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(Sleeping Sickness)
ANDREA BRADY
BIOL 062
Epidemics have
killed hundreds of
thousands since
1900.
http://www.microbiologybytes.com/introduction/Trypa
no.html
http://www.doctorswithoutborders.org/images/news/sleeping/344
76.jpg
www.dcp2.org/pubs/DCP/23/Section/3154
As many as 500,000
Most cases
are found in
Sub-Saharan
Africa.
http://www.dcp2.org/pubs/DCP/23/Table/23.1
Disease Transfer
http://en.wikipedia.org/wiki/Sleeping_sickness
http://farm3.static.flickr.com/2110/1760532740_20189a8cdc.jpg
Disease Transfer
called Trypanosomes
http://www.who.int/mediacentre/factsheets/fs259/en/
http://farm3.static.flickr.com/2110/1760532740_20189a8cdc.jpg
Trypanosomes
are protozoans.
http://www.who.int/mediacentre/factsheets/fs259/en/
http://jcs.biologists.org/content/vol115/issue12/images/medium/jo
ces11512cvf.gif
Trypanosomes
are protozoans.
(unicellular eukaryotes)
(single flagellum)
http://www.who.int/mediacentre/factsheets/fs259/en/
http://jcs.biologists.org/content/vol115/issue12/images/medium/jo
ces11512cvf.gif
http://www.modares.ac.ir/elearning/Dalimi/P
roto/images/Lectures/fig77_1.JPG
Disease Transfer
mainly transferred by
the tsetse fly, which is
found primarily in SubSaharan Africa.
http://www.microbiologybytes.com/introduction/Trypano.html
http://library.truman.edu/test/carol/Tsetse_fly.gif
Areas
Infested
by the
Tsetse Fly
http://www.fao.org/ag/icons/map.gif
Distribution
Map for
African
Sleeping
Sickness
http://www.medicalecology.org/diseases/af
rican_trypano/clip_image002.jpg
Trypanosoma brucei:
Two different parasites
http://www.microbiologybytes.com/introduction/Trypano.html
Trypanosoma brucei:
Two different parasites
http://www.microbiologybytes.com/introduction/Trypano.html
Trypanosoma brucei:
Two different parasites
Trypanosoma brucei
gambiense
Accounts for 90% of
http://www.microbiologybytes.com/introduction/Tr
ypano.html
http://www.dmacc.cc.ia.us/instructors/Image11.gif
Trypanosoma brucei:
Two different parasites
Trypanosoma brucei
rhodesiense
Accounts for 10% of
http://www.microbiologybytes.com/introduction/Tr
ypano.html
http://www.uoguelph.ca/~pwoo/fig6.jpg
Method of Infection
http://www.who.int/mediacentre/factsheets/fs259/en/
http://www.mimg.ucla.edu/faculty/Hill/fig2.jpg
Method of Infection
http://www.who.int/mediacentre/factsheets/fs259/en/
http://io.uwinnipeg.ca/~simmons/16cm05/1116/28-11-TrypanosomaLM.jpg
Method of Infection
http://www.who.int/mediacentre/factsheets/fs259/en/
http://io.uwinnipeg.ca/~simmons/16cm05/1116/28-11-TrypanosomaLM.jpg
Method of Infection
http://www.who.int/mediacentre/factsheets/fs259/en/
http://io.uwinnipeg.ca/~simmons/16cm05/1116/28-11-TrypanosomaLM.jpg
Asymptomatic Phase
http://www.who.int/mediacentre/factsheets/fs259/en/
Asymptomatic Phase
First Stage
(haemolymphatic phase)
http://www.who.int/mediacentre/factsheets/fs259/en/
Asymptomatic Phase
First Stage
(haemolymphatic phase)
Second Stage (neurological phase)
http://www.who.int/mediacentre/factsheets/fs259/en/
First Stage
The pathogens
will spread
throughout the
blood and the
lymph.
http://www.who.int/mediacentre/factsheets/fs259/en/
http://www.pnas.org/content/100/3/F1.medium.gif
First Stage
Symptoms
Fever
Headache
Sweating
Joint Pain
Itching
Swollen Lymph Nodes
www.who.int/mediacentre/factsheets/fs259/en
http://upload.wikimedia.org/wikipedia/commons/thumb/8/88/Wi
nterbottom%27s_sign.jpg/200px-Winterbottom%27s_sign.jpg
Second Stage
Eventually, the disease will manage to cross
Second Stage
Eventually, the disease will manage to cross
Nervous System
www.who.int/mediacentre/factsheets/fs259/en
Second Stage
Symptoms
Confusion
Sensory Disturbances
Poor Coordination
Disturbances of Sleep
Cycles
www.who.int/mediacentre/factsheets/fs259/en
http://www.msf.org.uk/UploadedImages/e64ac496-41d9-4b8b8cac-423baecb957f.jpg
disease is fatal.
www.who.int/mediacentre/factsheets/fs259/en
Treatment varies
depending on the
stage of the
disease.
www.who.int/mediacentre/factsheets/fs259/en
http://www.sawitfirst.co.uk/media/pill_clockbig.gif
http://www.who.int/mediacentre/factsheets/fs259/en/
http://www.who.int/mediacentre/factsheets/fs259/en/
available for
treatment
http://www.pet-comfort-products.com/images/colorful-pills01.gif
available for
treatment
Two available for firststage treatment
Two available for
second-stage treatment
www.who.int/mediacentre/factsheets/fs259/en
www.pet-comfort-products.com/images/colorful-pills-01.gif
http://www.who.int/mediacentre/factsheets/fs259/en/
the first-stage is
So, in summary,
treatment during
the first-stage
is
More
effective
http://images.thescientist.com/content/figures/images/yr2002/may13/iv.jpg
So, in summary,
treatment during
the first-stage
is
More
effective
Safer
http://images.thescientist.com/content/figures/images/yr2002/may13/iv.jpg
Therefore,
early diagnosis
is imperative
http://www.who.int/mediacentre/factsheets/fs259/en/
http://www.bayerscheringpharma.de/html/images/upload/gesells
chaftliches_engagement/aerztin_patient_205.jpg
http://www.ecdl.com/countries/images/map_africa.gif
Organizations like
http://www.who.int/mediacentre/factsheets/fs259/en/
http://www.who.int/mediacentre/factsheets/fs259/en/
Organizations like
http://www.who.int/mediacentre/factsheets/fs259/en/
http://www.who.int/mediacentre/factsheets/fs259/en/
http://www.kfwh.org/information.asp
THE END.