300 Signs and Symptoms • Hyperprolactinemia (elevated prolactin

of Celiac Disease (adults hormone)

• Hypoprothrombinemia
and children) • Idiopathic Thrombocytopenic Purpura
MARCH 19, 2015 ~ ONEDISH2010 • Liver Enzymes, Elevated
• Macroamylasemia
300 Signs, Symptoms, Associated
• Macrocytosis
Disorders/Complications directly or
• Macrolipasemia
indirectly, resulting from celiac disease
• Magnesium, Low
and gluten sensitivity.
• Neutropenia
• Phosphorus, Low
Source: Cleo J. Libonati, RN,
• Plasma Proteins, Low
BSN, Recognizing Celiac Disease. “This
• Potassium, Low
list is now being used by celiac disease
• Prolonged Prothrombin Time
centers, national celiac organizations
• Transient Erythroblastopenia
and health organizations worldwide”.
• Zinc, Low
Blood System Symptoms
Body Composition Symptoms
Abnormal levels of blood components
Disorders of the body as a whole.
and quality of blood cells and plasma,
• Anorexia (Poor appetite)
detected by blood studies ordered by a
• Appetite, Increased
doctor.
• Cachexia (Wasting of the body)
• Anemia, Folic acid
• Loss of Vitality
• Anemia, Iron
• Obesity
• Anemia, Vitamin B12
• Weight Gain, Unexplained
• Anti-Endomysium Antibodies (EMA)
• Weight Loss, Unexplained
• Anti-Gliadin Antibodies (AGA)
Cardiovascular System Symptoms
• Anti-Tissue Transglutaminase
Disorders of the heart and blood vessels.
Antibodies (tTG)
• Angina Pectoris
• Associated Autoimmune Antibodies
• Aortic Vasculitis
• Bone Alkaline Phosphatase Enzyme,
• Atherosclerosis
Elevated
• Cardiomegaly
• Calcium, Low
• Coronary Artery Disease
• Cholesterol, Low (below 156)
• Easy Bruising (Ecchymosis)
• Coagulation Factors, Low
• Hypertension
• Copper, Low
• Idiopathic Dilated Cardiomyopathy
• Hemochromatosis
• Nosebleeds, Unexplained
• Glucose, Low or elevated
Digestive System Symptoms
• Homocysteine, Elevated
The following symptoms in this section
1
may be present alone or in any
combination in celiac disease. They
result from inflammation, damage,and
interference with normal function
caused by gluten exposure in the
digestive tract itself and/or nutritional
deficiencies. As you see, problems can
develop not only in the small intestine
where inflammation can be intense, but
also in other areas such as mucosal
tissues of the mouth, esophagus,
stomach and colon.
• Abdominal Distention (Bloating)
• Abdominal Pain
• Adenocarcinoma of the Small Intestine
• Aphthous Ulcers (Canker sores in
mouth)
• Autoimmune Cholangitis
• Beta Casein Enteropathy (Cow’s dairy
intolerance similar to celiac disease)
• Bleeding, Unexplained
• Cancer of the Esophagus
• Cancer of the Pharynx
• Candida Infections
• Carbohydrate Malabsorption
• Cheilosis (Red lips, cracking/ oozing at
corners of mouth)
• Colitis, Collagenous
• Colitis, Lymphocytic
• Colitis, Ulcerative
• Colonic Volvulus (Loop of intestine
twists causing strangulation of intestine)
• Constipation
• Constipation Alternating with Diarrhea
• Crohn’s Disease
• Defective Tooth Enamel (Yellow, white
spots, missing enamel)
• Delayed Gastric Emptying (Early
fullness after eating)
• Diarrhea, acute (Also called celiac
crisis)
• Diarrhea, chronic
• Duodenal Erosions in the Second Part
of Duodenum (Small ulcers)
• Dysphagia (Difficulty swallowing)
• Edema of Small Intestinal Lining
• Esophageal Small Cell Cancer
• Esophageal Motor Abnormalities (Poor
muscle activity/coordination)
• Gas
• Gastric Ulcer (Stomach ulcers)
• Gastric Ulcerations
• Gastritis, Collagenous
• Gastritis, Lymphocytic
• Gastro-Esophageal Reflux Disease
(GERD)
• Gastro-Intestinal Occult Bleeding
(Blood in stool that is not visible to
naked eye)
• Gluten Sensitive Enteritis
• Gums bleeding/ swollen (Purplish in
adults/ red in children)
• Heartburn
• H. Pylori Bacter (Infection of the
stomach)
• Impaired Gall Bladder Motility
• Irritable Bowel Syndrome
• Jejunitis, chronic
• Lactose Intolerance (Gas, bloating,
loose stools from milk)
• Laryngospasm
• Leaky Gut Syndrome
• Lymphoma
• Malabsorption of Nutrients
• Maltose Intolerance (Gas, bloating,
loose stools from maltose, a simple
carbohydrate)
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• Nausea
• Oral Mucosal Lesions (Mouth lesions)
• Plummer-Vinson Syndrome
• Post-cricoid Cancer
• Primary Biliary Cirrhosis (Bile backs up
in liver)
• Primary Sclerosing Cholangitis
(Scarring of bile ducts in liver)
• Small Bowel Intussusception (One loop
of intestine slips into another)
• Small Intestinal Bacterial Overgrowth
• Steatorrhea (Pale, smelly, floating
stool hard to flush or sticks to toilet)
• Sucrose Intolerance (Gas, bloating,
mucous in stool from sugar)
• Tongue (Beefy, red, smooth, burning)
• Tongue (Fiery red, smooth, swollen,
sore)
• Tongue (Magenta, swollen)
• Tongue (Pale, smooth, burning)
• Vomiting
Glandular System Symptoms
Disorders of the glands.
• Addison’s Disease (Adrenal gland
failure)
• Autoimmune Hepatitis
• Autoimmune Thyroiditis
(Hypothyroidism)
• Diabetes Mellitus Type I
• Diabetic Instability
• Gastro-Intestinal Complications of Type
1 Diabetes
• Grave’s Disease (Hyperthyroidism)
• Hepatic Granulomatous Disease
• Idiopathic Hypoparathyroidism
• Non-Alcoholic Fatty Liver Disease
• Pancreatic Insufficiency
• Parathyroid Carcinoma
• Primary Hyperparathyroidism
• Secondary Hypoparathyroidism
Immune System Symptoms
Disorders of antibody production.
• Allergic Rhinitis
• Antiphospholipid Syndrome
• Asthma
• Autoimmune Disorders in Celiac
Disease
• Autoimmune Disorders in Dermatitis
Herpetiformis
• Autoimmune Polyglandular Syndromes
• Common Variable Immunodeficiency
• Food Allergies, IgE and non-IgE
Immune Responses
• IgA Deficiency
• Sarcoidosis
• Sjögrens Syndrome
• Systemic Lupus Erythematosus
• Urticaria, chronic (Hives)
Integumentary System Symptoms
Disorders of skin, hair, and nails.
• Alopecia Areata (Patches of hair loss)
• Alopecia, Diffuse (Balding)
• Cutaneous Vasculitis
• Cutis Laxa
• Dermatitis Herpetiformis
• Dermatomyositis
• Eczema
• Edema (Swelling)
• Eythema Elevatum Diutinum
• Erythema Nodosum
• Follicular Hyperkeratosis (Dry rough
skin/ plugged hair follicles on body)
• Ichthyosis, Acquired
• Itchy Skin Rash
• Hangnail
• Koilonychia (Thin nails that flatten,
3
ends progressively turning up instead of • Muscle Spasm and Cramps
down) • Muscle Wasting
• Melanoma • Muscle Weakness
• Nails, Dry and brittle that chip, peel, • Osteomalacic Myopathy
crack or break easily • Polymyositis
• Nails with Horizontal and Vertical • Tetany
Ridges/Fragile Nervous System Symptoms
• Nail with Rounded and Curved Down Disorders of nerves, brain and spinal
Ends, Dark, Dry cord structure and function.
• Nails with White Spots • Anxiety
• Nails with Splinter Hemorrhages • Apathy
• Pityriasis Rubra Pilaris • Ataxia, Gait Disturbance
• Prurigo Nodularis (Hyde’s Prurigo) • Ataxia, Gluten
• Psoriasis • Ataxia, Progressive Myoclonic
• Scleroderma • Brain Atrophy
• Seborrhea • Cerebral Perfusion Abnormalities (Poor
• Thin hair blood flow)
• Vitiligo • Chonic Fatigue Syndrome
Lymphatic System Symptoms • Chorea
Disorders of the lymphocytes (white • Cortical Calcifying Angiomatosis
blood cells), lymph nodes and spleen. • Dementia
• B-cell non-Hodgkin’s Lymphoma • Depression
• Cryptic Intestinal T-cell Lymphoma • Epilepsy
(Refractory Sprue) • Fatigue/ Lassitude
• Enteropathy Associated T-cell • Headache
Lymphoma (EATL) • Inability to Concentrate
• Extraintestinal Lymphomas • Insomnia
• Intraepithelial Lymphocytosis in Small • Irritability
Bowel Samples • Migraine
• Lymphadenopathy • Multiple Sclerosis
• Mesenteric Lymph Node Cavitation • Nervous System Disorders
• Hyposplenism (Atrophy of spleen) • Peripheral Neuropathy
Muscular System Symptoms • Progressive Multifocal
Disorders of muscle structure and Leukoencephalopathy
function. • Schizophrenic Spectrum Disorders
• Hypokalemic Rhabdomyolysis (Acute, • Tremors
severe potassium deficiency) • Vasculitis of the Central Nervous
• Muscle Pain and Tenderness System
4
Pulmonary System Symptoms • Psoriatic Arthritis
Disorders of lung tissue and broncheal • Recurrent Monoarthritis
tree structure and function. Urinary System Symptoms
• Bronchiectasis Disorders of kidneys and urinary tract
• Bronchial Pneumonia structure and function.
• Idiopathic Pulmonary Hemosiderosis • Hypocalciuria
• Increased Pulmonary Permeability • IgA Nephropathy
• Increased Susceptibility to Tuberculosis • Kidney Stones
• Lung Cavities or Abcess • Urinary Tract Infection
• Non-Response to Tuberculosis Reproductive System Symptoms in
Treatment Females
• Pneumococcal Septicemia Disorders of organ structure and
Sensory System Symptoms function.
Disorders of sense organ structure and • Amenorrhea (Absence of menstrual
function. period)
• Bitot’s Spots (Foamy patches on • Early Menopause
whites of eye) • Infertility
• Blepharitis • Late Menarche (Late start of menstrual
• Bloodshot Eyes periods)
• Blurred Vision • Premenstrual Syndrome
• Cataracts • Dysmenorrhea (Painful menstrual
• Keratoconjunctivitis Sicca periods)
• Keratomalacia • Dyspareunia (Painful intercourse)
• Nightblindness • Vaginitis
• Ocular Myopathy Reproductive System Symptoms in
• Smell, Loss of Males
• Taste, Loss of Disorders of organ structure and
• Uveitis, Bilateral function.
• Xerophthalmia • Hypogonadism
Skeletal System Symptoms • Impotence
Disorders of bone, joints and teeth. • Infertility
• Bone Fracture • Sperm Abnormalities
• Bone Pain Reproduction: Pregnancy, Labor &
• Enteropathic Arthritis Delivery and Puerperium Symptoms
• Osteitis Fibrosa Disorders of childbearing.
• Osteomalacia • Severe Iron Deficiency Anemia in
• Osteonecrosis Pregnancy
• Osteoporosis • Short Duration of Breast Feeding
5
• Miscarriage Small Intestine (Lack of enzymes
• Complications During Pregnancy, produced by villi)
Labor and Delivery • Penicilllin V Impaired Absorption
• Complications After Childbirth • Refractory Anemia (Unresponsive to
Zygote Development Symptoms iron therapy)
Disorders of chromosomes. • Osteopenia
• Down Syndrome • Rickets
• Turner’s Syndrome • Short Staure
Fetus Development Symptoms • Stroke in Childhood
Disorders of that occur before birth of Here are some other ways to look at
the child. various symptoms:
• Congenital Anomalies Behavioral Symptoms
• Intrauterine Growth Retardation • Aloofness
• Cystic Fibrosis • Hyperactivity
• Spina Bifida • Irritability (Common in children with
Child Development Symptoms celiac disease)
Disorders of children that occur after • Impatience
birth. • Lack of Desire to Get Things Done
• Autism and Learning Disorders • Lack of Feeling
• Attention Deficit Hyperactive Disorder • Restlessness
(ADHD) • Timid Behavior
• Cancer Predisposition in Children • Violent Behavior
• Chronic Bullous Dermatosis Neurological Issues
• Delayed Puberty in Boys • Anxiety
• Delayed Puberty in Girls • Apathy
• Dermatitis Herpetiformis • Bipolar disorder
• Developmental Delay • Depression
• Failure to Thrive and Growth • Difficulty Making Friendships
Retardation • Easy Frustration and Anger
• Fecal Occult Blood (Blood found in • Nervousness
stool that is not visible to the naked eye) • Panic Attacks
• Glycogenic Acanthosis • Sense of Worthlessness
• Hypotonia • Overly Self-critical
• Juvenile Autoimmune Thyroid Disease • Hysteria
• Juvenile Diabetes Type 1 • Hypochondria
• Juvenile Idiopathic Arthritis Cognitive (Thinking) Symptoms
• Abnormal Blood Studies • Confused/ Faulty Thinking
• Latent Anemia in Enzymopathies of • Confabulation
6
• Delusions
• Dementia
• Disorientation
• Faulty Learning
• Hallucination
• Inattentiveness
• Loss of Memory
• Loss of Immediate Memory
• Poor Memory
• Reduced Learning
• Slow Thinking
• Scattered Thinkin