CENTRAL COUNCIL FOR RESEARCH IN HOMOEOPATHY

SALIENT ACHIEVEMNTS OF RESEARCH STUDIES CONCLUDED

Sl. Name of the project and Period Salient findings Remarks

no Place of the study
1. Clinical evaluation of • Different clinical patterns were observed, viz.
homoeopathic medicines in 1985 - 2003 acute/chronic, frontal, fronto-maxillary (mixed),
sinusitis sphenoidal and multiple sinusitis.
• Though 83% of cases improved in varying degree with
Place(s) of study: homoeopathic therapy, 31% cases were cured with
complete removal of subjective and objective symptoms
- Regional Research Institute and no relapse occurred for one year.
(Hom.), Shimla • Belladonna, Kali bichromicum, Lachesis, Natrum
- Clinical Research Unit sulphuricum, Pulsatilla), Rhus toxicodendron and
(Hom.), Chennai. Silicea are most indicated and effective medicines.
2. Clinical evaluation of • Drug dependent cases were referred from Nav-Chetna
homoeopathic medicines in 1988 - 1994 Drug De-addiction centre, Varanasi.
the management of • Out of 241 cases that followed up regularly; 83% cases
withdrawal symptoms of drug showed improvement in withdrawal symptoms.
dependents’. • Rhus toxicodendron was found to be most effective
medicine. Other medicines found effective are Avena
Place(s) of study: sativa, Nux vomica, Arsenic album, Bryonia alba and
Chamomilla.
Clinical Research Unit (Hom.), • Rhus toxicodendron, Arsenic album and Chamomilla
Varanasi (U.P.). are found to be effective in 10M potency while Bryonia
alba and Nux vomica in 200C potency and Avena sativa
in mother-tincture.
3. Clinical evaluation of
1991 - 2001 • Common behavioural problems in mentally retarded
homoeopathic medicines in
children like aggressiveness, destructiveness,
behavioural problems of
disruptiveness etc. were studied.
mentally retarded children
• Out of 835 cases that followed up regularly 63% cases
Place(s) of study: showed improvement.
• Baryta carbonicum was the most effective medicine in
Central Research Institute
the treatment of behavioural problems in mentally
(Hom.), Kottayam (Kerala).
retarded children.
• Other medicines found effective are Antimonium
crudum, Argentum nitricum, Arsenicum album, Baryta
carbonicum, Baryta muriaticum, Belladonna, Cannabis
indica, Causticum, Chamomilla, Cina, Cuprum
metallicum, Gelsemium, Hyoscyamus, Kali bromatum,
Mercurius solubilis, Phosphorus, Pulsatilla,
Stramonium, Sulphur, Tarentula hispanica, and
Tuberculinum.
• In hyperactive children, Belladonna, Sulphur, Tarentula
hispanica and Tuberculinum are found more effective.
• In aggressive children, Belladonna, Hyoscyamus and
Tarentula hispanica are found more effective.
• In dull, backward and shy children Baryta carb., Baryta
mur., Opium and Pulsatilla are found more effective.
4. Clinical evaluation of
1987 - 2004 • Out of 406 cases followed up regularly, 51% cases
homoeopathic medicines in
showed significant improvement while 32% cases
the management of sickle
showed mild improvement.
cell anaemia
• Medicines found effective are Alumina, Arsenic album,
Place(s) of study: Bryonia alba, Ceanothus americanus, Chelidonium
majus, Kalmegh, Lecithinum, Natrum muriaticum,
- Clinical Research Unit Phosphorus, Pulsatilla nigricans, Rhus toxicodendron
(Hom.) at Sambalpur and Vanadium metallicum.
(Orrisa).
• Bryonia alba emerged as the most commonly indicated
medicine in controlling painful crisis attacks.
• In 45% of cases, Hb % improved from 7-9% to 9-11%.
• 10% of the cases which were followed up for 6 years
did not develop acute crisis under homoeopathic
treatment.

5. Clinical evaluation of
1987 - 2004 • Out of 3213 cases followed up, 73% cases showed
homoeopathic medicines in
significant improvement while 22% cases showed mild
chronic cervicitis and cervical
improvement.
erosion
• Medicines found effective are Alumina, Borax,
Place(s) of study: Calcarea carbonicum, Caulophyllum, Hydrastis,
Kreosotum, Lachesis, Mercurius solubilis, Natrum
- Clinical Research Units muriaticum, Pulsatilla and Sepia.
(Hom.) at Shimla, Imphal,
Varanasi, (U.P.), Tirupathi • Sepia alone emerged as the most frequently indicated
- Regional Research Institute medicine for cervicitis and cervical erosion.
(Hom.), at New Delhi • Cases that required repeated cauterization for their
erosion got relieved after homoeopathic treatment.
6. Clinical Evaluation
of Homoeopathic
Medicines in
Osteoarthritis
Place(s) of study:
- Clinical Research Institute
(Hom.), Kottayam, (Kerela)
- Regional Research Institute
(Hom.), Gudivada, (Andhra
Pradesh)
- Clinical Research Unit
(Hom.), Patiala, (Punjab).
7. Clinical evaluation of
Homoeopathic medicines in
Upper Respiratory Tract
Infections
Place(s) of study:
Clinical Research Cum
Epidemic Cell (Hom.), Bhopal.
8. Clinical evaluation of
Homoeopathic Medicines in
filariasis
Place(s) of study:
- Regional Research Institute
(Hom.), Puri, (Orissa)
- Regional Research Institute
(Hom.), Gudivada, (Andhra
Pradesh)
- Clinical Research Unit
(Hom.), Tirupathi, (Andhra
Pradesh).
• Although improvement was observed in 76% of the
treatment group, this was significantly seen in 47% of
1984 - 2005
the cases.
• A group of homoeopathic drugs has been identified and
found effective in relieving the symptoms and signs of
osteoarthritis when prescribed as per their indications.
• Most effective medicines are Arnica, Arsenicum album,
Bryonia alba, Calcarea carbonica, Calcarea fluoricum,
Causticum, Graphites, Lycopodium clavatum,
Medorrhinum, Natrum mur., Pulsatilla, Rhus
toxicodendron and Sulphur.
• Significant improvement has been observed in 90% of
the cases of acute rhinitis. Mild improvement was also
2000 - 2005 seen in 4% of the cases also.
• A group of fourteen medicines has been identified and
found effective in relieving the signs and symptoms of
acute rhinitis.
• Most frequently indicated and effective medicines are
Arsenicum album, Justicea adhatoda, Lemna minor and
Silicea.
• 79% of the cases improved in varying degrees and
significant improvement was achieved in 55% of the
1980 - 2003 cases.
• These 55% cases had complete absence of clinical
events for a period ranging from 2 to 3 years.
• A group of homoeopathic drugs has been identified and
found effective in relieving the symptoms and signs of
filariasis when prescribed as per their indications.
• Most indicated and effective medicines observed are
Rhus toxicodendron, Bryonia alba, Sulphur, Apis mel.,
Natrum muriaticum, Pulsatilla and Rhododendron.
• Homoeopathic medicines could disappear or reduce the
grade I and grade II lymphoedema in 79% of the cases.
• High potencies have been found useful in acute clinical
events.
9. Clinical evaluation of
homoeopathic medicines in
the management of Allergic
dermatitis.
Place(s) of study:
- Clinical Research Units
(Hom.) Gurgaon and
Patiala
10. Clinical evaluation of
homoeopathic medicines in
the management of bronchial
asthma.
Place(s) of study:
- Regional Research Institutes
(H) at New Delhi, Gudivada
(Andhra Pradesh) and Shimla
(Himachal Pradesh)
- Clinical Research Units (H)
at Udupi (Karnataka)
and Patiala (Punjab)
11. Drug Proving – Homoeopathic
pathogenetic Trials of new
and old drugs
1980-2003 • The outcome of the study shows that homoeopathic Further study with improved
medicines have effective role in managing Allergic parameters for diagnosis,
dermatitis. follow up and outcome
assessment will further
• Seventy five percent of the cases were significantly
strengthen the
improved, though mild improvement was also seen in
effectiveness of
other 21% of the cases.
homoeopathic medicines.
• The most indicated and efficacious medicines observed
are Apis mellifica, Bovista, Dulcamara, Graphites,
Natrum muriaticum, Petroleum, Rhus toxicodendron,
Sepia, Sulphur and Urtica urens.
• The study verified the reliability of symptoms of the
prescribed medicines in allergic dermatitis.
1978-2003 • The homoeopathic medicines have been found to have Further study with
effective role in managing acute attacks as well as in improved parameters for
controlling recurrent attacks of bronchial asthma. outcome assessment
(spirometery, etc.) will
• Sixty four percent of the cases had shown significant
further strengthen the role
improvement though mild improvement was also seen
of homoeopathic medicines
in other 24% of cases.
in the management of
• Arsenicum album has been found to be the most bronchial ashma.
indicated and effective medicine in the treatment of
asthma.
• Other most indicated and effective medicines found are
Hepar sulphuris, Kali carbonicum, Lycopodium
clavatum, Natrum sulphuricum, Phosphorus and
Pulsatilla nigricans.
• Viburnum opulus Q has been found effective during
acute attacks of asthma.
Since inception • The council has completed proving of 76 drugs. • 35 drugs are under
(1974 onwards) • 07 new drugs proved by the Council: Clinical Verification
i. Cassia fistula programme to verify
ii. Cassia sophera the data obtained
iii. Curcuma longa during drug proving.
iv. Cuscuta reflexa • Proving data of 06
v. Glycyrrhiza glabra drugs is under
vi. Phyllanthus niruri compilation.
vii. Bacopa monniere • The data so far
obtained has been
• 36 drugs are indigenous: sent to all the
1. Abroma augusta folia Homoeopathic Medical
2. Acalypha indica Colleges in India for
3. Acorus calamus their use.
4. Aegle folia
5. Aegle marmelos
6. Andrographis paniculata
7. Argemone mexicana
8. Atista indica
9. Azadirachta indica
10. Boerhaavia diffusa
11. Calotropis gigantea
12. Carica papaya
13. Cassia fistula
14. Cassia sophera
15. Cephalandra indica
16. Clerodendron infortunatum
17. Coleus aromaticus
18. Curcuma longa
19. Cuscuta reflexa
20. Cynodon dectylon
21. Embelia ribes
22. Ficus religiosa
23. Glycyrrhiza glabra
24. Holarrhena antidysenterica
25. Hydrocotyle asiatica
26. Mangifera indica
27. Nyctanthes arbortristis
28. Ocimum sanctum
29. Rauwolfia serpentina
30. Ricinus communis
31. Saraca indica
32. Terminalia arjuna
33. Terminalia chebula
34. Tinospora cordifolia
35. Tribulus terrestris
36. Tylophora indica

12. Clinical Verification of
Partially proved and lesser
known drugs from the
following literature Sources :
1. Clarke’s Materia Medica
2. Hering Guiding Symptoms
3. Allen’s Encyclopedia
4. Boericke’s Materia Medica
5. Drugs of Hindoostan
6. Provings conducted by
CCRH
1. The data of 62 drugs has been published for the
use of professionals.
2. Data of 08 drugs will be published shortly.
1979 - 2004 • Council completed clinical verification of 52 drugs since
inception of the project
• Focus was on fragmentarily proved drugs mainly of
indigenous origin.,
• Council has published data of 28 drugs, out of which 17
are indigenous. Main clinical conditions of these drugs
are mentioned below.
1. Abroma augusta folia – arthritis, diabetis mellitus.
2. Achyranthes aspera – coryza, stomatitis, diarrhoea, boils
3. Aegle folia – dyspepsia, diarrhoea, dysentery
4. Aegle marmelos – coryza, stye, vertigo, dysentery
5. Amygdalus persica – nausea, vomiting. morning sickness,
6. Anthrakokali – acute & chronic skin disorders
7. Atista indica - dysentery
8. Bacillinum – ringworm, lymph adenitis
9. Baryta iodata – tonsillitis, induration of glands
10. Berberis vulgaris – renal calculi,
11. Boerhaavia diffusa – hypertension, urinary troubles,
dropsical swelling
12. Cassia sophera – upper & lower respiratory tract
infections, arthritis.
13. Carica papaya – conjunctivitis, anorexia, constipation,
jaundice
14. Caesalpaenia bonducella - fever
15. Damiana – impotency, spermatorrhoea
16. Embelia ribes – intestinal worms, diarrhoea, flatulence
17. Hydrocotyle asiatica – stomatitis, constipation,
leucorrhoea, various skin diseases
18. Hygrophilla spinosa – renal calculi, UTI, leucorrhoea,
urticaria, fever
19. Jaborandi – falling of hair, graying of hair, acne,
headache
20. Justicea adhatoda – respiratory tract infections
21. Kali muriaticum – stomatitis, headache, otorrhoa,
otalgia, tonsillitis, coryza, constipation.
22. Lac caninum – rheumatic arthritis
23. Nyctanthes arbortristis – various kind of fevers,
constipation
24. Saraca indica – leucorrhoea, menstrual irregularities,
amenorrhoa, backache, constipation,
bleeding piles.
25. Sarsaparilla – constipation, UTI
26. Terminalia chebula – constipation, bleeding piles,
dyspepsia,
27. Tarentula hispanica – dyspepsia, constipation
28. Viscum album – hypotension, otorrhoea, palpitation,
arthritis
 Central Council for Research in Homoeopathy
S.No Name of the Project Salient findings Re
. ma
rks
Name of Drug Name of the Findings
Profile Studied
1. Drug Standardization Cocculus Part used: Fruit.
indicus Pharmacognosy Endocarp strongly lignified made up of pitted, thick-
walled fibers arranged in various planes. Seed coat
Hindi – Jermae, compressed, consists of disorganized, pigmented cells.
kakmari Endosperm massive and composed of polygonal cells
English – Fish- with thin-walls containing aleurone grains, oil droplets
berry, crow killer, and acicular crystals.
levant- berry,
poison-berry. Physico-chemical TLC studies: A) Toluene: ethyl acetate
: diethylamine (7:2:1 v/v) as mobile phase. (i) Under
U.V.light(366nm) one spot appears at Rf 0.83 (blue),(ii)
On spraying with Anisaldehyde sulphuric acid three spots
appear at 0.31(blue), 0.50(blue) and 0.72(grey).

Pharmacology The fruit and seed mother tincture were safe up to dose
level of 0.1 ml /100 g. b.w. in mice and 0.15 ml /100 g
.b.w. in rats, respectively. The drug does not show anti-
inflammatory action, fall in blood pressure & analgesic
activities but shows antipyretic effect.

2. Cochlearia Part used: Root.

armoracia Pharmacognosy Phellogen indistinct and phelloderm, thin-walled
followed by a wide zone of cortex of tangentially
elongated, oval or isodiametric parenchyma cells
English – Horse containing numerous starch grains; sclereids solitary or in
radish groups. Idioblasts contain brown contents present in
phelloderm, cortex and xylem parenchyma.
 TLC studies:
Physico-chemical (A) chloroform:methanol (9:1 v/v) as mobile phase.
(i) Under U.V.light two spots appear at Rf 0.54(greenish)
and 0.97(blue). (ii) On spraying with antimony tri
chloride in chloroform reagent four spots appear at Rf
0.39( pink), 0.51( violet), 0.67(violet),and 0.91(pink).
(B) n-butanol:acetic acid:n propanol:water(3:1:!:1 v/v) as
mobile phase.(i) On spraying with ferric cyanide
(potassium) ferric chloride reagent five blue spots appear
at Rf 0.50, 0.65, 0.76, 0.85 and 0.91.
Pharmacology The present study demonstrates that Cochlearia
armoracia Q is safe up to dose level of 0.15 ml/100g.b.w.
in mice and has no atrophic/ degenerative changes in any
endocrine glands. The drug does not show any
antiinflammatory, anti-pyretic, anti-convulsant, C.N.S.
activity and fall in blood pressure but shows analgesic
effect.

Holarrhena
antidysentrica
3. Pharmacognosy Part used: Dried bark.
Hindi– Kurchi,
karchi Stone cells arranged in concentric tangential bands,
English – Kurchi, associated with crystal sheath containing prisms of
conessi or calcium oxalate. Laticiferous ducts containing brownish
tellichery bark contents present in phloem. Rosettes or prisms of
calcium oxalate and starch present throughout
parenchymatous tissue.
Physico-chemical TLC studies:-
using chloroform: methanol (9:1v/v) as mobile phase and
on spraying the plate with Dragendorff’s reagent six
orange spots appear at Rf 0.20, 0.30, 0.65, 0.70, 0.80 and
0.90.

Pharmacology Q was safe up to dose level of 0.4 ml/ kg b.w. in rabbit.

4. . Gymnema Pharmacognosy Part used: Leaf
sylvestre Lamina: stomata paracytic occasionally anomocytic, only
on lower surface; trichomes numerous, multicellular,
Hindi – Gurmar, uniseriate, meristele shows crescent shaped, conjoint,
merasingi bicollateral vascular bundle embedded in parenchymatous
English–Periploca ground tissue. Rosette aggregates of calcium oxalate
of woods, small scattered throughout leaf. Stomatal index: 7-13, palisade
Indian ipecacuanha ratio: 4.25-8. Petiole shows horse-shoe shaped outline
Physico-chemical TLC studies :
A) Under U.V.light five spots appear at Rf 0.28(red),
0.47(red),0.57(blue), 0.89(red) and 0.94(red).
B) On exposure to iodine vapours six spots appear at Rf.
0.28, 0.47, 0.52, 0.76, 0.89 and 0. 94.

Pharmacology Q was safe up to dose level of 0.1 ml/100g. b.w. in mice

and 0.1 ml /100 g .b.w. in rats. G. sylvestre Q possess
mild hypoglycemic activity.

5. Tylophora Pharmacognosy Part used: Leaf.

indica Trichomes uniseriate, multicellular with longitudinal
striations; stomata paracytic, only on lower surface.
Hindi – Jangli- Starch grain, laticifers and numerous rosette aggregates of
pikvam, antamul calcium-oxalate in parenchyma tissue. Palisade ratio 7-
English– Emetic 8.3, Stomatal index 8.8-12.7.
swallowwort,India
n or Physico-chemical TLC studies :
(A)Under U.V.light (366nm) five spots appear at Rf
0.69(blue), 0.75(greenish), 0.80(blue), 0.86(blue) and
0.90(red).
(B) On spraying with Anisaldehyde sulphuric acid
reagent three spots appear at Rf 0.45(pink),0.70(blue) and
0.81(violet) .
Pharmacology Q (diluted) was safe up to dose level of 1.0 ml / 100
g.b.w. in mice but did not possess C.N.S. activity,
behavioural effect, respiratory and heart rate at the dose
level of 1.0 ml/100 g.b.w. in mice and also did not
possess any anti-fertility effect.