Chapter 11

Regression and Correlation

methods

EPI 809/Spring 2008

Learning Objectives
1.

Describe the Linear Regression Model

2.

State the Regression Modeling Steps

3.

Explain Ordinary Least Squares

4.

Compute Regression Coefficients

5.

Understand and check model assumptions

6.

Predict Response Variable

7.

Comments of SAS Output

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Learning Objectives
8.

Correlation Models

9.

Link between a correlation model and a

regression model

10.

Test of coefficient of Correlation

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Models

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What is a Model?

1.

Representation of
Some Phenomenon
Non-Math/Stats Model

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What is a Math/Stats Model?

1.

Often Describe Relationship between

Variables

2.

Types
-

Deterministic Models (no randomness)

Probabilistic Models (with randomness)

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Deterministic Models
1.
2.
3.

Hypothesize Exact Relationships

Suitable When Prediction Error is Negligible
Example: Body mass index (BMI) is measure of
body fat based

Metric Formula: BMI = Weight in Kilograms

(Height in Meters) 2
Non-metric Formula: BMI = Weight (pounds)x703
(Height in inches)2
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Probabilistic Models
1.

2.

Hypothesize 2 Components
Deterministic
Random Error
Example: Systolic blood pressure of newborns
Is 6 Times the Age in days + Random Error
SBP = 6xage(d) +
Random Error May Be Due to Factors
Other Than age in days (e.g. Birthweight)

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Types of
Probabilistic Models
PP r roo bb aa bb i il li iss t ti icc
MM oo dd ee l lss

RR ee gg r ree ss ss i ioo nn
MM oo dd ee l lss

CC oo r rr ree l laa t ti ioo nn

MM oo dd ee l lss

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OO t thh ee r r
MM oo dd ee l lss

Regression Models

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Types of
Probabilistic Models
PP r roo bb aa bb i il li iss t ti icc
MM oo dd ee l lss

RR ee gg r ree ss ss i ioo nn
MM oo dd ee l lss

CC oo r rr ree l laa t ti ioo nn

MM oo dd ee l lss

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OO t thh ee r r
MM oo dd ee l lss

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Regression Models
Relationship between one

dependent
variable and explanatory variable(s)
Use equation to set up relationship
Numerical Dependent (Response) Variable
1 or More Numerical or Categorical Independent
(Explanatory) Variables

Used Mainly for Prediction & Estimation

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Regression Modeling Steps

1.

Hypothesize Deterministic Component

Estimate Unknown Parameters

2.

Specify Probability Distribution of

Random Error Term
Estimate Standard Deviation of Error

3.

Evaluate the fitted Model

4.

Use Model for Prediction & Estimation

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Model Specification

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Specifying the deterministic

component
1.

Define the dependent variable and

independent variable

2.

Hypothesize Nature of Relationship

Expected Effects (i.e., Coefficients Signs)
Functional Form (Linear or Non-Linear)
Interactions
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Model Specification
Is Based on Theory
1.
2.
3.
4.

Theory of Field (e.g., Epidemiology)

Mathematical Theory
Previous Research
Common Sense

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Thinking Challenge:
Which Is More Logical?
CD+ counts

Years since seroconversion

CD+ counts

Years since seroconversion

CD+ counts

Years since seroconversion

CD+ counts

Years since seroconversion

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OB/GYN Study

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Types of
Regression Models

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Types of
Regression Models
Regression
Models

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Types of
Regression Models
1 Explanatory
Variable

Regression
Models

Simple

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Types of
Regression Models
1 Explanatory
Variable

Regression
Models

2+ Explanatory
Variables

Multiple

Simple

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Types of
Regression Models
1 Explanatory
Variable

Regression
Models

2+ Explanatory
Variables

Multiple

Simple

Linear

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Types of
Regression Models
1 Explanatory
Variable

Regression
Models

Multiple

Simple

Linear

2+ Explanatory
Variables

NonLinear

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Types of
Regression Models
1 Explanatory
Variable

Regression
Models

2+ Explanatory
Variables

Multiple

Simple

Linear

NonLinear

Linear

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Types of
Regression Models
1 Explanatory
Variable

Regression
Models

2+ Explanatory
Variables

Multiple

Simple

Linear

NonLinear

Linear

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NonLinear

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Linear Regression
Model

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Types of
Regression Models
1 E x p la n a to ry
V a ria b le

R e g re s s io n
M o d e ls

2 + E x p la n a to ry
V a ria b le s

M u ltip le

S im p le

L in e a r

NonL in e a r

L in e a r

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NonL in e a r

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Linear Equations
Y
Y = m X + b
m = S lo p e

Change
in Y

C h a n g e in X
b = Y -in te r c e p t

1984-1994 T/Maker Co.

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Linear Regression Model

1.

Relationship Between Variables Is a

Linear Function
Population
Y-Intercept

Population
Slope

Random
Error

Yi 0 1X i i
Dependent
(Response)
Variable
(e.g., CD+ c.)

Independent
(Explanatory) Variable
(e.g., Years s. serocon.)

Population & Sample

Regression Models

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Population & Sample

Regression Models
Population

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Population & Sample

Regression Models
Population
Unknown
Relationship

Yi 0 1X i i

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Population & Sample

Regression Models
Random Sample

Population
Unknown
Relationship

Yi 0 1X i i

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Population & Sample

Regression Models
Random Sample

Population
Unknown
Relationship

Yi 0 1X i i

Yi 0 1X i i

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Population Linear Regression

Model
Y

Yi 0 1X i i

Observed
value

i = Random error
E Y 0 1 X i

X
Observed value
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Sample Linear Regression

Model
Y

Yi 0 1X i i
^i = Random
error

Yi 0 1X i

Unsampled
observation

X
Observed value
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Estimating Parameters:
Least Squares Method

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Scatter plot
1.

Plot of All (Xi, Yi) Pairs

2. Suggests How Well Model Will Fit
60
40
20
0

20

40

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X
60
39

Thinking Challenge
How would you draw a line through the
points? How do you determine which line
fits best?
60
40
20
0

20

40

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X
60
40

Thinking Challenge
How would you draw a line through the
points? How do you determine which line
fits best?
Slope changed

60
40
20
0

20

40

X
60

Intercept unchanged
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Thinking Challenge
How would you draw a line through the
points? How do you determine which line
fits best?
Slope unchanged

60
40
20
0

20

40

X
60

Intercept changed
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Thinking Challenge
How would you draw a line through the
points? How do you determine which line
fits best?
Slope changed

60
40
20
0

20

40

X
60

Intercept changed
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Least Squares
1.

Best Fit Means Difference Between

Actual Y Values & Predicted Y Values Are
a Minimum. But Positive Differences OffSet Negative ones

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Least Squares
1.

Best Fit Means Difference Between

Actual Y Values & Predicted Y Values is a
Minimum. But Positive Differences Off-Set
Negative ones. So square errors!
n

Y
i i
i 1

2
i

i 1

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Least Squares
1.

Best Fit Means Difference Between

Actual Y Values & Predicted Y Values Are a
Minimum. But Positive Differences Off-Set
Negative. So square errors!

i 1

Yi Yi

2
i

i 1

2.

LS Minimizes the Sum of the Squared

Differences (errors) (SSE)
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Least Squares Graphically

n

2
2
2
2
2

LS minimizes i 1 2 3 4
i 1

Y2 0 1X 2 2
^ 44

^ 22
^ 11

^ 33

Yi 0 1X i
X

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Coefficient Equations

Prediction equation

yi 0 1 xi

Sample slope
SS xy xi x yi y
1

2
SS xx

Sample Y - intercept

0 y 1x
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Derivation of Parameters (1)

Least Squares (L-S):

Minimize squared error
n
n

i yi 0 1 xi
i 1

2
i

i 1

yi 0 1 xi

2 ny n 0 n1 x

0 y 1x
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Derivation of Parameters (1)

Least Squares (L-S):

Minimize squared error
2
i2
yi 0 1 xi
0

2 xi yi 0 1 xi

2 xi yi y 1 x 1 xi
1 xi xi x xi yi y

1 xi x xi x xi x yi y
SS xy

1
SS xx
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Computation Table
Xi

Yi

X1

Y1

X2

Y2

2
Xi
2
X1
2
X2

Yn

2
Xn

2
Yn

XnYn

Yi

2
Xi

2
Yi

XiYi

Xn
Xi

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2
Yi
2
Y1
2
Y2

X1Y1

XiYi
X2Y2

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Interpretation of Coefficients

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Interpretation of Coefficients
1.

Slope (1)

^
Estimated Y Changes by 1 for Each 1 Unit
Increase in X

^
If 1 = 2, then Y Is Expected to Increase by 2 for
Each 1 Unit Increase in X

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Interpretation of Coefficients
^
1. Slope (1)

^
Estimated Y Changes by 1 for Each 1 Unit
Increase in X
^

If 1 = 2, then Y Is Expected to Increase by 2 for

Each 1 Unit Increase in X

^
2. Y-Intercept (0)

Average Value of Y When X = 0

^
If 0 = 4, then Average Y Is Expected to Be
4 When X Is 0
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Parameter Estimation Example

Obstetrics: What is the relationship between

Mothers Estriol level & Birthweight using the

following data?
Estriol
Birthweight
(mg/24h)

(g/1000)

1
2
3
4
5

1
1
2
2
4
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Scatterplot
Birthweight vs. Estriol level
Birthweight

Estriol level
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Parameter Estimation Solution

Table
Xii

Yii

Xii22

Yii22

XiiYii

16

25

16

20

15

10

55

26

37

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Parameter Estimation Solution

11

nn

X ii

nn
ii11

X
Y

ii ii
n
ii11

nn

22

ii
ii11

nn

nn

Y
ii11

ii
ii11

22

ii

1510
37

5
0.70
22

15
55
5

00 Y 11X 2 0.70 3 0.10

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Coefficient Interpretation
Solution

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 1.

Coefficient Interpretation
Solution
^
^

Slope (1)

Birthweight (Y) Is Expected to Increase by .7

Units for Each 1 unit Increase in Estriol ( X)

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 1.

2.

Coefficient Interpretation
Solution
^
^

Slope (1)

Birthweight (Y) Is Expected to Increase by .7

Units for Each 1 unit Increase in Estriol ( X)
^

Intercept (0)

Average Birthweight (Y) Is -.10 Units When

Estriol level (X) Is 0
Difficult to explain
The birthweight should always be positive

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SAS codes for fitting a simple linear

regression

Data BW; /*Reading data in SAS*/

input estriol birthw@@;
cards;
1 1
2
1
3
2
4 2
5
4
;
run;
PROC REG data=BW; /*Fitting linear regression models*/
model birthw=estriol;
run;
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Parameter Estimation
SAS Computer Output
Parameter Estimates

Variable

DF

Intercept
Estriol

^0

1
1

Parameter
Estimate
-0.10000
0.70000

Standard
Error t Value
0.63509
0.19149

-0.16
3.66

Pr > |t|
0.8849
0.0354

^
1
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Parameter Estimation Thinking

Challenge

Youre a Vet epidemiologist for the county

cooperative. You gather the following data:
Food (lb.) Milk yield (lb.)
4
3.0
6
5.5
10
6.5
12
9.0
What is the relationship
between cows food intake and milk yield?

1984-1994 T/Maker Co.

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Scattergram
Milk Yield vs. Food intake*
M. Yield (lb.)

10
8
6
4
2
0

10

15

Food intake (lb.)

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Parameter Estimation Solution

Table*
Xii

Yii

22
Xii

3.0

16

9.00

12

5.5

36

30.25

33

10

6.5

100

42.25

65

12

9.0

144

81.00

108

32

24.0

296 162.50 218

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22
Yii

XiiYii

66

Parameter Estimation Solution*

11

nn

X ii

nn
ii11

X
Y

ii ii
n
ii11

nn

22

ii
ii11

nn

nn

Y
ii11

ii
ii11

22

ii

32 24
218

4
0.65
22

32
296
4

00 Y 11X 6 0.65 8 0.80

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Coefficient Interpretation
Solution*

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Coefficient Interpretation
Solution*
1.

Slope (1)
Milk Yield (Y) Is Expected to Increase by .65
lb. for Each 1 lb. Increase in Food intake ( X)

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Coefficient Interpretation
Solution*
1.

2.

Slope (1)
Milk Yield (Y) Is Expected to Increase by .65
lb. for Each 1 lb. Increase in Food intake (X)

Y-Intercept (0)
^

^
Average Milk yield (Y) Is Expected to Be 0.8
lb. When Food intake (X) Is 0
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