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Metabolism
Metabolism
Anabolism
Performance of structural
maintenance and repairs
Support of growth
Production of secretions
Building of nutrient reserves
Catabolism
Breakdown of nutrients to
provide energy (in the form of
ATP) for body processes
Carbohydrate Metabolism
Primarily glucose
Blood Glucose
Homeostasis
Fates of Glucose
Fed state
Storage as glycogen
Storage as lipids
Liver
Skeletal muscle
Adipose tissue
Fasted state
Synthesis
Synthesis and
and
breakdown
breakdown occur
occur
at
at all
all times
times
regardless
regardless of
of
state...
state...
The
The relative
relative rates
rates
of
of synthesis
synthesis and
and
breakdown
breakdown
High Blood
Glucose
Pancreas
Muscle
Glucose
absorbed
Insulin:
Glucago
n
Adipose
Cells
Glucose
absorbed
Glycogen
Glucose
absorbed
Glucose Metabolism
Glucose
Utilization
Adipose
Energy
Stores
Glycogen
Glucose
Pentose
Phosphate
Pathway
Ribose-5-phosphate
Glycolysis
Pyruvate
Glucose
Utilization
Adipose
Energy
Stores
Glycogen
Glucose
Pentose
Phosphate
Pathway
Ribose-5-phosphate
Glycolysis
Pyruvate
Glycolysis
Glucose Pyruvate
Acetyl-CoA (TCA cycle)
Glycolysi
s
Glucose + 2 ADP + 2 Pi
2 Lactate + 2 ATP + 2 H2O
rechargeable battery
ADP + P + Energy
ATP
Substrate-level phosphorylation
Oxidative phosphorylation
Glycolysis - Summary
2 ATP
Glucos
e
4 ADP
2
ADP
4 ATP
2
NAD
2 NADH + H
2 Pyruvate
Pyruvate Metabolism
Pyruvate Metabolism
Anaerobic
Metabolism of
Pyruvate
Problem:
Anaerobic
Metabolism of
Solution:
Pyruvate
NAD+
COO
C
CH3
Pyruvate
(oxidized)
COO
Lactatedehydrogenase
HC
OH
CH3
Lactate
(reduced)
Anaerobic
Metabolism of
Pyruvate
ATP
yield
Pyruvate
Lactate
NADH
NAD+
Cori Cycle
Lactate is
converted to
pyruvate in the liver
Pyruvate Metabolism
Pyruvate metabolism
Ketoglutarate
COO
C
CH 3
Pyruvate
Keto acid
COO
Alanineaminotransferase
(AAT)
HC
NH 3+
CH 3
Alanine
Amino acid
Pyruvate Metabolism
Pyruvate Dehydrogenase
Complex (PDH)
Aerobic Conditions
Electron
Transpor
t Chain
TCA
Cycle
PDH - Summary
Pyruvat
e
2
NAD
2 NADH + H
CO2
Acetyl
CoA
TCA Cycle
1 ATP
3
NAD
1
ADP
3 NADH +
H
1 FAD
1 FADH2
Oxidative
Phosphorylation
Oxidative Phosphorylation
and the Electron Transport
System
Feed donates H+
H+s transferred to co-substrate
NADH + H+
FADH2
3.
NADH + H+
FADH2
3 ATP
2 ATP
Acetate
Propionate
Butyrate
Acetic acid
Propionic acid
Yields 10 ATP
Yields 18 ATP
Butyric acid
Yields 27 ATP
Little butyrate enters blood
Utilization of VFA in
Metabolism
Acetate
Energy
Carbon source for fatty acids
Adipose
Mammary gland
Propionate
Energy
Precursor of glucose
Butyrate
Energy
Carbon source for fatty acids - mammary
Feed donates H+
H+s transferred to co-substrate
NADH + H+
FADH2
Oxidative
Phosphorylation
A BRIEF INTERLUDE
Working animals
Hummingbirds
Substrate-level phosphorylation
Glucose
Pyruvate
Lactate
Creatine + ATP
Anaerobic glycolysis
Phosphocreatine + ADP
Glucose
Pyruvate
Fatty Acid
Acetate
Pyruvate
Anaerobic glycolysis
Glucose
Glucose
Pyruvate
Lactate
Substrate-level phosphorylation
Phosphocreatine + ADP
Creatine + ATP
Glucose
Utilization
Adipose
Energy
Stores
Glycogen
Glucose
Pentose
Phosphate
Pathway
Ribose-5-phosphate
Glycolysis
Pyruvate
Produces NADPH
Similar to NADH
Required for fatty acid synthesis
Ribose
Used for synthesis of nucleic acids
6Phosphogluconolactone
6Phosphogluconate
D-Ribulose5phosphate
RNA or
DNA
D-Ribose5phosphate
Glucose
Utilization
Adipose
Energy
Stores
Glycogen
Glucose
Pentose
Phosphate
Pathway
Ribose-5-phosphate
Glycolysis
Pyruvate
Energy Storage
Glucose
Utilization
Adipose
Energy
Stores
Glycogen
Glycogenesi
s
Glucose
Pentose
Phosphate
Pathway
Ribose-5-phosphate
Glycolysis
Pyruvate
Glycogenes
is
Liver
Glycogenesis
Skeletal muscle
1% of wet weight
Fates of Glucose
Fed state
Storage as glycogen
Storage as lipids
Liver
Skeletal muscle
Adipose tissue
Fasted state
Synthesis
Synthesis and
and
breakdown
breakdown occur
occur
at
at all
all times
times
regardless
regardless of
of
state...
state...
The
The relative
relative rates
rates
of
of synthesis
synthesis and
and
breakdown
breakdown
Gluconeogenesis
Necessary process
Gluconeogenesis
Feline species
Proteolysis
Low Blood
Glucose
Pancreas
Muscle
Proteins Broken
Down
Insulin:
Glucago
n
Glycogen
Glucose released
Adipose
Cells
Glycerol, fatty acids
released
Gluconeogenesis
Amino acids
Lactate
Supply carbon skeleton
Pyruvate
Propionate
There is no glucose synthesis from fatty acids
Carbohydrate Comparison
Carbohydrate Comparison
Importance of gluconeogenesis
MOST monogastrics = less important
Ruminant = very important
Ketone production
MOST monogastrics = abnormal
situation