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D R A N I L C H A U D H A RY
A S S O C I AT E P R O F E S S O R
PHYSIOLOGY
LIVER
Location
R. Hypochondrium
Epigastric region
4 Lobes
Left
Quadrate
Caudate
Right
LIVER
The Liver
has tremendous
variety of
functions,
including the
secretion of
bile for
digestive
purposes.
-Largest Gland of
Body
STRUCTURE OF LIVER
Liver largest internal organ.
Hepatocytes form hepatic plates that are 12 cells thick.
Arranged into functional units called lobules.each with
diameter of 0.5 to 2 mm.
MICROSCOPIC ANATOMY
bile ductule
STRUCTURE OF LIVER
(CONTINUED)
LIVER HISTOLOGY
Figure 2420
LIVER
Dual blood
supply
Hepatic portal vein
Direct input from small
intestine
Hepatic artery/vein
Direct links to heart
12
15
HEPATOCYTES
In a liver lobule form a series of
irregular plates arranged like wheel
spokes
Blood enters liver sinusoids:
from small branches of hepatic portal vein
from hepatic artery proper
hepatic duct
cystic
duct
common hepatic duct
common bile duct
gallbladder
hepatopancreatic
sphincter
pancreas
duodenum
FUNCTIONS OF THE
LIVER
LIVER
Detoxifies/removes
Drugs
Alcohol
Stores
Gycolgen
Vitamins (A, D, E, K)
Fe and other minerals
Cholesterol
Activates vitamin D
Fetal RBC production
Phagocytosis
Metabolizes absorbed food
molecules
Carbohydrates
Proteins
Lipids
24
DETOXIFICATION OF THE
BLOOD
Liver can remove hormones, drugs,
and other biologically active
molecules from the blood by:
Excretion into the bile.
Phagocytosis by Kupffer cells.
Chemical alteration of the molecules.
Ammonia is produced by deamination of amino acids in
the liver.
Liver converts it into urea.
Excreted in urine.
DETOXIFICATION OF THE
BLOOD
(CONTINUED)
PRODUCTION OF PLASMA
PROTEINS
Albumin and most of the plasma
globulins (except gama globulins)
are produced by the liver.
Albumin:
Constitutes 70% of the total plasma protein.
Contributes most to the colloidal osmotic pressure in the
blood.
Globulins:
Transport cholesterol and hormones.
Produce blood clotting factors I, II, III, V, VII, IX,
XI.
LIVER FUNCTIONS
CLINICAL APPLICATION
Hepatitis