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    This study developed a prolonged release formulation of the pain medication tramadol using Kollidon SR, a polymer known to retard drug release from matrix tablets. Tablets containing different ratios of tramadol and Kollidon SR were prepared and tested, with a 1:0.5 ratio exhibiting a rapid initial burst release while higher polymer ratios extended release over time. The optimal formulation most closely matched the dissolution profile of the commercial product Contramal. Testing found the release was consistent under different pH and agitation conditions and followed Higuchi kinetics. Short term stability studies indicated this formulation remained stable.

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    This study developed a prolonged release formulation of the pain medication tramadol using Kollidon SR, a polymer known to retard drug release from matrix tablets. Tablets containing different ratios of tramadol and Kollidon SR were prepared and tested, with a 1:0.5 ratio exhibiting a rapid initial burst release while higher polymer ratios extended release over time. The optimal formulation most closely matched the dissolution profile of the commercial product Contramal. Testing found the release was consistent under different pH and agitation conditions and followed Higuchi kinetics. Short term stability studies indicated this formulation remained stable.

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    46 views1 page

    1331 Ab

    Uploaded by

    Preeti Bhadke
    This study developed a prolonged release formulation of the pain medication tramadol using Kollidon SR, a polymer known to retard drug release from matrix tablets. Tablets containing different ratios of tramadol and Kollidon SR were prepared and tested, with a 1:0.5 ratio exhibiting a rapid initial burst release while higher polymer ratios extended release over time. The optimal formulation most closely matched the dissolution profile of the commercial product Contramal. Testing found the release was consistent under different pH and agitation conditions and followed Higuchi kinetics. Short term stability studies indicated this formulation remained stable.

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    International Journal of Pharmaceutical Sciences and Nanotechnology

    Volume 4 Issue 1 April-June 2011

    International Journal of Pharmaceutical Sciences and Nanotechnology Volume 4 Issue 1 April June 2011

    Research Paper Development of Prolonged Delivery of Tramadol and Dissolution Translation by Statistical Data Treatment
    B.P. Punit*, S.B. Bhavesh and K.S. Pragna
    K.B. Institute of Pharmaceutical Education and Research, Gandhinagar, India.
    The present study was carried out to fabricate a prolonged design for tramadol using Kollidon SR (Polyvinyl acetate and povidone based matrix retarding polymer). Matrix tablet formulations were prepared by direct compression of Kollidon SR of a varying proportion with a fixed percentage of tramadol. Tablets containing a 1:0.5 (Drug: Kollidon SR) ratio exhibited a rapid rate of drug release with an initial burst effect. Incorporation of more Kollidon SR in the matrix tablet extended the release of drug with subsequent minimization of the burst effect as confirmed by the mean dissolution time, dissolution efficiency and f2 value. Among the formulation batches, a direct relationship was obtained between release rate and the percentage of Kollidon SR used. The formulation showed close resemblance to the commercial product Contramal and compliance with USP specification. The results were explored and explained by the difference of micromeritic characteristics of the polymers and blend of drug with excipients. Insignificant effects of various factors, e.g. pH of dissolution media, ionic strength, speed of paddle were found on the drug release from Kollidon-SR matrix. The formulation followed the Higuchi kinetic model of drug release. Stability study data indicated stable character of Batch T6 after short-term stability study.

    ABSTRACT:

    KEYWORDS: Tramadol; Kollidon SR; Dissolution efficiency; CONTRAMAL; Model fitting

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