NEWS

Issue two May 2006

DEAR AVIAN PROFESSIONALS,

Welcome to the 2nd issue of the Lohmann Newsletter AviPro News. Thanks to the positive response of the readers of our 1st issue, we have now been able to establish this new communication tool as a steady and recurring publication. AviPro News will be published 3 times a year in January, May and September. For the January issue we await your contribution and ideas till the end of November, for the May issue till the end of March and for the publication in September till the end of July. Please understand this as a cordial invitation to actively take part in the development of this publication. In this issue, we brief you about some new developments at Lohmann, among others new products such as AviPro IBD XTREME, our intermediate plus Gumboro vaccine; our water stabiliser AviBlue; and new Avian Professionals which are joining our team. As our company truly grows, we must make sure that information is quickly and clearly passed around. A better support for all Avian Professionals. Yours sincerely,

Anna-Christina Riebau
Marketing Poultry Vaccines, Lohmann Animal Health GmbH & Co. KG

NEW WATER CONTENTS Events/visits STABILISER

With vaccination procedures becoming so important on the delivery of efficacious vaccines to highly specialised and often costly birds, water quality, water distribution and ock behaviour must be therefore ensured. AviBlue is an effervescent granulate with an improved solubility formula, reducing negative effects of tap water and visualising the ow of water in the drinking line. AviBlue was designed in conjunction with LAH Director of Production and Process Development Dr Klaus-Uwe Schwarz, Mr Helge Nestler from New Business Development at the Feed Additives Department and Director of Technical Services Dr Michael Iburg.
2 3 3

Technical training in Cuxhaven LAH Gumboro Seminar in the Netherlands Venezuelan visitors at LAH headquarters

Products
4 4 5 AviPro IBD XTREME AviPro 108 FC4 GOLD Switching back from hot vaccines to AviPro Precise

Avian Professionals
6 6 6 6 6 7 7 7 Axel Foellmer Dr Rita Weber Dr Ivan Alvarado & Dr Mariano Salem Wendy Miller-Hackett Dr Lindolfo Rocha Beata Chodakowska Nadine Mahler & Andrea Kienitz Bill Nash

Dr Klaus-Uwe Schwarz

It is a simple product that protects the administration of viral and bacterial live vaccines, enabling a better utilisation of each dose and vaccine titre and a longer maintenance of titre throughout the vaccination procedure.

Whats new?
8 8 8 New caps for the Lohmann live vaccines Time for T New brochures available

NEWS
page 2 issue two

NEW WATER STABILISER

Dr Schwarz explains that AviBlue contains a neutralising agent which buffers the negative effects of hard water or residues of chlorination on vaccination with live virus or bacteria in drinking water for poultry. The deep blue colour given to the vaccine water by AviBlue allows a visualisation of water ow in the drinking line, so the vaccination crew can ensure a homogenous distribution of vaccine throughout the ock, and even on the birds, through observation of stained tongues or crops. The effervescent granules of AviBlue dissolve quickly and autonomously in the drinking water, therefore AviBlue outmatches other granulated products. AviBlue comes as a practical aid to ensure the better utilisation of our live vaccines and protect the investment on high-quality immunogenic products from Lohmann Animal Health. AviBlue is not yet available to all markets worldwide. Currently the product is being utilised in test markets.

The fast dissolving granules of AviBlue

Events/visits

TECHNICAL TRAINING SESSION 2005 IN CUXHAVEN OR HOW TO BUILD A DYKE

In October 2005 the department of Marketing Poultry Vaccines invited the technical service people of distributors and LAH foreign representative offices to 3 days of technical training and discussion in Cuxhaven. them the chance to benefit from the experience of older colleagues as well as to give scientific questions and the exchange of knowledge and information an adequate forum. The 28 participants from more than 20 different countries were exposed to informative and interesting presentations on diseases, products, positioning and

Dr van Dijk explains the meaning of vaccination by using the dyke metaphor

28 participants from all over the world attended the Technical Training Session 2005 in Cuxhaven After a hard days work, participants enjoy dinner at the Ritzebtteler Schloss

The aim of the conference was to give new people a more detailed and intensive introduction to the products and to give

vaccination programmes by LAH and LAHI technical support, marketing and sales

people. Every presentation was followed by several questions or raised topics that lead to a lively debate, so that the planned discussion time was more than perfectly lled. Not only thanks to the speakers and their thoroughly prepared presentations, but also to the well organised social programme, the seminar was a successful event and a memorable experience.

NEWS
page 3 issue two

Events/visits

LAH GUMBORO VACCINE SEMINAR IN THE NETHERLANDS

A Gumboro Vaccine Seminar for veterinary clients from the Netherlands and Belgium was organised in early November 2005 by Roland Bronneberg (technical support and sales consultant, LAH the Netherlands). The Moreover, this setting was also chosen for creating a relaxed atmosphere to exchange practical experiences and information regarding the Dutch and Belgian poultry (vaccine) market. On Friday afternoon, therefore, clients were offered to join the entertainment programme, which besides quad racing, bow-and-arrow shooting and team-building games, included a dinner afterwards. On Saturday morning, the actual seminar started and the following topics were presented and discussed: Positioning and use of Gumboro vaccines in general by Roland Bronneberg Data from eld trials with broiler ocks in Germany, comparing performance after vaccination with AviPro GUMBORO VAC and a competitor intermediate IBD vaccine, by Dr Michael Iburg (LAHs Technical Support Department)
LAHs intermediate Gumboro vaccines: AviPro Gumboro vac and AviPro Precise

The use of and experience with hot Gumboro vaccines, as well as AviPro GUMBORO VAC and AviPro PRECISE under eld conditions in a poultry-dense area of Germany, by Dr Hermann Block (specialised poultry practitioner in Germany). Dr Thijs van Dijk, from LAHs Marketing Department, was chairman during the seminar. Overall, discussions were numerous, interesting and refreshing, and from various clients point of views. LAH is showing its new face, also in the Netherlands and Belgium working with the Avian Professionals. *Formerly TAD Gumboro vac lyo and TAD Gumboro vac forte.

Participants of the Gumboro Vaccine Seminar

main reason for organising this event was to provide customers with updated technical and practical information on LAHs Gumboro vaccines: AviPro GUMBORO VAC* and AviPro PRECISE*.

Events/visits

VENEZUELAN VISITORS AT LAH HEADQUARTERS

From 29 November to 2 December a number of Venezuelan integrators, veterinarians and representatives from authorities visited the Cuxhaven headquarters. The group was accompanied by sales manager Adriana Baruch and technical representative Dr Beatriz Cardoso from Lohmann Animal Health Brazil as well as Rafael Guerra and Virginia Aizpurua from the Venezuelan distributor Binveca. During their stay, the group was not only exposed to an introduction to Lohmann Animal Healths company prole by Anna-Christina Riebau, but also got a deeper insight into the products AviPro SALMONELLA VAC E, AviPro SALMONELLA VAC T and AviPro THYMOVAC from presentations by Dr Thijs van Dijk, Dr Anne Vits and Eduardo Bernardi. Binveca is currently in the process of registering these vaccines for the Venezuelan market. Dr Anne Vits, who lives in Bremen, volunteered to give our guests an exciting and interesting tour through her city. Besides the very valuable technical information the Venezuelans received during their stay in Germany, they also had the chance to be introduced to a typical German custom in Bremen the Christmas market with Glhwein.

NEWS
page 4 issue two

Products

IBD XTREME A NEW VACCINE TO COMBAT vvIBD

virulent and able to break through relatively high levels of maternally derived antibodies (MDAs). The young chicks are exposed to a very early eld challenge. Intermediate vaccines cannot be given early enough to protect the chicks. In the time the eld virus is already attacking the chicks, they will still be neutralised by the high levels of MDAs due to their lower breakthrough titre. Only intermediate plus vaccines are able to take early enough to protect the chicks against this early eld challenge. The new intermediate plus vaccine from Lohmann Animal Health against Infectious Bursal Disease, AviPro IBD XTREME, is the right choice to combat vvIBD successfully. With a virus neutralisation (VN) breakthrough titre of approximately 9, it is possible to administer it early enough to protect the young chicks against the early challenge of vvIBD and thereby reduce the mortality in the ock caused by the very virulent virus. AviPro IBD XTREME is a lyophilised live intermediate plus vaccine against IBD containing the Winterfield
Vaccination with an intermediate vaccine
14,0 12,0 10,0 8,0

Vaccination too early Correct time of vaccination Vaccination too late

Titre (log2)

6,0 4,0 2,0 0,0 0 10 20 30 40

IBDV challenge Age in days

Vaccination with an intermediate plus vaccine

14,0 12,0 10,0 8,0

Correct time of vaccination with a HOT strain Vaccination too late Vaccination too late

Titre (log2)

6,0 4,0 2,0 0,0 0 10 20 30 40

vvIBDV challenge Age in days

2512 strain. The vaccine can be applied via the drinking water, by spray or eye drop. Currently, AviPro IBD XTREME is available in the USA and under registration in several other countries. Distributors and end users are very excited with the results and promises of the new product. Things are just getting warm and there is a lot more to come!

LAHs hot answer to vvIBD

Since the late 1980s, the acute form of Infectious Bursal Disease (IBD), induced by the very virulent IBD virus (vvIBDV) a pathotypic variant of IBDV caused significant economical losses to the poultry industry in several countries. In the case of vvIBD, the virus is extraordinarily

Products
Protection against mortality in ducks after challenge with Pasteurella multocida

108 FC4 GOLD PROVES SUCCESS IN THAI DUCKS

AviPro 108 FC4 GOLD, a bacterin against Fowl Cholera containing four different strains of Pasteurella multocida in a novel WOW adjuvant (water-in-oil-in-water) was tested for ducks at the Kasetasart University, in Nakhornpathom, Thailand. The purpose of the trial was to verify efficacy of AviPro 108 FC4 GOLD against a local strain of Pasteurella isolated from an outbreak in ducks in Thailand. One group of 25-day-old ducklings was vaccinated intramuscularly with an autogenous vaccine (produced by the Thai Ministry of Agriculture). Another group was vaccinated intramuscularly (0.25 ml) with the LAH vaccine AviPro 108 FC4 GOLD. At 51 days of age, all groups were inoculated with an intranasal challenge of 0.2 ml of 105 CFU/ml of the local strain. Efficacy was measured as protection against mortality.

100 % 90 % 80 % 70 % 60 % 50 % 40 % 30 % 20 % 10 % 0%

Controls (non-vaccinated)

Autogenous vaccine

AviPro 108 FC4 GOLD

The Lohmann vaccine AviPro 108 FC4 GOLD proved to protect against mortality due to challenge by the Thai strain of Pasteurella multocida. This South East Asian trial adds to the features of this innovative product, already used in Central Europe against Pasteurella multocida outbreaks in waterfowl.

NEWS
page 5 issue two Pasteurella vaccination finally made safe and easy

AviPro 108 FC4 GOLD is one of the new inactivated bacterins from Lohmann Animal Health (together with AviPro 101 Coryza GOLD), which take advantage of the novel WOW adjuvant technology. This special emulsication procedure has allowed us to produce a bacterin utilising water and oil ingredients for adjuvants in a procedure that ensures efficacy but reduces the likelihood of site lesions and reactions. Whereas traditional inactivated vaccines take the water in oil emulsions, utilising at

least 70 % of mineral oil, this new WOW technology reduces the oil proportion to less than 50 % and changes the exterior phase into water. Advantages of the WOW emulsion in a bacterin include lower tissue reactivity; it prevents losses from prostration, stiff necks and pain; no abscesses or granulomas on the injected site; no residues at slaughter and an easier uidity on the operation. For protection of chickens against Fowl Cholera, AviPro 108 FC4 Gold is the rst of its type to be licensed for intra muscular injection. This method provides greater ease of application, allowing for

Antigens in water-in-oil-in-water

one less person on the vaccination crew with reduced risk of injury to the bird and to the personnel (self-injection). Breast vaccination is a less demanding operation, which also costs less.

Products

SWITCHING BACK FROM HOT VACCINES TO PRECISE

% Mortality (Average of 46 days slaughter on both groups)

AviPro PRECISE is ideal for the follow-up of hot vaccines, in order to improve productivity. The practice of utilising hot vaccines to combat vvIBDV is common for the control of these early eld challenges that break through higher levels of maternal antibodies. However, broiler performance may be deteriorated by bursal damage and immuno-suppression. Once the load of eld challenge is reduced through the continuous use of hot vaccines, focus can switch back to improvement of broiler performance. In order to compare production results of broilers vaccinated with a hot vaccine with those birds vaccinated with an intermediate vaccine, a eld trial was conducted in collaboration with a broiler integration in Turkey. The farms included in the trial had a long history of using hot IBD vaccines on their premises, and one of the questions of this trial was to determine whether switching from a hot vaccine to an intermediate one would increase protability of the production. A total of 146,500 birds (Ross 508) were housed on farms with a history of IBD outbreaks and long use of hot vaccines. One group of 5 houses was vaccinated with an intermediate IBD vaccine (AviPro PRECISE), and another group of 6 houses with a hot IBD vaccine (from competitor). Under those conditions, AviPro PRECISE performed better than the competitor hot vaccine, both with regards to mortality and feed conversion, making the (calculated) European Performance Index (EPEF) 13.7 points higher for the LAH vaccine.

7,0 6,0 5,0 4,0 3,0 2,0 1,0 0,0

Hot IBD Vaccine Competitor

Intermediate Vaccine AviPro Precise

Feed Conversation Rate (kg Feed/kg Meat)

1,90 1,89 1,88 1,87 1,86 1,85 1,84 1,83 1,82 1,81 1,80 1,79 1,78 1,77 1,76 1,75

Hot IBD Vaccine Competitor

Intermediate Vaccine AviPro Precise

European Performance Index

320 310 300 290 280 270 260 250 240 230 220 210 200

Hot IBD Vaccine Competitor

Intermediate Vaccine AviPro Precise

NEWS
page 6 issue two

Avian Professionals

MANAGING DIRECTOR FOR THE ASEAN COUNTRIES

Axel Foellmer has been appointed managing director of Lohmann Animal Healths ASEAN operations, based at the companys regional head office in Bangkok, Thailand. His main task will be to develop key and emerging markets for Lohmanns extensive range of poultry vaccines.

POULTRY DISEASE SPECIALIST

Dr Rita Weber has joined Lohmann Animal Health as a specialist for poultry diseases. Based in Cuxhaven, she will be involved in eld trials and provide technical support for customers. A graduate from the University of Veterinary Medicine, Hanover, her career has involved posts at the Clinic for Poultry at that university and at the Institute of Food Science at the University of Gieen.

Axel Foellmer

Dr Rita Weber

After graduating from the University of Bochum, Germany, Mr Foellmer held a number of senior management and marketing posts with international companies and has worked extensively in Asia.

NEW TECHNICAL SERVICE VETERINARIANS FOR THE NAFTA REGION

Dr Ivan Alvarado has joined Lohmann Animal Health International (LAHI) as a technical service veterinarian. Based in Athens, Ga., he is providing technical support for customers in the NAFTA region. Dr Alvarado holds a Ph.D. in medical microbiology from the University of Georgia and a Doctor of Veterinary Medicine from the University of Tolima in Colombia.
Dr Ivan Alvarado Dr Mariano Salem

Dr Mariano Salem was recently hired as Technical Service Manager for LAHI. Based in Salisbury, Maryland, he will strengthen our technical service team with his long-time experience and knowledge in the poultry industry, on providing technical support to the customers. Dr Salem holds a M.S. from the University of Pennsylvania and a DVM from the Universidad Autnoma de Tamaulipas, Mexico. He worked several years for vaccine, diagnostic, pharmaceutical and poultry production companies in Latin America. He is mostly recognized for more than 15 years service at the University of Delaware, Lasher Laboratory, where he held various positions including 6 years as the Director.

His previous experience includes working as a veterinary supervisor for broiler breeders and commercial layers for companies in Colombia.

NEW SALES MANAGER FOR BRAZIL

Dr Lindolfo Rocha has been appointed sales manager for the Brazilian operations of Lohmann Sade Animal, based at the companys office in So Paulo. Dr Rochas experience in the poultry eld covers extensive contact with the Brazilian industry, rst as a veterinarian at an avian pathology laboratory and later on the sales team of Idexx, being responsible for poultry products. His technical skills and contacts will be used to conduct the sales for the Brazilian market.
Dr Lindolfo Rocha

NEW ORDER COORDINATOR FOR LAHI

Wendy Miller-Hackett is responsible for expediting orders and shipments within the United States as well as the NAFTA region, which includes Canada and Mexico, as well as Puerto Rico.

Wendy Miller-Hackett

NEWS
page 7 issue two

LOHMANN ANIMAL HEALTH LAH APPOINTED TWO NEW APPOINTS VETERINARY SURGEON SALES ASSISTANTS IN POLAND Nadine Mahler has been appointed
Lohmann Animal Healths team in Poland is being strengthened with the appointment of veterinary surgeon Beata Chodakowska as sales manager for poultry vaccines. Based at the companys office in Warsaw and reporting to European sales manager Matthias Mangels, she will provide support to the companys extensive range of vaccines.
Nadine Mahler

sales assistant for Eastern Europe and Africa. She is based at LAHs headquarters in Cuxhaven and works closely with area manager Jens Lth. Before joining the sales department, Ms Mahler nished three years of vocational training at Lohmann Animal Health. Andrea Kienitz, who is a trained foreign language correspondence clerk with 11 years experience in working for an export company, joined the Lohmann team at the end of last year. Ms Kienitz is also based in Cuxhaven and works closely with area manager Matthias Mangels, who is in charge of the European countries.

Beata Chodakowska

After qualifying at the Agricultural University in Warsaw, Ms Chodakowska gained wide experience with animal health companies both in Poland and Thailand.

Andrea Kienitz

BILL NASH
Bill Nash, consultant veterinary surgeon to Lohmann Animal Health has died, aged 49, at his home in Southampton following a long illness. Bill was widely known throughout the poultry industry for his specialist expertise, both on-farm in a troubleshooting role, and with regulatory authorities. He was responsible for licensing two of the UKs most popular salmonella vaccines for poultry TAD Salmonella vac E and TAD Salmonella vac T (now AviPro SALMONELLA VAC E and T). They were the rst live, oral salmonella vaccines to be licensed in the UK, paving the way for licensing in other EU countries. These offer great welfare benets by avoiding the need for farmers to inject millions of chickens. Bill, who qualied at the Royal Veterinary College, London, where he gained a distinction in biochemistry, had a distinguished career, encompassing general practice and senior posts with pharmaceutical companies. He also worked closely with the UK governments Veterinary Laboratories Agency, Weybridge, Surrey, where he was involved in registration of vaccines and had responsibility for releasing licensed products. As well as his clear-thinking and ability to cut through complex problems, Bill will be remembered for his down-to-earth professional approach and great sense of humour.

NEWS
page 8 issue two

Whats new ?

NEW CAPS FOR THE LOHMANN LIVE VACCINES

LAH International Poultry Vaccines
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LV :1503-D

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Whats new?

NEW BROCHURES AVAILABLE

Lohmann Animal Health extended its range of English brochures by adding folders on AviPro 101 CORYZA GOLD, AviPro 108 FC4 GOLD, AviPro 301 ND-IB-IBD and AviPro 401 ND-IB-IBD-REO. In addition to this English range Information material in several languages is waiting for you After already being able to introduce the new brochures of Lohmann Animal Health vaccines in our last issue of AviPro News, we are proud to announce that the brochures are now available in several languages. For our Polish customers, the brochures on the products AviPro SALMONELLA VAC E and T, AviPro PRECISE, AviPro THYMOVAC and the Information-Sheets Differentiating Field Isolates from Vaccine Strain and Practical Vaccination Points are available in Polish through our office in Warsaw. Through our Brazilian office Lohmann Sade Animal in So Paulo, Portuguese versions of AviPro SALMONELLA VAC E and Differentiating Field Isolates from Vaccine Strain as well as a Spanish version of AviPro SALMONELLA VAC E are distributed. Spanish versions of the whole range of brochures will be printed by Lohmann Animal Health International. Last but not least there is also a Chinese AviPro SALMONELLA VAC E brochure ready to be given out from our Representative Office in Beijing.

To make this modication as undisturbing as possible, new colour code tables for vaccines from Germany (LAH) and the USA (LAHI) are available on request, which in addition are aids to identify the new AviPro names of the vaccines.

Whats new ?

TIME FOR T
The success of TAD Salmonella vac T (soon AviPro Salmonella vac T), our live vaccine against Salmonella Typhimurium, is likely to spread from countries which are already utilising it on a regular basis towards a more broad range of areas in the European Union. In December 2005, the Mutual Recognition procedure for the registration of TAD Salmonella vac T was nished, with the approval of all countries requested. The list includes Italy, Spain, the Netherlands, Greece, Portugal, Belgium, Slovakia and the Czech Republic. For Italy, in particular, this is a major breakthrough, as no other live vaccines for Salmonella Typhimurium were allowed on the market. A complete safety prole and the support of easy laboratory techniques (such as AviPro Plate) for the differentiation of eld and vaccine strains were all instrumental for the approval of this vaccine under the strict control of European Veterinarian Authorities.

NEWS CREDITS
Publisher: Lohmann Animal Health GmbH & Co. KG Heinz-Lohmann-Strae 4 27472 Cuxhaven Germany www.lah.de Editor: Anna-Christina Riebau anna-christina.riebau@lah.de