Professional Documents
Culture Documents
Regeneration (vs repair) of embryonic tissues is the central logic for the field of
REGENERATIVE MEDICINE
The injury response cascade
TROPHIC
The regenerative microenvironment in embryonic tissues is quite different
from the regenerative micro- environment in adult tissues.
Osteogenesis Chondrogenesis Myogenesis Marrow Stroma Tendogenesis
What are Stem Cells?
• Stem cells are the raw material from which all of the body’s
mature, differentiated cells are made. Stem cells give rise to
brain cells, nerve cells, heart cells, pancreatic cells, etc.
∞ They have the potential to replace cell tissue that has been damaged or
destroyed by severe illnesses.
∞ They can replicate themselves over and over for a very long time.
∞ Understanding how stem cells develop into healthy and diseased cells will
assist the search for cures.
Two Vitals of Stem cells
• Stem cells have two important properties:
1. Self renewal
They can go through several cell divisions without
differentiating and in an undifferentiating state.
2. Potency
The capability of differentiating into specialized cell
types.
Self renewal
• Two mechanisms are involved in self renewal
Stem cells can divide in culture to form more of their own kind,
thereby creating a stem cell line.
The research aims to induce these cells to generate healthy tissue needed by
patients.
From where the stem cells can be obtained?
Nucleus removed from an egg The enucleated egg Egg with the somatic cell
Source of cells?
Process of Enucleation
multipotent
oligopotent
Adult Stem Cell Differentiation Properties
Somatic cell nuclear transfer
Use of stem cell therapy for different diseases
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