Anup Bajracharya

QA Officer, Quest Pharmaceuticals (P)Ltd

anuuu8@hotmail.com

CAPPING AND LAMINATION

S.No Reasons Remedies

1. Air entrapment in the tablet among granules or By pre-compression, Reducing final
among compression, Minimizing
particles tableting rate

2. Deformational properties of formulation during Increasing stress relaxation time

and after
compression

3. Improper/Deep concave punches Better to use flat punches

4. Over dried granules (Due to lack of cohesion)
5. Improper tooling:
Ø Concave
edges of punches turning claw shaped
Ø Greater radius of curvature of punch face
Ø Dies developing a wear ring shape
Ø Improper adjustment of sweep off blade
Ø Less rise of lower punch during ejection of
tablet
By maintaining moisture levels using
hygroscopic materials
like MC (Methyl Cellulose), Sorbitol, PEG 4000
(Polyethylene glycol) etc.
Proper tooling:
Ø Checking of punches and replacing them
Ø Proper checking and replacing them
Ø Turning the die over so that compression
occurs in an
unworn area above ring
Ø Proper setting of sweep off blade & lower
punch rise

6. Poor compressibility observed during direct Relative compressibility is to be maintained

compression
technique
 Anup Bajracharya
QA Officer, Quest Pharmaceuticals (P)Ltd
anuuu8@hotmail.com

PICKING AND STICKING

Picking:-

!
" !
" #!
"

$!
" %!

& " '

(
)

Sticking:-

Adherence of tablet material to the die walls resulting in chipping of tablet

edges producing rough edges and causing the lower punches uneasy to move resulting
in damage of cam tracks and punch faces
:
• Presence of low melting point substances in the formula ex. stearic
acid, PEG (Polyethylene glycol) etc , which gets soften due to compressive heat
• Excessive moisture in the granules
:
• Partial or complete substitution of low melting point components with
high melting point materials in the formula
• Proper drying of the granules to remove excessive moisture
 Anup Bajracharya
QA Officer, Quest Pharmaceuticals (P)Ltd
anuuu8@hotmail.com

WEIGHT VARIATION

Granule size and size distribution

* "

) ' +
, - '

Poor flow

0 "

'

Poor mixing

* /

* 1 /
 Anup Bajracharya
QA Officer, Quest Pharmaceuticals (P)Ltd
anuuu8@hotmail.com

/ 1 /

Punch variation

) 1

'

Hardness variation

MOTTLING

) 1

2 + -
#

3
)
 Anup Bajracharya
QA Officer, Quest Pharmaceuticals (P)Ltd
anuuu8@hotmail.com

(
/
*

4 '

DOUBLE IMPRESSION