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Pathophysiology (Symptoms) Decreased urine output, although occasionally urine output remains normal Fluid retention, causing swelling in your legs, ankles or feet Respiratory dyspnea, tachypnea, uremic pneumonitis, lung crackles, Kussmaul respirations, and pulmonary edema Drowsiness Fatigue Confusion Nausea Seizures or coma in severe cases Chest pain or pressure Irregularities in the heartbeat which can be severe and life-threatening. This is from increases in the potassium level. Skin decreased skin turgor, yellow cast to skin, dry, pruritus, bruising, and uremic frost (late) Sometimes acute kidney failure causes no signs or symptoms and is detected through laboratory tests done for another reason. Etiology (Cause) Diseases and conditions that slow blood flow to the kidneys Prerenal ARF is caused by Blood loss, Blood pressure medications, Heart attack, Heart disease, Infection, Liver cirrhosis, Nonsteroidal antiinflammatory drugs, such as aspirin, ibuprofen and naproxen, Severe allergic reaction (anaphylaxis), Severe burns, and Severe dehydration Diseases and conditions that may damage the kidneys Intrarenal, or intrinsic, ARF is caused by Blood clots in the veins and arteries in and around the kidneys, Cholesterol deposits that block blood flow in the kidneys, Glomerulonephritis, Hemolytic uremic syndrome, Infection, Lupus, Medications, Multiple myeloma, Scleroderma, Vasculitis, and alcohol, heavy metals and cocaine Diseases and conditions that block urine from leaving the body Postrenal (postobstructive) ARF is caused by Bladder cancer, Blood clots in the urinary tract, Cervical cancer, Colon cancer, Enlarged prostate, Kidney stones, Nerve damage involving the nerves that control the bladder, and Prostate cancer Being hospitalized, especially for a serious condition that requires intensive care Blockages in the blood vessels in your arms or legs (peripheral artery disease) Diagnostic Tests Urine output measurements. A daily record of intake, output, and weights assists the physician in making treatment decisions. Urinalysis. Granular muddy-brown casts suggest tubular necrosis; tubular cells or tubular cell casts suggest acute tubular necrosis (ATN); reddish-brown urine and proteinuria suggest acute glomerular nephritis; presence of red blood cells may indicate glomerular nephritis; and white blood cells may indicate pyelonephritis Blood tests. A sample of your blood may reveal rapidly rising levels of urea and creatinine two substances used to measure kidney function. 24-hr urine creatinine. Acute damage to the kidney limits ability to clear creatinine, causing a 50% decrease. Urine sodium Prerenal and sometimes intrarenal leads to sodium retention whereas postrenal leads to sodium loss in urine Imaging tests. Imaging tests such as ultrasound and computerized tomography (CT) may be used. Kidney Biopsy. In certain situations, your doctor may recommend a kidney biopsy to remove a small sample of kidney tissue for laboratory testing. To remove a sample of kidney tissue, your doctor may insert a thin needle through your skin and into your kidney. Treatment Treating the underlying cause of your kidney failure Treatment for acute kidney failure involves identifying the illness or injury that originally damaged your kidneys. Intravenous Fluids or Diuretics depending on if your condition is causing fluid retention or lack of fluids. Medications to control blood potassium. Doctor may prescribe calcium, glucose or sodium polystyrene sulfonate (Kayexalate) to prevent the accumulation of high levels of potassium in your blood. Dialysis to remove toxins from your blood. Choose lower potassium foods. Your dietitian may recommend that you choose lower potassium foods at each meal. Avoid products with added salt. Lower the amount of sodium you eat each day by avoiding products with added salt Complications Permanent kidney damage. Occasionally, acute kidney failure causes permanent loss of kidney function, or end-stage renal disease. People with end-stage renal disease require either permanent dialysis a mechanical filtration process used to remove toxins and waste from your body or a kidney transplant to survive. Death. Acute kidney failure can lead to loss of kidney function and, ultimately, death. The risk of death is highest in people who had kidney problems before experiencing acute kidney failure. Metabolic acidosis Hyperkalemia Pulmonary edema Seizures Hypertension Cardiac dysrhythmias