinical trials Non-small cell lung cancer Cancer drugs UCB Pharma Inc.
CDX-110 Phase II/III clinical trials Glioblastoma multiforme Cancer drugs Pfizer Inc.
CDX-110 Phase II clinical trials Prostate cancer Cancer drugs Pfizer Inc.
CDX-110 Phase II clinical trials Ovarian cancer Cancer drugs Pfizer Inc.
CDX-1307 Phase I clinical trials Colorectal cancer Cancer drugs Celldex Therapeutics Inc.
CDX-1307 Phase I clinical trials Pancreatic cancer Cancer drugs Celldex Therapeutics Inc.
CDX-1307 Phase I clinical trials Bladder cancer Cancer drugs Celldex Therapeutics Inc.
CDX-1307 Phase I clinical trials Breast cancer Cancer drugs Celldex Therapeutics Inc.
CEP-11981 Phase I clinical trials Solid tumors Cancer drugs Cephalon Inc.
CEP-18770 Phase I clinical trials Multiple myeloma Cancer drugs Cephalon Inc.
CF102 Phase I clinical trials Liver cancer Cancer drugs Can-Fite BioPharma Ltd.
CG0070 Phase I clinical trials Bladder cancer Cancer drugs Cell Genesys Inc., Novartis
CG201 Phase I clinical trials Cancer Cancer drugs CG Therapeutics (CGT)
Chemophase Phase I/II clinical trials Bladder cancer Cancer drugs Halozyme Therapeutics Inc.
CHR-2797 Phase II clinical trials Non-small cell lung cancer Cancer drugs Chroma Therapeutics Ltd.
Cilengitide Phase III clinical trials Glioblastoma Cancer drugs EMD Serono Inc.
Cintredekin Besudotox Phase I clinical trials Glioma Cancer drugs NeoPharm Inc.
Cisplatin Lipid Complex Phase I/II clinical trials Osteosarcoma Cancer drugs Transave Inc.
Cisplatin Lipid Complex Phase I/II clinical trials Lung cancer Cancer drugs Transave Inc.
Cisplatin Lipid Complex Phase I/II clinical trials Bronchioloalveolar carcinoma Cancer drugs Transave Inc.
Clofarabine Phase I/II clinical trials Myelodysplastic syndrome Cancer drugs Genzyme Oncology Inc.
Clolar Phase III clinical trials Acute myelogenous leukemia Cancer drugs Genzyme Oncology Inc.
Clomet Phase I clinical trials Solid tumors Cancer drugs Antisoma Plc.
Cloretazine Phase III clinical trials Acute myelogenous leukemia Cancer drugs Vion Pharmaceuticals Inc.
Cloretazine Phase I/II clinical trials Brain tumor Cancer drugs Vion Pharmaceuticals Inc.
Cloretazine Phase II clinical trials Small cell lung cancer Cancer drugs Vion Pharmaceuticals Inc.
Cloretazine Phase I clinical trials Advanced malignancies Cancer drugs Vion Pharmaceuticals Inc.
CMC-544 Phase III clinical trials Non-Hodgkin’s lymphoma Cancer drugs UCB Pharma Inc.,
Wyeth Pharmaceuticals
Collidem Phase I clinical trials Colorectal cancer Cancer drugs IDM Pharma Inc.
Cordycepin Phase I/II clinical trials Acute lymphoblastic Cancer drugs OncoVista Inc.
leukemia
Cotara Phase II clinical trials Glioblastoma multiforme Cancer drugs Peregrine
CP-675206 Phase II clinical trials Metastatic melanoma Cancer drugs Pfizer Inc.
CP-675206 Phase II clinical trials Lung cancer Cancer drugs Pfizer Inc.
CP-675206 Phase II clinical trials Gastrointestinal cancer Cancer drugs Pfizer Inc.
CP-675206 Phase II clinical trials Genitourinary cancer Cancer drugs Pfizer Inc.
CP-675206 Phase II clinical trials Colorectal cancer Cancer drugs Pfizer Inc.
CP-675206 Phase II clinical trials Breast cancer Cancer drugs Pfizer Inc.
CP-675206 Phase II clinical trials Renal cell carcinoma Cancer drugs Pfizer Inc.
CP-675206 Phase II clinical trials Pancreatic cancer Cancer drugs Pfizer Inc.
CP-751871 Phase III clinical trials Non-small cell lung cancer Cancer drugs Pfizer Inc.
CP-751871 Phase II clinical trials Gastrointestinal cancer Cancer drugs Pfizer Inc.
CP-751871 Phase II clinical trials Genitourinary cancer Cancer drugs Pfizer Inc.
CP-751871 Phase II clinical trials Breast cancer Cancer drugs Pfizer Inc.
11
Developer/partner
developer
CP-751871 Phase III clinical trials Non-small cell lung cancer Cancer drugs Pfizer Inc.
CP-751871 Phase II clinical trials Ewing’s sarcoma Cancer drugs Pfizer Inc.
CP-870893 Phase I clinical trials Cancer Cancer drugs Pfizer Inc.
CPI-613 Phase I/II clinical trials Cancer Cancer drugs Cornerstone
CPI-613 Phase I/II clinical trials Pancreatic cancer Cancer drugs Cornerstone
CPX-1 Phase II clinical trials Colorectal cancer Cancer drugs Celator Pharmaceuticals Inc.
CPX-351 Phase I clinical trials Acute myeloid leukemia Cancer drugs Celator Pharmaceuticals Inc.
CR011-vcMMAE Phase II clinical trials Metastatic melanoma Cancer drugs CuraGen Corp.
CR011-vcMMAE Phase II clinical trials Breast cancer Cancer drugs CuraGen Corp.
CRx-026 Phase I/II clinical trials Solid tumors Cancer drugs CombinatoRx Inc.
CS-1008 Phase II clinical trials Cancer Cancer drugs Daiichi Sankyo Inc.
CS-7017 Phase I clinical trials Cancer Cancer drugs Daiichi Sankyo Inc.
CUDC-101 Phase I clinical trials Cancer Cancer drugs Curis Inc.
Curaxin CBLC102 Phase II clinical trials Hormone-refractory Cancer drugs Cleveland BioLabs Inc.
prostate cancer
CVX-045 Phase I clinical trials Cancer Cancer drugs Pfizer Inc.
CVX-060 Phase I clinical trials Solid tumors Cancer drugs Pfizer Inc.
CX-3543 Phase II clinical trials Chronic lymphocytic Cancer drugs Cylene Pharmaceuticals Inc.
leukemia
CX-3543 Phase I clinical trials Solid tumors Cancer drugs Cylene Pharmaceuticals Inc.
CYC116 Phase I clinical trials Solid tumors Cancer drugs Cyclacel
CYT-6091 Phase I clinical trials Cancer Cancer drugs CytImmune Sciences Inc.
CYT997 Phase II clinical trials Multiple myeloma Cancer drugs Cytopia Ltd.
CYT997 Phase I/II clinical trials Glioblastoma multiforme Cancer drugs Cytopia Ltd.
Dacogen Phase III clinical trials Acute myeloid leukemia Cancer drugs MGI Pharma Inc.
DAST inhibitor Phase I clinical trials Solid tumors Cancer drugs Bayer HealthCare
Davanat Phase II clinical trials Colorectal cancer Cancer drugs Pro-Pharmaceuticals Inc.
Davanat Phase II clinical trials Biliary cancer Cancer drugs Pro-Pharmaceuticals Inc.
Davanat Phase I clinical trials Breast cancer Cancer drugs Pro-Pharmaceuticals Inc.
DB-67 Phase I clinical trials Solid tumors Cancer drugs Arno Therapeutics Inc.
DCVax-Brain Phase II clinical trials Glioblastoma multiforme Cancer drugs Northwest Biotherapeutics Inc.
DCVax-L Phase I/II clinical trials Ovarian cancer Cancer drugs Northwest Biotherapeutics Inc.
DCVax-LB Phase I clinical trials Non-small cell lung cancer Cancer drugs Northwest Biotherapeutics Inc.
DCVax-Prostate Phase III clinical trials Prostate cancer Cancer drugs Northwest Biotherapeutics Inc.
Deforolimus Phase III clinical trials Soft tissue and bone sarcomas Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
Deforolimus Phase II clinical trials Prostate cancer Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
Deforolimus Phase II clinical trials Endometrial cancer Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
Deforolimus Phase II clinical trials Breast cancer Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
Deforolimus Phase I clinical trials Non-small cell lung cancer Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
Deforolimus Oral Phase II clinical trials Breast cancer Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
Deforolimus Oral Phase II clinical trials Endometrial cancer Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
12
Developer/partner
developer
Deforolimus Oral Phase II clinical trials Prostate cancer Cancer drugs Ariad Pharmaceuticals Inc.,
Merck & Co.
Deforolimus Oral Phase III clinical trials Soft-tissue and bone Cancer drugs Ariad Pharmaceuticals Inc.,
sarcomas Merck & Co.
Degarelix Awaiting approval Prostate cancer Cancer drugs Ferring Pharmaceuticals Inc.
Denosumab Phase III clinical trials Bone metastases Cancer drugs Amgen Inc.
Denosumab Phase III clinical trials Prostate cancer Cancer drugs Amgen Inc.
Denosumab Phase II clinical trials Multiple myeloma Cancer drugs Amgen Inc.
Denosumab Phase III clinical trials Cancer-related bone Cancer drugs Amgen Inc.
damage
Denosumab Phase III clinical trials Breast cancer Cancer drugs Amgen Inc.
DI17E6 Phase I clinical trials Solid tumors Cancer drugs EMD Serono Inc.
Dimericine Awaiting approval Skin cancer Cancer drugs AGI Dermatics
Dimericine Phase III clinical trials Xeroderma pigmentosum Cancer drugs AGI Dermatics
Doxil Awaiting approval Breast cancer Cancer drugs Ortho Biotech Products LP
Doxorubicin Transdrug Phase III clinical trials Hepatocellular carcinoma Cancer drugs BioAlliance Pharma
E7080 Phase I clinical trials Cancer Cancer drugs Eisai Inc.
E7389 Phase III clinical trials Breast cancer Cancer drugs Eisai Inc.
E7389 Phase II clinical trials Non-small cell lung cancer Cancer drugs Eisai Inc.
E7389 Phase II clinical trials Prostate cancer Cancer drugs Eisai Inc.
E7389 Phase II clinical trials Sarcoma Cancer drugs Eisai Inc.
E7820 Phase II clinical trials Colon cancer Cancer drugs Eisai Inc.
EC145 Phase II clinical trials Ovarian cancer Cancer drugs Endocyte Inc.
EC145 Phase II clinical trials Endometrial cancer Cancer drugs Endocyte Inc.
EC145 Phase II clinical trials Non-small cell lung cancer Cancer drugs Endocyte Inc.
Efaproxyn Awaiting approval Brain metastases Cancer drugs Allos Therapeutics Inc.
Eg 5 Inhibitor Phase I clinical trials Solid tumors Cancer drugs EMD Serono Inc.
Eg 5 Inhibitor Phase I clinical trials Hematological malignancies Cancer drugs EMD Serono Inc.
Eg5 Inhibitor Phase I clinical trials Cancer Cancer drugs Eli Lilly and Co.
EGEN-001 Phase I clinical trials Ovarian cancer Cancer drugs Expression Genetics Inc.
Elacyt Phase II clinical trials Malignant melanoma Cancer drugs Clavis Pharma ASA
Elacyt Phase II clinical trials Acute myeloid leukemia Cancer drugs Clavis Pharma ASA
Elacyt Phase II clinical trials Colorectal cancer Cancer drugs Clavis Pharma ASA
Elacyt Phase II clinical trials Ovarian cancer Cancer drugs Clavis Pharma ASA
Elesclomol Phase III clinical trials Metastatic melanoma Cancer drugs Synta Pharmaceuticals Corp.,
GlaxoSmithKline Inc.
Elotuzumab Phase I clinical trials Multiple myeloma Cancer drugs PDL BioPharma Inc.,
Bristol-Myers Squibb Co.
Elsamitrucin Phase I clinical trials Solid tumors Cancer drugs Spectrum
EM-1421 Phase I/II clinical trials Solid tumors Cancer drugs Erimos Pharmaceuticals LLC
EM-1421 Phase I/II clinical trials Brain tumor Cancer drugs Erimos Pharmaceuticals LLC
EM-1421 Phase II clinical trials Cervical intraepithelial Cancer drugs Erimos Pharmaceuticals LLC
neoplasia
EMD 273063 Phase II clinical trials Melanoma Cancer drugs EMD Serono Inc.
EMD 273063 Phase II clinical trials Neuroblastoma Cancer drugs EMD Serono Inc.
Eniluracil Phase I clinical trials Solid tumors Cancer drugs Adherex Technologies Inc.
Eniluracil Phase I/II clinical trials Liver cancer Cancer drugs Adherex Technologies Inc.
13
Developer/partner
developer
ENMD-1198 Phase I clinical trials Cancer Cancer drugs EntreMed Inc.
ENMD-1198 Phase I clinical trials Leukemia Cancer drugs EntreMed Inc.
ENMD-1198 Phase I clinical trials Solid tumors Cancer drugs EntreMed Inc.
ENMD-2076 Phase I clinical trials Cancer Cancer drugs EntreMed Inc.
Enzastaurin Phase III clinical trials Diffuse large B-cell lymphoma Cancer drugs Eli Lilly and Co.
Enzastaurin Phase II clinical trials Non-small cell lung cancer Cancer drugs Eli Lilly and Co.
Enzastaurin Phase II clinical trials Ovarian cancer Cancer drugs Eli Lilly and Co.
Enzastaurin Phase II clinical trials Prostate cancer Cancer drugs Eli Lilly and Co.
Enzastaurin Phase II clinical trials Colorectal cancer Cancer drugs Eli Lilly and Co.
Enzastaurin Phase II clinical trials Chronic lymphocytic Cancer drugs Eli Lilly and Co.
leukemia
Enzastaurin Phase II clinical trials Follicular lymphoma Cancer drugs Eli Lilly and Co.
Enzastaurin Phase II clinical trials Breast cancer Cancer drugs Eli Lilly and Co.
EOquin Phase III clinical trials Bladder cancer Cancer drugs Spectrum
EPC2407 Phase I clinical trials Solid tumors Cancer drugs EpiCept Corp.
EPC2407 Phase I clinical trials Lymphoma Cancer drugs EpiCept Corp.
EPO906 Phase III clinical trials Ovarian cancer Cancer drugs Novartis
Epratuzumab Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Immunomedics Inc.
Epratuzumab Phase II clinical trials Acute lymphoblastic Cancer drugs Immunomedics Inc.
leukemia
Erbitux Phase III clinical trials Non-small cell lung cancer Cancer drugs ImClone Systems Inc.,
Erbitux Awaiting approval Colorectal cancer Cancer drugs ImClone Systems Inc.,
Erbitux Awaiting approval Head and neck cancer Cancer drugs ImClone Systems Inc.,
Erbitux Phase III clinical trials Esophageal cancer Cancer drugs ImClone Systems Inc.,
Erbitux Phase III clinical trials Gastric cancer Cancer drugs ImClone Systems Inc.,
Erwinase Phase III clinical trials Acute lymphoblastic Cancer drugs EUSA Pharma
leukemia
Faslodex Phase III clinical trials Breast cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
Femara Phase III clinical trials Breast cancer Cancer drugs Novartis
Fenretinide Phase I clinical trials Soft tissue sarcoma Cancer drugs Cancer Research
Technology Ltd.
Ferritarg P Phase I/II clinical trials Hodgkin’s disease Cancer drugs MAT Biopharma
Forodesine Phase II clinical trials Chronic lymphocytic Cancer drugs BioCryst Pharmaceuticals Inc.
leukemia
FP-1039 Phase I clinical trials Solid tumors Cancer drugs Five Prime Therapeutics Inc.
Fusilev Awaiting approval Colorectal cancer Cancer drugs Spectrum
G4460 Phase I clinical trials Chronic myeloid leukemia Cancer drugs Genta Inc.
G4460 Phase I clinical trials Hematologic cancer Cancer drugs Genta Inc.
GA101 Phase I/II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Genentech Inc.,
Biogen Idec Inc.
GA101 Phase I/II clinical trials Chronic lymphocytic Cancer drugs Genentech Inc.,
leukemia Biogen Idec Inc.
Galiximab Phase III clinical trials Non-Hodgkin’s B cell Cancer drugs Biogen Idec Inc.
lymphoma
14
Developer/partner
developer
Galiximab Phase III clinical trials Follicular non-Hodgkin’s Cancer drugs Biogen Idec Inc.
lymphoma
GC1008 Phase I clinical trials Renal cell cancer Cancer drugs Genzyme Oncology Inc.
GC1008 Phase I clinical trials Melanoma Cancer drugs Genzyme Oncology Inc.
Gemzar Phase III clinical trials Breast cancer Cancer drugs Eli Lilly and Co.
Genasense Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Genta Inc.
Genasense Awaiting approval Chronic lymphocytic Cancer drugs Genta Inc.
leukemia
Genasense Phase III clinical trials Melanoma Cancer drugs Genta Inc.
GI-4000 Phase II clinical trials Pancreatic cancer Cancer drugs GlobeImmune Inc.
GI-4000 Phase II clinical trials Non-small cell lung cancer Cancer drugs GlobeImmune Inc.
Gleevec Phase III clinical trials Chronic myeloid leukemia Cancer drugs Novartis
Gleevec Awaiting approval Gastrointestinal stromal tumors Cancer drugs Novartis
Glufosfamide Phase III clinical trials Pancreatic cancer Cancer drugs Threshold
GMX1777 Phase I clinical trials Solid tumors Cancer drugs Gemin X Biotechnologies Inc.
GMX1777 Phase I clinical trials Lymphoma Cancer drugs Gemin X Biotechnologies Inc.
Graspa Phase II clinical trials Acute lymphoblastic Cancer drugs ERYtech Pharma US
leukemia
GRN163L Phase I/II clinical trials Chronic lymphocytic Cancer drugs Geron Corp.
leukemia
GRN163L Phase I clinical trials Multiple myeloma Cancer drugs Geron Corp.
GRN163L Phase I clinical trials Solid tumors Cancer drugs Geron Corp.
GRN163L Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Geron Corp.
GRN163L Phase I/II clinical trials Breast cancer Cancer drugs Geron Corp.
GRNVAC1 Phase II clinical trials Acute myelogenous leukemia Cancer drugs Geron Corp.
GS 9219 Phase I clinical trials Hematologic cancer Cancer drugs Gilead Sciences Inc.
GV1001 Phase III clinical trials Pancreatic cancer Cancer drugs Pharmexa-Epimmune Inc.
GVAX Leukemia Vaccine Phase II clinical trials Acute myelogenous leukemia Cancer drugs Cell Genesys Inc.
GVAX Leukemia Vaccine Phase II clinical trials Chronic myelogenous Cancer drugs Cell Genesys Inc.
leukemia
GVAX Leukemia Vaccine Phase II clinical trials Myelodysplastic syndrome Cancer drugs Cell Genesys Inc.
GVAX Pancreatic Cancer Phase II clinical trials Pancreatic cancer Cancer drugs Cell Genesys Inc.
Vaccine
GVAX Prostate Cancer Phase I clinical trials Prostate cancer Cancer drugs Takeda Pharmaceuticals
Vaccine North America Inc.
GX15-070 Phase II clinical trials Hodgkin’s disease Cancer drugs Gemin X Pharmaceuticals Inc.
GX15-070 Phase II clinical trials Myelofibrosis Cancer drugs Gemin X Pharmaceuticals Inc.
GX15-070 Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Gemin X Pharmaceuticals Inc.
GX15-070 Phase II clinical trials Follicular lymphoma Cancer drugs Gemin X Pharmaceuticals Inc.
HCD122 Phase I/II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Novartis Pharmaceuticals
Corp., Xoma Ltd.
HCD122 Phase I clinical trials Multiple myeloma Cancer drugs Novartis Pharmaceuticals
Corp., Xoma Ltd.
HDAC inhibitor Phase I clinical trials Solid tumors Cancer drugs Pharmacyclics Inc.
HDAC inhibitor Phase I clinical trials Hematological malignancies Cancer drugs Pharmacyclics Inc.
Herceptin Phase III clinical trials Breast cancer Cancer drugs Genentech Inc.
Herceptin and Pertuzumab Phase III clinical trials Breast cancer Cancer drugs Genentech Inc.
Plus Docetaxel
Chemotherapy
15
Developer/partner
developer
Hexvix Fluorescence Phase III clinical trials Bladder cancer Cancer drugs PhotoCure ASA
Cystoscopy
HF10 Phase I clinical trials Head and neck cancer Cancer drugs M’s Science Co. (MSC)
HGS-ETR1 Phase I clinical trials Solid tumors Cancer drugs Human Genome Sciences
Inc., GlaxoSmithKline Inc.
HGS-ETR1 Phase II clinical trials Multiple myeloma Cancer drugs Human Genome Sciences
HGS-ETR1 Phase II clinical trials Non-small cell lung cancer Cancer drugs Human Genome Sciences
HGS-ETR1 Phase II clinical trials Hepatocellular cancer Cancer drugs Human Genome Sciences
HGS-ETR2 Phase I clinical trials Cancer Cancer drugs Human Genome
Sciences Inc.
HGS1029 Phase I clinical trials Solid tumors Cancer drugs Human Genome
Sciences Inc.
HIF-1 Alpha Antagonist Phase I clinical trials Solid tumors Cancer drugs Enzon Pharmaceuticals Inc.,
Santaris Pharma
HIF-1 Alpha Antagonist Phase I clinical trials Lymphoma Cancer drugs Enzon Pharmaceuticals Inc.,
Santaris Pharma
HMPL-002 Phase I/II clinical trials Head and neck cancer Cancer drugs Hutchison China
Meditech Ltd.
HMPL-002 Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Hutchison China
Meditech Ltd.
Hsp90 inhibitor Phase II clinical trials Solid tumors Cancer drugs Biogen Idec Inc.
HspE7 Phase I clinical trials Cervical intraepithelial Cancer drugs Nventa
neoplasia Biopharmaceuticals Corp.
HuMax-CD38 Phase I/II clinical trials Multiple myeloma Cancer drugs Genmab Inc.
HuMax-EGFr Phase III clinical trials Head and neck cancer Cancer drugs Genmab Inc.
HuMax-EGFr Phase III clinical trials Head and neck cancer Cancer drugs Genmab Inc.
huN901-DM1 Phase II clinical trials Small cell lung cancer Cancer drugs ImmunoGen Inc.
huN901-DM1 Phase I clinical trials Solid tumors Cancer drugs ImmunoGen Inc.
huN901-DM1 Phase I clinical trials Multiple myeloma Cancer drugs ImmunoGen Inc.
HyCAMP Phase II clinical trials Colorectal cancer Cancer drugs Alchemia Inc.
Hycamtin Phase III clinical trials Ovarian cancer Cancer drugs GlaxoSmithKline Inc.
Hycamtin Oral Awaiting approval Small cell lung cancer Cancer drugs GlaxoSmithKline Inc.
IAP Antagonist Phase I clinical trials Cancer Cancer drugs Genentech Inc.
Iboctadekin/Rituximab Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs GlaxoSmithKline Inc.
Combination
IDM-2101 Phase II clinical trials Non-small cell lung cancer Cancer drugs IDM Pharma Inc.
IGFBP-3 Phase I/II clinical trials Cancer Cancer drugs Insmed Inc.
IL-21 Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs ZymoGenetics Inc.
IL-21 Phase II clinical trials Renal cell cancer Cancer drugs ZymoGenetics Inc.
IL-21 Phase II clinical trials Metastatic melanoma Cancer drugs ZymoGenetics Inc.
IL-21 Phase I clinical trials Colorectal cancer Cancer drugs ZymoGenetics Inc.
IMC-1121B Phase II clinical trials Solid tumors Cancer drugs ImClone Systems Inc.
IMC-1121B Phase II clinical trials Renal cell cancer Cancer drugs ImClone Systems Inc.
IMC-1121B Phase II clinical trials Malignant melanoma Cancer drugs ImClone Systems Inc.
IMC-1121B Phase II clinical trials Hepatocellular carcinoma Cancer drugs ImClone Systems Inc.
IMC-1121B Phase III clinical trials Metastatic breast cancer Cancer drugs ImClone Systems Inc.
IMC-1121B Phase II clinical trials Prostate cancer Cancer drugs ImClone Systems Inc.
IMC-1121B Phase II clinical trials Ovarian cancer Cancer drugs ImClone Systems Inc.
IMC-18F1 Phase I clinical trials Colorectal cancer Cancer drugs ImClone Systems Inc.
16
Developer/partner
developer
IMC-18F1 Phase I clinical trials Breast cancer Cancer drugs ImClone Systems Inc.
IMC-3G3 Phase I clinical trials Prostate cancer Cancer drugs ImClone Systems Inc.
IMC-3G3 Phase I clinical trials Breast cancer Cancer drugs ImClone Systems Inc.
IMC-3G3 Phase I clinical trials Ovarian cancer Cancer drugs ImClone Systems Inc.
IMC-A12 Phase II clinical trials Pancreatic cancer Cancer drugs ImClone Systems Inc.
IMC-A12 Phase II clinical trials Prostate cancer Cancer drugs ImClone Systems Inc.
IMC-A12 Phase II clinical trials Colorectal cancer Cancer drugs ImClone Systems Inc.
IMC-A12 Phase I/II clinical trials Solid malignancies Cancer drugs ImClone Systems Inc.
IMC-A12 Phase II clinical trials Head and neck cancer Cancer drugs ImClone Systems Inc.
IMC-A12 Phase II clinical trials Liver cancer Cancer drugs ImClone Systems Inc.
IMC-A12 Phase I clinical trials Advanced malignancies Cancer drugs ImClone Systems Inc.
IMC-A12 Phase I clinical trials Lymphoma Cancer drugs ImClone Systems Inc.
IMC-A12 Phase II clinical trials Soft tissue sarcoma Cancer drugs ImClone Systems Inc.
IMC-A12 Phase II clinical trials Breast cancer Cancer drugs ImClone Systems Inc.
IMGN242 Phase I clinical trials Colorectal cancer Cancer drugs ImmunoGen Inc.
IMGN242 Phase I clinical trials Pancreatic cancer Cancer drugs ImmunoGen Inc.
IMGN242 Phase II clinical trials Gastric cancer Cancer drugs ImmunoGen Inc.
IMGN242 Phase I clinical trials Non-small cell lung cancer Cancer drugs ImmunoGen Inc.
IMGN388 Phase I clinical trials Cancer Cancer drugs ImmunoGen Inc.
IMMU-101 Phase I clinical trials Pancreatic cancer Cancer drugs Immunomedics Inc.
ImmuFact IMP321 Phase I clinical trials Pancreatic cancer Cancer drugs Immutep SA
IMOxine Phase II clinical trials Renal cell cancer Cancer drugs Idera Pharmaceuticals Inc.
IMOxine Phase I/II clinical trials Solid tumors Cancer drugs Idera Pharmaceuticals Inc.
IMOxine Phase I clinical trials Non-small cell lung cancer Cancer drugs Idera Pharmaceuticals Inc.
Imprime PGG Phase I/II clinical trials Cancer Cancer drugs Biothera
Imprime PGG Phase II clinical trials Colorectal cancer Cancer drugs Biothera
IMT-1012 Phase I clinical trials Ovarian cancer Cancer drugs Immunotope Inc.
Immunotherapeutic
Vaccine
IMT-1012 Phase I clinical trials Breast cancer Cancer drugs Immunotope Inc.
Immunotherapeutic
Vaccine
IMUC Vaccine Phase I clinical trials Brain tumor Cancer drugs ImmunoCellular
Therapeutics Ltd.
INCB18424 Phase II clinical trials Myelofibrosis Cancer drugs Incyte Corp.
INCB18424 Phase I/II clinical trials Post-polycythemia and post- Cancer drugs Incyte Corp.
essential thrombocythemia
INCB7839 Phase II clinical trials Solid tumors Cancer drugs Incyte Corp.
INCB7839 Phase II clinical trials Breast cancer Cancer drugs Incyte Corp.
INCB7839 Phase II clinical trials Breast cancer Cancer drugs Incyte Corp.
Indibulin Phase I clinical trials Cancer Cancer drugs Ziopharm Oncology Inc.
Indibulin Phase I/II clinical trials Solid tumors Cancer drugs Ziopharm Oncology Inc.
INGN 225 Phase II clinical trials Small cell lung cancer Cancer drugs Introgen Therapeutics Inc.
INGN 225 Phase II clinical trials Breast cancer Cancer drugs Introgen Therapeutics Inc.
INGN 241 Phase III clinical trials Solid tumors Cancer drugs Introgen Therapeutics Inc.
INGN 241 Phase II clinical trials Metastatic melanoma Cancer drugs Introgen Therapeutics Inc.
INGN 401 Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Introgen Therapeutics Inc.
Injectable Collagenase Phase I clinical trials Lipoma Cancer drugs BioSpecifics
Technologies Corp.
INNO-206 Phase II clinical trials Small cell lung cancer Cancer drugs Innovive Pharmaceuticals Inc.
17
Developer/partner
developer
INNO-305 Phase I clinical trials Acute myelogenous leukemia Cancer drugs Innovive Pharmaceuticals Inc.
INNO-305 Phase I clinical trials Myelodysplastic syndrome Cancer drugs Innovive Pharmaceuticals Inc.
INNO-305 Phase I clinical trials Non-small cell lung cancer Cancer drugs Innovive Pharmaceuticals Inc.
INNO-305 Phase I clinical trials Mesothelioma Cancer drugs Innovive Pharmaceuticals Inc.
INNO-406 Phase I clinical trials Chronic myelogenous Cancer drugs Innovive Pharmaceuticals Inc.
leukemia
Interleukin-7 Phase I/II clinical trials Cancer Cancer drugs Cytheris Inc.
IPH 2101 Phase I clinical trials Multiple myeloma Cancer drugs Innate Pharma SA
IPI-493 Phase I clinical trials Solid tumors Cancer drugs MedImmune Inc.
Ipilimumab Phase II clinical trials Hormone-refractory prostate Cancer drugs Medarex Inc.,
cancer Bristol-Myers Squibb Co.
Ipilimumab Phase II clinical trials Breast cancer Cancer drugs Medarex Inc.,
Ipilimumab Phase III clinical trials Metastatic melanoma Cancer drugs Medarex Inc.,
Ipilimumab Phase II clinical trials Lung cancer Cancer drugs Medarex Inc.,
Ipilimumab Phase I/II clinical trials Prostate cancer Cancer drugs Medarex Inc.,
Ipilimumab Phase II clinical trials Bladder cancer Cancer drugs Medarex Inc.,
Ipilimumab Phase II clinical trials Pancreatic cancer Cancer drugs Medarex Inc.,
Ipilimumab Phase I clinical trials Leukemia Cancer drugs Medarex Inc.,
Ipilimumab Phase I clinical trials Lymphoma Cancer drugs Medarex Inc.,
Ipilimumab Phase II clinical trials Small cell lung cancer Cancer drugs Medarex Inc.,
Ipilimumab Phase II clinical trials Non-small cell lung cancer Cancer drugs Medarex Inc.,
Irofulven Phase II clinical trials Hormone-refractory prostate Cancer drugs MGI Pharma Inc.
cancer
IRX-2 Phase II clinical trials Head and neck cancer Cancer drugs IRX Therapeutics Inc.
ISO-Vorin Awaiting approval Osteogenic sarcoma Cancer drugs Spectrum
ISO-Vorin Phase III clinical trials Colorectal cancer Cancer drugs Spectrum
Ispinesib Phase II clinical trials Ovarian cancer Cancer drugs Cytokinetics Inc.
Ispinesib Phase II clinical trials Colorectal cancer Cancer drugs Cytokinetics Inc.
Ispinesib Phase II clinical trials Hormone-refractory prostate Cancer drugs Cytokinetics Inc.
cancer
Ispinesib Phase II clinical trials Renal cell cancer Cancer drugs Cytokinetics Inc.
Ispinesib Phase II clinical trials Hepatocellular cancer Cancer drugs Cytokinetics Inc.
Ispinesib Phase II clinical trials Breast cancer Cancer drugs Cytokinetics Inc.
Ispinesib Phase II clinical trials Head and neck cancer Cancer drugs Cytokinetics Inc.
Ispinesib Phase II clinical trials Melanoma Cancer drugs Cytokinetics Inc.
Ispinesib Phase I clinical trials Solid tumors Cancer drugs Cytokinetics Inc.
IT-101 Phase I clinical trials Solid tumors Cancer drugs Calando
IT-101 Phase II clinical trials Ovarian cancer Cancer drugs Calando
IT-101 Phase II clinical trials Lymphoma Cancer drugs Calando
18
Developer/partner
developer
JNJ-26481585 Phase I clinical trials Solid and hematological Cancer drugs Ortho Biotech Oncology
malignancies Research & Development
JNJ-26854165 Phase I clinical trials Non-small cell lung cancer Cancer drugs Ortho Biotech Oncology
Research & Development
JNJ-26854165 Phase I clinical trials Prostate cancer Cancer drugs Ortho Biotech Oncology
Research & Development
JNJ-38877605 Phase I clinical trials Multiple metastasized Cancer drugs Ortho Biotech Oncology
malignancies Research & Development
Junovan Awaiting approval Osteosarcoma Cancer drugs IDM Pharma Inc.
JX-594 Phase II clinical trials Liver cancer Cancer drugs Jennerex Biotherapeutics
JX-594 Phase II clinical trials Head and neck cancer Cancer drugs Jennerex Biotherapeutics
JX-594 Phase I clinical trials Solid tumors Cancer drugs Jennerex Biotherapeutics
JX-929 Phase I clinical trials Lung cancer Cancer drugs Jennerex Biotherapeutics
JX-929 Phase I clinical trials Colon cancer Cancer drugs Jennerex Biotherapeutics
JX-929 Phase I clinical trials Ovarian cancer Cancer drugs Jennerex Biotherapeutics
Karenitecin Phase II clinical trials Non-small cell lung cancer Cancer drugs BioNumerik
Karenitecin Phase II clinical trials Melanoma Cancer drugs BioNumerik
Karenitecin Phase II clinical trials Brain tumor Cancer drugs BioNumerik
Karenitecin Phase III clinical trials Ovarian cancer Cancer drugs BioNumerik
KOS-1584 Phase I clinical trials Solid tumors Cancer drugs Bristol-Myers Squibb Co.
KOS-1584 Phase II clinical trials Non-small cell lung cancer Cancer drugs Bristol-Myers Squibb Co.
KRN 330 Phase I clinical trials Solid tumors Cancer drugs Kyowa Hakko Kirin Co.
KRX-0401 Phase II clinical trials Head and neck cancer Cancer drugs Keryx Biopharmaceuticals Inc.
KRX-0401 Phase II clinical trials Prostate cancer Cancer drugs Keryx Biopharmaceuticals Inc.
KRX-0401 Phase II clinical trials Breast cancer Cancer drugs Keryx Biopharmaceuticals Inc.
KRX-0401 Phase II clinical trials Multiple myeloma Cancer drugs Keryx Biopharmaceuticals Inc.
KRX-0401 Phase II clinical trials Renal cell carcinoma Cancer drugs Keryx Biopharmaceuticals Inc.
KRX-0401 Phase II clinical trials Sarcoma Cancer drugs Keryx Biopharmaceuticals Inc.
KRX-0401 Phase II clinical trials Waldenstrom Cancer drugs Keryx Biopharmaceuticals Inc.
macroglobulinemia
KRX-601 Phase II clinical trials Cancer Cancer drugs Keryx Biopharmaceuticals Inc.
KW-2449 Phase I clinical trials Cancer Cancer drugs Kyowa Pharmaceutical Inc.
KW-2871 Phase I/II clinical trials Malignant melanoma Cancer drugs Life Science
KX2-391 Phase I clinical trials Cancer Cancer drugs Kinex Pharmaceuticals LLC
L19-Interleukin 2 Phase I clinical trials Pancreatic cancer Cancer drugs Bayer HealthCare
L19-Interleukin 2 Phase II clinical trials Renal cell cancer Cancer drugs Bayer HealthCare
L19-Interleukin 2 Phase I clinical trials Melanoma Cancer drugs Bayer HealthCare
L19-SIP Phase I clinical trials Solid tumors Cancer drugs Bayer HealthCare
L19-TNFalpha Phase I clinical trials Cancer Cancer drugs Bayer HealthCare
Larotaxel Phase III clinical trials Breast cancer Cancer drugs Sanofi-Aventis
Larotaxel Phase III clinical trials Pancreatic cancer Cancer drugs Sanofi-Aventis
LBH589 Phase I clinical trials Hematological and Cancer drugs Novartis
solid tumors Pharmaceuticals Corp.
19
Developer/partner
developer
LBH589 Phase II clinical trials Cutaneous T-cell lymphoma Cancer drugs Novartis
LBQ707 Phase II clinical trials Solid tumors Cancer drugs Novartis
LBY135 Phase I clinical trials Solid tumors Cancer drugs Novartis
LE-DT Phase I clinical trials Solid tumors Cancer drugs NeoPharm Inc.
LE-SN38 Phase II clinical trials Colorectal cancer Cancer drugs NeoPharm Inc.
Lenocta Phase II clinical trials Solid tumors Cancer drugs VioQuest
Lenocta Phase II clinical trials Melanoma Cancer drugs VioQuest
Lenocta Phase II clinical trials Renal cell carcinoma Cancer drugs VioQuest
LEP-ETU Phase II clinical trials Breast cancer Cancer drugs NeoPharm Inc.
Lestaurtinib Phase III clinical trials Acute myeloid leukemia Cancer drugs Cephalon Inc.
Lestaurtinib Phase II clinical trials Myeloproliferative disorder Cancer drugs Cephalon Inc.
Levoleucovorin Awaiting approval Osteosarcoma Cancer drugs Spectrum
Litx Phase III clinical trials Colorectal cancer Cancer drugs Light Sciences Oncology Inc.
LOR-2040 Phase I/II clinical trials Colorectal cancer Cancer drugs Lorus Therapeutics Inc.
LOR-2040 Phase II clinical trials Renal cell cancer Cancer drugs Lorus Therapeutics Inc.
LOR-2040 Phase II clinical trials Acute myeloid leukemia Cancer drugs Lorus Therapeutics Inc.
LOR-2040 Phase I/II clinical trials Breast cancer Cancer drugs Lorus Therapeutics Inc.
LOR-2040 Phase I clinical trials Myelodysplastic syndrome Cancer drugs Lorus Therapeutics Inc.
Lovaxin C Phase I clinical trials Cervical cancer Cancer drugs Advaxis Inc.
Lovaxin C Phase I clinical trials Head and neck cancer Cancer drugs Advaxis Inc.
LP-261 Phase I clinical trials Cancer Cancer drugs Locus Pharmaceuticals Inc.
Lucanix Phase III clinical trials Non-small cell lung cancer Cancer drugs NovaRx Corp.
Lucanthone Phase I clinical trials Brain cancer Cancer drugs Spectrum
Lumiliximab Phase II clinical trials Chronic lymphocytic Cancer drugs Biogen Idec Inc.
leukemia
LX1032 Phase I clinical trials Carcinoid syndrome Cancer drugs Lexicon Pharmaceuticals Inc.
LY2181308 Phase II clinical trials Liver cancer Cancer drugs Eli Lilly and Co.
LY2181308 Phase II clinical trials Prostate cancer Cancer drugs Eli Lilly and Co.
LY2181308 Phase II clinical trials Acute myelogenous leukemia Cancer drugs Eli Lilly and Co.
LY2181308 Phase II clinical trials Ovarian cancer Cancer drugs Eli Lilly and Co.
LY2181308 Phase II clinical trials Non-small cell lung cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Head and neck cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Breast cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Prostate cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Lung cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Bladder cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Colon cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Thyroid cancer Cancer drugs Eli Lilly and Co.
LY2275796 Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Eli Lilly and Co.
M-Vax Phase III clinical trials Metastatic melanoma Cancer drugs Avax Technologies Inc.
MAGE-A3 Phase III clinical trials Non-small cell lung cancer Cancer drugs GlaxoSmithKline Inc.
MAGE-A3 Phase II clinical trials Melanoma Cancer drugs GlaxoSmithKline Inc.
Marqibo Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Hana Biosciences Inc.
20
Developer/partner
developer
Marqibo Phase II clinical trials Acute lymphoblastic Cancer drugs Hana Biosciences Inc.
leukemia
Marqibo Phase II clinical trials Malignant melanoma Cancer drugs Hana Biosciences Inc.
Marqibo Phase II clinical trials Metastatic melanoma Cancer drugs Hana Biosciences Inc.
Matuzumab Phase II clinical trials Gastric cancer Cancer drugs EMD Serono Inc.
Matuzumab Phase II clinical trials Colorectal cancer Cancer drugs EMD Serono Inc.
Matuzumab Phase II clinical trials Non-small cell lung cancer Cancer drugs EMD Serono Inc.
MB07133 Phase I/II clinical trials Liver cancer Cancer drugs Metabasis Therapeutics Inc.
MDV3100 Phase I/II clinical trials Hormone-refractory prostate Cancer drugs Medivation Inc.
cancer
MDX-060 Phase II clinical trials Anaplastic large cell Cancer drugs Medarex Inc.
lymphoma
MDX-060 Phase II clinical trials Hodgkin’s disease Cancer drugs Medarex Inc.
MDX-1106 Phase I clinical trials Cancer Cancer drugs Medarex Inc.,
Ono Pharma USA Inc.
MDX-1342 Phase I clinical trials Chronic lymphocytic Cancer drugs Medarex Inc.
leukemia
MDX-1401 Phase I clinical trials Lymphoma Cancer drugs Medarex Inc.
MDX-1401 Phase I clinical trials Hodgkin’s disease Cancer drugs Medarex Inc.
MDX-1411 Phase I clinical trials Renal cell cancer Cancer drugs Medarex Inc.
MEDI-538 Phase II clinical trials Leukemia Cancer drugs MedImmune Inc.
MEDI-538 Phase II clinical trials Lymphoma Cancer drugs MedImmune Inc.
MedPulser Bleomycin Phase I/II clinical trials Breast cancer Cancer drugs Inovio Biomedical Corp.
MEK Inhibitor Phase I clinical trials Cancer Cancer drugs Genentech Inc.
Melanoma Vaccine Phase I clinical trials Melanoma Cancer drugs Sanofi Pasteur
MER-101 Phase II clinical trials Cancer Cancer drugs Merrion Pharmaceuticals LLC
MER-104 Phase I clinical trials Prostate cancer Cancer drugs Merrion Pharmaceuticals LLC
Mesupron Phase II clinical trials Breast cancer Cancer drugs Wilex AG
MetMab Phase I clinical trials Cancer Cancer drugs Genentech Inc.
MGCD0103 Phase II clinical trials Hodgkin’s lymphoma Cancer drugs Celgene Corp.,
MethylGene Inc.
MGCD0103 Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Celgene Corp.,
MethylGene Inc.
MGCD0103 Phase II clinical trials Myelodysplastic syndrome Cancer drugs Celgene Corp.,
MethylGene Inc.
MGCD0103 Phase I clinical trials Solid tumors Cancer drugs Celgene Corp.,
MethylGene Inc.
MGCD0103 Phase II clinical trials Pancreatic cancer Cancer drugs Celgene Corp.,
MethylGene Inc.
MGCD0103 Phase II clinical trials Chronic lymphocytic Cancer drugs Celgene Corp.,
leukemia MethylGene Inc.
MGCD0103 Phase II clinical trials Acute myeloid leukemia Cancer drugs Celgene Corp.,
MethylGene Inc.
MGN1703 Phase I clinical trials Cancer Cancer drugs Mologen Holding AG
Milatuzumab Phase I/II clinical trials Multiple myeloma Cancer drugs Immunomedics Inc.
Milatuzumab Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Immunomedics Inc.
Milatuzumab Phase I clinical trials Chronic lymphocytic Cancer drugs Immunomedics Inc.
leukemia
MK-0646 Phase II clinical trials Colon cancer Cancer drugs Merck & Co.
MK-0646 Phase II clinical trials Non-small cell lung cancer Cancer drugs Merck & Co.
MK-0752 Phase I clinical trials Cancer Cancer drugs Merck & Co.
MK-0822 Phase II clinical trials Cancer Cancer drugs Merck & Co.
21
Developer/partner
developer
MKC-1 Phase II clinical trials Non-small cell lung cancer Cancer drugs EntreMed Inc.
MKC-1 Phase II clinical trials Breast cancer Cancer drugs EntreMed Inc.
MKC-1 Phase I clinical trials Leukemia Cancer drugs EntreMed Inc.
MKC-1 Phase II clinical trials Pancreatic cancer Cancer drugs EntreMed Inc.
MKC1106-PP Phase I clinical trials Solid malignancies Cancer drugs MannKind Corp.
MLN0518 Phase II clinical trials Acute myeloid leukemia Cancer drugs Millennium: The Takeda
Oncology Company
MLN0518 Phase II clinical trials Glioblastoma Cancer drugs Millennium: The Takeda
Oncology Company
MLN4924 Phase I clinical trials Advanced malignancies Cancer drugs Millennium: The Takeda
Oncology Company
Oncology Company
Oncology Company
MM-121 Phase I clinical trials Cancer Cancer drugs Merrimack
MN-029 Phase I clinical trials Solid tumors Cancer drugs MediciNova Inc.
MN-201 Phase I clinical trials Cancer Cancer drugs Marillion Pharmaceuticals Inc.
Monoclonal Antibody Phase I clinical trials Melanoma Cancer drugs Pain Therapeutics Inc.
MORAb-003 Phase II clinical trials Ovarian cancer Cancer drugs Morphotek Inc.
MORAb-009 Phase II clinical trials Pancreatic cancer Cancer drugs Morphotek Inc.
MORAb-009 Phase I clinical trials Lung cancer Cancer drugs Morphotek Inc.
Motesanib Diphosphate Phase II clinical trials Thyroid cancer Cancer drugs Amgen Inc.,
North America Inc.
Motesanib Diphosphate Phase II clinical trials Breast cancer Cancer drugs Amgen Inc.,
North America Inc.
Motesanib Diphosphate Phase III clinical trials Non-small cell lung cancer Cancer drugs Amgen Inc.,
North America Inc.
MP470 Phase I clinical trials Solid tumors Cancer drugs SuperGen Inc.
MP470 Phase I clinical trials Glioblastoma multiforme Cancer drugs SuperGen Inc.
MPC-2130 Phase I clinical trials Cancer Cancer drugs Myriad Pharmaceuticals Inc.
MSX-122 Phase I clinical trials Cancer Cancer drugs Metastatix
MT103 Phase I/II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Micromet AG,
MedImmune Inc.
MT110 Phase I clinical trials Solid tumors Cancer drugs Micromet Inc.
MT110 Phase I clinical trials Lung cancer Cancer drugs Micromet Inc.
MT110 Phase I clinical trials Gastric cancer Cancer drugs Micromet Inc.
Multikine Phase III clinical trials Head and neck cancer Cancer drugs Cel-Sci Corp.
MVA-BN HER-2 Phase I/II clinical trials Breast cancer Cancer drugs Bavarian Nordic AS
MVA-BN PRO Phase I/II clinical trials Prostate cancer Cancer drugs Bavarian Nordic AS
MVA-BN/Her-2 Phase I/II clinical trials Breast cancer Cancer drugs BN ImmunoTherapeutics Inc.
Neratinib Phase II clinical trials Breast cancer Cancer drugs Wyeth Pharmaceuticals
Neuradiab Phase III clinical trials Glioblastoma multiforme Cancer drugs Bradmer Pharmaceuticals Inc.
NeuVax Phase II clinical trials Breast cancer Cancer drugs Apthera Inc.
22
Developer/partner
developer
Nexavar Phase III clinical trials Melanoma Cancer drugs Onyx Pharmaceuticals
Inc., Bayer HealthCare
Nexavar Phase II clinical trials Breast cancer Cancer drugs Onyx Pharmaceuticals
Nexavar Phase II clinical trials Non-small cell lung cancer Cancer drugs Onyx Pharmaceuticals
Nexavar Phase II clinical trials Thyroid cancer Cancer drugs Onyx Pharmaceuticals
Nexavar Phase II clinical trials Gastrointestinal cancer Cancer drugs Onyx Pharmaceuticals
Nexavar Phase II clinical trials Adenocarcinoma Cancer drugs Onyx Pharmaceuticals
Nexavar Phase II clinical trials Ovarian cancer Cancer drugs Onyx Pharmaceuticals
Nexavar Phase III clinical trials Hepatocellular carcinoma Cancer drugs Onyx Pharmaceuticals
NHS-IL2-LT Phase I clinical trials Solid tumors Cancer drugs EMD Serono Inc.
Nimotuzumab Phase II clinical trials Pediatric brain cancer Cancer drugs YM BioSciences Inc.
NKTR-102 Phase II clinical trials Ovarian cancer Cancer drugs Nektar Therapeutics
NKTR-102 Phase II clinical trials Colorectal cancer Cancer drugs Nektar Therapeutics
NKTR-102 Phase II clinical trials Breast cancer Cancer drugs Nektar Therapeutics
NOV-002 Phase III clinical trials Non-small cell lung cancer Cancer drugs Novelos Therapeutics Inc.
NOV-002 Phase II clinical trials Ovarian cancer Cancer drugs Novelos Therapeutics Inc.
NOV-002 Phase II clinical trials Breast cancer Cancer drugs Novelos Therapeutics Inc.
Novel SERD Phase I clinical trials Breast cancer Cancer drugs Bayer HealthCare
NPI-0052 Phase I clinical trials Solid tumors Cancer drugs Nereus Pharmaceuticals Inc.
NPI-0052 Phase I clinical trials Lymphoma Cancer drugs Nereus Pharmaceuticals Inc.
NPI-0052 Phase I clinical trials Multiple myeloma Cancer drugs Nereus Pharmaceuticals Inc.
NPI-2358 Phase I clinical trials Solid tumors Cancer drugs Nereus Pharmaceuticals Inc.
NPI-2358 Phase I clinical trials Non-small cell lung cancer Cancer drugs Nereus Pharmaceuticals Inc.
Nplate Phase II clinical trials Myelodysplastic syndrome Cancer drugs Amgen Inc.
NRX4204 Phase I clinical trials Non-small cell lung cancer Cancer drugs NuRx Pharmaceuticals Inc.
NRX4204 Phase I clinical trials Breast cancer Cancer drugs NuRx Pharmaceuticals Inc.
Nuvigil Phase II clinical trials Cancer fatigue Cancer drugs Cephalon Inc.
NV1020 Phase I/II clinical trials Liver metastasis Cancer drugs MediGene AG
O-Vax Phase I/II clinical trials Ovarian cancer Cancer drugs Avax Technologies Inc.
Ofatumumab Phase III clinical trials Chronic lymphocytic Cancer drugs Genmab Inc.,
leukemia GlaxoSmithKline Inc.
Ofatumumab Phase III clinical trials Non-Hodgkin’s lymphoma Cancer drugs Genmab Inc.,
Ofatumumab Phase II clinical trials Relapsing remitting multiple Cancer drugs Genmab Inc.,
sclerosis GlaxoSmithKline Inc.
OGX-011 Phase II clinical trials Non-small cell lung cancer Cancer drugs OncoGenex
OGX-011 Phase II clinical trials Prostate cancer Cancer drugs OncoGenex
23
Developer/partner
developer
OGX-427 Phase I clinical trials Breast cancer Cancer drugs OncoGenex
OGX-427 Phase I clinical trials Ovarian cancer Cancer drugs OncoGenex
OGX-427 Phase I clinical trials Bladder cancer Cancer drugs OncoGenex
OGX-427 Phase I clinical trials Prostate cancer Cancer drugs OncoGenex
OGX-427 Phase I clinical trials Lung cancer Cancer drugs OncoGenex
Omacetaxine Phase II/III clinical trials Chronic myeloid leukemia Cancer drugs ChemGenex
mepesuccinate Therapeutics Inc.
Omacetaxine Phase II clinical trials Myelodysplastic syndrome Cancer drugs ChemGenex
mepesuccinate Therapeutics Inc.
ON 01910.Na Phase I clinical trials Cancer Cancer drugs Onconova Therapeutics Inc.
Onalta Phase II clinical trials Carcinoid tumors Cancer drugs Molecular Insight
Onalta Phase II clinical trials Neuroendocrine tumors Cancer drugs Molecular Insight
Oncaspar Phase I clinical trials Lymphoma Cancer drugs Enzon Pharmaceuticals Inc.
Oncaspar Phase I clinical trials Solid tumors Cancer drugs Enzon Pharmaceuticals Inc.
OncoGel Phase II clinical trials Esophageal cancer Cancer drugs Protherics Inc.
OncoGel Phase I/II clinical trials Brain cancer Cancer drugs Protherics Inc.
OncoMet Phase I clinical trials Cancer Cancer drugs ItherX Pharmaceuticals Inc.
Onconase Awaiting approval Mesothelioma Cancer drugs Alfacell Corp.
Onconase Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Alfacell Corp.
Oncophage Phase III clinical trials Metastatic melanoma Cancer drugs Antigenics Inc.
Oncophage Phase I/II clinical trials Glioma Cancer drugs Antigenics Inc.
Oncophage Phase III clinical trials Kidney cancer Cancer drugs Antigenics Inc.
Oncophage Phase II clinical trials Non-small cell lung cancer Cancer drugs Antigenics Inc.
OncoVEX Phase II clinical trials Metastatic melanoma Cancer drugs BioVex Inc.
OncoVEX Phase I/II clinical trials Head and neck cancer Cancer drugs BioVex Inc.
OncoVEX Phase I/II clinical trials Pancreatic cancer Cancer drugs BioVex Inc.
Oral Fludarabine Awaiting approval Chronic lymphocytic Cancer drugs Antisoma Plc.
leukemia
Oral Picoplatin Phase I clinical trials Solid tumors Cancer drugs Poniard Pharmaceuticals Inc.
Orathecin Phase II clinical trials Pancreatic cancer Cancer drugs SuperGen Inc.
OSI-027 Phase I clinical trials Cancer Cancer drugs OSI Pharmaceuticals Inc.
OVI-237 Phase II clinical trials Breast cancer Cancer drugs OncoVista Inc.
Oxi4503 Phase I clinical trials Solid tumors Cancer drugs Oxigene Inc.
Ozarelix Phase II clinical trials Prostate cancer Cancer drugs Spectrum
Ozarelix Phase II clinical trials Benign prostate hypertrophy Cancer drugs Spectrum
Ozarelix Phase II clinical trials Breast cancer Cancer drugs Spectrum
P2045 Phase I clinical trials Lung cancer Cancer drugs Antisoma Plc.
P2045 Phase I clinical trials Lung cancer Cancer drugs Antisoma Plc.
Palifosfamide Phase I clinical trials Cancer Cancer drugs Ziopharm Oncology Inc.
24
Developer/partner
developer
Palifosfamide Phase II clinical trials Soft-tissue and bone Cancer drugs Ziopharm Oncology Inc.
sarcomas
PAM4 Phase I clinical trials Pancreatic cancer Cancer drugs Immunomedics Inc.
Panzem Phase I clinical trials Breast cancer Cancer drugs EntreMed Inc.
Panzem Phase II clinical trials Multiple myeloma Cancer drugs EntreMed Inc.
Panzem Phase II clinical trials Prostate cancer Cancer drugs EntreMed Inc.
Panzem Phase II clinical trials Renal cell carcinoma Cancer drugs EntreMed Inc.
Panzem NCD Phase II clinical trials Glioblastoma multiforme Cancer drugs EntreMed Inc.
Panzem NCD Phase I clinical trials Breast cancer Cancer drugs EntreMed Inc.
Panzem NCD Phase II clinical trials Carcinoid tumors Cancer drugs EntreMed Inc.
Panzem NCD Phase II clinical trials Ovarian cancer Cancer drugs EntreMed Inc.
Panzem NCD Phase II clinical trials Hormone-refractory Cancer drugs EntreMed Inc.
prostate cancer
PapViRx Phase II clinical trials Cervical cancer Cancer drugs Virionics Corp.
PCK3145 Phase I/II clinical trials Prostate cancer Cancer drugs Ambrilia BioPharma Inc.
PD-325901 Phase I clinical trials Cancer Cancer drugs Pfizer Inc.
PD-332991 Phase I clinical trials Cancer Cancer drugs Pfizer Inc.
PDL192 Phase I clinical trials Solid tumors Cancer drugs PDL BioPharma Inc., Biogen
Idec Inc.
PDX Phase II clinical trials T-cell lymphoma Cancer drugs Allos Therapeutics Inc.
PDX Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Allos Therapeutics Inc.
PDX Phase I clinical trials Cutaneous T-cell lymphoma Cancer drugs Allos Therapeutics Inc.
PDX Phase II clinical trials Transitorial cell bladder cancer Cancer drugs Allos Therapeutics Inc.
PEG-SN38 Phase I clinical trials Solid tumors Cancer drugs Enzon Pharmaceuticals Inc.
PEG-SN38 Phase I clinical trials Lymphoma Cancer drugs Enzon Pharmaceuticals Inc.
PegIntron Awaiting approval Malignant melanoma Cancer drugs Schering-Plough Corp.
PEP005 Topical Phase II clinical trials Basal cell carcinoma Cancer drugs Peplin Ltd.
Pertuzumab Phase II clinical trials Ovarian cancer Cancer drugs Genentech Inc., Hoffmann-La
Roche Inc.
Pertuzumab Phase III clinical trials Breast cancer Cancer drugs Genentech Inc., Hoffmann-La
Roche Inc.
PF-2341066 Phase I clinical trials Cancer Cancer drugs Pfizer Inc.
PF-3512676 Phase II clinical trials Non-small cell lung cancer Cancer drugs Pfizer Inc.
PG-11047 Phase I clinical trials Solid tumors Cancer drugs Progen Pharmaceuticals Inc.
PG-11047 Phase I clinical trials Lymphoma Cancer drugs Progen Pharmaceuticals Inc.
PG-11047 Phase II clinical trials Hormone-refractory Cancer drugs Progen Pharmaceuticals Inc.
prostate cancer
PH20 Phase I/II clinical trials Cancer Cancer drugs Halozyme Therapeutics Inc.
Phenoxodiol Phase I/II clinical trials Ovarian cancer Cancer drugs Marshall Edwards Inc.
Phenylbutyrate Phase II clinical trials Glioblastoma multiforme Cancer drugs Access Pharmaceuticals Inc.
25
Developer/partner
developer
PI-88 Phase II clinical trials Melanoma Cancer drugs Progen Pharmaceutical Ltd.
PI-88 Phase III clinical trials Liver cancer Cancer drugs Progen Pharmaceutical Ltd.
PI-88 Phase II clinical trials Prostate cancer Cancer drugs Progen Pharmaceutical Ltd.
PI3 Kinase Inhibitor Phase I clinical trials Cancer Cancer drugs Genentech Inc.
Picoplatin Phase III clinical trials Small cell lung cancer Cancer drugs Poniard Pharmaceuticals Inc.
Picoplatin Phase II clinical trials Colorectal cancer Cancer drugs Poniard Pharmaceuticals Inc.
Picoplatin Phase II clinical trials Hormone-refractory prostate Cancer drugs Poniard Pharmaceuticals Inc.
cancer
Pixantrone Phase III clinical trials Relapsed indolent non- Cancer drugs Cell Therapeutics Inc.
Hodgkin’s lymphoma
Pixantrone Phase I clinical trials Acute myelogenous leukemia Cancer drugs Cell Therapeutics Inc.
Pixantrone Phase III clinical trials Relapsed aggressive Cancer drugs Cell Therapeutics Inc.
non-Hodgkin’s lymphoma
Pixantrone Phase III clinical trials Relapsed diffuse large B cell Cancer drugs Cell Therapeutics Inc.
non-Hodgkin’s lymphoma
PKC412 Phase III clinical trials Acute myeloid leukemia Cancer drugs Novartis
PLX4032/R7204 Phase I clinical trials Melanoma Cancer drugs Plexxikon Inc.,
PNT2258 Phase I clinical trials Cancer Cancer drugs ProNAi Therapeutics Inc.
Polyphenon E Phase II clinical trials Chronic lymphocytic Cancer drugs Polyphenon Pharma
leukemia
PRLX 93936 Phase I clinical trials Solid tumors Cancer drugs Prolexys Pharmaceuticals Inc.
ProLindac Phase II clinical trials Solid tumors Cancer drugs Access Pharmaceuticals Inc.
ProLindac Phase II clinical trials Head and neck cancer Cancer drugs Access Pharmaceuticals Inc.
Prostate Cancer Vaccine Phase I clinical trials Prostate cancer Vaccines Generex Biotechnology Corp.
Prostvac Phase II clinical trials Prostate cancer Cancer drugs Bavarian Nordic AS
Provecta Phase II clinical trials Metastatic melanoma Cancer drugs Provectus
Provecta Phase II clinical trials Breast cancer Cancer drugs Provectus
Provenge Awaiting approval Prostate cancer Cancer drugs Dendreon Corp.
Proxinium Phase III clinical trials Head and neck cancer Cancer drugs Viventia Biotech Inc.
PRX302 Phase II clinical trials Prostate cancer Cancer drugs Protox Therapeutics Inc.
PRX321 Phase I clinical trials Renal cell carcinoma Cancer drugs Protox Therapeutics Inc.
PRX321 Phase I clinical trials Non-small cell lung cancer Cancer drugs Protox Therapeutics Inc.
PRX321 Phase II clinical trials Brain cancer Cancer drugs Protox Therapeutics Inc.
PSMA Antibody Phase I clinical trials Prostate cancer Cancer drugs Progenics
PTC299 Phase I/II clinical trials Breast cancer Cancer drugs PTC Therapeutics Inc.
PX-12 Phase I clinical trials Gastrointestinal cancer Cancer drugs Oncothyreon Inc.
PX-12 Phase II clinical trials Pancreatic cancer Cancer drugs Oncothyreon Inc.
PX-12 Phase I clinical trials Advanced cancer Cancer drugs Oncothyreon Inc.
PX-478 Phase I clinical trials Cancer Cancer drugs Oncothyreon Inc.
PX-866 Phase I clinical trials Cancer Cancer drugs Oncothyreon Inc.
R1507 Phase II clinical trials Ewing’s sarcoma Cancer drugs Hoffmann-La Roche Inc.,
Genmab Inc.
R1530 Phase I clinical trials Solid tumors Cancer drugs Hoffmann-La Roche Inc.
R3484 Phase II clinical trials Cervical neoplasia Cancer drugs Hoffmann-La Roche Inc.
26
Developer/partner
developer
R7112 Phase I clinical trials Cancer Cancer drugs Hoffmann-La Roche Inc.
R7159 Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Hoffmann-La Roche Inc.
R763/AS703569 Phase I clinical trials Solid tumors Cancer drugs EMD Serono Inc.
R763/AS703569 Phase I clinical trials Hematological malignancies Cancer drugs EMD Serono Inc.
R788 Phase II clinical trials B-cell non-Hodgkin’s Cancer drugs Rigel Pharmaceuticals Inc.
lymphoma
RAF265 Phase I clinical trials Melanoma Cancer drugs Novartis
RAV12 Phase I/II clinical trials Adenocarcinoma Cancer drugs Raven Biotechnologies Inc.
RAV12 Phase II clinical trials Pancreatic cancer Cancer drugs Raven Biotechnologies Inc.
RDEA119 Phase I/II clinical trials Cancer Cancer drugs Ardea Biosciences Inc.
Recentin Phase II clinical trials Non-small cell lung cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
Recentin Phase III clinical trials Colorectal cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
Recentin Phase III clinical trials Glioblastoma Cancer drugs AstraZeneca
Pharmaceuticals LP
Redectane Phase III clinical trials Renal cell cancer Cancer drugs Wilex AG
Rencarex Phase III clinical trials Non-metastatic renal cell Cancer drugs Wilex AG
cancer
Rencarex Phase II clinical trials Metastatic renal cell cancer Cancer drugs Wilex AG
Rencarex Phase III clinical trials Renal cell cancer Cancer drugs Wilex AG
Reolysin Phase II clinical trials Solid tumors Cancer drugs Oncolytics Biotech Inc.
Reolysin Phase I/II clinical trials Glioma Cancer drugs Oncolytics Biotech Inc.
Reolysin Phase II clinical trials Sarcoma Cancer drugs Oncolytics Biotech Inc.
Reolysin Phase II clinical trials Metastatic melanoma Cancer drugs Oncolytics Biotech Inc.
Reolysin Phase I/II clinical trials Ovarian cancer Cancer drugs Oncolytics Biotech Inc.
Reolysin Phase II clinical trials Head and neck cancer Cancer drugs Oncolytics Biotech Inc.
Retaspimycin Phase I clinical trials Multiple myeloma Cancer drugs Infinity Pharmaceuticals Inc.,
MedImmune Inc.
Retaspimycin Phase III clinical trials Gastrointestinal stromal tumors Cancer drugs Infinity Pharmaceuticals Inc.,
MedImmune Inc.
Retaspimycin Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Infinity Pharmaceuticals Inc.,
MedImmune Inc.
Retaspimycin Phase II clinical trials Solid tumors Cancer drugs Infinity Pharmaceuticals Inc.,
MedImmune Inc.
Reviroc Phase III clinical trials Blood cancer Cancer drugs Kiadis Pharma BV
Revlimid Phase II clinical trials Solid tumors Cancer drugs Celgene Corp.
Revlimid Phase III clinical trials Myelodysplastic syndrome Cancer drugs Celgene Corp.
Revlimid Phase III clinical trials Non-Hodgkin’s lymphoma Cancer drugs Celgene Corp.
Revlimid Phase III clinical trials Chronic lymphocytic Cancer drugs Celgene Corp.
leukemia
Rexin-G Phase I/II clinical trials Pancreatic cancer Cancer drugs Epeius Biotechnologies Corp.
Rexin-G Phase I/II clinical trials Breast cancer Cancer drugs Epeius Biotechnologies Corp.
Rexin-G Phase I/II clinical trials Sarcoma Cancer drugs Epeius Biotechnologies Corp.
Rexin-G Phase II clinical trials Osteosarcoma Cancer drugs Epeius Biotechnologies Corp.
Rexin-G Phase I/II clinical trials Metastatic breast cancer Cancer drugs Epeius Biotechnologies Corp.
RH1 Phase I clinical trials Solid tumors Cancer drugs Allos Therapeutics Inc.
RH1 Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Allos Therapeutics Inc.
27
Developer/partner
developer
rhApo2L/Trail Phase I clinical trials Cancer Cancer drugs Amgen Inc., Genentech Inc.
rhApo2L/Trail Phase II clinical trials Non-small cell lung cancer Cancer drugs Amgen Inc., Genentech Inc.
rhApo2L/Trail Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Amgen Inc., Genentech Inc.
rhApo2L/Trail Phase II clinical trials Non-small cell lung cancer Cancer drugs Amgen Inc., Genentech Inc.
rhApo2L/Trail Phase I clinical trials Colorectal cancer Cancer drugs Amgen Inc., Genentech Inc.
Rituxan Phase III clinical trials Chronic lymphocytic Cancer drugs Biogen Idec Inc., Genentech
leukemia Inc., Hoffmann-La Roche Inc.
Rituxan Phase III clinical trials Follicular non-Hodgkin’s Cancer drugs Biogen Idec Inc., Genentech
lymphoma Inc., Hoffmann-La Roche Inc.
Romidepsin Phase II clinical trials Cutaneous T-cell lymphoma Cancer drugs Gloucester
Romidepsin Phase II clinical trials Multiple myeloma Cancer drugs Gloucester
Romidepsin Phase III clinical trials Peripheral T-cell lymphoma Cancer drugs Gloucester
Romidepsin Phase I clinical trials Solid tumors Cancer drugs Gloucester
RP101 Phase II clinical trials Pancreatic cancer Cancer drugs SciClone
RTA 402 Phase II clinical trials Metastatic melanoma Cancer drugs Reata Pharmaceuticals Inc.
RTA 402 Phase I/II clinical trials Pancreatic cancer Cancer drugs Reata Pharmaceuticals Inc.
RTA 744 Phase II clinical trials Brain cancer Cancer drugs Reata Pharmaceuticals Inc.
S-1 Phase III clinical trials Gastric cancer Cancer drugs Taiho Pharmaceutical Co.
S-1 Phase III clinical trials Colorectal cancer Cancer drugs Taiho Pharmaceutical Co.
S-1 Phase III clinical trials Pancreatic cancer Cancer drugs Taiho Pharmaceutical Co.
Sagopilone Phase II clinical trials Breast cancer Cancer drugs Bayer HealthCare
Sagopilone Phase II clinical trials Ovarian cancer Cancer drugs Bayer HealthCare
Sagopilone Phase II clinical trials Prostate cancer Cancer drugs Bayer HealthCare
Sagopilone Phase II clinical trials Lung cancer Cancer drugs Bayer HealthCare
Salirasib Phase I clinical trials Solid tumors Cancer drugs Concordia
Salirasib Phase I clinical trials Hematological malignancies Cancer drugs Concordia
Salirasib Phase II clinical trials Pancreatic cancer Cancer drugs Concordia
Salirasib Phase II clinical trials Lung cancer Cancer drugs Concordia
Sapacitabine Phase II clinical trials Myelodysplastic syndrome Cancer drugs Cyclacel
Sapacitabine Phase II clinical trials Myeloid leukemia Cancer drugs Cyclacel
Sapacitabine Phase II clinical trials Cutaneous T-cell lymphoma Cancer drugs Cyclacel
Sapacitabine Phase II clinical trials Acute myeloid leukemia Cancer drugs Cyclacel
SAR3419 Phase I clinical trials Non-Hodgkin’s lymphoma Cancer drugs Sanofi-Aventis
Sarasar Phase II clinical trials Breast cancer Cancer drugs Schering-Plough Corp.
Satraplatin Phase I clinical trials Non-small cell lung cancer Cancer drugs Spectrum Pharmaceuticals
Inc., GPC Biotech AG
Satraplatin Phase I clinical trials Solid tumors Cancer drugs Spectrum Pharmaceuticals
Inc., GPC Biotech AG
28
Developer/partner
developer
Satraplatin Phase II clinical trials Hormone-refractory prostate Cancer drugs Spectrum Pharmaceuticals
cancer Inc., GPC Biotech AG
SB-743921 Phase I/II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Cytokinetics Inc.
SB-743921 Phase I clinical trials Tumors Cancer drugs Cytokinetics Inc.
SB1518 Phase I clinical trials Myeloproliferative disorders Cancer drugs S BIO Pte Ltd.
Seliciclib Phase II clinical trials Non-small cell lung cancer Cancer drugs Cyclacel
Seliciclib Phase II clinical trials Nasopharyngeal cancer Cancer drugs Cyclacel
Seocalcitol Phase I clinical trials Prostate cancer Cancer drugs Cougar Biotechnology Inc.
SF1126 Phase I clinical trials Prostate cancer Cancer drugs Semafore
SF1126 Phase I clinical trials Solid tumors Cancer drugs Semafore
SF1126 Phase I clinical trials Multiple myeloma Cancer drugs Semafore
SG 2000 Phase I clinical trials Solid tumors Cancer drugs SpiroGen Ltd.
SGN-33 Phase II clinical trials Acute myeloid leukemia Cancer drugs Seattle Genetics Inc.
SGN-33 Phase I clinical trials Myelodysplastic syndrome Cancer drugs Seattle Genetics Inc.
SGN-35 Phase I clinical trials Hematological malignancies Cancer drugs Seattle Genetics Inc.
SGN-35 Phase I clinical trials Hodgkin’s disease Cancer drugs Seattle Genetics Inc.
SGN-70 Phase I clinical trials Hematological malignancies Cancer drugs Seattle Genetics Inc.
SGX523 Phase I clinical trials Solid tumors Cancer drugs SGX Pharmaceuticals Inc.
SL-401 Phase I clinical trials Hematologic cancer Cancer drugs Stemline Therapeutics Inc.
SNS-032 Phase I clinical trials Chronic lymphocytic Cancer drugs Sunesis Pharmaceuticals Inc.
leukemia
SNS-032 Phase I clinical trials Multiple myeloma Cancer drugs Sunesis Pharmaceuticals Inc.
SNS-314 Phase I clinical trials Solid tumors Cancer drugs Sunesis Pharmaceuticals Inc.
SNX-5422 Phase I clinical trials Solid tumors Cancer drugs Pfizer Inc.
SNX-5422 Phase I clinical trials Hematological malignancies Cancer drugs Pfizer Inc.
SOM230 Phase II clinical trials Refractory carcinoid tumors Cancer drugs Novartis
SP1049C Phase III clinical trials Gastrointestinal tract Cancer drugs Supratek Pharma Inc.
adenocarcinoma
Specifid Phase III clinical trials Follicular B-cell non-Hodgkin’s Cancer drugs Favrille Inc.
lymphoma
Specifid Phase III clinical trials B-cell non-Hodgkin’s Cancer drugs Favrille Inc.
lymphoma
SPI-1620 Phase I clinical trials Cancer Cancer drugs Spectrum
Sprycel Phase III clinical trials Chronic myeloid leukemia Cancer drugs Bristol-Myers Squibb Co.
Squalamine Phase II clinical trials Ovarian cancer Cancer drugs Genaera Corp.
Squalamine Phase II clinical trials Non-small cell lung cancer Cancer drugs Genaera Corp.
SSR244738 Phase I clinical trials Cancer Cancer drugs Sanofi-Aventis
SSR97225 Phase I clinical trials Cancer Cancer drugs Sanofi-Aventis
STA-9090 Phase I clinical trials Solid tumors Cancer drugs Synta Pharmaceuticals Corp.
StemEX Phase III clinical trials Hematological malignancies Cancer drugs Gamida Cell Ltd., Teva
Pharmaceuticals USA Inc.
Stimuvax Phase III clinical trials Non-small cell lung cancer Cancer drugs EMD Serono Inc.
STS Phase III clinical trials Hepatoblastoma Cancer drugs Adherex Technologies Inc.
SU-14813 Phase II clinical trials Breast cancer Cancer drugs Pfizer Inc.
Survivac Phase I clinical trials Solid tumors Cancer drugs EMD Serono Inc.
29
Developer/partner
developer
Sutent Phase III clinical trials Lung cancer Cancer drugs Pfizer Inc.
Sutent Phase II clinical trials Gastric cancer Cancer drugs Pfizer Inc.
Sutent Phase III clinical trials Breast cancer Cancer drugs Pfizer Inc.
Sutent Phase III clinical trials Colorectal cancer Cancer drugs Pfizer Inc.
Sutent Phase III clinical trials Prostate cancer Cancer drugs Pfizer Inc.
Sutent Phase III clinical trials Hepatocellular cancer Cancer drugs Pfizer Inc.
Systemic Hedgehog Phase II clinical trials Basal cell carcinoma Cancer drugs Genentech Inc.
Antagonist
Systemic Hedgehog Phase II clinical trials Colorectal cancer Cancer drugs Genentech Inc.
Antagonist
Systemic Hedgehog Phase II clinical trials Ovarian cancer Cancer drugs Genentech Inc.
Antagonist
Talactoferrin Phase II clinical trials Renal cell cancer Cancer drugs Agennix Inc.
Talactoferrin Phase II clinical trials Non-small cell lung cancer Cancer drugs Agennix Inc.
Talampanel Phase II clinical trials Glioblastoma Cancer drugs Teva Pharmaceuticals
USA Inc.
Tamibarotene Phase II clinical trials Acute promyelocytic Cancer drugs Innovive Pharmaceuticals Inc.
leukemia
Tanespimycin Phase III clinical trials Multiple myeloma Cancer drugs Bristol-Myers Squibb Co.
Tanespimycin Phase II clinical trials Breast cancer Cancer drugs Bristol-Myers Squibb Co.
Tanespimycin Phase II clinical trials Metastatic melanoma Cancer drugs Bristol-Myers Squibb Co.
Tarceva Phase III clinical trials Non-small cell lung cancer Cancer drugs Genentech Inc., OSI
Tarceva Phase III clinical trials Ovarian cancer Cancer drugs Genentech Inc., OSI
Tarceva Phase III clinical trials Colorectal cancer Cancer drugs Genentech Inc., OSI
Tasigna Phase III clinical trials Gastrointestinal stromal tumors Cancer drugs Novartis
Tasigna Phase III clinical trials Chronic myeloid leukemia Cancer drugs Novartis
TASQ Phase II clinical trials Prostate cancer Cancer drugs Active Biotech AB
Tavocept Phase II clinical trials Non-small cell lung cancer Cancer drugs BioNumerik
Telcyta Phase II clinical trials Colorectal cancer Cancer drugs Telik Inc.
Telcyta Phase III clinical trials Non-small cell lung cancer Cancer drugs Telik Inc.
Telcyta Phase III clinical trials Ovarian cancer Cancer drugs Telik Inc.
Telcyta Phase III clinical trials Non-small cell lung cancer Cancer drugs Telik Inc.
Telintra Phase II clinical trials Myelodysplastic syndrome Cancer drugs Telik Inc.
Telintra Tablet Phase I/II clinical trials Myelodysplastic syndrome Cancer drugs Telik Inc.
Telintra Tablet Phase II clinical trials Chemotherapy-induced Cancer drugs Telik Inc.
neutropenia
Telomelysin Phase I clinical trials Solid tumors Cancer drugs Oncolys BioPharma Inc.
Temodar Phase II clinical trials Solid tumors Cancer drugs Schering-Plough Corp.
Temodar Phase II clinical trials Brain metastases Cancer drugs Schering-Plough Corp.
Temodar Phase III clinical trials Metastatic melanoma Cancer drugs Schering-Plough Corp.
Tesetaxel Phase II clinical trials Cancer Cancer drugs Genta Inc.
Tesmilifene Phase II clinical trials Hormone-refractory prostate Cancer drugs YM Biosciences Inc.
cancer
Teverelix LA Phase II clinical trials Prostate cancer Cancer drugs Ardana Plc.
TG 1042 Phase II clinical trials B-cell lymphoma Cancer drugs Transgene Inc.
TG-0054 Phase I clinical trials Cancer Cancer drugs TaiGen Biotechnology Co.
30
Developer/partner
developer
TG101348 Phase I/II clinical trials Myeloproliferative disorders Cancer drugs TargeGen Inc.
TGF Beta Inhibitor Phase I clinical trials Solid tumors Cancer drugs Eli Lilly and Co.
TH-302 Phase I clinical trials Cancer Cancer drugs Threshold
TH-302 Phase I/II clinical trials Soft tissue and bone sarcomas Cancer drugs Threshold
ThermoDox Phase III clinical trials Liver cancer Cancer drugs Celsion Corp.
ThermoDox Phase I clinical trials Breast cancer Cancer drugs Celsion Corp.
Thymectacin Phase I/II clinical trials Solid tumors Cancer drugs Kiadis Pharma BV
Thymoglobulin Phase II clinical trials Myelodysplastic syndrome Cancer drugs Genzyme Oncology Inc.
Tirapazamine Phase III clinical trials Solid tumors Cancer drugs SRI International
TK Therapy Phase I clinical trials Acute myeloid leukemia Cancer drugs MolMed S.p.A
TKI258 Phase I clinical trials Solid and liquid tumors Cancer drugs Novartis
TLN-4601 Phase II clinical trials Glioblastoma multiforme Cancer drugs Thallion Pharmaceuticals Inc.
TLR9 agonist Phase I clinical trials Colorectal cancer Cancer drugs Dynavax Technologies Corp.
TLR9 agonist Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Dynavax Technologies Corp.
TM601 Phase II clinical trials Malignant glioma Cancer drugs TransMolecular Inc.
TM601 Phase II clinical trials Metastatic melanoma Cancer drugs TransMolecular Inc.
TNFerade Phase III clinical trials Pancreatic cancer Cancer drugs GenVec Inc.
TNFerade Phase II clinical trials Esophageal cancer Cancer drugs GenVec Inc.
TNFerade Phase II clinical trials Rectal cancer Cancer drugs GenVec Inc.
TNFerade Phase I/II clinical trials Head and neck cancer Cancer drugs GenVec Inc.
TNFerade Phase II clinical trials Metastatic melanoma Cancer drugs GenVec Inc.
Tocosol Camptothecin Phase I clinical trials Solid tumors Cancer drugs OncoGenex
Torisel Phase III clinical trials Mantle cell lymphoma Cancer drugs Wyeth Pharmaceuticals
Torisel Phase III clinical trials Renal cell carcinoma Cancer drugs Wyeth Pharmaceuticals
Tovok Phase III clinical trials Lung cancer Cancer drugs Boehringer Ingelheim
Trastuzumab-DM1 Phase II clinical trials Breast cancer Cancer drugs Genentech Inc.,
TRC093 Phase I clinical trials Solid tumors Cancer drugs Tracon Pharmaceuticals Inc.
TRC102 Phase I clinical trials Cancer Cancer drugs Tracon Pharmaceuticals Inc.
TRC105 Phase I clinical trials Solid tumors Cancer drugs Tracon Pharmaceuticals Inc.
Trelstar 6-Month Phase III clinical trials Prostate cancer Cancer drugs Debiopharm SA
Triapine Phase II clinical trials Cancer Cancer drugs Vion Pharmaceuticals Inc.
Trisenox Phase III clinical trials Acute myeloid leukemia Cancer drugs Cephalon Inc.
TroVax Phase III clinical trials Renal cell cancer Cancer drugs Oxford Biomedica Plc.,
Sanofi-Aventis
TroVax Phase II clinical trials Prostate cancer Cancer drugs Oxford Biomedica Plc.,
Sanofi-Aventis
TroVax Phase II clinical trials Breast cancer Cancer drugs Oxford Biomedica Plc.,
Sanofi-Aventis
TRU-016 Phase I/II clinical trials B-cell malignancies Cancer drugs Trubion Pharmaceuticals Inc.
TRU-016 Phase I/II clinical trials Chronic lymphocytic Cancer drugs Trubion Pharmaceuticals Inc.
leukemia
Tucotuzumab Celmoleukin Phase II clinical trials Small cell lung cancer Cancer drugs EMD Serono Inc.
Tucotuzumab Celmoleukin Phase II clinical trials Ovarian cancer Cancer drugs EMD Serono Inc.
Tykerb Phase III clinical trials Head and neck cancer Cancer drugs GlaxoSmithKline Inc.
Tykerb Phase III clinical trials Breast cancer Cancer drugs GlaxoSmithKline Inc.
31
Developer/partner
developer
Tysabri Phase I/II clinical trials Multiple myeloma Cancer drugs Elan Pharmaceuticals Inc.,
Biogen Idec Inc.
U3-1287 Phase I clinical trials Cancer Cancer drugs Daiichi Sankyo Inc.
UNBS 5162 Phase I clinical trials Solid tumors Cancer drugs Drais Pharmaceuticals Inc.
UNBS 5162 Phase I clinical trials Lymphoma Cancer drugs Drais Pharmaceuticals Inc.
Urocidin Phase III clinical trials Bladder cancer Cancer drugs Bioniche Life Sciences Inc.
Uvidem Phase II clinical trials Melanoma Cancer drugs IDM Pharma Inc.
V930 Phase I clinical trials Cancer Cancer drugs Merck & Co.
Valstar Awaiting approval Bladder cancer Cancer drugs Indevus Pharmaceuticals Inc.
Vectibix Phase III clinical trials Colorectal cancer Cancer drugs Amgen Inc.
Vectibix Phase III clinical trials Head and neck cancer Cancer drugs Amgen Inc.
VEGF Trap-Cancer Phase III clinical trials Non-small cell lung cancer Cancer drugs Regeneron Pharmaceuticals
Inc., Sanofi-Aventis
VEGF Trap-Cancer Phase III clinical trials Ovarian cancer Cancer drugs Regeneron Pharmaceuticals
VEGF Trap-Cancer Phase III clinical trials Colorectal cancer Cancer drugs Regeneron Pharmaceuticals
VEGF Trap-Cancer Phase III clinical trials Prostate cancer Cancer drugs Regeneron Pharmaceuticals
VEGF Trap-Cancer Phase III clinical trials Pancreatic cancer Cancer drugs Regeneron Pharmaceuticals
Velcade Phase III clinical trials Follicular lymphoma Cancer drugs Millennium: The Takeda
Oncology Company,
Johnson & Johnson
Pharmaceutical Research &
Development
Velcade Phase II clinical trials Non-small cell lung cancer Cancer drugs Millennium: The Takeda
Oncology Company,
Johnson & Johnson
Development
Velcade Phase I/II clinical trials Lung cancer Cancer drugs Millennium: The Takeda
Oncology Company,
Johnson & Johnson
Development
Velcade Phase I/II clinical trials Breast cancer Cancer drugs Millennium: The Takeda
Oncology Company,
Johnson & Johnson
Development
Velcade Phase I/II clinical trials Prostate cancer Cancer drugs Millennium: The Takeda
Oncology Company,
Johnson & Johnson
Development
Velcade Phase I/II clinical trials Ovarian cancer Cancer drugs Millennium: The Takeda
Oncology Company,
Johnson & Johnson
Development
Veltuzumab Phase I/II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Immunomedics Inc.
Veltuzumab Phase I/II clinical trials Chronic lymphocytic Cancer drugs Immunomedics Inc.
leukemia
Vicinium Phase II clinical trials Bladder cancer Cancer drugs Viventia Biotech Inc.
Vidaza Phase II clinical trials Solid tumors Cancer drugs Celgene Corp.
Vidaza Phase II clinical trials Acute myelogenous leukemia Cancer drugs Celgene Corp.
Vidaza Oral Phase I clinical trials Acute myelogenous leukemia Cancer drugs Celgene Corp.
Vidaza Oral Phase I clinical trials Myelodysplastic syndrome Cancer drugs Celgene Corp.
32
Developer/partner
developer
Vinflunine Phase III clinical trials Cancer Cancer drugs Laboratoires Pierre Fabre SA
Virulizin Phase III clinical trials Pancreatic cancer Cancer drugs Zoticon Bioventures Inc.
Volociximab Phase II clinical trials Pancreatic cancer Cancer drugs PDL BioPharma Inc.,
Biogen Idec Inc.
Volociximab Phase II clinical trials Renal cell cancer Cancer drugs PDL BioPharma Inc.,
Biogen Idec Inc.
Volociximab Phase II clinical trials Metastatic melanoma Cancer drugs PDL BioPharma Inc.,
Biogen Idec Inc.
Volociximab Phase II clinical trials Non-small cell lung cancer Cancer drugs PDL BioPharma Inc.,
Biogen Idec Inc.
Volociximab Phase II clinical trials Ovarian cancer Cancer drugs PDL BioPharma Inc.,
Biogen Idec Inc.
Voreloxin Phase II clinical trials Acute myeloid leukemia Cancer drugs Sunesis Pharmaceuticals Inc.
Voreloxin Phase II clinical trials Ovarian cancer Cancer drugs Sunesis Pharmaceuticals Inc.
VP101 Phase II clinical trials Cancer Cancer drugs MacroChem Corp.
VP700 Phase I clinical trials Cancer Cancer drugs MacroChem Corp.
VQD-002 Phase I/II clinical trials Solid tumors Cancer drugs VioQuest
VQD-002 Phase I/II clinical trials Hematological malignancies Cancer drugs VioQuest
VQD-002 Phase I/II clinical trials Multiple myeloma Cancer drugs VioQuest
VT-122 Phase II clinical trials Cachexia Cancer drugs Vicus Therapeutics
VX-689/MK-5108 Phase I clinical trials Tumors Cancer drugs Vertex Pharmaceuticals Inc.,
Merck & Co.
WX-UK1 Phase I clinical trials Solid tumors Cancer drugs Wilex AG
WX-UK1 Phase I clinical trials Breast cancer Cancer drugs Wilex AG
Xcytrin Awaiting approval Non-small cell lung cancer Cancer drugs Pharmacyclics Inc.
Xcytrin Phase I/II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Pharmacyclics Inc.
Xcytrin Phase II clinical trials Renal cell cancer Cancer drugs Pharmacyclics Inc.
Xcytrin Phase II clinical trials Low-grade non-Hodgkin’s Cancer drugs Pharmacyclics Inc.
lymphoma
Xeloda Phase III clinical trials Breast cancer Cancer drugs Hoffmann-La Roche Inc.
Xeloda Awaiting approval Colorectal cancer Cancer drugs Hoffmann-La Roche Inc.
Xelox Awaiting approval Colorectal cancer Cancer drugs Hoffmann-La Roche Inc.
XL019 Phase I clinical trials Myeloproliferative disorders Cancer drugs Exelixis Inc.
XL147 Phase I clinical trials Solid tumors Cancer drugs Exelixis Inc.
XL184 Phase I/II clinical trials Non-small cell lung cancer Cancer drugs Exelixis Inc.
XL184 Phase II clinical trials Glioblastoma multiforme Cancer drugs Exelixis Inc.
XL184 Phase III clinical trials Medullary thyroid cancer Cancer drugs Exelixis Inc.
XL228 Phase I clinical trials Chronic myelogenous Cancer drugs Exelixis Inc.
leukemia
XL228 Phase I clinical trials Acute lymphocytic leukemia Cancer drugs Exelixis Inc.
XL228 Phase I clinical trials Advanced malignancies Cancer drugs Exelixis Inc.
XL647 Phase II clinical trials Non-small cell lung cancer Cancer drugs Exelixis Inc.
XL820 Phase II clinical trials Gastrointestinal stromal tumor Cancer drugs Exelixis Inc.
XmAb 2513 Phase I clinical trials Hodgkin’s lymphoma Cancer drugs Xencor Inc.
XmAb 2513 Phase I clinical trials T-cell lymphoma Cancer drugs Xencor Inc.
33
Developer/partner
developer
XmAb 2513 Phase I clinical trials Anaplastic large cell Cancer drugs Xencor Inc.
lymphoma
XMT-1001 Phase I clinical trials Solid tumors Cancer drugs Mersana Therapeutics Inc.
XRP6258 Phase III clinical trials Prostate cancer Cancer drugs Sanofi-Aventis
XRP6258/ Larotaxel Phase II clinical trials Breast cancer Cancer drugs Sanofi-Aventis
Combination
Xyotax Phase III clinical trials Non-small cell lung cancer Cancer drugs Cell Therapeutics Inc.,
Novartis Pharmaceuticals
Corp.
Xyotax Phase III clinical trials Ovarian cancer Cancer drugs Cell Therapeutics Inc.
Xyotax Phase I clinical trials Esophageal cancer Cancer drugs Cell Therapeutics Inc.
Xyotax Phase I clinical trials Gastric cancer Cancer drugs Cell Therapeutics Inc.
Xyotax Phase II clinical trials Prostate cancer Cancer drugs Cell Therapeutics Inc.
YM155 Phase II clinical trials Hormone-refractory prostate Cancer drugs Astellas Pharma US Inc.
cancer
YM155 Phase II clinical trials Non-small cell lung cancer Cancer drugs Astellas Pharma US Inc.
YM155 Phase II clinical trials Metastatic melanoma Cancer drugs Astellas Pharma US Inc.
YM155 Phase II clinical trials Non-Hodgkin’s lymphoma Cancer drugs Astellas Pharma US Inc.
Yondelis Phase III clinical trials Ovarian cancer Cancer drugs PharmaMar USA Inc.,
Johnson & Johnson
Development
Zactima Phase III clinical trials Non-small cell lung cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
Zactima Phase II clinical trials Medullary thyroid cancer Cancer drugs AstraZeneca
Pharmaceuticals LP
ZD4054 Phase III clinical trials Hormone resistant prostate Cancer drugs AstraZeneca
cancer Pharmaceuticals LP
Zevalin Awaiting approval Follicular non-Hodgkin’s Cancer drugs Cell Therapeutics Inc.
lymphoma
ZIO-101 Phase II clinical trials Solid tumors Cancer drugs Ziopharm Oncology Inc.
ZIO-101 Phase II clinical trials Hematologic cancer Cancer drugs Ziopharm Oncology Inc.
ZIO-101 Phase II clinical trials Multiple myeloma Cancer drugs Ziopharm Oncology Inc.
ZIO-101 Phase II clinical trials Liver cancer Cancer drugs Ziopharm Oncology Inc.
ZIO-101 Oral Phase I clinical trials Solid tumors Cancer drugs Ziopharm Oncology Inc.
ZK-PRA Phase II clinical trials Breast cancer Cancer drugs Bayer HealthCare
Zolinza Phase III clinical trials Pleural mesothelioma Cancer drugs Merck & Co.
Zybrestat Phase III clinical trials Thyroid cancer Cancer drugs Oxigene Inc.
Zybrestat Phase II clinical trials Ovarian cancer Cancer drugs Oxigene Inc.
Zybrestat Phase I clinical trials Solid tumors Cancer drugs Oxigene Inc.
Zybrestat Phase II clinical trials Non-small cell lung cancer Cancer drugs Oxigene Inc.
ZYC300 Phase I/II clinical trials Solid tumors Cancer drugs MGI Pharma Inc.
34
TOP 15 THERAPEUTIC GROUPS: CENTRAL NERVOUS SYSTEM
Developer/partner
developer
1014802 Phase I clinical trials Bipolar disorder Psychotherapeutic agents GlaxoSmithKline Inc.
1018921 Phase I clinical trials Schizophrenia Psychotherapeutic agents GlaxoSmithKline Inc.
163090 Phase I clinical trials Depression Psychotherapeutic agents GlaxoSmithKline Inc.
163090 Phase I clinical trials Anxiety Psychotherapeutic agents GlaxoSmithKline Inc.
189254 Phase II clinical trials Narcolepsy Neurological disorder GlaxoSmithKline Inc.
239512 Phase I clinical trials Dementia Dementia treatments GlaxoSmithKline Inc.
249320 Phase I clinical trials Neuronal injury Neurological disorder GlaxoSmithKline Inc.
274150 Phase II clinical trials Migraine Migraine drugs GlaxoSmithKline Inc.
372475 Phase II clinical trials Depression Psychotherapeutic agents GlaxoSmithKline Inc.
598809 Phase I clinical trials Drug dependency Drug dependency therapies GlaxoSmithKline Inc.
618334 Phase I clinical trials Drug dependency Drug dependency therapies GlaxoSmithKline Inc.
649868 Phase II clinical trials Sleep disorders Sleep-disorder treatment GlaxoSmithKline Inc.
681323 Phase II clinical trials Neuropathic pain Central nervous system GlaxoSmithKline Inc.
disorders
729327 Phase I clinical trials Schizophrenia Psychotherapeutic agents GlaxoSmithKline Inc.
742457 Phase II clinical trials Dementia Dementia treatments GlaxoSmithKline Inc.
773812 Phase II clinical trials Schizophrenia Psychotherapeutic agents GlaxoSmithKline Inc.
856553 Phase II clinical trials Depression Psychotherapeutic agents GlaxoSmithKline Inc.
876008 Phase II clinical trials Anxiety Psychotherapeutic agents GlaxoSmithKline Inc.,
Neurocrine Biosciences Inc.
876008 Phase II clinical trials Depression Psychotherapeutic agents GlaxoSmithKline Inc.,
933776 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies GlaxoSmithKline Inc.
A-Beta Antibody Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Eli Lilly and Co.
Abilify Phase III clinical trials Autistic disorder Psychotherapeutic agents Otsuka America
Pharmaceutical Inc.,
ABT-089 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Abbott Laboratories
ABT-089 Phase II clinical trials Attention-deficit Psychotherapeutic agents Abbott Laboratories
hyperactivity disorder
ABT-107 Phase I clinical trials Cognitive disorders Psychotherapeutic agents Abbott Laboratories
ABT-894 Phase II clinical trials Diabetic neuropathic pain Central nervous system Abbott Laboratories
disorders
ABT-894 Phase II clinical trials Attention-deficit Psychotherapeutic agents Abbott Laboratories
hyperactivity disorder
AC-1202 Phase II clinical trials Age-associated memory Memory impairment therapies Accera Inc.
impairment
AC-3933 Phase II clinical trials Dementia Dementia treatments Dainippon Sumitomo
Pharma Co.
35
Developer/partner
developer
ACC-001 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Elan Pharmaceuticals Inc.,
Acetyl-L-carnitine Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies Sigma-Tau
AD-5423 Phase II clinical trials Schizophrenia Psychotherapeutic agents Dainippon Sumitomo
Pharma Co.
Adenosine 2a Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Schering-Plough Corp.
Receptor Antagonist
Adipiplon Phase II/III clinical trials Insomnia Sleep-disorder treatment Neurogen Corp.
ADL5859 Phase II clinical trials Diabetic neuropathic pain Central nervous system Adolor Corp.,
disorders Pfizer Inc.
Adlea Phase II clinical trials Neuropathic pain Central nervous system Anesiva Inc.
disorders
AEOL 10150 Phase I clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Aeolus Pharmaceuticals Inc.
drugs
AFQ056 Phase I clinical trials Anxiety Psychotherapeutic agents Novartis
AGO178 Phase III clinical trials Major depressive disorder Psychotherapeutic agents Novartis
AL-02 Phase III clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Avicena Group Inc.
drugs
AL-108 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Allon Therapeutics Inc.
AL-108 Phase II clinical trials Schizophrenia Psychotherapeutic agents Allon Therapeutics Inc.
Almorexant Phase III clinical trials Primary insomnia Sleep-disorder treatment Actelion Pharmaceuticals US
Alpha Agonist Phase II clinical trials Neuropathic pain Central nervous system Allergan Inc.,
disorders Acadia Pharmaceuticals Inc.
ALS-08 Phase II clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Avicena Group Inc.
drugs
Alzhemed Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies Bellus Health Inc.
Aminopyridine Phase II clinical trials Guillain Barr syndrome Neurological disorder Acorda Therapeutics Inc.
Ampakine Phase II clinical trials Depression Psychotherapeutic agents Schering-Plough Corp.
AMR101 Phase II clinical trials Depression Psychotherapeutic agents Amarin Corporation Plc.
Anti-Abeta Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Genentech Inc.
APD125 Phase II clinical trials Insomnia Sleep-disorder treatment Arena Pharmaceuticals Inc.
Aplindore Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Neurogen Corp.
Aplindore Phase II clinical trials Restless legs syndrome Muscle relaxants Neurogen Corp.
Aricept Awaiting approval Vascular dementia Dementia treatments Eisai Inc.
Aricept Phase II clinical trials Dementia with Lewy bodies Dementia treatments Eisai Inc.
Aricept Sustained Release Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies Eisai Inc.
AS-3201 Phase III clinical trials Diabetic neuropathy Central nervous system Eisai Inc.
disorders
Asenapine Awaiting approval Acute mania Psychotherapeutic agents Schering-Plough Corp.
Asenapine Awaiting approval Schizophrenia Psychotherapeutic agents Schering-Plough Corp.
ASP2535 Phase I clinical trials Schizophrenia Psychotherapeutic agents Astellas Pharma US Inc.
ASP2535 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Astellas Pharma US Inc.
ASP2905 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Astellas Pharma US Inc.
ASP2905 Phase I clinical trials Schizophrenia Psychotherapeutic agents Astellas Pharma US Inc.
ATI-9242 Phase I clinical trials Psychiatric disorders Psychotherapeutic agents Aryx Therapeutics Inc.
ATI355 Phase II clinical trials Acute spinal cord injury Spinal cord treatments Novartis
AV411 Phase I clinical trials Neuropathic pain Central nervous system Avigen Inc.
disorders
36
Developer/partner
developer
AV650 Phase II clinical trials Disabling neuromuscular Nervous system and muscle Avigen Inc.
spasm disorder therapies
AVE0657 Phase I clinical trials Sleep apnea Sleep-disorder treatment Sanofi-Aventis
AVE1625 Phase II clinical trials Schizophrenia Psychotherapeutic agents Sanofi-Aventis
AVE8112 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Sanofi-Aventis
AZ-001 Phase II clinical trials Migraine Migraine drugs Alexza Pharmaceuticals Inc.
AZ-002 Phase II clinical trials Panic attacks Psychotherapeutic agents Alexza Pharmaceuticals Inc.
AZ-004 Phase III clinical trials Agitation associated with Psychotherapeutic agents Alexza Pharmaceuticals Inc.
schizophrenia
AZ-007 Phase I clinical trials Sleep disorders Sleep-disorder treatment Alexza Pharmaceuticals Inc.
AZ-104 Phase II clinical trials Migraine Migraine drugs Alexza Pharmaceuticals Inc.
AZD0328 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies AstraZeneca
Pharmaceuticals LP
AZD1386 Phase II clinical trials Chronic nociceptive pain Central nervous system AstraZeneca
disorders Pharmaceuticals LP
AZD1704 Phase I clinical trials Analgesia Central nervous system AstraZeneca
AZD1940 Phase II clinical trials Neuropathic pain Central nervous system AstraZeneca
AZD2066 Phase I clinical trials Chronic nociceptive pain Central nervous system AstraZeneca
AZD2327 Phase I clinical trials Anxiety Psychotherapeutic agents AstraZeneca
Pharmaceuticals LP
AZD2327 Phase I clinical trials Depression Psychotherapeutic agents AstraZeneca
Pharmaceuticals LP
AZD2624 Phase II clinical trials Schizophrenia Psychotherapeutic agents AstraZeneca
Pharmaceuticals LP
AZD3241 Phase I clinical trials Parkinson’s disease Parkinson’s disease therapies AstraZeneca Pharmaceuticals
LP
AZD3480 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies AstraZeneca Pharmaceuticals
LP
AZD3480 Phase II clinical trials Cognitive disorders in Psychotherapeutic agents AstraZeneca Pharmaceuticals
schizophrenia LP
AZD3480 Phase II clinical trials Attention-deficit hyperactivity Psychotherapeutic agents AstraZeneca Pharmaceuticals
disorder LP
AZD6280 Phase I clinical trials Anxiety Psychotherapeutic agents AstraZeneca Pharmaceuticals
LP
AZD6765 Phase II clinical trials Depression Psychotherapeutic agents AstraZeneca Pharmaceuticals
LP
AZD7325 Phase I clinical trials Anxiety Psychotherapeutic agents AstraZeneca Pharmaceuticals
LP
Azilect Phase III clinical trials Parkinson’s disease Parkinson’s disease therapies Teva Pharmaceuticals USA
Inc.
Bapineuzumab I.V. Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies Elan Pharmaceuticals Inc.,
Bapineuzumab SC Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Elan Pharmaceuticals Inc.,
BCI-540 Phase II clinical trials Major depressive disorder Central nervous system BrainCells Inc.
disorders
BGC20-0166 Phase II clinical trials Obstructive sleep apnea Sleep-disorder treatment BTG International Inc.
BGC20-1531 Phase I clinical trials Migraine Migraine drugs BTG International Inc.
BGG492 Phase I clinical trials Epilepsy Anticonvulsants Novartis Pharmaceuticals
Corp.
BIA 2-093 Phase III clinical trials Epilepsy Anticonvulsants Sepracor Inc.
Bicifadine Phase II clinical trials Neuropathic pain Central nervous system XTL Biopharmaceuticals Inc.
disorders
37
Developer/partner
developer
Bifeprunox Phase III clinical trials Schizophrenia Psychotherapeutic agents Solvay Pharmaceuticals Inc.
BL-1020 Phase II clinical trials Schizophrenia Psychotherapeutic agents BioLineRx Ltd.
Botox Phase III clinical trials Migraine Migraine drugs Allergan Inc.
Brivaracetam Phase III clinical trials Refractory partial-onset Anticonvulsants UCB Pharma Inc.
epilepsy
CAD106 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Novartis
Carbetocin Phase I clinical trials Autistic disorder Psychotherapeutic agents MDRNA Inc.
Cariprazine Phase II clinical trials Schizophrenia Psychotherapeutic agents Forest Laboratories Inc.
Cariprazine Phase II clinical trials Bipolar mania Psychotherapeutic agents Forest Laboratories Inc.
Carisbamate Awaiting approval Partial-onset seizure Anticonvulsants Johnson & Johnson
Development
Casopitant Phase II clinical trials Depression Psychotherapeutic agents GlaxoSmithKline Inc.
Casopitant Phase II clinical trials Anxiety Psychotherapeutic agents GlaxoSmithKline Inc.
Catena Phase III clinical trials Friedreich ataxia Central nervous system Santhera
disorders Pharmaceuticals AG
CERE-110 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Ceregene Inc.
CERE-120 Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Ceregene Inc.,
Genzyme Corp.
Cethrin Phase I/II clinical trials Spinal cord injury Spinal cord treatments Alseres Pharmaceuticals Inc.
Clobazam Phase III clinical trials Lennox-Gastaut syndrome Anticonvulsants Ovation Pharmaceuticals Inc.
Clonicel Phase III clinical trials Attention-deficit hyperactivity Psychotherapeutic agents Sciele Pharma Inc.
disorder
CNS 7056 Phase I clinical trials Sedation Sedatives Cenes Pharmaceuticals Plc.
COL-144 Phase II clinical trials Migraine Migraine drugs CoLucid Pharmaceuticals Inc.
Corlux Phase III clinical trials Psychotic major depression Psychotherapeutic agents Corcept Therapeutics Inc.
CRF Antagonist Phase I clinical trials Affective disorders Psychotherapeutic agents Bristol-Myers Squibb Co.
CTS-21166 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies CoMentis Inc.,
Astellas Pharma US Inc.
CX1739 Phase I clinical trials Attention-deficit hyperactivity Psychotherapeutic agents Cortex Pharmaceuticals Inc.
disorder
CX717 Phase II clinical trials Attention-deficit hyperactivity Psychotherapeutic agents Cortex Pharmaceuticals Inc.
disorder
CX717 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Cortex Pharmaceuticals Inc.
Daytrana Phase III clinical trials Attention-deficit hyperactivity Psychotherapeutic agents Noven Pharmaceuticals Inc.,
disorder Shire US Inc.
DDS-04A Awaiting approval Major depressive disorder Central nervous system Labopharm Inc.
disorders
DEBIO-9902 SR Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Debiopharm SA
Dimebon Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies Pfizer Inc., Medivation Inc.
DOV 102,677 Phase II clinical trials Depression Psychotherapeutic agents DOV Pharmaceutical Inc.
DOV 21,947 Phase II clinical trials Depression Psychotherapeutic agents DOV Pharmaceutical Inc.
Duodopa Phase III clinical trials Parkinson’s disease Parkinson’s disease therapies Solvay Pharmaceuticals Inc.
Dysport Awaiting approval Cervical dystonia Cervical dystonia therapies Ipsen Inc.
E2007 Phase III clinical trials Epilepsy Anticonvulsants Eisai Inc.
E2007 Phase II clinical trials Migraine Migraine drugs Eisai Inc.
E2007 Phase II clinical trials Neuropathic pain Central nervous system Eisai Inc.
disorders
E2012 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Eisai Inc.
E2508 Phase I clinical trials Depression Psychotherapeutic agents Eisai Inc.
ELND-005/AZD-103 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Transition Therapeutics Inc.,
Elan Pharmaceuticals Inc.
38
Developer/partner
developer
EpiCept NP-1 Phase III clinical trials Diabetic peripheral Central nervous system EpiCept Corp.
neuropathy disorders
EpiCept NP-1 Phase III clinical trials Peripheral herpetic Central nervous system EpiCept Corp.
Eplivanserin Phase III clinical trials Chronic insomnia Sleep-disorder treatment Sanofi-Aventis
Esmirtazapine Phase III clinical trials Insomnia Sleep-disorder treatment Schering-Plough Corp.
EVP-6124 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies EnVivo Pharmaceuticals Inc.
EVP-6124 Phase I clinical trials Schizophrenia Psychotherapeutic agents EnVivo Pharmaceuticals Inc.
EVT 201 Phase II clinical trials Insomnia Sleep-disorder treatment Evotec NeuroSciences GmbH
EVT 201 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Evotec NeuroSciences GmbH
EVT 201 Phase I clinical trials Neuropathic pain Central nervous system Evotec NeuroSciences GmbH
disorders
Exebryl-1 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies ProteoTech Inc.
Fospropofol Awaiting approval Conscious sedation Anesthetics MGI Pharma Inc.
Gabapentin GR Phase II clinical trials Diabetic peripheral Central nervous system DepoMed Inc.
Gammagard Liquid Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Baxter Healthcare Corp.
Ganaxolone Phase II clinical trials Partial-onset seizure Anticonvulsants Marinus Pharmaceuticals Inc.
Ganaxolone Phase II clinical trials Infantile spasms Anticonvulsants Marinus Pharmaceuticals Inc.
Gantacurium Phase II clinical trials Anesthesia Anesthetics Avera Pharmaceuticals Inc.
Gene Therapy Phase I clinical trials Parkinson’s disease Parkinson’s disease therapies Genzyme Corp.
Geodon Phase III clinical trials Bipolar depression Psychotherapeutic agents Pfizer Inc.
Geodon Phase III clinical trials Bipolar relapse prevention Psychotherapeutic agents Pfizer Inc.
Gepirone ER Awaiting approval Major depressive disorder Psychotherapeutic agents GlaxoSmithKline Inc., Fabre
Kramer Pharmaceuticals Inc.
Glycine Uptake Inhibitor Phase II clinical trials Schizophrenia Psychotherapeutic agents Schering-Plough Corp.
Glypromate Phase III clinical trials Cognitive impairment Cognitive-impairment Neuren Pharmaceuticals Ltd.
therapies
GlyT-1 Phase I clinical trials Schizophrenia Psychotherapeutic agents NPS Pharmaceuticals Inc.,
Janssen LP
GPI 1485 Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Symphony Neuro
Development Co.
GTS-21 Phase II clinical trials Cognitive disorders Psychotherapeutic agents CoMentis Inc.
H.P. Acthar Gel Awaiting approval Infantile spasms Spasticity treatments Questcor Pharmaceuticals
Inc.
HGT-1111 Phase II/III clinical trials Meatchromatic Neurological disorder Shire US Inc.
leukodystrophy
Huperzine A Oral Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Neuro-Hitech
ICA-105665 Phase I clinical trials Epilepsy Anticonvulsants Icagen Inc.
Indiplon-IR Awaiting approval Insomnia Sleep-disorder treatment Neurocrine Biosciences Inc.
Intermezzo Awaiting approval Insomnia Sleep-disorder treatment Transcept Pharmaceuticals
Inc.
Intranasal Midazolam Phase I clinical trials Seizures Anticonvulsants Intranasal Therapeutics Inc.
Intravenous Phase III clinical trials Epilepsy Anticonvulsants Ovation Pharmaceuticals Inc.
Carbamazepine
Intuniv Awaiting approval Attention-deficit hyperactivity Psychotherapeutic agents Shire US Inc.
disorder
Invega Phase III clinical trials Bipolar mania Psychotherapeutic agents Johnson & Johnson
Development
Invega Phase III clinical trials Schizoaffective disorder Psychotherapeutic agents Johnson & Johnson
Development
39
Developer/partner
developer
IPX056 Phase III clinical trials Spasticity associated with Nervous system and muscle Impax Laboratories Inc.
multiple sclerosis disorder therapies
Isis 333611 Phase I clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Isis Pharmaceuticals Inc.
drugs
Istradefylline Awaiting approval Parkinson’s disease Parkinson’s disease therapies Kyowa Hakko Kirin Co.
ITI-007 Phase I clinical trials Schizophrenia Central nervous system Intra-Cellular Therapies Inc.
disorders
ITI-722 Phase II clinical trials Insomnia Sleep-disorder treatment Intra-Cellular Therapies Inc.
JP-1730 Phase II clinical trials Dyskinesia Parkinson’s disease therapies Santhera
Pharmaceuticals AG
JZP-4 Phase I clinical trials Epilepsy Anticonvulsants Jazz Pharmaceuticals Inc.
JZP-4 Phase I clinical trials Bipolar disorder Psychotherapeutic agents Jazz Pharmaceuticals Inc.
JZP-8 Phase II clinical trials Seizures Anticonvulsants Jazz Pharmaceuticals Inc.
KD7040 Phase I clinical trials Neuropathic pain Central nervous system Kalypsys Inc.
disorders
KD7040 Phase I clinical trials Neuropathic pain Central nervous system Kalypsys Inc.
disorders
Keppra Awaiting approval Partial-onset seizure Anticonvulsants UCB Pharma Inc.
Keppra XR Phase III clinical trials Epilepsy Anticonvulsants UCB Pharma Inc.
Ketasyn Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Accera Inc.
KNS-760704 Phase II clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Knopp Neurosciences Inc.
drugs
KRN5500 Phase II clinical trials Neuropathic pain Central nervous system DARA BioSciences Inc.
disorders
Lacosamide Phase II clinical trials Migraine Migraine drugs UCB Pharma Inc.
Lamictal XR Phase III clinical trials Partial generalized Anticonvulsants GlaxoSmithKline Inc.
tonic-clonic seizures
Lamictal XR Awaiting approval Epilepsy-partial seizures Anticonvulsants GlaxoSmithKline Inc.
Lexapro Awaiting approval Major depressive disorder Psychotherapeutic agents Forest Laboratories Inc.
Lithium QD Phase III clinical trials Bipolar disorder Psychotherapeutic agents Noven Pharmaceuticals Inc.
Lu AA21004 Phase III clinical trials Major depressive disorder Psychotherapeutic agents H. Lundbeck AS,
North America Inc.
Lu AA21004 Phase III clinical trials General anxiety disorder Psychotherapeutic agents H. Lundbeck AS,
North America Inc.
Lu AA24530 Phase II clinical trials Depression Psychotherapeutic agents H. Lundbeck AS,
North America Inc.
LX6171 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Lexicon Pharmaceuticals Inc.
LX6171 Phase II clinical trials Cognitive disorders Psychotherapeutic agents Lexicon Pharmaceuticals Inc.
LY2062430 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Eli Lilly and Co.
LY2624803 Phase II clinical trials Insomnia Sleep-disorder treatment Eli Lilly and Co.
LY450139 Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies Eli Lilly and Co.
Lyrica Phase III clinical trials Generalized anxiety disorder Psychotherapeutic agents Pfizer Inc.
Lyrica Phase III clinical trials Epilepsy Psychotherapeutic agents Pfizer Inc.
Lyrica Phase II clinical trials Restless legs syndrome Muscle relaxants Pfizer Inc.
MAP0004 Phase III clinical trials Migraine Migraine drugs MAP Pharmaceuticals Inc.
MCC-257 Phase II clinical trials Diabetic polyneuropathy Neurological disorder Mitsubishi Tanabe
Pharma Corp.
Melperone Phase II clinical trials Parkinson’s disease psychosis Parkinson’s disease therapies Ovation Pharmaceuticals Inc.
MEM 1003 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Memory
40
Developer/partner
developer
MEM 1414 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Memory
MEM 63908/ R4996 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Memory Pharmaceuticals
Corp., Roche Laboratories Inc.
mGlu2/3 Receptor Agonist Phase II clinical trials Schizophrenia Psychotherapeutic agents Eli Lilly and Co.
mGluR2/3 Phase I clinical trials Schizophrenia Psychotherapeutic agents Pfizer Inc.
mGluRs Phase I clinical trials Central nervous system Central nervous system NPS Pharmaceuticals Inc.
disorders disorders
MK-0249 Phase II clinical trials Neurological disorders Psychotherapeutic agents Merck & Co.
MK-0249 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Merck & Co.
MK-0249 Phase II clinical trials Psychiatric disorders Psychotherapeutic agents Merck & Co.
MK-0657 Phase I clinical trials Parkinson’s disease Parkinson’s disease therapies Merck & Co.
MK-4305 Phase I clinical trials Neurological disorders Neurological disorder Merck & Co.
MK-5757 Phase I clinical trials Psychiatric diseases Psychotherapeutic agents Merck & Co.
MK-8998 Phase I clinical trials Neurological disorders Neurological disorder Merck & Co.
MN-305 Phase II/III clinical trials Generalized anxiety disorder Psychotherapeutic agents MediciNova Inc.
MN-305 Phase II clinical trials Insomnia Sleep-disorder treatment MediciNova Inc.
Motiva Phase II clinical trials Cognitive disorders Psychotherapeutic agents Neuren Pharmaceuticals Ltd.
Myogane Phase I clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Phytopharm Plc.
drugs
Namenda Awaiting approval Alzheimer’s disease Alzheimer’s disease therapies Forest Laboratories Inc.
Namenda Modified-Release Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies Forest Laboratories Inc.
Neramexane Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Forest Laboratories Inc.,
Merz Pharmaceuticals Inc.
NERI Phase II clinical trials Depression Psychotherapeutic agents Eli Lilly and Co.
Neupro Awaiting approval Restless legs syndrome Muscle relaxants UCB Pharma Inc.
Neupro Awaiting approval Parkinson’s disease Parkinson’s disease therapies UCB Pharma Inc.
NGX-1998 Phase I clinical trials Neuropathic pain Central nervous system NeurogesX Inc.
disorders
NGX267 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies TorreyPines Therapeutics Inc.
NGX267 Phase I clinical trials Schizophrenia Psychotherapeutic agents TorreyPines Therapeutics Inc.
NGX426 Phase II clinical trials Migraine Migraine drugs TorreyPines Therapeutics Inc.
NGX426 Phase I clinical trials Neuropathic pain Central nervous system TorreyPines Therapeutics Inc.
disorders
NGX426 Phase I clinical trials Hyperalgesia Central nervous system TorreyPines Therapeutics Inc.
disorders
NH001 Phase II clinical trials Post-traumatic coma Neurological disorder NeuroHealing
NIC5-15 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Humanetics Corp.
NLX-P101 Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Neurologix Inc.
NP101 Phase III clinical trials Migraine Migraine drugs NuPathe Inc.
Nuvigil Phase II clinical trials Bipolar depression Psychotherapeutic agents Cephalon Inc.
Nuvigil Phase II clinical trials Schizophrenia Psychotherapeutic agents Cephalon Inc.
Nuvigil Phase III clinical trials Excessive sleepiness Sleep-disorder treatment Cephalon Inc.
OMS201 Phase I clinical trials Muscle relaxation Muscle relaxants Omeros Corp.
Once Daily Trazodone Awaiting approval Major depressive disorder Psychotherapeutic agents Labopharm Inc.
Orvepitant Phase I clinical trials Depression Psychotherapeutic agents GlaxoSmithKline Inc.
Orvepitant Phase I clinical trials Anxiety Psychotherapeutic agents GlaxoSmithKline Inc.
Oxigon Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Intellect Neurosciences Inc.
Pagoclone Phase II clinical trials Persistent development Psychotherapeutic agents Indevus Pharmaceuticals Inc.
stuttering
41
Developer/partner
developer
Paliperidone Palmitate IM Awaiting approval Schizophrenia Psychotherapeutic agents Johnson & Johnson
Long Acting Injectable Pharmaceutical Research &
Development
PAZ-417 Oral Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Wyeth Pharmaceuticals
PD-02 Phase III clinical trials Parkinson’s disease Parkinson’s disease therapies Avicena Group Inc.
PD-200390 Phase II clinical trials Insomnia Sleep-disorder treatment Pfizer Inc.
PD-332334 Phase III clinical trials Generalized anxiety disorder Psychotherapeutic agents Pfizer Inc.
PF-217830 Phase II clinical trials Schizophrenia Psychotherapeutic agents Pfizer Inc.
PF-2400013 Phase I clinical trials Schizophrenia Psychotherapeutic agents Pfizer Inc.
PF-2545920 Phase II clinical trials Schizophrenia Psychotherapeutic agents Pfizer Inc.
PF-3049423 Phase I clinical trials Neurorestoration Neurological disorder Pfizer Inc.
PF-3084014 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Pfizer Inc.
PF-3654746 Phase I clinical trials Cognitive disorders in Psychotherapeutic agents Pfizer Inc.
schizophrenia
PF-3654764 Phase I clinical trials Cognitive disorders in Psychotherapeutic agents Pfizer Inc.
schizophrenia
PF-4447943 Phase I clinical trials Alzheimer’s dementia Alzheimer’s disease therapies Pfizer Inc.
PF-4480682 Phase II clinical trials Neuropathic pain Central nervous system Pfizer Inc.
disorders
PF-4494700 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Pfizer Inc.
PH94B Phase II clinical trials Social anxiety disorder Psychotherapeutic agents Pherin Pharmaceuticals Inc.
Pimavanserin Phase II clinical trials Schizophrenia Psychotherapeutic agents Acadia Pharmaceuticals Inc.
Pimavanserin Phase III clinical trials Parkinson’s disease psychosis Psychotherapeutic agents Acadia Pharmaceuticals Inc.
Pimavanserin Phase I clinical trials Sleep maintenance insomnia Sleep-disorder treatment Acadia Pharmaceuticals Inc.
Posiphen Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies TorreyPines Therapeutics Inc.
Pristiq Phase III clinical trials Neuropathic pain Central nervous system Wyeth Pharmaceuticals
disorders
PRO-513 Awaiting approval Migraine Migraine drugs Kowa Pharmaceuticals
America
PRX-03140 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Epix Pharmaceuticals Inc.
PRX-07034 Phase II clinical trials Cognitive impairment Cognitive-impairment Epix Pharmaceuticals Inc.
therapies
QR-333 Phase II clinical trials Diabetic peripheral Central nervous system Quigley Pharma Inc.
R1450 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Hoffmann-La Roche Inc.
R1678 Phase II clinical trials Schizophrenia Psychotherapeutic agents Hoffmann-La Roche Inc.
R3487/MEM 3454 Phase II clinical trials Cognitive impairment Alzheimer’s disease therapies Roche Laboratories Inc.
associated with schizophrenia
R3487/MEM 3454 Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Roche Laboratories Inc.
Reloxin Awaiting approval Poststroke muscular spasticity Spasticity treatments Medicis Aesthetics Inc.
Requip Extended Release Awaiting approval Restless legs syndrome Muscle relaxants GlaxoSmithKline Inc.
Retigabine Phase III clinical trials Epilepsy Anticonvulsants GlaxoSmithKline Inc.
RG2417 (Uridine) Phase II clinical trials Bipolar depression Psychotherapeutic agents Repligen Corp.
Risperdal Consta Awaiting approval Bipolar disorder Psychotherapeutic agents Johnson & Johnson
Development
Rosiglitazone XR Phase III clinical trials Alzheimer’s disease Alzheimer’s disease therapies GlaxoSmithKline Inc.
Rotigotine Nasal Spray Phase II clinical trials Restless legs syndrome Muscle relaxants UCB Pharma Inc.
42
Developer/partner
developer
Rufinamide Awaiting approval Partial-onset seizures Anticonvulsants Eisai Inc.
Rufinamide Awaiting approval Lennox-Gastaut syndrome Anticonvulsants Eisai Inc.
S,S-Reboxetine Phase III clinical trials Fibromyalgia Fibromyalgia treatments Pfizer Inc.
Sabcomeline Phase II clinical trials Schizophrenia Psychotherapeutic agents Minster Pharmaceuticals
Sabril Awaiting approval Refractory complex partial Anticonvulsants Ovation Pharmaceuticals Inc.
seizures
Sabril Awaiting approval Infantile spasms Anticonvulsants Ovation Pharmaceuticals Inc.
SAM-531 Oral Phase II clinical trials Alzheimer’s disease Alzheimer’s disease therapies Wyeth Pharmaceuticals
SAR102779 Phase I clinical trials Depression Psychotherapeutic agents Sanofi-Aventis
SAR102779 Phase I clinical trials Irritable bowel syndrome Gastrointestinal drugs Sanofi-Aventis
Saredutant Phase III clinical trials Depression Psychotherapeutic agents Sanofi-Aventis
Saredutant Phase III clinical trials Anxiety Psychotherapeutic agents Sanofi-Aventis
Sativex Phase III clinical trials Neuropathic pain Central nervous system Otsuka Pharmaceutical
disorders Development &
Commercialization Inc.
SB-509 Phase II clinical trials Diabetic neuropathy Central nervous system Sangamo Biosciences Inc.
disorders
SB-509 Phase II clinical trials Amyotrophic lateral sclerosis Central nervous system Sangamo Biosciences Inc.
disorders
Selective Norepinephrine Phase I clinical trials Neuropathic pain Central nervous system Neurocrine Biosciences Inc.
Reuptake Inhibitor disorders
SEP-225289 Phase II clinical trials Major depressive disorder Psychotherapeutic agents Sepracor Inc.
SEP-225441 Phase II clinical trials Generalized anxiety disorder Psychotherapeutic agents Sepracor Inc.
SEP-227162 Phase II clinical trials Depression Psychotherapeutic agents Sepracor Inc.
SEP-228425 Phase I clinical trials Depression Psychotherapeutic agents Sepracor Inc.
SEP-228432 Phase I clinical trials Depression Psychotherapeutic agents Sepracor Inc.
Serdaxin Phase II clinical trials Major depressive disorder Psychotherapeutic agents Rexahn Pharmaceuticals
Serdolect Awaiting approval Schizophrenia Psychotherapeutic agents H. Lundbeck AS
Seroquel XR Awaiting approval Generalized anxiety disorder Psychotherapeutic agents AstraZeneca
Pharmaceuticals LP
Seroquel XR Awaiting approval Major depressive disorder Psychotherapeutic agents AstraZeneca
Pharmaceuticals LP
Silenor Awaiting approval Insomnia Sleep-disorder treatment Somaxon
SLV308 Phase III clinical trials Parkinson’s disease Parkinson’s disease therapies Solvay Pharmaceuticals Inc.
SLV313 Phase II clinical trials Schizophrenia Psychotherapeutic agents Solvay Pharmaceuticals Inc.
SLV314 Phase I clinical trials Schizophrenia Psychotherapeutic agents Solvay Pharmaceuticals Inc.
SM-13496 Phase III clinical trials Schizophrenia Psychotherapeutic agents Dainippon Sumitomo
Pharma Co.
Solzira Awaiting approval Restless legs syndrome Muscle relaxants XenoPort Inc.,
SPD493 Phase I clinical trials Central nervous system Central nervous system Shire US Inc.
disorders disorders
SRT501 Phase I clinical trials Mitochondrial Dementia treatments Sirtris Pharmaceuticals Inc.
encephalopathy lactic
acidosis and stroke-like
episodes
SRx-501 Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Spherics Inc.
SSR103800 Phase I clinical trials Schizophrenia Psychotherapeutic agents Sanofi-Aventis
SSR125543 Phase I clinical trials Depression Psychotherapeutic agents Sanofi-Aventis
SSR125543 Phase I clinical trials Anxiety Psychotherapeutic agents Sanofi-Aventis
SSR180575 Phase II clinical trials Diabetic polyneuropathy Neurological disorder Sanofi-Aventis
SSR180711 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Sanofi-Aventis
43
Developer/partner
developer
SSR180711 Phase I clinical trials Schizophrenia Psychotherapeutic agents Sanofi-Aventis
SSR411298 Phase I clinical trials Anxiety Psychotherapeutic agents Sanofi-Aventis
SSR411298 Phase I clinical trials Depression Psychotherapeutic agents Sanofi-Aventis
Staccato Phase II clinical trials Migraine Migraine drugs Alexza Pharmaceuticals Inc.
Stalevo Awaiting approval Parkinson’s disease Parkinson’s disease therapies Novartis
Sublinox Awaiting approval Insomnia Sleep-disorder treatment Orexo AB
Sumatriptan DosePro Awaiting approval Migraine Migraine drugs Zogenix Inc.
Sumatriptan Oral Spray Phase III clinical trials Migraine Migraine drugs NovaDel Pharma Inc.
Symbyax Awaiting approval Resistant depression Psychotherapeutic agents Eli Lilly and Co.
SYN-111 Phase II clinical trials General anxiety disorder Psychotherapeutic agents Synosia Therapeutics
SYN-111 Phase I clinical trials Bipolar disorder Psychotherapeutic agents Synosia Therapeutics
SYN-114 Phase I clinical trials Cognitive disorders Psychotherapeutic agents Synosia Therapeutics
SYN-115 Phase I clinical trials Parkinson’s disease Parkinson’s disease therapies Synosia Therapeutics
SYN-117 Phase I clinical trials Parkinson’s disease Parkinson’s disease therapies Synosia Therapeutics
T-62 Phase II clinical trials Neuropathic pain Central nervous system King Pharmaceuticals Inc.
disorders
T-817MA Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Toyama USA Inc.
TAK-375 Phase II clinical trials Circadian rhythm sleep Sleep-disorder treatment Takeda Pharmaceuticals
disorder North America Inc.
TAK-428 Phase II clinical trials Diabetic neuropathy Central nervous system Takeda Pharmaceuticals
disorders North America Inc.
Talampanel Phase II clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Teva Pharmaceuticals
drugs USA Inc.
TC-2216 Phase I clinical trials Depression Psychotherapeutic agents Targacept Inc.
TC-2216 Phase I clinical trials Anxiety disorder Psychotherapeutic agents Targacept Inc.
TC-5214 Phase II clinical trials Major depressive disorder Psychotherapeutic agents Targacept Inc.
TC-5619 Phase I clinical trials Cognitive disorders in Psychotherapeutic agents AstraZeneca Pharmaceuticals
schizophrenia LP
TC-6499 Phase I clinical trials Neuropathic pain Central nervous system Targacept Inc.,
disorders GlaxoSmithKline Inc.
Tezampanel Phase II clinical trials Migraine Migraine drugs TorreyPines Therapeutics Inc.
TIK-201 Phase II clinical trials Spinal muscular atrophy Spinal cord treatments Tikvah Therapeutics Inc.
TIK-201 Phase I clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Tikvah Therapeutics Inc.
drugs
TIK-301 Phase II clinical trials Circadian sleep disorders Sedatives Tikvah Therapeutics Inc.
Tonabersat Phase II clinical trials Migraine Migraine drugs Minster Pharmaceuticals
Topamax Awaiting approval Partial-onset seizures Anticonvulsants Johnson & Johnson
Development
Transacin Phase III clinical trials HIV-associated sensory Central nervous system NeurogesX Inc.
Tridmac Phase II clinical trials Depression Psychotherapeutic agents Targacept Inc.
TRO19622 Phase I/II clinical trials Amyotrophic lateral sclerosis Amyotrophic lateral sclerosis Trophos SA
drugs
Tyrima Phase I clinical trials Depression Psychotherapeutic agents CeNeRx BioPharma Inc.
Tyrima Phase II clinical trials Major depressive disorder Psychotherapeutic agents CeNeRx BioPharma Inc.
V1512 Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Vernalis Plc.
V2006/BIIB014 Phase II clinical trials Parkinson’s disease Parkinson’s disease therapies Biogen Idec Inc.
V3381 Phase II clinical trials Neuropathic pain Central nervous system Vernalis Plc.
disorders
V950 Phase I clinical trials Alzheimer’s disease Alzheimer’s disease therapies Merck & Co.
44
Developer/partner
developer
Vabicaserin Phase II clinical trials Schizophrenia Psychotherapeutic agents Wyeth Pharmaceuticals
Vadova Awaiting approval Parkinson’s disease Parkinson’s disease therapies Impax Laboratories Inc.
Vanquix Phase III clinical trials Seizures Anticonvulsants King Pharmaceuticals Inc.
VEC-162 Phase III clinical trials Insomnia Sleep-disorder treatment Vanda Pharmaceuticals Inc.
Vilazodone Phase III clinical trials Depression Psychotherapeutic agents Clinical Data Inc.
Vimpat Phase III clinical trials Diabetic neuropathic pain Central nervous system UCB Pharma Inc.
disorders
Volinanserin Phase III clinical trials Insomnia Sleep-disorder treatment Sanofi-Aventis
VPI-013 Phase II clinical trials Neuropathic pain Central nervous system Pharmos Corp.
disorders
VSF-173 Phase II clinical trials Excessive sleepiness Sleep-disorder treatment Vanda Pharmaceuticals Inc.
Xaliproden Phase III clinical trials Peripheral sensory Central nervous system Sanofi-Aventis
neuropathies disorders
Xiaflex Phase II clinical trials Frozen shoulder syndrome Muscle relaxants Auxilium Pharmaceuticals Inc.
XP13512/ 1838262 Phase II clinical trials Neuropathic pain Central nervous system XenoPort Inc.,
disorders GlaxoSmithKline Inc.
XP13512/ 1838262 Phase II clinical trials Migraine Central nervous system XenoPort Inc., GlaxoSmithKline
disorders Inc.
XP19986 Phase II clinical trials Spasticity Spasticity treatments XenoPort Inc.
XP21279 Phase I clinical trials Parkinson’s disease Parkinson’s disease therapies XenoPort Inc.
Zenvia Awaiting approval Involuntary emotional Neurological disorder Avanir Pharmaceuticals
expression disorder
Zenvia Phase III clinical trials Neuropathic pain Central nervous system Avanir Pharmaceuticals
disorders
ZFP Therapeutic Phase II clinical trials Diabetic neuropathy Central nervous system Sangamo Biosciences Inc.
disorders
Zingo Awaiting approval Anesthesia Anesthetics Anesiva Inc.
Zolpidem Oral Spray Awaiting approval Insomnia Sleep-disorder treatment NovaDel Pharma Inc.
Zyprexa Long Acting Awaiting approval Schizophrenia Psychotherapeutic agents Eli Lilly and Co.
Injection
45
TOP 15 THERAPEUTIC GROUPS: INFECTIONS
Developer/partner
developer
1349572 Phase I clinical trials HIV infections Viral infections GlaxoSmithKline Inc.
580416 Phase I clinical trials Bacterial infection Bacterial infections GlaxoSmithKline Inc.
945237 Phase I clinical trials Bacterial infections Bacterial infections GlaxoSmithKline Inc.
A-007 Phase II clinical trials Intraepithelial lesions Viral infections Tigris Pharmaceuticals Inc.
ABT-333 Phase I clinical trials Hepatitis C Viral infections Abbott Laboratories
ABthrax Phase III clinical trials Anthrax infection Bacterial infections Human Genome
Sciences Inc.
ACE393 Phase II clinical trials Travelers diarrhea Bacterial infections ACE BioSciences AS
Acyclovir Lauriad Phase III clinical trials Oral-facial herpes simplex Viral infections BioAlliance Pharma SA
infections
Ad35HIV-EnvA Phase I clinical trials HIV-1 infection Viral infections GenVec Inc.
AG-707 Phase I clinical trials Genital herpes Viral infections Antigenics Inc.
AgaNase Phase II clinical trials Methicillin-resistant Bacterial infections NovaBay
Staphylococcus aureus Pharmaceuticals Inc.
infection
AGS-004 Phase II clinical trials HIV infection Viral infections Argos Therapeutics Inc.,
Albuferon Phase III clinical trials Hepatitis C Viral infections Novartis Pharmaceuticals
Corp., Human Genome
Sciences Inc.
Alferon LDO Phase I/II clinical trials HIV infection Viral infections Hemispherx Biopharma Inc.
Alinia Tablet Phase II clinical trials Hepatitis C Viral infections Romark Laboratories LC
Alinia Tablet Phase II clinical trials Chronic hepatitis C Viral infections Romark Laboratories LC
Amdoxovir Phase II clinical trials HIV infection Viral infections RFS Pharma LLC
Ampligen Phase II clinical trials HIV infection Viral infections Hemispherx Biopharma Inc.
ANA598 Phase I clinical trials Hepatitis C Viral infections Anadys Pharmaceuticals Inc.
ANA773 Phase I clinical trials Hepatitis C Viral infections Anadys Pharmaceuticals Inc.
Anthim Phase II clinical trials Anthrax infection Bacterial infections EluSys Therapeutics Inc.
Anthrax Immune Globulin Phase I clinical trials Anthrax infection Bacterial infections Cangene Corp.
Arikace Phase II clinical trials Pseudomonas aeruginosa Bacterial infections Transave Inc.
infections
ASP2151 Phase II clinical trials Genital herpes Viral infections Astellas Pharma US Inc.
ASP2151 Phase II clinical trials Herpes zoster Viral infections Astellas Pharma US Inc.
Aurexis Phase II clinical trials Staphylococcus aureus Bacterial infections Inhibitex Inc.
infection
AVX754 Phase III clinical trials HIV infection Viral infections Avexa Ltd.
AZD2836 Phase II clinical trials Hepatitis C Viral infections AstraZeneca
Pharmaceuticals LP
AZD7295 Phase I clinical trials Hepatitis C Viral infections AstraZeneca
Pharmaceuticals LP
BAL8557 Antifungal Phase III clinical trials Fungal infections Fungal infections Basilea Pharmaceutica Ltd.
Bavituximab Anti-Viral Phase I clinical trials Hepatitis C Viral infections Peregrine
Bavituximab Anti-Viral Phase I clinical trials HIV infection Viral infections Peregrine
Belerofon Phase I clinical trials Chronic hepatitis C Viral infections Nautilus Biotech
Bevirimat Phase II clinical trials HIV infection Viral infections Panacos
Bioral Amphotericin B Phase I clinical trials Fungal infections Fungal infections BioDelivery Sciences
International Inc.
Boceprevir Phase III clinical trials Hepatitis C Viral infections Schering-Plough Corp.
Botulism Antitoxin Phase I clinical trials Botulism Bacterial infections Cangene Corp.
Camvia Phase III clinical trials Cytomegalovirus infection Viral infections ViroPharma Inc.
46
Developer/partner
developer
CB5300 Phase I clinical trials Hepatitis C Viral infections Canopus BioPharma Inc.
CBR-2092 Phase I clinical trials Bacterial infection Bacterial infections Cumbre Pharmaceuticals Inc.
CCR5 mAb Phase I clinical trials HIV infection Viral infections Human Genome
Sciences Inc.
Ceftaroline Phase III clinical trials Complicated skin and skin Bacterial infections Forest Laboratories Inc.
structure infection
Ceftaroline Phase III clinical trials Community-acquired Bacterial infections Forest Laboratories Inc.
pneumonia
CEM-101 Phase I clinical trials Community-acquired Bacterial infections Cempra Pharmaceuticals Inc.
pneumonia
Cethromycin Awaiting approval Community-acquired Bacterial infections Advanced Life Sciences Inc.
pneumonia
Cetraxal Otic Awaiting approval External otitis Bacterial infections Laboratorios Salvat SA
Cipro Inhaler Phase II clinical trials Lung infection Bacterial infections Bayer HealthCare
Pharmaceuticals Inc.,
Nektar Therapeutics
Civacir Phase II clinical trials Hepatitis C Viral infections Biotest Pharmaceuticals
Corp., Kedrion SpA
Clevudine Phase III clinical trials Hepatitis B Viral infections Pharmasset Inc.
Coartem Awaiting approval Malaria Anthelmintic Novartis
Collatamp G Phase III clinical trials Surgical site infections Bacterial infections Innocoll Inc.
CS-8958 Phase I clinical trials Influenza Viral infections Daiichi Sankyo Inc., Biota Inc.
Cubicin Phase II clinical trials Osteomyelitis Bacterial infections Cubist Pharmaceuticals Inc.
Cubicin Phase I clinical trials Bacterial infection Bacterial infections Cubist Pharmaceuticals Inc.
CytoFab Phase II clinical trials Sepsis Bacterial infections AstraZeneca
Pharmaceuticals LP
Cytolin Phase II clinical trials HIV/AIDS Viral infections Cytodyn Inc.
Dalbavancin Phase III clinical trials Skin and skin structure Bacterial infections Pfizer Inc.
infections
DermaVir Patch Phase II clinical trials HIV infection Viral infections Genetic Immunity LLC
Doribax Awaiting approval Nosocomial pneumonia Bacterial infections Ortho-McNeil
Pharmaceutical Inc.
DP6-001 Phase I clinical trials HIV infection Viral infections CytRx Corp.
E1224 Phase I clinical trials Fungal infections Fungal infections Eisai Inc.
E5564 Phase III clinical trials Sepsis Bacterial infections Eisai Inc.
EcoNail Phase II clinical trials Onychomycosis Fungal infections MacroChem Corp.
EDP-322 Phase I clinical trials Methicillin-resistant Bacterial infections Enanta Pharmaceuticals Inc.
Staphylococcus aureus
infection
EDP-322 Phase I clinical trials Hospital-acquired infection Bacterial infections Enanta Pharmaceuticals Inc.
eiRNA Phase I clinical trials Hepatitis B Viral infections Nucleonics Inc.
Elvitegravir Phase III clinical trials HIV infection Viral infections Gilead Sciences Inc.
Elvucitabine Phase II clinical trials HIV infection Viral infections Achillion Pharmaceuticals Inc.
EP1090 Phase I clinical trials HIV infection Viral infections Pharmexa-Epimmune Inc.
EP1233 and MVA-BN Phase I clinical trials HIV infection Viral infections Pharmexa-Epimmune Inc.
Polytope Combination
EPB-348 Phase II clinical trials Herpes zoster Viral infections Epiphany Biosciences Inc.
EPB-348 Phase II clinical trials Infectious diseases Viral infections Epiphany Biosciences Inc.
Eraxis/Vfend Combination Phase III clinical trials Aspergillosis Fungal infections Pfizer Inc.
Erdosteine Phase II clinical trials Chronic bronchitis Bacterial infections Adams Respiratory
Therapeutics Inc.
Faropenem Oral Liquid Phase II clinical trials Acute otitis media Bacterial infections Replidyne Inc.
47
Developer/partner
developer
Ferroquine Phase II clinical trials Malaria Anthelmintic Sanofi-Aventis
FV-100 Phase I clinical trials Herpes zoster Viral infections FermaVir Pharmaceuticals
Inc.
GI-5005 Phase II clinical trials Hepatitis C Viral infections GlobeImmune Inc.
GNI-102 Phase I clinical trials Hepatitis B Viral infections GENimmune NV
GS 9131 Phase I clinical trials HIV/AIDS Viral infections Gilead Sciences Inc.
GS 9190 Phase I clinical trials Hepatitis C Viral infections Gilead Sciences Inc.
GS 9191 Phase I clinical trials Human papillomavirus Viral infections Gilead Sciences Inc.
infection
GS 9350 Phase I clinical trials HIV/AIDS Viral infections Gilead Sciences Inc.
HCV-796 Phase II clinical trials Hepatitis C Viral infections ViroPharma Inc.,
HGTV43 Phase I/II clinical trials HIV infection Viral infections Enzo Biochem Inc.
HIV Attachment Inhibitor Phase I clinical trials HIV/AIDS Viral infections Bristol-Myers Squibb Co.
HIV Integrase Inhibitor Phase I clinical trials HIV/AIDS Viral infections Bristol-Myers Squibb Co.
Human Lactoferrin Phase I clinical trials Infections Viral infections Pharming Group NV,
Gem Pharmaceuticals Inc.
Hyphanox Phase III clinical trials Onychomycosis Fungal infections Stiefel Laboratories Inc.
HyVac4 Phase I clinical trials Tuberculosis Bacterial infections The Aeras Global TB Vaccine
Foundation,
Statens Serum Institut
Iclaprim Awaiting approval Complicated skin and skin Bacterial infections Arpida Ltd.
structure infection
Iclaprim Phase II clinical trials Hospital-acquired pneumonia Bacterial infections Arpida Ltd.
Iclaprim Phase II clinical trials Ventilator-associated Bacterial infections Arpida Ltd.
pneumonia
IDX184 Phase I clinical trials Hepatitis C Viral infections Idenix Pharmaceuticals Inc.
IDX899 Phase I/II clinical trials HIV infection Viral infections Idenix Pharmaceuticals Inc.
Immunitin Phase II clinical trials HIV infection Viral infections Hollis-Eden
IMO-2125 Phase I clinical trials Hepatitis C Viral infections Idera Pharmaceuticals Inc.
INCB15050 Phase I clinical trials HIV infection Viral infections Incyte Corp.
INCB9471 Phase II clinical trials HIV infection Viral infections Incyte Corp.
Interleukin-7 Phase I/II clinical trials HIV infection Viral infections Cytheris Inc.
IVR101 Phase II clinical trials Onychomycosis Fungal infections Ivrea Pharmaceuticals Inc.
IVR102 Phase II clinical trials Onychomycosis Fungal infections Ivrea Pharmaceuticals Inc.
JA-001 Phase II clinical trials Herpes zoster Viral infections Janus Pharmaceuticals Inc.,
aRigen Inc.
KB001 Phase I/II clinical trials Pseudomonas aeruginosa Bacterial infections KaloBios Pharmaceuticals Inc.
infections
Keflex PULSYS Phase III clinical trials Bacterial infection Bacterial infections MiddleBrook
KP-1461 Phase II clinical trials HIV infection Viral infections Koronis Pharmaceuticals Inc.
Lamisil Nail Lacquer Phase III clinical trials Onychomycosis Fungal infections Novartis
LCP-Tacro Phase II clinical trials Hepatitis Viral infections LifeCycle Pharma AS
Lipsovir Awaiting approval Labial herpes Viral infections Medivir AB
Locteron Phase II clinical trials Hepatitis C Viral infections Biolex Therapeutics Inc.
Loramyc Phase III clinical trials Oropharyngeal candidiasis Fungal infections BioAlliance Pharma
Low Dose Oral Phase II clinical trials Oral warts Viral infections Amarillo Biosciences Inc.
Interferon-alpha
Maraviroc Phase III clinical trials HIV infection Viral infections Pfizer Inc.
48
Developer/partner
developer
MDX-066/MDX-1388 Phase II clinical trials Clostridium difficile-associated Bacterial infections Medarex Inc., Massachusetts
Combination diarrhea Biologic Laboratories
MDX-1106 Phase I clinical trials Hepatitis C Viral infections Medarex Inc.,
Ono Pharma USA Inc.
ME1036 Phase I clinical trials Bacterial infections Bacterial infections Forest Laboratories Inc.
Microcyn Phase II clinical trials Diabetic foot infections Bacterial infections Oculus Innovative
Sciences Inc.
Miglustat Phase II clinical trials Hepatitis C Viral infections United Therapeutics Corp.
MK-2764 Phase II clinical trials Infectious diseases Bacterial infections Paratek Pharmaceuticals Inc.,
Merck & Co.
MK-3281 Phase I clinical trials Infectious diseases Bacterial infections Merck & Co.
MK-8122 Phase I clinical trials HIV infection Viral infections Merck & Co.
Moxifloxacin/ Phase III clinical trials Ear infections Bacterial infections Alcon Laboratories Inc.
Dexamethasone Otic
Combination
MVA-BN HIV Phase I/II clinical trials HIV infection Viral infections Bavarian Nordic AS
MVA-HCV Phase I clinical trials Hepatitis C Viral infections Transgene Inc.
MX-3253 Phase II clinical trials Hepatitis C Viral infections Migenix Inc.
Mycograb Phase III clinical trials Invasive candidiasis Fungal infections Novartis
NA808 Phase I clinical trials Hepatitis C Viral infections Chugai Pharmaceutical Co.
Nabi-HB Intravenous Awaiting approval Infections Viral infections Biotest Pharmaceuticals Corp.
NB-001 Phase II clinical trials Herpes labialis Viral infections NanoBio Corp.
NB-002 Phase II clinical trials Onychomycosis Fungal infections NanoBio Corp.
Nemonoxacin Phase II clinical trials Bacterial infection Bacterial infections TaiGen Biotechnology Co.
Nemonoxacin Phase II clinical trials Diabetic foot infections Bacterial infections TaiGen Biotechnology Co.
NIM811 Phase II clinical trials Hepatitis C Viral infections Novartis
NKTR-024 Phase I clinical trials Aspergillosis Fungal infections Nektar Therapeutics
NKTR-061 Phase II clinical trials Pneumonia Bacterial infections Nektar Therapeutics,
Bayer HealthCare
NM100060 Phase III clinical trials Onychomycosis Fungal infections Novartis
NOV-205 Phase I clinical trials Chronic hepatitis C Viral infections Novelos Therapeutics Inc.
Noxafil Awaiting approval Fungal infections Fungal infections Schering-Plough Corp.
Noxafil I.V. Phase II clinical trials Fungal infections Fungal infections Schering-Plough Corp.
NUC B1000 Phase I clinical trials Hepatitis B Viral infections Nucleonics Inc.
NVC-422 Phase II clinical trials Respiratory infection Bacterial infections NovaBay
NVC-422 Phase I clinical trials Catheter-related infection Bacterial infections NovaBay
NXL103 Phase II clinical trials Community-acquired Bacterial infections Novexel SA
infection
NXL201 Phase I clinical trials Fungal infections Fungal infections Novexel SA
Oftaquix Phase II clinical trials Infectious keratitis Bacterial infections Santen Inc.
Omega Interferon Phase II clinical trials Chronic hepatitis C Viral infections Intarcia Therapeutics Inc.
Omigard Phase III clinical trials Catheter-related infection Bacterial infections Cadence
OPT-80 Phase III clinical trials Clostridium difficile-associated Bacterial infections Optimer Pharmaceuticals Inc.
diarrhea
49
Developer/partner
developer
Oral Belerofon Phase I clinical trials Hepatitis C Viral infections Nautilus Biotech
Oral Iclaprim Phase I clinical trials Severe infections Bacterial infections Arpida Ltd.
Oral Iclaprim Phase II clinical trials Skin and skin structure Bacterial infections Arpida Ltd.
infections
Oritavancin Awaiting approval Skin and skin structure Bacterial infections Targanta Therapeutics
infections
P-113 Rinse Phase II clinical trials Oral candidiasis Fungal infections Pacgen
Biopharmaceuticals Corp.
PA-1050040 Phase I clinical trials HIV infection Viral infections Panacos
PA-824 Phase II clinical trials Tuberculosis Bacterial infections The Global Alliance for TB
Drug Development
PEG-Interferon Lambda Phase I clinical trials Hepatitis C Viral infections ZymoGenetics Inc.
Pennvax-B Phase I clinical trials HIV infection Viral infections VGX Pharmaceuticals
Peramivir I.M. Phase II clinical trials Influenza Viral infections BioCryst Pharmaceuticals Inc.
Peramivir I.V. Phase II clinical trials Influenza Viral infections BioCryst Pharmaceuticals Inc.
Pexiganan Phase III clinical trials Diabetic foot infections Bacterial infections MacroChem Corp.
PF-232798 Phase II clinical trials HIV infection Viral infections Pfizer Inc.
PF-4064900 Phase I clinical trials Bacterial infections Bacterial infections Pfizer Inc.
PF-4194471 Phase I clinical trials Hepatitis C Viral infections Pfizer Inc.
PF-4522625 Phase I clinical trials Seasonal influenza Viral infections Pfizer Inc.
PF-4878691 Phase I clinical trials Hepatitis C Viral infections Pfizer Inc.
PF-868554 Phase II clinical trials Hepatitis C Viral infections Pfizer Inc.
Pictovir Phase II clinical trials HIV infection Viral infections VGX Pharmaceuticals
Pleconaril Phase II clinical trials Viral infection Viral infections Sanofi-Aventis
Pradefovir Phase II clinical trials Hepatitis B Viral infections Metabasis Therapeutics Inc.
PRO 140 Phase II clinical trials HIV infection Viral infections Progenics
PRO 2000 Phase III clinical trials HIV infection and other Viral infections Indevus Pharmaceuticals Inc.
sexually transmitted diseases
Promacta Phase III clinical trials Hepatitis C Viral infections GlaxoSmithKline Inc.
PZ-601 Phase II clinical trials Bacterial infection Bacterial infections Novartis
PZ-601 Phase II clinical trials Complicated skin and skin Bacterial infections Novartis
structure infection Pharmaceuticals Corp.
R1626 Phase II clinical trials Hepatitis C Viral infections Hoffmann-La Roche Inc.
R7128 Phase I clinical trials Hepatitis C Viral infections Hoffmann-La Roche Inc.
R7227 Phase I clinical trials Hepatitis C Viral infections InterMune Inc.,
R7227 Phase I clinical trials Chronic hepatitis C Viral infections InterMune Inc.,
Racivir Phase II clinical trials HIV infection Viral infections Pharmasset Inc.
Ramoplanin Phase II clinical trials Clostridium difficile-associated Bacterial infections Oscient
disease Pharmaceuticals Corp.
RDEA806 Phase II clinical trials HIV infection Viral infections Ardea Biosciences Inc.
REP8839 Phase I clinical trials Staphylococcus aureus Bacterial infections Replidyne Inc.
infection
REP8839 Phase I clinical trials Wounds Bacterial infections Replidyne Inc.
rF1V Phase II clinical trials Plague bacterium Yersinia Bacterial infections DynPort Vaccine
pestis infection Company LLC
rhMBL Phase II clinical trials Infections Bacterial infections Enzon Pharmaceuticals Inc.
Rifamycin SV MMX Phase II clinical trials Bacterial infection Bacterial infections Cosmo Pharmaceuticals
RPI-MN Phase I clinical trials HIV infection Viral infections Receptopharm Inc.
50
Developer/partner
developer
RX-1741 Phase II clinical trials Methicillin-resistant Bacterial infections Rib-X Pharmaceuticals Inc.
infection
RX-1741 Phase II clinical trials Community-acquired Bacterial infections Rib-X Pharmaceuticals Inc.
pneumonia
RX-1741 Phase II clinical trials Skin and skin structure Bacterial infections Rib-X Pharmaceuticals Inc.
infections
RX-3341 Phase II clinical trials Methicillin-resistant Bacterial infections Rib-X Pharmaceuticals Inc.
infection
RX-3341 Phase II clinical trials Complicated skin and skin Bacterial infections Rib-X Pharmaceuticals Inc.
structure infection
S-247303 Phase II clinical trials HIV infection Viral infections Shionogi USA Inc.,
SAR97276 Phase I clinical trials Malaria Anthelmintic Sanofi-Aventis
SCV-07 Phase II clinical trials Viral infectious diseases Viral infections SciClone
Shigamabs Phase I clinical trials Shigatoxin-producing E. coli Bacterial infections Thallion Pharmaceuticals Inc.
bacterial infections
SinuNase Phase III clinical trials Sinusitis Bacterial infections Accentia
SoloVir ETS Phase II clinical trials Herpes labialis Viral infections Transport
SP01A Phase II clinical trials HIV infection Viral infections Pharmaplaz Ltd.
SPI-256 Phase I clinical trials HIV infection Viral infections Sequoia Pharmaceuticals Inc.
SPRC-AB01 Phase II clinical trials Chronic rhinosinusitis Bacterial infections Naryx Pharma Inc.
SQ109 Phase I clinical trials Tuberculosis Bacterial infections Sequella Inc.
SUBA-Itraconazole Phase I clinical trials Fungal infections Fungal infections HalcyGen
Pharmaceuticals Ltd.
Sulopenem I.V. Phase I clinical trials Bacterial infection Bacterial infections Pfizer Inc.
Sulopenem Oral Phase I clinical trials Bacterial infection Bacterial infections Pfizer Inc.
T-705 Phase I clinical trials Influenza Viral infections Toyama USA Inc.
Tafenoquine Phase II clinical trials Malaria Anthelmintic GlaxoSmithKline Inc.
TAK-242 Phase III clinical trials Sepsis Bacterial infections Takeda Pharmaceuticals
North America Inc.
Talactoferrin Phase II clinical trials Sepsis Bacterial infections Agennix Inc.
TBM100 Phase III clinical trials Pseudomonas aeruginosa Bacterial infections Novartis Pharmaceuticals
infections Corp., Nektar Therapeutics
TBR-220 Phase I clinical trials HIV infection Viral infections Tobira Therapeutics Inc.
TBR-652 Phase I clinical trials HIV infection Viral infections Tobira Therapeutics Inc.
TD-1792 Phase II clinical trials Bacterial infection Bacterial infections Theravance Inc.
Telaprevir Phase III clinical trials Hepatitis C Viral infections Vertex Pharmaceuticals Inc.
Telavancin Phase III clinical trials Hospital-acquired pneumonia Bacterial infections Astellas Pharma US Inc.
Telavancin Awaiting approval Complicated skin and skin Bacterial infections Astellas Pharma US Inc.
structure infection
Tesamorelin Phase III clinical trials HIV-related lipodystrophy Viral infections Theratechnologies Inc.
TFP561 Phase III clinical trials Community-acquired Bacterial infections Novartis
pneumonia Pharmaceuticals Corp.
TMC278 Phase III clinical trials HIV infection Viral infections Tibotec Therapeutics
Topical Antifungal Phase II clinical trials Onychomycosis Fungal infections Schering-Plough Corp.
51
Developer/partner
developer
TR-701 Phase II clinical trials Complicated skin and skin Bacterial infections Trius Therapeutics Inc.
structure infection
TRI-1144 Phase I clinical trials HIV/AIDS Viral infections Trimeris Inc.
Tygacil Awaiting approval Community-acquired Bacterial infections Wyeth Pharmaceuticals
pneumonia
Tygacil Phase II clinical trials Hospital-acquired pneumonia Bacterial infections Wyeth Pharmaceuticals
Tygacil Phase III clinical trials Diabetic foot infections Bacterial infections Wyeth Pharmaceuticals
UK-453061 Phase II clinical trials HIV infection Viral infections Pfizer Inc.
URG301 Phase I clinical trials Urethritis Bacterial infections Urigen Pharmaceuticals Inc.
V419 Phase II clinical trials Infectious diseases Bacterial infections Merck & Co.
Vacc-4x Phase II clinical trials HIV infection Viral infections Bionor Immuno AS
Valcyte Phase III clinical trials Cytomegalovirus retinitis Viral infections Hoffmann-La Roche Inc.
Valortim Phase I clinical trials Anthrax infection Bacterial infections Medarex Inc.,
PharmAthene US Corp.
VGX-410 Phase II clinical trials Hepatitis C Viral infections VGX Pharmaceuticals
Vicriviroc Phase III clinical trials HIV infection Viral infections Schering-Plough Corp.
Viramidine Phase II clinical trials Chronic hepatitis C Viral infections Valeant Pharmaceuticals
International
VivaGel Phase I clinical trials HIV infection Viral infections Starpharma Ltd.
VivaGel Phase I clinical trials Genital herpes Viral infections Starpharma Ltd.
Vivecon Phase I clinical trials HIV infection Viral infections Myriad Pharmaceuticals Inc.
VRX496 Phase II clinical trials HIV/AIDS Viral infections Virxsys Corp.
VX-500 Phase I clinical trials Hepatitis C Viral infections Vertex Pharmaceuticals Inc.
WNIG Phase I/II clinical trials West Nile virus infection Viral infections Omrix
XTL-6865 Phase I clinical trials Hepatitis C Viral infections XTL Biopharmaceuticals Ltd.
XTL-6865 Phase I clinical trials Hepatitis C Viral infections XTL Biopharmaceuticals Inc.
Zadaxin Phase III clinical trials Hepatitis C Viral infections SciClone
Zeftera Awaiting approval Complicated skin and skin Bacterial infections Basilea Pharmaceutica
structure infection Ltd., Johnson & Johnson
Development
Zeftera Phase III clinical trials Nosocomial pneumonia Bacterial infections Basilea Pharmaceutica
Ltd., Johnson & Johnson
Development
Zeftera Phase III clinical trials Hospital community-acquired Bacterial infections Basilea Pharmaceutica
pneumonia Ltd., Johnson & Johnson
Development
ZFP Therapeutic Phase I clinical trials HIV infection Viral infections Sangamo Biosciences Inc.
Zithromax/Chloroquine Phase III clinical trials Malaria Anthelmintic Pfizer Inc.
Combination
52
TOP 15 THERAPEUTIC GROUPS: CARDIOVASCULAR
Developer/partner
developer
256073 Phase I clinical trials Dyslipidemia Cholesterol reducers GlaxoSmithKline Inc.
681323 Phase II clinical trials Atherosclerosis Cholesterol reducers GlaxoSmithKline Inc.
6R-BH4 Phase II clinical trials Pulmonary arterial Cardiovascular drugs BioMarin Pharmaceutical Inc.,
hypertension EMD Serono Inc.
6R-BH4 Phase II clinical trials Peripheral arterial disease Cardiovascular drugs BioMarin Pharmaceutical Inc.,
EMD Serono Inc.
813893 Phase I clinical trials Stroke Stroke treatments GlaxoSmithKline Inc.
856553 Phase II clinical trials Atherosclerosis Cardiovascular drugs GlaxoSmithKline Inc.
ABT-143 Phase III clinical trials Dyslipidemia Cholesterol reducers Abbott Laboratories
Acadesine Phase III clinical trials Ischemia-reperfusion injury Cardiovascular drugs Schering-Plough Corp.
Acomplia Phase III clinical trials Dyslipidemia Cholesterol reducers Sanofi-Aventis
Acomplia Phase III clinical trials Atherosclerotic disease Cardiovascular drugs Sanofi-Aventis
Actelion -1 Phase III clinical trials Pulmonary arterial Cardiovascular drugs Actelion Pharmaceuticals
hypertension US Inc.
Actos Phase III clinical trials Atherosclerosis Cardiovascular drugs Takeda Pharmaceuticals
North America Inc.,
Eli Lilly and Co.
Adenosine A1 Agonist Phase II clinical trials Stable angina Cardiovascular drugs Bayer HealthCare
Adenosine A1 Agonist Phase II clinical trials Atrial fibrillation Cardiovascular drugs Bayer HealthCare
Adentri I.V. Phase III clinical trials Acute decompensated Cardiovascular drugs Biogen Idec Inc.
heart failure
Adentri Oral Phase II clinical trials Chronic heart failure Cardiovascular drugs Biogen Idec Inc.
ADX415 Phase II clinical trials Hypertension Cardiovascular drugs Sciele Pharma Inc., Addrenex
AEGR-733 Phase III clinical trials Hypercholesterolemia Cholesterol reducers Aegerion
Alagebrium Phase II clinical trials Heart failure Cardiovascular drugs Synvista Therapeutics Inc.
Aldesort Phase I/II clinical trials Critical limb ischemia Peripheral arterial occlusive Aldagen Inc.
disease therapy
Allogeneic Aduls Stem Cell Phase II clinical trials Heart attack Cardiovascular drugs Angioblast Systems Inc.
Allogeneic Aduls Stem Cell Phase II clinical trials Congestive heart failure Cardiovascular drugs Angioblast Systems Inc.
AMR-001 Phase I clinical trials Acute myocardial infarction Cardiovascular drugs Amorcyte Inc.,
Progenitor Cell Therapy LLC
AMR101 Phase III clinical trials Hypertriglyceridemia Cholesterol reducers Amarin Corporation Plc.
Anginera Phase I clinical trials Coronary artery disease Cardiovascular drugs Theregen Corp.
Angiomax Awaiting approval Acute coronary syndrome Cardiovascular drugs The Medicines Co.
Angiotensin Phase II clinical trials Hypertension Cardiovascular drugs Protherics Inc.
Immunotherapeutic
Anti-oxLDL Phase I clinical trials Cardiovascular events Cardiovascular drugs Genentech Inc.
Apixaban Phase III clinical trials Atrial fibrillation Cardiovascular drugs Bristol-Myers Squibb Co.,
Pfizer Inc.
Apixaban Phase II clinical trials Acute coronary syndrome Cardiovascular drugs Bristol-Myers Squibb Co.,
Pfizer Inc.
Aquilda Awaiting approval Hyponatremia Cardiovascular drugs Sanofi-Aventis
AR9281 Phase I clinical trials Hypertension Cardiovascular drugs Arete Therapeutics Inc.
Aranesp Phase III clinical trials Cardiovascular disease Cardiovascular drugs Amgen Inc.
ARC1779 Phase II clinical trials Acute coronary syndrome Cardiovascular drugs Archemix Corp.
Arixtra Awaiting approval Acute coronary syndrome Cardiovascular drugs GlaxoSmithKline Inc.
Aspirin I.V. Phase III clinical trials Acute coronary syndrome Cardiovascular drugs Bayer HealthCare
Ataciguat Phase II clinical trials Peripheral arterial disease Cardiovascular drugs Sanofi-Aventis
53
Developer/partner
developer
ATI-2042 Phase II clinical trials Atrial fibrillation Cardiovascular drugs Aryx Therapeutics Inc.
Avandia Phase III clinical trials Atherosclerosis Cholesterol reducers GlaxoSmithKline Inc.
AVE0847 Phase II clinical trials Mixed dyslipidemia Cholesterol reducers Sanofi-Aventis
AVE3085 Phase I clinical trials Congestive heart failure Cardiovascular drugs Sanofi-Aventis
AVE5530 Phase III clinical trials Hypercholesterolemia Cholesterol reducers Sanofi-Aventis
AVE8134 Phase II clinical trials Mixed dyslipidemia Cholesterol reducers Sanofi-Aventis
AVE8134 Phase II clinical trials Congestive heart failure Cardiovascular drugs Sanofi-Aventis
Aviptadil Phase II clinical trials Pulmonary arterial Cardiovascular drugs Biogen Idec Inc.
hypertension
AZD1305 Phase II clinical trials Arrhythmia Cardiovascular drugs AstraZeneca
Pharmaceuticals LP
Azor Awaiting approval High blood pressure Cardiovascular drugs Daiichi Sankyo Inc.
Beraprost-MR Phase III clinical trials Pulmonary arterial Cardiovascular drugs United Therapeutics Corp.
hypertension
Betaprost SR Phase I clinical trials Pulmonary arterial Cardiovascular drugs United Therapeutics Corp.
hypertension
Betaprost SR Phase I clinical trials Peripheral vascular disease Cardiovascular drugs United Therapeutics Corp.
Betrixaban Phase II clinical trials Stroke prevention Stroke treatments Portola Pharmaceuticals Inc.
Betrixaban Phase II clinical trials Myocardial infarction Cardiovascular drugs Portola Pharmaceuticals Inc.
and stroke
BL-1040 Phase I/II clinical trials Acute myocardial infarction Cardiovascular drugs BioLineRx Ltd.
BT16 Phase I clinical trials Dyslipidemia Cholesterol reducers Quark Pharmaceuticals Inc.
BVI-007 Phase I clinical trials Cardiovascular events Cardiovascular drugs BioVascular Inc.
Bystolic Phase III clinical trials Congestive heart failure Cardiovascular drugs Forest Laboratories Inc.
CCX140 Phase I clinical trials Vascular disease Cardiovascular drugs ChemoCentryx Inc.
CD-NP Phase II clinical trials Acute decompensated Cardiovascular drugs Nile Therapeutics Inc.
heart failure
Celacade Phase III clinical trials Chronic heart failure Cardiovascular drugs Vasogen Inc.
Celivarone Phase II clinical trials Atrial fibrillation Cardiovascular drugs Sanofi-Aventis
CER-002 Phase I clinical trials Cardiovascular disease Cardiovascular drugs Cerenis Therapeutics Inc.
Cerebril Phase II clinical trials Hemorrhagic stroke Stroke treatments Bellus Health Inc.
Cialis Phase III clinical trials Pulmonary arterial Cardiovascular drugs Eli Lilly and Co.
hypertension
CK-1827452 Phase II clinical trials Heart failure Cardiovascular drugs Cytokinetics Inc.
CloniBID Awaiting approval Hypertension Cardiovascular drugs Sciele Pharma Inc.
Coreg CR Plus ACE Inhibitor Phase III clinical trials Hypertension Cardiovascular drugs GlaxoSmithKline Inc.
Coroxane Phase II clinical trials Coronary artery restenosis Cardiovascular drugs Abraxis BioScience Inc.
Coroxane Phase II clinical trials Peripheral arterial restenosis Cardiovascular drugs Abraxis BioScience Inc.
CP-800569 Phase I clinical trials Atherosclerosis Cardiovascular drugs Pfizer Inc.
Crestor Phase III clinical trials C-reactive protein outcomes Cardiovascular drugs AstraZeneca
Pharmaceuticals LP
Crestor/TriLipix Phase III clinical trials Dyslipidemia Cholesterol reducers Abbott Laboratories,
Combination AstraZeneca
Pharmaceuticals LP
CS-8080 Phase I clinical trials Arteriosclerosis Cardiovascular drugs Daiichi Sankyo Inc.
CS-8635 Phase III clinical trials Hypertension Cardiovascular drugs Daiichi Sankyo Inc.
CVBT-141A Phase II clinical trials No-option heart patients with Cardiovascular drugs CardioVascular
coronary heart disease BioTherapeutics Inc.
CVBT-141C Phase I clinical trials Peripheral vascular disease Cardiovascular drugs CardioVascular
BioTherapeutics Inc.
CVBT-141H Phase II clinical trials Coronary heart disease Cardiovascular drugs CardioVascular
BioTherapeutics Inc.
54
Developer/partner
developer
Daglutril Phase II clinical trials Hypertension Cardiovascular drugs Solvay Pharmaceuticals Inc.
Daglutril Phase II clinical trials Congestive heart failure Cardiovascular drugs Solvay Pharmaceuticals Inc.
Darapladib Phase II/III clinical trials Atherosclerosis Cardiovascular drugs GlaxoSmithKline Inc.
Darusentan Phase III clinical trials Resistant hypertension Cardiovascular drugs Gilead Sciences Inc.
DB-772d Phase I clinical trials Cardiovascular disease Cardiovascular drugs Daiichi Sankyo Inc.
Desmoteplase Phase III clinical trials Acute ischemic stroke Stroke treatments H. Lundbeck AS
DG051 Phase II clinical trials Heart attack Cardiovascular drugs deCode Genetics Inc.
Digoxin Immune Fab Phase II clinical trials Pre-eclampsia Cardiovascular drugs Protherics Inc.
DITPA Phase II clinical trials Elevated cholesterol Cholesterol reducers Titan Pharmaceuticals Inc.
reduction
Droxidopa Phase III clinical trials Neurogenic orthostatic Cardiovascular drugs Chelsea Therapeutics Inc.
hypotension
Droxidopa Phase II clinical trials Intradialytic hypotension Cardiovascular drugs Chelsea Therapeutics Inc.
DU-176b Phase II clinical trials Non-valvular atrial fibrillation Cardiovascular drugs Daiichi Sankyo Inc.
Dual FIIa/Xa Inhibitor Phase I clinical trials Acute coronary syndrome Cardiovascular drugs Bayer HealthCare
E5555 Phase II clinical trials Acute coronary syndrome Cardiovascular drugs Eisai Inc.
E5555 Phase II clinical trials Atherothrombotic disease Cardiovascular drugs Eisai Inc.
Ecallantide Phase II clinical trials Blood-loss prevention in Cardiovascular drugs Dyax Corp.,
coronary artery bypass graft Cubist Pharmaceuticals Inc.
surgery
Ecallantide Phase I/II clinical trials Cardiac surgery Cardiovascular drugs Dyax Corp., Cubist
Effient Awaiting approval Acute coronary syndrome Cardiovascular drugs Daiichi Sankyo Inc.,
Eli Lilly and Co.
Elastase Inhibitor Phase I clinical trials Pulmonary hypertension Cardiovascular drugs Bayer HealthCare
EP42675 Phase I clinical trials Cardiovascular disease Cardiovascular drugs Endotis Pharma SA
FM-VP4 Phase II clinical trials Elevated cholesterol Cholesterol reducers Forbes Medi-Tech Inc.
reduction
GAP-134 I.V. Phase I clinical trials Atrial fibrillation Cardiovascular drugs Wyeth Pharmaceuticals
GED-aPC Phase I clinical trials Cardiogenic shock Cardiovascular drugs Cardiome Pharma Corp.
Gencaro Awaiting approval Chronic heart failure Cardiovascular drugs ARCA Biopharma Inc.
Gene Therapy Phase II clinical trials Peripheral arterial disease Cardiovascular drugs Genzyme Corp.
Generx Phase III clinical trials Myocardial ischemia Cardiovascular drugs Cardium Therapeutics Inc.
Generx Phase III clinical trials Stable angina pectoris Cardiovascular drugs Cardium Therapeutics Inc.
GFT505 Phase II clinical trials Dyslipidemia Cholesterol reducers Genfit Corp.
Hemopure Phase II clinical trials Post-cardiovascular bypass Cardiovascular drugs Biopure Corp.
surgery
Hemospan Phase II clinical trials Critical limb ischemia Peripheral arterial occlusive Sangart Inc.
disease therapy
Hemoximer Phase III clinical trials Distributive shock Cardiovascular drugs Curacyte AG
HGF DNA Therapy Phase II clinical trials Peripheral arterial disease Cardiovascular drugs AnGes MG Inc.
HGF DNA Therapy Phase I clinical trials Coronary artery disease Cardiovascular drugs AnGes MG Inc.
Icodextrin Phase II clinical trials Congestive heart failure Cardiovascular drugs Baxter Healthcare Corp.
Idrabiotaparinux Phase III clinical trials Atrial fibrillation Cardiovascular drugs Sanofi-Aventis
Idraparinux Phase III clinical trials Atrial fibrillation Cardiovascular drugs Sanofi-Aventis
IK-1001 Phase I clinical trials Ischemia Stroke treatments Ikaria Holdings Inc.
Inhaled Treprostinil Awaiting approval Pulmonary arterial Cardiovascular drugs United Therapeutics Corp.
hypertension
Inhaled Treprostinil with Phase I clinical trials Pulmonary arterial Cardiovascular drugs United Therapeutics Corp.
AERx Essence hypertension
55
Developer/partner
developer
INO-1001 Phase II clinical trials Cardiac injury Cardiovascular drugs Inotek Pharmaceuticals Corp.
Integrilin Phase III clinical trials Acute coronary syndrome Cardiovascular drugs Schering-Plough Corp.
Iroxanadine Phase II clinical trials Atherosclerosis Cardiovascular drugs CytRx Corp.
Isis 353512 Phase I clinical trials Coronary artery disease Cardiovascular drugs Isis Pharmaceuticals Inc.
KAI-1455 Phase I clinical trials Ischemia Cardiovascular drugs KAI Pharmaceuticals Inc.
KAI-9803 Phase I/II clinical trials Heart attack Cardiovascular drugs Bristol-Myers Squibb Co.
Kynapid Awaiting approval Acute atrial fibrillation Cardiovascular drugs Cardiome Pharma Corp.,
Astellas Pharma US Inc.
Lantus Phase III clinical trials Cardiovascular disease Cardiovascular drugs Sanofi-Aventis
LCI699 Phase I clinical trials Hypertension Cardiovascular drugs Novartis
LCP-AtorFen Phase II clinical trials Mixed dyslipidemia Cholesterol reducers LifeCycle Pharma AS
LCZ696 Phase II clinical trials Hypertension Cardiovascular drugs Novartis
LibiGel Phase III clinical trials Myocardial infarction and Stroke treatments BioSante Pharmaceuticals Inc.
stroke
Lixivaptan Phase III clinical trials Hyponatremia Cardiovascular drugs Cardiokine Inc.,
Biogen Idec Inc.
Lotrel Phase III clinical trials High-risk hypertension Cardiovascular drugs Novartis
M118 Phase II clinical trials Acute coronary syndrome Cardiovascular drugs Momenta
MB07811 Phase I clinical trials Hyperlipidemia Cholesterol reducers Metabasis Therapeutics Inc.
MBX-8025 Phase II clinical trials Dyslipidemia Cholesterol reducers Metabolex Inc.
MC-1 Phase III clinical trials Coronary artery bypass graft Cardiovascular drugs Medicure Inc.
MC-4232 Phase II clinical trials Diabetic hypertension Cardiovascular drugs Medicure Inc.
MCC-135 Phase II clinical trials Myocardial infarction Cardiovascular drugs Mitsubishi Tanabe
Pharma Corp.
Mipomersen Phase III clinical trials Heterozygous familial Cholesterol reducers Genzyme Corp.
hypercholesterolemia
MK-0448 Phase I clinical trials Cardiovascular disease Cardiovascular drugs Merck & Co.
MK-0524A Phase III clinical trials Atherosclerosis Cardiovascular drugs Merck & Co.
MK-0524B Phase III clinical trials Atherosclerosis Cardiovascular drugs Merck & Co.
MK-0724 Phase II clinical trials Acute ischemic stroke Stroke treatments Merck & Co.
MK-0859 Phase III clinical trials Atherosclerosis Cardiovascular drugs Merck & Co.
MK-1809 Phase I clinical trials Cardiovascular disease Cardiovascular drugs Merck & Co.
MK-1903 Phase I clinical trials Atherosclerosis Cardiovascular drugs Merck & Co.
MK-6213 Phase II clinical trials Atherosclerosis Cardiovascular drugs Merck & Co.
MK-7418 Phase III clinical trials Congestive heart failure Cardiovascular drugs Merck & Co.
MK-8141 Phase II clinical trials Cardiovascular disease Cardiovascular drugs Merck & Co.
MLN1202 Phase II clinical trials Atherosclerotic cardiovascular Cardiovascular drugs Millennium: The Takeda
disease Oncology Company
MRX-801 Phase I/II clinical trials Ischemic stroke Stroke treatments ImaRx Therapeutics Inc.
MRX-815 Phase I/II clinical trials Stroke Stroke treatments ImaRx Therapeutics Inc.
Multaq Awaiting approval Atrial fibrillation Cardiovascular drugs Sanofi-Aventis
MultiStem Phase I clinical trials Acute myocardial infarction Cardiovascular drugs Angiotech Pharmaceuticals
Inc., Athersys Inc.
MyoCell Phase II/III clinical trials Congestive heart failure Cardiovascular drugs Bioheart Inc.
Neu2000KL Phase I clinical trials Ischemic stroke Stroke treatments Amkor Pharmaceuticals Inc.
NO-antihypertensive Phase I clinical trials Hypertension Cardiovascular drugs Merck & Co.
NV1FGF Phase III clinical trials Critical limb ischemia Cardiovascular drugs Sanofi-Aventis
56
Developer/partner
developer
Oral Modified Release Phase I clinical trials Congestive heart failure Cardiovascular drugs T3 Therapeutics LLC,
Liothyronine Sodium Archimedes Pharma Ltd.
Oral Treprostinil Phase II clinical trials Peripheral vascular disease Cardiovascular drugs United Therapeutics Corp.
Oral Treprostinil Phase III clinical trials Pulmonary arterial Cardiovascular drugs United Therapeutics Corp.
hypertension
Otamixaban Phase II clinical trials Acute coronary syndrome Cardiovascular drugs Sanofi-Aventis
PF-3185043 Phase I clinical trials Atherosclerosis Cardiovascular drugs Pfizer Inc.
PF-489791 Phase I clinical trials Pulmonary hypertension Cardiovascular drugs Pfizer Inc.
PL-3994 Phase I clinical trials Acutely decompensated Cardiovascular drugs Palatin Technologies Inc.
congestive heart failure
PL-3994 Phase II clinical trials Hypertension Cardiovascular drugs Palatin Technologies Inc.
Pravastatin/Fenofibrate Phase III clinical trials Mixed dyslipidemia Cholesterol reducers Sciele Pharma Inc.
Combination
Prochymal Phase II clinical trials Myocardial infarction Cardiovascular drugs Osiris Therapeutics Inc.
Provacel Phase I clinical trials Acute myocardial infarction Cardiovascular drugs Osiris Therapeutics Inc.
PRT060128 Phase II clinical trials Myocardial infarction Cardiovascular drugs Portola Pharmaceuticals Inc.
PRT060128 Phase II clinical trials Stroke Stroke treatments Portola Pharmaceuticals Inc.
PRX-08066 Phase II clinical trials Pulmonary hypertension Cardiovascular drugs Epix Pharmaceuticals Inc.
PS433540 Phase II clinical trials Cardiovascular disease Cardiovascular drugs Pharmacopeia Inc.
PS433540 Phase II clinical trials Hypertension Cardiovascular drugs Pharmacopeia Inc.
Pulzium Awaiting approval Atrial fibrillation Cardiovascular drugs Solvay Pharmaceuticals Inc.
R1512 Phase I clinical trials Peripheral vascular disease Cardiovascular drugs Hoffmann-La Roche Inc.,
Genmab Inc.
R1658 Phase III clinical trials Dyslipidemia Cholesterol reducers Hoffmann-La Roche Inc.
R7232 Phase I clinical trials Dyslipidemia Cholesterol reducers Hoffmann-La Roche Inc.
REG1 Phase II clinical trials Acute coronary syndrome Cardiovascular drugs Regado Biosciences
Relaxin Phase II clinical trials Acute heart failure Cardiovascular drugs Corthera Inc.
Renin Inhibitor Phase II clinical trials Cardiovascular disease Cardiovascular drugs Actelion Pharmaceuticals US
Inc., Merck & Co.
Resten-MP Phase II clinical trials Cardiovascular restenosis Cardiovascular drugs AVI BioPharma Inc.
Resten-NG Phase II clinical trials Cardiovascular restenosis Cardiovascular drugs AVI BioPharma Inc.
RGN-352 Phase I clinical trials Acute myocardial infarction Cardiovascular drugs RegeneRx
Rifalazil Phase II clinical trials Atherosclerosis Cardiovascular drugs ActivBiotics Inc.
Rilapladib Phase I clinical trials Atherosclerosis Cholesterol reducers GlaxoSmithKline Inc.
Rivaroxaban Phase III clinical trials Stroke Stroke treatments Bayer HealthCare
Johnson & Johnson
Development
RVX-208 Phase I/II clinical trials Cardiovascular disease Cardiovascular drugs Resverlogix Corp.
Sensipar Phase III clinical trials Cardiovascular disease Cardiovascular drugs Amgen Inc.
sGC Activator Phase II clinical trials Acute heart failure Cardiovascular drugs Bayer HealthCare
sGC Activator Phase II clinical trials Heart failure Cardiovascular drugs Bayer HealthCare
sGC Activator Phase II clinical trials Pulmonary hypertension Cardiovascular drugs Bayer HealthCare
SLV320 Phase II clinical trials Congestive heart failure Cardiovascular drugs Solvay Pharmaceuticals Inc.
SLx-2101 Phase II clinical trials Pulmonary arterial Cardiovascular drugs Surface Logix Inc.
hypertension
SLx-4090 Phase II clinical trials Dyslipidemia Cholesterol reducers Surface Logix Inc.
57
Developer/partner
developer
Sobetirome Phase I clinical trials Elevated cholesterol Cholesterol reducers QuatRx Pharmaceuticals Co.
reduction
Starlix/Diovan Combination Phase III clinical trials Cardiovascular morbidity and Cardiovascular drugs Novartis Pharmaceuticals
mortality Corp.
TAK-491 Phase III clinical trials Hypertension Cardiovascular drugs Takeda Pharmaceuticals
North America Inc.
TAK-536 Phase II clinical trials Hypertension Cardiovascular drugs Takeda Pharmaceuticals
North America Inc.
Tecadenoson Phase III clinical trials Paroxysmal supraventricular Cardiovascular drugs CV Therapeutics Inc.
tachycardia
Tecadenoson Phase II clinical trials Atrial fibrillation Cardiovascular drugs CV Therapeutics Inc.
Tekturna Fixed-Dose Phase III clinical trials Hypertension Cardiovascular drugs Novartis Pharmaceuticals
Combination Corp.
Thelin Phase II clinical trials Diastolic heart failure Cardiovascular drugs Pfizer Inc.
Tolvaptan Awaiting approval Congestive heart failure Cardiovascular drugs Otsuka Pharmaceutical
Development &
Tolvaptan Awaiting approval Hyponatremia Cardiovascular drugs Otsuka Pharmaceutical
Development &
Tracleer Phase III clinical trials Pulmonary arterial Cardiovascular drugs Actelion Pharmaceuticals
hypertension US Inc.
Trans Sodium Crocetinate Phase I clinical trials Ischemia Cardiovascular drugs Diffusion Pharmaceuticals LLC
Trans Sodium Crocetinate Phase I/II clinical trials Peripheral arterial disease Cardiovascular drugs Diffusion Pharmaceuticals LLC
TRIA-662 Phase II clinical trials Dyslipidemia Cholesterol reducers Cortria Corp.
Tricor/TriLipix Combination Awaiting approval Lipid disorders Cholesterol reducers Abbott Laboratories
TriLipix Awaiting approval Unhealthy lipid level Cholesterol reducers Abbott Laboratories,
Solvay Pharmaceuticals Inc.
Ularitide Phase II clinical trials Acute decompensated Cardiovascular drugs EKR Therapeutics Inc.
heart failure
Urocortin 2 Phase II clinical trials Congestive heart failure Cardiovascular drugs Neurocrine Biosciences Inc.
V10153 Phase II clinical trials Acute ischemic stroke Stroke treatments Vernalis Plc.
Varespladib Phase II clinical trials Coronary atherosclerosis Cardiovascular drugs Anthera Pharmaceuticals Inc.
Varespladib Phase III clinical trials Acute coronary syndrome Cardiovascular drugs Anthera Pharmaceuticals Inc.
Vascana Awaiting approval Raynaud phenomenon Circulatory disorder therapies MediQuest Therapeutics Inc.
disease
Vascular Repair Cell Phase II clinical trials Critical limb ischemia Peripheral arterial occlusive Aastrom Biosciences Inc.
disease therapy
Vernakalant Oral Phase II clinical trials Atrial fibrillation Cardiovascular drugs Cardiome Pharma Corp.
VIA-2291 Phase II clinical trials Cardiovascular risk reduction Cardiovascular drugs VIA Pharmaceuticals Inc.
VIA-2291 Phase II clinical trials Vascular inflammation Cardiovascular drugs VIA Pharmaceuticals Inc.
reduction
Viprinex Phase III clinical trials Acute ischemic stroke Stroke treatments Neurobiological
Technologies Inc.
Viveta Phase III clinical trials Pulmonary arterial Cardiovascular drugs United Therapeutics Corp.
hypertension
VNP489 Phase I clinical trials Hypertension Cardiovascular drugs Novartis
VT-111 Phase II clinical trials Vascular inflammation Cardiovascular drugs Viron Therapeutics Inc.
reduction
Vytorin Phase III clinical trials Acute coronary syndrome Cardiovascular drugs Merck/Schering-Plough
Pharmaceuticals
Vytorin Phase III clinical trials Aortic stenosis Cardiovascular drugs Merck/Schering-Plough
Pharmaceuticals
Zemiva Phase II clinical trials Cardiac ischemia Cardiovascular drugs Molecular Insight
58
Developer/partner
developer
Zetia Awaiting approval Primary hypercholesterolemia Cholesterol reducers Merck/Schering-Plough
Pharmaceuticals
ZFP Therapeutic Phase I clinical trials Peripheral arterial disease Cardiovascular drugs Sangamo Biosciences Inc.
ZFP Therapeutic Phase I clinical trials Critical limb ischemia Peripheral arterial occlusive Sangamo Biosciences Inc.
disease therapy
Zolip Phase III clinical trials Dyslipidemia Cholesterol reducers Solvay Pharmaceuticals Inc.
ZP120 Phase II clinical trials Acute heart failure Cardiovascular drugs Zealand Pharma AS
59
TOP 15 THERAPEUTIC GROUPS: DIABETES AND METABOLIC DISORDERS
Developer/partner
developer
189075 Phase II clinical trials Type 2 diabetes Diabetes drugs GlaxoSmithKline Inc.
376501 Phase I clinical trials Type 2 diabetes Diabetes drugs GlaxoSmithKline Inc.
756050 Phase I clinical trials Type 2 diabetes Diabetes drugs GlaxoSmithKline Inc.
Acid Sphingomyelinase Phase I clinical trials Niemann-Pick disease type B Metabolic disorder treatments Genzyme Corp.
Acomplia Phase III clinical trials Type 2 diabetes Diabetes drugs Sanofi-Aventis
Actoplus Met Extended- Awaiting approval Type 2 diabetes Diabetes drugs Takeda Pharmaceuticals
Release North America Inc.,
Watson Pharmaceuticals Inc.
AGI-1067 Phase III clinical trials Type 2 diabetes Diabetes drugs AtheroGenics Inc.
AJD101 Phase I clinical trials Insulin signaling pathway Diabetes drugs Daiichi Sankyo Inc.
activation
AKP-020 Phase II clinical trials Type 2 diabetes Diabetes drugs Akesis Pharmaceuticals Inc.
AKP-111 Phase I clinical trials Diabetes Diabetes drugs Akesis Pharmaceuticals Inc.
AKP-201 Phase I clinical trials Diabetes Diabetes drugs Akesis Pharmaceuticals Inc.
Alogliptin Awaiting approval Type 2 diabetes Diabetes drugs Takeda Pharmaceuticals
North America Inc.
Alogliptin/Actos Awaiting approval Type 2 diabetes Diabetes drugs Takeda Pharmaceuticals
North America Inc.
ALTU-237 Phase I clinical trials Primary hyperoxaluria Metabolic disorder treatments Altus Pharmaceuticals Inc.
AMG 221 Phase I clinical trials Type 2 diabetes Diabetes drugs Amgen Inc.
AMG 222 Phase II clinical trials Type 2 diabetes Diabetes drugs Amgen Inc.
AMG 477 Phase I clinical trials Type 2 diabetes Diabetes drugs Amgen Inc.
Androxal Phase II clinical trials Metabolic syndrome Metabolic disorder treatments Repros Therapeutics Inc.
APP018 Phase I clinical trials Atherosclerosis Metabolic disorder treatments Novartis
ARI-2243 Phase I clinical trials Type 2 diabetes Diabetes drugs Arisaph Pharmaceuticals Inc.
ASP1941 Phase II clinical trials Type 2 diabetes Diabetes drugs Astellas Pharma US Inc.,
Kotobuki Pharmaceutical Co.
AT-1001 Phase I clinical trials Type 1 diabetes Diabetes drugs Alba Therapeutics Corp.
ATL844 Phase II clinical trials Diabetes Diabetes drugs Clinical Data Inc.
Avandamet XR Phase III clinical trials Type 2 diabetes Diabetes drugs GlaxoSmithKline Inc.
Avandia Awaiting approval Type 2 diabetes progression Diabetes drugs GlaxoSmithKline Inc.
prevention
Avandia and Simvastatin Phase III clinical trials Type 2 diabetes Diabetes drugs GlaxoSmithKline Inc.
AVE0010 Once Daily Phase III clinical trials Type 2 diabetes Diabetes drugs Sanofi-Aventis
AVE0010 Prolonged-Release Phase I clinical trials Type 2 diabetes Diabetes drugs Sanofi-Aventis
AVE0010 Twice Daily Phase III clinical trials Type 2 diabetes Diabetes drugs Sanofi-Aventis
AVE0847 Phase II clinical trials Type 2 diabetes Diabetes drugs Sanofi-Aventis
AVE0897 Phase I clinical trials Type 2 diabetes Diabetes drugs Sanofi-Aventis
AVI-4557 Phase II clinical trials Metabolic redirection Metabolic disorder treatments AVI BioPharma Inc.
AZD1175 Phase I clinical trials Diabetes Diabetes drugs AstraZeneca
Pharmaceuticals LP
AZD1656 Phase I clinical trials Diabetes Diabetes drugs AstraZeneca
Pharmaceuticals LP
AZD2207 Phase II clinical trials Diabetes Diabetes drugs AstraZeneca
Pharmaceuticals LP
AZD6370 Phase II clinical trials Diabetes Diabetes drugs AstraZeneca
Pharmaceuticals LP
60
Developer/partner
developer
Balaglitazone Phase III clinical trials Type 2 diabetes Diabetes drugs Rheoscience A/S, Dr. Reddy’s
Laboratories Inc.
Basal Insulin Transdermal Phase I clinical trials Type 1 and type 2 diabetes Diabetes drugs Altea Therapeutics
Patch
Basulin Phase II clinical trials Type 2 diabetes Diabetes drugs Flamel Technologies Inc.
BHT-3021 Phase I/II clinical trials Type 1 diabetes Diabetes drugs Bayhill Therapeutics Inc.
BT16 Phase I clinical trials Metabolic syndrome Metabolic disorder treatments Quark Pharmaceuticals Inc.
CE-326597 Phase II clinical trials Diabetes Diabetes drugs Pfizer Inc.
Convivia Phase II clinical trials Metabolic diseases Metabolic disorder treatments Bennu Pharmaceuticals Inc.
CRx-401 Phase II clinical trials Type 2 diabetes Diabetes drugs CombinatoRx Inc.
CS-011 Phase III clinical trials Diabetes Diabetes drugs Daiichi Sankyo Inc.
CVT-3619 Phase I clinical trials Diabetes Diabetes drugs CV Therapeutics Inc.
CVT-3619 Phase I clinical trials Metabolic syndrome Metabolic disorder treatments CV Therapeutics Inc.
CVT-3619 Phase I clinical trials Cardiometabolic diseases Metabolic disorder treatments CV Therapeutics Inc.
Cycloset Awaiting approval Type 2 diabetes Diabetes drugs VeroScience LLC
Dapagliflozin Phase III clinical trials Diabetes Diabetes drugs Bristol-Myers Squibb Co.,
AstraZeneca
Pharmaceuticals LP
Diamyd Phase III clinical trials Type 1 diabetes Diabetes drugs Diamyd Medical AB
DiaPep277 Phase II clinical trials Diabetes Diabetes drugs Clal Biotechnology Industries
Ltd.
DIO-901 Phase II clinical trials Hypoglycemia Diabetes drugs DiObex Inc.
DIO-902 Phase II clinical trials Type 2 diabetes Diabetes drugs DiObex Inc.
DSP-8658 Phase I clinical trials Diabetes Diabetes drugs Dainippon Sumitomo
Pharma Co.
E1-I.N.T. Phase II clinical trials Type 1 diabetes Diabetes drugs Transition Therapeutics Inc.
EMD 675992 Phase II clinical trials Type 2 diabetes Diabetes drugs EMD Serono Inc.
ENB-0040 Phase I clinical trials Hypophosphatasia Metabolic disorder treatments Enobia Pharma
Exenatide LAR Once-a-Week Phase III clinical trials Type 2 diabetes Diabetes drugs Amylin Pharmaceuticals Inc.,
Eli Lilly and Co.
Exenatide Nasal Spray Phase I clinical trials Type 2 diabetes Diabetes drugs Amylin Pharmaceuticals Inc.,
MDRNA Inc.
G4544 Phase I clinical trials Hypercalcemia Metabolic disorder treatments Genta Inc.
Galvus Awaiting approval Type 2 diabetes Diabetes drugs Novartis
Galvus Fixed-Dose Awaiting approval Type 2 diabetes Diabetes drugs Novartis Pharmaceuticals
Combination Corp.
Glinsuna Phase III clinical trials Type 2 diabetes Diabetes drugs Elixir Pharmaceuticals Inc.
GLP-1 Analog Phase II clinical trials Type 2 diabetes Diabetes drugs Eli Lilly and Co.
Glufast Phase III clinical trials Type 2 diabetes Diabetes drugs Elixir Pharmaceuticals Inc.
INCB13739 Phase II clinical trials Type 2 diabetes Diabetes drugs Incyte Corp.
INCB19602 Phase I clinical trials Type 2 diabetes Diabetes drugs Incyte Corp.
INCB20817 Phase I clinical trials Type 2 diabetes Diabetes drugs Incyte Corp.
Inhaled Insulin Phase I clinical trials Diabetes Diabetes drugs Innovata Plc.
Insulin Nasal Spray Phase II clinical trials Type 2 diabetes Diabetes drugs MDRNA Inc.
INT131 Phase II clinical trials Type 2 diabetes Diabetes drugs InteKrin Therapeutics Inc.
Iplex Phase II clinical trials Type 1 diabetes Diabetes drugs Insmed Inc.
Iplex Phase II clinical trials HIV-associated adipose Metabolic disorder treatments Insmed Inc.
redistribution syndrome
Iroxanadine Phase I clinical trials Diabetic foot ulcers Diabetes drugs CytRx Corp.
Isis 113715 Phase II clinical trials Type 2 diabetes Diabetes drugs Isis Pharmaceuticals Inc.
Isis 325568 Phase I clinical trials Type 2 diabetes Diabetes drugs Ortho-McNeil Inc.
61
Developer/partner
developer
JNJ-39659100 Phase II clinical trials Type 2 diabetes Diabetes drugs Ortho-McNeil Inc.
KB3305 Phase I/II clinical trials Type 2 diabetes Diabetes drugs Karo Bio AB
KD7040 Phase I clinical trials Metabolic diseases Metabolic disorder treatments Kalypsys Inc.
Liraglutide Awaiting approval Type 2 diabetes Diabetes drugs Novo Nordisk Inc.
Lisofylline Phase II clinical trials Type 1 diabetes Diabetes drugs DiaKine Therapeutics Inc.
LY2599506 Phase I clinical trials Diabetes Diabetes drugs Eli Lilly and Co.
MB07803 Phase II clinical trials Type 2 diabetes Diabetes drugs Metabasis Therapeutics Inc.
MBX-2044 Phase II clinical trials Type 2 diabetes Diabetes drugs Ortho-McNeil Inc.
MBX-2982 Phase I clinical trials Type 2 diabetes Diabetes drugs Metabolex Inc.
Metgluna Phase III clinical trials Type 2 diabetes Diabetes drugs Elixir Pharmaceuticals Inc.
MK-0893 Phase II clinical trials Diabetes Diabetes drugs Merck & Co.
MK-0941 Phase I clinical trials Diabetes Diabetes drugs Merck & Co.
MP-513 Phase I clinical trials Type 2 diabetes Diabetes drugs Mitsubishi Tanabe
Pharma Corp.
Nasulin Phase II clinical trials Postprandial hyperglycemia Diabetes drugs CPEX Pharmaceuticals Inc.
Nasulin Phase II clinical trials Diabetes Diabetes drugs CPEX Pharmaceuticals Inc.
Naturlose Phase III clinical trials Type 2 diabetes Diabetes drugs Spherix Inc.
NCX 4016 Phase II clinical trials Type 2 diabetes Diabetes drugs NicOx Inc.
NGD-4715 Phase I clinical trials Diabetes Diabetes drugs Neurogen Corp.
NN1250 Phase II clinical trials Type 1 diabetes Diabetes drugs Novo Nordisk Inc.
NovoMix 50 Awaiting approval Type 1 diabetes Diabetes drugs Novo Nordisk Inc.
NovoMix 50 Awaiting approval Type 2 diabetes Diabetes drugs Novo Nordisk Inc.
Ondero Phase III clinical trials Diabetes Diabetes drugs Boehringer Ingelheim
Onglyza Awaiting approval Type 2 diabetes Diabetes drugs Bristol-Myers Squibb Co.,
AstraZeneca
Pharmaceuticals LP
Onglyza/Metformin Phase III clinical trials Diabetes Diabetes drugs Bristol-Myers Squibb Co.,
Combination AstraZeneca
Pharmaceuticals LP
Oral HDV-Insulin Phase II clinical trials Diabetes mellitus Diabetes drugs Diasome
Oral Insulin Phase II clinical trials Type 2 diabetes Diabetes drugs Emisphere Technologies Inc.
Oral-lyn Phase III clinical trials Type 1 diabetes Diabetes drugs Generex Biotechnology Corp.
OREX-003 Phase II clinical trials Metabolic disorders Metabolic disorder treatments Orexigen Therapeutics Inc.
Otelixizumab Phase III clinical trials Type 1 diabetes Diabetes drugs Tolerx Inc.
Oxabact Phase II/III clinical trials Primary hyperoxaluria Metabolic disorder treatments OxThera Inc.
PC-DAC:Exendin-4 Phase II clinical trials Type 2 diabetes Diabetes drugs ConjuChem Inc.
PF-2575799 Phase I clinical trials Diabetes Diabetes drugs Pfizer Inc.
PF-4325667 Phase I clinical trials Diabetes Diabetes drugs Pfizer Inc.
PF-734200 Phase II clinical trials Type 2 diabetes Diabetes drugs Pfizer Inc.
PH20 Phase I/II clinical trials Diabetes mellitus Diabetes drugs Halozyme Therapeutics Inc.
PHX1149 Phase II clinical trials Type 2 diabetes Diabetes drugs Phenomix Corp.
62
Developer/partner
developer
PPM-204 Phase II clinical trials Type 2 diabetes Diabetes drugs Plexxikon Inc.,
Prochymal Phase II clinical trials Type 1 diabetes Diabetes drugs Osiris Therapeutics Inc.
PSN010 Phase I clinical trials Type 2 diabetes Diabetes drugs Eli Lilly and Co.
PSN821 Phase I clinical trials Type 2 diabetes Diabetes drugs OSI Pharmaceuticals Inc.
Qnexa Phase II clinical trials Type 2 diabetes Diabetes drugs Vivus Inc.
QR-449 Phase I clinical trials Metabolic syndrome Metabolic disorder treatments Quigley Pharma Inc.
R1439 Phase II clinical trials Type 2 diabetes Diabetes drugs Hoffmann-La Roche Inc.
R1511 Phase I clinical trials Type 2 diabetes Diabetes drugs Hoffmann-La Roche Inc.
R1579 Phase II clinical trials Type 2 diabetes Diabetes drugs Hoffmann-La Roche Inc.
R1583 Phase III clinical trials Type 2 diabetes Diabetes drugs Hoffmann-La Roche Inc.
Safflower-Produced Insulin Phase I/II clinical trials Diabetes Diabetes drugs SemBioSys Genetics Inc.
SAR7226 Phase I clinical trials Type 2 diabetes Diabetes drugs Sanofi-Aventis
Serostim Awaiting approval HIV-associated adipose Metabolic disorder treatments EMD Serono Inc.
redistribution syndrome
SRT501 Phase II clinical trials Type 2 diabetes Diabetes drugs Sirtris Pharmaceuticals Inc.
Starlix/Diovan Combination Phase III clinical trials Type 2 diabetes Diabetes drugs Novartis
Syncria Phase II clinical trials Type 2 diabetes Diabetes drugs GlaxoSmithKline Inc.
SYR-472 Phase II clinical trials Diabetes mellitus Diabetes drugs Takeda Pharmaceuticals
North America Inc.
TA-6666 Phase II clinical trials Type 2 diabetes Diabetes drugs Mitsubishi Tanabe
Pharma Corp.
Technosphere Insulin Phase III clinical trials Type 1 diabetes Diabetes drugs MannKind Corp.
Technosphere Insulin Phase III clinical trials Type 2 diabetes Diabetes drugs MannKind Corp.
Teplizumab Phase III clinical trials Type 1 diabetes Diabetes drugs Eli Lilly and Co.
Thymoglobulin Phase I clinical trials Type 1 diabetes Diabetes drugs Genzyme Corp.
TPM-02/Insulin Phase II clinical trials Diabetes Diabetes drugs Phosphagenics Ltd.
Triolex Phase II clinical trials Type 2 diabetes Diabetes drugs Hollis-Eden
Triolex Phase I/II clinical trials Metabolic disorders Metabolic disorder treatments Hollis-Eden
Trodusquemine Phase I clinical trials Type 2 diabetes Diabetes drugs Genaera Corp.
TS-033 Phase II clinical trials Type 2 diabetes Diabetes drugs Taisho Pharmaceutical Co.
TS-033 Phase II clinical trials Type 1 diabetes Diabetes drugs Taisho Pharmaceutical Co.
TT-223 Phase II clinical trials Type 2 diabetes Diabetes drugs Eli Lilly and Co.
VGX-1027 Phase I clinical trials Type 1 diabetes Diabetes drugs VGX Pharmaceuticals
VIAject Phase III clinical trials Diabetes Diabetes drugs Biodel Inc.
VIAtab Phase I clinical trials Diabetes Diabetes drugs Biodel Inc.
XOMA 052 Phase I clinical trials Type 2 diabetes Diabetes drugs Xoma Ltd.
63
TOP 15 THERAPEUTIC GROUPS: PAIN/INFLAMMATION
Developer/partner
developer
842166 Phase II clinical trials Inflammatory pain Analgesics GlaxoSmithKline Inc.
ABT-102 Phase I clinical trials Pain Analgesics Abbott Laboratories
Acetavance Phase III clinical trials Acute pain Analgesics Cadence
Acetavance Phase III clinical trials Pain Analgesics Cadence
Acurox Tablets Phase III clinical trials Postoperative pain Analgesics Acura Pharmaceuticals Inc.,
King Pharmaceuticals Inc.
AD 923 Phase I clinical trials Cancer pain Analgesics Sosei Co.
ADL5747 Phase I clinical trials Pain Analgesics Adolor Corp., Pfizer Inc.
ADL5859 Phase II clinical trials Pain Analgesics Adolor Corp., Pfizer Inc.
ADL5859 Phase II clinical trials Inflammatory pain Analgesics Adolor Corp., Pfizer Inc.
ADL5859 Phase II clinical trials Acute pain Analgesics Adolor Corp., Pfizer Inc.
Adlea Phase II clinical trials Tendonitis Analgesics Anesiva Inc.
Adlea Phase II clinical trials Morton neuroma Analgesics Anesiva Inc.
Adlea Phase II/III clinical trials Osteoarthritis pain Analgesics Anesiva Inc.
Adlea Phase III clinical trials Postsurgical pain Analgesics Anesiva Inc.
AeroLEF Phase II clinical trials Acute pain Analgesics YM BioSciences Inc.
AeroLEF Phase II clinical trials Postoperative pain Analgesics YM BioSciences Inc.
Afimoxifene Phase II clinical trials Mastalgia Analgesics Ascend Therapeutics Inc.
AM103 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents GlaxoSmithKline Inc.
AM803 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents GlaxoSmithKline Inc.
Ameloir Phase III clinical trials Pain Analgesics Cumberland
AMG 379 Phase I clinical trials Pain Analgesics Amgen Inc.
Anti-VAP1 Antibody Phase I clinical trials Inflammation Anti-inflammatory agents Medarex Inc.
APF112 Phase II clinical trials Postsurgical pain Analgesics AP Pharma Inc.
Apremilast Phase II clinical trials Behcet’s disease Anti-inflammatory agents Celgene Corp.
Arcoxia Awaiting approval Pain Analgesics Merck & Co.
ARRY-614 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents Array BioPharma Inc.
ARRY-797 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents Array BioPharma Inc.
ARRY-797 Phase II clinical trials Postoperative pain Analgesics Array BioPharma Inc.
ARRY-797 Phase II clinical trials Inflammatory pain Analgesics Array BioPharma Inc.
AVR118 Phase II clinical trials Inflammation Anti-inflammatory agents Advanced Viral
Research Corp.
AZ-003 Phase I clinical trials Acute pain Analgesics Alexza Pharmaceuticals Inc.,
Endo Pharmaceuticals Inc.
AZD1940 Phase II clinical trials Nociceptive pain Analgesics AstraZeneca
Pharmaceuticals LP
BEMA Buprenorphine Phase I clinical trials Pain Analgesics BioDelivery Sciences
International Inc.
BEMA LA Phase I clinical trials Pain Analgesics BioDelivery Sciences
International Inc.
Bicifadine Phase II clinical trials Osteoarthritis pain Analgesics XTL Biopharmaceuticals Inc.
Botulinum Toxin Phase I clinical trials Pain Analgesics Mentor Corp.
Budesonide MMX Phase III clinical trials Inflammation Anti-inflammatory agents Cosmo Pharmaceuticals
Bupivacaine Implant Phase II clinical trials Postoperative pain Analgesics Innocoll Inc.
Cannabinor Phase II clinical trials Pain Analgesics Pharmos Corp.
CB1400 Phase II clinical trials Chemotherapy-induced Anti-inflammatory agents Canopus BioPharma Inc.
oral mucositis
CC-11006 Phase II clinical trials Inflammatory diseases Anti-inflammatory agents Celgene Corp.
64
Developer/partner
developer
CC-11050 Phase II clinical trials Inflammatory diseases Anti-inflammatory agents Celgene Corp.
CEP-28190 Phase I clinical trials Pain Analgesics Cephalon Inc.
CIP-Tramadol ER Awaiting approval Pain Analgesics Cipher Pharmaceuticals Inc.
CR665 Phase I clinical trials Postoperative pain Analgesics Alza Corp.
CR845 Phase I clinical trials Pain Analgesics Cara Therapeutics Inc.
CR845 Phase I clinical trials Inflammatory pain Analgesics Cara Therapeutics Inc.
CR845 Phase I clinical trials Neuropathic pain Analgesics Cara Therapeutics Inc.
CRx-170 Phase II clinical trials Chronic pain Analgesics CombinatoRx Inc.
CVT-6883 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents CV Therapeutics Inc.
Cymbalta Awaiting approval Chronic pain Analgesics Eli Lilly and Co.
DepoBupivacaine Phase III clinical trials Postsurgical pain Analgesics Pacira Pharmaceuticals Inc.
Diclofenac Phase II/III clinical trials Chronic pain Analgesics Cerimon Pharmaceuticals Inc.
Diclofenac Phase II clinical trials Osteoarthritis pain Analgesics Pharmos Corp.
NanoEmulsion Cream
Diractin Phase III clinical trials Pain Analgesics Alpharma Inc.
Dyloject Phase III clinical trials Acute pain Analgesics Javelin Pharmaceuticals Inc.
Eladur Phase II clinical trials Post-herpetic neuralgia Analgesics Alpharma Inc.
ELI-154 Phase III clinical trials Pain Analgesics Elite Pharmaceuticals Inc.
Embeda Awaiting approval Chronic pain Analgesics Alpharma Inc.
EN 3285 Phase III clinical trials Oral mucositis Anti-inflammatory agents Endo Pharmaceuticals Inc.
EPB-348 Phase II clinical trials Post-herpetic neuralgia Analgesics Epiphany Biosciences Inc.
EpiCept NP-1 Phase III clinical trials Post-herpetic neuralgia Analgesics EpiCept Corp.
Fentanyl Citrate Phase II clinical trials Chronic pain Analgesics Altea Therapeutics
Transdermal Patch
Fentora Awaiting approval Chronic pain Analgesics Cephalon Inc.
Forteo Phase III clinical trials Back pain Analgesics Eli Lilly and Co.
Gabapentin GR Phase III clinical trials Post-herpetic neuralgia Analgesics DepoMed Inc.
GRC 6211 Phase II clinical trials Osteoarthritis pain Analgesics Eli Lilly and Co.
Human Lactoferrin Phase I clinical trials Inflammatory diseases Anti-inflammatory agents Pharming Group NV,
Gem Pharmaceuticals Inc.
HZT-501 Phase III clinical trials Pain Analgesics Horizon Therapeutics
Ibuprofen-PC Phase III clinical trials Osteoarthritis pain Analgesics PLx Pharma Inc.
iGluR5 Antagonist Phase I clinical trials Pain Analgesics Eli Lilly and Co.
Intestinal Trefoil Factor Phase II clinical trials Mucositis Anti-inflammatory agents The GI Company Inc.
Intranasal Hydomorphone Phase II clinical trials Acute pain Analgesics Intranasal Therapeutics Inc.
IoGen Phase III clinical trials Cyclic mastalgia Analgesics Symbollon
Ketotransdel Phase III clinical trials Acute pain Analgesics Transdel Pharmaceuticals Inc.
Lacosamide Phase II clinical trials Osteoarthritis pain Analgesics UCB Pharma Inc.
Lidocaine Vaginal Gel Phase II clinical trials Dysmenorrhea Analgesics Columbia Laboratories Inc.
LidoPain BP Phase II clinical trials Acute pain Analgesics EpiCept Corp.
LidoPain SP Phase II clinical trials Postsurgical pain Analgesics EpiCept Corp.
LT-NS001 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents Logical Therapeutics Inc.
Lyrica Phase III clinical trials Postoperative pain Analgesics Pfizer Inc.
M40403 Phase II clinical trials Oral mucositis Anti-inflammatory agents ActivBiotics Inc.
M6G Phase I clinical trials Postoperative pain Analgesics Cenes Pharmaceuticals Plc.
MGX-001 Phase II clinical trials Pain Analgesics Victory Pharma Inc.
MK-0974 Phase III clinical trials Migraine Analgesics Merck & Co.
MK-2295 Phase II clinical trials Pain Analgesics Merck & Co.
65
Developer/partner
developer
Nalbuphine ER Phase II clinical trials Chronic pain Analgesics Penwest Pharmaceuticals Co.
Nasalfent Phase III clinical trials Cancer pain Analgesics Archimedes Pharma Ltd.
NMED-1077 Phase III clinical trials Chronic pain Analgesics NeuroMed
NP2 Phase I clinical trials Pain Analgesics Diamyd Inc.
NRP290 Phase II clinical trials Acute pain Analgesics Shire US Inc.
NU206 Phase I clinical trials Mucositis Anti-inflammatory agents Nuvelo Inc.,
NXN-188 Phase II clinical trials Acute migraine Analgesics NeurAxon Inc.
OMS103HP Phase III clinical trials Postoperative joint pain Analgesics Omeros Corp.
OMS201 Phase I clinical trials Inflammation Anti-inflammatory agents Omeros Corp.
OMS201 Phase I clinical trials Pain Analgesics Omeros Corp.
Onsolis Awaiting approval Cancer pain Analgesics BioDelivery Sciences
International Inc.
Oxiplex Gel Awaiting approval Postsurgical pain Analgesics FzioMed Inc.
OxyTrex Phase III clinical trials Pain Analgesics Pain Therapeutics Inc.
P2X7 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents Renovis Inc.
PF-2393296 Phase I clinical trials Pain Analgesics Pfizer Inc.
PF-4383119 Phase II clinical trials Pain Analgesics Pfizer Inc.
PF-4856880 Phase II clinical trials Pain Analgesics Pfizer Inc.
PH-797804 Phase II clinical trials Pain Analgesics Pfizer Inc.
PL 2100 Phase I clinical trials Pain Analgesics PLx Pharma Inc.
PLX5568 Phase I clinical trials Pain Analgesics Plexxikon Inc.
PMI-150 Phase III clinical trials Pain Analgesics Javelin Pharmaceuticals Inc.
PMI-150 Phase III clinical trials Cancer pain Analgesics Javelin Pharmaceuticals Inc.
Posidur Phase II clinical trials Postoperative pain Analgesics Durect Corp.,
Nycomed Group
Prexige Awaiting approval Acute pain Analgesics Novartis
Probuphine Phase I clinical trials Chronic pain Analgesics Titan Pharmaceuticals Inc.
PTI-202 Phase I clinical trials Pain Analgesics Pain Therapeutics Inc.,
PTI-721 Phase I clinical trials Pain Analgesics Pain Therapeutics Inc.,
Q8003IR Phase III clinical trials Pain Analgesics QRxPharma Ltd.
QSC-001 Phase I clinical trials Pain Analgesics Questcor
R1646 Phase I clinical trials Pain Analgesics Hoffmann-La Roche Inc.
Rapinyl Phase III clinical trials Cancer pain Analgesics ProStrakan Group Plc.
RDEA119 Phase I clinical trials Inflammatory diseases Anti-inflammatory agents Ardea Biosciences Inc.
Remoxy Awaiting approval Chronic pain Analgesics Pain Therapeutics Inc.,
Retigabine Phase II clinical trials Neuralgia Analgesics GlaxoSmithKline Inc.
RGH-896 Phase II clinical trials Chronic pain Analgesics Forest Laboratories Inc.
RK-0202 Phase II clinical trials Oral mucositis Anti-inflammatory agents RxKinetix Inc.
ROX-828 Phase II clinical trials Migraine Analgesics Roxro Pharma Inc.
66
Developer/partner
developer
ROX-888 Phase III clinical trials Acute pain Analgesics Roxro Pharma Inc.
RTA 402 Phase II clinical trials Inflammation Anti-inflammatory agents Reata Pharmaceuticals Inc.
Rylomine Phase III clinical trials Postoperative pain Analgesics Javelin Pharmaceuticals Inc.
Saforis Phase III clinical trials Oral mucositis Anti-inflammatory agents MGI Pharma Inc.
Sativex Phase II clinical trials Cancer pain Analgesics Otsuka Pharmaceutical
Development &
SNX-1012 Phase II clinical trials Oral mucositis Anti-inflammatory agents Serenex Inc.
SSR150106 Phase II clinical trials Pain Analgesics Sanofi-Aventis
SYN-116 Phase I clinical trials Pain Analgesics Synosia Therapeutics
Tapentadol ER Phase III clinical trials Chronic pain Analgesics Johnson & Johnson
Development
Tapentadol IR Awaiting approval Pain Analgesics Johnson & Johnson
Development
TPM-01/Morphine Phase II clinical trials Chronic pain Analgesics Phosphagenics Ltd.
Transacin Awaiting approval Post-herpetic neuralgia Analgesics NeurogesX Inc.
Transdur Sufentanil Phase II clinical trials Chronic pain Analgesics Endo Pharmaceuticals Inc.
Tridural Awaiting approval Pain Analgesics Labopharm Inc.
Vicodin CR Awaiting approval Pain Analgesics Abbott Laboratories
VR1 Phase I clinical trials Pain Analgesics Pfizer Inc.
VT-211 Phase I clinical trials Chemotherapy-induced Anti-inflammatory agents Vicus Therapeutics
oral mucositis
VT-212 Phase I clinical trials Chemotherapy-induced Anti-inflammatory agents Vicus Therapeutics
oral mucositis
Xen2174 Phase I/II clinical trials Cancer pain Analgesics Xenome Ltd.
Xen2174 Phase II clinical trials Postoperative pain Analgesics Xenome Ltd.
XP13512/ 1838262 Phase II clinical trials Post-herpetic neuralgia Analgesics XenoPort Inc.,
Zipsor Awaiting approval Pain Analgesics Xanodyne
ZX002 Phase II clinical trials Chronic pain Analgesics Zogenix Inc.
67
TOP 15 THERAPEUTIC GROUPS: RESPIRATORY
Developer/partner
developer
1004723 Phase I clinical trials Allergic rhinitis Respiratory drugs GlaxoSmithKline Inc.
159797 Phase II clinical trials Chronic obstructive Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
159797 Phase II clinical trials Asthma Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
2190914 Phase I clinical trials Respiratory diseases Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
pulmonary disease
256066 Phase II clinical trials Allergic rhinitis Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
pulmonary disease
679586 Phase II clinical trials Severe asthma Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
pulmonary disease
784568 Phase II clinical trials Allergic rhinitis Respiratory drugs GlaxoSmithKline Inc.
835726 Phase I clinical trials Allergic rhinitis Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
pulmonary disease
A-001 Phase II clinical trials Acute chest syndrome Respiratory drugs Anthera Pharmaceuticals Inc.
Aclidinium/Formeterol Phase I clinical trials Chronic obstructive Respiratory drugs Forest Laboratories Inc.
Combination pulmonary disease
Advair Diskus 500/50 Awaiting approval Chronic obstructive Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
Aerosolized AAT Phase II/III clinical trials Congenital emphysema Respiratory drugs Kamada Ltd.
Aerosolized AAT Phase II clinical trials Bronchiectasis Respiratory drugs Kamada Ltd.
Aerosurf Phase II clinical trials Respiratory distress syndrome Respiratory drugs Discovery Laboratories Inc.
Aerovant Phase II clinical trials Asthma Respiratory drugs Aerovance Inc.
AGTC-0106 Phase I/II clinical trials Alpha-1 antitrypsin deficiency Respiratory drugs Applied Genetic
Technologies Corp.
AIR 645 Phase I clinical trials Asthma Respiratory drugs Altair Therapeutics Inc.
ALKS 27 Phase II clinical trials Chronic obstructive Respiratory drugs Alkermes Inc., Indevus
pulmonary disease Pharmaceuticals Inc.
AllerNase Awaiting approval Seasonal and perennial Respiratory drugs Collegium
allergic rhinitis Pharmaceutical Inc.
ALN-RSV01 Phase II clinical trials Respiratory syncytial virus Respiratory drugs Alnylam Pharmaceuticals Inc.
AMG 317 Phase II clinical trials Asthma Respiratory drugs Amgen Inc.
AMG 853 Phase I clinical trials Asthma Respiratory drugs Amgen Inc.
Anrukinzumab Phase II clinical trials Asthma Respiratory drugs Wyeth Pharmaceuticals
Anti-IL13 Phase I clinical trials Asthma Respiratory drugs Genentech Inc.
68
Developer/partner
developer
AP768 Phase I clinical trials Asthma Respiratory drugs Actimis Pharmaceuticals Inc.
ARD-1300 Phase II clinical trials Asthma Respiratory drugs Aradigm Corp.
Aridol Phase III clinical trials Asthma Respiratory drugs Pharmaxis Ltd.
Ariflo Awaiting approval Chronic obstructive Respiratory drugs GlaxoSmithKline Inc.
pulmonary disease
ASM8 Phase II clinical trials Allergic asthma Respiratory drugs Topigen Pharmaceuticals Inc.
ATL844 Phase II clinical trials Asthma Respiratory drugs Clinical Data Inc.
AVE0675 Phase I clinical trials Asthma Respiratory drugs Sanofi-Aventis
AZD1236 Phase I clinical trials Chronic obstructive Respiratory drugs AstraZeneca
pulmonary disease Pharmaceuticals LP
AZD1981 Phase II clinical trials Asthma Respiratory drugs AstraZeneca
Pharmaceuticals LP
AZD1981 Phase II clinical trials Chronic obstructive Respiratory drugs AstraZeneca
AZD3199 Phase I clinical trials Asthma Respiratory drugs AstraZeneca
Pharmaceuticals LP
AZD3199 Phase I clinical trials Chronic obstructive Respiratory drugs AstraZeneca
AZD8848 Phase I clinical trials Asthma Respiratory drugs AstraZeneca
Pharmaceuticals LP
Bilastine Phase III clinical trials Allergic rhinitis Respiratory drugs FAES Farma SA
BIO-11006 Phase II clinical trials Chronic obstructive Respiratory drugs BioMarck
pulmonary disease Pharmaceuticals Ltd.
Bronchitol Phase III clinical trials Bronchiectasis Respiratory drugs Pharmaxis Ltd.
Calfactant Phase II clinical trials Acute lung injury Respiratory drugs Pneuma Partners LLC
Calfactant Phase II clinical trials Respiratory distress syndrome Respiratory drugs Pneuma Partners LLC
CAT-354 Phase II clinical trials Asthma Respiratory drugs AstraZeneca
Pharmaceuticals LP
CP-690550 Phase II clinical trials Asthma Respiratory drugs Pfizer Inc.
CVT-6883 Phase I clinical trials Chronic pulmonary diseases Respiratory drugs CV Therapeutics Inc.
CX717 Phase II clinical trials Respiratory depression Respiratory drugs Cortex Pharmaceuticals Inc.
CXCR2 Receptor Antagonist Phase II clinical trials Chronic obstructive Respiratory drugs Schering-Plough Corp.
pulmonary disease
Daxas Phase III clinical trials Chronic obstructive Respiratory drugs Nycomed Group
pulmonary disease
DSP-3025 Phase I clinical trials Bronchial asthma Respiratory drugs Dainippon Sumitomo
Pharma Co.
DSP-3025 Phase I clinical trials Allergic rhinitis Respiratory drugs Dainippon Sumitomo
Pharma Co.
Eculizumab Phase I clinical trials Asthma Respiratory drugs Alexion Pharmaceuticals Inc.
Flutiform Phase III clinical trials Asthma Respiratory drugs SkyePharma Plc.,
Abbott Laboratories
Guaifenesin Combination Awaiting approval Cough Respiratory drugs Adams Respiratory
Therapeutics Inc.
HspE7 Phase II clinical trials Respiratory papillomatosis Respiratory drugs Nventa
HuMab-OX40L Phase I clinical trials Asthma Respiratory drugs Genentech Inc.
IFN-Beta (SNG-1) Phase I clinical trials Asthma Respiratory drugs Synairgen Plc.
IFN-Beta (SNG-2) Phase I clinical trials Chronic obstructive Respiratory drugs Synairgen Plc.
pulmonary disease
69
Developer/partner
developer
IMA-026 Phase I clinical trials Asthma Respiratory drugs Wyeth Pharmaceuticals
Intravenous AAT Phase III clinical trials Congenital emphysema Respiratory drugs Kamada Ltd.
INV-102 Phase II clinical trials Asthma Respiratory drugs Inverseon
KB001 Phase I/II clinical trials Intensive-care unit respiratory Respiratory drugs KaloBios Pharmaceuticals Inc.
assistance
KB002 Phase I/II clinical trials Asthma Respiratory drugs KaloBios Pharmaceuticals Inc.
KB003 Phase I/II clinical trials Asthma Respiratory drugs KaloBios Pharmaceuticals Inc.
LAS34273 Phase III clinical trials Chronic obstructive Respiratory drugs Laboratorios Almirall SA,
pulmonary disease Forest Laboratories Inc.
Liposomal Ciprofloxacin Phase II clinical trials Bronchiectasis Respiratory drugs Aradigm Corp.
M40403 Phase II clinical trials Asthma Respiratory drugs ActivBiotics Inc.
M40403 Phase II clinical trials Chronic obstructive Respiratory drugs ActivBiotics Inc.
pulmonary disease
MAP0005 Phase II clinical trials Asthma Respiratory drugs MAP Pharmaceuticals Inc.
MAP0005 Phase II clinical trials Chronic obstructive Respiratory drugs MAP Pharmaceuticals Inc.
pulmonary disease
MAP0010 Phase III clinical trials Asthma Respiratory drugs MAP Pharmaceuticals Inc.
MEDI-528 Phase II clinical trials Asthma Respiratory drugs MedImmune Inc.
MEDI-557 Phase I clinical trials Respiratory syncytial virus Respiratory drugs MedImmune Inc.
MEDI-563 Phase I clinical trials Asthma Respiratory drugs MedImmune Inc.
MEDI-564 Phase I clinical trials Respiratory syncytial virus Respiratory drugs MedImmune Inc.
Mepolizumab Phase II clinical trials Asthma Respiratory drugs GlaxoSmithKline Inc.
Mepolizumab Phase II clinical trials Nasal polyposis Respiratory drugs GlaxoSmithKline Inc.
MK-0633 Phase II clinical trials Respiratory diseases Respiratory drugs Merck & Co.
MLN0415 Phase I clinical trials Chronic obstructive Respiratory drugs Millennium: The Takeda
pulmonary disease Oncology Company,
Sanofi-Aventis
MN-001 Phase II clinical trials Asthma Respiratory drugs MediciNova Inc.
MN-221 Phase II clinical trials Status asthmaticus Respiratory drugs MediciNova Inc.
MN-221 Phase II clinical trials Asthma Respiratory drugs MediciNova Inc.
Mometasone/Formoterol Phase III clinical trials Asthma Respiratory drugs Novartis Pharmaceuticals
Combination Corp., Schering-Plough Corp.
Mometasone/Formoterol Phase III clinical trials Chronic obstructive Respiratory drugs Novartis Pharmaceuticals
Combination pulmonary disease Corp., Schering-Plough Corp.
Motavizumab Awaiting approval Respiratory syncytial virus Respiratory drugs MedImmune Inc.
Mucinex with Codeine Awaiting approval Cough Respiratory drugs Adams Respiratory
Therapeutics Inc.
N30-201 Phase I clinical trials Asthma Respiratory drugs N30 Pharma Inc.
Nasonex Phase III clinical trials Rhinosinusitis Respiratory drugs Schering-Plough Corp.
NVA237 Phase II clinical trials Chronic obstructive Respiratory drugs Novartis
pulmonary disease Pharmaceuticals Corp.
Oglemilast Phase II clinical trials Chronic obstructive Respiratory drugs Forest Laboratories Inc.
pulmonary disease
Oglemilast Phase II clinical trials Asthma Respiratory drugs Forest Laboratories Inc.
PF-3526299 Phase I clinical trials Asthma Respiratory drugs Pfizer Inc.
PF-3635659 Phase I clinical trials Chronic obstructive Respiratory drugs Pfizer Inc.
pulmonary disease
pulmonary disease
pulmonary disease
70
Developer/partner
developer
PF-610355 Phase II clinical trials Asthma Respiratory drugs Pfizer Inc.
pulmonary disease
PH-797804 Phase II clinical trials Chronic obstructive Respiratory drugs Pfizer Inc.
pulmonary disease
Pleconaril Phase II clinical trials Asthma exacerbations Respiratory drugs Schering-Plough Corp.
QAB/Mometasone Phase II clinical trials Asthma Respiratory drugs Novartis Pharmaceuticals
Combination Corp., Schering-Plough Corp.
QAB/Mometasone Phase II clinical trials Chronic obstructive Respiratory drugs Novartis Pharmaceuticals
Combination pulmonary disease Corp., Schering-Plough Corp.
QAB149 Phase III clinical trials Chronic obstructive Respiratory drugs Novartis
QAE397 Phase II clinical trials Asthma Respiratory drugs Novartis
QAT370 Phase II clinical trials Chronic obstructive Respiratory drugs Novartis
QAX935 Phase I clinical trials Asthma Respiratory drugs Novartis
Pharmaceuticals Corp.,
Idera Pharmaceuticals Inc.
QAX935 Phase I clinical trials Allergies Respiratory drugs Novartis
Idera Pharmaceuticals Inc.
QMF149 Phase II clinical trials Chronic obstructive Respiratory drugs Novartis
QMF149 Phase II clinical trials Asthma Respiratory drugs Novartis
QVA149 Phase II clinical trials Chronic obstructive Respiratory drugs Novartis
R(+) zileuton Phase I clinical trials Asthma Respiratory drugs Critical Therapeutics Inc.
R1671 Phase I clinical trials Asthma Respiratory drugs Hoffmann-La Roche Inc.,
Genmab Inc.
R343 Phase I clinical trials Allergic asthma Respiratory drugs Pfizer Inc.
R4930 Phase I clinical trials Asthma Respiratory drugs Hoffmann-La Roche Inc.,
Genmab Inc.
R667 Phase II clinical trials Emphysema Respiratory drugs Hoffmann-La Roche Inc.
R7103 Phase I clinical trials Chronic obstructive Respiratory drugs Hoffmann-La Roche Inc.
pulmonary disease
Respriva Phase II clinical trials Hereditary emphysema Respiratory drugs Arriva Pharmaceuticals Inc.
Respriva Phase I clinical trials Chronic obstructive Respiratory drugs Arriva Pharmaceuticals Inc.
pulmonary disease
RSV604 Phase I clinical trials Respiratory syncytial virus Respiratory drugs Novartis
SAR389644 Phase I clinical trials Asthma Respiratory drugs Sanofi-Aventis
SAR389644 Phase I clinical trials Allergic rhinitis Respiratory drugs Sanofi-Aventis
Senicapoc Phase I clinical trials Asthma Respiratory drugs Icagen Inc.
SMP-028 Phase I clinical trials Bronchial asthma Respiratory drugs Dainippon Sumitomo
Pharma Co.
Sublingual Tablet-Based Phase III clinical trials Grass pollen allergies Respiratory drugs Schering-Plough Corp.
Immunotherapy
Sublingual Tablet-Based Phase II clinical trials Dust mite allergies Respiratory drugs Schering-Plough Corp.
Immunotherapy
Sublingual Tablet-Based Phase II clinical trials Ragweed allergies Respiratory drugs Schering-Plough Corp.
Immunotherapy
Sublingual-Oral Phase III clinical trials Allergies Respiratory drugs Greer Laboratories Inc.
Immunotherapy
71
Developer/partner
developer
SUN 1334 H Phase II clinical trials Seasonal and allergic rhinitis Respiratory drugs Sun Pharmaceutical
Industries Ltd.
Surfaxin Phase II clinical trials Acute respiratory distress Respiratory drugs Discovery Laboratories Inc.
syndrome
Surfaxin Awaiting approval Respiratory distress syndrome Respiratory drugs Discovery Laboratories Inc.
Surfaxin Phase II clinical trials Chronic lung disease Respiratory drugs Discovery Laboratories Inc.
Symbicort Awaiting approval Asthma Respiratory drugs AstraZeneca
Pharmaceuticals LP
Symbicort pMDI Awaiting approval Chronic obstructive Respiratory drugs AstraZeneca
TD-4208 Phase I clinical trials Chronic obstructive Respiratory drugs Theravance Inc.
pulmonary disease
Tetomilast Phase II clinical trials Chronic obstructive Respiratory drugs Otsuka Pharmaceutical
pulmonary disease Development &
Xolair Phase III clinical trials Allergic asthma Respiratory drugs Novartis Pharmaceuticals
Corp., Genentech Inc.
Xolair Liquid Phase III clinical trials Allergic asthma Respiratory drugs Novartis Pharmaceuticals
Corp., Genentech Inc.
Xopenex/Ipratropium Phase III clinical trials Chronic obstructive Respiratory drugs Sepracor Inc.
pulmonary disease
Zileuton I.V. Phase II clinical trials Asthma Respiratory drugs Critical Therapeutics Inc.
Zyflo Phase III clinical trials Chronic obstructive Respiratory drugs Critical Therapeutics Inc.
pulmonary disease
72
TOP 15 THERAPEUTIC GROUPS: VACCINES
Developer/partner
developer
Adacel Phase III clinical trials Diphtheria, tetanus and Vaccines Sanofi Pasteur
pertussis
Aflunov Phase II clinical trials Influenza Vaccines Novartis Vaccines and
Diagnostics
Anthrax Vaccine Phase II clinical trials Anthrax infection Vaccines Celldex Therapeutics Inc.,
DynPort Vaccine Company
LLC
AV7909 Phase I clinical trials Anthrax infection Vaccines Emergent BioSolutions Inc.
BCG-Ad35 Prime Boost Phase I clinical trials Tuberculosis Vaccines Crucell NV
Boostrix Awaiting approval Diphtheria, tetanus, and Vaccines GlaxoSmithKline Inc.
pertussis
C. Difficile Vaccine Phase I clinical trials Clostridium difficile infection Vaccines Acambis Plc.
CAIV-T Phase III clinical trials Influenza Vaccines MedImmune Inc.
Celvapan Phase I/II clinical trials Seasonal influenza Vaccines Baxter Healthcare Corp.
Cervarix Awaiting approval Human papillomavirus Vaccines GlaxoSmithKline Inc.,
infection MedImmune Inc.
ChimeriVax-JE Vaccine Phase III clinical trials Japanese encephalitis Vaccines Acambis Plc., Sanofi Pasteur
ChimeriVax-West Nile Phase II clinical trials West Nile virus infection Vaccines Acambis Plc.
Vaccine
CholeraGarde Phase II clinical trials Cholera Vaccines Celldex Therapeutics Inc.
CMV Vaccine Phase II clinical trials Congenital infection Vaccines Sanofi Pasteur
CMV Vaccine Phase I clinical trials Cytomegalovirus infection Vaccines AlphaVax Inc.
CMV Vaccine Phase I clinical trials Cytomegalovirus infection Vaccines AstraZeneca Pharmaceuticals
LP
CMX001 Phase I clinical trials Smallpox Vaccines Chimerix Inc
Cytomegalovirus Vaccine Phase II clinical trials Cytomegalovirus infection Vaccines Vical Inc.
Cytomegalovirus Vaccine Phase I clinical trials Cytomegalovirus infection Vaccines GlaxoSmithKline Inc.
Dengue Fever Vaccine Phase II clinical trials Dengue fever Vaccines GlaxoSmithKline Inc.
Dengue Vaccine Phase II clinical trials Dengue fever Vaccines Sanofi Pasteur
DNA Vaccine Phase II clinical trials HIV infection Vaccines Vical Inc.
DTP-HepB-Polio-Hib Vaccine Phase II clinical trials Diphtheria, tetanus, pertussis, Vaccines Sanofi Pasteur
hepatitis B, polio and
influenzae b
Ebola Vaccine Phase I clinical trials Ebola virus Vaccines Crucell NV
Epstein-Barr Virus Vaccine Phase II clinical trials Epstein-Barr virus infection Vaccines MedImmune Inc.,
ETEC E. Coli Vaccine Phase I clinical trials Enterotoxigenic Escherichia Vaccines Celldex Therapeutics Inc.
coli infection.
Flu Cell Vaccine Phase II clinical trials Influenza Vaccines Sanofi Pasteur
Flu Pandemia Vaccine Low Phase I clinical trials Pandemic influenza infection Vaccines Sanofi Pasteur
Dose
Flu Vaccine Micro-injection Phase II clinical trials Influenza infection Vaccines Sanofi Pasteur
Flublok Phase III clinical trials Influenza Vaccines Emergent BioSolutions Inc.
Gardasil Awaiting approval Cervical cancer Vaccines Merck & Co.
Gardasil Awaiting approval Cervical intraepithelial Vaccines Merck & Co.
neoplasia
Gardasil Awaiting approval Vulvar intraepithelial neoplasia Vaccines Merck & Co.
Gardasil Awaiting approval Vaginal intraepithelial Vaccines Merck & Co.
neoplasia
Gardasil Awaiting approval Genital warts Vaccines Merck & Co.
Gardasil Awaiting approval Cervical adenocarcinoma Vaccines Merck & Co.
in situ
Gardasil Awaiting approval Vaginal cancer Vaccines Merck & Co.
73
Developer/partner
developer
Gardasil Awaiting approval Vulvar cancer Vaccines Merck & Co.
GelVac Influenza Vaccine Phase I clinical trials Influenza Vaccines DelSite Biotechnologies Inc.
GeoVax AIDS Vaccine Phase I clinical trials HIV infection Vaccines GeoVax Labs Inc.
H5N1 Avian Influenza Phase I clinical trials Avian influenza Vaccines Antigen Express Inc.
Vaccine
H5N1 Influenza Vaccine Phase I clinical trials Pandemic influenza Vaccines MedImmune Inc.
H5N1 Pandemic Influenza Phase I clinical trials Pandemic influenza Vaccines Vical Inc.
Vaccine
HA-Flagellin Flu Vaccine Phase I clinical trials Influenza infection Vaccines VaxInnate Corp.
HCV Vaccine Phase I clinical trials Hepatitis C Vaccines Novartis Vaccines and
Diagnostics, CSL Behring
Hepatitis E Virus Vaccine Phase II clinical trials Hepatitis E Vaccines GlaxoSmithKline Inc.
Herpes Zoster Vaccine Phase III clinical trials Herpes zoster Vaccines Sanofi Pasteur MSD
Hexaxim Phase III clinical trials Diphtheria, tetanus, pertussis, Vaccines Sanofi Pasteur
hepatitis B, poliomyelitis and
Haemophilus influenzae b
infection
Hib-MenCY-TT Phase III clinical trials Neisseria meningitis groups Vaccines GlaxoSmithKline Inc.
C and Y disease and
Haemophilus influenzae type
b disease
HIV Vaccine Phase I clinical trials HIV infection Vaccines Crucell NV
HIV Vaccine Phase I clinical trials HIV infection Vaccines GlaxoSmithKline Inc.
Imvamune Phase II clinical trials Smallpox Vaccines Bavarian Nordic AS
Influvac TC Phase I clinical trials Influenza Vaccines Solvay Pharmaceuticals Inc.
Ixiaro Awaiting approval Japanese encephalitis Vaccines Novartis Vaccines and
Diagnostics
JVRS-100 Phase I clinical trials Influenza Vaccines Juvaris BioTherapeutics Inc.
LC16m8 Phase I/II clinical trials Smallpox Vaccines Kaketsuken
M2e Universal Influenza Phase I clinical trials Influenza Vaccines VaxInnate Corp.
Vaccine
Malaria Vaccine Phase I/II clinical trials Malaria Vaccines GenVec Inc.
Malaria Vaccine Phase I clinical trials Malaria Vaccines Crucell NV
MEDI-534 Phase I clinical trials Parainfluenza virus type 3 Vaccines MedImmune Inc.
MEDI-534 Phase I clinical trials Respiratory syncytial virus Vaccines MedImmune Inc.
MEDI-560 Phase I clinical trials Parainfluenza virus type 3 Vaccines MedImmune Inc.
MEDI-566 Phase I clinical trials Pandemic influenza Vaccines MedImmune Inc.
prevention
Menactra Toddler Phase III clinical trials Invasive meningococcal Vaccines Sanofi Pasteur
disease
MenACWY-TT Phase III clinical trials Neisseria meningitis groups A, Vaccines GlaxoSmithKline Inc.
C, W and Y diseases
MenB Phase III clinical trials Meningococcal B infection Vaccines Novartis
Meninge A,C,Y,W 2nd Phase I clinical trials Meningitis Vaccines Sanofi Pasteur
Generation
Meningococcal B Vaccine Phase II clinical trials Meningococcal disease Vaccines Wyeth Pharmaceuticals
Menveo Awaiting approval Meningococcal disease Vaccines Novartis Vaccines and
Diagnostics
Mosquirix Phase II clinical trials Malaria Vaccines GlaxoSmithKline Inc.
MVA AIDS Vaccine Phase I clinical trials HIV infection Vaccines GeoVax Labs Inc.
Needle-Free Influenza Phase II clinical trials Pandemic influenza Vaccines Intercell AG
Vaccine Patch
74
Developer/partner
developer
Needle-Free Travelers Phase II clinical trials Travelers diarrhea Vaccines Intercell AG
Diarrhea Vaccine Patch
New Generation Flu Vaccine Phase III clinical trials Seasonal influenza Vaccines GlaxoSmithKline Inc.
Norovirus Vaccine Phase I clinical trials Norovirus infection Vaccines LigoCyte
OncoVAX Phase III clinical trials Colorectal cancer Vaccines Intracel Corp.
Optaflu Phase III clinical trials Influenza Vaccines Novartis Vaccines and
Diagnostics
Oral Anthrax/Plague Phase I clinical trials Anthrax infection Vaccines Celldex Therapeutics Inc.,
Combination Vaccine DynPort Vaccine Co.
Parvovirus B19 Vaccine Phase I/II clinical trials Parvovirus Vaccines Meridian Bioscience Inc.
Pennvax-B Phase I clinical trials HIV infection Vaccines VGX Pharmaceuticals
PentaStaph Phase III clinical trials Staphylococcus aureus Vaccines Nabi Biopharmaceuticals
infection
Pneumo Vaccine Phase I clinical trials Meningitis and pneumonia Vaccines Sanofi Pasteur
Pneumococcal Vaccine Phase I clinical trials Pneumococcal infection Vaccines MedImmune Inc.
Prepandrix Phase III clinical trials Avian influenza Vaccines GlaxoSmithKline Inc.
Prevnar 13 Phase III clinical trials Pneumococcal disease Vaccines Wyeth Pharmaceuticals
Pseudomonas Vaccine Phase II clinical trials Pseudomonas infection Vaccines Intercell AG
Rabies Monoclonal Phase II clinical trials Rabies Vaccines Crucell NV, Sanofi Pasteur
Antibody Cocktail
RiVax Phase I clinical trials Ricin toxin Vaccines DOR BioPharma Inc.,
Cambrex Corp.
S. Epidermidis PS-1 Vaccine Phase I clinical trials Staphylococcus epidermidis Vaccines Nabi Biopharmaceuticals
infection
S. Pneumoniae adult Phase I clinical trials Streptococcus pneumonia Vaccines GlaxoSmithKline Inc.
Vaccine
Simplirix Phase III clinical trials Genital herpes Vaccines GlaxoSmithKline Inc.
SparVax Phase II clinical trials Anthrax infection Vaccines PharmAthene Inc.
ST-246 Phase I clinical trials Smallpox Vaccines Siga Technologies Inc.
Synflorix Phase III clinical trials Streptococcus pneumonia Vaccines GlaxoSmithKline Inc.
Thraxine Phase II clinical trials Anthrax infection Vaccines PharmAthene US Corp.
Tuberculosis Vaccine Phase II clinical trials Tuberculosis Vaccines GlaxoSmithKline Inc.
Tuberculosis Vaccine Phase I clinical trials Tuberculosis Vaccines Sanofi Pasteur
Tuberculosis Vaccine Phase I clinical trials Tuberculosis Vaccines Crucell NV
Ty800 Phase II clinical trials Typhoid fever Vaccines Celldex Therapeutics Inc.
Typhoid Vaccine Phase II clinical trials Typhoid fever Vaccines Emergent BioSolutions Inc.
Unifive Phase III clinical trials Diphtheria, tetanus, pertussis, Vaccines Sanofi Pasteur
hepatitis B, and Haemophilus
influenzae b infection
V-950 Phase I clinical trials Alzheimer’s disease Vaccines Merck & Co.
V503 Phase II clinical trials Human papillomavirus Vaccines Merck & Co.
infection
V512 Phase I clinical trials Influenza Vaccines Merck & Co.
V710 Phase II clinical trials Staphylococcus aureus Vaccines Merck & Co.
infection
Varicella Zoster Vaccine Phase II clinical trials Varicella Zoster Vaccines GlaxoSmithKline Inc.
VIR201 Phase II clinical trials HIV infection Vaccines Virax Holdings Ltd.
VLP Influenza Vaccine Phase II clinical trials Avian influenza Vaccines Novavax Inc.
VLP Influenza Vaccine Phase II clinical trials Seasonal influenza Vaccines Novavax Inc.
VRP Vaccine Phase I clinical trials Influenza Vaccines AlphaVax Inc.
West Nile Vaccine Phase I clinical trials West Nile virus infection Vaccines Hawaii Biotechnology Group
75
TOP 15 THERAPEUTIC GROUPS: GASTROINTESTINAL
Developer/partner
developer
876008 Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs GlaxoSmithKline Inc.,
962040 Phase I clinical trials Delayed gastric emptying Gastrointestinal drugs GlaxoSmithKline Inc.
AB-1001 Phase III clinical trials Chemotherapy-induced Gastrointestinal drugs Abeille Pharmaceuticals Inc.
nausea and vomiting
ABT-874 Phase II clinical trials Crohn’s disease Gastrointestinal drugs Abbott Laboratories
AcipHex Phase II clinical trials Gastroesophageal reflux Gastrointestinal drugs Eisai Inc.
disease
AcipHex Extended-Release Phase I clinical trials Gastrointestinal disorder Gastrointestinal drugs Eisai Inc.
AcipHex Long-Acting Phase III clinical trials Gastrointestinal disorder Gastrointestinal drugs Eisai Inc.
Alequel Phase II clinical trials Crohn’s disease Gastrointestinal drugs Enzo Biochem Inc.
Alicaforsen Phase III clinical trials Ulcerative colitis Gastrointestinal drugs Atlantic Healthcare Ltd.
Alicaforsen Phase III clinical trials Pouchitis Gastrointestinal drugs Atlantic Healthcare Ltd.
Alinia Tablet Phase II clinical trials Crohn’s disease Gastrointestinal drugs Romark Laboratories LC
Amitiza Phase III clinical trials Opioid bowel dysfunction Gastrointestinal drugs Sucampo
Anti-Beta 7 Phase I clinical trials Inflammatory bowel disease Gastrointestinal drugs Genentech Inc.
APF530 Phase III clinical trials Chemotherapy-induced Gastrointestinal drugs A.P. Pharma Inc.
nausea and vomiting
Apilimod Phase II clinical trials Crohn’s disease Gastrointestinal drugs Synta Pharmaceuticals Corp.
Asimadoline Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Tioga Pharmaceuticals Inc.
ASP1002 Phase I clinical trials Crohn’s disease Gastrointestinal drugs Asphelia Pharmaceuticals Inc.
AST-120 Phase III clinical trials Crohn’s disease Gastrointestinal drugs Ocera Therapeutics Inc.
AST-120 Phase II clinical trials Pouchitis Gastrointestinal drugs Ocera Therapeutics Inc.
AT-1001 Phase I clinical trials Crohn’s disease Gastrointestinal drugs Alba Therapeutics Corp.
AT-1001 Phase I clinical trials Irritable bowel syndrome Gastrointestinal drugs Alba Therapeutics Corp.
ATI-7505 Phase II clinical trials Gastrointestinal disorders Gastrointestinal drugs Aryx Therapeutics Inc.
ATI-7505 Phase II clinical trials Constipation Gastrointestinal drugs Aryx Therapeutics Inc.
ATI-7505 Phase II clinical trials Dyspepsia Gastrointestinal drugs Aryx Therapeutics Inc.
AZD1386 Phase I clinical trials Gastroesophageal reflux Gastrointestinal drugs AstraZeneca
disease Pharmaceuticals LP
AZD2066 Phase I clinical trials Gastroesophageal reflux Gastrointestinal drugs AstraZeneca
AZD3355 Phase II clinical trials Gastroesophageal reflux Gastrointestinal drugs AstraZeneca
CCX025 Phase I clinical trials Crohn’s disease Gastrointestinal drugs ChemoCentryx Inc.
Colal-Pred Phase II clinical trials Ulcerative colitis Gastrointestinal drugs Prometheus Laboratories Inc.
CP-690550 Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Pfizer Inc.
Creon Awaiting approval Pancreatic insufficiency Gastrointestinal drugs Solvay Pharmaceuticals Inc.
CRO-HIV Phase III clinical trials AIDS diarrhea Gastrointestinal drugs Napo Pharmaceuticals Inc.
CRO-IBS Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Napo Pharmaceuticals Inc.
CRO-ID Phase II clinical trials Acute infectious diarrhea Gastrointestinal drugs Napo Pharmaceuticals Inc.
CRO-PED Phase I clinical trials Pediatric diarrhea Gastrointestinal drugs Napo Pharmaceuticals Inc.
Crofelemer Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Trine Pharmaceuticals Inc.
DDP225 Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Dynogen
DDP733 Phase I clinical trials Nocturnal gastroesophageal Gastrointestinal drugs Dynogen
reflux disease Pharmaceuticals Inc.
DDP733 Phase II clinical trials Constipation-predominant Gastrointestinal drugs Dynogen
irritable bowel syndrome Pharmaceuticals Inc.
Dexloxiglumide Phase III clinical trials Irritable bowel syndrome Gastrointestinal drugs Rottapharm Madaus
76
Developer/partner
developer
Dextofisopam Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Pharmos Corp.
E3210 Phase I clinical trials Irritable bowel syndrome Gastrointestinal drugs Eisai Inc.
E3710 Phase I clinical trials Acid related disease Gastrointestinal drugs Eisai Inc.
EGS21 Phase II clinical trials Crohn’s disease Gastrointestinal drugs Enzo Therapeutics Inc.
Entereg Phase III clinical trials Opiate-induced bowel Gastrointestinal drugs Adolor Corp.
dysfunction and constipation
Gattex Phase III clinical trials Short bowel syndrome Gastrointestinal drugs NPS Pharmaceuticals Inc.
Gattex Phase II clinical trials Crohn’s disease Gastrointestinal drugs NPS Pharmaceuticals Inc.
Giazo Awaiting approval Ulcerative colitis Gastrointestinal drugs Salix Pharmaceuticals Ltd.
GL1001 Phase I clinical trials Inflammatory bowel disease Gastrointestinal drugs Ore Pharmaceuticals Inc.
GM-611 Phase II clinical trials Diabetic gastroparesis Gastrointestinal drugs Chugai Pharmaceutical Co.
GM-611 Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Chugai Pharmaceutical Co.
Guanilib Phase I clinical trials Constipation Gastrointestinal drugs Callisto Pharmaceuticals Inc.
Guanilib Phase I clinical trials Irritable bowel syndrome Gastrointestinal drugs Callisto Pharmaceuticals Inc.
HMPL-004 Phase II clinical trials Crohn’s disease Gastrointestinal drugs Hutchison China Meditech
Ltd. (Chi-Med)
HMPL-004 Phase II clinical trials Ulcerative colitis Gastrointestinal drugs Hutchison China Meditech
Ltd. (Chi-Med)
HPN-100 Phase I/II clinical trials Urea cycle disorders Gastrointestinal drugs Hyperion Therapeutics Inc.
Humira Phase III clinical trials Ulcerative colitis Gastrointestinal drugs Abbott Laboratories
Ipamorelin Phase I/II clinical trials Postoperative ileus Gastrointestinal drugs Sapphire Therapeutics Inc.
IY-81149 Phase II clinical trials Acid related diseases Gastrointestinal drugs Takeda Pharmaceuticals
North America Inc.
Laquinimod Phase II clinical trials Crohn’s disease Gastrointestinal drugs Teva Pharmaceuticals
USA Inc.
Lialda Phase III clinical trials Diverticulitis Gastrointestinal drugs Shire US Inc.
Lialda Phase III clinical trials Ulcerative colitis Gastrointestinal drugs Shire US Inc.
Linaclotide Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs Ironwood Pharmaceuticals
Inc., Forest Laboratories Inc.
Linaclotide Phase III clinical trials Chronic idiopathic Gastrointestinal drugs Ironwood Pharmaceuticals
constipation Inc., Forest Laboratories Inc.
Lipoxin Phase I clinical trials Inflammatory bowel disease Gastrointestinal drugs Bayer HealthCare
LX1031 Phase I clinical trials Irritable bowel syndrome Gastrointestinal drugs Lexicon Pharmaceuticals Inc.
M40403 Phase II clinical trials Postoperative ileus Gastrointestinal drugs ActivBiotics Inc.
MDX-1100 Phase II clinical trials Ulcerative colitis Gastrointestinal drugs Medarex Inc.
Metoclopramide-Zydis Phase III clinical trials Gastroesophageal reflux Gastrointestinal drugs Salix Pharmaceuticals Ltd.
disease
mGluRs Phase I clinical trials Gastrointestinal disease Gastrointestinal drugs NPS Pharmaceuticals Inc.
MGX-006 Phase II clinical trials Nausea and vomiting Gastrointestinal drugs Victory Pharma Inc.
MLN0002 Phase II clinical trials Ulcerative colitis Gastrointestinal drugs Millennium: The Takeda
Oncology Company
MLN0002 Phase II clinical trials Crohn’s disease Gastrointestinal drugs Millennium: The Takeda
Oncology Company
MLN0415 Phase I clinical trials Irritable bowel syndrome Gastrointestinal drugs Millennium: The Takeda
Oncology Company,
Sanofi-Aventis
Nexium Awaiting approval Peptic ulcer bleeding Gastrointestinal drugs AstraZeneca
Pharmaceuticals LP
Nexium Phase II clinical trials Extra-oesophageal reflux Gastrointestinal drugs AstraZeneca
Nexium I.V. Awaiting approval Peptic ulcer bleeding Gastrointestinal drugs AstraZeneca
Pharmaceuticals LP
77
Developer/partner
developer
Nexium Low Dose Aspirin Phase III clinical trials Peptic ulcer bleeding Gastrointestinal drugs AstraZeneca
Combination Pharmaceuticals LP
NKTR-118 Phase II clinical trials Opioid bowel dysfunction Gastrointestinal drugs Nektar Therapeutics
NU206 Phase I clinical trials Inflammatory bowel disease Gastrointestinal drugs Nuvelo Inc.,
PA32540 Phase II clinical trials Gastrointestinal side effects Gastrointestinal drugs Pozen Inc.
PF-2391677 Phase I clinical trials Gastroesophageal reflux Gastrointestinal drugs Pfizer Inc.
disease
PF-4548043 Phase I clinical trials Gastroesophageal reflux Gastrointestinal drugs Pfizer Inc.
disease
PF-885706 Phase II clinical trials Gastroesophageal reflux Gastrointestinal drugs Pfizer Inc.
disease
Prochymal Phase III clinical trials Crohn’s disease Gastrointestinal drugs Osiris Therapeutics Inc.
Protonix Granules Phase III clinical trials Gastroesophageal reflux Gastrointestinal drugs Wyeth Pharmaceuticals
disease
Protonix I.V. Phase III clinical trials Gastroesophageal reflux Gastrointestinal drugs Wyeth Pharmaceuticals
disease
Protonix Tablet Phase III clinical trials Gastroesophageal reflux Gastrointestinal drugs Wyeth Pharmaceuticals
disease
Prulifloxacin Phase III clinical trials Travelers diarrhea Gastrointestinal drugs Optimer Pharmaceuticals Inc.
Relistor Phase III clinical trials Opioid-induced constipation Gastrointestinal drugs Progenics Pharmaceuticals
Inc., Wyeth Pharmaceuticals
Relistor Phase III clinical trials Postoperative ileus Gastrointestinal drugs Progenics Pharmaceuticals
Relistor Oral Phase II clinical trials Opioid-induced constipation Gastrointestinal drugs Progenics Pharmaceuticals
Remicade Phase III clinical trials Ulcerative colitis Gastrointestinal drugs Centocor Inc.
Reslizumab Phase II/III clinical trials Eosinophilic esophagitis Gastrointestinal drugs Ception Therapeutics Inc.
Rezonic Awaiting approval Postoperative nausea and Gastrointestinal drugs GlaxoSmithKline Inc.
vomiting
Rezonic Awaiting approval Chemotherapy-induced Gastrointestinal drugs GlaxoSmithKline Inc.
nausea and vomiting
Rezular Phase III clinical trials Irritable bowel syndrome Gastrointestinal drugs AGI Therapeutics Plc.
rhuMAb Beta7 Phase I clinical trials Ulcerative colitis Gastrointestinal drugs Genentech Inc.
Rifamycin SV MMX Phase III clinical trials Diarrhea Gastrointestinal drugs Cosmo Pharmaceuticals
Rolapitant Phase II clinical trials Emesis Gastrointestinal drugs Schering-Plough Corp.
Simulect Phase II clinical trials Ulcerative colitis Gastrointestinal drugs Cerimon Pharmaceuticals Inc.
SLV339 Phase II clinical trials Pancreatic insufficiency Gastrointestinal drugs Solvay Pharmaceuticals Inc.
Solabegron Phase II clinical trials Irritable bowel syndrome Gastrointestinal drugs GlaxoSmithKline Inc.
SP-304 Phase I clinical trials Constipation Gastrointestinal drugs Synergy Pharmaceuticals Inc.
TAK-390MR Awaiting approval Erosive esophagitis Gastrointestinal drugs Takeda Pharmaceuticals
North America Inc.
TAK-390MR Awaiting approval Non-erosive Gastrointestinal drugs Takeda Pharmaceuticals
gastroesophageal reflux North America Inc.
disease
TD-5108 Phase II clinical trials Gastrointestinal disorder Gastrointestinal drugs Theravance Inc.
Traficet-EN Phase II/III clinical trials Crohn’s disease Gastrointestinal drugs GlaxoSmithKline Inc.
Triolex Phase I/II clinical trials Ulcerative colitis Gastrointestinal drugs Hollis-Eden
TZP-101 Phase II clinical trials Postoperative ileus Gastrointestinal drugs Tranzyme Pharma
TZP-101 Phase II clinical trials Gastroparesis Gastrointestinal drugs Tranzyme Pharma
TZP-102 Phase I clinical trials Gastroparesis Gastrointestinal drugs Tranzyme Pharma
Xifaxan Phase III clinical trials Travelers diarrhea Gastrointestinal drugs Salix Pharmaceuticals Ltd.
Xifaxan Phase III clinical trials Irritable bowel syndrome Gastrointestinal drugs Salix Pharmaceuticals Ltd.
78
Developer/partner
developer
Xifaxan Phase III clinical trials Non-constipation irritable Gastrointestinal drugs Salix Pharmaceuticals Ltd.
bowel syndrome
XP19986 Phase II clinical trials Gastroesophageal reflux Gastrointestinal drugs XenoPort Inc.
disease
YM443 Phase II clinical trials Functional dyspepsia Gastrointestinal drugs Astellas Pharma US Inc.
Zegerid OTC Awaiting approval Heartburn Gastrointestinal drugs Schering-Plough HealthCare
Products Inc.
ZP1846 Phase I clinical trials Diarrhea Gastrointestinal drugs Zealand Pharma AS
79
TOP 15 THERAPEUTIC GROUPS: OPHTHALMOLOGY
Developer/partner
developer
ACU-02 Phase I clinical trials Dry eye Ophthalmology Acucela Inc.
ACU-4429 Phase I clinical trials Age-related macular Ophthalmology Acucela Inc.,
degeneration Otsuka America
Pharmaceutical Inc.
Acular X Phase III clinical trials Inflammation Ophthalmology Allergan Inc.
AdPEDF Phase I clinical trials Age-related macular Ophthalmology GenVec Inc.
degeneration
AL-37807 Phase II clinical trials Glaucoma Ophthalmology Alcon Laboratories Inc.
AL-43546 Phase II clinical trials Dry eye Ophthalmology Alcon Laboratories Inc.
Androgen Tear Phase II clinical trials Dry eye Ophthalmology Allergan Inc.
Anecortave Acetate Phase II/III clinical trials Glaucoma Ophthalmology Alcon Laboratories Inc.
ARG101 Phase I/II clinical trials Dry eye Ophthalmology arGentis Pharmaceuticals Inc.
ARG102 Phase I/II clinical trials Dry eye Ophthalmology arGentis Pharmaceuticals Inc.
Arxxant Awaiting approval Diabetic retinopathy Ophthalmology Eli Lilly and Co.
Atacand Phase III clinical trials Diabetic retinopathy Ophthalmology AstraZeneca
Pharmaceuticals LP
ATG003 Phase II clinical trials Neovascular age-related Ophthalmology CoMentis Inc.
macular degeneration
AzaSite Plus Phase III clinical trials Eye inflammation Ophthalmology Insite Vision Inc.
AzaSite Plus Phase III clinical trials Eye infections Ophthalmology Insite Vision Inc.
AzaSite Plus Phase III clinical trials Blepharoconjunctivitis Ophthalmology Insite Vision Inc.
B27PD Phase II clinical trials Uveitis Ophthalmology Enzo Therapeutics Inc.
Bepreve Phase III clinical trials Allergic conjunctivitis Ophthalmology Ista Pharmaceuticals Inc.
Bevasiranib Phase III clinical trials Wet age-related macular Ophthalmology Opko Health Inc.
degeneration
Bevasiranib Phase III clinical trials Diabetic macular edema Ophthalmology Opko Health Inc.
C-KAD Ophthalmic Solution Phase I/II clinical trials Cataracts Ophthalmology Chakshu Research
C-KAD Ophthalmic Solution Phase I/II clinical trials Glaucoma Ophthalmology Chakshu Research
Catena Phase II clinical trials Leber hereditary optic Ophthalmology Santhera
neuropathy Pharmaceuticals AG
CF101 Phase II clinical trials Dry eye Ophthalmology Can-Fite BioPharma Ltd.
Cortiject Phase I clinical trials Diabetic macular edema Ophthalmology Novagali Pharma
Cyclosporine Phase III clinical trials Dry eye Ophthalmology Sirion Therapeutics Inc.
Cystoran Phase III clinical trials Ocular crystals Ophthalmology Sigma-Tau
DE-101 Phase II clinical trials Corneal and conjunctival Ophthalmology Santen Inc.
epithelial disorder
DE-104 Phase II clinical trials Glaucoma Ophthalmology Santen Inc.
DE-104 Phase II clinical trials Ocular hypertension Ophthalmology Santen Inc.
DNB-001 Phase II clinical trials Ocular hypertension Ophthalmology Danube Pharmaceuticals Inc.
Doxovir Phase II clinical trials Conjunctivitis Ophthalmology Opko Health Inc.
DR Cysteamine Phase II clinical trials Cystinosis Ophthalmology Bennu Pharmaceuticals Inc.
Durezol Phase III clinical trials Anterior uveitis Ophthalmology Sirion Therapeutics Inc.
E10030 Phase I clinical trials Age-related macular Ophthalmology Ophthotech Corp.
degeneration
Ecabet Sodium Phase II clinical trials Dry eye Ophthalmology Ista Pharmaceuticals Inc.
Fenretinide Phase II clinical trials Geographic atrophy Ophthalmology Sirion Therapeutics Inc.
Ganciclovir Gel Phase III clinical trials Keratitis Ophthalmology Sirion Therapeutics Inc.
I-vation TA Phase I clinical trials Ophthalmic diseases Ophthalmology Merck & Co.
IBI-20089 Phase I clinical trials Cystoid macular edema Ophthalmology Icon Bioscience Inc.
iCo-007 Phase I clinical trials Eye diseases Ophthalmology iCo Therapeutics Inc.
80
Developer/partner
developer
iCo-007 Phase I clinical trials Diabetic macular edema Ophthalmology iCo Therapeutics Inc.
iDESTRIN Phase II clinical trials Dry eye Ophthalmology Nascent Pharmaceuticals Inc.
Iluvien Phase III clinical trials Diabetic macular edema Ophthalmology Alimera Sciences Inc.,
pSivida Ltd.
INO-8875 Phase I clinical trials Glaucoma Ophthalmology Inotek Pharmaceuticals Corp.
INS117548 Phase I clinical trials Glaucoma Ophthalmology Inspire Pharmaceuticals Inc.
IOP Lowering Phase I clinical trials Glaucoma Ophthalmology Allergan Inc.
ISV-205 Phase II clinical trials Ocular inflammation Ophthalmology Insite Vision Inc.
ISV-205 Phase II clinical trials Glaucoma Ophthalmology InSite Vision Inc.
ISV-403 Phase III clinical trials Ocular infection Ophthalmology Bausch & Lomb Inc.
JSM 6427 Phase I clinical trials Age-related macular Ophthalmology Jerini Ophthalmic Inc.,
degeneration PR Pharmaceuticals Inc.
Lantus Awaiting approval Retinopathy Ophthalmology Sanofi-Aventis
LFA-1 inhibitor Phase I clinical trials T-cell mediated ophthalmic Ophthalmology SARcode Corp.
diseases
Lucentis Phase III clinical trials Diabetic macular edema Ophthalmology Genentech Inc.,
Novartis Ophthalmics Inc.
Lucentis Phase III clinical trials Retinal vein occlusion Ophthalmology Genentech Inc.,
Novartis Ophthalmics Inc.
Lumigan X Awaiting approval Glaucoma Ophthalmology Allergan Inc.
Lumigan/Timolol Awaiting approval Glaucoma Ophthalmology Allergan Inc.
Combination
Luveniq Phase III clinical trials Uveitis Ophthalmology Lux Biosciences Inc.
LX201 Phase III clinical trials Corneal transplant rejection Ophthalmology Lux Biosciences Inc.
Memantine Oral Phase III clinical trials Glaucoma Ophthalmology Allergan Inc.
Microplasmin Phase II clinical trials Posterior vitreous detachment Ophthalmology ThromboGenics Ltd.
Microplasmin Phase II clinical trials Diabetic macular edema Ophthalmology ThromboGenics Ltd.
MK-0140 Phase II clinical trials Ophthalmic conditions Ophthalmology Merck & Co.
MM-093 Phase II clinical trials Uveitis Ophthalmology Merrimack
Moxifloxacin Phase III clinical trials Eye infections Ophthalmology Alcon Laboratories Inc.
Moxifloxacin/ Phase III clinical trials Eye inflammation Ophthalmology Alcon Laboratories Inc.
Dexamethasone
Combination
Moxifloxacin/ Phase III clinical trials Eye infections Ophthalmology Alcon Laboratories Inc.
Dexamethasone
Combination
Nova22007 Phase III clinical trials Dry eye Ophthalmology Novagali Pharma
NT-501 Phase II/III clinical trials Retinal diseases Ophthalmology Neurotech USA Inc.
NT-501 Phase II clinical trials Age-related macular Ophthalmology Neurotech USA Inc.
degeneration
OMS302 Phase I/II clinical trials Ophthalmic conditions Ophthalmology Omeros Corp.
OT-551 Phase II clinical trials Cataracts Ophthalmology Othera Pharmaceuticals Inc.
OT-551 Phase I clinical trials Wet age-related macular Ophthalmology Othera Pharmaceuticals Inc.
degeneration
OT-551 Phase II clinical trials Geographic atrophy Ophthalmology Othera Pharmaceuticals Inc.
OT-730 Phase I/II clinical trials Glaucoma Ophthalmology Othera Pharmaceuticals Inc.
OT-730 Phase I/II clinical trials Ocular hypertension Ophthalmology Othera Pharmaceuticals Inc.
Pazopanib Phase I clinical trials Age-related macular Ophthalmology GlaxoSmithKline Inc.
degeneration
PF-3187207 Phase II clinical trials Glaucoma Ophthalmology Pfizer Inc.
PF-4217329 Phase II clinical trials Glaucoma Ophthalmology Pfizer Inc.
81
Developer/partner
developer
PF-4523655 Phase II clinical trials Age-related macular Ophthalmology Pfizer Inc.
degeneration
PF-4523655 Phase II clinical trials Diabetic macular edema Ophthalmology Pfizer Inc.
PG-11047 Phase I clinical trials Age-related macular Ophthalmology Progen Pharmaceuticals Inc.
degeneration
Posurdex Phase III clinical trials Retinal vein occlusion Ophthalmology Allergan Inc.
Posurdex Phase III clinical trials Diabetic macular edema Ophthalmology Allergan Inc.
POT-4 Phase I clinical trials Age-related macular Ophthalmology Potentia Pharmaceuticals Inc.
degeneration
Prolacria Awaiting approval Dry eye Ophthalmology Inspire Pharmaceuticals Inc.,
Allergan Inc.
Rebamipide Phase III clinical trials Dry eye Ophthalmology Otsuka Pharmaceutical
Development &
Commercialization Inc.,
Acucela Inc.
RGN-259 Phase II clinical trials Diabetic vitrectomy Ophthalmology RegeneRx
RKI983 Phase I clinical trials Glaucoma Ophthalmology Novartis Pharmaceuticals
Corp.
Simulect Phase II clinical trials Uveitis Ophthalmology Cerimon Pharmaceuticals Inc.
Sirna-027/ AGN-745 Phase II clinical trials Age-related macular Ophthalmology Merck & Co.,
degeneration Allergan Inc.
Sirolimus Phase II clinical trials Diabetic macular edema Ophthalmology MacuSight Inc.
Sirolimus Phase I clinical trials Wet age-related macular Ophthalmology MacuSight Inc.
degeneration
T-Pred Awaiting approval Eye inflammation Ophthalmology Ista Pharmaceuticals Inc.
Taflotan Phase III clinical trials Glaucoma Ophthalmology Santen Inc.
Taflotan Phase III clinical trials Ocular hypertension Ophthalmology Santen Inc.
TG100801 Phase II clinical trials Wet age-related macular Ophthalmology TargeGen Inc.
degeneration
TobraDex ST Awaiting approval Eye inflammation Ophthalmology Alcon Laboratories Inc.
Trivaris Phase III clinical trials Diabetic retinopathy Ophthalmology Allergan Inc.
Trivaris Phase III clinical trials Retinal vein occlusion Ophthalmology Allergan Inc.
VEGF Trap-Eye Phase III clinical trials Wet age-related macular Ophthalmology Regeneron Pharmaceuticals
degeneration Inc., Bayer HealthCare
VEGF Trap-Eye Phase I clinical trials Diabetic macular edema Ophthalmology Regeneron Pharmaceuticals
Vekacia Phase III clinical trials Vernal keratoconjunctivitis Ophthalmology Novagali Pharma
Vismed Phase III clinical trials Dry eye Ophthalmology Lantibio Inc.
Visudyne/Anti-VEGF- Phase II clinical trials Age-related macular Ophthalmology QLT Inc., Novartis
Dexamethasone degeneration Pharmaceuticals Corp.
Combitation
Vitreosolve Phase III clinical trials Diabetic retinopathy Ophthalmology Vitreoretinal Technologies Inc.
Xibrom QD Awaiting approval Postoperative ocular pain Ophthalmology Ista Pharmaceuticals Inc.
Xibrom QD Awaiting approval Postoperative ocular Ophthalmology Ista Pharmaceuticals Inc.
inflammation
Zybrestat Phase II clinical trials Myopic macular Ophthalmology Oxigene Inc.
degeneration
Zymar X Phase III clinical trials Ocular infection Ophthalmology Allergan Inc.,
Kyorin Co.
82
TOP 15 THERAPEUTIC GROUPS: ARTHRITIS
Developer/partner
developer
1827771 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents GlaxoSmithKline Inc.
274150 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents GlaxoSmithKline Inc.
2nd Generation Anti-CD20 Phase III clinical trials Rheumatoid arthritis Anti-arthritic agents Biogen Idec Inc., Genentech
Inc., Hoffmann-La Roche Inc.
315234 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents GlaxoSmithKline Inc.
Actemra Awaiting approval Rheumatoid arthritis Anti-arthritic agents Chugai Pharmaceutical Co.,
Actemra Phase III clinical trials Systemic-onset juvenile Anti-arthritic agents Chugai Pharmaceutical Co.,
idiopathic arthritis Hoffmann-La Roche Inc.
AIN457 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Novartis
AMG 108 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Amgen Inc.
AMG 827 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Amgen Inc.
Apilimod Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Synta Pharmaceuticals Corp.
Apremilast Phase II clinical trials Psoriatic arthritis Anti-arthritic agents Celgene Corp.
Arcoxia Awaiting approval Rheumatoid arthritis Anti-arthritic agents Merck & Co.
ARRY-162 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Array BioPharma Inc.
Atacicept Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Merck Serono SA
AZD5672 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents AstraZeneca
Pharmaceuticals LP
AZD9056 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents AstraZeneca
Pharmaceuticals LP
CAM-3001 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents MedImmune Inc.
Canakinumab Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Novartis Pharmaceuticals
Corp.
Canakinumab Phase II clinical trials Juvenile idiopathic arthritis Anti-arthritic agents Novartis Pharmaceuticals
Corp.
CC-10015 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Celgene Corp.
CCX354 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents ChemoCentryx Inc.
CE-224535 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Pfizer Inc.
CE-224535 Phase II clinical trials Osteoarthritis Anti-arthritic agents Pfizer Inc.
Celebrex Phase III clinical trials Gouty arthritis Anti-arthritic agents Pfizer Inc.
CF101 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Can-Fite BioPharma Ltd.
CH-1504 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Chelsea Therapeutics Inc.
Cimzia Awaiting approval Rheumatoid arthritis Anti-arthritic agents UCB Pharma Inc.
CNTO 148 I.V. Phase III clinical trials Rheumatoid arthritis Anti-arthritic agents Centocor Inc.
Schering-Plough Corp.
CP-690550 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Pfizer Inc.
Denosumab Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Amgen Inc.
Diractin Phase III clinical trials Osteoarthritis Anti-arthritic agents Alpharma Inc.
Fibroblast growth factor-18 Phase I clinical trials Osteoarthritis Anti-arthritic agents EMD Serono Inc.
Golimumab Awaiting approval Rheumatoid arthritis Anti-arthritic agents Centocor Inc.,
Golimumab Awaiting approval Ankylosing spondylitis Anti-arthritic agents Centocor Inc.,
Golimumab Awaiting approval Psoriatic arthritis Anti-arthritic agents Centocor Inc.,
IL-1 Beta Antibody Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Eli Lilly and Co.
IL-6R Antibody Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Sanofi-Aventis, Regeneron
83
Developer/partner
developer
ILV-094 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Wyeth Pharmaceuticals
INCB18424 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Incyte Corp.
KB002 Phase I/II clinical trials Rheumatoid arthritis Anti-arthritic agents KaloBios Pharmaceuticals Inc.
KB003 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents KaloBios Pharmaceuticals Inc.
LX2931 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Lexicon Pharmaceuticals Inc.
MDX-1100 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Medarex Inc.
MDX-1342 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Medarex Inc.
MLN0415/ SAR479746 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Millennium: The Takeda
Oncology Company,
Sanofi-Aventis
MLN3701/ AVE1701 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Millennium: The Takeda
Oncology Company,
Sanofi-Aventis
MLN3897/ AVE9897 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Millennium: The Takeda
Oncology Company,
Sanofi-Aventis
MM-093 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Merrimack
Monovisc Phase I clinical trials Osteoarthritis Anti-arthritic agents Anika Therapeutics Inc.
Naproxcinod Phase III clinical trials Osteoarthritis Anti-arthritic agents NicOx Inc.
Ofatumumab Phase III clinical trials Rheumatoid arthritis Anti-arthritic agents Genmab Inc.,
Ofatumumab Subcutaneous Phase I/II clinical trials Rheumatoid arthritis Anti-arthritic agents Genmab Inc.,
Otelixizumab Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Tolerx Inc.
p38 Kinase Inhibitor Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Bristol-Myers Squibb Co.
Panzem Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents EntreMed Inc.
Paxceed Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Angiotech
PD-360324 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Pfizer Inc.
Pennsaid Awaiting approval Osteoarthritis Anti-arthritic agents Nuvo Research Inc.
PF-251802 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Pfizer Inc.
PH-797804 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Pfizer Inc.
PMI-001 Phase III clinical trials Rheumatoid arthritis Anti-arthritic agents Phytomedics Inc.
PN400 Phase III clinical trials Osteoarthritis Anti-arthritic agents Pozen Inc., AstraZeneca
Pharmaceuticals LP
PN400 Phase III clinical trials Rheumatoid arthritis Anti-arthritic agents Pozen Inc., AstraZeneca
Pharmaceuticals LP
PN400 Phase III clinical trials Ankylosing spondylitis Anti-arthritic agents Pozen Inc., AstraZeneca
Pharmaceuticals LP
Prexige Awaiting approval Osteoarthritis Anti-arthritic agents Novartis
PRTX-100 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Protalex Inc.
R348 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Rigel Pharmaceuticals Inc.
R7277 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Hoffmann-La Roche Inc.
R788 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Rigel Pharmaceuticals Inc.
Rituxan Phase III clinical trials Rheumatoid arthritis Anti-arthritic agents Biogen Idec Inc., Genentech
SAR153191 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Sanofi-Aventis
SBI-087 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Wyeth Pharmaceuticals,
Trubion Pharmaceuticals Inc.
84
Developer/partner
developer
SC-84250 Phase II clinical trials Osteoarthritis Anti-arthritic agents Pfizer Inc.
SC12267 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents EMD Serono Inc.
SMC021 Phase III clinical trials Osteoarthritis Anti-arthritic agents Novartis
SSR150106 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Sanofi-Aventis
Synavive Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents CombinatoRx Inc.
Synavive Phase II clinical trials Osteoarthritis Anti-arthritic agents CombinatoRx Inc.
Synvisc-One Awaiting approval Osteoarthritis Anti-arthritic agents Genzyme Biosurgery
TAK-783 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Takeda Pharmaceuticals
North America Inc.
TgAAC94 Phase I/II clinical trials Rheumatoid arthritis Anti-arthritic agents Targeted Genetics Corp.
ThermoProfen Phase III clinical trials Osteoarthritis Anti-arthritic agents Zars Pharma
Triolex Phase I/II clinical trials Rheumatoid arthritis Anti-arthritic agents Hollis-Eden
TRU-015 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Wyeth Pharmaceuticals,
Trubion Pharmaceuticals Inc.
VEL-0230 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents Velcura Therapeutics Inc.
VGX-1027 Phase I clinical trials Rheumatoid arthritis Anti-arthritic agents VGX Pharmaceuticals
VX-702 Phase II clinical trials Rheumatoid arthritis Anti-arthritic agents Vertex Pharmaceuticals Inc.
85
TOP 15 THERAPEUTIC GROUPS: HEMATOLOGY
Developer/partner
developer
6R-BH4 Phase II clinical trials Sickle cell disease Blood-disorder treatments BioMarin Pharmaceutical Inc.
Ad2/HIF-1a Phase II clinical trials Intermittent claudication Intermittent claudication Genzyme Corp.
drugs
AKR-501 Phase II clinical trials Idiopathic thrombocytopenia Blood-disorder treatments MGI Pharma Inc.
purpura
Angiomax Phase III clinical trials Coronary artery bypass graft Blood-disorder treatments The Medicines Co.
surgery
APD791 Phase I clinical trials Arterial thrombosis Blood-disorder treatments Arena Pharmaceuticals Inc.
Apixaban Phase III clinical trials Venous thromboembolism Blood-disorder treatments Bristol-Myers Squibb Co.,
Pfizer Inc.
Aranesp Phase III clinical trials Anemia Blood-disorder treatments Amgen Inc.
ARC1779 Phase II clinical trials Thrombotic Blood-disorder treatments Archemix Corp.
thrombocytopenic purpura
ART-123 Phase II clinical trials Disseminated intravascular Blood-disorder treatments Artisan Pharma Inc.
coagulation
ATI-5923 Phase II/III clinical trials Deep-vein thrombosis Blood-disorder treatments Aryx Therapeutics Inc.
ATryn Awaiting approval Hereditary antithrombin Blood-disorder treatments Ovation Pharmaceuticals Inc.
deficiency
AVE5026 Phase III clinical trials Venous thromboembolism Blood-disorder treatments Sanofi-Aventis
AZD0837 Phase III clinical trials Thrombosis Blood-disorder treatments AstraZeneca
Pharmaceuticals LP
AZD6140 Phase III clinical trials Arterial thrombosis Blood-disorder treatments AstraZeneca
Pharmaceuticals LP
AZD6482 Phase I clinical trials Thrombosis Blood-disorder treatments AstraZeneca
Pharmaceuticals LP
Betrixaban Phase II clinical trials Venous thromboembolism Blood-disorder treatments Portola Pharmaceuticals Inc.
Cangrelor Phase III clinical trials Arterial thrombosis Blood-disorder treatments The Medicines Co.
CGT-2168 Phase III clinical trials Gastrointestinal bleeding Blood-disorder treatments Cogentus
Dabigatran Phase III clinical trials Deep-vein thrombosis Blood-disorder treatments Boehringer Ingelheim
Defibrotide Phase III clinical trials Severe hepatic venous Blood-disorder treatments Gentium S.p.A.
occlusive disease
Defibrotide Phase III clinical trials Veno-occlusive disease Blood-disorder treatments Gentium S.p.A.
DG041 Phase II clinical trials Arterial thrombosis Blood-disorder treatments deCode Genetics Inc.
DU-176b Phase II clinical trials Venous thromboembolism Blood-disorder treatments Daiichi Sankyo Inc.
DU-176b Phase II clinical trials Non-valvular atrial fibrillation Blood-disorder treatments Daiichi Sankyo Inc.
Factor IXFc Phase I/II clinical trials Hemophilia B Blood-disorder treatments Biovitrum AB
Factor Xa Inhibitor Phase II clinical trials Thrombotic disorders Blood-disorder treatments Eli Lilly and Co.
FC Receptor Antagonist Phase I clinical trials Idiopathic thrombocytopenia Blood-disorder treatments Genzyme Corp.
purpura
Ferumoxytol Awaiting approval Iron deficiency anemia Blood-disorder treatments AMAG Pharmaceuticals Inc.
FG-2216 Phase II clinical trials Renal anemia Blood-disorder treatments FibroGen Inc.
FG-4592 Phase II clinical trials Anemia Blood-disorder treatments FibroGen Inc.
Flovagatran Phase III clinical trials Anticoagulant Blood-disorder treatments Paion AG
GMI-1070 Phase I clinical trials Sickle cell disease Blood-disorder treatments GlycoMimetics Inc.
Hematide Phase III clinical trials Anemia Blood-disorder treatments Affymax Inc.,
North America Inc.
Hemopure Phase III clinical trials Red blood cell transfusion Blood-disorder treatments Biopure Corp.
reduction
Hemopure Phase II clinical trials Aortic aneurysm Blood-disorder treatments Biopure Corp.
reconstruction surgery
Hemospan Phase II clinical trials Blood substitute Blood-disorder treatments Sangart Inc.
86
Developer/partner
developer
HemoTech Phase I clinical trials Blood substitute Blood-disorder treatments HemoBioTech Inc.
Human Fibrinogen Awaiting approval Congenital fibrinogen Blood-disorder treatments CSL Behring
Concentrate deficiency
Idrabiotaparinux Phase III clinical trials Deep-vein thrombosis Blood-disorder treatments Sanofi-Aventis
Idrabiotaparinux Phase III clinical trials Pulmonary embolism Blood-disorder treatments Sanofi-Aventis
Idraparinux Phase III clinical trials Deep-vein thrombosis Blood-disorder treatments Sanofi-Aventis
Idraparinux Phase III clinical trials Pulmonary embolism Blood-disorder treatments Sanofi-Aventis
INDI-702 Phase II clinical trials Intermittent claudication Intermittent claudication Indigo Pharmaceuticals Inc.
drugs
Injectafer Awaiting approval Iron deficiency Blood-disorder treatments Luitpold Pharmaceuticals Inc.
Kogenate Liposomal Phase II clinical trials Hemophilia A Blood-disorder treatments Bayer HealthCare
LGD-4665 Phase II clinical trials Idiopathic thrombocytopenic Blood-disorder treatments Ligand Pharmaceuticals Inc.
purpura
Liprostin Phase II clinical trials Peripheral arterial occlusion Blood-disorder treatments Endovasc Inc.
Long Acting rFactor IX Phase I clinical trials Hemophilia B Blood-disorder treatments Biogen Idec Inc., Biovitrum AB
Maxy-G34 Phase II clinical trials Neutropenia Blood-disorder treatments Maxygen Inc.
MER-102 Phase I clinical trials Thrombosis Blood-disorder treatments Merrion Pharmaceuticals LLC
Mircera Phase II clinical trials Chemotherapy-induced Blood-disorder treatments Hoffmann-La Roche Inc.
anemia
Mozobil Awaiting approval Hematopoietic stem cells Blood-disorder treatments Genzyme Oncology Inc.
mobilization
MPC-0920 Phase I clinical trials Thrombosis Blood-disorder treatments Myriad Pharmaceuticals Inc.
MRX-815 Phase I/II clinical trials Peripheral arterial occlusion Blood-disorder treatments ImaRx Therapeutics Inc.
NN1731 Phase II clinical trials Bleeding Blood-disorder treatments Novo Nordisk Inc.
NN7128 Phase I clinical trials Bleeding Blood-disorder treatments Novo Nordisk Inc.
Nplate Phase II clinical trials Chemotherapy-induced Blood-disorder treatments Amgen Inc.
thrombocytopenia
NU172 Phase I clinical trials Anticoagulant Blood-disorder treatments Nuvelo Inc.
NutreStore Phase II/III clinical trials Sickle cell disease Blood-disorder treatments Emmaus Medical Inc.
OBI-1 Phase II clinical trials Hemostasis management Blood-disorder treatments Ipsen Inc.
Oral Heparin Phase III clinical trials Blood clot regulation Blood-disorder treatments Emisphere Technologies Inc.
Oxycyte Phase II clinical trials Blood substitute Blood-disorder treatments Oxygen Biotherapeutics Inc.
PD-348292 Phase II clinical trials Thrombosis Blood-disorder treatments Pfizer Inc.
PentaLyte Phase II clinical trials Hypovolemia Blood-disorder treatments BioTime Inc.
PHER-O2 Phase II clinical trials Blood substitute Blood-disorder treatments Sanguine Corp.
Plasmin Phase I/II clinical trials Acute peripheral arterial Blood-disorder treatments Talecris Biotherapeutics Inc.
occlusion
PMX-60056 Phase I clinical trials Blood clot regulation Blood-disorder treatments PolyMedix Inc.
PolyHeme Awaiting approval Blood substitute Blood-disorder treatments Northfield Laboratories Inc.
Promacta Awaiting approval Idiopathic thrombocytopenic Blood-disorder treatments GlaxoSmithKline Inc.
purpura
Promacta Phase II clinical trials Chemotherapy-induced Blood-disorder treatments GlaxoSmithKline Inc.
thrombocytopenia
Propionyl-L-Carnitine Phase III clinical trials Intermittent claudication Intermittent claudication Sigma-Tau Pharmaceuticals
drugs Inc.
R1663 Phase I clinical trials Thrombosis Blood-disorder treatments Hoffmann-La Roche Inc.
R788 Phase II clinical trials Immune thrombocytopenic Blood-disorder treatments Rigel Pharmaceuticals Inc.
purpura
rFVIIa Subcutaneous Phase I clinical trials Hemophilia Blood-disorder treatments Novo Nordisk Inc.
rFXIII Phase I clinical trials Cardiac surgery Blood-disorder treatments Novo Nordisk Inc.
87
Developer/partner
developer
Rifalazil Phase III clinical trials Intermittent claudication Intermittent claudication ActivBiotics Inc.
drugs
Rivaroxaban Awaiting approval Deep-vein thrombosis Blood-disorder treatments Bayer HealthCare
Johnson & Johnson
Development
Rivaroxaban Phase III clinical trials Venous thromboembolism Blood-disorder treatments Bayer HealthCare
Johnson & Johnson
Development
Rivaroxaban Awaiting approval Pulmonary embolism Blood-disorder treatments Bayer HealthCare
Johnson & Johnson
Development
SPP200 Phase II clinical trials Vascular graft occlusion Blood-disorder treatments Speedel Pharmaceuticals Inc.
Sym001 Phase I clinical trials Idiopathic thrombocytopenic Blood-disorder treatments Symphogen AS, Biovitrum AB
purpura
Sym001 Phase I clinical trials Hemolytic disease Blood-disorder treatments Symphogen AS, Biovitrum AB
TAK-442 Phase II clinical trials Venous thromboembolism Blood-disorder treatments Takeda Pharmaceuticals
North America Inc.
Thrombin Receptor Phase III clinical trials Arterial thrombosis Blood-disorder treatments Schering-Plough Corp.
Antagonist
Totrombopag Phase I clinical trials Thrombocytopenia Blood-disorder treatments GlaxoSmithKline Inc.
Trinam Phase III clinical trials Blood disorders Blood-disorder treatments Ark Therapeutics Group plc.
Veltuzumab Phase I/II clinical trials Immune thrombocytopenic Blood-disorder treatments Immunomedics Inc.
purpura
VT-211 Phase I clinical trials Neutropenia Blood-disorder treatments Vicus Therapeutics
VT-212 Phase I clinical trials Neutropenia Blood-disorder treatments Vicus Therapeutics
YM150 Phase II clinical trials Venous thromboembolism Blood-disorder treatments Astellas Pharma US Inc.
YSPSL Phase II clinical trials Delayed graft function Blood-disorder treatments Y’s Therapeutics Inc.
88
TOP 15 THERAPEUTIC GROUPS: DERMATOLOGY
Developer/partner
developer
ABT-874 Phase III clinical trials Psoriasis Dermatological products Abbott Laboratories
Aczone Phase II clinical trials Rosacea Dermatological products QLT Inc.
AHT956 Phase I clinical trials Psoriasis Dermatological products Novartis
AMG 714 Phase I clinical trials Psoriasis Dermatological products Amgen Inc.
AN0128 Phase I clinical trials Acne Dermatological products Anacor Pharmaceuticals Inc.
AN2728 Phase II clinical trials Psoriasis Dermatological products Anacor Pharmaceuticals Inc.
Apremilast Phase II clinical trials Psoriasis Dermatological products Celgene Corp.
ART621 Phase II clinical trials Psoriasis Dermatological products Arana Therapeutics Ltd.
ASC-J9 Phase I clinical trials Acne Dermatological products AndroScience Corp.
Asord Phase II clinical trials Psoriasis Dermatological products CollaGenex
ATX-201 Phase II clinical trials Actinic keratosis Dermatological products Kythera
Avrina Phase I clinical trials Eczema Dermatological products Transcription Factor
Therapeutics (TFT)
AZX100 Phase I clinical trials Keloid scarring Dermatological products OrthoLogic Corp.
AZX100 Phase I clinical trials Hypertrophic scarring Dermatological products OrthoLogic Corp.
BCX-4208 Phase II clinical trials Plaque psoriasis Dermatological products BioCryst Pharmaceuticals Inc.
CB-03-01 Phase I clinical trials Skin conditions Dermatological products Cosmo Pharmaceuticals
CF101 Phase II clinical trials Psoriasis Dermatological products Can-Fite BioPharma Ltd.
Chrysalin Phase I/II clinical trials Diabetic foot ulcers Dermatological products OrthoLogic Corp.
CIP-Isotretinoin Awaiting approval Acne Dermatological products Cipher Pharmaceuticals Inc.
COL-118 Phase II clinical trials Skin redness Dermatological products CollaGenex
CollaRx Gentamicin Topical Phase II clinical trials Diabetic foot ulcers Dermatological products Innocoll Inc.
CP-690550 Phase II clinical trials Psoriasis Dermatological products Pfizer Inc.
CRx-191 Phase II clinical trials Psoriasis Dermatological products CombinatoRx Inc.
CRx-191 Phase II clinical trials Skin atrophy Dermatological products CombinatoRx Inc.
CRx-197 Phase I/II clinical trials Dermatitis Dermatological products CombinatoRx Inc.
E6201 Phase II clinical trials Psoriasis Dermatological products Eisai Inc.
Elidel Phase III clinical trials Atopic dermatitis Dermatological products Novartis
Enbrel Awaiting approval Psoriasis Dermatological products Amgen Inc.,
Excellarate Phase II clinical trials Diabetic foot ulcers Dermatological products Tissue Repair Co.
Hectorol Phase I clinical trials Psoriasis Dermatological products Genzyme Corp.
Hivenyl Phase II clinical trials Itching Dermatological products Stiefel Laboratories Inc.
HspE7 Phase II clinical trials Genital warts Dermatological products Nventa
HuMax-IL8 Phase I/II clinical trials Palmoplantar pustulosis Dermatological products Genmab Inc.
ILV-094 Phase I clinical trials Psoriasis Dermatological products Wyeth Pharmaceuticals
Imvamune Phase II clinical trials Atopic dermatitis Dermatological products Bavarian Nordic AS
INCB18424 Phase II clinical trials Psoriasis Dermatological products Incyte Corp.
Incyclinide Phase II clinical trials Rosacea Dermatological products CollaGenex
Isolagen Therapy Phase III clinical trials Wrinkles Dermatological products Isolagen Inc.
Isolagen Therapy Phase II/III clinical trials Scars Dermatological products Isolagen Inc.
Juvista Phase II clinical trials Scars Dermatological products Shire US Inc.
LARx Awaiting approval Lice Dermatological products Sciele Pharma Inc.
Lemuteporfin Phase I/II clinical trials Acne Dermatological products QLT Inc.
89
TOP 15 THERAPEUTIC GROUPS: DERMATOLOGY
Developer/partner
developer
Levulan Kerastick Phase II clinical trials Acne vulgaris Dermatological products Dusa Pharmaceuticals Inc.
MAL Cream Phase II clinical trials Acne Dermatological products PhotoCure ASA
MEDI-545 Phase I clinical trials Psoriasis Dermatological products MedImmune Inc.
Menadione Phase I clinical trials Skin rash Dermatological products Hana Biosciences Inc.
MM-093 Phase II clinical trials Psoriasis Dermatological products Merrimack
NPI 32101 Phase II clinical trials Atopic dermatitis Dermatological products Nucryst Pharmaceuticals
Omiganan Phase II clinical trials Rosacea Dermatological products Cutanea Life Sciences Inc.
OrCel Awaiting approval Venous ulcers Dermatological products Forticell Bioscience Inc.
OrCel Phase III clinical trials Diabetic foot ulcers Dermatological products Forticell Bioscience Inc.
Otelixizumab Phase I clinical trials Psoriasis Dermatological products Tolerx Inc.
PEP005 Topical Phase III clinical trials Actinic keratosis Dermatological products Peplin Ltd.
Primolux Phase III clinical trials Psoriasis Dermatological products Stiefel Laboratories Inc.
Primolux Phase III clinical trials Atopic dermatitis Dermatological products Stiefel Laboratories Inc.
Psoraxine Phase II clinical trials Psoriasis Dermatological products Astralis Ltd.
PTH (1-34) Phase II clinical trials Psoriasis Dermatological products Manhattan
R348 Phase I clinical trials Psoriasis Dermatological products Rigel Pharmaceuticals Inc.
Retinoic acid Phase I clinical trials Acne Dermatological products Phosphagenics Ltd.
RGN-137 Phase II clinical trials Epidermolysis bullosa Epidermolysis bullosa therapies RegeneRx
RGN-137 Phase II clinical trials Venous stasis ulcers Dermatological products RegeneRx
RGN-137 Phase II clinical trials Chronic pressure ulcers Dermatological products RegeneRx
Roflumilast Phase I clinical trials Psoriasis Dermatological products Nycomed Group
Roflumilast Phase I clinical trials Atopic dermatitis Dermatological products Nycomed Group
S-777469 Phase II clinical trials Atopic dermatitis Dermatological products Shionogi USA Inc.
Sculptra Awaiting approval Nasolabial fold wrinkles Dermatological products Sanofi-Aventis
Sonedenoson Phase II clinical trials Diabetic foot ulcers Dermatological products King Pharmaceuticals Inc.
SUN 1334 H Phase II clinical trials Urticaria Dermatological products Sun Pharmaceutical
Industries Ltd.
SUN13834 Phase I clinical trials Atopic dermatitis Dermatological products Daiichi Sankyo Inc.
Talactoferrin Phase II clinical trials Diabetic ulcers Dermatological products Agennix Inc.
TD101 Phase I clinical trials Pachyonychia congenita Sleep-disorder treatment TransDerm Inc.
Topical Genital Warts Awaiting approval Genital warts Dermatological products Onset Therapeutics
Therapy
TRK-820 Phase II clinical trials Uremic pruritis Dermatological products Acologix Inc.
Ustekinumab Awaiting approval Plaque psoriasis Dermatological products Centocor Inc.
Veregen Phase II clinical trials Actinic keratosis Dermatological products MediGene AG
Xantryl Phase II clinical trials Psoriasis Dermatological products Provectus
Xantryl Phase II clinical trials Atopic dermatitis Dermatological products Provectus
Xiaflex Phase II clinical trials Peyronie’s disease Peyronie disease therapies Auxilium Pharmaceuticals Inc.
Xyfid Phase II clinical trials Chemotherapy-induced Dermatological products VioQuest
hand and foot syndrome Pharmaceuticals Inc.
Xyfid Awaiting approval Dermatoses Dermatological products VioQuest
90
TOP 15 THERAPEUTIC GROUPS: AUTOIMMUNE DISEASE
Developer/partner
developer
2nd Generation Anti-CD20 Phase III clinical trials Lupus nephritis Lupus drugs Biogen Idec Inc., Genentech
2nd Generation Anti-CD20 Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Biogen Idec Inc., Genentech
Actemra Phase I clinical trials Systemic lupus erythematosus Lupus drugs Chugai Pharmaceutical Co.
Alemtuzumab Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Genzyme Corp.,
Bayer HealthCare
Alferon N Injection Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Hemispherx Biopharma Inc.
ALV003 Phase I clinical trials Celiac disease Autoimmune disease Alvine Pharmaceuticals Inc.
therapies
AMG 557 Phase I clinical trials Systemic lupus erythematosus Lupus drugs Amgen Inc.
AMG 623 Phase I clinical trials Systemic lupus erythematosus Lupus drugs Anthera Pharmaceuticals Inc.
AMG 811 Phase I clinical trials Systemic lupus erythematosus Lupus drugs Amgen Inc.
ASP1002 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Asphelia Pharmaceuticals Inc.
AT-1001 Phase II clinical trials Celiac disease Autoimmune disease Alba Therapeutics Corp.
therapies
Atacicept Phase II/III clinical trials Systemic lupus erythematosus Lupus drugs Merck Serono SA
Atacicept Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Merck Serono SA
Atacicept Phase II/III clinical trials Lupus nephritis Lupus drugs Merck Serono SA
AZD5904 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs AstraZeneca
Pharmaceuticals LP
BAF312 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Novartis
BaroFeron Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs BaroFold Inc.
BG-12 Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Biogen Idec Inc.,
Fumapharm AG
BHT-3009 Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Bayhill Therapeutics Inc.
C1-INH Awaiting approval Hereditary angioedema Immune deficiency disorder CSL Behring
therapies
CC-11006 Phase I clinical trials Immunological diseases Immune deficiency disorder Celgene Corp.
therapies
CCX140 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs ChemoCentryx Inc.
CCX915 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs ChemoCentryx Inc.
CDP323 Phase II clinical trials Multiple sclerosis-relapsing Multiple sclerosis drugs UCB Pharma Inc.,
forms Biogen Idec Inc.
CellCept Phase III clinical trials Lupus nephritis Lupus drugs Aspreva
CellCept Phase III clinical trials Pemphigus vulgaris Autoimmune disease Aspreva
therapies Pharmaceuticals Corp.,
Copaxone Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Teva Pharmaceutical
Industries Ltd.
CPG 52364 Phase I clinical trials Systemic lupus erythematosus Lupus drugs Pfizer Inc.
CS-0777 Phase I clinical trials Immunological allergic Immune deficiency disorder Daiichi Sankyo Inc.
diseases therapies
CSL718 Phase III clinical trials Primary immunodeficiency Immune deficiency disorder CSL Behring
therapies
Daclizumab Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs PDL BioPharma Inc.,
Biogen Idec Inc.
DX-88 Subcutaneous Awaiting approval Hereditary angioedema Immune deficiency disorder Dyax Corp.
therapies
Epratuzumab Phase II clinical trials Systemic lupus erythematosus Lupus drugs UCB Pharma Inc.
91
Developer/partner
developer
Epratuzumab Phase II clinical trials Sjogren syndrome Autoimmune disease Immunomedics Inc.
therapies
Extavia Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Novartis
Fampridine-SR Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Acorda Therapeutics Inc.
Firategrast Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs GlaxoSmithKline Inc.
FTY720 Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Novartis
Gammagard Liquid Phase I/II clinical trials Primary immunodeficiency Immune deficiency disorder Baxter Healthcare Corp.
Subcutaneous therapies
Icatibant Awaiting approval Hereditary angioedema Immune deficiency disorder Jerini AG
therapies
IVIG Phase III clinical trials Primary immunodeficiency Immune deficiency disorder Omrix
therapies Biopharmaceuticals Inc.
Laquinimod Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Teva Pharmaceuticals
USA Inc.
LCP-Siro Phase I clinical trials Autoimmune diseases Autoimmune disease LifeCycle Pharma AS
therapies
LymphoStat-B Phase III clinical trials Systemic lupus erythematosus Lupus drugs Human Genome Sciences
LymphoStat-B Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Human Genome Sciences
MBP8298 Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs BioMS Medical Corp.,
Eli Lilly and Co.
MCT-125 Phase II clinical trials Multiple sclerosis fatigue Multiple sclerosis drugs MultiCell Technologies Inc.
MEDI-545 Phase II clinical trials Systemic lupus erythematosus Lupus drugs MedImmune Inc.
MEDI-545 Phase I clinical trials Myositis Myositis therapies MedImmune Inc.
MLN0415 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Millennium: The Takeda
Oncology Company,
Sanofi-Aventis
MLN3897/ AVE9897 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Millennium: The Takeda
Oncology Company, Sanofi-
Aventis
MM-093 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Merrimack
MTRX1011A Phase I clinical trials Autoimmune diseases Autoimmune disease Tolerx Inc., Genentech Inc.
therapies
Nerispirdine Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Sanofi-Aventis
NeuroVax Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Orchestra Therapeutics Inc.
ONO-4641 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Ono Pharma USA Inc.
Oral Cladribine Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs EMD Serono Inc., Teva
Pharmaceuticals USA Inc.
PI-2301 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Peptimmune Inc.
Prestara Awaiting approval Systemic lupus erythematosus Lupus drugs Genelabs Technologies Inc.
R1295 Phase I clinical trials Multiple sclerosis Multiple sclerosis drugs Hoffmann-La Roche Inc.
R3477 Phase I clinical trials Autoimmune diseases Autoimmune disease Hoffmann-La Roche Inc.,
therapies Actelion Pharmaceuticals
US Inc.
Rebif with Rebiject II Awaiting approval Multiple sclerosis Multiple sclerosis drugs EMD Serono Inc.
Auto-Injector
Revimmune Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Accentia
Rhucin Phase III clinical trials Hereditary angioedema Immune deficiency disorder Pharming Group NV
therapies
rhuMAb IFNAlpha Phase I clinical trials Systemic lupus erythematosus Lupus drugs Genentech Inc.
Riquent Awaiting approval Lupus erythematosus Lupus drugs La Jolla Pharmaceutical Co.
92
Developer/partner
developer
Rituxan Phase III clinical trials Lupus nephritis Lupus drugs Biogen Idec Inc., Genentech
Rituxan Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Biogen Idec Inc., Genentech
RPI-78M Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Receptopharm Inc.
Teriflunomide Phase III clinical trials Multiple sclerosis Multiple sclerosis drugs Sanofi-Aventis
Tovaxin Phase II clinical trials Multiple sclerosis Multiple sclerosis drugs Opexa Therapeutics Inc.
TRX1/Anti-CD4 Phase I clinical trials Lupus erythematosus Lupus drugs Tolerx Inc.,
Genentech Inc.
VX-509 Phase I clinical trials Immune-mediated Autoimmune disease Vertex Pharmaceuticals Inc.
inflammatory diseases therapies
93
TOP 15 THERAPEUTIC GROUPS: WOMEN’S HEALTH
Developer/partner
developer
221149 Phase II clinical trials Premature labor Premature labor therapies GlaxoSmithKline Inc.
ASP0265 Phase I clinical trials Endometriosis Endometriosis therapies Astellas Pharma US Inc.
Cetrorelix Phase III clinical trials Endometriosis Endometriosis therapies AEterna Zentaris Inc.
Corifollitropin Alfa Phase III clinical trials Infertility Infertility agents Schering-Plough Corp.
CP-866087 Phase II clinical trials Female sexual disorder Women’s hormone therapies Pfizer Inc.
CTP-347 Phase I clinical trials Vasomotor symptoms Women’s hormone therapies Concert Pharmaceuticals Inc.
DUB-OC Awaiting approval Prevention of pregnancy Contraceptives Bayer HealthCare
DUB-OC Phase III clinical trials Dysfunctional uterine bleeding Menstrual disorders Bayer HealthCare
E2 Plus DHEA Phase II clinical trials Prevention of pregnancy Contraceptives Bayer HealthCare
E2 Plus DRSP Phase II clinical trials Prevention of pregnancy Contraceptives Bayer HealthCare
FC Patch Fidencia Phase II clinical trials Prevention of pregnancy Contraceptives Bayer HealthCare
Femathina Phase II clinical trials Endometrial thinning prior to Endometriosis therapies Meditrina
endometrial ablations Pharmaceuticals Inc.
Femoston Low Dose Phase III clinical trials Hormone replacement Women’s hormone therapies Solvay Pharmaceuticals Inc.
therapy
Gestiva Awaiting approval Premature labor Premature labor therapies KV Pharmaceutical Co.
Hyperglycosylated FSH Phase II clinical trials Infertility Infertility agents EMD Serono Inc.
Hyperglycosylated FSH Phase II clinical trials Ovulation induction Infertility agents EMD Serono Inc.
Lo Seasonique Awaiting approval Prevention of pregnancy Contraceptives Duramed
Low Dose Estrogen Phase II clinical trials Prevention of pregnancy Contraceptives Agile Therapeutics Inc.
Contraceptive Patch
Lybrel Phase III clinical trials Premenstrual dysphoric Premenstrual dysphoric Wyeth Pharmaceuticals
disorder therapies
Mirena Phase III clinical trials Menorrhagia Menstrual disorders Bayer HealthCare
Misopess Phase III clinical trials Induction of labor Induction of labor therapies Xanodyne
MN-221 Phase II clinical trials Premature labor Premature labor therapies MediciNova Inc.
MPI-676 Phase II clinical trials Endometriosis Endometriosis therapies Meditrina
NBI-56418 Phase II clinical trials Endometriosis Endometriosis therapies Neurocrine Biosciences Inc.
Nestorone Contraceptive Phase I clinical trials Prevention of pregnancy Contraceptives Antares Pharma Inc.
Gel
Nomac/E2 Phase III clinical trials Prevention of pregnancy Contraceptives Schering-Plough Corp.
PF-2413873 Phase I clinical trials Endometriosis Endometriosis therapies Pfizer Inc.
PH80 Phase II clinical trials Premenstrual syndrome Women’s hormone therapies Pherin Pharmaceuticals Inc.
Pristiq Awaiting approval Vasomotor symptoms Women’s hormone therapies Wyeth Pharmaceuticals
Prochieve 8% Phase III clinical trials Premature labor Premature labor therapies Columbia Laboratories Inc.
Proellex Phase III clinical trials Uterine fibroids Uterine fibrosis therapies Repros Therapeutics Inc.
Proellex Phase II clinical trials Endometriosis Endometriosis therapies Repros Therapeutics Inc.
Ushercell Phase II clinical trials Prevention of pregnancy Contraceptives Polydex Pharmaceuticals Ltd.
Valette Plus Phase II clinical trials Prevention of pregnancy Contraceptives Bayer HealthCare
Visanne Phase III clinical trials Endometriosis Endometriosis therapies Bayer HealthCare
XP12B Phase III clinical trials Heavy menstrual bleeding Menstrual disorders Xanodyne
94
TOP 15 THERAPEUTIC GROUPS: WOMEN’S HEALTH
Developer/partner
developer
Yasmin Plus Phase III clinical trials Prevention of pregnancy Contraceptives Bayer HealthCare
Yaz Flex Phase III clinical trials Prevention of pregnancy Contraceptives Bayer HealthCare
Yaz Plus Phase III clinical trials Prevention of pregnancy Contraceptives Bayer HealthCare
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SPECIAL REPORT NOVEMBER 2008

PharmaLive.com and Med Ad News editors present this

The lists for each therapeutic group detail:

TOP 15 THERAPEUTIC GROUPS.......................................................................................3

92 DIABETES & METABOLIC DISORDERS 153

133 331 HEMATOLOGY 82

Amongst the Top 15 Therapeutic Groups:

~ Cancer products in the pipeline account for 26.3%

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