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Susila Sastri
Metabolisme Lemak
The Differences
Transportation of Digested
Fat
Re-formed into triglycerides
Packaged into chylomicrons
Lipoprotein lipase breaks down
triglycerides in the chylomicrons
Fatty acids are absorbed by cells
Takes 2-10 hours to clear
chylomicron
Lipoproteins
Transport of Synthesized
Fats
Liver produces some fat and cholesterol from
carbohydrate, protein, and free fatty acids taken
up from the blood
Liver packages cholesterol and triglycerides for
transport as Very Low Density Lipoprotein
(VLDL)
Remnants of chylomicrons, small and medium FA,
and cholesterol get put together to form a VLDL
(very low density lipoprotein)
Lipoprotein
class
Density
(g/mL)
Diameter
(nm)
Protein % Phosphol
of dry wt ipid %
Triacylglycerol
% of dry wt
HDL
1.063-1.21
5 15
33
29
LDL
1.019
1.063
18 28
25
21
IDL
1.006-1.019
25 - 50
18
22
31
VLDL
0.95 1.006
30 - 80
10
18
50
chylomicrons
< 0.95
100 - 500
1-2
84
most proteins have densities of about 1.3 1.4 g/mL and lipid aggregates usu
have densities of about 0.8 g/mL
Apoproteins of human
lipoproteins
A-1 (28,300)- principal protein in HDL
90 120 mg% in plasma
Apoproteins of human
lipoproteins
C-1 (7,000) found in chylomicron, VLDL, HDL
4 7 mg %
Lipoprotein Interactions
15
Pathway of -Oxidation
FATTY ACID
SYNTHESIS
Metabolism of adipose
tissue
Metabolic ischemia. Glycolysis is the main catabolic pathway during ischemia, whereas fatty acid
oxidation is enhanced in this period. As consequence less ATP is generated at the expenses of more
protons production, which are ultimately responsible for myocardial acidosis and ions (mainly Calcium)
accumulation (see text for more details).
Redarrows : enhanced pathway; white arrows : almost abolished pathways