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Toxicology
Outlines
1.
2.
3.
4.
5.
6.
Introduction Definition
A. Toxicology: study of adverse effects of
toxicants on biological organisms
B. Toxicants: chemical or physical agent
including dusts, fibers, noise and radiation
C. Toxicity: property of the agent describing
its effect on biological organisms
D. Toxic Hazard: likelihood of damage to
biological organisms based on exposure
Routes of Entry
INGESTION
ABSORPTION *
INJECTION
Routes of Entry
INGESTION
Swallowing a
substance
causes
penetration
into the blood
stream via
the stomach
and small
intestine.
INHALATION
INGESTION
ABSORPTION
INJECTION
INHALATION
Breathing and
smoking causes
us to inhale
substances
which enter the
lungs.
Substance
inhaled into the
lungs are
readily
absorbed into
blood
the
stream.
INHALATION
INGESTION
ABSORPTION
Routes of Entry
INJECTION
ABSORPTION
Injection occurs
when
substances are
forced through
this skin. This
can occur as a
result of such
means as
compressed air,
or by having the
skin scratched
bya penetrating
INHALATION
object.
the body
is the
INHALATION
same.
INGESTION
ABSORPTION
INGESTION
ABSORPTION
DANGER
CANCER
CAUSING
AGENT
Increasing Dose
Chapter 3(a): Toxicology
Toxic
Effect
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Figure 2-13 Two toxicants with differing relative toxicities at different doses.
Toxicant A is more
toxic at high doses, whereas toxicant B is more toxic at low doses.
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mg/kg
Normally expressed as
milligrams of substance per
kilogram of animal body
weight
mg/L
Normally expressed as milligrams
of substance per liter of air or
water (or as ppm)
15
u
Y 5
P
exp du
1 2
2
2
16
18
Y = k1 +k2 ln V
Where
V is the causative
variables
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21
22
Y = mslopelog(dose) + intercept
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Figure 2-10 The probit transformation converts the sigmoidal response versus
log dose curve
into a straight line when plotted on a linear probit scale. (Source: D. J.
Finney,
Probit Analysis, 3rd ed. (Cambridge: Cambridge University Press,
1971), p. 24.
Chapter 3(a): Toxicology
Reprinted by permission.)
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22.4 T 1
3
(
mg
/
m
)
M 273 P
M is molecular weight
T is temperature in Kelvin
P is pressure in atm
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