Professional Documents
Culture Documents
BIOMEDIS
TEAM’S MEMBERS
• Dini Putri A (6130016023)
• Dian Safira D (6130016024)
• Sy. Ali Govinda (6130016025)
• Karina Dwiyanti (6130016026)
• Dinda Hidayatul R (6130016027)
• M Immamudin I I (6130016028)
• Annisa Rakhmawati (6130016029)
• Mirna Wahyuning T (6130016030)
• Ardava Prakosa A (6130016031)
• Afira Febriyani S W (6130016032)
• Siti Kubangsinawati S (6130016033)
SCENARIO
• microRNA
is a family of RNA that does not encode (non-coding RNA) which controls the expression of genes
in cellular signal transduction pathways
• DAP 12
DNAX activating protein of 12KDA
• TGF – β
Regulations that has multifunctional properties that can enhance or inhibit many cell functions,
including disrupt the production of other cytokines and increase collagen deposition. It exists in
multiple subtypes and produced by platelets and macrophages but can be done with many other
cell types.
• Supresion
In genetics, a second mutation that occurs at a different site from the first mutation site and were
able to mask or suppress the expression of phenotypic first mutation; organism seems to be
restored but in reality the double mutant.
DIFFICULT WORDS
• NK cell
A lymphocyte that activated by double-stranded RNA or lymphokines and fight against viral infections
and tumors without apparent antigenic specificity.
• Gene
A functional unit of heredity that occupies a specific place (locus) on the chromosom, is able to reproduce itself
exactly at each cell division, and direct the formation of enzymes or other proteins.
• Tumor
abnormal swelling or enlargement; This is one of the cardinal signs of inflammation.
KEYWORDS
• TGF – β
• microRNA
• NK cell
PROBLEM’S IDENTIFICATION
TGF β
microRNA
DAP 12
Non active NK
cell
LEARNING OBJECTIVE
• To know and understand the signaling pathways that control the activity
of a gene
• To determine the role of microRNA and DAP12 and also associations
between them
• To determine the mechanism of the role of TGF-β against NK cell and its
association with tumor cells
SIGNALLING PATHWAYS THAT
CONTROL THE ACTIVITY OF GENE
MICRORNA FUNCTION
1. Bagaimana hubungan micro rna dengan tgf beta sehingga mereka bisa
menaktifkan tumor tsb? –ilyas
2. Penyebab mutasi dari tgf beta itu apa ya? –nosa
3. Kenapa induksi micro Rna yang menyebabkan protein DAP12 tidak
terekspresi, dan mengakibatkan tidak ada sinyal untuk mobilisasi granulitik? –
munir
4. Mengapa microRNA bisa jadi abnormal? –andik
5. Apakah kalian bisa menjelaskan apakah microrna itu bisa tidak tersekspresi?-
johan