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Generic Name : Quinidine

Therapeutic Classification : Antiarrhythmics


ICD Code : Y52.2 Trade Name(s):

INDIA- Natcardine, Quinidine. INTERNATIONAL- Quinaglute, Duraquin, Quinact, Quinidex, Cin-Quin, Quinora.

Quinidine is indicated for atrial fibrillation and flutter,

and life-threatening ventricular arrhythmia. Optimal serum concentrations are in the range of 2.0 to 5.0 mcg/mL, with toxicity apparent at levels > or =6.0 mcg/mL.

The half life of quinidine is 6 to 8 hours, and the drug

lacks any significant active metabolites. Physiologic processes that generally reduce hepatic metabolism and renal clearance increase serum quinidine levels while co-medication with cytochrome p450 (CYP) enzyme inducers enhances clearance and results in lower blood concentrations.

Treating and preventing certain abnormal heart

rhythms. Quinidine sulfate is an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm (Antiarrhythmic effect).

Myasthenia Gravis

Complete Heart Block


Partial Heart Block Prolonged Q-T Interval on EKG Chronic Heart Failure Abnormally Low Blood Pressure Emphysema, Liver Problems Kidney Disease, Psoriasis

Poisoning by the Drug Quinidine


Poisoning by the Heart Medication Digitalis

Heart Rhythm Problems from Digitalis or Digoxin

Condition of Increased Mast Cells


Problems with Food Passing Through the Esophagus Anemia from Pyruvate Kinase and G6PD Deficiencies Low Amount of Magnesium in the Blood Low Amount of Potassium in the Blood Delay in Activation of the Left Ventricle of the Heart Defect in Heart's Electrical Intra-ventricular

Conduction Decreased Blood Platelets

QUINIDINE TOXICITY
The toxic reaction of the body to the substance, possibly via allergic reaction or overdose.

ECG changes

Heart block
Asystole Ventricular tachycardia

Ventricular fibrillation
Syncope Seizures

Coma
Death

Symptoms of toxicity (cinchonism) include :

Tinnitus
light-headedness premature ventricular contractions

Atrio-ventricular block.
Gastrointestinal distress is a frequent side effect,

which becomes more severe and is associated with nausea and vomiting at higher drug concentrations.

Verapamil and Quinidine interaction

Alti-Verapamil and Quinidine interaction


Calan and Quinidine interaction Calan SR and Quinidine interaction

Chronovera and Quinidine interaction

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