CTC Analyticals AG

Support Training
Page 1
Introductions
Name?
Where are you from?
How long with Agilent/Channel Partner?
Are you Service Engineer or other job?
Chemistry or Electronics background?
Experience with
GC, GC-MS, LC-LC-MS or CTC?
How is your English?

1 - CTC-Agilent Overview
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CTC Analyticals AG
Support Training
for
GC, GC-MS
LC, LC-MS
using
Multi Technique Chemstation
MS Chemstation
EZ Chrom
OpenLab CDS Chemstation Edition
OpenLab CDS EZChrom Edition
Mass Hunter
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1 - CTC-Agilent Overview
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Where design meets performance...

1 - CTC-Agilent Overview
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CTC Sample Injection Technology
Founded 1987 in Basel Switzerland
Started with GC OEM Autosamplers Model A200S
Pittcon 1996 Launch of PAL Systems
Private owned ISO 9001 registered company
Dedicated to gas- and liquid handling systems
Inhouse R&D and QC / Outsourced production
No direct sales and marketing organisation
All systems tested in house prior to shipment
1 - CTC-Agilent Overview
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Why CTC Autosamplers?
1 - CTC-Agilent Overview
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Multipurpose Injection System
Liquid mode with large volume injection up to 500l
Headspace without sample loop or heated transfer line
SPME extraction for heated and agitated samples
ITEX (In Tube Extraction) sample enrichment mode
SPME Headspace
Liquid
NEW
1 - CTC-Agilent Overview
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Sample Capacity
Sample capacity up to:

600 1ml vials
294 2ml vials
96 10ml vials
96 20ml vials
8 96 well microplates
8 384 well microplates
8 96 deepwell plates
1 - CTC-Agilent Overview
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Sample Cooling Options







Tray Cooler
4C 70C
(Peltier version)

Tray Cooler 2
4C 70C
(Peltier version)
200 1ml vials
98 2ml vials

200 1ml vials
98 2ml vials
32 10ml vials
32 20ml vials
1 - CTC-Agilent Overview
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Multi Purpose GC Injectors/Samplers
for
Gas Chromatography
PAL Gas Chromatography Applications
1 - CTC-Agilent Overview
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GC-PAL and Combi-PAL Overview
Mounting Hardware for
6850/6890/7890
Upgrade Options for up to 4 different
Sample Prep Injection Modes
Mounting Hardware for
6850/6890/7890
Liquid Injections only, no upgrade

LHS2
Injector 80
Sampler 120
Sampler 80
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Non Upgradable Configuration

Liquid mode standard configuration
10l syringe kit for liquid injection
1 Tray for 98 2ml vials / 78 1ml vials
1 WashStation for two different solvents and 1 standard liquid
Injector 80
G6502-CTC GC PAL, CTC Colors
G6502B GC PAL, Agilent Injector 80, Agilent branded


1 - CTC-Agilent Overview
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Upgradable Configurations
Sampler 120
Sampler 80

Liquid mode standard configuration (shipped with all Systems)
10l syringe kit for liquid injection
1 Tray for 98 2ml vials / 78 1ml vials
1 WashStation for two different solvents and 1 standard liquid
Headspace mode standard configuration (Option 111, or G6503B)
2.5 ml syringe kit with heated syringe holder
1 Tray for 32 10 or 20ml vials
6 Position Heated Agitator

G6500-CTC Combi-PAL w/ Headspace, CTC Colors
G6501-CTC Combi-PAL w/o Headspace, CTC Colors
G6501B Combi-PAL w/o Headspace, Agilent Sampler 80, Agilent branded

G6509-CTC Combi-PAL 120 cm rail w/o Headspace, CTC Colors
G6509B Combi-PAL 120 cm rail w/o HS, Agilent Sampler 120, Agilent branded
1 - CTC-Agilent Overview
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Model G6501B/G6509B Upgrade Path
Liquid Syringe
Headspace ITEX
SPME
Liquid
1. Starting with Liquid Injection
(G6501B or G6509B)
2. Add Headspace Option (G6503B)
3. Add SPME (G6504B)
HS Option ITEX Traps SPME Option
4. Add ITEX II (soon)
Review: Three Basic GC Systems
Liquid Injections Only, Non Upgradable, 80 cm X Rail
GC-Pal, G6502-CTC,
G6502B Agilent GC Injector 80


Liquid Injections, Supports Headspace, SPME & ITEX II, 80
cm Rail
Combi-Pal, LHS0, LHS2, G6500-CTC, G6501-CTC,
G6501B Agilent GC Sampler 80


Liquid Injections, Supports Headspace, SPME & ITEX II, 120
cm Rail
LHSX, LHS9, G6509-CTC,
G6509B Agilent GC Sampler 120



1 - CTC-Agilent Overview
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1 - CTC-Agilent Overview
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PAL Liquid Chromatography Applications
Liquid Chromatography


High Throughput LC Injectors
1 - CTC-Agilent Overview
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PAL Liquid Chromatography Systems
1 - CTC-Agilent Overview
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Entry Level System LC PAL
Fixed configuration
no options available
Sample Capacity
216 2ml vials
4 x 96/384 Deepwell plates
4 x 96/384 Shallow well plates

Injection Valve
Single 2 position 6-port valve
Bench Space
50 cm width
1 - CTC-Agilent Overview
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Mid range System HTC PAL
Flexible Configuration

Max. Sample Capacity
648 2ml vials
12 96/384 Deepwell plates
24 96/384 Shallow well plates

Cooled Sample Storage Option

Max. Injection Valves
One 2 position 6-port valve
Optional 2 and 3 Valve Operation
Multiposition Valve Drives
Bench Space
50 cm width
High Throughput Compact
1 - CTC-Agilent Overview
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High Throughput System HTS PAL
Flexible Configuration
Max. Sample Capacity
972 2ml vials
18 96/384 Deepwell plates
24 96/384 Shallow well plates

Cooled Sample Storage Option
Max. Injection Valves
Two 2 position 6-port valves
Optional 2 and 3 Valve Operation
Multiposition Valve Drives
PAL Dilutor Option
Bench Space
80 cm width
High Throughput Standard
1 - CTC-Agilent Overview
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IFC PAL FractionCollector
Prep Version
Injection Side
98 2ml vials or 32 10/20ml vials
Collection Side
Tube sizes
1092pcs. 13x100mm (9ml)
700pcs. 16x100mm (12ml)
700pcs. 16x150mm (20ml)
504pcs. 18x150mm (27ml)
504pcs. 20x150mm (34ml)
294pcs. 25x150mm (55ml)
optional Gilson 215 rack holder
Injection / Wash
6-port VICI Valco prep valve
up to 50ml/min
2 different wash solvents
Injection volume up to 5000l
1 - CTC-Agilent Overview
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HPLC PALs Injection volumes
Syringes / CTC label

9 different Sizes
Size Injection range
10l 1 - 10l
25l 2.5 - 25l
50l 5 - 50l
100l 10 - 10l
250l 25 - 250l
500l 50 - 500l
1000l 100 - 1000l
2500l 250 - 2500l
5000l 500 - 5000l
1 - CTC-Agilent Overview
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Sample Storage for HTS / HTC PAL


Trayholders
Stack 4C 40C
(Peltier Cooling)
Microplate Stack
Deepwell Stack
Trays 1/2/10/20ml
Tray 4C 70C
(Peltier Cooling)
1 - CTC-Agilent Overview
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Agilent Products and Instrument Description
1290 Infinity LC Injector HTC
(G4278A)
1290 Infinity LC Injector HTS
(G4277A)
50 cm wide
Up to 12 well plates cooled
40 ppm or 0.004% typical
carryover
Injection volume up to 100 L
with DLW, and up to 5 mL*
with Fast wash
80 cm wide
Up to 24 well plates cooled
40 ppm or 0.004% typical
carryover
Injection volume up to 100 L
with DLW, and up to 5 mL*
with Fast wash
Review: LC Systems and Configurations
HTC/HTS PAL High Throughput LC Injection Systems (2006-
2010)
600 bar Injection valve, fast/active wash station, Generic Pal design
HTC, G4270-CTC: 50cm, compact system, medium capacity
HTS, G4271-CTC: 80cm, standard system, high capacity


1290 Infinity LC Injector HTS/HTC (since 2010)
Proprietary 1200 bar Injection valve, Dynamic Load and Wash DLW, xt-
electronics,
faster cycles times, lower carryover, Agilent Design
HTS, G4277A: 80cm, standard system, high capacity
HTC, G4278A: 50cm, compact system, medium capacity
1 - CTC-Agilent Overview
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1 - CTC-Agilent Overview
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GC PAL / Combi-PAL / HTS / HTC / LC PAL
Local control
Control by handheld terminal without PC
(standalone contact closure remote start operation)

Instrument access for

Local setup and teach function
Method parameters
Sample List
Utility Functions

1 - CTC-Agilent Overview
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Options
1 - CTC-Agilent Overview
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PAL Dilutor Option for HTS PAL
External Dilutor module

Feeds liquid directly through the
injection syringe into samples
Not compatible with DLW
1 - CTC-Agilent Overview
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PAL Barcode Reader
(with B.01.0x only)
Laser scanner reads barcode
labels on 2, 10 and 20ml vials

Transfers data into Sample List

Requires steel caps for magnetic
vial transport

Barcode types
UPC versions A and E
EAN 8 and EAN 13
Code 39
Interleaved 2 of 5
Discrete 2 of 5
Code 128
Code 93
Codabar
1 - CTC-Agilent Overview
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PAL Option Flow Through Cell
Online Analysis Application

Stainless steel flow cell body

Internal Volume 1ml

Flow rate up to 100ml/min

inch Swagelok connectors

Sample aspiration through Teflon
coated Septum

Cleaning port for easy maintenance