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Display SummaryBriefAbstractAbstractPlusCitationMEDLINEXMLUI ListLinkOutASN.1Related ArticlesCited in BooksCancerChrom LinksDomain Links3D Domain LinksdbGaP LinksGEO DataSet LinksGene LinksGene (OMIM) LinksGene (GeneRIF) LinksGenome LinksProject LinksGENSAT LinksGEO Profile LinksHomoloGene LinksNucleotide LinksNucleotide (RefSeq) LinksNucleotide (Weighted) LinksEST LinksEST (RefSeq) LinksGSS LinksGSS (RefSeq) LinksOMIA LinksOMIM (calculated) LinksOMIM (cited) LinksBioAssay LinksCompound LinksCompound (MeSH Keyword)Compound (Publisher) LinksSubstance LinksSubstance (MeSH Keyword)Substance (Publisher) LinksPMC LinksCited in PMCPopSet LinksProbe LinksProtein LinksProtein (RefSeq) LinksProtein (Weighted) LinksProtein Cluster LinksCited ArticlesSNP LinksSNP (Cited)Structure LinksTaxonomy via GenBankUniGene LinksUniSTS Links Show 5102050100200500Sort ByPub DateFirst AuthorLast AuthorJournalTitleSend toTextFilePrinterClipboardCollectionsE-mailOrderAll: 3Review: 0Click to change filter selection through MyNCBI. Items 1 - 3 of 3One page. 1: Eur Respir J. 2008 Aug 20. [Epub ahead of print]Related Articles, Links High MMP-9 activity characterizes pleural tuberculosis correlating with granuloma formation. Sheen P, O'Kane CM, Chaudhary K, Tovar M, Santillan C, Sosa J, Caviedes L, Gilman RH, Stamp G, Friedland JS. Universidad Peruana Cayetano Heredia, PO Box 5045, Lima, Peru; and Dept of International Health, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205, USA. Tuberculosis (TB) pleural disease is complicated by extensive tissue destruction. Matrix Metalloproteinases (MMPs) -1 and -9 are implicated in immunopathology of pulmonary and CNS TB. There are few data on MMP activity in TB pleurisy. We investigated MMP-1/-2/-9 and their specific inhibitors (TIMPs-1/-2) in tuberculous effusions, and correlated these with clinical and histopathological features.Clinical data, routine blood tests, and pleural fluid /biopsy material were obtained from 89 patients presenting with pleural effusions in a TB-endemic area. MMP-1/-2/-9 were measured by zymography or western blot, and TIMPs-1/-2 by ELISA. Pleural biopsies were examined

microscopically, cultured for AAFB and immunostained for MMP-9.Tuberculous pleural effusions contained the highest concentrations of MMP-9 compared with malignant effusions or heart failure transudates. MMP-9 concentrations were highest in effusions from patients with granulomatous biopsies, 108pg.ml(-1) (interquartile range 61-218) vs. 43pg.ml(-1) (12-83) in those with non-granulomatous pleural biopsies (p=0.001). MMP-1 and -2 were not upregulated in tuberculous pleural fluid. The ratio of MMP-9:TIMP-1 was significantly higher in TB effusions.Tuberculous pleurisy is characterized by a specific pattern of MMP-9 upregulation, correlating with the presence of granulomas and suggesting a specific role for MMP-9 in inflammatory responses in tuberculous pleural disease. PMID: 18715875 [PubMed - as supplied by publisher]

2: BMC Cancer. 2008 Aug 16;8:241.Related Articles, Links Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y, Han JX. Key Laboratory of Ministry of Health for Biotech-Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan 250062, PR China. genomeresearch@163.com BACKGROUND: There is an urgent need to discover more sensitive and specific biomarkers to improve early diagnosis and screen high-risk patients for pancreatic ductal adenocarcinoma (PDAC). Pancreatic juice is an ideal specimen for PDAC biomarkers discovery, because it is an exceptionally rich source of proteins released from pancreatic cancer cells. METHODS: To identify novel potential biomarkers for PDAC from pancreatic juice, we carried out difference gel electrophoresis (DIGE) and tandem mass spectrometry (MS/MS) to compare the pancreatic juice profiling from 9 PDAC patients and 9 cancer-free controls. Of the identified differently expressed proteins, three up-regulated proteins in pancreatic cancer juice, matrix metalloproteinase-9 (MMP-9), oncogene DJ1 (DJ-1) and alpha-1B-glycoprotein precursor (A1BG), were selected for validation by Western blot and immunohistochemistry. Serum MMP-9 levels were also detected by enzyme linked immunosorbent assay (ELISA). RESULTS: Fourteen proteins were up-regulated and ten proteins were down-regulated in cancerous pancreatic juice compared with cancer-free controls. Increased MMP-9, DJ-1 and A1BG expression in cancerous pancreatic juice were confirmed by Western blot. Immunohistochemical study showed MMP-9, DJ-1 and A1BG positively expressed in 82.4%, 72.5% and 86.3% of pancreatic cancer tissues, significantly higher than that in normal pancreas tissues. Up-regulation of DJ-1 was associated with better differentiation (p < 0.05). Serum MMP-9 levels were significantly higher in PDAC (255.14 ng/ml) than those in chronic pancreatitis (210.22 ng/ml, p = 0.009) and healthy control (203.77 ng/ml, p = 0.027). CONCLUSION: The present proteome analysis revealed MMP-9, DJ-1 and A1BG proteins as elevated in pancreatic juice from PDAC, which suggest their further utility in PDAC diagnosis and screening. This is the first time A1BG was identified as a potential biomarker in pancreatic cancer associated samples. The measurement

of serum MMP-9 might be clinically useful for PDAC diagnosis. Publication Types: Research Support, Non-U.S. Gov't PMID: 18706098 [PubMed - in process] PMCID: PMC2528014

3: Anticancer Res. 2008 May-Jun;28(3B):1757-61.Related Articles, Links Matrix metalloproteinase-9 (MMP-9) immunoreactive protein in urinary bladder cancer: a marker of favorable prognosis. Vasala K, Pkko P, Turpeenniemi-Hujanen T. Department of Oncology and Radiotherapy, Oulu University Hospital, Oulu, Finland. kaija.vasala@oulu.fi BACKGROUND: [corrected] The purpose of this study was to explore whether changes in matrix metalloproteinase-9 (MMP-9) are involved in the progression of urinary bladder cancer and whether they have any prognostic value. PATIENTS AND METHODS: Overexpression of MMP-9 was evaluated in the primary tumor of 87 urinary bladder cancer cases with immunohistochemical staining. RESULTS: Of the urinary bladder carcinomas, 38% showed an overexpression (>25%) of MMP-9 immunoreactive protein. Increased positivity for MMP-9 correlated with favorable overall survival of the urinary bladder cancer patients. The 5-year overall survival and relapse-free survival was 68% and 36% in patients showing high MMP-9 expression and 48% and 19% in patients with low (<25%) or negative MMP-9 expression (p=0.006, p=0.08, respectively). In multivariate analysis, MMP-9 overexpression seems to retain its independent prognostic value. CONCLUSION: This study shows that MMP-9 expression in urinary bladder carcinoma is associated with better prognosis. Publication Types: Research Support, Non-U.S. Gov't PMID: 18630455 [PubMed - indexed for MEDLINE]

Items 1 - 3 of 3One page. Display SummaryBriefAbstractAbstractPlusCitationMEDLINEXMLUI ListLinkOutASN.1Related ArticlesCited in BooksCancerChrom LinksDomain Links3D Domain LinksdbGaP LinksGEO DataSet LinksGene LinksGene (OMIM) LinksGene (GeneRIF) LinksGenome LinksProject LinksGENSAT LinksGEO Profile LinksHomoloGene LinksNucleotide LinksNucleotide (RefSeq) LinksNucleotide (Weighted) LinksEST LinksEST (RefSeq) LinksGSS LinksGSS (RefSeq) LinksOMIA LinksOMIM (calculated) LinksOMIM (cited) LinksBioAssay LinksCompound LinksCompound (MeSH Keyword)Compound (Publisher) LinksSubstance LinksSubstance (MeSH Keyword)Substance (Publisher) LinksPMC LinksCited in PMCPopSet LinksProbe LinksProtein LinksProtein (RefSeq) LinksProtein (Weighted) LinksProtein Cluster LinksCited ArticlesSNP LinksSNP (Cited)Structure LinksTaxonomy via GenBankUniGene LinksUniSTS Links Show 5102050100200500Sort ByPub DateFirst AuthorLast AuthorJournalTitleSend toTextFilePrinterClipboardCollectionsE-mailOrderAbout Entrez Text Version Entrez PubMed

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