You are on page 1of 27

.

Coffea semen, Coffea spp,


Rubiaceae
:
3529/13
3567/13
3546/13

:
. -

,
2015

Cofea spp, Rubiaceae


.
, , ,
, .
,
.
,
.
.
.
C.arabica () C.canephora ().

. ,
. . ,
, - .
, . ,
200-250,
. , ,

.


, , ,
.
,
.
: ,
.
. , .
: , .



- , 1.0-2.5%
- ( )
- 6 ,


- 8-12% .
.
- .
- , .


50%, .
(, , )
. . ,
, .


,
.
; in vitro
.


,
.


,
.

.


. ,
(1/A2).
, ,
.
,
cAMP : ,
.

, , .

. , .
,
,
. ,
.
.


, , , ,
, .
, ,
, . ,
.
, .

.
,
,
. ,
,
.
,
.

The relation between estimated glomerular filtration


rate (eGFR) and coffee consumption in the Japanese

(eGFR)

Nobuyuki Miyatake1*, Kenichi Shikata2,3, Hirofumi Makino3, Takeyuki Numata4


Department of Hygiene, Faculty of Medicine, Kagawa University, Kagawa, Japan; *Corresponding Author
Center for Innovative Medicine, Okayama University Hospital, Okayama, Japan;
3
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry
and Pharmaceutical Sciences, Okayama, Japan;
4
Okayama Southern Institute of Health, Okayama Health Foundation, Okayama, Japan.
Received August 10th, 2011; revised August 26th, 2011; accepted September 5th, 2011.
1

Vol.3, No.9, 549-552 (2011) doi:10.4236/health.2011.39093


eGFR
.
eGFR.
20%
(chronic kidney disease CDK) GFR < 60ml/min/1,73 m2 3
.

2.
. :

1 170 (376 794 )


20-78 .


: 15 ,
: model 7700; HITACHI, Tokyo, Japan
eGFP: eGFR (ml/min/1.73 m2) = 194 Cr1.094 Age0.287 () and eGFR
(ml/min/1.73 m2) = 194 Cr1.094 Age0.287 0.739 ()

- 1 ; - ,
1 <

233 (62.0%) 400 (50.4%) ,


50-ti 70-ti

body mass index (BMI)

3.
.1

. 1 eGFP

. 2

. 3 eGFR

4.
eGFR
.
eGFR.
,
.
1170
, .
eGFR
.
10.6
, 40 59 ( 13.5, 14.2)
Japan Coffee Association.

Stimulatory effect of Whole Coffe Fruit


Concentrate Powder on Plasma Levels of
Total and Exsosomal Brain-Derived
Neurotrophic Factor in Healthy subjects


BRAIN-DERIVED NEUROTROPHIC
FACTOR (BDNF)

Tania Reyes-Izquierdo1*, Ruby Argumedo1, Cynthia Shu1, Boris


Nemzer2, Zb Pietrzkowski1
1Applied BioClinical Inc., Irvine, USA;
2FutureCeuticals Inc., Momence, USA.
Received June 2nd, 2013; revised July 2nd, 2013; accepted July 9th, 2013
Copyright 2013 Tania Reyes-Izquierdo et al.
Food and Nutrition Sciences, 2013, 4, 984-990 , Published Online September

1.

BDNF
.

BDNF,
.

2. BDNF
1.
2.

3. ,
4.
5.

3.
20 25-35
1
2 100ml
3 300ml


12
h, .
100
,
60 120min,
T0, T60
120.

4.
Coffea Arabica


BDNF
,
.

,
.
4.
- exosome binding buffer, .
,
.

-
: p<0.001
1)
:
60 = 5% (p=0.5)
120 = 26% (p=0.02)
2)
:
60 = 91%
120 = 66%
3)
:
60 = 21% (p=0.1)
120 = 15% (p=0.2)

:
60=206%
120=39%


, 60
,
2 .
, ,
.

, .

, (
).



,
, (. ).

You might also like