Professional Documents
Culture Documents
Bagian gizi
Fat
• Dietary fats:
– Polyunsaturated fatty acids
– Monounsaturated fatty acids
– Saturated fatty acids
• Cholesterol
– It is recommended that dietary saturated fat
intake be <7% of energy to reduce CHD risk
Fat
• Dietary fats and cholesterol play a major role
in CHD development
• Saturated fatty acids: contain no double bonds
and generally vary in chain length from 12 to
18 carbons.
• Major sources of saturated fat in diet: dairy,
beef, pork, poultry, and lamb products
Saturated Fatty Acids
• Saturated fatty acids increase LDL-cholesterol
concentrations by decreasing LDL receptor–
mediated catabolism
• This effect is mediated both by decreased LDL
receptor messenger RNA (mRNA) expression and
decreased membrane fluidity
• This latter effect causes less receptor recycling
across the cell membrane.
• It is recommended that dietary saturated fat
intake be <7% of energy to reduce CHD risk
Monounsaturated fatty acids
1Subtractone risk factor for HDL cholesterol ≥ 1.6 mmol/L (60 mg/dL). Diabetes has
been defined as a CHD risk equivalent.
2Defined as CHD in a male first-degree relative aged <55 y or a female first-degree
relative aged <65 y.
1) Male ≥45 y
2) Female ≥55 y
3) Family history of premature CHD2
4) Hypertension
5) Cigarette smoking
6) HDL cholesterol <1.0 mmol/L (40 mg/dL)
National Cholesterol Education Program guidelines on dietary therapy
(Am J Clin Nutr February 2002 vol. 75 no. 2 191-212)
Therapeutic lifestyle
Nutrient Average US diet2 changes
Monounsaturated fat (% of
energy) 13 <20
Polyunsaturated fat (% of
energy) 7 <10
Cholesterol (mg/d) 270 <200
Protein (% of energy) 15 15
Hypertension
• Calcium, potassium, magnesium, phosphorus,
and fiber that would be included in a diet
containing adequate amounts of dairy
products and fruit and vegetables.
• Reduce salt intake (< 5 g/day)
• Maintenance body weight