Summary of Peer Reviewed Clinical Studies on Protandim

Complete studies available at Pubmed.gov – search “Protandim”

1. “The Induction of Human Superoxide Dismutase and Catalase in Vivo: A fundamentally New Approach to
Antioxidant Therapy, Free Radical Biology and Medicine (2006) University of Colorado
● Protandim completely eliminates the age-related increase in cell aging factors, oxidative stress.
● Reduces oxidative stress by a minimum of 40 percent - to the progressive aging rate of a 20 year old.
● Significantly increases activity of SOD and CAT antioxidant enzymes by 54 percent - substantially increasing the
body’s antioxidant defenses.

2. “Synergistic Induction of Heme Oxygenase-1 by the Components of an Antioxidant Supplement Protandim”, Free
Radical Biology and Medicine (2008) University of Colorado
● Protandim produces a 300 percent increase in glutathione, a key antioxidant and anti-aging factor.
● Protandim’s synergistic formulation provides more antioxidant power than any food or supplement.

3. “Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin
Carcinogenesis as a Model”, PLoS ONE Journal (2009) Louisiana State University
● Reduced tumor incidence by 33% and tumor multiplicity by 57%.
● Increased expression of antioxidant and anti-inflammatory enzymes.
● Overall, induction of antioxidant enzymes by Protandim may serve as a practical and potent approach for cancer
prevention.

4. “Chronic Pulmonary Artery Pressure Elevation is Insufficient to Explain Right Heart Failure”, American Heart
Association, Circulation 2009 Virginia Commonwealth University
● Protandim prevented the formation of scar tissue in the heart
● Prevented capillary loss in the heart muscle; prevented death of heart cells.
● Osteopontin levels reduced by more than 50%.
● Heart output was preserved and cardiac fibrosis prevented.

5. “The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis
during Skin Carcinogenesis”, PLoS ONE Journal (2010) Louisiana State University
● Protandim's ability to modulate relationship between superoxide dismutase and tumor suppressor p53 believed
responsible for reduction of skin cancers.
● Protandim's ability to increase production of the body's Nrf2-regulated protective genes, sometimes referred to
as "survival genes".

6. “The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress
in Muscular Dystrophy Mdx Mice”, Journal of Dietary Supplements (2010) Harvard Medical School, Mass General
Hospital
● 48% decrease in plasma TBARS, a marker of lipid peroxidation and oxidative stress.
● 57% decrease in plasma Osteopontin, a fibrosis-promoting factor linked to heart failure,
● 35% increase in beneficial, protective plasma PON1 activity, an enzyme that protects against atherosclerosis by

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 preventing the oxidation of low-density lipoprotein (LDL) cholesterol.

7. “Protandim Attenuates Intimal Hyperplasia in Human Saphenous Veins Cultured ex vivo via a Catalase-Dependent
Pathway." Free Radical Biology and Medicine (2010) AHA, NIH, Ohio State University
● Protandim’s prevents the proliferation of cells that can cause re-blockage of vessels following coronary artery
bypass surgery, stenting, and carotid enarterectomy.
● Treatment with Protandim, reduced intimal proliferation to the level seen in a normal healthy saphenous vein.
PROTANDIM
A Promise of Protection
Developed after forty years of research, Protandim is a true scientific breakthrough in age-related diseases.
Protandim is a one-a-day, all natural supplement that activates our body’s internal defenses to sustain itself,
protecting our cells from damage and disease.

Protandim is a Nrf2 activator in the nutrigenomics arena. Nutrigenomics is the science of how dietary
components interact with the genome, or DNA, to regulate gene expression. Nutrigenomics studies how the
things we eat affect our genes. Nrf2 is a key protein in the body and regulates approximately 500 of the 25,000
genes in the body.

Think of every gene as having a “dimmer switch”. Nrf2 is the protein that can reach the dimmer switch.
Protandim helps your body balance and regulate its 25,000 genes by “turning some up” or “turning some
down”.

In fact, the 500 genes Protandim regulates are termed by scientists as “survival genes”. There are three
categories of survival genes: antioxidant enzymes (like SOD, catalase and glutathione), anti-inflammatory genes
(that fight the process of inflammation in the body) and anti-fibrotic genes (that fight the process of scar tissue
formation in the body; although scar tissue formation is helpful when you have a cut, scar tissue formation can
be fatal if it occurs in the heart and lungs.)

Independent research by Harvard, VCU, LSU and OSU, have validated this ability and measured Protandim’s
impact in tuning over 500 survival genes and what that means for our health and our battle against age-related
diseases, including cancer and heart disease. Additional studies are being conducted on osteoarthritis, diabetes,
HIV/AIDS, periodontal disease, asthma, reduced injury recovery rates, neurodegenerative diseases like
Parkinson’s and Alzheimer’s and many others.

Below are some of the genes tuned by Protandim, as demonstrated by seven published, peer-reviewed clinical
studies:
● Antioxidant enzymes increased over 40% - reducing oxidative stress and cellular aging
● Glutathione increased by 300% - antioxidant, blood booster, cell detoxifier
● Anti-inflammatory genes increased
● Anti-fibrotic genes increased – reducing scarring of the heart and lungs
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415-223-3965
www.SlowYourAging.info
 ● PON1 activity increased – protects against arteriosclerosis and oxidized LDL cholesterol
● P-53increased - a tumor suppressor gene
● Osteopontin reduced by 57%. – directly linked to a wide variety of cancers, autoimmune diseases, and
osteoporosis
● FABP-4 reduced by 85% - associated with multiple pro-inflammatory responses
● FABP -5 reduced by 66% - lowers likelihood of calcified arteries
● Akr1B10 increased - promotes cell survival

Protandim provides a remarkable promise of protection from all kinds of age-related diseases, unleashing the
power within our own bodies, which is the most powerful and safest first line of defense.

*Protandim is not intended to diagnose, treat, cure or prevent any disease.

Contact: Jason & Brooke Northrup

415-223-3965
www.SlowYourAging.info