Alza Pharmaceuticals

November 06, 2003

Nina Patel
Jesus Lopez
Truc Le
Brigitte Comrie

Mission Statement
As new compounds emerge from
biotechnology and genetic research,
ALZA technologies continue to
evolve, providing unique delivery
platforms that extend the potential of
important new therapies. Year after
year, we deliver results that benefit
healthcare and expand market
opportunities for our pharmaceutical
partners.

Alza History

Founded in 1968
by Dr. Alejandro
Zaffaroni

Headquarters
located in
Mountain View,
California

Other facilities
throughout the U.S.

Alza History cont.

1973 First
technology was
developed: OROS

1976 ALZA
introduced ALZET
Osmotic
Pumps

Alza History cont.

1999 ALZA
merges with
Sequus
Pharmaceuticals

2001 ALZA
becomes part of
Johnson &
Johnsom family of
companies

Alza Technology

OROS Oral Delivery

D-Trans Transdermal
STEALTH Liposomal
DUROS Implant
E-Trans Transdermal
Macroflux Transdermal
ALZAMER Depot

Other

OROS Oral Delivery

11 Commercial
Products

Sudafed - 24 hour
relief

Concerta reduce
ADHD symptoms

OROS Oral Delivery

Investments:

Improve poor aqueous solubility

Improve poor absorption
Reduce large molecular size of products

OROS Oral Delivery

Control drug delivery for up to 24

hours

Provide efficient drug absorption

and enhanced bioavailability

Eliminate drug absorption

variability caused by gastric pH
and motility

D-Trans Transdermal
7 commercial products

Nicoderm
Nicotine Patch

Transderm Scop
Motion Sickness

D-Trans Transdermal

Investments:
Increase drug permeation through skin
Reduce irritation potential

D-Trans Transdermal

Drug delivery 1 day

to 1 week with one
application

Convenient, painless,
cost-effective

Enhance therapeutic
efficacy while
decreasing side
effects because
avoids effects on the
gastrointestinal tract

STEALTH Liposomal
Doxil

Intravenous anticancer drug

Treats refractory ovarian cancer and
AIDS related Kaposis

STEALTH Liposomal

Designed to reduce toxicity of

intravenous drugs with site
specific targeting

Materials
Liposomes: liquid microspheres
Polyethylene glycol coating

Liposomal Microsphere

STEALTH Liposomal

Not detected by the

immune system

Targets leaky
vasculature of
diseased tissue for
increase drug
concentration

Ligan-recptor binding
system improves
uptake of drug

ALZA Technologies

DUROS Implant: Viadur

Treats Prostate Cancer

E-Trans Transdermal:
Capability of an IV pumps without the needle

Macroflux Transdermal:
Thin titanium screen with precision
microprojections

ALZAMER Depot:
extended period drug delivery

Commercial Products

Actisite (tetracycline)
periodontal fiber
Reduces pocket depth and bleeding on
probing in patients with adult periodontitis

ALZET
osmotic pumps for laboratory research.

Baxter Infusor
controlled intravenous delivery of
anticoagulants, antibiotics and
chemotherapeutic agents

Commercial Products

IVOMEC SR Bolus (ivermectin)

control of major internal and external
parasites in cattle

Ocusert (pilocarpine)
ocular therapeutic systems
Controls elevated intraocular pressure
glaucoma patients

Progestasert (progesterone)
intrauterine contraceptive system for
localized delivery of progesterone for one year

Working for Alza

Member of Johnson and Johnson

Over 2000 employees at three
sites: Mountain View, CA; Vacaville,
CA; Cashel, Ireland
Small company environment, big
company impact
Different opportunities (internships,
graduate positions, etc.)

Work Environment

Small company environment, Big

company impact
Team oriented employees
Dedicated to improving the lives
of people worldwide

Alza Values

Knowledge, skills, and the

abilities of their employees
Dedication to creating and
developing high quality products
Providing several different
opportunities for employees to
exchange ideas and socialize with
colleagues

Benefits

Johnson and Johnson

Perks
Medical Insurance
Dental Insurance
Life Insurance (Term and
Universal)
Accident Insurance
Short Term Disability
coverage
Long Term Disability
coverage
Long Term Care
Pension Plan
Savings Plan (401k)
Adoption Assistance

Additional Alza benefits

Employee Stock Purchase
Plan
Tuition Reimbursement
Vacation
Company Holidays
Company Stores/E-Stores
Exercise Programs
Daycare Discounts
Service Award Program
Lifeworks Program
Charitable Contributions
Matching Gift Program

Questions