Professional Documents
Culture Documents
Management
ANTIBIOTICS Antifungals Colony stimulating factors: G-CSF
Antivirals
antibiotics at the onset of fever is the accepted standard approach for FN in cancer patient
Disadvantages:
Colonization by hospital-acquired organisms
Antibiotic prophylaxis
CONTROVERSIAL?? Antimicrobial resistance and lack of mortality benefits.
Trimethoprim/sulfamethoxazole is sometimes used to prevent bacterial infectuion in patient expected to be severly neutropenic.
IDSA (infectious disease society of America) AND NCCN (National Comprehensi ve Cancer network)
Monotherapy Imipenem
Meropenem
Tazocin Cefepime
Ceftazidime
Dualtherapy Aminoglycoside plus antipseudomonal penicillin
Duration of therapy:
If organism identified
may change
antibitotics to minimize cost and SEs, but must maintain Broad spectrum coverage to prevent bacteremia. Continue Rx for 7 days, until culture ve, no signs & symptoms.
MONOTHERAPY
ADVANTAGES:
Ease of administration. Less drug interaction. Lower cost & toxicity. less need for drug monitoring.
DISADVATAGES:
No synergism potential .
COMBINATION THERAPY
ADVANTAGES:
Increased bactericidal activity Synergism Broader antibacterial spectrum Limits emergence of resistance
DISADVATAGES:
Drug toxicities Drug interactions Potential cost increase Administration time
Percentage taken from Nada AlRawas thesis Prescribing pattern of antimicrobial agents for chemotherapyinduced FN in patients with hematological malignancies in SQUH
1. Imipenem
intravenous -lactam antibiotic. (subgroup of carbapenems). acts as an antimicrobial through inhibiting cell wall synthesis. broad spectrum of activity against aerobic and anaerobic Gram positive
aeruginosa)
administered alone, and is always co-administered with cilastatin to prevent this inactivation (Imipenem/cilastatin)
SIDE EFFECTS: nausea and vomiting, diarrhea, hypersensitivity
2. Cefipime
4th generation cephalosporin (class of -lactam
antibiotics).
bactericidal and have the same mode of action as other
beta-lactam antibiotics.
true broad-spectrum activity but inactive against
3. Tazocin
An injectable antibacterial combination consisting of antibiotic piperacillin
of its broad spectrum of bactericidal activity patients with systemic and/or local bacterial infections.
Given with aminoglycoside e.g. Gentamycin----- synergistic effect
(strept, e. coli, coagulase-negative staphy, klebsiella pneumonia,)
Cont,
Dosage adjustments are recommended for renal
impairment. Safety and efficacy in children below the age of 12 have not been established. Can be used in pregnancy (only if clearly needed) and elderly but not nursing mothers.
4. Amikacin, Gentamycin
An aminoglycoside (bactericidal antibiotic).
5. Vancomycin
is a glycopeptide antibiotic --- It inhibits cell wall
synthesis
reserved as a drug of "last resort", used only after
Gram-positive bacteria and against multiple drug resistant organisms (MRSA, MRSE ) and antibiotic resistant colitis
ADVERSE EFFECTS: local pain, thrombophlebitis.
Cont,
Intravenous vs oral administration?? Administered via iv slow infusion Note: rapid infusion lead to shock and red man syndrome due to histamine release
Recommended for the these situations:
Suspected serious catheter infections Significant mucositis. Known colonization with organisms resistant
Assessment at 48 hours
Febrile: Check culture & sensitivity data, examine for new focus of infection/ progression of previous infection, change gram negative cover/ add gram positive cover according to results. Afebrile: Consider early discontinuat ion / change to oral antibiotics/ discharge Febrile: Consider other cause of fever, consider occult fungal infection, consider venous access device related
Afebrile:
Assessment at 96 hours
Afebrile: Febrile: Afebrile: Add Amphotericine B 1 mg/kg diluted in 500 cc 5DW over 4 hours Febrile: Consider early discontinuati on / change to oral antibiotics/ discharge
afebrile, no clinical focus identified, no bacteria isolated: Stop after total antibiotics duration of 5-7 days
febrile:
Identify the clinical focus / positive culture & treat appropriately
Lets practice:
66 YEARS OLD WHITE MALE WITH A HISTORY OF CHRONIC LYMPHOCYTIC LEUKEMIA TRANSFORMED TO A DIFFUSE LARGE CELL LYMPHOMA PRESENTED TO THE HOSPITAL WITH FEVER. EIGHT DAYS BEFORE PRESENTATION, HE RECEIVED CYCLOPHOSPHAMIDE, VINCRISTINE AND PREDNISONE CHEMOTHERAPY PLUS RITUXIMAB.
What is the risk stratification? Most commonly prescribed regimen: Persistent fever for 2-4 days or aggravated clinical symptoms for 1-2 days are considered as??
Regarding the initiation, continuation or discontinuation of therapy for the potential failure, you need to consider:
Is adequate antimicrobial therapy being
provided? Is the needed concentration of antimicrobial agent reaching the site of infection? Have resistant pathogen emerged? Is a persistent fever due to underlying disease, abscess formation, iatrogenic complication, a drug reaction, or another process?
Coagulase-negative Escherichia coli staph Enterococcus species Pseudomonas aeruginosa Bacillus species Klebsiella species
Corynebacterium species Proteus mirabilis