Professional Documents
Culture Documents
Thyroid
hormones
hormones
by
Juniadi Soetowo
Anatomy
and
histology
Posterior View of the Thyroid
gland 4
Thyroid Gland
Iodide trapping
Synthesis
of T3, T4 ● ● ● ●
● ●
● ●
TSH
TSH
Endocytosis
●
●
● ●
● ●
●
●
THYROID HORMONES SYNTHESIS
5
Thyroid hormone
metabolism
(Tetrac)
5’
5 T4
3’ 3
decarboxylation
( thyronamines )
Mechanism
of action
phenol degradation
Actions of Thyroid Hormones
De
Positive regulation of gene
expression by TH
Activated receptors bind to
hormone response elements
which are short specific sequences of
DNA which are located in promoters /
upstream of promoters of hormone –
responsive genes. In most cases,
hormone-receptor complexes bind
DNA in pairs.
Interaction of Thyroid Hormone
Receptors with DNA
Thyroid hormone receptors bind to short, repeated
sequences of DNA called thyroid or T3 response
elements (TREs), a type of hormone response
element.
A TRE is composed of two AGGTCA "half sites"
separated by four nucleotides. The half sites of a
TRE is arranged as direct repeats .
Thyroid
hormone
function
General actions of thyroid
hormones
1- Major effect of T3 & T4 is to enhance general protein synthesis essential
for growth.
for example: T3 enhances transcription of growth hormone (GH)
itself. (anabolic effects of T3)
However, very high T3 levels in blood causes inhibition of protein
synthesis.
DEFISIENSI PIRIDOKSIN
HIPERTIROID + HISTIDIN
DEFISIENSI ASAM
FOLAT
2. PEMBENTUKAN HbA