Professional Documents
Culture Documents
HORMONES
Dihydrotestosterone
the skin
produced peripherally
Other metabolites of
testosterone
Sex-Hormone binding
globulin
hyperthyroidism
Decreased by androgens, advancing age,
hypothy
Function:
hormone (GRH)
Testosterone Metabolism
2 pathways:
Oxidation at C-17 position less active
compound
Reduction at C-5 position produces DHT
Functions of
testosterone
FEMALE SEX
HORMONES
SYNTHESIS OF
PROGESTERONE
SYNTHESIS OF
ESTROGEN
BIOSYNTHESIS OF
ESTROGEN
SYNTHESIS OF
ESTROGEN
Biosynthesis of Estrogens
Cholesterol
Pregnenolone
Progesterone
aromatase
Estrone (E1)
16-hydroxylase
Estriol
DHEA
Androstenedione
Testosterone
aromatase
17-Estradiol
(E2)
Aromatase
A mixed-function oxidase
Requires O2 and NADPH
Peripheral aromatization
binds
B. Progesterone
- sodium pregnanediol-2-glucuronide is the
progestin found in urine
- synthetic steroids, e.g. derivatives of 17hydroxyprogesterone avoid hepatic
widely used as contraceptives
major
metabolism;
General functions
Hormones prepare female reproductive system for
reproduction by:
1. Maturing the primordial germ cells
2. Developing the tissues that will allow for implantation of
the blastocyst
3. Providing the hormonal timing for ovulation
4. Establishing the environment required for maintenance of
pregnancy
5. Providing the hormonal influences for parturition and
lactation