TABLE I. Differentiation between ICD and ACD. Criteria co, ‘ACD Atrisk ‘Anyone, especially if Previously sensitized and repeated exposure and genetically predisposed ‘occupational exposure Mechanism ‘Nonimmunologic, direct Immunologic, delayed-type tissue damage hypersensitivity reaction Concentration of Usually high, dose effect Might be low threshold offending agent dose, all or nothing, ‘Common causative Water, soaps, solvents Poison ivy, poison oak, agents detergents, acids, ‘poison sumac, metals, bases, saliva, urine, cosmetics, medications, stool rubber, resins, adhesives Risk if atopic Increased Decreased ‘Symptoms Burning, stinging, Itching. Morphology Erythema, edema, Erythema, edema, vesicles, desquamation, papules, lichenification fissures Demareation Usually sharp, limited Sometimes sharp to area in contact with agent ‘Typical onset “Minutes to hour ‘Hours to days Histology ‘Spongiosis, primarily __Spongiosis, primarily ‘neutrophilic infiltrates lymphocytic infiltrates ‘Comparisons of irritant and allergic contact dermatitis Criteria Irritant Allergic People ai risk Anyone, expecially if repeated Genetically pedi and Mechanism : nonimmunologic ‘Concentration of agent — Usually high; dese effect Risk if atopic Increased Histology si « primarily fnfileates Symptoms Burning, stinging, soreness Appearances Erythemia, edema, desquamation, fisvures Toa intro no ‘Common apents agg mae eres ai a2 stool Diagnostic test None(Clinical Presentation Commenis a oe em te pind Epos feet lracs Cetra = Poo eS oie [sn Bema ‘else | [ed wwe dace = i "Pea hvee akg scr oueats fe. | Ges ew epee si Expl dt sn od tg necro rs pe fo [is ig De ena [es on cone prank ppd wi wm | scl wi oy oon ‘inmardoing Gravatar dlc Fost fo dist cant inves eras ON Eerie ancy i rnd De” [Cone pc ee fara Toe Pict” ilaseiogs shins dma pow. |eaelaameliva gems feet [Setanpe ti epics tenet pe Fe al heme en, Gos eat i 5 ia sky apa ae ismereearonc men eee ‘hn atl er Doge ein Sept a ro oo a rn er ea pS SSeS pea ab Boe be pons etapa kbp finenman ae cape ip oe ele Si aap pan a ET eee chide gy a [wg fob ar eases, Jodi real, enn rea Cn cma en ge Ferien rosin Wei ere flea ingen spe