Professional Documents
Culture Documents
Respiratory
Transport O2 from lungs to tissues
Transport CO2 from tissues to lungs
Nutrition
Transport food from gut to tissues (cells)
Excretory
Transport waste from tissues to kidney
(urea, uric acid, water)
Regulatory
Water Content of Tissues
Water exchanged through vessel walls to tissue
Platelets / WBCs
RBCs
More Dense
2. Plasma vs. serum
Plasma is the Serum is the liquid
liquid, cell-free part of blood AFTER
part of blood, that coagulation, therfore
has been treated devoid of clotting
with anti- factors as fibrinogen.
coagulants.
Anticoagulated Clotted
Other components:
Nutrients (e.g. Glucose and amino acids)
Hormones (e.g. Cortisol, thyroxine)
Wastes (e.g. Urea)
Blood gases (e.g. CO2, O2)
Plasma Proteins
General characteristics of plasma proteins
1. They are synthesized in liver except
immunoglobulin.
2. Almost all plasma proteins are
glycoproteins.
3. Each plasma protein has a characteristic
half-life in the circulation.
Plasma proteins
Albumin
Synthesis of albumin:
Liver
half-life: 20 days
- measurement of serum albumin concentration is used to
assays liver function test.
Functions
1. Transport: It can bind and transport many diverse
molecules and serve as low-specificity transport protein,
which include:
a. Metal ions: such as calcium and copper.
b. Free fatty acid: albumin binds to free fatty acid
released by adipose tissue and facilitates their transfer
to other tissue.
c. Bilirubin: this protects from the toxic side effects of
unconjugated bilirubin.
d. Bile acid: albumin carries the bile acids that are
recycle from the intestine to the liver in the hepatic
portal vein.
e. Hormones: such as thyroid hormones and the steroid
hormones.
Maintain osmotic pressure
Colloid osmotic pressure, is a form of osmotic
pressure exerted by proteins in blood plasma that
usually tends to pull water into the circulatory
system.
Because large plasma proteins cannot easily cross
through the capillary walls.
In conditions where plasma proteins are reduced,
e.g. from being lost in the urine (proteinuria) or
from malnutrition,
there will be a reduction in osmotic pressure, leading
to enhanced fluid retention in tissue spaces (edema).
Colloid osmotic pressure
Uploaded By
Hafiz Bilal
Functions of Globulins
Immunoglobulin(Ig)/antibody(Ab)
Classes: IgG, IgM, IgA, IgD, IgE