Medical Project

Recommendations (5)


http://www.chineseowl.idv.tw


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At a recent meeting, members discussed the
increasing incidence of radiation exposure in public spaces.
Radiation exposure increases the risk of cancer among the
general population, as evidenced by medical radiation or radiation-
contaminated environments such as 60Co contaminated buildings,
nuclear power plants, professional use of radiation and radioactive
substances. Given the complexity of radiation exposure in Taiwan,
more thoroughly understanding irradiation safety-related issues is of
priority concern. Despite the use of radiation dosimetery
for acute high dose exposure as an effective means of estimating the
exposure for individuals chronically exposed to ionizing radiation over a
protracted period, dose reconstruction for individuals with previous
long-term and low dose-rate radiation exposure has seldom been
examined, especially when attempting to assess ionization radiation in
order to define low dose rate exposures. (NOTE : Add 2 sentences
that describe characteristics of the problem or statistics that reflect its
severity)
(:)
Exposure to high dosages of ionizing radiation
may increase the incident rate of various cancers. For instance, more
than 200 buildings constructed in Taiwan since 1982 were found to
contain cobalt-60 contaminated steel. The rate at which individuals
receive long-term and low dose-rate radiation exposure ranges from
0.50 to 500.00 uSv/hour, while the background dose rates in most
buildings in Taiwan range from around 0.08 to 0.10uSv. Exposure to a
low dose of ionizing radiation over an extended period of time leads to
chronic illnesses. While possibly damaging DNA
and creating errors in DNA transcription, ionizing radiation may also
directly induce the death of cells or cause gene mutation, subsequently
increasing the incidence rate of cancer. The lack of an effective low
dose rate assessment strategy for radiation-contaminated buildings,
nuclear power plants, professional use of radiation and radioactive
substances) poses a major health threat to the general public.
(:)
Therefore, we recommend developing a low level dose mode
method, capable of accurately predicting the radiation dosage levels in the
surrounding environment of a nuclear power plant that could potentially harm
humans. To do so, radiation dosage distribution and adverse
health impact on neighboring residents can be estimated using the physics dose
mode method with simplified calculations of the mean and standard deviation.
Biological dose models can then be used to relate the location and biological
effects to the controlled exposure factor levels. Next, an optimal combination of
process parameters can be obtained using the estimated risk dosage method.
As anticipated, the proposed low level dose mode method can analyze
the dosage levels of radiation among neighboring residents of a nearby nuclear
power plant. Analysis results of dosage levels inform residents of the health
impact of low level radiation, hopefully leading to a lower dose rate and
occurrence of cancer. Importantly, the low level dose mode method
can enable medical personnel to estimate the radiation dosage distribution
among neighboring residents near a nuclear power plant, providing a valuable
reference for governmental authorities in establishing legislation to protect
inhabitants from unsafe radiation levels. (NOTE : Add 2-4 sentences that
describe more thoroughly how the proposed method contributes to a particular
field or sector)
(:)
In our working group meeting last week, we
discussed our hospitals difficulty in caring for Alzheimers disease
patients. As is well known, silver nanoparticles have an
affinity with a proteins thiol and amino group. Surface plasma
resonance (SPR), a biosensor, can detect proteins because silver
nanoparticles have a coating on SPR, necessitating the ability to use
SPR sensitively and accurately to detect proteins. For instance, a
protein containing amyloid B-derived diffusible ligands (ADDLs) causes
Alzheimers disease. Although local SPR (LSPR) is
more sensitive and accurate than the conventionally adopted SPR,
LSPR has many nanostructures, explaining why sensitivity and
accuracy are of priority concern. Moreover, the conventionally adopted
SPR is more expensive than LSPR. (NOTE : Add 2-4 sentences that
describe characteristics of the problem or statistics that reflect its
severity)
(:)
While the sensitivity of SPR
is 100pM, LSPR must have a higher sensitivity and
accuracy, hopefully below 1pM.
Developing a biosensor without a LSPR would
lead to a more expensive detector. Moreover, the
inability to increase the sensitivity and accuracy of
a biosensor makes it impossible to detect the
biomolecular structure in early stages,
subsequently creating greater problems such as
an increased societal burden in caring for such
patients.
(:)
Therefore, we recommend designing a sensitive and
accurate biosensor that can identify special proteins efficiently, as well as
detect certain diseases in their early stages. For instance, identifying the
protein ADDLs early can be used to diagnose Alzheimers disease in its
early stages so that therapeutic treatment can be administered.
To do so, nanoparticles can be developed in a glass chamber,
followed by the design of a LSPR biosensor. The biomolecular structure
can then be detected using LSPR, enabling us to identify the disease.
As anticipated, the proposed analytical method for detecting
bio molecular structures can detect solution consistency below 1pM with
a high degree of accuracy. Moreover, the proposed LSPR
biosensor can provide a highly sensitive and accurate means of detecting
the bio molecular structure. The ability to identify the disease in its early
stages can lead to earlier treatment and recoery. For instance,
Alzheimers disease can be diagnosed early because LSPR can detect
ADDLs with a high degree of sensitivity, ultimately increasing the survival
rate of patients.
Further details can be found at
http://www.chineseowl.idv.tw