Review of Literature

The following methods have been reported for the estimation of LEVO and PPH individually and in combination with other drugs: 1. Selvan PS., Gopinath,.Sarvanand R, and. Gopal VS, have developed a method for simultaneous determination of Levocetrizine, Ambroxol, Phenylpropanolamine and paracetamol in combination dosage forms by RP-HPLC method.(1) 2. Nalini CN, Kavitha K, have developed a method for simultaneous determination of pseudoephedrine hydrochloride and cetrizine hydrochloride by Reverse Phase High Performance Liquid Chromatography.(2) 3. Margherita SB, Michel P.,Jacques kaise,laura maier,Eugene baltes,Catherine have Absorption, Distribution, metabolism and excretion of [14C] Levocetrizine, the R enantiomer of cetrizine, in healthy volunteers.(3) 4. Panda SK. Sharma KS. Simultaneous spectrophotometric estimation of

phenylpropanolamine HCl, bromhexine HCl and chlorpheniramine maleate(4) 5. Cavazzutti,G, developed a method of Simultaneous Determination of Buzepide, Phenylpropanolamine, and Clocinizine in Pharmaceutical Preparations by Ion-Pair Reversed-Phase HPLC.(5) 6. Gagliardi,L.Cavazzutti,G.de Orsi,D.Rotunno,T.Tonelli,D. HPLC Determination of Aminopropiophenone as an Impurity in Phenylpropanolamine Bulk Drug and Pharmaceutical Formulations.(6) 7. Henry JA. Abstracts of the European Association of Poisons Centres and Clinical Toxicologists XXV International Congress.(7) 8. Kenichiro N. Saori K. Amal K. Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC.(8) Dept. of Pharmaceutical analysis | PESCP 41

Review of Literature

9. Vasudevan,M .Ravisankar,S .Sathiyanarayanan,A. Chandan,RS. Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC.(9) 10 Yun H. Young JY. The Detection Method of Phenylpropanolamine in Pharmaceuticals by High Performance Liquid Chromatography(HPLC)(2 11. Piotr Kowalski * AP has done the Comparison of HPLC and CE methods for the determination of cetirizine dihydrochloride in human plasma samples17 12. M.R. Moritaa c,D. Bertona, R. Boldina, F.A.P. Barrosa, E.C. Meurera, A.R. Amaranteb, D.R. Camposc, S.A. Calafattia, R. Pereirab, E. Abib Jr.b, c and J. Pedrazolli Jr.a. Determination of levocetirizine in human plasma by liquid chromatography electrospray tandem mass electroscopy

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Review of Literature

References: 1. Selvan., Gopinath P, Sarvanand R, Gopal V. simultaneous determination of

Levocetrizine, Ambroxol, phenylpropanolamine and paracetamol in combined dosage forms by RP-HPLC method. J: of Chem. 2006;18:2591-6.

2.

Nalini C, Kavitha K. Simultaneous determination of pseudoephedrine hydrochloride

and cetrizine hydrochloride by Reverse Phase High Performance Liquid. Indian J. 2006;68(1):95-7.

3. Margherita S, Michel P, Jacques K, Laura M, Eugene B. Absorption, Distribution, metabolism and excretion of [14C] Levocetrizine, the R enantiomer of cetrizine, in healthy volunteers. European J:of Clinical Pharmacology. 2001;57:571-82.

4.

Panda

S,

Sharma

A,

Simultaneous

spectrophotometric

estimation

of

phenylpropanolamine HCl, bromhexine HCl and chlorpheniramine maleate. indian journal of pharmaceutical sciences. 1999;61(2):116-8.

5. Cavazzutti G. developed a method of Simultaneous Determination of Buzepide, Phenylpropanolamine, and Clocinizine in Pharmaceutical Preparations by Ion-Pair

Reversed-Phase HPLC. Journal of Liquid Chromatography & Related Technologies. 1995 18(2):227 - 34

6. Gagliardi L, Cavazzutti G, de Orsi D, Rotunno T, Tonelli D. HPLC Determination of Dept. of Pharmaceutical analysis | PESCP 41

Review of Literature

Aminopropiophenone as an Impurity in Phenylpropanolamine Bulk Drug and Pharmaceutical Formulations Analytical Letters. 1993; 26(5):937 - 45.

7.

Henry J. Abstracts of the European Association of Poisons Centres and Clinical

Toxicologists XXV International Congress Clinical Toxicology. 2005; 43(5):387 - 538

8. Kenichiro Nakashima. SK, Amal Kaddoumi. Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC 2000;24(7):25-31.

9. Vasudevan M, Ravisankar S, Sathiyanarayanan A, Chandan R. Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC Journal of Pharmaceutical and Biomedical Analysis. 2000. ;24:25-31(7).

10. Yun H, Young J. The Detection Method of Phenylpropanolamine in Pharmaceuticals by High Performance Liquid Chromatography(HPLC). 2001.

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