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INDIA- Natcardine, Quinidine. INTERNATIONAL- Quinaglute, Duraquin, Quinact, Quinidex, Cin-Quin, Quinora.
and life-threatening ventricular arrhythmia. Optimal serum concentrations are in the range of 2.0 to 5.0 mcg/mL, with toxicity apparent at levels > or =6.0 mcg/mL.
lacks any significant active metabolites. Physiologic processes that generally reduce hepatic metabolism and renal clearance increase serum quinidine levels while co-medication with cytochrome p450 (CYP) enzyme inducers enhances clearance and results in lower blood concentrations.
rhythms. Quinidine sulfate is an antiarrhythmic. It works by stabilizing the heart rhythm in conditions in which the heart is beating too fast or in an irregular rhythm (Antiarrhythmic effect).
Myasthenia Gravis
QUINIDINE TOXICITY
The toxic reaction of the body to the substance, possibly via allergic reaction or overdose.
ECG changes
Heart block
Asystole Ventricular tachycardia
Ventricular fibrillation
Syncope Seizures
Coma
Death
Tinnitus
light-headedness premature ventricular contractions
Atrio-ventricular block.
Gastrointestinal distress is a frequent side effect,
which becomes more severe and is associated with nausea and vomiting at higher drug concentrations.