Myopathy

Surat Tanprawate, MD, MSc(Lond.), FRCP(T)

Division of Neurology, Department of Medicine
Chiang Mai University

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 Myofilament

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 Other supporting system

Sarcotubular system Dystrophin-glycoprotein

complex
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 Contraction
mechanism

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 Contraction
mechanism

Channelopathy
Dystrophin-
glycoprotein
complex

Mitochondrial
, metabolic
myopathy

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 Sliding of myofilament
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 Term of muscular
disorder
Myopathy

• Abnormality of muscle
Muscular dystrophy

• Genetic myopathy
• Usually caused by a disturbance of structural
protein

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 Term of muscular
disorder
Myotonia

• Disease: normal contractile protein is distorted by

the occurrence of involuntary, persistent muscle
activity, accompanied by abnormal repetitive
electrical discharge, which occur after percussion
or voluntary contraction

Myositis

• Inflammatory disorder of muscle and muscle

histology show an inflammatory response

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 Clinical manifestation

• Weakness • Contracture
• Muscular atrophy • Muscle spasm
• Pseudohypertrophy • Muscle pain
• Hypotonia • Myotonic reaction

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 Gower’s sign

Sir William Richard Gowers

British Neurologist (1845 –1915)

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 Gower’s sign

Sir William Richard Gowers

British Neurologist (1845 –1915)

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 Winged
scapula

Unilateral winged scapula

Arm flexion; push-up motion against a wall Bilateral winged scapula

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 Myotonia

Handgrip myotonia Percussion myotonia

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 Classification of muscle disease
“Clinical, pathophysiology, genetic”
• Hereditary • Acquired

• Muscular dystrophy • Inflammatory myopathy

• Myotonia and periodic • Endocrine myopathy

paralysis
(channelopathies) • Toxic/drug induced
myopathy
• Metabolic myopathy and
mitochondrial myopathy • Tumor associated myopathy

• Congenital myopathy • Ischemic myopathy

• Traumatic myopathy

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 Downloadable slide

www.openneurons.com

Friday, 28 January 2011