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001 CELLULARNEUROSCIENCEFALL2011
MONDAY&WEDNESDAY10:00AM11:15AM GR4.428 InstructorContactInformation Dr.SvenKroener GR4.204 Phone:9728835671 kroener@utdallas.edu Officehours:MondayandWednesdayafterclass, orbyappointment.

neuronalcells, work with models describing electrical activity of neurons, particularly the role of ion channels in maintaining and altering neuronal membrane potential, describe mechanisms of synaptic transmission and synapticplasticityinducedbyexperience, describe and analyze neurophysiological recording methodsusedtoassessneuronalactivity,andlimits ofthesetechniques.

Prerequisites:None CourseDescription: Purpose of the course is to supply the basic notions in the field of cellular neuroscience, and the intellectual tools for understanding recent advances of the molecular and cellular events underlying neural signaling, synaptic transmission and plasticity. To this endthebasicmorphologyandfunctionsofneuronsand glia, describing cytology of subcellular organelles in neuronal cells, familiarizing the students with electric neuronal models, and illustrating as examples the neuromuscular junction, central synapses, synaptic integrationandplasticity StudentLearningObjectives: Aftercompletingthecourse,studentsshouldbeableto: Describe and analyze the contributions of anatomical, physiological, behavioral, pharmacological, developmental, and cell and molecular biological studies to the bases of neuroscience, describe the basic morphology and functions of neuronsandglia, use proper scientific terminology for neurotransmitters, neurotransmitter receptors, and neurotransmitter receptor/effector signaling systems, describe cytology of subcellular organelles in

RequiredTextbookandMaterials: D. Purves et al., (eds) Neuroscience 4th edition (2007)ISBN10:0878936971,and E.R. Kandel, J.H. Schwartz, and T.M. Jessell (eds) Principles of Neural Science (2000) ISBN10: 0071120009 ExamsandAssignments: Exams: Students will be evaluated with 4 tests during the semester, and a comprehensive final exam. Tests will consist of multiple choice questions and short answerquestionscoveringtheprecedinglessons. Each Test will count 30 points toward the final grade, and the Final Exam counts 90 points for a total of 210 points(seebelow). Grading Policy: Grading is based on a set of a priori criteria: 90% (or 189+ points) correct for A, ~80% (or 168+ points) for B, ~70% (or 147+ points) for C, and ~60%(or126+points)forD,lessthan~60%(126points) isautomaticallyanF.Theinstructorreservestherightto change the evaluation criteria (grade brackets) at his discretion, evenfromtesttotest.Noextratestwillbe availableforanyreason. Attendance: Attendance of classes is not mandatory butisstronglyrecommended,astestswillbebasedon material taken from the classes and will not be restricted to the topics and textbooks indicated in this syllabus, which serves predominantly as a guideline to thecourse.

Schedule:

Thisscheduleistentative.Theremaybeunforeseenoutsidefactors(e.g.schoolclosingsduetoinclementweather)that necessitateadjustmentstothisschedule,includingthedatesofreviewsandtests.Anysuchadjustmentswillbe announcedinclassand/orviaelearning. Class# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31

DATE WedAug24 MonAug29 WedAug31 MonSept5 WedSept7 MonSept12 WedSept14 MonSept19 WedSept21 MonSept26 WedSept28 MonOct3 WedOct5 MonOct10 WedOct12 MonOct17 WedOct19 MonOct24 WedOct26 MonOct31 WedNov2 MonNov7 WedNov9 MonNov14 WedNov16 MonNov21 WedNov23 MonNov28 WedNov30 MonDec5 FriDec9 Introduction

TOPIC Structureofneurons GliaandNeurons NoClassLaborDay MembranePotential Actionpotential Actionpotential Review Test1 Passivemembraneproperties Ionchannelsandtransporters Synaptictransmission Synaptictransmission Activityinneuronalnetworks Review Test2 Neurotransmittersandtheirreceptors Neurotransmittersandtheirreceptors Neurotransmittersandtheirreceptors MolecularSignalingwithinNeurons Review Test3 MolecularSignalingwithinNeurons MolecularSignalingwithinNeurons synapticplasticity(LTPLTD) synapticplasticity(LTPLTD) Spiketimingdependentplasticity Review Test4 Review FINALExam8:00AM

ASSIGNMENTS PurvesCh.1;KandelCh.1 KandelCh.4,5 PurvesCh.1;KandelCh.2 PurvesCh.2;KandelCh.7 PurvesCh.3;KandelCh.9 PurvesCh.3;KandelCh.9 PurvesCh.3;KandelCh.8 PurvesCh.4;KandelCh.6 PurvesCh.5;KandelCh.10,11,14 PurvesCh.5;KandelCh.10,11,14,16 KandelCh.46 PurvesCh.6;KandelCh.15 PurvesCh.6;KandelCh.15 PurvesCh.6;KandelCh.15 PurvesCh.7;KandelCh.13 PurvesCh.7;KandelCh.13 PurvesCh.7;KandelCh.13 PurvesCh.8;KandelCh.63 PurvesCh.8;KandelCh.63 PurvesCh.8

Alldescriptionsofthedidacticmaterialandthe timelinesaresubjecttochangeatthediscretionofthe instructor.

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disability. For example, it may be necessary to remove classroom prohibitionsagainsttaperecordersoranimals(inthecaseofdogguides)for students who are blind. Occasionally an assignment requirement may be substituted(forexample,aresearchpaperversusanoralpresentationfora student who is hearing impaired). Classes enrolled students with mobility impairmentsmayhavetoberescheduledinaccessiblefacilities.Thecollege oruniversitymayneedtoprovidespecialservicessuchasregistration,note taking,ormobilityassistance. Itisthestudentsresponsibilitytonotifyhisorherprofessorsoftheneedfor suchanaccommodation.DisabilityServicesprovidesstudentswithlettersto present to faculty members to verify that the student has a disability and needsaccommodations.Individualsrequiringspecialaccommodationshould contacttheprofessorafterclassorduringofficehours. ReligiousHolyDays The University of Texas at Dallas will excuse a student from class or other requiredactivitiesforthetraveltoandobservanceofareligiousholydayfor a religion whose places of worship are exempt from property tax under Section11.20,TaxCode,TexasCodeAnnotated. The student has to notify the instructor or activity sponsor as soon as possible regarding the absence, in advance of the assignment or test. The student, so excused, will be allowed to take the exam or complete the assignmentwithinareasonabletimeaftertheabsence,atdiscretionofthe instructor, up to a maximum of one week. A student who notifies the instructor and completes any missed exam or assignment may not be penalized for the absence. A student who fails to complete the exam or assignmentwithintheprescribedperiodmayreceiveafailinggradeforthat examorassignment. Ifastudentoraninstructordisagreesaboutthenatureoftheabsence[i.e., for the purpose of observing a religious holy day] or if there is similar disagreementaboutwhetherthestudenthasbeengivenareasonabletime tocompleteanymissedassignmentsorexaminations,eitherthestudentor the instructor may request a ruling from the chief executive officer of the institution, or his or her designee. The chief executive officer or designee must take into account the legislative intent of TEC 51.911(b), and the studentandinstructorwillabidebythedecisionofthechiefexecutiveofficer ordesignee. Thesedescriptionsandtimelinesaresubjecttochangeatthediscretionof theinstructor.